TDMS Study 05217-99 Pathology Tables
NTP STATISTICAL ANALYSIS OF PRIMARY TUMORS REPORT: PEIRPT08
LAB: SOUTHERN RESEARCH INST T-BUTYLHYDROQUINONE DATE: 04/11/95
EXPERIMENT: 05217 TEST: 99 TIME: 13:15:05
TEST TYPE: CHRONIC CAGES FROM 0000 TO LAST CAGE PAGE: 1
CONT: N01-ES-85219 ROUTE: DOSED FEED NTP C#: C62157
PATHOLOGIST: J. E. HEATH CAS: 1948-33-0
------------------------------------------------------------------------------------------------------------------------------------
05217/03 -VS- 05217/04 COMPARISON
REASONS FOR REMOVAL: 25019 Moribund Sacrifice
25020 Natural Death
25021 Terminal Sacrifice
REMOVAL DATE RANGE: ALL
TREATMENT GROUPS: INCLUDE 001 UNTREATD CONTROL
INCLUDE 002 UNTREATD CONTROL
INCLUDE 005 RTD UNTRCONTROL
INCLUDE 006 RTD UNTRCONTROL
NTP STATISTICAL ANALYSIS OF PRIMARY TUMORS REPORT: PEIRPT08
LAB: SOUTHERN RESEARCH INST T-BUTYLHYDROQUINONE DATE: 04/11/95
EXPERIMENT: 05217 TEST: 99 TIME: 13:15:05
TEST TYPE: CHRONIC CAGES FROM 0000 TO LAST CAGE
CONT: N01-ES-85219 ROUTE: DOSED FEED NTP C#: C62157
PATHOLOGIST: J. E. HEATH CAS: 1948-33-0
RATS(FISCHER344)
----------------------------
FOR ALL DOSES THE TUMOR RATES IN THE FOLLOWING TISSUES/ORGANS ARE BASED ON NUMBER OF TISSUES EXAMINED.
IN OTHER TISSUES/ORGANS, RATES ARE BASED ON NUMBER OF ANIMALS NECROPSIED.
----------------
Adrenal Cortex
Adrenal Medulla
Bone Marrow
Brain
Clitoral Gland
Clitoral/Preputial Gland
Epididymis
Heart
Islets, Pancreatic
Kidney
Liver
Lung
Nose
Ovary
Pancreas
Parathyroid Gland
Pituitary Gland
Preputial Gland
Prostate
Salivary Glands
Spleen
Testes
Thymus
Thyroid Gland
Urinary Bladder
NTP STATISTICAL ANALYSIS OF PRIMARY TUMORS REPORT: PEIRPT08
LAB: SOUTHERN RESEARCH INST T-BUTYLHYDROQUINONE DATE: 04/11/95
EXPERIMENT: 05217 TEST: 99 TIME: 13:15:05
TEST TYPE: CHRONIC CAGES FROM 0000 TO LAST CAGE
CONT: N01-ES-85219 ROUTE: DOSED FEED NTP C#: C62157
PATHOLOGIST: J. E. HEATH CAS: 1948-33-0
SUMMARY OF STATISTICALLY SIGNIFICANT (P<=.05) RESULTS
IN THE ANALYSIS OF THE STUDY OF T-BUTYLHYDROQUINONE
====================================================================================================
MALE RATS
-------------
ORGAN MORPHOLOGY
------- ------------
Clitoral/Preputial Gland Adenoma
Carcinoma or Adenoma
Islets, Pancreatic Carcinoma or Adenoma
Liver Hepatocellular Adenoma
Mammary Gland Fibroadenoma
Fibroma, Fibroadenoma or Adenoma
Fibroma, Fibroadenoma, Carcinoma, or Adenoma
Pancreas Adenoma
Pituitary Gland: Pars Distalis or Unspecified Site
Adenoma
Carcinoma or Adenoma
Skin Basal or Sq. Cell Carcinoma, Carcinoma, Basosq. Tumor (M or B), Basal
Cell Adenoma, Adenoma, Papilloma, Sq Papilloma, Keratoacanthoma, Trichoepithelioma
Squamous Cell Papilloma, Papilloma, Squamous Cell Carcinoma or Keratoacanthoma
Squamous Cell Papilloma, Papilloma, or Keratoacanthoma
All Organs Benign Tumors
Malignant and Benign Tumors
====================================================================================================
FEMALE RATS
-------------
ORGAN MORPHOLOGY
------- ------------
Adrenal Cortex Adenoma
Clitoral/Preputial Gland Carcinoma
Carcinoma or Adenoma
Mammary Gland Carcinoma
Carcinoma or Adenoma
Fibroadenoma
Fibroma, Fibroadenoma or Adenoma
Fibroma, Fibroadenoma, Carcinoma, or Adenoma
Thyroid Gland: C-Cell Adenoma
Carcinoma or Adenoma
All Organs Leukemia: Lymphocytic, Monocytic, Mononuclear, or Undifferentiated
Benign Tumors
Malignant Tumors
Malignant and Benign Tumors
====================================================================================================
DATE: 04/11/95 EXPERIMENT: 05217 TEST: 99 PAGE 1
STATISTICAL ANALYSIS OF PRIMARY TUMORS IN RATS(FISCHER344) -- T-BUTYLHYDROQUINONE
MALE TERMINAL SACRIFICE AT 123 WEEKS
FEMALE TERMINAL SACRIFICE AT 129 WEEKS
|=================================================================================================================================|
| | | |
| | MALES | FEMALES |
| | | |
|DOSE | UNTREATD RTD UNTR | UNTREATD RTD UNTR |
| | CONTROL CONTROL | CONTROL CONTROL |
|=================================================================================================================================|
| |
|Adrenal Cortex |
| Adenoma |
| |
|---------------------------------------------------------------------------------------------------------------------------------|
|TUMOR RATES | | |
|----------- | | |
|OVERALL (a) | 1/60 (2%) 0/60 (0%) | 4/60 (7%) 0/60 (0%) |
|ADJUSTED (b) | 6.3% 0.0% | 25.9% 0.0% |
|TERMINAL (d) | 0/8 (0%) 0/13 (0%) | 1/10 (10%) 0/18 (0%) |
|FIRST INCIDENCE (DAYS) | 786 --- | 795 --- |
|-----------------------| | |
|STATISTICAL TESTS (f) | | |
|-----------------------| | |
|LIFE TABLE | P=0.403N | P=0.019N* |
|INCIDENTAL TUMOR | P=0.528N | P=0.044N* |
|LOGISTIC REGRESSION | P=0.459N | P=0.022N* |
|COCHRAN-ARMITAGE | | |
|FISHER EXACT | P=0.500N | P=0.059N |
|=================================================================================================================================|
| |
|Adrenal Medulla |
| Pheochromocytoma Benign |
| |
|---------------------------------------------------------------------------------------------------------------------------------|
|TUMOR RATES | | |
|----------- | | |
|OVERALL (a) | 14/60 (23%) 12/59 (20%) | 2/60 (3%) 4/57 (7%) |
|ADJUSTED (b) | 59.8% 55.2% | 16.4% 17.1% |
|TERMINAL (d) | 2/8 (25%) 5/13 (38%) | 1/10 (10%) 2/18 (11%) |
|FIRST INCIDENCE (DAYS) | 667 707 | 856 677 |
|-----------------------| | |
|STATISTICAL TESTS (f) | | |
|-----------------------| | |
|LIFE TABLE | P=0.096N | P=0.592 |
|INCIDENTAL TUMOR | P=0.405N | P=0.468 |
|LOGISTIC REGRESSION | P=0.210N | P=0.500 |
|COCHRAN-ARMITAGE | | |
|FISHER EXACT | P=0.431N | P=0.315 |
|=================================================================================================================================|
DATE: 04/11/95 EXPERIMENT: 05217 TEST: 99 PAGE 2
STATISTICAL ANALYSIS OF PRIMARY TUMORS IN RATS(FISCHER344) -- T-BUTYLHYDROQUINONE
MALE TERMINAL SACRIFICE AT 123 WEEKS
FEMALE TERMINAL SACRIFICE AT 129 WEEKS
|=================================================================================================================================|
| | | |
| | MALES | FEMALES |
| | | |
|DOSE | UNTREATD RTD UNTR | UNTREATD RTD UNTR |
| | CONTROL CONTROL | CONTROL CONTROL |
|=================================================================================================================================|
| |
|Adrenal Medulla |
| Pheochromocytoma Malignant |
| |
|---------------------------------------------------------------------------------------------------------------------------------|
|TUMOR RATES | | |
|----------- | | |
|OVERALL (a) | 1/60 (2%) 2/59 (3%) | 0/60 (0%) 0/57 (0%) |
|ADJUSTED (b) | 3.1% 9.7% | 0.0% 0.0% |
|TERMINAL (d) | 0/8 (0%) 1/13 (8%) | 0/10 (0%) 0/18 (0%) |
|FIRST INCIDENCE (DAYS) | 710 661 | --- --- |
|-----------------------| | |
|STATISTICAL TESTS (f) | | |
|-----------------------| | |
|LIFE TABLE | P=0.577 | (e) (e) |
|INCIDENTAL TUMOR | P=0.516 | (e) (e) |
|LOGISTIC REGRESSION | P=0.513 | (e) (e) |
|COCHRAN-ARMITAGE | | |
|FISHER EXACT | P=0.494 | (e) |
|=================================================================================================================================|
| |
|Adrenal Medulla |
| Pheochromocytoma: Benign, Complex, Malignant, NOS |
| |
|---------------------------------------------------------------------------------------------------------------------------------|
|TUMOR RATES | | |
|----------- | | |
|OVERALL (a) | 14/60 (23%) 15/59 (25%) | 2/60 (3%) 4/57 (7%) |
|ADJUSTED (b) | 59.8% 62.3% | 16.4% 17.1% |
|TERMINAL (d) | 2/8 (25%) 6/13 (46%) | 1/10 (10%) 2/18 (11%) |
|FIRST INCIDENCE (DAYS) | 667 552 | 856 677 |
|-----------------------| | |
|STATISTICAL TESTS (f) | | |
|-----------------------| | |
|LIFE TABLE | P=0.242N | P=0.592 |
|INCIDENTAL TUMOR | P=0.543 | P=0.468 |
|LOGISTIC REGRESSION | P=0.491N | P=0.500 |
|COCHRAN-ARMITAGE | | |
|FISHER EXACT | P=0.479 | P=0.315 |
|=================================================================================================================================|
DATE: 04/11/95 EXPERIMENT: 05217 TEST: 99 PAGE 3
STATISTICAL ANALYSIS OF PRIMARY TUMORS IN RATS(FISCHER344) -- T-BUTYLHYDROQUINONE
MALE TERMINAL SACRIFICE AT 123 WEEKS
FEMALE TERMINAL SACRIFICE AT 129 WEEKS
|=================================================================================================================================|
| | | |
| | MALES | FEMALES |
| | | |
|DOSE | UNTREATD RTD UNTR | UNTREATD RTD UNTR |
| | CONTROL CONTROL | CONTROL CONTROL |
|=================================================================================================================================|
| |
|Brain |
| Oligodendroglioma, Glioma, or Astrocytoma |
| |
|---------------------------------------------------------------------------------------------------------------------------------|
|TUMOR RATES | | |
|----------- | | |
|OVERALL (a) | 2/60 (3%) 0/60 (0%) | 1/60 (2%) 1/60 (2%) |
|ADJUSTED (b) | 5.1% 0.0% | 10.0% 2.2% |
|TERMINAL (d) | 0/8 (0%) 0/13 (0%) | 1/10 (10%) 0/18 (0%) |
|FIRST INCIDENCE (DAYS) | 556 --- | 898 (T) 730 |
|-----------------------| | |
|STATISTICAL TESTS (f) | | |
|-----------------------| | |
|LIFE TABLE | P=0.211N | P=0.666N |
|INCIDENTAL TUMOR | P=0.187N | P=0.693N |
|LOGISTIC REGRESSION | P=0.296N | P=0.721N |
|COCHRAN-ARMITAGE | | |
|FISHER EXACT | P=0.248N | P=0.752N |
|=================================================================================================================================|
| |
|Clitoral/Preputial Gland |
| Adenoma |
| |
|---------------------------------------------------------------------------------------------------------------------------------|
|TUMOR RATES | | |
|----------- | | |
|OVERALL (a) | 5/60 (8%) 1/60 (2%) | 6/58 (10%) 3/59 (5%) |
|ADJUSTED (b) | 31.1% 3.8% | 38.3% 13.4% |
|TERMINAL (d) | 2/8 (25%) 0/13 (0%) | 3/10 (30%) 1/18 (6%) |
|FIRST INCIDENCE (DAYS) | 528 786 | 579 866 |
|-----------------------| | |
|STATISTICAL TESTS (f) | | |
|-----------------------| | |
|LIFE TABLE | P=0.050N* | P=0.065N |
|INCIDENTAL TUMOR | P=0.133N | P=0.131N |
|LOGISTIC REGRESSION | P=0.089N | P=0.100N |
|COCHRAN-ARMITAGE | | |
|FISHER EXACT | P=0.103N | P=0.237N |
|=================================================================================================================================|
DATE: 04/11/95 EXPERIMENT: 05217 TEST: 99 PAGE 4
STATISTICAL ANALYSIS OF PRIMARY TUMORS IN RATS(FISCHER344) -- T-BUTYLHYDROQUINONE
MALE TERMINAL SACRIFICE AT 123 WEEKS
FEMALE TERMINAL SACRIFICE AT 129 WEEKS
|=================================================================================================================================|
| | | |
| | MALES | FEMALES |
| | | |
|DOSE | UNTREATD RTD UNTR | UNTREATD RTD UNTR |
| | CONTROL CONTROL | CONTROL CONTROL |
|=================================================================================================================================|
| |
|Clitoral/Preputial Gland |
| Carcinoma |
| |
|---------------------------------------------------------------------------------------------------------------------------------|
|TUMOR RATES | | |
|----------- | | |
|OVERALL (a) | 2/60 (3%) 1/60 (2%) | 6/58 (10%) 2/59 (3%) |
|ADJUSTED (b) | 3.6% 3.8% | 43.2% 6.2% |
|TERMINAL (d) | 0/8 (0%) 0/13 (0%) | 4/10 (40%) 0/18 (0%) |
|FIRST INCIDENCE (DAYS) | 381 786 | 649 788 |
|-----------------------| | |
|STATISTICAL TESTS (f) | | |
|-----------------------| | |
|LIFE TABLE | P=0.445N | P=0.032N* |
|INCIDENTAL TUMOR | P=0.633N | P=0.054N |
|LOGISTIC REGRESSION | P=0.663N | P=0.053N |
|COCHRAN-ARMITAGE | | |
|FISHER EXACT | P=0.500N | P=0.130N |
|=================================================================================================================================|
| |
|Clitoral/Preputial Gland |
| Carcinoma or Adenoma |
| |
|---------------------------------------------------------------------------------------------------------------------------------|
|TUMOR RATES | | |
|----------- | | |
|OVERALL (a) | 7/60 (12%) 2/60 (3%) | 12/58 (21%) 5/59 (8%) |
|ADJUSTED (b) | 33.6% 7.7% | 74.9% 18.8% |
|TERMINAL (d) | 2/8 (25%) 0/13 (0%) | 7/10 (70%) 1/18 (6%) |
|FIRST INCIDENCE (DAYS) | 381 786 | 579 788 |
|-----------------------| | |
|STATISTICAL TESTS (f) | | |
|-----------------------| | |
|LIFE TABLE | P=0.039N* | P=0.003N** |
|INCIDENTAL TUMOR | P=0.133N | P=0.011N* |
|LOGISTIC REGRESSION | P=0.102N | P=0.008N** |
|COCHRAN-ARMITAGE | | |
|FISHER EXACT | P=0.081N | P=0.053N |
|=================================================================================================================================|
DATE: 04/11/95 EXPERIMENT: 05217 TEST: 99 PAGE 5
STATISTICAL ANALYSIS OF PRIMARY TUMORS IN RATS(FISCHER344) -- T-BUTYLHYDROQUINONE
MALE TERMINAL SACRIFICE AT 123 WEEKS
FEMALE TERMINAL SACRIFICE AT 129 WEEKS
|=================================================================================================================================|
| | | |
| | MALES | FEMALES |
| | | |
|DOSE | UNTREATD RTD UNTR | UNTREATD RTD UNTR |
| | CONTROL CONTROL | CONTROL CONTROL |
|=================================================================================================================================|
| |
|Islets, Pancreatic |
| Adenoma |
| |
|---------------------------------------------------------------------------------------------------------------------------------|
|TUMOR RATES | | |
|----------- | | |
|OVERALL (a) | 5/60 (8%) 2/58 (3%) | 2/60 (3%) 1/60 (2%) |
|ADJUSTED (b) | 32.5% 8.3% | 11.2% 1.9% |
|TERMINAL (d) | 1/8 (13%) 0/13 (0%) | 0/10 (0%) 0/18 (0%) |
|FIRST INCIDENCE (DAYS) | 667 707 | 661 677 |
|-----------------------| | |
|STATISTICAL TESTS (f) | | |
|-----------------------| | |
|LIFE TABLE | P=0.092N | P=0.388N |
|INCIDENTAL TUMOR | P=0.249N | P=0.490N |
|LOGISTIC REGRESSION | P=0.152N | P=0.535N |
|COCHRAN-ARMITAGE | | |
|FISHER EXACT | P=0.234N | P=0.500N |
|=================================================================================================================================|
| |
|Islets, Pancreatic |
| Carcinoma or Adenoma |
| |
|---------------------------------------------------------------------------------------------------------------------------------|
|TUMOR RATES | | |
|----------- | | |
|OVERALL (a) | 6/60 (10%) 2/58 (3%) | 2/60 (3%) 1/60 (2%) |
|ADJUSTED (b) | 42.1% 8.3% | 11.2% 1.9% |
|TERMINAL (d) | 2/8 (25%) 0/13 (0%) | 0/10 (0%) 0/18 (0%) |
|FIRST INCIDENCE (DAYS) | 667 707 | 661 677 |
|-----------------------| | |
|STATISTICAL TESTS (f) | | |
|-----------------------| | |
|LIFE TABLE | P=0.044N* | P=0.388N |
|INCIDENTAL TUMOR | P=0.137N | P=0.490N |
|LOGISTIC REGRESSION | P=0.075N | P=0.535N |
|COCHRAN-ARMITAGE | | |
|FISHER EXACT | P=0.147N | P=0.500N |
|=================================================================================================================================|
DATE: 04/11/95 EXPERIMENT: 05217 TEST: 99 PAGE 6
STATISTICAL ANALYSIS OF PRIMARY TUMORS IN RATS(FISCHER344) -- T-BUTYLHYDROQUINONE
MALE TERMINAL SACRIFICE AT 123 WEEKS
FEMALE TERMINAL SACRIFICE AT 129 WEEKS
|=================================================================================================================================|
| | | |
| | MALES | FEMALES |
| | | |
|DOSE | UNTREATD RTD UNTR | UNTREATD RTD UNTR |
| | CONTROL CONTROL | CONTROL CONTROL |
|=================================================================================================================================|
| |
|Kidney: Renal Tubule |
| Adenoma |
| |
|---------------------------------------------------------------------------------------------------------------------------------|
|TUMOR RATES | | |
|----------- | | |
|OVERALL (a) | 2/60 (3%) 0/60 (0%) | 1/60 (2%) 0/60 (0%) |
|ADJUSTED (b) | 5.6% 0.0% | 10.0% 0.0% |
|TERMINAL (d) | 0/8 (0%) 0/13 (0%) | 1/10 (10%) 0/18 (0%) |
|FIRST INCIDENCE (DAYS) | 694 --- | 898 (T) --- |
|-----------------------| | |
|STATISTICAL TESTS (f) | | |
|-----------------------| | |
|LIFE TABLE | P=0.217N | P=0.383N |
|INCIDENTAL TUMOR | P=0.270N | P=0.383N |
|LOGISTIC REGRESSION | P=0.252N | P=0.383N |
|COCHRAN-ARMITAGE | | |
|FISHER EXACT | P=0.248N | P=0.500N |
|=================================================================================================================================|
| |
|Liver |
| Hepatocellular Adenoma |
| |
|---------------------------------------------------------------------------------------------------------------------------------|
|TUMOR RATES | | |
|----------- | | |
|OVERALL (a) | 4/60 (7%) 0/60 (0%) | 0/60 (0%) 1/60 (2%) |
|ADJUSTED (b) | 25.1% 0.0% | 0.0% 2.0% |
|TERMINAL (d) | 1/8 (13%) 0/13 (0%) | 0/10 (0%) 0/18 (0%) |
|FIRST INCIDENCE (DAYS) | 642 --- | --- 710 |
|-----------------------| | |
|STATISTICAL TESTS (f) | | |
|-----------------------| | |
|LIFE TABLE | P=0.028N* | P=0.546 |
|INCIDENTAL TUMOR | P=0.041N* | P=0.506 |
|LOGISTIC REGRESSION | P=0.045N* | P=0.451 |
|COCHRAN-ARMITAGE | | |
|FISHER EXACT | P=0.059N | P=0.500 |
|=================================================================================================================================|
DATE: 04/11/95 EXPERIMENT: 05217 TEST: 99 PAGE 7
STATISTICAL ANALYSIS OF PRIMARY TUMORS IN RATS(FISCHER344) -- T-BUTYLHYDROQUINONE
MALE TERMINAL SACRIFICE AT 123 WEEKS
FEMALE TERMINAL SACRIFICE AT 129 WEEKS
|=================================================================================================================================|
| | | |
| | MALES | FEMALES |
| | | |
|DOSE | UNTREATD RTD UNTR | UNTREATD RTD UNTR |
| | CONTROL CONTROL | CONTROL CONTROL |
|=================================================================================================================================|
| |
|Lung |
| Alveolar/Bronchiolar Adenoma |
| |
|---------------------------------------------------------------------------------------------------------------------------------|
|TUMOR RATES | | |
|----------- | | |
|OVERALL (a) | 3/60 (5%) 1/60 (2%) | 2/60 (3%) 2/60 (3%) |
|ADJUSTED (b) | 10.2% 7.7% | 14.5% 9.1% |
|TERMINAL (d) | 0/8 (0%) 1/13 (8%) | 1/10 (10%) 0/18 (0%) |
|FIRST INCIDENCE (DAYS) | 618 857 (T) | 802 870 |
|-----------------------| | |
|STATISTICAL TESTS (f) | | |
|-----------------------| | |
|LIFE TABLE | P=0.225N | P=0.477N |
|INCIDENTAL TUMOR | P=0.237N | P=0.634N |
|LOGISTIC REGRESSION | P=0.296N | P=0.534N |
|COCHRAN-ARMITAGE | | |
|FISHER EXACT | P=0.309N | P=0.691N |
|=================================================================================================================================|
| |
|Lung |
| Alveolar/Bronchiolar Carcinoma or Alveolar/Bronchiolar Adenoma |
| |
|---------------------------------------------------------------------------------------------------------------------------------|
|TUMOR RATES | | |
|----------- | | |
|OVERALL (a) | 3/60 (5%) 1/60 (2%) | 2/60 (3%) 3/60 (5%) |
|ADJUSTED (b) | 10.2% 7.7% | 14.5% 11.0% |
|TERMINAL (d) | 0/8 (0%) 1/13 (8%) | 1/10 (10%) 0/18 (0%) |
|FIRST INCIDENCE (DAYS) | 618 857 (T) | 802 711 |
|-----------------------| | |
|STATISTICAL TESTS (f) | | |
|-----------------------| | |
|LIFE TABLE | P=0.225N | P=0.642N |
|INCIDENTAL TUMOR | P=0.237N | P=0.563 |
|LOGISTIC REGRESSION | P=0.296N | P=0.630 |
|COCHRAN-ARMITAGE | | |
|FISHER EXACT | P=0.309N | P=0.500 |
|=================================================================================================================================|
DATE: 04/11/95 EXPERIMENT: 05217 TEST: 99 PAGE 8
STATISTICAL ANALYSIS OF PRIMARY TUMORS IN RATS(FISCHER344) -- T-BUTYLHYDROQUINONE
MALE TERMINAL SACRIFICE AT 123 WEEKS
FEMALE TERMINAL SACRIFICE AT 129 WEEKS
|=================================================================================================================================|
| | | |
| | MALES | FEMALES |
| | | |
|DOSE | UNTREATD RTD UNTR | UNTREATD RTD UNTR |
| | CONTROL CONTROL | CONTROL CONTROL |
|=================================================================================================================================|
| |
|Mammary Gland |
| Adenoma |
| |
|---------------------------------------------------------------------------------------------------------------------------------|
|TUMOR RATES | # # | # # |
|----------- | | |
|OVERALL (a) | 1/60 (2%) 0/60 (0%) | 3/60 (5%) 0/60 (0%) |
|ADJUSTED (b) | 2.3% 0.0% | 9.9% 0.0% |
|TERMINAL (d) | 0/8 (0%) 0/13 (0%) | 0/10 (0%) 0/18 (0%) |
|FIRST INCIDENCE (DAYS) | 668 --- | 613 --- |
|-----------------------| | |
|STATISTICAL TESTS (f) | | |
|-----------------------| | |
|LIFE TABLE | P=0.496N | P=0.078N |
|INCIDENTAL TUMOR | P=0.528N | P=0.134N |
|LOGISTIC REGRESSION | P=0.536N | P=0.160N |
|COCHRAN-ARMITAGE | | |
|FISHER EXACT | P=0.500N | P=0.122N |
|=================================================================================================================================|
| |
|Mammary Gland |
| Carcinoma |
| |
|---------------------------------------------------------------------------------------------------------------------------------|
|TUMOR RATES | # # | # # |
|----------- | | |
|OVERALL (a) | 0/60 (0%) 1/60 (2%) | 8/60 (13%) 1/60 (2%) |
|ADJUSTED (b) | 0.0% 7.7% | 29.3% 5.3% |
|TERMINAL (d) | 0/8 (0%) 1/13 (8%) | 1/10 (10%) 0/18 (0%) |
|FIRST INCIDENCE (DAYS) | --- 857 (T) | 540 892 |
|-----------------------| | |
|STATISTICAL TESTS (f) | | |
|-----------------------| | |
|LIFE TABLE | P=0.597 | P=0.004N** |
|INCIDENTAL TUMOR | P=0.597 | P=0.024N* |
|LOGISTIC REGRESSION | P=0.597 | P=0.015N* |
|COCHRAN-ARMITAGE | | |
|FISHER EXACT | P=0.500 | P=0.016N* |
|=================================================================================================================================|
DATE: 04/11/95 EXPERIMENT: 05217 TEST: 99 PAGE 9
STATISTICAL ANALYSIS OF PRIMARY TUMORS IN RATS(FISCHER344) -- T-BUTYLHYDROQUINONE
MALE TERMINAL SACRIFICE AT 123 WEEKS
FEMALE TERMINAL SACRIFICE AT 129 WEEKS
|=================================================================================================================================|
| | | |
| | MALES | FEMALES |
| | | |
|DOSE | UNTREATD RTD UNTR | UNTREATD RTD UNTR |
| | CONTROL CONTROL | CONTROL CONTROL |
|=================================================================================================================================|
| |
|Mammary Gland |
| Carcinoma or Adenoma |
| |
|---------------------------------------------------------------------------------------------------------------------------------|
|TUMOR RATES | # # | # # |
|----------- | | |
|OVERALL (a) | 1/60 (2%) 1/60 (2%) | 10/60 (17%) 1/60 (2%) |
|ADJUSTED (b) | 2.3% 7.7% | 34.9% 5.3% |
|TERMINAL (d) | 0/8 (0%) 1/13 (8%) | 1/10 (10%) 0/18 (0%) |
|FIRST INCIDENCE (DAYS) | 668 857 (T) | 540 892 |
|-----------------------| | |
|STATISTICAL TESTS (f) | | |
|-----------------------| | |
|LIFE TABLE | P=0.705N | P=0.001N** |
|INCIDENTAL TUMOR | P=0.725N | P=0.008N** |
|LOGISTIC REGRESSION | P=0.739N | P=0.005N** |
|COCHRAN-ARMITAGE | | |
|FISHER EXACT | P=0.752N | P=0.004N** |
|=================================================================================================================================|
| |
|Mammary Gland |
| Fibroadenoma |
| |
|---------------------------------------------------------------------------------------------------------------------------------|
|TUMOR RATES | # # | # # |
|----------- | | |
|OVERALL (a) | 10/60 (17%) 4/60 (7%) | 43/60 (72%) 30/60 (50%) |
|ADJUSTED (b) | 72.0% 17.8% | 100.0% 86.8% |
|TERMINAL (d) | 5/8 (63%) 1/13 (8%) | 10/10 (100%) 14/18 (78%) |
|FIRST INCIDENCE (DAYS) | 381 745 | 418 688 |
|-----------------------| | |
|STATISTICAL TESTS (f) | | |
|-----------------------| | |
|LIFE TABLE | P=0.010N** | P<0.001N** |
|INCIDENTAL TUMOR | P=0.059N | P<0.001N** |
|LOGISTIC REGRESSION | P=0.019N* | P<0.001N** |
|COCHRAN-ARMITAGE | | |
|FISHER EXACT | P=0.077N | P=0.012N* |
|=================================================================================================================================|
DATE: 04/11/95 EXPERIMENT: 05217 TEST: 99 PAGE 10
STATISTICAL ANALYSIS OF PRIMARY TUMORS IN RATS(FISCHER344) -- T-BUTYLHYDROQUINONE
MALE TERMINAL SACRIFICE AT 123 WEEKS
FEMALE TERMINAL SACRIFICE AT 129 WEEKS
|=================================================================================================================================|
| | | |
| | MALES | FEMALES |
| | | |
|DOSE | UNTREATD RTD UNTR | UNTREATD RTD UNTR |
| | CONTROL CONTROL | CONTROL CONTROL |
|=================================================================================================================================|
| |
|Mammary Gland |
| Fibroma, Fibroadenoma or Adenoma |
| |
|---------------------------------------------------------------------------------------------------------------------------------|
|TUMOR RATES | # # | # # |
|----------- | | |
|OVERALL (a) | 11/60 (18%) 4/60 (7%) | 45/60 (75%) 30/60 (50%) |
|ADJUSTED (b) | 72.6% 17.8% | 100.0% 86.8% |
|TERMINAL (d) | 5/8 (63%) 1/13 (8%) | 10/10 (100%) 14/18 (78%) |
|FIRST INCIDENCE (DAYS) | 381 745 | 418 688 |
|-----------------------| | |
|STATISTICAL TESTS (f) | | |
|-----------------------| | |
|LIFE TABLE | P=0.006N** | P<0.001N** |
|INCIDENTAL TUMOR | P=0.038N* | P<0.001N** |
|LOGISTIC REGRESSION | P=0.013N* | P<0.001N** |
|COCHRAN-ARMITAGE | | |
|FISHER EXACT | P=0.048N* | P=0.004N** |
|=================================================================================================================================|
| |
|Mammary Gland |
| Fibroma, Fibroadenoma, Carcinoma, or Adenoma |
| |
|---------------------------------------------------------------------------------------------------------------------------------|
|TUMOR RATES | # # | # # |
|----------- | | |
|OVERALL (a) | 11/60 (18%) 5/60 (8%) | 48/60 (80%) 31/60 (52%) |
|ADJUSTED (b) | 72.6% 24.7% | 100.0% 87.5% |
|TERMINAL (d) | 5/8 (63%) 2/13 (15%) | 10/10 (100%) 14/18 (78%) |
|FIRST INCIDENCE (DAYS) | 381 745 | 418 688 |
|-----------------------| | |
|STATISTICAL TESTS (f) | | |
|-----------------------| | |
|LIFE TABLE | P=0.011N* | P<0.001N** |
|INCIDENTAL TUMOR | P=0.063N | P<0.001N** |
|LOGISTIC REGRESSION | P=0.024N* | P<0.001N** |
|COCHRAN-ARMITAGE | | |
|FISHER EXACT | P=0.089N | P<0.001N** |
|=================================================================================================================================|
DATE: 04/11/95 EXPERIMENT: 05217 TEST: 99 PAGE 11
STATISTICAL ANALYSIS OF PRIMARY TUMORS IN RATS(FISCHER344) -- T-BUTYLHYDROQUINONE
MALE TERMINAL SACRIFICE AT 123 WEEKS
FEMALE TERMINAL SACRIFICE AT 129 WEEKS
|=================================================================================================================================|
| | | |
| | MALES | FEMALES |
| | | |
|DOSE | UNTREATD RTD UNTR | UNTREATD RTD UNTR |
| | CONTROL CONTROL | CONTROL CONTROL |
|=================================================================================================================================|
| |
|Oral Cavity (Oral Mucosa, Tongue, Pharynx, Tooth, Gingiva) |
| Squamous Cell Carcinoma |
| |
|---------------------------------------------------------------------------------------------------------------------------------|
|TUMOR RATES | # # | # # |
|----------- | | |
|OVERALL (a) | 2/60 (3%) 1/60 (2%) | 0/60 (0%) 0/60 (0%) |
|ADJUSTED (b) | 6.9% 4.3% | 0.0% 0.0% |
|TERMINAL (d) | 0/8 (0%) 0/13 (0%) | 0/10 (0%) 0/18 (0%) |
|FIRST INCIDENCE (DAYS) | 489 796 | --- --- |
|-----------------------| | |
|STATISTICAL TESTS (f) | | |
|-----------------------| | |
|LIFE TABLE | P=0.383N | (e) (e) |
|INCIDENTAL TUMOR | P=0.717N | (e) (e) |
|LOGISTIC REGRESSION | P=0.541N | (e) (e) |
|COCHRAN-ARMITAGE | | |
|FISHER EXACT | P=0.500N | (e) |
|=================================================================================================================================|
| |
|Oral Cavity (Oral Mucosa, Tongue, Pharynx, Tooth, Gingiva) |
| Squamous Cell Carcinoma, Papilloma Squamous, or Papilloma |
| |
|---------------------------------------------------------------------------------------------------------------------------------|
|TUMOR RATES | # # | # # |
|----------- | | |
|OVERALL (a) | 2/60 (3%) 1/60 (2%) | 1/60 (2%) 0/60 (0%) |
|ADJUSTED (b) | 6.9% 4.3% | 10.0% 0.0% |
|TERMINAL (d) | 0/8 (0%) 0/13 (0%) | 1/10 (10%) 0/18 (0%) |
|FIRST INCIDENCE (DAYS) | 489 796 | 898 (T) --- |
|-----------------------| | |
|STATISTICAL TESTS (f) | | |
|-----------------------| | |
|LIFE TABLE | P=0.383N | P=0.383N |
|INCIDENTAL TUMOR | P=0.717N | P=0.383N |
|LOGISTIC REGRESSION | P=0.541N | P=0.383N |
|COCHRAN-ARMITAGE | | |
|FISHER EXACT | P=0.500N | P=0.500N |
|=================================================================================================================================|
DATE: 04/11/95 EXPERIMENT: 05217 TEST: 99 PAGE 12
STATISTICAL ANALYSIS OF PRIMARY TUMORS IN RATS(FISCHER344) -- T-BUTYLHYDROQUINONE
MALE TERMINAL SACRIFICE AT 123 WEEKS
FEMALE TERMINAL SACRIFICE AT 129 WEEKS
|=================================================================================================================================|
| | | |
| | MALES | FEMALES |
| | | |
|DOSE | UNTREATD RTD UNTR | UNTREATD RTD UNTR |
| | CONTROL CONTROL | CONTROL CONTROL |
|=================================================================================================================================|
| |
|Ovary |
| Granulosa Cell Tumor Benign |
| |
|---------------------------------------------------------------------------------------------------------------------------------|
|TUMOR RATES | | |
|----------- | | |
|OVERALL (a) | | 1/60 (2%) 2/60 (3%) |
|ADJUSTED (b) | | 7.7% 7.0% |
|TERMINAL (d) | | 0/10 (0%) 0/18 (0%) |
|FIRST INCIDENCE (DAYS) | | 879 837 |
|-----------------------| | |
|STATISTICAL TESTS (f) | | |
|-----------------------| | |
|LIFE TABLE | | P=0.688 |
|INCIDENTAL TUMOR | | P=0.510 |
|LOGISTIC REGRESSION | | P=0.641 |
|COCHRAN-ARMITAGE | | |
|FISHER EXACT | | P=0.500 |
|=================================================================================================================================|
| |
|Ovary |
| Granulosa Cell Tumor: Benign, Malignant, NOS |
| |
|---------------------------------------------------------------------------------------------------------------------------------|
|TUMOR RATES | | |
|----------- | | |
|OVERALL (a) | | 1/60 (2%) 3/60 (5%) |
|ADJUSTED (b) | | 7.7% 9.7% |
|TERMINAL (d) | | 0/10 (0%) 0/18 (0%) |
|FIRST INCIDENCE (DAYS) | | 879 820 |
|-----------------------| | |
|STATISTICAL TESTS (f) | | |
|-----------------------| | |
|LIFE TABLE | | P=0.529 |
|INCIDENTAL TUMOR | | P=0.315 |
|LOGISTIC REGRESSION | | P=0.438 |
|COCHRAN-ARMITAGE | | |
|FISHER EXACT | | P=0.309 |
|=================================================================================================================================|
DATE: 04/11/95 EXPERIMENT: 05217 TEST: 99 PAGE 13
STATISTICAL ANALYSIS OF PRIMARY TUMORS IN RATS(FISCHER344) -- T-BUTYLHYDROQUINONE
MALE TERMINAL SACRIFICE AT 123 WEEKS
FEMALE TERMINAL SACRIFICE AT 129 WEEKS
|=================================================================================================================================|
| | | |
| | MALES | FEMALES |
| | | |
|DOSE | UNTREATD RTD UNTR | UNTREATD RTD UNTR |
| | CONTROL CONTROL | CONTROL CONTROL |
|=================================================================================================================================|
| |
|Pancreas |
| Adenoma |
| |
|---------------------------------------------------------------------------------------------------------------------------------|
|TUMOR RATES | | |
|----------- | | |
|OVERALL (a) | 3/60 (5%) 0/58 (0%) | 0/60 (0%) 0/60 (0%) |
|ADJUSTED (b) | 37.5% 0.0% | 0.0% 0.0% |
|TERMINAL (d) | 3/8 (38%) 0/13 (0%) | 0/10 (0%) 0/18 (0%) |
|FIRST INCIDENCE (DAYS) | 857 (T) --- | --- --- |
|-----------------------| | |
|STATISTICAL TESTS (f) | | |
|-----------------------| | |
|LIFE TABLE | P=0.044N* | (e) (e) |
|INCIDENTAL TUMOR | P=0.044N* | (e) (e) |
|LOGISTIC REGRESSION | P=0.044N* | (e) (e) |
|COCHRAN-ARMITAGE | | |
|FISHER EXACT | P=0.128N | (e) |
|=================================================================================================================================|
| |
|Parathyroid Gland |
| Adenoma |
| |
|---------------------------------------------------------------------------------------------------------------------------------|
|TUMOR RATES | | |
|----------- | | |
|OVERALL (a) | 0/55 (0%) 0/56 (0%) | 2/52 (4%) 0/55 (0%) |
|ADJUSTED (b) | 0.0% 0.0% | 7.7% 0.0% |
|TERMINAL (d) | 0/8 (0%) 0/12 (0%) | 0/8 (0%) 0/18 (0%) |
|FIRST INCIDENCE (DAYS) | --- --- | 785 --- |
|-----------------------| | |
|STATISTICAL TESTS (f) | | |
|-----------------------| | |
|LIFE TABLE | (e) (e) | P=0.153N |
|INCIDENTAL TUMOR | (e) (e) | P=0.209N |
|LOGISTIC REGRESSION | (e) (e) | P=0.189N |
|COCHRAN-ARMITAGE | | |
|FISHER EXACT | (e) | P=0.234N |
|=================================================================================================================================|
DATE: 04/11/95 EXPERIMENT: 05217 TEST: 99 PAGE 14
STATISTICAL ANALYSIS OF PRIMARY TUMORS IN RATS(FISCHER344) -- T-BUTYLHYDROQUINONE
MALE TERMINAL SACRIFICE AT 123 WEEKS
FEMALE TERMINAL SACRIFICE AT 129 WEEKS
|=================================================================================================================================|
| | | |
| | MALES | FEMALES |
| | | |
|DOSE | UNTREATD RTD UNTR | UNTREATD RTD UNTR |
| | CONTROL CONTROL | CONTROL CONTROL |
|=================================================================================================================================|
| |
|Pituitary Gland: Pars Distalis or Unspecified Site |
| Adenoma |
| |
|---------------------------------------------------------------------------------------------------------------------------------|
|TUMOR RATES | | |
|----------- | | |
|OVERALL (a) | 19/60 (32%) 13/57 (23%) | 26/60 (43%) 30/59 (51%) |
|ADJUSTED (b) | 63.8% 43.6% | 80.9% 81.1% |
|TERMINAL (d) | 2/8 (25%) 2/13 (15%) | 5/10 (50%) 11/17 (65%) |
|FIRST INCIDENCE (DAYS) | 528 569 | 540 638 |
|-----------------------| | |
|STATISTICAL TESTS (f) | | |
|-----------------------| | |
|LIFE TABLE | P=0.038N* | P=0.120N |
|INCIDENTAL TUMOR | P=0.191N | P=0.546 |
|LOGISTIC REGRESSION | P=0.159N | P=0.484N |
|COCHRAN-ARMITAGE | | |
|FISHER EXACT | P=0.193N | P=0.262 |
|=================================================================================================================================|
| |
|Pituitary Gland: Pars Distalis or Unspecified Site |
| Carcinoma |
| |
|---------------------------------------------------------------------------------------------------------------------------------|
|TUMOR RATES | | |
|----------- | | |
|OVERALL (a) | 0/60 (0%) 0/57 (0%) | 2/60 (3%) 0/59 (0%) |
|ADJUSTED (b) | 0.0% 0.0% | 5.0% 0.0% |
|TERMINAL (d) | 0/8 (0%) 0/13 (0%) | 0/10 (0%) 0/17 (0%) |
|FIRST INCIDENCE (DAYS) | --- --- | 540 --- |
|-----------------------| | |
|STATISTICAL TESTS (f) | | |
|-----------------------| | |
|LIFE TABLE | (e) (e) | P=0.195N |
|INCIDENTAL TUMOR | (e) (e) | P=0.413N |
|LOGISTIC REGRESSION | (e) (e) | P=0.337N |
|COCHRAN-ARMITAGE | | |
|FISHER EXACT | (e) | P=0.252N |
|=================================================================================================================================|
DATE: 04/11/95 EXPERIMENT: 05217 TEST: 99 PAGE 15
STATISTICAL ANALYSIS OF PRIMARY TUMORS IN RATS(FISCHER344) -- T-BUTYLHYDROQUINONE
MALE TERMINAL SACRIFICE AT 123 WEEKS
FEMALE TERMINAL SACRIFICE AT 129 WEEKS
|=================================================================================================================================|
| | | |
| | MALES | FEMALES |
| | | |
|DOSE | UNTREATD RTD UNTR | UNTREATD RTD UNTR |
| | CONTROL CONTROL | CONTROL CONTROL |
|=================================================================================================================================|
| |
|Pituitary Gland: Pars Distalis or Unspecified Site |
| Carcinoma or Adenoma |
| |
|---------------------------------------------------------------------------------------------------------------------------------|
|TUMOR RATES | | |
|----------- | | |
|OVERALL (a) | 19/60 (32%) 13/57 (23%) | 28/60 (47%) 30/59 (51%) |
|ADJUSTED (b) | 63.8% 43.6% | 81.9% 81.1% |
|TERMINAL (d) | 2/8 (25%) 2/13 (15%) | 5/10 (50%) 11/17 (65%) |
|FIRST INCIDENCE (DAYS) | 528 569 | 540 638 |
|-----------------------| | |
|STATISTICAL TESTS (f) | | |
|-----------------------| | |
|LIFE TABLE | P=0.038N* | P=0.070N |
|INCIDENTAL TUMOR | P=0.191N | P=0.510N |
|LOGISTIC REGRESSION | P=0.159N | P=0.364N |
|COCHRAN-ARMITAGE | | |
|FISHER EXACT | P=0.193N | P=0.393 |
|=================================================================================================================================|
| |
|Prostate |
| Adenoma |
| |
|---------------------------------------------------------------------------------------------------------------------------------|
|TUMOR RATES | | |
|----------- | | |
|OVERALL (a) | 2/60 (3%) 0/60 (0%) | |
|ADJUSTED (b) | 25.0% 0.0% | |
|TERMINAL (d) | 2/8 (25%) 0/13 (0%) | |
|FIRST INCIDENCE (DAYS) | 857 (T) --- | |
|-----------------------| | |
|STATISTICAL TESTS (f) | | |
|-----------------------| | |
|LIFE TABLE | P=0.135N | |
|INCIDENTAL TUMOR | P=0.135N | |
|LOGISTIC REGRESSION | P=0.135N | |
|COCHRAN-ARMITAGE | | |
|FISHER EXACT | P=0.248N | |
|=================================================================================================================================|
DATE: 04/11/95 EXPERIMENT: 05217 TEST: 99 PAGE 16
STATISTICAL ANALYSIS OF PRIMARY TUMORS IN RATS(FISCHER344) -- T-BUTYLHYDROQUINONE
MALE TERMINAL SACRIFICE AT 123 WEEKS
FEMALE TERMINAL SACRIFICE AT 129 WEEKS
|=================================================================================================================================|
| | | |
| | MALES | FEMALES |
| | | |
|DOSE | UNTREATD RTD UNTR | UNTREATD RTD UNTR |
| | CONTROL CONTROL | CONTROL CONTROL |
|=================================================================================================================================|
| |
|Skin |
| Basal Cell Carcinoma, Basal Cell Adenoma, Basosquamous Tumor (benign, |
| malignant or NOS), or Trichoepithelioma |
| |
|---------------------------------------------------------------------------------------------------------------------------------|
|TUMOR RATES | # # | # # |
|----------- | | |
|OVERALL (a) | 3/60 (5%) 1/60 (2%) | 1/60 (2%) 2/60 (3%) |
|ADJUSTED (b) | 16.5% 7.7% | 2.2% 7.5% |
|TERMINAL (d) | 0/8 (0%) 1/13 (8%) | 0/10 (0%) 0/18 (0%) |
|FIRST INCIDENCE (DAYS) | 759 857 (T) | 640 777 |
|-----------------------| | |
|STATISTICAL TESTS (f) | | |
|-----------------------| | |
|LIFE TABLE | P=0.168N | P=0.639 |
|INCIDENTAL TUMOR | P=0.300N | P=0.489 |
|LOGISTIC REGRESSION | P=0.223N | P=0.507 |
|COCHRAN-ARMITAGE | | |
|FISHER EXACT | P=0.309N | P=0.500 |
|=================================================================================================================================|
| |
|Skin |
| Basal or Sq. Cell Carcinoma, Carcinoma, Basosq. Tumor (M or B), Basal |
| Cell Adenoma, Adenoma, Papilloma, Sq Papilloma, Keratoacanthoma, Trichoepithelioma |
| |
|---------------------------------------------------------------------------------------------------------------------------------|
|TUMOR RATES | # # | # # |
|----------- | | |
|OVERALL (a) | 8/60 (13%) 2/60 (3%) | 1/60 (2%) 2/60 (3%) |
|ADJUSTED (b) | 50.3% 15.4% | 2.2% 7.5% |
|TERMINAL (d) | 3/8 (38%) 2/13 (15%) | 0/10 (0%) 0/18 (0%) |
|FIRST INCIDENCE (DAYS) | 667 857 (T) | 640 777 |
|-----------------------| | |
|STATISTICAL TESTS (f) | | |
|-----------------------| | |
|LIFE TABLE | P=0.009N** | P=0.639 |
|INCIDENTAL TUMOR | P=0.022N* | P=0.489 |
|LOGISTIC REGRESSION | P=0.016N* | P=0.507 |
|COCHRAN-ARMITAGE | | |
|FISHER EXACT | P=0.047N* | P=0.500 |
|=================================================================================================================================|
DATE: 04/11/95 EXPERIMENT: 05217 TEST: 99 PAGE 17
STATISTICAL ANALYSIS OF PRIMARY TUMORS IN RATS(FISCHER344) -- T-BUTYLHYDROQUINONE
MALE TERMINAL SACRIFICE AT 123 WEEKS
FEMALE TERMINAL SACRIFICE AT 129 WEEKS
|=================================================================================================================================|
| | | |
| | MALES | FEMALES |
| | | |
|DOSE | UNTREATD RTD UNTR | UNTREATD RTD UNTR |
| | CONTROL CONTROL | CONTROL CONTROL |
|=================================================================================================================================|
| |
|Skin |
| Fibroma |
| |
|---------------------------------------------------------------------------------------------------------------------------------|
|TUMOR RATES | # # | # # |
|----------- | | |
|OVERALL (a) | 4/60 (7%) 6/60 (10%) | 3/60 (5%) 1/60 (2%) |
|ADJUSTED (b) | 30.0% 32.3% | 13.8% 3.7% |
|TERMINAL (d) | 1/8 (13%) 3/13 (23%) | 1/10 (10%) 0/18 (0%) |
|FIRST INCIDENCE (DAYS) | 761 730 | 540 856 |
|-----------------------| | |
|STATISTICAL TESTS (f) | | |
|-----------------------| | |
|LIFE TABLE | P=0.588N | P=0.186N |
|INCIDENTAL TUMOR | P=0.437 | P=0.378N |
|LOGISTIC REGRESSION | P=0.594 | P=0.326N |
|COCHRAN-ARMITAGE | | |
|FISHER EXACT | P=0.372 | P=0.309N |
|=================================================================================================================================|
| |
|Skin |
| Fibroma, Fibrosarcoma, Sarcoma, Myxoma, Myxosarcoma, or Fibrous Histiocytoma |
| |
|---------------------------------------------------------------------------------------------------------------------------------|
|TUMOR RATES | # # | # # |
|----------- | | |
|OVERALL (a) | 5/60 (8%) 6/60 (10%) | 4/60 (7%) 1/60 (2%) |
|ADJUSTED (b) | 40.0% 32.3% | 19.9% 3.7% |
|TERMINAL (d) | 2/8 (25%) 3/13 (23%) | 1/10 (10%) 0/18 (0%) |
|FIRST INCIDENCE (DAYS) | 761 730 | 540 856 |
|-----------------------| | |
|STATISTICAL TESTS (f) | | |
|-----------------------| | |
|LIFE TABLE | P=0.425N | P=0.078N |
|INCIDENTAL TUMOR | P=0.599 | P=0.222N |
|LOGISTIC REGRESSION | P=0.507N | P=0.167N |
|COCHRAN-ARMITAGE | | |
|FISHER EXACT | P=0.500 | P=0.182N |
|=================================================================================================================================|
DATE: 04/11/95 EXPERIMENT: 05217 TEST: 99 PAGE 18
STATISTICAL ANALYSIS OF PRIMARY TUMORS IN RATS(FISCHER344) -- T-BUTYLHYDROQUINONE
MALE TERMINAL SACRIFICE AT 123 WEEKS
FEMALE TERMINAL SACRIFICE AT 129 WEEKS
|=================================================================================================================================|
| | | |
| | MALES | FEMALES |
| | | |
|DOSE | UNTREATD RTD UNTR | UNTREATD RTD UNTR |
| | CONTROL CONTROL | CONTROL CONTROL |
|=================================================================================================================================|
| |
|Skin |
| Keratoacanthoma |
| |
|---------------------------------------------------------------------------------------------------------------------------------|
|TUMOR RATES | # # | # # |
|----------- | | |
|OVERALL (a) | 4/60 (7%) 1/60 (2%) | 0/60 (0%) 0/60 (0%) |
|ADJUSTED (b) | 28.6% 7.7% | 0.0% 0.0% |
|TERMINAL (d) | 2/8 (25%) 1/13 (8%) | 0/10 (0%) 0/18 (0%) |
|FIRST INCIDENCE (DAYS) | 667 857 (T) | --- --- |
|-----------------------| | |
|STATISTICAL TESTS (f) | | |
|-----------------------| | |
|LIFE TABLE | P=0.096N | (e) (e) |
|INCIDENTAL TUMOR | P=0.113N | (e) (e) |
|LOGISTIC REGRESSION | P=0.122N | (e) (e) |
|COCHRAN-ARMITAGE | | |
|FISHER EXACT | P=0.182N | (e) |
|=================================================================================================================================|
| |
|Skin |
| Squamous Cell Papilloma |
| |
|---------------------------------------------------------------------------------------------------------------------------------|
|TUMOR RATES | # # | # # |
|----------- | | |
|OVERALL (a) | 2/60 (3%) 0/60 (0%) | 0/60 (0%) 0/60 (0%) |
|ADJUSTED (b) | 19.2% 0.0% | 0.0% 0.0% |
|TERMINAL (d) | 1/8 (13%) 0/13 (0%) | 0/10 (0%) 0/18 (0%) |
|FIRST INCIDENCE (DAYS) | 795 --- | --- --- |
|-----------------------| | |
|STATISTICAL TESTS (f) | | |
|-----------------------| | |
|LIFE TABLE | P=0.134N | (e) (e) |
|INCIDENTAL TUMOR | P=0.201N | (e) (e) |
|LOGISTIC REGRESSION | P=0.149N | (e) (e) |
|COCHRAN-ARMITAGE | | |
|FISHER EXACT | P=0.248N | (e) |
|=================================================================================================================================|
DATE: 04/11/95 EXPERIMENT: 05217 TEST: 99 PAGE 19
STATISTICAL ANALYSIS OF PRIMARY TUMORS IN RATS(FISCHER344) -- T-BUTYLHYDROQUINONE
MALE TERMINAL SACRIFICE AT 123 WEEKS
FEMALE TERMINAL SACRIFICE AT 129 WEEKS
|=================================================================================================================================|
| | | |
| | MALES | FEMALES |
| | | |
|DOSE | UNTREATD RTD UNTR | UNTREATD RTD UNTR |
| | CONTROL CONTROL | CONTROL CONTROL |
|=================================================================================================================================|
| |
|Skin |
| Squamous Cell Papilloma, Papilloma, Squamous Cell Carcinoma or Keratoacanthoma |
| |
|---------------------------------------------------------------------------------------------------------------------------------|
|TUMOR RATES | # # | # # |
|----------- | | |
|OVERALL (a) | 6/60 (10%) 1/60 (2%) | 0/60 (0%) 0/60 (0%) |
|ADJUSTED (b) | 45.1% 7.7% | 0.0% 0.0% |
|TERMINAL (d) | 3/8 (38%) 1/13 (8%) | 0/10 (0%) 0/18 (0%) |
|FIRST INCIDENCE (DAYS) | 667 857 (T) | --- --- |
|-----------------------| | |
|STATISTICAL TESTS (f) | | |
|-----------------------| | |
|LIFE TABLE | P=0.016N* | (e) (e) |
|INCIDENTAL TUMOR | P=0.028N* | (e) (e) |
|LOGISTIC REGRESSION | P=0.025N* | (e) (e) |
|COCHRAN-ARMITAGE | | |
|FISHER EXACT | P=0.057N | (e) |
|=================================================================================================================================|
| |
|Skin |
| Squamous Cell Papilloma, Papilloma, or Keratoacanthoma |
| |
|---------------------------------------------------------------------------------------------------------------------------------|
|TUMOR RATES | # # | # # |
|----------- | | |
|OVERALL (a) | 6/60 (10%) 1/60 (2%) | 0/60 (0%) 0/60 (0%) |
|ADJUSTED (b) | 45.1% 7.7% | 0.0% 0.0% |
|TERMINAL (d) | 3/8 (38%) 1/13 (8%) | 0/10 (0%) 0/18 (0%) |
|FIRST INCIDENCE (DAYS) | 667 857 (T) | --- --- |
|-----------------------| | |
|STATISTICAL TESTS (f) | | |
|-----------------------| | |
|LIFE TABLE | P=0.016N* | (e) (e) |
|INCIDENTAL TUMOR | P=0.028N* | (e) (e) |
|LOGISTIC REGRESSION | P=0.025N* | (e) (e) |
|COCHRAN-ARMITAGE | | |
|FISHER EXACT | P=0.057N | (e) |
|=================================================================================================================================|
DATE: 04/11/95 EXPERIMENT: 05217 TEST: 99 PAGE 20
STATISTICAL ANALYSIS OF PRIMARY TUMORS IN RATS(FISCHER344) -- T-BUTYLHYDROQUINONE
MALE TERMINAL SACRIFICE AT 123 WEEKS
FEMALE TERMINAL SACRIFICE AT 129 WEEKS
|=================================================================================================================================|
| | | |
| | MALES | FEMALES |
| | | |
|DOSE | UNTREATD RTD UNTR | UNTREATD RTD UNTR |
| | CONTROL CONTROL | CONTROL CONTROL |
|=================================================================================================================================|
| |
|Skin |
| Trichoepithelioma |
| |
|---------------------------------------------------------------------------------------------------------------------------------|
|TUMOR RATES | # # | # # |
|----------- | | |
|OVERALL (a) | 2/60 (3%) 0/60 (0%) | 0/60 (0%) 1/60 (2%) |
|ADJUSTED (b) | 12.1% 0.0% | 0.0% 2.4% |
|TERMINAL (d) | 0/8 (0%) 0/13 (0%) | 0/10 (0%) 0/18 (0%) |
|FIRST INCIDENCE (DAYS) | 759 --- | --- 777 |
|-----------------------| | |
|STATISTICAL TESTS (f) | | |
|-----------------------| | |
|LIFE TABLE | P=0.145N | P=0.581 |
|INCIDENTAL TUMOR | P=0.270N | P=0.506 |
|LOGISTIC REGRESSION | P=0.199N | P=0.511 |
|COCHRAN-ARMITAGE | | |
|FISHER EXACT | P=0.248N | P=0.500 |
|=================================================================================================================================|
| |
|Spleen |
| Fibroma |
| |
|---------------------------------------------------------------------------------------------------------------------------------|
|TUMOR RATES | | |
|----------- | | |
|OVERALL (a) | 2/60 (3%) 0/60 (0%) | 0/60 (0%) 0/60 (0%) |
|ADJUSTED (b) | 19.2% 0.0% | 0.0% 0.0% |
|TERMINAL (d) | 1/8 (13%) 0/13 (0%) | 0/10 (0%) 0/18 (0%) |
|FIRST INCIDENCE (DAYS) | 795 --- | --- --- |
|-----------------------| | |
|STATISTICAL TESTS (f) | | |
|-----------------------| | |
|LIFE TABLE | P=0.134N | (e) (e) |
|INCIDENTAL TUMOR | P=0.201N | (e) (e) |
|LOGISTIC REGRESSION | P=0.149N | (e) (e) |
|COCHRAN-ARMITAGE | | |
|FISHER EXACT | P=0.248N | (e) |
|=================================================================================================================================|
DATE: 04/11/95 EXPERIMENT: 05217 TEST: 99 PAGE 21
STATISTICAL ANALYSIS OF PRIMARY TUMORS IN RATS(FISCHER344) -- T-BUTYLHYDROQUINONE
MALE TERMINAL SACRIFICE AT 123 WEEKS
FEMALE TERMINAL SACRIFICE AT 129 WEEKS
|=================================================================================================================================|
| | | |
| | MALES | FEMALES |
| | | |
|DOSE | UNTREATD RTD UNTR | UNTREATD RTD UNTR |
| | CONTROL CONTROL | CONTROL CONTROL |
|=================================================================================================================================|
| |
|Testes |
| Adenoma |
| |
|---------------------------------------------------------------------------------------------------------------------------------|
|TUMOR RATES | | |
|----------- | | |
|OVERALL (a) | 55/60 (92%) 59/60 (98%) | |
|ADJUSTED (b) | 100.0% 100.0% | |
|TERMINAL (d) | 8/8 (100%) 13/13 (100%) | |
|FIRST INCIDENCE (DAYS) | 489 484 | |
|-----------------------| | |
|STATISTICAL TESTS (f) | | |
|-----------------------| | |
|LIFE TABLE | P=0.113N | |
|INCIDENTAL TUMOR | P=0.228 | |
|LOGISTIC REGRESSION | P=0.185 | |
|COCHRAN-ARMITAGE | | |
|FISHER EXACT | P=0.103 | |
|=================================================================================================================================|
| |
|Thyroid Gland: C-Cell |
| Adenoma |
| |
|---------------------------------------------------------------------------------------------------------------------------------|
|TUMOR RATES | | |
|----------- | | |
|OVERALL (a) | 5/60 (8%) 7/60 (12%) | 7/60 (12%) 3/60 (5%) |
|ADJUSTED (b) | 25.2% 28.3% | 44.9% 11.4% |
|TERMINAL (d) | 0/8 (0%) 2/13 (15%) | 4/10 (40%) 1/18 (6%) |
|FIRST INCIDENCE (DAYS) | 730 604 | 540 677 |
|-----------------------| | |
|STATISTICAL TESTS (f) | | |
|-----------------------| | |
|LIFE TABLE | P=0.598N | P=0.040N* |
|INCIDENTAL TUMOR | P=0.486 | P=0.096N |
|LOGISTIC REGRESSION | P=0.442 | P=0.090N |
|COCHRAN-ARMITAGE | | |
|FISHER EXACT | P=0.381 | P=0.161N |
|=================================================================================================================================|
DATE: 04/11/95 EXPERIMENT: 05217 TEST: 99 PAGE 22
STATISTICAL ANALYSIS OF PRIMARY TUMORS IN RATS(FISCHER344) -- T-BUTYLHYDROQUINONE
MALE TERMINAL SACRIFICE AT 123 WEEKS
FEMALE TERMINAL SACRIFICE AT 129 WEEKS
|=================================================================================================================================|
| | | |
| | MALES | FEMALES |
| | | |
|DOSE | UNTREATD RTD UNTR | UNTREATD RTD UNTR |
| | CONTROL CONTROL | CONTROL CONTROL |
|=================================================================================================================================|
| |
|Thyroid Gland: C-Cell |
| Carcinoma or Adenoma |
| |
|---------------------------------------------------------------------------------------------------------------------------------|
|TUMOR RATES | | |
|----------- | | |
|OVERALL (a) | 5/60 (8%) 7/60 (12%) | 8/60 (13%) 3/60 (5%) |
|ADJUSTED (b) | 25.2% 28.3% | 54.1% 11.4% |
|TERMINAL (d) | 0/8 (0%) 2/13 (15%) | 5/10 (50%) 1/18 (6%) |
|FIRST INCIDENCE (DAYS) | 730 604 | 540 677 |
|-----------------------| | |
|STATISTICAL TESTS (f) | | |
|-----------------------| | |
|LIFE TABLE | P=0.598N | P=0.017N* |
|INCIDENTAL TUMOR | P=0.486 | P=0.045N* |
|LOGISTIC REGRESSION | P=0.442 | P=0.044N* |
|COCHRAN-ARMITAGE | | |
|FISHER EXACT | P=0.381 | P=0.102N |
|=================================================================================================================================|
| |
|Thyroid Gland: Follicular Cell |
| Carcinoma |
| |
|---------------------------------------------------------------------------------------------------------------------------------|
|TUMOR RATES | | |
|----------- | | |
|OVERALL (a) | 0/60 (0%) 2/60 (3%) | 1/60 (2%) 0/60 (0%) |
|ADJUSTED (b) | 0.0% 10.3% | 10.0% 0.0% |
|TERMINAL (d) | 0/8 (0%) 1/13 (8%) | 1/10 (10%) 0/18 (0%) |
|FIRST INCIDENCE (DAYS) | --- 732 | 898 (T) --- |
|-----------------------| | |
|STATISTICAL TESTS (f) | | |
|-----------------------| | |
|LIFE TABLE | P=0.320 | P=0.383N |
|INCIDENTAL TUMOR | P=0.275 | P=0.383N |
|LOGISTIC REGRESSION | P=0.289 | P=0.383N |
|COCHRAN-ARMITAGE | | |
|FISHER EXACT | P=0.248 | P=0.500N |
|=================================================================================================================================|
DATE: 04/11/95 EXPERIMENT: 05217 TEST: 99 PAGE 23
STATISTICAL ANALYSIS OF PRIMARY TUMORS IN RATS(FISCHER344) -- T-BUTYLHYDROQUINONE
MALE TERMINAL SACRIFICE AT 123 WEEKS
FEMALE TERMINAL SACRIFICE AT 129 WEEKS
|=================================================================================================================================|
| | | |
| | MALES | FEMALES |
| | | |
|DOSE | UNTREATD RTD UNTR | UNTREATD RTD UNTR |
| | CONTROL CONTROL | CONTROL CONTROL |
|=================================================================================================================================|
| |
|Uterus |
| Polyp Stromal |
| |
|---------------------------------------------------------------------------------------------------------------------------------|
|TUMOR RATES | | # # |
|----------- | | |
|OVERALL (a) | | 7/60 (12%) 8/60 (13%) |
|ADJUSTED (b) | | 28.7% 21.2% |
|TERMINAL (d) | | 1/10 (10%) 1/18 (6%) |
|FIRST INCIDENCE (DAYS) | | 649 562 |
|-----------------------| | |
|STATISTICAL TESTS (f) | | |
|-----------------------| | |
|LIFE TABLE | | P=0.428N |
|INCIDENTAL TUMOR | | P=0.574 |
|LOGISTIC REGRESSION | | P=0.513 |
|COCHRAN-ARMITAGE | | |
|FISHER EXACT | | P=0.500 |
|=================================================================================================================================|
| |
|Uterus |
| Sarcoma Stromal |
| |
|---------------------------------------------------------------------------------------------------------------------------------|
|TUMOR RATES | | # # |
|----------- | | |
|OVERALL (a) | | 2/60 (3%) 0/60 (0%) |
|ADJUSTED (b) | | 8.7% 0.0% |
|TERMINAL (d) | | 0/10 (0%) 0/18 (0%) |
|FIRST INCIDENCE (DAYS) | | 302 --- |
|-----------------------| | |
|STATISTICAL TESTS (f) | | |
|-----------------------| | |
|LIFE TABLE | | P=0.168N |
|INCIDENTAL TUMOR | | P=0.494N |
|LOGISTIC REGRESSION | | P=0.427N |
|COCHRAN-ARMITAGE | | |
|FISHER EXACT | | P=0.248N |
|=================================================================================================================================|
DATE: 04/11/95 EXPERIMENT: 05217 TEST: 99 PAGE 24
STATISTICAL ANALYSIS OF PRIMARY TUMORS IN RATS(FISCHER344) -- T-BUTYLHYDROQUINONE
MALE TERMINAL SACRIFICE AT 123 WEEKS
FEMALE TERMINAL SACRIFICE AT 129 WEEKS
|=================================================================================================================================|
| | | |
| | MALES | FEMALES |
| | | |
|DOSE | UNTREATD RTD UNTR | UNTREATD RTD UNTR |
| | CONTROL CONTROL | CONTROL CONTROL |
|=================================================================================================================================|
| |
|Uterus |
| Sarcoma Stromal or Polyp Stromal |
| |
|---------------------------------------------------------------------------------------------------------------------------------|
|TUMOR RATES | | # # |
|----------- | | |
|OVERALL (a) | | 9/60 (15%) 8/60 (13%) |
|ADJUSTED (b) | | 34.9% 21.2% |
|TERMINAL (d) | | 1/10 (10%) 1/18 (6%) |
|FIRST INCIDENCE (DAYS) | | 302 562 |
|-----------------------| | |
|STATISTICAL TESTS (f) | | |
|-----------------------| | |
|LIFE TABLE | | P=0.227N |
|INCIDENTAL TUMOR | | P=0.534N |
|LOGISTIC REGRESSION | | P=0.572N |
|COCHRAN-ARMITAGE | | |
|FISHER EXACT | | P=0.500N |
|=================================================================================================================================|
| |
|Zymbal's Gland |
| Carcinoma |
| |
|---------------------------------------------------------------------------------------------------------------------------------|
|TUMOR RATES | # # | # # |
|----------- | | |
|OVERALL (a) | 2/60 (3%) 0/60 (0%) | 0/60 (0%) 1/60 (2%) |
|ADJUSTED (b) | 9.9% 0.0% | 0.0% 2.7% |
|TERMINAL (d) | 0/8 (0%) 0/13 (0%) | 0/10 (0%) 0/18 (0%) |
|FIRST INCIDENCE (DAYS) | 500 --- | --- 808 |
|-----------------------| | |
|STATISTICAL TESTS (f) | | |
|-----------------------| | |
|LIFE TABLE | P=0.176N | P=0.633 |
|INCIDENTAL TUMOR | P=0.440N | P=0.506 |
|LOGISTIC REGRESSION | P=0.283N | P=0.537 |
|COCHRAN-ARMITAGE | | |
|FISHER EXACT | P=0.248N | P=0.500 |
|=================================================================================================================================|
DATE: 04/11/95 EXPERIMENT: 05217 TEST: 99 PAGE 25
STATISTICAL ANALYSIS OF PRIMARY TUMORS IN RATS(FISCHER344) -- T-BUTYLHYDROQUINONE
MALE TERMINAL SACRIFICE AT 123 WEEKS
FEMALE TERMINAL SACRIFICE AT 129 WEEKS
|=================================================================================================================================|
| | | |
| | MALES | FEMALES |
| | | |
|DOSE | UNTREATD RTD UNTR | UNTREATD RTD UNTR |
| | CONTROL CONTROL | CONTROL CONTROL |
|=================================================================================================================================|
| |
|All Organs |
| Hemangiosarcoma or Hemangioma |
| |
|---------------------------------------------------------------------------------------------------------------------------------|
|TUMOR RATES | # # | # # |
|----------- | | |
|OVERALL (a) | 2/60 (3%) 0/60 (0%) | 1/60 (2%) 0/60 (0%) |
|ADJUSTED (b) | 14.3% 0.0% | 10.0% 0.0% |
|TERMINAL (d) | 1/8 (13%) 0/13 (0%) | 1/10 (10%) 0/18 (0%) |
|FIRST INCIDENCE (DAYS) | 626 --- | 898 (T) --- |
|-----------------------| | |
|STATISTICAL TESTS (f) | | |
|-----------------------| | |
|LIFE TABLE | P=0.181N | P=0.383N |
|INCIDENTAL TUMOR | P=0.129N | P=0.383N |
|LOGISTIC REGRESSION | P=0.225N | P=0.383N |
|COCHRAN-ARMITAGE | | |
|FISHER EXACT | P=0.248N | P=0.500N |
|=================================================================================================================================|
| |
|All Organs |
| Leukemia: Lymphocytic, Monocytic, Mononuclear, or Undifferentiated |
| |
|---------------------------------------------------------------------------------------------------------------------------------|
|TUMOR RATES | # # | # # |
|----------- | | |
|OVERALL (a) | 39/60 (65%) 46/60 (77%) | 27/60 (45%) 37/60 (62%) |
|ADJUSTED (b) | 87.2% 86.9% | 76.5% 74.3% |
|TERMINAL (d) | 4/8 (50%) 7/13 (54%) | 5/10 (50%) 8/18 (44%) |
|FIRST INCIDENCE (DAYS) | 534 484 | 421 504 |
|-----------------------| | |
|STATISTICAL TESTS (f) | | |
|-----------------------| | |
|LIFE TABLE | P=0.331N | P=0.428N |
|INCIDENTAL TUMOR | P=0.103 | P=0.058 |
|LOGISTIC REGRESSION | P=0.099 | P=0.036 * |
|COCHRAN-ARMITAGE | | |
|FISHER EXACT | P=0.114 | P=0.050 * |
|=================================================================================================================================|
DATE: 04/11/95 EXPERIMENT: 05217 TEST: 99 PAGE 26
STATISTICAL ANALYSIS OF PRIMARY TUMORS IN RATS(FISCHER344) -- T-BUTYLHYDROQUINONE
MALE TERMINAL SACRIFICE AT 123 WEEKS
FEMALE TERMINAL SACRIFICE AT 129 WEEKS
|=================================================================================================================================|
| | | |
| | MALES | FEMALES |
| | | |
|DOSE | UNTREATD RTD UNTR | UNTREATD RTD UNTR |
| | CONTROL CONTROL | CONTROL CONTROL |
|=================================================================================================================================|
| |
|All Organs |
| Malignant Lymphoma And Histiocytic Sarcoma |
| |
|---------------------------------------------------------------------------------------------------------------------------------|
|TUMOR RATES | # # | # # |
|----------- | | |
|OVERALL (a) | 2/60 (3%) 0/60 (0%) | 0/60 (0%) 0/60 (0%) |
|ADJUSTED (b) | 12.8% 0.0% | 0.0% 0.0% |
|TERMINAL (d) | 0/8 (0%) 0/13 (0%) | 0/10 (0%) 0/18 (0%) |
|FIRST INCIDENCE (DAYS) | 563 --- | --- --- |
|-----------------------| | |
|STATISTICAL TESTS (f) | | |
|-----------------------| | |
|LIFE TABLE | P=0.162N | (e) (e) |
|INCIDENTAL TUMOR | P=0.187N | (e) (e) |
|LOGISTIC REGRESSION | P=0.253N | (e) (e) |
|COCHRAN-ARMITAGE | | |
|FISHER EXACT | P=0.248N | (e) |
|=================================================================================================================================|
| |
|All Organs |
| Mesothelioma: Benign, Malignant, NOS |
| |
|---------------------------------------------------------------------------------------------------------------------------------|
|TUMOR RATES | # # | # # |
|----------- | | |
|OVERALL (a) | 1/60 (2%) 3/60 (5%) | 1/60 (2%) 0/60 (0%) |
|ADJUSTED (b) | 12.5% 6.0% | 1.7% 0.0% |
|TERMINAL (d) | 1/8 (13%) 0/13 (0%) | 0/10 (0%) 0/18 (0%) |
|FIRST INCIDENCE (DAYS) | 857 (T) 552 | 380 --- |
|-----------------------| | |
|STATISTICAL TESTS (f) | | |
|-----------------------| | |
|LIFE TABLE | P=0.379 | P=0.493N |
|INCIDENTAL TUMOR | P=0.452 | P=0.872N |
|LOGISTIC REGRESSION | P=0.258 | P=0.975N |
|COCHRAN-ARMITAGE | | |
|FISHER EXACT | P=0.309 | P=0.500N |
|=================================================================================================================================|
DATE: 04/11/95 EXPERIMENT: 05217 TEST: 99 PAGE 27
STATISTICAL ANALYSIS OF PRIMARY TUMORS IN RATS(FISCHER344) -- T-BUTYLHYDROQUINONE
MALE TERMINAL SACRIFICE AT 123 WEEKS
FEMALE TERMINAL SACRIFICE AT 129 WEEKS
|=================================================================================================================================|
| | | |
| | MALES | FEMALES |
| | | |
|DOSE | UNTREATD RTD UNTR | UNTREATD RTD UNTR |
| | CONTROL CONTROL | CONTROL CONTROL |
|=================================================================================================================================|
| |
|All Organs |
| Benign Tumors |
| |
|---------------------------------------------------------------------------------------------------------------------------------|
|TUMOR RATES | # # | # # |
|----------- | | |
|OVERALL (a) | 60/60 (100%) 59/60 (98%) | 52/60 (87%) 46/60 (77%) |
|ADJUSTED (b) | 100.0% 100.0% | 100.0% 95.6% |
|TERMINAL (d) | 8/8 (100%) 13/13 (100%) | 10/10 (100%) 16/18 (89%) |
|FIRST INCIDENCE (DAYS) | 381 484 | 418 562 |
|-----------------------| | |
|STATISTICAL TESTS (f) | | |
|-----------------------| | |
|LIFE TABLE | P=0.042N* | P<0.001N** |
|INCIDENTAL TUMOR | P=0.472N | P=0.002N** |
|LOGISTIC REGRESSION | P=0.493N | P=0.001N** |
|COCHRAN-ARMITAGE | | |
|FISHER EXACT | P=0.500N | P=0.119N |
|=================================================================================================================================|
| |
|All Organs |
| Malignant Tumors |
| |
|---------------------------------------------------------------------------------------------------------------------------------|
|TUMOR RATES | # # | # # |
|----------- | | |
|OVERALL (a) | 51/60 (85%) 52/60 (87%) | 41/60 (68%) 40/60 (67%) |
|ADJUSTED (b) | 95.5% 94.0% | 100.0% 76.7% |
|TERMINAL (d) | 6/8 (75%) 10/13 (77%) | 10/10 (100%) 8/18 (44%) |
|FIRST INCIDENCE (DAYS) | 381 484 | 302 504 |
|-----------------------| | |
|STATISTICAL TESTS (f) | | |
|-----------------------| | |
|LIFE TABLE | P=0.098N | P=0.029N* |
|INCIDENTAL TUMOR | P=0.570 | P=0.569 |
|LOGISTIC REGRESSION | P=0.440 | P=0.545 |
|COCHRAN-ARMITAGE | | |
|FISHER EXACT | P=0.500 | P=0.500N |
|=================================================================================================================================|
DATE: 04/11/95 EXPERIMENT: 05217 TEST: 99 PAGE 28
STATISTICAL ANALYSIS OF PRIMARY TUMORS IN RATS(FISCHER344) -- T-BUTYLHYDROQUINONE
MALE TERMINAL SACRIFICE AT 123 WEEKS
FEMALE TERMINAL SACRIFICE AT 129 WEEKS
|=================================================================================================================================|
| | | |
| | MALES | FEMALES |
| | | |
|DOSE | UNTREATD RTD UNTR | UNTREATD RTD UNTR |
| | CONTROL CONTROL | CONTROL CONTROL |
|=================================================================================================================================|
| |
|All Organs |
| Malignant and Benign Tumors |
| |
|---------------------------------------------------------------------------------------------------------------------------------|
|TUMOR RATES | # # | # # |
|----------- | | |
|OVERALL (a) | 60/60 (100%) 59/60 (98%) | 59/60 (98%) 59/60 (98%) |
|ADJUSTED (b) | 100.0% 100.0% | 100.0% 98.3% |
|TERMINAL (d) | 8/8 (100%) 13/13 (100%) | 10/10 (100%) 17/18 (94%) |
|FIRST INCIDENCE (DAYS) | 381 484 | 302 504 |
|-----------------------| | |
|STATISTICAL TESTS (f) | | |
|-----------------------| | |
|LIFE TABLE | P=0.042N* | P=0.008N** |
|INCIDENTAL TUMOR | P=0.472N | P=0.617N |
|LOGISTIC REGRESSION | P=0.493N | P=0.599N |
|COCHRAN-ARMITAGE | | |
|FISHER EXACT | P=0.500N | P=0.752N |
|=================================================================================================================================|
0 (a) Number of tumor-bearing animals / number of animals examined at site.
(b) Kaplan-Meier estimated lifetime tumor incidence after adjustment for
intercurrent mortality.
(d) Observed incidence at terminal kill.
(f) Beneath the control incidence are the P-values associated with the trend
test. Beneath the dosed group incidence are the P-values corresponding to
pairwise comparisons between the controls and that dosed group. The life
table analysis regards tumors in animals dying prior to terminal kill as
being (directly or indirectly) the cause of death. The incidental tumor
test regards these lesions as non-fatal. Logistic regression is an alternative
method for analyzing the incidence of non-fatal tumors. The Cochran-Armitage
and Fisher's exact tests compare directly the overall incidence rates.
For all tests, a negative trend is indicated by "N".
(e) Value of Statistic cannot be computed.
(I) Interim sacrifice
(T) Terminal sacrifice
# Tumor rates based on number of animals necropsied.
0 * To the right of any statistical result, indicates significance at (P<=0.05).
** To the right of any statistical result, indicates significance at (P<=0.01).