TDMS Study 97013-13 Pathology Tables
NTP Experiment-Test: 97013-13 INCIDENCE RATES OF NONNEOPLASTIC LESIONS BY ANATOMIC SITE (a) Report: PEIRPT18 Study Type: SUBCHRON 26-WEEK WITH AVERAGE SEVERITY GRADES[b] Date: 01/27/05 Route: DOSED WATER WATER DISINFECTION MODEL (DICHLOROACETIC ACID) Time: 10:04:03 FINAL #1/TGAC MICE Facility: Battelle Columbus Laboratory Chemical CAS #: 79-43-6 Lock Date: 07/31/01 Cage Range: All Reasons For Removal: 25019 Moribund Sacrifice 25020 Natural Death 25021 Terminal Sacrifice Removal Date Range: All Treatment Groups: Include 001 0 MG/L Include 002 0 MG/L Include 003 500 MG/L Include 004 500 MG/L Include 005 1000MG/L Include 006 1000MG/L Include 007 2000MG/L Include 008 2000MG/L a Number of animals examined microscopically at site and number of animals with lesion b Average severity grade (1-minimal;2-mild;3-moderate;4-marked) Page 1 NTP Experiment-Test: 97013-13 INCIDENCE RATES OF NONNEOPLASTIC LESIONS BY ANATOMIC SITE (a) Report: PEIRPT18 Study Type: SUBCHRON 26-WEEK WITH AVERAGE SEVERITY GRADES[b] Date: 01/27/05 Route: DOSED WATER WATER DISINFECTION MODEL (DICHLOROACETIC ACID) Time: 10:04:03 ____________________________________________________________________________________________________________________________________ TGAC (FVB/N) HEMIZYGOUS FEMALE 0 MG/L 500 MG/L 1000MG/L 2000MG/L ____________________________________________________________________________________________________________________________________ DISPOSITION SUMMARY Animals Initially In Study 15 15 15 15 Early Deaths Moribund Sacrifice 4 1 4 Natural Death 3 1 1 Survivors Terminal Sacrifice 15 8 13 10 Animals Examined Microscopically 15 15 15 15 ____________________________________________________________________________________________________________________________________ ALIMENTARY SYSTEM Liver (15) (15) (15) (15) Hematopoietic Cell Proliferation 2 [1.0] Inflammation, Chronic Active 14 [1.4] 10 [1.2] 12 [1.1] 12 [1.1] Hepatocyte, Fatty Change 2 [1.0] 3 [1.7] Hepatocyte, Necrosis 1 [1.0] 5 [1.4] 1 [2.0] 3 [1.3] Hepatocyte, Vacuolization Cytoplasmic 6 [1.3] 10 [2.7] 14 [3.1] 14 [3.7] Stomach, Forestomach (15) (15) (15) (15) Epithelium, Hyperkeratosis 5 [1.8] 1 [2.0] 1 [2.0] Epithelium, Hyperplasia 2 [2.0] 5 [2.0] 2 [2.0] 2 [2.5] ____________________________________________________________________________________________________________________________________ CARDIOVASCULAR SYSTEM None ____________________________________________________________________________________________________________________________________ ENDOCRINE SYSTEM Adrenal Cortex (15) (15) (15) (15) Accessory Adrenal Cortical Nodule 2 [1.0] 5 [1.2] 4 [1.5] 7 [1.1] Subcapsular, Hyperplasia 10 [1.0] 7 [1.0] 3 [1.0] 9 [1.0] Pituitary Gland (15) (14) (15) (15) Pars Distalis, Cyst 1 [1.0] 3 [1.0] 4 [1.0] Thyroid Gland (15) (15) (15) (15) Follicle, Degeneration 4 [1.0] 4 [1.0] 4 [1.0] 3 [1.0] ____________________________________________________________________________________________________________________________________ GENERAL BODY SYSTEM None a Number of animals examined microscopically at site and number of animals with lesion b Average severity grade (1-minimal;2-mild;3-moderate;4-marked) Page 2 NTP Experiment-Test: 97013-13 INCIDENCE RATES OF NONNEOPLASTIC LESIONS BY ANATOMIC SITE (a) Report: PEIRPT18 Study Type: SUBCHRON 26-WEEK WITH AVERAGE SEVERITY GRADES[b] Date: 01/27/05 Route: DOSED WATER WATER DISINFECTION MODEL (DICHLOROACETIC ACID) Time: 10:04:03 ____________________________________________________________________________________________________________________________________ TGAC (FVB/N) HEMIZYGOUS FEMALE 0 MG/L 500 MG/L 1000MG/L 2000MG/L ____________________________________________________________________________________________________________________________________ GENITAL SYSTEM Ovary (15) (15) (15) (15) Cyst 1 [2.0] 1 [2.0] 1 [1.0] 2 [3.0] Inflammation, Chronic Active 1 [2.0] Pigmentation, Hemosiderin 1 [2.0] Uterus (15) (15) (15) (15) Endometrium, Hyperplasia, Cystic 9 [1.9] 8 [1.3] 10 [1.7] 5 [1.4] ____________________________________________________________________________________________________________________________________ HEMATOPOIETIC SYSTEM Lymph Node, Mandibular (15) (14) (15) (15) Hyperplasia, Lymphoid 3 [2.3] 2 [2.0] 3 [2.3] 2 [2.5] Spleen (15) (15) (15) (15) Atrophy 1 [3.0] 1 [2.0] Hematopoietic Cell Proliferation 1 [2.0] 1 [2.0] Necrosis 1 [4.0] Thymus (15) (15) (15) (15) Atrophy 1 [3.0] 4 [3.5] 3 [3.0] 3 [2.7] Cyst 4 [1.3] 3 [1.3] 4 [1.5] 1 [2.0] ____________________________________________________________________________________________________________________________________ INTEGUMENTARY SYSTEM Skin (4) (4) (2) (8) Hyperkeratosis 1 [3.0] Epidermis, Hyperplasia 1 [3.0] 4 [2.8] ____________________________________________________________________________________________________________________________________ MUSCULOSKELETAL SYSTEM None ____________________________________________________________________________________________________________________________________ NERVOUS SYSTEM None ____________________________________________________________________________________________________________________________________ RESPIRATORY SYSTEM Lung (15) (15) (15) (15) a Number of animals examined microscopically at site and number of animals with lesion b Average severity grade (1-minimal;2-mild;3-moderate;4-marked) Page 3 NTP Experiment-Test: 97013-13 INCIDENCE RATES OF NONNEOPLASTIC LESIONS BY ANATOMIC SITE (a) Report: PEIRPT18 Study Type: SUBCHRON 26-WEEK WITH AVERAGE SEVERITY GRADES[b] Date: 01/27/05 Route: DOSED WATER WATER DISINFECTION MODEL (DICHLOROACETIC ACID) Time: 10:04:03 ____________________________________________________________________________________________________________________________________ TGAC (FVB/N) HEMIZYGOUS FEMALE 0 MG/L 500 MG/L 1000MG/L 2000MG/L ____________________________________________________________________________________________________________________________________ RESPIRATORY SYSTEM - CONT Inflammation, Chronic Active 1 [1.0] ____________________________________________________________________________________________________________________________________ SPECIAL SENSES SYSTEM None ____________________________________________________________________________________________________________________________________ URINARY SYSTEM Kidney (15) (15) (15) (15) Inflammation, Chronic Active 1 [2.0] 1 [3.0] Necrosis 1 [2.0] Nephropathy 5 [1.0] 6 [1.0] 5 [1.0] 7 [1.1] Cortex, Cyst 1 [2.0] Papilla, Necrosis 1 [3.0] Renal Tubule, Dilatation 3 [2.0] 1 [1.0] 1 [2.0] a Number of animals examined microscopically at site and number of animals with lesion b Average severity grade (1-minimal;2-mild;3-moderate;4-marked) Page 4 NTP Experiment-Test: 97013-13 INCIDENCE RATES OF NONNEOPLASTIC LESIONS BY ANATOMIC SITE (a) Report: PEIRPT18 Study Type: SUBCHRON 26-WEEK WITH AVERAGE SEVERITY GRADES[b] Date: 01/27/05 Route: DOSED WATER WATER DISINFECTION MODEL (DICHLOROACETIC ACID) Time: 10:04:03 ____________________________________________________________________________________________________________________________________ TGAC (FVB/N) HEMIZYGOUS MALE 0 MG/L 500 MG/L 1000MG/L 2000MG/L ____________________________________________________________________________________________________________________________________ DISPOSITION SUMMARY Animals Initially In Study 15 15 15 15 Early Deaths Moribund Sacrifice 1 2 4 1 Survivors Terminal Sacrifice 14 13 11 14 Animals Examined Microscopically 15 15 15 15 ____________________________________________________________________________________________________________________________________ ALIMENTARY SYSTEM Liver (15) (15) (15) (15) Hematopoietic Cell Proliferation 3 [1.0] 2 [1.0] 1 [2.0] Inflammation, Chronic Active 9 [1.0] 13 [1.2] 12 [1.1] 11 [1.0] Hepatocyte, Fatty Change 3 [1.0] 1 [1.0] Hepatocyte, Necrosis 1 [1.0] 1 [1.0] Hepatocyte, Vacuolization Cytoplasmic 7 [1.0] 13 [1.8] 15 [2.7] 15 [3.7] Mesentery (1) (1) (2) Fat, Fibrosis 1 [2.0] 1 [2.0] Fat, Hemorrhage 1 [2.0] 1 [2.0] 2 [2.0] Fat, Inflammation, Chronic Active 1 [2.0] 1 [2.0] 2 [2.0] Fat, Necrosis 1 [4.0] 1 [4.0] 2 [4.0] Stomach, Forestomach (15) (15) (15) (15) Inflammation, Chronic Active 1 [2.0] Epithelium, Hyperkeratosis 1 [2.0] 1 [2.0] Epithelium, Hyperplasia 2 [1.0] 4 [2.0] 3 [2.0] 6 [2.0] Stomach, Glandular (1) Glands, Ectasia 1 [2.0] ____________________________________________________________________________________________________________________________________ CARDIOVASCULAR SYSTEM None ____________________________________________________________________________________________________________________________________ ENDOCRINE SYSTEM Adrenal Cortex (15) (15) (15) (15) Accessory Adrenal Cortical Nodule 1 [1.0] 1 [1.0] 2 [2.0] Hypertrophy 8 [1.1] 9 [1.7] 8 [1.4] 8 [1.3] Subcapsular, Hyperplasia 2 [1.0] 2 [1.0] Pituitary Gland (14) (15) (15) (15) a Number of animals examined microscopically at site and number of animals with lesion b Average severity grade (1-minimal;2-mild;3-moderate;4-marked) Page 5 NTP Experiment-Test: 97013-13 INCIDENCE RATES OF NONNEOPLASTIC LESIONS BY ANATOMIC SITE (a) Report: PEIRPT18 Study Type: SUBCHRON 26-WEEK WITH AVERAGE SEVERITY GRADES[b] Date: 01/27/05 Route: DOSED WATER WATER DISINFECTION MODEL (DICHLOROACETIC ACID) Time: 10:04:03 ____________________________________________________________________________________________________________________________________ TGAC (FVB/N) HEMIZYGOUS MALE 0 MG/L 500 MG/L 1000MG/L 2000MG/L ____________________________________________________________________________________________________________________________________ ENDOCRINE SYSTEM - CONT Pars Distalis, Cyst 1 [1.0] 1 [1.0] 1 [1.0] 1 [1.0] Thyroid Gland (15) (15) (15) (15) Infiltration Cellular, Lymphocyte 1 [1.0] Follicle, Degeneration 7 [1.0] 8 [1.0] 5 [1.0] 5 [1.0] ____________________________________________________________________________________________________________________________________ GENERAL BODY SYSTEM None ____________________________________________________________________________________________________________________________________ GENITAL SYSTEM Epididymis (15) (15) (15) (15) Degeneration 2 [4.0] 2 [4.0] 2 [4.0] 2 [4.0] Preputial Gland (2) (1) Duct, Ectasia 2 [2.5] 1 [4.0] Seminal Vesicle (1) Inflammation, Chronic Active 1 [1.0] Testes (15) (15) (15) (15) Cyst 1 [2.0] 1 [2.0] 1 [2.0] 1 [2.0] Germinal Epithelium, Degeneration 2 [3.5] 2 [2.5] 1 [2.0] 2 [3.0] ____________________________________________________________________________________________________________________________________ HEMATOPOIETIC SYSTEM Lymph Node, Mandibular (15) (14) (15) (14) Hyperplasia, Lymphoid 1 [2.0] 3 [2.7] 2 [2.0] Spleen (15) (15) (15) (15) Hematopoietic Cell Proliferation 2 [2.0] 1 [2.0] Thymus (15) (15) (14) (14) Atrophy 1 [3.0] 3 [3.0] 4 [2.8] Cyst 1 [1.0] 2 [1.5] 1 [1.0] 2 [1.5] ____________________________________________________________________________________________________________________________________ INTEGUMENTARY SYSTEM Skin (4) (4) (4) (6) Inflammation, Chronic Active 1 [2.0] Epidermis, Hyperplasia 1 [2.0] ____________________________________________________________________________________________________________________________________ MUSCULOSKELETAL SYSTEM a Number of animals examined microscopically at site and number of animals with lesion b Average severity grade (1-minimal;2-mild;3-moderate;4-marked) Page 6 NTP Experiment-Test: 97013-13 INCIDENCE RATES OF NONNEOPLASTIC LESIONS BY ANATOMIC SITE (a) Report: PEIRPT18 Study Type: SUBCHRON 26-WEEK WITH AVERAGE SEVERITY GRADES[b] Date: 01/27/05 Route: DOSED WATER WATER DISINFECTION MODEL (DICHLOROACETIC ACID) Time: 10:04:03 ____________________________________________________________________________________________________________________________________ TGAC (FVB/N) HEMIZYGOUS MALE 0 MG/L 500 MG/L 1000MG/L 2000MG/L ____________________________________________________________________________________________________________________________________ None ____________________________________________________________________________________________________________________________________ NERVOUS SYSTEM None ____________________________________________________________________________________________________________________________________ RESPIRATORY SYSTEM Lung (15) (15) (15) (15) Inflammation, Chronic Active 4 [1.3] 2 [2.5] 1 [1.0] Alveolar Epithelium, Hyperplasia 1 [2.0] 1 [2.0] ____________________________________________________________________________________________________________________________________ SPECIAL SENSES SYSTEM None ____________________________________________________________________________________________________________________________________ URINARY SYSTEM Kidney (15) (15) (15) (15) Inflammation, Chronic Active 1 [4.0] Necrosis 1 [2.0] Nephropathy 10 [1.0] 9 [1.0] 12 [1.1] 14 [1.0] Renal Tubule, Dilatation 1 [2.0] 2 [1.5] a Number of animals examined microscopically at site and number of animals with lesion b Average severity grade (1-minimal;2-mild;3-moderate;4-marked) Page 7 ------------------------------------------------------------ ---------- END OF REPORT ---------- ------------------------------------------------------------