TDMS Study 97013-13 Pathology Tables
NTP Experiment-Test: 97013-13 INCIDENCE RATES OF NONNEOPLASTIC LESIONS BY ANATOMIC SITE (a) Report: PEIRPT18
Study Type: SUBCHRON 26-WEEK WITH AVERAGE SEVERITY GRADES[b] Date: 01/27/05
Route: DOSED WATER WATER DISINFECTION MODEL (DICHLOROACETIC ACID) Time: 10:04:03
FINAL #1/TGAC MICE
Facility: Battelle Columbus Laboratory
Chemical CAS #: 79-43-6
Lock Date: 07/31/01
Cage Range: All
Reasons For Removal: 25019 Moribund Sacrifice 25020 Natural Death
25021 Terminal Sacrifice
Removal Date Range: All
Treatment Groups: Include 001 0 MG/L
Include 002 0 MG/L
Include 003 500 MG/L
Include 004 500 MG/L
Include 005 1000MG/L
Include 006 1000MG/L
Include 007 2000MG/L
Include 008 2000MG/L
a Number of animals examined microscopically at site and number of animals with lesion
b Average severity grade (1-minimal;2-mild;3-moderate;4-marked)
Page 1
NTP Experiment-Test: 97013-13 INCIDENCE RATES OF NONNEOPLASTIC LESIONS BY ANATOMIC SITE (a) Report: PEIRPT18
Study Type: SUBCHRON 26-WEEK WITH AVERAGE SEVERITY GRADES[b] Date: 01/27/05
Route: DOSED WATER WATER DISINFECTION MODEL (DICHLOROACETIC ACID) Time: 10:04:03
____________________________________________________________________________________________________________________________________
TGAC (FVB/N) HEMIZYGOUS FEMALE 0 MG/L 500 MG/L 1000MG/L 2000MG/L
____________________________________________________________________________________________________________________________________
DISPOSITION SUMMARY
Animals Initially In Study 15 15 15 15
Early Deaths
Moribund Sacrifice 4 1 4
Natural Death 3 1 1
Survivors
Terminal Sacrifice 15 8 13 10
Animals Examined Microscopically 15 15 15 15
____________________________________________________________________________________________________________________________________
ALIMENTARY SYSTEM
Liver (15) (15) (15) (15)
Hematopoietic Cell Proliferation 2 [1.0]
Inflammation, Chronic Active 14 [1.4] 10 [1.2] 12 [1.1] 12 [1.1]
Hepatocyte, Fatty Change 2 [1.0] 3 [1.7]
Hepatocyte, Necrosis 1 [1.0] 5 [1.4] 1 [2.0] 3 [1.3]
Hepatocyte, Vacuolization Cytoplasmic 6 [1.3] 10 [2.7] 14 [3.1] 14 [3.7]
Stomach, Forestomach (15) (15) (15) (15)
Epithelium, Hyperkeratosis 5 [1.8] 1 [2.0] 1 [2.0]
Epithelium, Hyperplasia 2 [2.0] 5 [2.0] 2 [2.0] 2 [2.5]
____________________________________________________________________________________________________________________________________
CARDIOVASCULAR SYSTEM
None
____________________________________________________________________________________________________________________________________
ENDOCRINE SYSTEM
Adrenal Cortex (15) (15) (15) (15)
Accessory Adrenal Cortical Nodule 2 [1.0] 5 [1.2] 4 [1.5] 7 [1.1]
Subcapsular, Hyperplasia 10 [1.0] 7 [1.0] 3 [1.0] 9 [1.0]
Pituitary Gland (15) (14) (15) (15)
Pars Distalis, Cyst 1 [1.0] 3 [1.0] 4 [1.0]
Thyroid Gland (15) (15) (15) (15)
Follicle, Degeneration 4 [1.0] 4 [1.0] 4 [1.0] 3 [1.0]
____________________________________________________________________________________________________________________________________
GENERAL BODY SYSTEM
None
a Number of animals examined microscopically at site and number of animals with lesion
b Average severity grade (1-minimal;2-mild;3-moderate;4-marked)
Page 2
NTP Experiment-Test: 97013-13 INCIDENCE RATES OF NONNEOPLASTIC LESIONS BY ANATOMIC SITE (a) Report: PEIRPT18
Study Type: SUBCHRON 26-WEEK WITH AVERAGE SEVERITY GRADES[b] Date: 01/27/05
Route: DOSED WATER WATER DISINFECTION MODEL (DICHLOROACETIC ACID) Time: 10:04:03
____________________________________________________________________________________________________________________________________
TGAC (FVB/N) HEMIZYGOUS FEMALE 0 MG/L 500 MG/L 1000MG/L 2000MG/L
____________________________________________________________________________________________________________________________________
GENITAL SYSTEM
Ovary (15) (15) (15) (15)
Cyst 1 [2.0] 1 [2.0] 1 [1.0] 2 [3.0]
Inflammation, Chronic Active 1 [2.0]
Pigmentation, Hemosiderin 1 [2.0]
Uterus (15) (15) (15) (15)
Endometrium, Hyperplasia, Cystic 9 [1.9] 8 [1.3] 10 [1.7] 5 [1.4]
____________________________________________________________________________________________________________________________________
HEMATOPOIETIC SYSTEM
Lymph Node, Mandibular (15) (14) (15) (15)
Hyperplasia, Lymphoid 3 [2.3] 2 [2.0] 3 [2.3] 2 [2.5]
Spleen (15) (15) (15) (15)
Atrophy 1 [3.0] 1 [2.0]
Hematopoietic Cell Proliferation 1 [2.0] 1 [2.0]
Necrosis 1 [4.0]
Thymus (15) (15) (15) (15)
Atrophy 1 [3.0] 4 [3.5] 3 [3.0] 3 [2.7]
Cyst 4 [1.3] 3 [1.3] 4 [1.5] 1 [2.0]
____________________________________________________________________________________________________________________________________
INTEGUMENTARY SYSTEM
Skin (4) (4) (2) (8)
Hyperkeratosis 1 [3.0]
Epidermis, Hyperplasia 1 [3.0] 4 [2.8]
____________________________________________________________________________________________________________________________________
MUSCULOSKELETAL SYSTEM
None
____________________________________________________________________________________________________________________________________
NERVOUS SYSTEM
None
____________________________________________________________________________________________________________________________________
RESPIRATORY SYSTEM
Lung (15) (15) (15) (15)
a Number of animals examined microscopically at site and number of animals with lesion
b Average severity grade (1-minimal;2-mild;3-moderate;4-marked)
Page 3
NTP Experiment-Test: 97013-13 INCIDENCE RATES OF NONNEOPLASTIC LESIONS BY ANATOMIC SITE (a) Report: PEIRPT18
Study Type: SUBCHRON 26-WEEK WITH AVERAGE SEVERITY GRADES[b] Date: 01/27/05
Route: DOSED WATER WATER DISINFECTION MODEL (DICHLOROACETIC ACID) Time: 10:04:03
____________________________________________________________________________________________________________________________________
TGAC (FVB/N) HEMIZYGOUS FEMALE 0 MG/L 500 MG/L 1000MG/L 2000MG/L
____________________________________________________________________________________________________________________________________
RESPIRATORY SYSTEM - CONT
Inflammation, Chronic Active 1 [1.0]
____________________________________________________________________________________________________________________________________
SPECIAL SENSES SYSTEM
None
____________________________________________________________________________________________________________________________________
URINARY SYSTEM
Kidney (15) (15) (15) (15)
Inflammation, Chronic Active 1 [2.0] 1 [3.0]
Necrosis 1 [2.0]
Nephropathy 5 [1.0] 6 [1.0] 5 [1.0] 7 [1.1]
Cortex, Cyst 1 [2.0]
Papilla, Necrosis 1 [3.0]
Renal Tubule, Dilatation 3 [2.0] 1 [1.0] 1 [2.0]
a Number of animals examined microscopically at site and number of animals with lesion
b Average severity grade (1-minimal;2-mild;3-moderate;4-marked)
Page 4
NTP Experiment-Test: 97013-13 INCIDENCE RATES OF NONNEOPLASTIC LESIONS BY ANATOMIC SITE (a) Report: PEIRPT18
Study Type: SUBCHRON 26-WEEK WITH AVERAGE SEVERITY GRADES[b] Date: 01/27/05
Route: DOSED WATER WATER DISINFECTION MODEL (DICHLOROACETIC ACID) Time: 10:04:03
____________________________________________________________________________________________________________________________________
TGAC (FVB/N) HEMIZYGOUS MALE 0 MG/L 500 MG/L 1000MG/L 2000MG/L
____________________________________________________________________________________________________________________________________
DISPOSITION SUMMARY
Animals Initially In Study 15 15 15 15
Early Deaths
Moribund Sacrifice 1 2 4 1
Survivors
Terminal Sacrifice 14 13 11 14
Animals Examined Microscopically 15 15 15 15
____________________________________________________________________________________________________________________________________
ALIMENTARY SYSTEM
Liver (15) (15) (15) (15)
Hematopoietic Cell Proliferation 3 [1.0] 2 [1.0] 1 [2.0]
Inflammation, Chronic Active 9 [1.0] 13 [1.2] 12 [1.1] 11 [1.0]
Hepatocyte, Fatty Change 3 [1.0] 1 [1.0]
Hepatocyte, Necrosis 1 [1.0] 1 [1.0]
Hepatocyte, Vacuolization Cytoplasmic 7 [1.0] 13 [1.8] 15 [2.7] 15 [3.7]
Mesentery (1) (1) (2)
Fat, Fibrosis 1 [2.0] 1 [2.0]
Fat, Hemorrhage 1 [2.0] 1 [2.0] 2 [2.0]
Fat, Inflammation, Chronic Active 1 [2.0] 1 [2.0] 2 [2.0]
Fat, Necrosis 1 [4.0] 1 [4.0] 2 [4.0]
Stomach, Forestomach (15) (15) (15) (15)
Inflammation, Chronic Active 1 [2.0]
Epithelium, Hyperkeratosis 1 [2.0] 1 [2.0]
Epithelium, Hyperplasia 2 [1.0] 4 [2.0] 3 [2.0] 6 [2.0]
Stomach, Glandular (1)
Glands, Ectasia 1 [2.0]
____________________________________________________________________________________________________________________________________
CARDIOVASCULAR SYSTEM
None
____________________________________________________________________________________________________________________________________
ENDOCRINE SYSTEM
Adrenal Cortex (15) (15) (15) (15)
Accessory Adrenal Cortical Nodule 1 [1.0] 1 [1.0] 2 [2.0]
Hypertrophy 8 [1.1] 9 [1.7] 8 [1.4] 8 [1.3]
Subcapsular, Hyperplasia 2 [1.0] 2 [1.0]
Pituitary Gland (14) (15) (15) (15)
a Number of animals examined microscopically at site and number of animals with lesion
b Average severity grade (1-minimal;2-mild;3-moderate;4-marked)
Page 5
NTP Experiment-Test: 97013-13 INCIDENCE RATES OF NONNEOPLASTIC LESIONS BY ANATOMIC SITE (a) Report: PEIRPT18
Study Type: SUBCHRON 26-WEEK WITH AVERAGE SEVERITY GRADES[b] Date: 01/27/05
Route: DOSED WATER WATER DISINFECTION MODEL (DICHLOROACETIC ACID) Time: 10:04:03
____________________________________________________________________________________________________________________________________
TGAC (FVB/N) HEMIZYGOUS MALE 0 MG/L 500 MG/L 1000MG/L 2000MG/L
____________________________________________________________________________________________________________________________________
ENDOCRINE SYSTEM - CONT
Pars Distalis, Cyst 1 [1.0] 1 [1.0] 1 [1.0] 1 [1.0]
Thyroid Gland (15) (15) (15) (15)
Infiltration Cellular, Lymphocyte 1 [1.0]
Follicle, Degeneration 7 [1.0] 8 [1.0] 5 [1.0] 5 [1.0]
____________________________________________________________________________________________________________________________________
GENERAL BODY SYSTEM
None
____________________________________________________________________________________________________________________________________
GENITAL SYSTEM
Epididymis (15) (15) (15) (15)
Degeneration 2 [4.0] 2 [4.0] 2 [4.0] 2 [4.0]
Preputial Gland (2) (1)
Duct, Ectasia 2 [2.5] 1 [4.0]
Seminal Vesicle (1)
Inflammation, Chronic Active 1 [1.0]
Testes (15) (15) (15) (15)
Cyst 1 [2.0] 1 [2.0] 1 [2.0] 1 [2.0]
Germinal Epithelium, Degeneration 2 [3.5] 2 [2.5] 1 [2.0] 2 [3.0]
____________________________________________________________________________________________________________________________________
HEMATOPOIETIC SYSTEM
Lymph Node, Mandibular (15) (14) (15) (14)
Hyperplasia, Lymphoid 1 [2.0] 3 [2.7] 2 [2.0]
Spleen (15) (15) (15) (15)
Hematopoietic Cell Proliferation 2 [2.0] 1 [2.0]
Thymus (15) (15) (14) (14)
Atrophy 1 [3.0] 3 [3.0] 4 [2.8]
Cyst 1 [1.0] 2 [1.5] 1 [1.0] 2 [1.5]
____________________________________________________________________________________________________________________________________
INTEGUMENTARY SYSTEM
Skin (4) (4) (4) (6)
Inflammation, Chronic Active 1 [2.0]
Epidermis, Hyperplasia 1 [2.0]
____________________________________________________________________________________________________________________________________
MUSCULOSKELETAL SYSTEM
a Number of animals examined microscopically at site and number of animals with lesion
b Average severity grade (1-minimal;2-mild;3-moderate;4-marked)
Page 6
NTP Experiment-Test: 97013-13 INCIDENCE RATES OF NONNEOPLASTIC LESIONS BY ANATOMIC SITE (a) Report: PEIRPT18
Study Type: SUBCHRON 26-WEEK WITH AVERAGE SEVERITY GRADES[b] Date: 01/27/05
Route: DOSED WATER WATER DISINFECTION MODEL (DICHLOROACETIC ACID) Time: 10:04:03
____________________________________________________________________________________________________________________________________
TGAC (FVB/N) HEMIZYGOUS MALE 0 MG/L 500 MG/L 1000MG/L 2000MG/L
____________________________________________________________________________________________________________________________________
None
____________________________________________________________________________________________________________________________________
NERVOUS SYSTEM
None
____________________________________________________________________________________________________________________________________
RESPIRATORY SYSTEM
Lung (15) (15) (15) (15)
Inflammation, Chronic Active 4 [1.3] 2 [2.5] 1 [1.0]
Alveolar Epithelium, Hyperplasia 1 [2.0] 1 [2.0]
____________________________________________________________________________________________________________________________________
SPECIAL SENSES SYSTEM
None
____________________________________________________________________________________________________________________________________
URINARY SYSTEM
Kidney (15) (15) (15) (15)
Inflammation, Chronic Active 1 [4.0]
Necrosis 1 [2.0]
Nephropathy 10 [1.0] 9 [1.0] 12 [1.1] 14 [1.0]
Renal Tubule, Dilatation 1 [2.0] 2 [1.5]
a Number of animals examined microscopically at site and number of animals with lesion
b Average severity grade (1-minimal;2-mild;3-moderate;4-marked)
Page 7
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