TDMS Study 97013-14 Pathology Tables
NTP FEED, WATER, AND COMPOUND CONSUMPTION TABLE REPORT: EISRPT39 LAB: Battelle Columbus WATER DISINFECTION MODEL (DICHLOROACETIC ACID) DATE: 01/27/05 EXPERIMENT: 97013 TEST: 14 TIME: 09:11:30 CAGES FROM 0000 TO LAST CAGE PAGE: 1 TEST TYPE: SUBCHRON 26-WEEK ROUTE: DOSED WATER NTP: C97013C ------------------------------------------------------------------------------------------------------------------------------------ REASONS FOR REMOVAL: ALL REMOVAL DATE RANGE: ALL TREATMENT GROUPS: INCLUDE ALL NTP FEED, WATER, AND COMPOUND CONSUMPTION TABLE REPORT: EISRPT39 LAB: BATTELLE COLUMBUS WATER DISINFECTION MODEL (DICHLOROACETIC ACID) DATE: 01/27/05 EXPERIMENT: 97013 TEST: 14 TIME: 9:16:26 TEST TYPE: SUBCHRONIC (26-WEEK) ROUTE: DOSED WATER NTP: 97013C CONT: N01-ES-65406 CAS: 79-43-6 WATER AND COMPOUND CONSUMPTION BY MALE MICE IN THE SUBCHRONIC (26-WEEK) DOSED WATER STUDY OF WATER DISINFECTION MODEL (DICHLOROACETIC ACID) ================================================================================================================================== 0 MG/L 500 MG/L 1000MG/L 2000MG/L ---------------- --------------------------------- --------------------------------- --------------------------------- DOSE/ DOSE/ DOSE/ GRAMS BODY GRAMS BODY CONTROL GRAMS BODY CONTROL GRAMS BODY CONTROL WATER/ WEIGHT WATER/ WEIGHT WATER (B) DOSE/ WATER/ WEIGHT WATER (B) DOSE/ WATER/ WEIGHT WATER (B) DOSE/ WEEK DAY(A) (GRAMS) DAY(A) (GRAMS) (GRAMS) DAY(C) DAY(A) (GRAMS) (GRAMS) DAY(C) DAY(A) (GRAMS) (GRAMS) DAY(C) ================================================================================================================================== 2 3.3 24.1 3.2 24.0 0.97 66 2.8 23.7 0.85 118 2.4 22.8 0.73 207 3 3.0 25.1 3.0 24.8 1.00 61 2.5 23.8 0.83 106 2.2 23.6 0.73 189 4 3.0 26.4 3.0 26.2 1.00 57 2.7 25.4 0.90 107 2.1 24.3 0.70 176 5 3.1 27.8 3.0 27.6 0.97 55 2.6 26.1 0.84 100 2.1 25.1 0.68 166 6 3.1 28.9 3.0 28.5 0.97 52 2.6 26.6 0.84 97 2.1 25.5 0.68 168 7 3.1 30.7 2.9 29.8 0.94 49 2.7 27.9 0.87 95 1.9 25.9 0.61 148 8 3.1 31.9 2.9 30.7 0.94 48 2.6 28.6 0.84 93 2.2 26.5 0.71 166 9 3.1 33.3 3.1 31.7 1.00 48 2.5 29.2 0.81 87 2.1 27.1 0.68 158 10 3.3 34.7 3.1 33.2 0.94 46 2.6 29.8 0.79 86 2.1 27.4 0.64 152 11 3.2 36.2 2.9 34.0 0.91 42 2.5 30.5 0.78 82 2.1 27.9 0.66 148 12 3.4 37.4 3.1 35.2 0.91 44 2.5 31.1 0.74 81 2.0 28.4 0.59 141 13 3.3 38.6 3.1 36.2 0.94 42 2.4 31.1 0.73 78 1.9 28.6 0.58 136 14 3.6 39.5 3.3 37.1 0.92 45 2.5 31.5 0.69 79 2.1 29.2 0.58 145 15 3.5 40.9 3.0 38.4 0.86 40 2.6 32.5 0.74 80 2.0 29.4 0.57 134 16 3.5 41.4 3.1 38.6 0.89 40 2.5 32.4 0.71 77 2.3 29.5 0.66 156 17 3.8 42.1 3.1 39.8 0.82 39 2.5 33.1 0.66 76 1.9 29.4 0.50 132 18 3.6 43.4 3.0 40.6 0.83 37 2.5 33.8 0.69 73 2.1 30.5 0.58 140 19 3.6 44.6 3.2 41.7 0.89 38 2.5 34.6 0.69 73 2.0 31.1 0.56 132 20 3.6 44.9 3.1 42.2 0.86 37 2.5 35.0 0.69 71 2.0 31.5 0.56 130 21 3.6 45.5 3.0 43.2 0.83 35 2.5 35.6 0.69 70 2.1 31.8 0.58 129 22 3.5 45.8 3.0 43.5 0.86 35 2.4 35.8 0.69 67 2.1 32.2 0.60 129 23 3.7 46.2 3.1 44.0 0.84 35 2.4 36.1 0.65 66 2.0 32.4 0.54 123 24 3.6 46.7 3.2 44.4 0.89 36 2.5 36.8 0.69 67 2.1 33.1 0.58 126 25 3.7 46.9 3.0 44.6 0.81 34 2.3 36.6 0.62 64 2.0 32.3 0.54 127 1 TO 13 WEEKS ---------------- MEAN 3.2 31.3 3.0 30.2 0.96 51 2.6 27.8 0.82 94 2.1 26.1 0.66 163 SD(D) 0.1 0.1 0.03 8 0.1 0.05 12 0.1 0.05 20 CV(E) 4.0 2.6 3.5 14.8 4.0 6.3 12.9 5.8 7.8 12.5 14 TO 52 WEEKS ---------------- MEAN 3.6 44.0 3.1 41.5 0.86 37 2.5 34.5 0.69 72 2.1 31.0 0.57 134 SD(D) 0.1 0.1 0.03 3 0.1 0.03 5 0.1 0.04 9 CV(E) 2.4 2.9 3.8 8.1 2.7 4.6 7.4 4.5 6.7 6.9 ================================================================================================================================== (A) GRAMS OF WATER CONSUMED PER ANIMAL PER DAY. (B) GRAMS OF WATER PER DAY FOR THE DOSED GROUP DIVIDED BY THAT FOR THE CONTROLS. (C) MILLIGRAMS OF COMPOUND CONSUMED PER DAY PER KILOGRAM BODY WEIGHT. (D) STANDARD DEVIATION OF WEEKLY MEAN. (E) COEFFICIENT OF VARIATION = (STANDARD DEVIATION / MEAN) X 100. WATER AND COMPOUND CONSUMPTION BY FEMALE MICE IN THE SUBCHRONIC (26-WEEK) DOSED WATER STUDY OF WATER DISINFECTION MODEL (DICHLOROACETIC ACID) ================================================================================================================================== 0 MG/L 500 MG/L 1000MG/L 2000MG/L ---------------- --------------------------------- --------------------------------- --------------------------------- DOSE/ DOSE/ DOSE/ GRAMS BODY GRAMS BODY CONTROL GRAMS BODY CONTROL GRAMS BODY CONTROL WATER/ WEIGHT WATER/ WEIGHT WATER (B) DOSE/ WATER/ WEIGHT WATER (B) DOSE/ WATER/ WEIGHT WATER (B) DOSE/ WEEK DAY(A) (GRAMS) DAY(A) (GRAMS) (GRAMS) DAY(C) DAY(A) (GRAMS) (GRAMS) DAY(C) DAY(A) (GRAMS) (GRAMS) DAY(C) ================================================================================================================================== 2 3.9 19.5 3.8 19.6 0.97 96 3.6 19.5 0.92 185 2.6 18.5 0.67 277 3 4.0 19.9 3.9 20.1 0.98 96 3.3 19.7 0.83 166 2.3 18.7 0.58 246 4 3.9 20.9 4.0 20.6 1.03 97 3.4 20.3 0.87 169 2.4 19.6 0.62 247 5 4.1 21.5 4.4 21.3 1.07 103 3.3 20.9 0.80 160 2.5 20.3 0.61 245 6 4.2 21.7 4.0 21.4 0.95 95 3.4 20.9 0.81 164 2.5 20.7 0.60 244 7 4.0 21.9 3.7 21.7 0.93 85 3.4 21.5 0.85 156 2.4 21.3 0.60 230 8 4.1 23.0 4.1 22.6 1.00 90 3.3 22.3 0.80 146 2.5 22.0 0.61 224 9 3.9 23.3 3.9 22.9 1.00 86 3.0 21.3 0.77 141 2.4 21.8 0.62 216 10 4.2 23.2 3.6 22.3 0.86 81 3.6 22.2 0.86 162 2.7 22.4 0.64 237 11 3.9 23.7 3.9 23.1 1.00 84 3.2 22.5 0.82 141 2.6 22.2 0.67 230 12 4.1 24.5 4.0 23.9 0.98 84 3.2 22.9 0.78 140 2.5 22.8 0.61 218 13 4.1 24.3 3.9 23.9 0.95 82 3.1 22.8 0.76 137 2.3 22.7 0.56 204 14 4.3 24.7 4.5 24.5 1.05 91 3.4 23.3 0.79 146 2.3 22.8 0.53 202 15 4.1 25.3 3.9 24.7 0.95 79 3.3 23.6 0.80 142 2.5 23.4 0.61 216 16 4.6 25.5 4.3 24.6 0.93 87 3.2 23.7 0.70 134 2.7 23.4 0.59 233 17 3.8 24.6 3.7 24.8 0.97 74 3.0 23.2 0.79 128 2.7 22.6 0.71 242 18 4.6 26.8 3.7 25.3 0.80 74 3.4 24.1 0.74 141 2.4 23.7 0.52 204 19 4.2 27.0 3.8 26.3 0.90 73 3.2 24.3 0.76 131 2.4 23.8 0.57 198 20 4.5 27.4 3.7 26.4 0.82 69 3.2 24.3 0.71 133 2.6 24.3 0.58 213 21 4.7 28.1 3.8 27.5 0.81 68 3.2 24.6 0.68 130 2.4 24.5 0.51 196 22 4.5 28.1 3.8 27.3 0.84 70 3.3 24.6 0.73 133 2.5 24.4 0.56 201 23 4.3 29.1 3.8 27.6 0.88 68 3.0 24.5 0.70 121 2.5 24.4 0.58 203 24 4.0 29.2 4.1 27.9 1.03 73 3.2 24.6 0.80 129 2.4 24.7 0.60 195 25 4.2 30.0 3.9 28.5 0.93 68 3.0 24.9 0.71 122 2.4 24.7 0.57 198 1 TO 13 WEEKS ---------------- MEAN 4.0 22.3 3.9 21.9 0.98 90 3.3 21.4 0.82 155 2.5 21.1 0.61 235 SD(D) 0.1 0.2 0.05 7 0.2 0.05 15 0.1 0.03 19 CV(E) 3.1 5.0 5.5 7.9 5.6 5.7 9.6 4.3 5.2 8.1 14 TO 52 WEEKS ---------------- MEAN 4.3 27.2 3.9 26.3 0.91 75 3.2 24.1 0.74 133 2.5 23.9 0.58 208 SD(D) 0.3 0.2 0.08 7 0.1 0.04 7 0.1 0.05 15 CV(E) 6.4 6.2 8.9 10.0 4.6 6.0 5.6 5.4 8.9 7.2 ================================================================================================================================== (A) GRAMS OF WATER CONSUMED PER ANIMAL PER DAY. (B) GRAMS OF WATER PER DAY FOR THE DOSED GROUP DIVIDED BY THAT FOR THE CONTROLS. (C) MILLIGRAMS OF COMPOUND CONSUMED PER DAY PER KILOGRAM BODY WEIGHT. (D) STANDARD DEVIATION OF WEEKLY MEAN. (E) COEFFICIENT OF VARIATION = (STANDARD DEVIATION / MEAN) X 100. DIAGNOSTIC TRAILER REPORT WATER AND COMPOUND CONSUMPTION BY MALE MICE IN THE SUBCHRONIC (26-WEEK) DOSED WATER STUDY OF WATER DISINFECTION MODEL (DICHLOROACETIC ACID) ========================================================================================================= 0 MG/L 500 MG/L 1000MG/L 2000MG/L ---------------------- ---------------------- ---------------------- ---------------------- DAILY WATER BODY NUM DAILY WATER BODY NUM DAILY WATER BODY NUM DAILY WATER BODY NUM WEEK WATER HOURS WGT WGTS WATER HOURS WGT WGTS WATER HOURS WGT WGTS WATER HOURS WGT WGTS ========================================================================================================== B 23.1 15 23.1 15 22.7 15 22.9 15 1 23.1 15 23.1 15 22.7 15 22.9 15 2 3.3 2440 24.1 15 3.2 2440 24.0 15 2.8 2396 23.7 15 2.4 2440 22.8 15 3 3.0 2580 25.1 15 3.0 2430 24.8 15 2.5 2286 23.8 15 2.2 2408 23.6 15 4 3.0 2495 26.4 15 3.0 2439 26.2 15 2.7 2331 25.4 15 2.1 2485 24.3 15 5 3.1 2500 27.8 15 3.0 2373 27.6 15 2.6 2540 26.1 15 2.1 2354 25.1 15 6 3.1 2520 28.9 15 3.0 2520 28.5 15 2.6 2233 26.6 15 2.1 2425 25.5 15 7 3.1 2525 30.7 15 2.9 2515 29.8 15 2.7 2510 27.9 15 1.9 2367 25.9 15 8 3.1 2505 31.9 15 2.9 2505 30.7 15 2.6 2500 28.6 15 2.2 2505 26.5 15 9 3.1 2323 33.3 15 3.1 2353 31.7 15 2.5 2525 29.2 15 2.1 2520 27.1 15 10 3.3 2299 34.7 15 3.1 2438 33.2 15 2.6 2172 29.8 15 2.1 2510 27.4 15 11 3.2 2535 36.2 15 2.9 2270 34.0 15 2.5 2126 30.5 15 2.1 2535 27.9 15 12 3.4 2338 37.4 15 3.1 2316 35.2 15 2.5 2224 31.1 15 2.0 2176 28.4 15 13 3.3 2565 38.6 15 3.1 2394 36.2 15 2.4 2394 31.1 15 1.9 2223 28.6 15 14 3.6 2490 39.5 15 3.3 2490 37.1 15 2.5 1974 31.5 15 2.1 2490 29.2 15 15 3.5 2520 40.9 15 3.0 2347 38.4 15 2.6 2391 32.5 15 2.0 2515 29.4 15 16 3.5 2555 41.4 15 3.1 2556 38.6 15 2.5 2550 32.4 15 2.3 1866 29.5 15 17 3.8 2082 42.1 15 3.1 2294 39.8 15 2.5 1937 33.1 15 1.9 1949 29.4 15 18 3.6 2496 43.4 15 3.0 2505 40.6 15 2.5 2515 33.8 15 2.1 2338 30.5 15 19 3.6 2473 44.6 15 3.2 2341 41.7 15 2.5 2520 34.6 15 2.0 2341 31.1 15 20 3.6 2421 44.9 15 3.1 2556 42.2 15 2.5 2550 35.0 15 2.0 2385 31.5 15 21 3.6 2320 45.5 15 3.0 2490 43.2 15 2.5 2371 35.6 15 2.1 2490 31.8 15 22 3.5 2371 45.8 15 3.0 2545 43.5 15 2.4 2555 35.8 15 2.1 2550 32.2 15 23 3.7 2544 46.2 15 3.1 2422 44.0 15 2.4 2540 36.1 15 2.0 2540 32.4 15 24 3.6 2510 46.7 15 3.2 2496 44.4 15 2.5 2487 36.8 15 2.1 2501 33.1 15 25 3.7 2542 46.9 15 3.0 2555 44.6 15 2.3 2545 36.6 15 2.0 2206 32.3 15 26 3.7 2535 3.1 2534 2.4 2540 2.1 2539 MEAN BODY WGT FOR WEEKS 1 TO 13 30.6 29.6 27.4 25.8 14 TO 52 44.0 41.5 34.5 31.0 ========================================================================================================= (B) REFERS TO THE BEGINNING (INITIAL) BODY WEIGHT. DIAGNOSTIC TRAILER REPORT WATER AND COMPOUND CONSUMPTION BY FEMALE MICE IN THE SUBCHRONIC (26-WEEK) DOSED WATER STUDY OF WATER DISINFECTION MODEL (DICHLOROACETIC ACID) ========================================================================================================= 0 MG/L 500 MG/L 1000MG/L 2000MG/L ---------------------- ---------------------- ---------------------- ---------------------- DAILY WATER BODY NUM DAILY WATER BODY NUM DAILY WATER BODY NUM DAILY WATER BODY NUM WEEK WATER HOURS WGT WGTS WATER HOURS WGT WGTS WATER HOURS WGT WGTS WATER HOURS WGT WGTS ========================================================================================================== B 18.7 15 18.6 15 18.8 15 18.4 15 1 18.7 15 18.6 15 18.8 15 18.4 15 2 3.9 2440 19.5 15 3.8 2327 19.6 15 3.6 2282 19.5 15 2.6 2435 18.5 15 3 4.0 2580 19.9 15 3.9 2580 20.1 15 3.3 2580 19.7 15 2.3 2133 18.7 15 4 3.9 2485 20.9 15 4.0 2320 20.6 15 3.4 2495 20.3 15 2.4 2475 19.6 15 5 4.1 2354 21.5 15 4.4 2067 21.3 15 3.3 2389 20.9 15 2.5 2215 20.3 15 6 4.2 2520 21.7 15 4.0 2016 21.4 15 3.4 2352 20.9 15 2.5 2253 20.7 15 7 4.0 2327 21.9 15 3.7 1834 21.7 15 3.4 2342 21.5 15 2.4 2188 21.3 15 8 4.1 2500 23.0 15 4.1 2004 22.6 15 3.3 2505 22.3 15 2.5 2329 22.0 15 9 3.9 2520 23.3 15 3.9 2068 22.9 15 3.0 2021 21.3 15 2.4 2010 21.8 15 10 4.2 2510 23.2 15 3.6 1674 22.3 15 3.6 2515 22.2 15 2.7 2505 22.4 15 11 3.9 2535 23.7 15 3.9 2124 23.1 15 3.2 2485 22.5 15 2.6 2146 22.2 15 12 4.1 2264 24.5 15 4.0 2057 23.9 15 3.2 2510 22.9 15 2.5 2166 22.8 15 13 4.1 2565 24.3 15 3.9 2052 23.9 15 3.1 2565 22.8 15 2.3 2394 22.7 15 14 4.3 2490 24.7 15 4.5 1992 24.5 15 3.4 2490 23.3 15 2.3 2135 22.8 15 15 4.1 2348 25.3 15 3.9 2343 24.7 15 3.3 2515 23.6 15 2.5 2394 23.4 15 16 4.6 2550 25.5 15 4.3 2217 24.6 15 3.2 2380 23.7 15 2.7 2197 23.4 15 17 3.8 1744 24.6 15 3.7 1912 24.8 15 3.0 1719 23.2 15 2.7 1577 22.6 15 18 4.6 2171 26.8 15 3.7 2056 25.3 15 3.4 2500 24.1 15 2.4 2510 23.7 15 19 4.2 2314 27.0 15 3.8 1964 26.3 15 3.2 2343 24.3 15 2.4 2406 23.8 15 20 4.5 2343 27.4 15 3.7 1996 26.4 15 3.2 2565 24.3 15 2.6 2558 24.3 15 21 4.7 2325 28.1 15 3.8 1985 27.5 15 3.2 2315 24.6 15 2.4 2399 24.5 15 22 4.5 2185 28.1 15 3.8 1746 27.3 15 3.3 2371 24.6 15 2.5 2555 24.4 15 23 4.3 2244 29.1 15 3.8 1746 27.6 15 3.0 2380 24.5 15 2.5 2535 24.4 15 24 4.0 2495 29.2 15 4.1 1987 27.9 15 3.2 2501 24.6 15 2.4 2496 24.7 15 25 4.2 2376 30.0 15 3.9 1754 28.5 15 3.0 2237 24.9 14 2.4 2375 24.7 14 26 4.1 2535 3.8 2192 2.8 2357 2.4 2372 MEAN BODY WGT FOR WEEKS 1 TO 13 22.0 21.7 21.2 20.9 14 TO 52 27.2 26.3 24.1 23.9 ========================================================================================================= (B) REFERS TO THE BEGINNING (INITIAL) BODY WEIGHT.