TDMS Study 97013-14 Pathology Tables
NTP Experiment-Test: 97013-14 INCIDENCE RATES OF NONNEOPLASTIC LESIONS BY ANATOMIC SITE (a) Report: PEIRPT03
Study Type: SUBCHRON 26-WEEK WATER DISINFECTION MODEL (DICHLOROACETIC ACID) Date: 01/27/05
Route: DOSED WATER Time: 10:24:14
FINAL #1 P53 MICE
Facility: Battelle Columbus Laboratory
Chemical CAS #: 79-43-6
Lock Date: 07/31/01
Cage Range: All
Reasons For Removal: 25019 Moribund Sacrifice 25020 Natural Death
25021 Terminal Sacrifice
Removal Date Range: All
Treatment Groups: Include All
a Number of animals examined microscopically at site and number of animals with lesion
Page 1
NTP Experiment-Test: 97013-14 INCIDENCE RATES OF NONNEOPLASTIC LESIONS BY ANATOMIC SITE (a) Report: PEIRPT03
Study Type: SUBCHRON 26-WEEK WATER DISINFECTION MODEL (DICHLOROACETIC ACID) Date: 01/27/05
Route: DOSED WATER Time: 10:24:14
____________________________________________________________________________________________________________________________________
P53+/-(C57BL/6) FEMALE 0 MG/L 500 MG/L 1000MG/L 2000MG/L
____________________________________________________________________________________________________________________________________
DISPOSITION SUMMARY
Animals Initially In Study 15 15 15 15
Early Deaths
Natural Death 1
Moribund Sacrifice 1
Survivors
Terminal Sacrifice 15 15 14 14
Animals Examined Microscopically 15 15 15 15
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ALIMENTARY SYSTEM
Liver (15) (15) (15) (15)
Inflammation, Chronic Active 15 (100%) 14 (93%) 13 (87%) 14 (93%)
Hepatocyte, Necrosis 1 (7%)
Hepatocyte, Vacuolization Cytoplasmic 3 (20%) 15 (100%) 15 (100%) 15 (100%)
Stomach, Forestomach (15) (15) (15) (15)
Inflammation, Chronic Active 1 (7%)
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CARDIOVASCULAR SYSTEM
None
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ENDOCRINE SYSTEM
Adrenal Cortex (15) (15) (15) (15)
Accessory Adrenal Cortical Nodule 4 (27%) 2 (13%) 1 (7%)
Subcapsular, Hyperplasia 14 (93%) 14 (93%) 15 (100%) 14 (93%)
Parathyroid Gland (1)
Cyst 1 (100%)
Pituitary Gland (15) (15) (15) (15)
Pars Distalis, Cyst 1 (7%) 2 (13%) 3 (20%)
Pars Distalis, Hyperplasia 1 (7%) 3 (20%) 5 (33%)
Thyroid Gland (15) (15) (15) (15)
Ectopic Thymus 1 (7%)
Infiltration Cellular, Lymphocyte 2 (13%) 1 (7%)
Follicle, Degeneration 1 (7%) 3 (20%)
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GENERAL BODY SYSTEM
a Number of animals examined microscopically at site and number of animals with lesion
Page 2
NTP Experiment-Test: 97013-14 INCIDENCE RATES OF NONNEOPLASTIC LESIONS BY ANATOMIC SITE (a) Report: PEIRPT03
Study Type: SUBCHRON 26-WEEK WATER DISINFECTION MODEL (DICHLOROACETIC ACID) Date: 01/27/05
Route: DOSED WATER Time: 10:24:14
____________________________________________________________________________________________________________________________________
P53+/-(C57BL/6) FEMALE 0 MG/L 500 MG/L 1000MG/L 2000MG/L
____________________________________________________________________________________________________________________________________
None
____________________________________________________________________________________________________________________________________
GENITAL SYSTEM
Ovary (15) (15) (15) (15)
Cyst 2 (13%) 1 (7%) 1 (7%)
Uterus (15) (15) (15) (15)
Inflammation, Chronic Active 1 (7%) 1 (7%)
Endometrium, Hyperplasia, Cystic 8 (53%) 12 (80%) 13 (87%) 13 (87%)
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HEMATOPOIETIC SYSTEM
Lymph Node (1)
Mediastinal, Hyperplasia, Lymphoid 1 (100%)
Lymph Node, Mandibular (15) (15) (15) (15)
Hyperplasia, Lymphoid 1 (7%) 4 (27%) 4 (27%)
Lymph Node, Mesenteric (15) (15) (15) (15)
Hyperplasia, Lymphoid 1 (7%)
Spleen (15) (15) (15) (15)
Atrophy 1 (7%)
Thymus (15) (15) (15) (15)
Atrophy 1 (7%)
Cyst 10 (67%) 11 (73%) 11 (73%) 12 (80%)
Ectopic Parathyroid Gland 2 (13%) 2 (13%) 1 (7%) 2 (13%)
Thymocyte, Necrosis 6 (40%) 2 (13%) 1 (7%)
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INTEGUMENTARY SYSTEM
None
____________________________________________________________________________________________________________________________________
MUSCULOSKELETAL SYSTEM
None
____________________________________________________________________________________________________________________________________
NERVOUS SYSTEM
None
____________________________________________________________________________________________________________________________________
a Number of animals examined microscopically at site and number of animals with lesion
Page 3
NTP Experiment-Test: 97013-14 INCIDENCE RATES OF NONNEOPLASTIC LESIONS BY ANATOMIC SITE (a) Report: PEIRPT03
Study Type: SUBCHRON 26-WEEK WATER DISINFECTION MODEL (DICHLOROACETIC ACID) Date: 01/27/05
Route: DOSED WATER Time: 10:24:14
____________________________________________________________________________________________________________________________________
P53+/-(C57BL/6) FEMALE 0 MG/L 500 MG/L 1000MG/L 2000MG/L
____________________________________________________________________________________________________________________________________
RESPIRATORY SYSTEM
Lung (15) (15) (15) (15)
Inflammation, Chronic Active 2 (13%) 3 (20%) 1 (7%)
Alveolus, Infiltration Cellular, Histiocyte 1 (7%)
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SPECIAL SENSES SYSTEM
None
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URINARY SYSTEM
Kidney (15) (15) (15) (15)
Cyst 1 (7%)
Mineralization 4 (27%) 1 (7%)
Nephropathy 3 (20%) 11 (73%) 7 (47%) 9 (60%)
Renal Tubule, Dilatation 2 (13%) 1 (7%)
a Number of animals examined microscopically at site and number of animals with lesion
Page 4
NTP Experiment-Test: 97013-14 INCIDENCE RATES OF NONNEOPLASTIC LESIONS BY ANATOMIC SITE (a) Report: PEIRPT03
Study Type: SUBCHRON 26-WEEK WATER DISINFECTION MODEL (DICHLOROACETIC ACID) Date: 01/27/05
Route: DOSED WATER Time: 10:24:14
____________________________________________________________________________________________________________________________________
P53+/-(C57BL/6) MALE 0 MG/L 500 MG/L 1000MG/L 2000MG/L
____________________________________________________________________________________________________________________________________
DISPOSITION SUMMARY
Animals Initially In Study 15 15 15 15
Early Deaths
Survivors
Terminal Sacrifice 15 15 15 15
Animals Examined Microscopically 15 15 15 15
____________________________________________________________________________________________________________________________________
ALIMENTARY SYSTEM
Liver (15) (15) (15) (15)
Hematopoietic Cell Proliferation 1 (7%)
Inflammation, Chronic Active 15 (100%) 13 (87%) 15 (100%) 13 (87%)
Hepatocyte, Fatty Change 10 (67%) 2 (13%) 1 (7%)
Hepatocyte, Necrosis 1 (7%) 1 (7%)
Hepatocyte, Vacuolization Cytoplasmic 15 (100%) 15 (100%) 15 (100%) 15 (100%)
____________________________________________________________________________________________________________________________________
CARDIOVASCULAR SYSTEM
None
____________________________________________________________________________________________________________________________________
ENDOCRINE SYSTEM
Adrenal Cortex (15) (15) (15) (15)
Accessory Adrenal Cortical Nodule 1 (7%) 1 (7%)
Hypertrophy 1 (7%) 1 (7%) 2 (13%)
Subcapsular, Hyperplasia 4 (27%) 3 (20%) 3 (20%)
Pituitary Gland (15) (15) (15) (15)
Pars Distalis, Cyst 3 (20%) 2 (13%) 2 (13%) 1 (7%)
Pars Distalis, Hyperplasia 6 (40%)
Thyroid Gland (15) (15) (15) (15)
Ectopic Thymus 2 (13%)
Follicle, Cyst 1 (7%)
____________________________________________________________________________________________________________________________________
GENERAL BODY SYSTEM
None
____________________________________________________________________________________________________________________________________
a Number of animals examined microscopically at site and number of animals with lesion
Page 5
NTP Experiment-Test: 97013-14 INCIDENCE RATES OF NONNEOPLASTIC LESIONS BY ANATOMIC SITE (a) Report: PEIRPT03
Study Type: SUBCHRON 26-WEEK WATER DISINFECTION MODEL (DICHLOROACETIC ACID) Date: 01/27/05
Route: DOSED WATER Time: 10:24:14
____________________________________________________________________________________________________________________________________
P53+/-(C57BL/6) MALE 0 MG/L 500 MG/L 1000MG/L 2000MG/L
____________________________________________________________________________________________________________________________________
GENITAL SYSTEM
Epididymis (15) (15) (15) (15)
Granuloma Sperm 1 (7%)
Infiltration Cellular, Lymphocyte 3 (20%)
Inflammation, Chronic Active 1 (7%)
Testes (15) (15) (15) (15)
Mineralization 1 (7%) 1 (7%)
Germinal Epithelium, Degeneration 2 (13%) 4 (27%) 3 (20%) 1 (7%)
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HEMATOPOIETIC SYSTEM
Lymph Node, Mandibular (15) (15) (15) (15)
Hyperplasia, Lymphoid 2 (13%) 1 (7%)
Lymph Node, Mesenteric (15) (15) (15) (15)
Hyperplasia, Lymphoid 1 (7%) 1 (7%)
Thymus (15) (15) (15) (15)
Cyst 9 (60%) 9 (60%) 9 (60%) 9 (60%)
Ectopic Parathyroid Gland 1 (7%)
Hyperplasia, Lymphoid 1 (7%)
____________________________________________________________________________________________________________________________________
INTEGUMENTARY SYSTEM
None
____________________________________________________________________________________________________________________________________
MUSCULOSKELETAL SYSTEM
None
____________________________________________________________________________________________________________________________________
NERVOUS SYSTEM
None
____________________________________________________________________________________________________________________________________
RESPIRATORY SYSTEM
None
____________________________________________________________________________________________________________________________________
SPECIAL SENSES SYSTEM
a Number of animals examined microscopically at site and number of animals with lesion
Page 6
NTP Experiment-Test: 97013-14 INCIDENCE RATES OF NONNEOPLASTIC LESIONS BY ANATOMIC SITE (a) Report: PEIRPT03
Study Type: SUBCHRON 26-WEEK WATER DISINFECTION MODEL (DICHLOROACETIC ACID) Date: 01/27/05
Route: DOSED WATER Time: 10:24:14
____________________________________________________________________________________________________________________________________
P53+/-(C57BL/6) MALE 0 MG/L 500 MG/L 1000MG/L 2000MG/L
____________________________________________________________________________________________________________________________________
None
____________________________________________________________________________________________________________________________________
URINARY SYSTEM
Kidney (15) (15) (15) (15)
Mineralization 1 (7%)
Nephropathy 8 (53%) 10 (67%) 11 (73%) 12 (80%)
Renal Tubule, Dilatation 2 (13%) 4 (27%) 2 (13%)
a Number of animals examined microscopically at site and number of animals with lesion
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