TDMS Study 97013-14 Pathology Tables

NTP Experiment-Test: 97013-14  INCIDENCE RATES OF NEOPLASMS BY ANATOMIC SITE (SYSTEMIC LESIONS ABRIDGED) (a)      Report: PEIRPT05
Study Type: SUBCHRON 26-WEEK                  WATER DISINFECTION MODEL (DICHLOROACETIC ACID)                      Date: 01/27/05
Route: DOSED WATER                                                                                                Time: 09:29:24
                                                          FINAL #1/P53
       Facility:  Battelle Columbus Laboratory
       Chemical CAS #:  79-43-6
       Lock Date:  07/31/01
       Cage Range:  All
       Reasons For Removal:    25019 Moribund Sacrifice                25020 Natural Death
                               25021 Terminal Sacrifice
       Removal Date Range:     All
       Treatment Groups:       Include All
a  Number of animals examined microscopically at site and number of animals with lesion
                                                              Page   1
NTP Experiment-Test: 97013-14  INCIDENCE RATES OF NEOPLASMS BY ANATOMIC SITE (SYSTEMIC LESIONS ABRIDGED) (a)      Report: PEIRPT05
Study Type: SUBCHRON 26-WEEK                  WATER DISINFECTION MODEL (DICHLOROACETIC ACID)                      Date: 01/27/05  
Route: DOSED WATER                                                                                                Time: 09:29:24  
____________________________________________________________________________________________________________________________________
         P53+/-(C57BL/6) FEMALE                    0 MG/L       500 MG/L     1000MG/L     2000MG/L                                  
____________________________________________________________________________________________________________________________________
DISPOSITION SUMMARY                                                                                                                 
  Animals Initially in Study                          15           15           15           15                                     
  Early Deaths                                                                                                                      
    Natural Death                                                                1                                                  
    Moribund Sacrifice                                                                        1                                     
  Survivors                                                                                                                         
    Terminal Sacrifice                                15           15           14           14                                     
  Animals Examined Microscopically                    15           15           15           15                                     
____________________________________________________________________________________________________________________________________
 ALIMENTARY SYSTEM                                                                                                                  
   Intestine Large, Cecum                             (15)         (15)         (15)         (15)                                   
   Liver                                              (15)         (15)         (15)         (15)                                   
   Mesentery                                                                                 (1)                                    
____________________________________________________________________________________________________________________________________
 CARDIOVASCULAR SYSTEM                                                                                                              
   None                                                                                                                             
____________________________________________________________________________________________________________________________________
 ENDOCRINE SYSTEM                                                                                                                   
   Pituitary Gland                                    (15)         (15)         (15)         (15)                                   
      Pars Distalis, Adenoma                                        1 (7%)                                                          
____________________________________________________________________________________________________________________________________
 GENERAL BODY SYSTEM                                                                                                                
   None                                                                                                                             
____________________________________________________________________________________________________________________________________
 GENITAL SYSTEM                                                                                                                     
   Ovary                                              (15)         (15)         (15)         (15)                                   
   Uterus                                             (15)         (15)         (15)         (15)                                   
      Polyp Stromal                                    1 (7%)                                                                       
____________________________________________________________________________________________________________________________________
                                                             Page   2                                                               
NTP Experiment-Test: 97013-14  INCIDENCE RATES OF NEOPLASMS BY ANATOMIC SITE (SYSTEMIC LESIONS ABRIDGED) (a)      Report: PEIRPT05
Study Type: SUBCHRON 26-WEEK                  WATER DISINFECTION MODEL (DICHLOROACETIC ACID)                      Date: 01/27/05  
Route: DOSED WATER                                                                                                Time: 09:29:24  
____________________________________________________________________________________________________________________________________
         P53+/-(C57BL/6) FEMALE                    0 MG/L       500 MG/L     1000MG/L     2000MG/L                                  
____________________________________________________________________________________________________________________________________
 HEMATOPOIETIC SYSTEM                                                                                                               
   Lymph Node, Mesenteric                             (15)         (15)         (15)         (15)                                   
   Thymus                                             (15)         (15)         (15)         (15)                                   
____________________________________________________________________________________________________________________________________
 INTEGUMENTARY SYSTEM                                                                                                               
   None                                                                                                                             
____________________________________________________________________________________________________________________________________
 MUSCULOSKELETAL SYSTEM                                                                                                             
   None                                                                                                                             
____________________________________________________________________________________________________________________________________
 NERVOUS SYSTEM                                                                                                                     
   None                                                                                                                             
____________________________________________________________________________________________________________________________________
 RESPIRATORY SYSTEM                                                                                                                 
   Lung                                               (15)         (15)         (15)         (15)                                   
____________________________________________________________________________________________________________________________________
 SPECIAL SENSES SYSTEM                                                                                                              
   None                                                                                                                             
____________________________________________________________________________________________________________________________________
 URINARY SYSTEM                                                                                                                     
   None                                                                                                                             
____________________________________________________________________________________________________________________________________
 SYSTEMIC LESIONS                                                                                                                   
   Multiple Organs                                   *(15)        *(15)        *(15)        *(15)                                   
      Lymphoma Malignant                                                         1 (7%)       1 (7%)                                
____________________________________________________________________________________________________________________________________
     *   Number of animals with any tissue examined microscopically                                                                 
                                                             Page   3                                                               
NTP Experiment-Test: 97013-14  INCIDENCE RATES OF NEOPLASMS BY ANATOMIC SITE (SYSTEMIC LESIONS ABRIDGED) (a)      Report: PEIRPT05
Study Type: SUBCHRON 26-WEEK                  WATER DISINFECTION MODEL (DICHLOROACETIC ACID)                      Date: 01/27/05  
Route: DOSED WATER                                                                                                Time: 09:29:24  
____________________________________________________________________________________________________________________________________
         P53+/-(C57BL/6) FEMALE                    0 MG/L       500 MG/L     1000MG/L     2000MG/L                                  
____________________________________________________________________________________________________________________________________
TUMOR SUMMARY                                                                                                                       
   Total Animals with Primary Neoplasms (b)             1           1           1           1                                       
     Total Primary Neoplasms                            1           1           1           1                                       
   Total Animals with Benign Neoplasms                  1           1                                                               
     Total Benign Neoplasms                             1           1                                                               
   Total Animals with Malignant Neoplasms                                       1           1                                       
     Total Malignant Neoplasms                                                  1           1                                       
   Total Animals with Metastatic Neoplasms                                                                                          
     Total Metastatic Neoplasm                                                                                                      
   Total Animals with Malignant Neoplasms                                                                                           
   Uncertain Primary Site                                                                                                           
   Total Animals with Neoplasms Uncertain-                                                                                          
   Benign or Malignant                                                                                                              
     Total Uncertain Neoplasms                                                                                                      
____________________________________________________________________________________________________________________________________
a  Number of animals examined microscopically at site and number of animals with lesion                                             
b  Primary tumors: all tumors except metastatic tumors                                                                              
                                                             Page   4                                                               
NTP Experiment-Test: 97013-14  INCIDENCE RATES OF NEOPLASMS BY ANATOMIC SITE (SYSTEMIC LESIONS ABRIDGED) (a)      Report: PEIRPT05
Study Type: SUBCHRON 26-WEEK                  WATER DISINFECTION MODEL (DICHLOROACETIC ACID)                      Date: 01/27/05  
Route: DOSED WATER                                                                                                Time: 09:29:24  
____________________________________________________________________________________________________________________________________
         P53+/-(C57BL/6) MALE                      0 MG/L       500 MG/L     1000MG/L     2000MG/L                                  
____________________________________________________________________________________________________________________________________
DISPOSITION SUMMARY                                                                                                                 
  Animals Initially in Study                          15           15           15           15                                     
  Early Deaths                                                                                                                      
  Survivors                                                                                                                         
    Terminal Sacrifice                                15           15           15           15                                     
  Animals Examined Microscopically                    15           15           15           15                                     
____________________________________________________________________________________________________________________________________
 ALIMENTARY SYSTEM                                                                                                                  
   None                                                                                                                             
____________________________________________________________________________________________________________________________________
 CARDIOVASCULAR SYSTEM                                                                                                              
   None                                                                                                                             
____________________________________________________________________________________________________________________________________
 ENDOCRINE SYSTEM                                                                                                                   
   None                                                                                                                             
____________________________________________________________________________________________________________________________________
 GENERAL BODY SYSTEM                                                                                                                
   None                                                                                                                             
____________________________________________________________________________________________________________________________________
 GENITAL SYSTEM                                                                                                                     
   None                                                                                                                             
____________________________________________________________________________________________________________________________________
 HEMATOPOIETIC SYSTEM                                                                                                               
   None                                                                                                                             
____________________________________________________________________________________________________________________________________
                                                             Page   5                                                               
NTP Experiment-Test: 97013-14  INCIDENCE RATES OF NEOPLASMS BY ANATOMIC SITE (SYSTEMIC LESIONS ABRIDGED) (a)      Report: PEIRPT05
Study Type: SUBCHRON 26-WEEK                  WATER DISINFECTION MODEL (DICHLOROACETIC ACID)                      Date: 01/27/05  
Route: DOSED WATER                                                                                                Time: 09:29:24  
____________________________________________________________________________________________________________________________________
         P53+/-(C57BL/6) MALE                      0 MG/L       500 MG/L     1000MG/L     2000MG/L                                  
____________________________________________________________________________________________________________________________________
 INTEGUMENTARY SYSTEM                                                                                                               
   None                                                                                                                             
____________________________________________________________________________________________________________________________________
 MUSCULOSKELETAL SYSTEM                                                                                                             
   None                                                                                                                             
____________________________________________________________________________________________________________________________________
 NERVOUS SYSTEM                                                                                                                     
   None                                                                                                                             
____________________________________________________________________________________________________________________________________
 RESPIRATORY SYSTEM                                                                                                                 
   None                                                                                                                             
____________________________________________________________________________________________________________________________________
 SPECIAL SENSES SYSTEM                                                                                                              
   None                                                                                                                             
____________________________________________________________________________________________________________________________________
 URINARY SYSTEM                                                                                                                     
   None                                                                                                                             
                                                             Page   6                                                               
                             ------------------------------------------------------------                                           
                             ----------              END OF REPORT             ----------                                           
                             ------------------------------------------------------------