TDMS Study 97013-14 Pathology Tables
NTP Experiment-Test: 97013-14 INCIDENCE RATES OF NONNEOPLASTIC LESIONS BY ANATOMIC SITE (a) Report: PEIRPT18 Study Type: SUBCHRON 26-WEEK WITH AVERAGE SEVERITY GRADES[b] Date: 01/27/05 Route: DOSED WATER WATER DISINFECTION MODEL (DICHLOROACETIC ACID) Time: 09:31:44 FINAL #1/P53 Facility: Battelle Columbus Laboratory Chemical CAS #: 79-43-6 Lock Date: 07/31/01 Cage Range: All Reasons For Removal: 25019 Moribund Sacrifice 25020 Natural Death 25021 Terminal Sacrifice Removal Date Range: All Treatment Groups: Include All a Number of animals examined microscopically at site and number of animals with lesion b Average severity grade (1-minimal;2-mild;3-moderate;4-marked) Page 1 NTP Experiment-Test: 97013-14 INCIDENCE RATES OF NONNEOPLASTIC LESIONS BY ANATOMIC SITE (a) Report: PEIRPT18 Study Type: SUBCHRON 26-WEEK WITH AVERAGE SEVERITY GRADES[b] Date: 01/27/05 Route: DOSED WATER WATER DISINFECTION MODEL (DICHLOROACETIC ACID) Time: 09:31:44 ____________________________________________________________________________________________________________________________________ P53+/-(C57BL/6) FEMALE 0 MG/L 500 MG/L 1000MG/L 2000MG/L ____________________________________________________________________________________________________________________________________ DISPOSITION SUMMARY Animals Initially In Study 15 15 15 15 Early Deaths Natural Death 1 Moribund Sacrifice 1 Survivors Terminal Sacrifice 15 15 14 14 Animals Examined Microscopically 15 15 15 15 ____________________________________________________________________________________________________________________________________ ALIMENTARY SYSTEM Liver (15) (15) (15) (15) Inflammation, Chronic Active 15 [1.2] 14 [1.1] 13 [1.2] 14 [1.1] Hepatocyte, Necrosis 1 [1.0] Hepatocyte, Vacuolization Cytoplasmic 3 [1.0] 15 [2.2] 15 [3.1] 15 [3.5] Stomach, Forestomach (15) (15) (15) (15) Inflammation, Chronic Active 1 [1.0] ____________________________________________________________________________________________________________________________________ CARDIOVASCULAR SYSTEM None ____________________________________________________________________________________________________________________________________ ENDOCRINE SYSTEM Adrenal Cortex (15) (15) (15) (15) Accessory Adrenal Cortical Nodule 4 [1.5] 2 [2.0] 1 [1.0] Subcapsular, Hyperplasia 14 [1.0] 14 [1.0] 15 [1.0] 14 [1.1] Parathyroid Gland (1) Cyst 1 [2.0] Pituitary Gland (15) (15) (15) (15) Pars Distalis, Cyst 1 [1.0] 2 [1.0] 3 [1.0] Pars Distalis, Hyperplasia 1 [1.0] 3 [1.0] 5 [1.0] Thyroid Gland (15) (15) (15) (15) Ectopic Thymus 1 [2.0] Infiltration Cellular, Lymphocyte 2 [2.0] 1 [2.0] Follicle, Degeneration 1 [1.0] 3 [1.0] ____________________________________________________________________________________________________________________________________ GENERAL BODY SYSTEM a Number of animals examined microscopically at site and number of animals with lesion b Average severity grade (1-minimal;2-mild;3-moderate;4-marked) Page 2 NTP Experiment-Test: 97013-14 INCIDENCE RATES OF NONNEOPLASTIC LESIONS BY ANATOMIC SITE (a) Report: PEIRPT18 Study Type: SUBCHRON 26-WEEK WITH AVERAGE SEVERITY GRADES[b] Date: 01/27/05 Route: DOSED WATER WATER DISINFECTION MODEL (DICHLOROACETIC ACID) Time: 09:31:44 ____________________________________________________________________________________________________________________________________ P53+/-(C57BL/6) FEMALE 0 MG/L 500 MG/L 1000MG/L 2000MG/L ____________________________________________________________________________________________________________________________________ None ____________________________________________________________________________________________________________________________________ GENITAL SYSTEM Ovary (15) (15) (15) (15) Cyst 2 [2.5] 1 [2.0] 1 [2.0] Uterus (15) (15) (15) (15) Inflammation, Chronic Active 1 [3.0] 1 [1.0] Endometrium, Hyperplasia, Cystic 8 [1.5] 12 [1.9] 13 [1.6] 13 [1.4] ____________________________________________________________________________________________________________________________________ HEMATOPOIETIC SYSTEM Lymph Node (1) Mediastinal, Hyperplasia, Lymphoid 1 [3.0] Lymph Node, Mandibular (15) (15) (15) (15) Hyperplasia, Lymphoid 1 [2.0] 4 [2.3] 4 [2.5] Lymph Node, Mesenteric (15) (15) (15) (15) Hyperplasia, Lymphoid 1 [2.0] Spleen (15) (15) (15) (15) Atrophy 1 [2.0] Thymus (15) (15) (15) (15) Atrophy 1 [3.0] Cyst 10 [1.6] 11 [1.8] 11 [1.6] 12 [1.7] Ectopic Parathyroid Gland 2 [1.5] 2 [1.0] 1 [1.0] 2 [1.0] Thymocyte, Necrosis 6 [1.8] 2 [2.0] 1 [2.0] ____________________________________________________________________________________________________________________________________ INTEGUMENTARY SYSTEM None ____________________________________________________________________________________________________________________________________ MUSCULOSKELETAL SYSTEM None ____________________________________________________________________________________________________________________________________ NERVOUS SYSTEM None ____________________________________________________________________________________________________________________________________ a Number of animals examined microscopically at site and number of animals with lesion b Average severity grade (1-minimal;2-mild;3-moderate;4-marked) Page 3 NTP Experiment-Test: 97013-14 INCIDENCE RATES OF NONNEOPLASTIC LESIONS BY ANATOMIC SITE (a) Report: PEIRPT18 Study Type: SUBCHRON 26-WEEK WITH AVERAGE SEVERITY GRADES[b] Date: 01/27/05 Route: DOSED WATER WATER DISINFECTION MODEL (DICHLOROACETIC ACID) Time: 09:31:44 ____________________________________________________________________________________________________________________________________ P53+/-(C57BL/6) FEMALE 0 MG/L 500 MG/L 1000MG/L 2000MG/L ____________________________________________________________________________________________________________________________________ RESPIRATORY SYSTEM Lung (15) (15) (15) (15) Inflammation, Chronic Active 2 [1.5] 3 [1.0] 1 [2.0] Alveolus, Infiltration Cellular, Histiocyte 1 [3.0] ____________________________________________________________________________________________________________________________________ SPECIAL SENSES SYSTEM None ____________________________________________________________________________________________________________________________________ URINARY SYSTEM Kidney (15) (15) (15) (15) Cyst 1 [3.0] Mineralization 4 [1.0] 1 [1.0] Nephropathy 3 [1.0] 11 [1.0] 7 [1.0] 9 [1.0] Renal Tubule, Dilatation 2 [2.0] 1 [2.0] a Number of animals examined microscopically at site and number of animals with lesion b Average severity grade (1-minimal;2-mild;3-moderate;4-marked) Page 4 NTP Experiment-Test: 97013-14 INCIDENCE RATES OF NONNEOPLASTIC LESIONS BY ANATOMIC SITE (a) Report: PEIRPT18 Study Type: SUBCHRON 26-WEEK WITH AVERAGE SEVERITY GRADES[b] Date: 01/27/05 Route: DOSED WATER WATER DISINFECTION MODEL (DICHLOROACETIC ACID) Time: 09:31:44 ____________________________________________________________________________________________________________________________________ P53+/-(C57BL/6) MALE 0 MG/L 500 MG/L 1000MG/L 2000MG/L ____________________________________________________________________________________________________________________________________ DISPOSITION SUMMARY Animals Initially In Study 15 15 15 15 Early Deaths Survivors Terminal Sacrifice 15 15 15 15 Animals Examined Microscopically 15 15 15 15 ____________________________________________________________________________________________________________________________________ ALIMENTARY SYSTEM Liver (15) (15) (15) (15) Hematopoietic Cell Proliferation 1 [1.0] Inflammation, Chronic Active 15 [1.0] 13 [1.0] 15 [1.1] 13 [1.0] Hepatocyte, Fatty Change 10 [1.1] 2 [1.0] 1 [1.0] Hepatocyte, Necrosis 1 [1.0] 1 [1.0] Hepatocyte, Vacuolization Cytoplasmic 15 [2.7] 15 [3.4] 15 [3.4] 15 [4.0] ____________________________________________________________________________________________________________________________________ CARDIOVASCULAR SYSTEM None ____________________________________________________________________________________________________________________________________ ENDOCRINE SYSTEM Adrenal Cortex (15) (15) (15) (15) Accessory Adrenal Cortical Nodule 1 [1.0] 1 [2.0] Hypertrophy 1 [2.0] 1 [2.0] 2 [1.5] Subcapsular, Hyperplasia 4 [1.0] 3 [1.0] 3 [1.0] Pituitary Gland (15) (15) (15) (15) Pars Distalis, Cyst 3 [1.0] 2 [1.0] 2 [1.0] 1 [1.0] Pars Distalis, Hyperplasia 6 [1.0] Thyroid Gland (15) (15) (15) (15) Ectopic Thymus 2 [1.5] Follicle, Cyst 1 [2.0] ____________________________________________________________________________________________________________________________________ GENERAL BODY SYSTEM None ____________________________________________________________________________________________________________________________________ a Number of animals examined microscopically at site and number of animals with lesion b Average severity grade (1-minimal;2-mild;3-moderate;4-marked) Page 5 NTP Experiment-Test: 97013-14 INCIDENCE RATES OF NONNEOPLASTIC LESIONS BY ANATOMIC SITE (a) Report: PEIRPT18 Study Type: SUBCHRON 26-WEEK WITH AVERAGE SEVERITY GRADES[b] Date: 01/27/05 Route: DOSED WATER WATER DISINFECTION MODEL (DICHLOROACETIC ACID) Time: 09:31:44 ____________________________________________________________________________________________________________________________________ P53+/-(C57BL/6) MALE 0 MG/L 500 MG/L 1000MG/L 2000MG/L ____________________________________________________________________________________________________________________________________ GENITAL SYSTEM Epididymis (15) (15) (15) (15) Granuloma Sperm 1 [3.0] Infiltration Cellular, Lymphocyte 3 [1.3] Inflammation, Chronic Active 1 [1.0] Testes (15) (15) (15) (15) Mineralization 1 [1.0] 1 [1.0] Germinal Epithelium, Degeneration 2 [1.0] 4 [1.0] 3 [1.0] 1 [1.0] ____________________________________________________________________________________________________________________________________ HEMATOPOIETIC SYSTEM Lymph Node, Mandibular (15) (15) (15) (15) Hyperplasia, Lymphoid 2 [2.0] 1 [2.0] Lymph Node, Mesenteric (15) (15) (15) (15) Hyperplasia, Lymphoid 1 [2.0] 1 [2.0] Thymus (15) (15) (15) (15) Cyst 9 [1.4] 9 [1.9] 9 [1.4] 9 [1.3] Ectopic Parathyroid Gland 1 [1.0] Hyperplasia, Lymphoid 1 [2.0] ____________________________________________________________________________________________________________________________________ INTEGUMENTARY SYSTEM None ____________________________________________________________________________________________________________________________________ MUSCULOSKELETAL SYSTEM None ____________________________________________________________________________________________________________________________________ NERVOUS SYSTEM None ____________________________________________________________________________________________________________________________________ RESPIRATORY SYSTEM None ____________________________________________________________________________________________________________________________________ SPECIAL SENSES SYSTEM a Number of animals examined microscopically at site and number of animals with lesion b Average severity grade (1-minimal;2-mild;3-moderate;4-marked) Page 6 NTP Experiment-Test: 97013-14 INCIDENCE RATES OF NONNEOPLASTIC LESIONS BY ANATOMIC SITE (a) Report: PEIRPT18 Study Type: SUBCHRON 26-WEEK WITH AVERAGE SEVERITY GRADES[b] Date: 01/27/05 Route: DOSED WATER WATER DISINFECTION MODEL (DICHLOROACETIC ACID) Time: 09:31:44 ____________________________________________________________________________________________________________________________________ P53+/-(C57BL/6) MALE 0 MG/L 500 MG/L 1000MG/L 2000MG/L ____________________________________________________________________________________________________________________________________ None ____________________________________________________________________________________________________________________________________ URINARY SYSTEM Kidney (15) (15) (15) (15) Mineralization 1 [1.0] Nephropathy 8 [1.0] 10 [1.0] 11 [1.0] 12 [1.0] Renal Tubule, Dilatation 2 [1.5] 4 [1.8] 2 [1.5] a Number of animals examined microscopically at site and number of animals with lesion b Average severity grade (1-minimal;2-mild;3-moderate;4-marked) Page 7 ------------------------------------------------------------ ---------- END OF REPORT ---------- ------------------------------------------------------------