TDMS Study 97013-14 Pathology Tables
NTP Experiment-Test: 97013-14 INCIDENCE RATES OF NONNEOPLASTIC LESIONS BY ANATOMIC SITE (a) Report: PEIRPT18
Study Type: SUBCHRON 26-WEEK WITH AVERAGE SEVERITY GRADES[b] Date: 01/27/05
Route: DOSED WATER WATER DISINFECTION MODEL (DICHLOROACETIC ACID) Time: 09:31:44
FINAL #1/P53
Facility: Battelle Columbus Laboratory
Chemical CAS #: 79-43-6
Lock Date: 07/31/01
Cage Range: All
Reasons For Removal: 25019 Moribund Sacrifice 25020 Natural Death
25021 Terminal Sacrifice
Removal Date Range: All
Treatment Groups: Include All
a Number of animals examined microscopically at site and number of animals with lesion
b Average severity grade (1-minimal;2-mild;3-moderate;4-marked)
Page 1
NTP Experiment-Test: 97013-14 INCIDENCE RATES OF NONNEOPLASTIC LESIONS BY ANATOMIC SITE (a) Report: PEIRPT18
Study Type: SUBCHRON 26-WEEK WITH AVERAGE SEVERITY GRADES[b] Date: 01/27/05
Route: DOSED WATER WATER DISINFECTION MODEL (DICHLOROACETIC ACID) Time: 09:31:44
____________________________________________________________________________________________________________________________________
P53+/-(C57BL/6) FEMALE 0 MG/L 500 MG/L 1000MG/L 2000MG/L
____________________________________________________________________________________________________________________________________
DISPOSITION SUMMARY
Animals Initially In Study 15 15 15 15
Early Deaths
Natural Death 1
Moribund Sacrifice 1
Survivors
Terminal Sacrifice 15 15 14 14
Animals Examined Microscopically 15 15 15 15
____________________________________________________________________________________________________________________________________
ALIMENTARY SYSTEM
Liver (15) (15) (15) (15)
Inflammation, Chronic Active 15 [1.2] 14 [1.1] 13 [1.2] 14 [1.1]
Hepatocyte, Necrosis 1 [1.0]
Hepatocyte, Vacuolization Cytoplasmic 3 [1.0] 15 [2.2] 15 [3.1] 15 [3.5]
Stomach, Forestomach (15) (15) (15) (15)
Inflammation, Chronic Active 1 [1.0]
____________________________________________________________________________________________________________________________________
CARDIOVASCULAR SYSTEM
None
____________________________________________________________________________________________________________________________________
ENDOCRINE SYSTEM
Adrenal Cortex (15) (15) (15) (15)
Accessory Adrenal Cortical Nodule 4 [1.5] 2 [2.0] 1 [1.0]
Subcapsular, Hyperplasia 14 [1.0] 14 [1.0] 15 [1.0] 14 [1.1]
Parathyroid Gland (1)
Cyst 1 [2.0]
Pituitary Gland (15) (15) (15) (15)
Pars Distalis, Cyst 1 [1.0] 2 [1.0] 3 [1.0]
Pars Distalis, Hyperplasia 1 [1.0] 3 [1.0] 5 [1.0]
Thyroid Gland (15) (15) (15) (15)
Ectopic Thymus 1 [2.0]
Infiltration Cellular, Lymphocyte 2 [2.0] 1 [2.0]
Follicle, Degeneration 1 [1.0] 3 [1.0]
____________________________________________________________________________________________________________________________________
GENERAL BODY SYSTEM
a Number of animals examined microscopically at site and number of animals with lesion
b Average severity grade (1-minimal;2-mild;3-moderate;4-marked)
Page 2
NTP Experiment-Test: 97013-14 INCIDENCE RATES OF NONNEOPLASTIC LESIONS BY ANATOMIC SITE (a) Report: PEIRPT18
Study Type: SUBCHRON 26-WEEK WITH AVERAGE SEVERITY GRADES[b] Date: 01/27/05
Route: DOSED WATER WATER DISINFECTION MODEL (DICHLOROACETIC ACID) Time: 09:31:44
____________________________________________________________________________________________________________________________________
P53+/-(C57BL/6) FEMALE 0 MG/L 500 MG/L 1000MG/L 2000MG/L
____________________________________________________________________________________________________________________________________
None
____________________________________________________________________________________________________________________________________
GENITAL SYSTEM
Ovary (15) (15) (15) (15)
Cyst 2 [2.5] 1 [2.0] 1 [2.0]
Uterus (15) (15) (15) (15)
Inflammation, Chronic Active 1 [3.0] 1 [1.0]
Endometrium, Hyperplasia, Cystic 8 [1.5] 12 [1.9] 13 [1.6] 13 [1.4]
____________________________________________________________________________________________________________________________________
HEMATOPOIETIC SYSTEM
Lymph Node (1)
Mediastinal, Hyperplasia, Lymphoid 1 [3.0]
Lymph Node, Mandibular (15) (15) (15) (15)
Hyperplasia, Lymphoid 1 [2.0] 4 [2.3] 4 [2.5]
Lymph Node, Mesenteric (15) (15) (15) (15)
Hyperplasia, Lymphoid 1 [2.0]
Spleen (15) (15) (15) (15)
Atrophy 1 [2.0]
Thymus (15) (15) (15) (15)
Atrophy 1 [3.0]
Cyst 10 [1.6] 11 [1.8] 11 [1.6] 12 [1.7]
Ectopic Parathyroid Gland 2 [1.5] 2 [1.0] 1 [1.0] 2 [1.0]
Thymocyte, Necrosis 6 [1.8] 2 [2.0] 1 [2.0]
____________________________________________________________________________________________________________________________________
INTEGUMENTARY SYSTEM
None
____________________________________________________________________________________________________________________________________
MUSCULOSKELETAL SYSTEM
None
____________________________________________________________________________________________________________________________________
NERVOUS SYSTEM
None
____________________________________________________________________________________________________________________________________
a Number of animals examined microscopically at site and number of animals with lesion
b Average severity grade (1-minimal;2-mild;3-moderate;4-marked)
Page 3
NTP Experiment-Test: 97013-14 INCIDENCE RATES OF NONNEOPLASTIC LESIONS BY ANATOMIC SITE (a) Report: PEIRPT18
Study Type: SUBCHRON 26-WEEK WITH AVERAGE SEVERITY GRADES[b] Date: 01/27/05
Route: DOSED WATER WATER DISINFECTION MODEL (DICHLOROACETIC ACID) Time: 09:31:44
____________________________________________________________________________________________________________________________________
P53+/-(C57BL/6) FEMALE 0 MG/L 500 MG/L 1000MG/L 2000MG/L
____________________________________________________________________________________________________________________________________
RESPIRATORY SYSTEM
Lung (15) (15) (15) (15)
Inflammation, Chronic Active 2 [1.5] 3 [1.0] 1 [2.0]
Alveolus, Infiltration Cellular, Histiocyte 1 [3.0]
____________________________________________________________________________________________________________________________________
SPECIAL SENSES SYSTEM
None
____________________________________________________________________________________________________________________________________
URINARY SYSTEM
Kidney (15) (15) (15) (15)
Cyst 1 [3.0]
Mineralization 4 [1.0] 1 [1.0]
Nephropathy 3 [1.0] 11 [1.0] 7 [1.0] 9 [1.0]
Renal Tubule, Dilatation 2 [2.0] 1 [2.0]
a Number of animals examined microscopically at site and number of animals with lesion
b Average severity grade (1-minimal;2-mild;3-moderate;4-marked)
Page 4
NTP Experiment-Test: 97013-14 INCIDENCE RATES OF NONNEOPLASTIC LESIONS BY ANATOMIC SITE (a) Report: PEIRPT18
Study Type: SUBCHRON 26-WEEK WITH AVERAGE SEVERITY GRADES[b] Date: 01/27/05
Route: DOSED WATER WATER DISINFECTION MODEL (DICHLOROACETIC ACID) Time: 09:31:44
____________________________________________________________________________________________________________________________________
P53+/-(C57BL/6) MALE 0 MG/L 500 MG/L 1000MG/L 2000MG/L
____________________________________________________________________________________________________________________________________
DISPOSITION SUMMARY
Animals Initially In Study 15 15 15 15
Early Deaths
Survivors
Terminal Sacrifice 15 15 15 15
Animals Examined Microscopically 15 15 15 15
____________________________________________________________________________________________________________________________________
ALIMENTARY SYSTEM
Liver (15) (15) (15) (15)
Hematopoietic Cell Proliferation 1 [1.0]
Inflammation, Chronic Active 15 [1.0] 13 [1.0] 15 [1.1] 13 [1.0]
Hepatocyte, Fatty Change 10 [1.1] 2 [1.0] 1 [1.0]
Hepatocyte, Necrosis 1 [1.0] 1 [1.0]
Hepatocyte, Vacuolization Cytoplasmic 15 [2.7] 15 [3.4] 15 [3.4] 15 [4.0]
____________________________________________________________________________________________________________________________________
CARDIOVASCULAR SYSTEM
None
____________________________________________________________________________________________________________________________________
ENDOCRINE SYSTEM
Adrenal Cortex (15) (15) (15) (15)
Accessory Adrenal Cortical Nodule 1 [1.0] 1 [2.0]
Hypertrophy 1 [2.0] 1 [2.0] 2 [1.5]
Subcapsular, Hyperplasia 4 [1.0] 3 [1.0] 3 [1.0]
Pituitary Gland (15) (15) (15) (15)
Pars Distalis, Cyst 3 [1.0] 2 [1.0] 2 [1.0] 1 [1.0]
Pars Distalis, Hyperplasia 6 [1.0]
Thyroid Gland (15) (15) (15) (15)
Ectopic Thymus 2 [1.5]
Follicle, Cyst 1 [2.0]
____________________________________________________________________________________________________________________________________
GENERAL BODY SYSTEM
None
____________________________________________________________________________________________________________________________________
a Number of animals examined microscopically at site and number of animals with lesion
b Average severity grade (1-minimal;2-mild;3-moderate;4-marked)
Page 5
NTP Experiment-Test: 97013-14 INCIDENCE RATES OF NONNEOPLASTIC LESIONS BY ANATOMIC SITE (a) Report: PEIRPT18
Study Type: SUBCHRON 26-WEEK WITH AVERAGE SEVERITY GRADES[b] Date: 01/27/05
Route: DOSED WATER WATER DISINFECTION MODEL (DICHLOROACETIC ACID) Time: 09:31:44
____________________________________________________________________________________________________________________________________
P53+/-(C57BL/6) MALE 0 MG/L 500 MG/L 1000MG/L 2000MG/L
____________________________________________________________________________________________________________________________________
GENITAL SYSTEM
Epididymis (15) (15) (15) (15)
Granuloma Sperm 1 [3.0]
Infiltration Cellular, Lymphocyte 3 [1.3]
Inflammation, Chronic Active 1 [1.0]
Testes (15) (15) (15) (15)
Mineralization 1 [1.0] 1 [1.0]
Germinal Epithelium, Degeneration 2 [1.0] 4 [1.0] 3 [1.0] 1 [1.0]
____________________________________________________________________________________________________________________________________
HEMATOPOIETIC SYSTEM
Lymph Node, Mandibular (15) (15) (15) (15)
Hyperplasia, Lymphoid 2 [2.0] 1 [2.0]
Lymph Node, Mesenteric (15) (15) (15) (15)
Hyperplasia, Lymphoid 1 [2.0] 1 [2.0]
Thymus (15) (15) (15) (15)
Cyst 9 [1.4] 9 [1.9] 9 [1.4] 9 [1.3]
Ectopic Parathyroid Gland 1 [1.0]
Hyperplasia, Lymphoid 1 [2.0]
____________________________________________________________________________________________________________________________________
INTEGUMENTARY SYSTEM
None
____________________________________________________________________________________________________________________________________
MUSCULOSKELETAL SYSTEM
None
____________________________________________________________________________________________________________________________________
NERVOUS SYSTEM
None
____________________________________________________________________________________________________________________________________
RESPIRATORY SYSTEM
None
____________________________________________________________________________________________________________________________________
SPECIAL SENSES SYSTEM
a Number of animals examined microscopically at site and number of animals with lesion
b Average severity grade (1-minimal;2-mild;3-moderate;4-marked)
Page 6
NTP Experiment-Test: 97013-14 INCIDENCE RATES OF NONNEOPLASTIC LESIONS BY ANATOMIC SITE (a) Report: PEIRPT18
Study Type: SUBCHRON 26-WEEK WITH AVERAGE SEVERITY GRADES[b] Date: 01/27/05
Route: DOSED WATER WATER DISINFECTION MODEL (DICHLOROACETIC ACID) Time: 09:31:44
____________________________________________________________________________________________________________________________________
P53+/-(C57BL/6) MALE 0 MG/L 500 MG/L 1000MG/L 2000MG/L
____________________________________________________________________________________________________________________________________
None
____________________________________________________________________________________________________________________________________
URINARY SYSTEM
Kidney (15) (15) (15) (15)
Mineralization 1 [1.0]
Nephropathy 8 [1.0] 10 [1.0] 11 [1.0] 12 [1.0]
Renal Tubule, Dilatation 2 [1.5] 4 [1.8] 2 [1.5]
a Number of animals examined microscopically at site and number of animals with lesion
b Average severity grade (1-minimal;2-mild;3-moderate;4-marked)
Page 7
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