TDMS Study 97013-15 Pathology Tables
NTP Experiment-Test: 97013-15 INCIDENCE RATES OF NONNEOPLASTIC LESIONS BY ANATOMIC SITE (a) Report: PEIRPT03 Study Type: SUBCHRON 26-WEEK WATER DISINFECTION MODEL (DICHLOROACETIC ACID) Date: 01/27/05 Route: SKIN APPLICATION Time: 10:06:53 FINAL #1 TGAC MICE Facility: Battelle Columbus Laboratory Chemical CAS #: 79-43-6 Lock Date: 07/13/01 Cage Range: All Reasons For Removal: 25019 Moribund Sacrifice 25020 Natural Death 25021 Terminal Sacrifice Removal Date Range: All Treatment Groups: Include 001 0 MG/KG Include 002 0 MG/KG Include 003 31.25 MG/KG Include 004 31.25 MG/KG Include 005 125MG/KG Include 006 125MG/KG Include 007 500MG/KG Include 008 500MG/KG a Number of animals examined microscopically at site and number of animals with lesion Page 1 NTP Experiment-Test: 97013-15 INCIDENCE RATES OF NONNEOPLASTIC LESIONS BY ANATOMIC SITE (a) Report: PEIRPT03 Study Type: SUBCHRON 26-WEEK WATER DISINFECTION MODEL (DICHLOROACETIC ACID) Date: 01/27/05 Route: SKIN APPLICATION Time: 10:06:53 ____________________________________________________________________________________________________________________________________ TGAC (FVB/N) HEMIZYGOUS FEMALE 0 MG/KG 31.25 125MG/KG 500MG/KG MG/KG ____________________________________________________________________________________________________________________________________ DISPOSITION SUMMARY Animals Initially In Study 15 15 15 15 Early Deaths Natural Death 4 2 1 Moribund Sacrifice 1 Survivors Terminal Sacrifice 11 12 14 15 Animals Examined Microscopically 15 15 15 15 ____________________________________________________________________________________________________________________________________ ALIMENTARY SYSTEM Liver (15) (15) (15) (15) Inflammation, Chronic Active 11 (73%) 13 (87%) 14 (93%) 11 (73%) Hepatocyte, Necrosis 1 (7%) 3 (20%) Hepatocyte, Vacuolization Cytoplasmic 6 (40%) 4 (27%) 14 (93%) 15 (100%) Stomach, Forestomach (15) (15) (15) (15) Epithelium, Hyperkeratosis 1 (7%) Epithelium, Hyperplasia 1 (7%) 1 (7%) 1 (7%) ____________________________________________________________________________________________________________________________________ CARDIOVASCULAR SYSTEM None ____________________________________________________________________________________________________________________________________ ENDOCRINE SYSTEM Adrenal Cortex (15) (15) (15) (15) Accessory Adrenal Cortical Nodule 2 (13%) 7 (47%) 4 (27%) Subcapsular, Hyperplasia 5 (33%) 8 (53%) 6 (40%) 9 (60%) Pituitary Gland (15) (15) (15) (15) Pars Distalis, Cyst 3 (20%) 4 (27%) 3 (20%) 3 (20%) Thyroid Gland (15) (15) (15) (15) Ectopic Thymus 1 (7%) Follicle, Degeneration 5 (33%) 4 (27%) 2 (13%) 1 (7%) Follicular Cell, Hyperplasia 1 (7%) ____________________________________________________________________________________________________________________________________ GENERAL BODY SYSTEM None a Number of animals examined microscopically at site and number of animals with lesion Page 2 NTP Experiment-Test: 97013-15 INCIDENCE RATES OF NONNEOPLASTIC LESIONS BY ANATOMIC SITE (a) Report: PEIRPT03 Study Type: SUBCHRON 26-WEEK WATER DISINFECTION MODEL (DICHLOROACETIC ACID) Date: 01/27/05 Route: SKIN APPLICATION Time: 10:06:53 ____________________________________________________________________________________________________________________________________ TGAC (FVB/N) HEMIZYGOUS FEMALE 0 MG/KG 31.25 125MG/KG 500MG/KG MG/KG ____________________________________________________________________________________________________________________________________ GENITAL SYSTEM Ovary (15) (15) (15) (15) Cyst 3 (20%) 2 (13%) 1 (7%) 1 (7%) Uterus (15) (15) (15) (15) Endometrium, Hyperplasia, Cystic 10 (67%) 12 (80%) 10 (67%) 14 (93%) ____________________________________________________________________________________________________________________________________ HEMATOPOIETIC SYSTEM Lymph Node, Mandibular (15) (15) (15) (15) Hyperplasia, Lymphoid 3 (20%) 1 (7%) 4 (27%) 2 (13%) Thymus (15) (15) (15) (15) Atrophy 3 (20%) 1 (7%) 1 (7%) Cyst 3 (20%) 8 (53%) 7 (47%) 9 (60%) ____________________________________________________________________________________________________________________________________ INTEGUMENTARY SYSTEM Skin (15) (15) (15) (15) Hyperkeratosis 1 (7%) 1 (7%) Inflammation, Chronic Active 1 (7%) Epidermis, Hyperplasia 3 (20%) 1 (7%) 1 (7%) 2 (13%) Site of Application - Epidermis, Hyperkeratosis 8 (53%) 9 (60%) 14 (93%) 14 (93%) Site of Application - Epidermis, Hyperplasia 1 (7%) 10 (67%) 13 (87%) ____________________________________________________________________________________________________________________________________ MUSCULOSKELETAL SYSTEM None ____________________________________________________________________________________________________________________________________ NERVOUS SYSTEM None ____________________________________________________________________________________________________________________________________ RESPIRATORY SYSTEM Lung (15) (15) (15) (14) Inflammation, Chronic Active 1 (7%) 1 (7%) Thrombosis 1 (7%) a Number of animals examined microscopically at site and number of animals with lesion Page 3 NTP Experiment-Test: 97013-15 INCIDENCE RATES OF NONNEOPLASTIC LESIONS BY ANATOMIC SITE (a) Report: PEIRPT03 Study Type: SUBCHRON 26-WEEK WATER DISINFECTION MODEL (DICHLOROACETIC ACID) Date: 01/27/05 Route: SKIN APPLICATION Time: 10:06:53 ____________________________________________________________________________________________________________________________________ TGAC (FVB/N) HEMIZYGOUS FEMALE 0 MG/KG 31.25 125MG/KG 500MG/KG MG/KG ____________________________________________________________________________________________________________________________________ RESPIRATORY SYSTEM - CONT Alveolar Epithelium, Hyperplasia 1 (7%) 1 (7%) ____________________________________________________________________________________________________________________________________ SPECIAL SENSES SYSTEM None ____________________________________________________________________________________________________________________________________ URINARY SYSTEM Kidney (15) (15) (15) (15) Nephropathy 3 (20%) 6 (40%) 5 (33%) 5 (33%) Renal Tubule, Dilatation 2 (13%) 3 (20%) 3 (20%) 1 (7%) Renal Tubule, Hyperplasia 1 (7%) a Number of animals examined microscopically at site and number of animals with lesion Page 4 NTP Experiment-Test: 97013-15 INCIDENCE RATES OF NONNEOPLASTIC LESIONS BY ANATOMIC SITE (a) Report: PEIRPT03 Study Type: SUBCHRON 26-WEEK WATER DISINFECTION MODEL (DICHLOROACETIC ACID) Date: 01/27/05 Route: SKIN APPLICATION Time: 10:06:53 ____________________________________________________________________________________________________________________________________ TGAC (FVB/N) HEMIZYGOUS MALE 0 MG/KG 31.25 125MG/KG 500MG/KG MG/KG ____________________________________________________________________________________________________________________________________ DISPOSITION SUMMARY Animals Initially In Study 15 15 15 15 Early Deaths Moribund Sacrifice 2 2 Natural Death 1 1 1 Survivors Terminal Sacrifice 13 14 14 12 Animals Examined Microscopically 15 15 15 15 ____________________________________________________________________________________________________________________________________ ALIMENTARY SYSTEM Liver (15) (15) (15) (15) Hematopoietic Cell Proliferation 3 (20%) Inflammation, Chronic Active 2 (13%) 8 (53%) 4 (27%) 2 (13%) Pigmentation 1 (7%) Hepatocyte, Necrosis 1 (7%) 2 (13%) 2 (13%) Hepatocyte, Vacuolization Cytoplasmic 3 (20%) 4 (27%) 14 (93%) 15 (100%) Stomach, Forestomach (15) (15) (15) (15) Epithelium, Hyperkeratosis 1 (7%) Epithelium, Hyperplasia 1 (7%) 1 (7%) ____________________________________________________________________________________________________________________________________ CARDIOVASCULAR SYSTEM None ____________________________________________________________________________________________________________________________________ ENDOCRINE SYSTEM Adrenal Cortex (15) (15) (15) (15) Hypertrophy 11 (73%) 7 (47%) 7 (47%) 7 (47%) Subcapsular, Hyperplasia 4 (27%) 1 (7%) 2 (13%) Parathyroid Gland (1) Cyst 1 (100%) Pituitary Gland (15) (15) (14) (15) Pars Distalis, Cyst 1 (7%) 3 (20%) Thyroid Gland (15) (15) (15) (15) Follicle, Degeneration 3 (20%) 3 (20%) 2 (13%) 1 (7%) ____________________________________________________________________________________________________________________________________ GENERAL BODY SYSTEM a Number of animals examined microscopically at site and number of animals with lesion Page 5 NTP Experiment-Test: 97013-15 INCIDENCE RATES OF NONNEOPLASTIC LESIONS BY ANATOMIC SITE (a) Report: PEIRPT03 Study Type: SUBCHRON 26-WEEK WATER DISINFECTION MODEL (DICHLOROACETIC ACID) Date: 01/27/05 Route: SKIN APPLICATION Time: 10:06:53 ____________________________________________________________________________________________________________________________________ TGAC (FVB/N) HEMIZYGOUS MALE 0 MG/KG 31.25 125MG/KG 500MG/KG MG/KG ____________________________________________________________________________________________________________________________________ None ____________________________________________________________________________________________________________________________________ GENITAL SYSTEM Epididymis (15) (15) (15) (15) Degeneration 2 (13%) 1 (7%) 1 (7%) 1 (7%) Inflammation, Chronic Active 1 (7%) Testes (15) (15) (15) (15) Cyst 1 (7%) 1 (7%) 1 (7%) Germinal Epithelium, Degeneration 2 (13%) 1 (7%) 1 (7%) 2 (13%) ____________________________________________________________________________________________________________________________________ HEMATOPOIETIC SYSTEM Lymph Node, Mandibular (15) (15) (15) (14) Hyperplasia, Lymphoid 2 (13%) 1 (7%) Spleen (15) (15) (15) (15) Hematopoietic Cell Proliferation 3 (20%) Thymus (15) (15) (15) (15) Atrophy 1 (7%) 1 (7%) 2 (13%) Cyst 6 (40%) 1 (7%) 4 (27%) 2 (13%) Thymocyte, Necrosis 2 (13%) ____________________________________________________________________________________________________________________________________ INTEGUMENTARY SYSTEM Skin (15) (15) (15) (15) Epidermis, Hyperplasia 2 (13%) 3 (20%) 2 (13%) 3 (20%) Site of Application - Epidermis, Hyperkeratosis 2 (13%) 7 (47%) 15 (100%) 14 (93%) Site of Application - Epidermis, Hyperplasia 2 (13%) 11 (73%) 13 (87%) ____________________________________________________________________________________________________________________________________ MUSCULOSKELETAL SYSTEM None ____________________________________________________________________________________________________________________________________ NERVOUS SYSTEM None ____________________________________________________________________________________________________________________________________ a Number of animals examined microscopically at site and number of animals with lesion Page 6 NTP Experiment-Test: 97013-15 INCIDENCE RATES OF NONNEOPLASTIC LESIONS BY ANATOMIC SITE (a) Report: PEIRPT03 Study Type: SUBCHRON 26-WEEK WATER DISINFECTION MODEL (DICHLOROACETIC ACID) Date: 01/27/05 Route: SKIN APPLICATION Time: 10:06:53 ____________________________________________________________________________________________________________________________________ TGAC (FVB/N) HEMIZYGOUS MALE 0 MG/KG 31.25 125MG/KG 500MG/KG MG/KG ____________________________________________________________________________________________________________________________________ RESPIRATORY SYSTEM Lung (15) (15) (15) (15) Inflammation, Chronic Active 1 (7%) 1 (7%) Pigmentation 1 (7%) ____________________________________________________________________________________________________________________________________ SPECIAL SENSES SYSTEM None ____________________________________________________________________________________________________________________________________ URINARY SYSTEM Kidney (15) (15) (15) (15) Nephropathy 7 (47%) 7 (47%) 11 (73%) 13 (87%) Renal Tubule, Dilatation 4 (27%) 2 (13%) 2 (13%) a Number of animals examined microscopically at site and number of animals with lesion Page 7 ------------------------------------------------------------ ---------- END OF REPORT ---------- ------------------------------------------------------------