TDMS Study 97013-15 Pathology Tables
NTP Experiment-Test: 97013-15 INCIDENCE RATES OF NONNEOPLASTIC LESIONS BY ANATOMIC SITE (a) Report: PEIRPT03
Study Type: SUBCHRON 26-WEEK WATER DISINFECTION MODEL (DICHLOROACETIC ACID) Date: 01/27/05
Route: SKIN APPLICATION Time: 10:06:53
FINAL #1 TGAC MICE
Facility: Battelle Columbus Laboratory
Chemical CAS #: 79-43-6
Lock Date: 07/13/01
Cage Range: All
Reasons For Removal: 25019 Moribund Sacrifice 25020 Natural Death
25021 Terminal Sacrifice
Removal Date Range: All
Treatment Groups: Include 001 0 MG/KG
Include 002 0 MG/KG
Include 003 31.25 MG/KG
Include 004 31.25 MG/KG
Include 005 125MG/KG
Include 006 125MG/KG
Include 007 500MG/KG
Include 008 500MG/KG
a Number of animals examined microscopically at site and number of animals with lesion
Page 1
NTP Experiment-Test: 97013-15 INCIDENCE RATES OF NONNEOPLASTIC LESIONS BY ANATOMIC SITE (a) Report: PEIRPT03
Study Type: SUBCHRON 26-WEEK WATER DISINFECTION MODEL (DICHLOROACETIC ACID) Date: 01/27/05
Route: SKIN APPLICATION Time: 10:06:53
____________________________________________________________________________________________________________________________________
TGAC (FVB/N) HEMIZYGOUS FEMALE 0 MG/KG 31.25 125MG/KG 500MG/KG
MG/KG
____________________________________________________________________________________________________________________________________
DISPOSITION SUMMARY
Animals Initially In Study 15 15 15 15
Early Deaths
Natural Death 4 2 1
Moribund Sacrifice 1
Survivors
Terminal Sacrifice 11 12 14 15
Animals Examined Microscopically 15 15 15 15
____________________________________________________________________________________________________________________________________
ALIMENTARY SYSTEM
Liver (15) (15) (15) (15)
Inflammation, Chronic Active 11 (73%) 13 (87%) 14 (93%) 11 (73%)
Hepatocyte, Necrosis 1 (7%) 3 (20%)
Hepatocyte, Vacuolization Cytoplasmic 6 (40%) 4 (27%) 14 (93%) 15 (100%)
Stomach, Forestomach (15) (15) (15) (15)
Epithelium, Hyperkeratosis 1 (7%)
Epithelium, Hyperplasia 1 (7%) 1 (7%) 1 (7%)
____________________________________________________________________________________________________________________________________
CARDIOVASCULAR SYSTEM
None
____________________________________________________________________________________________________________________________________
ENDOCRINE SYSTEM
Adrenal Cortex (15) (15) (15) (15)
Accessory Adrenal Cortical Nodule 2 (13%) 7 (47%) 4 (27%)
Subcapsular, Hyperplasia 5 (33%) 8 (53%) 6 (40%) 9 (60%)
Pituitary Gland (15) (15) (15) (15)
Pars Distalis, Cyst 3 (20%) 4 (27%) 3 (20%) 3 (20%)
Thyroid Gland (15) (15) (15) (15)
Ectopic Thymus 1 (7%)
Follicle, Degeneration 5 (33%) 4 (27%) 2 (13%) 1 (7%)
Follicular Cell, Hyperplasia 1 (7%)
____________________________________________________________________________________________________________________________________
GENERAL BODY SYSTEM
None
a Number of animals examined microscopically at site and number of animals with lesion
Page 2
NTP Experiment-Test: 97013-15 INCIDENCE RATES OF NONNEOPLASTIC LESIONS BY ANATOMIC SITE (a) Report: PEIRPT03
Study Type: SUBCHRON 26-WEEK WATER DISINFECTION MODEL (DICHLOROACETIC ACID) Date: 01/27/05
Route: SKIN APPLICATION Time: 10:06:53
____________________________________________________________________________________________________________________________________
TGAC (FVB/N) HEMIZYGOUS FEMALE 0 MG/KG 31.25 125MG/KG 500MG/KG
MG/KG
____________________________________________________________________________________________________________________________________
GENITAL SYSTEM
Ovary (15) (15) (15) (15)
Cyst 3 (20%) 2 (13%) 1 (7%) 1 (7%)
Uterus (15) (15) (15) (15)
Endometrium, Hyperplasia, Cystic 10 (67%) 12 (80%) 10 (67%) 14 (93%)
____________________________________________________________________________________________________________________________________
HEMATOPOIETIC SYSTEM
Lymph Node, Mandibular (15) (15) (15) (15)
Hyperplasia, Lymphoid 3 (20%) 1 (7%) 4 (27%) 2 (13%)
Thymus (15) (15) (15) (15)
Atrophy 3 (20%) 1 (7%) 1 (7%)
Cyst 3 (20%) 8 (53%) 7 (47%) 9 (60%)
____________________________________________________________________________________________________________________________________
INTEGUMENTARY SYSTEM
Skin (15) (15) (15) (15)
Hyperkeratosis 1 (7%) 1 (7%)
Inflammation, Chronic Active 1 (7%)
Epidermis, Hyperplasia 3 (20%) 1 (7%) 1 (7%) 2 (13%)
Site of Application - Epidermis,
Hyperkeratosis 8 (53%) 9 (60%) 14 (93%) 14 (93%)
Site of Application - Epidermis, Hyperplasia 1 (7%) 10 (67%) 13 (87%)
____________________________________________________________________________________________________________________________________
MUSCULOSKELETAL SYSTEM
None
____________________________________________________________________________________________________________________________________
NERVOUS SYSTEM
None
____________________________________________________________________________________________________________________________________
RESPIRATORY SYSTEM
Lung (15) (15) (15) (14)
Inflammation, Chronic Active 1 (7%) 1 (7%)
Thrombosis 1 (7%)
a Number of animals examined microscopically at site and number of animals with lesion
Page 3
NTP Experiment-Test: 97013-15 INCIDENCE RATES OF NONNEOPLASTIC LESIONS BY ANATOMIC SITE (a) Report: PEIRPT03
Study Type: SUBCHRON 26-WEEK WATER DISINFECTION MODEL (DICHLOROACETIC ACID) Date: 01/27/05
Route: SKIN APPLICATION Time: 10:06:53
____________________________________________________________________________________________________________________________________
TGAC (FVB/N) HEMIZYGOUS FEMALE 0 MG/KG 31.25 125MG/KG 500MG/KG
MG/KG
____________________________________________________________________________________________________________________________________
RESPIRATORY SYSTEM - CONT
Alveolar Epithelium, Hyperplasia 1 (7%) 1 (7%)
____________________________________________________________________________________________________________________________________
SPECIAL SENSES SYSTEM
None
____________________________________________________________________________________________________________________________________
URINARY SYSTEM
Kidney (15) (15) (15) (15)
Nephropathy 3 (20%) 6 (40%) 5 (33%) 5 (33%)
Renal Tubule, Dilatation 2 (13%) 3 (20%) 3 (20%) 1 (7%)
Renal Tubule, Hyperplasia 1 (7%)
a Number of animals examined microscopically at site and number of animals with lesion
Page 4
NTP Experiment-Test: 97013-15 INCIDENCE RATES OF NONNEOPLASTIC LESIONS BY ANATOMIC SITE (a) Report: PEIRPT03
Study Type: SUBCHRON 26-WEEK WATER DISINFECTION MODEL (DICHLOROACETIC ACID) Date: 01/27/05
Route: SKIN APPLICATION Time: 10:06:53
____________________________________________________________________________________________________________________________________
TGAC (FVB/N) HEMIZYGOUS MALE 0 MG/KG 31.25 125MG/KG 500MG/KG
MG/KG
____________________________________________________________________________________________________________________________________
DISPOSITION SUMMARY
Animals Initially In Study 15 15 15 15
Early Deaths
Moribund Sacrifice 2 2
Natural Death 1 1 1
Survivors
Terminal Sacrifice 13 14 14 12
Animals Examined Microscopically 15 15 15 15
____________________________________________________________________________________________________________________________________
ALIMENTARY SYSTEM
Liver (15) (15) (15) (15)
Hematopoietic Cell Proliferation 3 (20%)
Inflammation, Chronic Active 2 (13%) 8 (53%) 4 (27%) 2 (13%)
Pigmentation 1 (7%)
Hepatocyte, Necrosis 1 (7%) 2 (13%) 2 (13%)
Hepatocyte, Vacuolization Cytoplasmic 3 (20%) 4 (27%) 14 (93%) 15 (100%)
Stomach, Forestomach (15) (15) (15) (15)
Epithelium, Hyperkeratosis 1 (7%)
Epithelium, Hyperplasia 1 (7%) 1 (7%)
____________________________________________________________________________________________________________________________________
CARDIOVASCULAR SYSTEM
None
____________________________________________________________________________________________________________________________________
ENDOCRINE SYSTEM
Adrenal Cortex (15) (15) (15) (15)
Hypertrophy 11 (73%) 7 (47%) 7 (47%) 7 (47%)
Subcapsular, Hyperplasia 4 (27%) 1 (7%) 2 (13%)
Parathyroid Gland (1)
Cyst 1 (100%)
Pituitary Gland (15) (15) (14) (15)
Pars Distalis, Cyst 1 (7%) 3 (20%)
Thyroid Gland (15) (15) (15) (15)
Follicle, Degeneration 3 (20%) 3 (20%) 2 (13%) 1 (7%)
____________________________________________________________________________________________________________________________________
GENERAL BODY SYSTEM
a Number of animals examined microscopically at site and number of animals with lesion
Page 5
NTP Experiment-Test: 97013-15 INCIDENCE RATES OF NONNEOPLASTIC LESIONS BY ANATOMIC SITE (a) Report: PEIRPT03
Study Type: SUBCHRON 26-WEEK WATER DISINFECTION MODEL (DICHLOROACETIC ACID) Date: 01/27/05
Route: SKIN APPLICATION Time: 10:06:53
____________________________________________________________________________________________________________________________________
TGAC (FVB/N) HEMIZYGOUS MALE 0 MG/KG 31.25 125MG/KG 500MG/KG
MG/KG
____________________________________________________________________________________________________________________________________
None
____________________________________________________________________________________________________________________________________
GENITAL SYSTEM
Epididymis (15) (15) (15) (15)
Degeneration 2 (13%) 1 (7%) 1 (7%) 1 (7%)
Inflammation, Chronic Active 1 (7%)
Testes (15) (15) (15) (15)
Cyst 1 (7%) 1 (7%) 1 (7%)
Germinal Epithelium, Degeneration 2 (13%) 1 (7%) 1 (7%) 2 (13%)
____________________________________________________________________________________________________________________________________
HEMATOPOIETIC SYSTEM
Lymph Node, Mandibular (15) (15) (15) (14)
Hyperplasia, Lymphoid 2 (13%) 1 (7%)
Spleen (15) (15) (15) (15)
Hematopoietic Cell Proliferation 3 (20%)
Thymus (15) (15) (15) (15)
Atrophy 1 (7%) 1 (7%) 2 (13%)
Cyst 6 (40%) 1 (7%) 4 (27%) 2 (13%)
Thymocyte, Necrosis 2 (13%)
____________________________________________________________________________________________________________________________________
INTEGUMENTARY SYSTEM
Skin (15) (15) (15) (15)
Epidermis, Hyperplasia 2 (13%) 3 (20%) 2 (13%) 3 (20%)
Site of Application - Epidermis,
Hyperkeratosis 2 (13%) 7 (47%) 15 (100%) 14 (93%)
Site of Application - Epidermis, Hyperplasia 2 (13%) 11 (73%) 13 (87%)
____________________________________________________________________________________________________________________________________
MUSCULOSKELETAL SYSTEM
None
____________________________________________________________________________________________________________________________________
NERVOUS SYSTEM
None
____________________________________________________________________________________________________________________________________
a Number of animals examined microscopically at site and number of animals with lesion
Page 6
NTP Experiment-Test: 97013-15 INCIDENCE RATES OF NONNEOPLASTIC LESIONS BY ANATOMIC SITE (a) Report: PEIRPT03
Study Type: SUBCHRON 26-WEEK WATER DISINFECTION MODEL (DICHLOROACETIC ACID) Date: 01/27/05
Route: SKIN APPLICATION Time: 10:06:53
____________________________________________________________________________________________________________________________________
TGAC (FVB/N) HEMIZYGOUS MALE 0 MG/KG 31.25 125MG/KG 500MG/KG
MG/KG
____________________________________________________________________________________________________________________________________
RESPIRATORY SYSTEM
Lung (15) (15) (15) (15)
Inflammation, Chronic Active 1 (7%) 1 (7%)
Pigmentation 1 (7%)
____________________________________________________________________________________________________________________________________
SPECIAL SENSES SYSTEM
None
____________________________________________________________________________________________________________________________________
URINARY SYSTEM
Kidney (15) (15) (15) (15)
Nephropathy 7 (47%) 7 (47%) 11 (73%) 13 (87%)
Renal Tubule, Dilatation 4 (27%) 2 (13%) 2 (13%)
a Number of animals examined microscopically at site and number of animals with lesion
Page 7
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