TDMS Study 97013-15 Pathology Tables
NTP Experiment-Test: 97013-15 INCIDENCE RATES OF NONNEOPLASTIC LESIONS BY ANATOMIC SITE (a) Report: PEIRPT18 Study Type: SUBCHRON 26-WEEK WITH AVERAGE SEVERITY GRADES[b] Date: 01/27/05 Route: SKIN APPLICATION WATER DISINFECTION MODEL (DICHLOROACETIC ACID) Time: 10:09:28 FINAL #1 TGAC MICE Facility: Battelle Columbus Laboratory Chemical CAS #: 79-43-6 Lock Date: 07/13/01 Cage Range: All Reasons For Removal: 25019 Moribund Sacrifice 25020 Natural Death 25021 Terminal Sacrifice Removal Date Range: All Treatment Groups: Include 001 0 MG/KG Include 002 0 MG/KG Include 003 31.25 MG/KG Include 004 31.25 MG/KG Include 005 125MG/KG Include 006 125MG/KG Include 007 500MG/KG Include 008 500MG/KG a Number of animals examined microscopically at site and number of animals with lesion b Average severity grade (1-minimal;2-mild;3-moderate;4-marked) Page 1 NTP Experiment-Test: 97013-15 INCIDENCE RATES OF NONNEOPLASTIC LESIONS BY ANATOMIC SITE (a) Report: PEIRPT18 Study Type: SUBCHRON 26-WEEK WITH AVERAGE SEVERITY GRADES[b] Date: 01/27/05 Route: SKIN APPLICATION WATER DISINFECTION MODEL (DICHLOROACETIC ACID) Time: 10:09:28 ____________________________________________________________________________________________________________________________________ TGAC (FVB/N) HEMIZYGOUS FEMALE 0 MG/KG 31.25 125MG/KG 500MG/KG MG/KG ____________________________________________________________________________________________________________________________________ DISPOSITION SUMMARY Animals Initially In Study 15 15 15 15 Early Deaths Natural Death 4 2 1 Moribund Sacrifice 1 Survivors Terminal Sacrifice 11 12 14 15 Animals Examined Microscopically 15 15 15 15 ____________________________________________________________________________________________________________________________________ ALIMENTARY SYSTEM Liver (15) (15) (15) (15) Inflammation, Chronic Active 11 [1.1] 13 [1.0] 14 [1.1] 11 [1.0] Hepatocyte, Necrosis 1 [1.0] 3 [1.0] Hepatocyte, Vacuolization Cytoplasmic 6 [1.2] 4 [1.0] 14 [2.1] 15 [3.3] Stomach, Forestomach (15) (15) (15) (15) Epithelium, Hyperkeratosis 1 [2.0] Epithelium, Hyperplasia 1 [2.0] 1 [2.0] 1 [2.0] ____________________________________________________________________________________________________________________________________ CARDIOVASCULAR SYSTEM None ____________________________________________________________________________________________________________________________________ ENDOCRINE SYSTEM Adrenal Cortex (15) (15) (15) (15) Accessory Adrenal Cortical Nodule 2 [1.5] 7 [1.3] 4 [1.8] Subcapsular, Hyperplasia 5 [1.0] 8 [1.0] 6 [1.0] 9 [1.0] Pituitary Gland (15) (15) (15) (15) Pars Distalis, Cyst 3 [1.0] 4 [1.0] 3 [1.0] 3 [1.3] Thyroid Gland (15) (15) (15) (15) Ectopic Thymus 1 [2.0] Follicle, Degeneration 5 [1.0] 4 [1.3] 2 [1.5] 1 [1.0] Follicular Cell, Hyperplasia 1 [1.0] ____________________________________________________________________________________________________________________________________ GENERAL BODY SYSTEM None a Number of animals examined microscopically at site and number of animals with lesion b Average severity grade (1-minimal;2-mild;3-moderate;4-marked) Page 2 NTP Experiment-Test: 97013-15 INCIDENCE RATES OF NONNEOPLASTIC LESIONS BY ANATOMIC SITE (a) Report: PEIRPT18 Study Type: SUBCHRON 26-WEEK WITH AVERAGE SEVERITY GRADES[b] Date: 01/27/05 Route: SKIN APPLICATION WATER DISINFECTION MODEL (DICHLOROACETIC ACID) Time: 10:09:28 ____________________________________________________________________________________________________________________________________ TGAC (FVB/N) HEMIZYGOUS FEMALE 0 MG/KG 31.25 125MG/KG 500MG/KG MG/KG ____________________________________________________________________________________________________________________________________ GENITAL SYSTEM Ovary (15) (15) (15) (15) Cyst 3 [2.0] 2 [2.0] 1 [2.0] 1 [2.0] Uterus (15) (15) (15) (15) Endometrium, Hyperplasia, Cystic 10 [1.5] 12 [1.7] 10 [1.6] 14 [1.4] ____________________________________________________________________________________________________________________________________ HEMATOPOIETIC SYSTEM Lymph Node, Mandibular (15) (15) (15) (15) Hyperplasia, Lymphoid 3 [2.3] 1 [2.0] 4 [2.5] 2 [3.5] Thymus (15) (15) (15) (15) Atrophy 3 [3.3] 1 [4.0] 1 [3.0] Cyst 3 [1.3] 8 [1.1] 7 [1.1] 9 [1.3] ____________________________________________________________________________________________________________________________________ INTEGUMENTARY SYSTEM Skin (15) (15) (15) (15) Hyperkeratosis 1 [3.0] 1 [3.0] Inflammation, Chronic Active 1 [2.0] Epidermis, Hyperplasia 3 [2.7] 1 [2.0] 1 [4.0] 2 [2.5] Site of Application - Epidermis, Hyperkeratosis 8 [1.3] 9 [1.0] 14 [1.6] 14 [1.9] Site of Application - Epidermis, Hyperplasia 1 [1.0] 10 [1.0] 13 [1.8] ____________________________________________________________________________________________________________________________________ MUSCULOSKELETAL SYSTEM None ____________________________________________________________________________________________________________________________________ NERVOUS SYSTEM None ____________________________________________________________________________________________________________________________________ RESPIRATORY SYSTEM Lung (15) (15) (15) (14) Inflammation, Chronic Active 1 [1.0] 1 [3.0] Thrombosis 1 [4.0] a Number of animals examined microscopically at site and number of animals with lesion b Average severity grade (1-minimal;2-mild;3-moderate;4-marked) Page 3 NTP Experiment-Test: 97013-15 INCIDENCE RATES OF NONNEOPLASTIC LESIONS BY ANATOMIC SITE (a) Report: PEIRPT18 Study Type: SUBCHRON 26-WEEK WITH AVERAGE SEVERITY GRADES[b] Date: 01/27/05 Route: SKIN APPLICATION WATER DISINFECTION MODEL (DICHLOROACETIC ACID) Time: 10:09:28 ____________________________________________________________________________________________________________________________________ TGAC (FVB/N) HEMIZYGOUS FEMALE 0 MG/KG 31.25 125MG/KG 500MG/KG MG/KG ____________________________________________________________________________________________________________________________________ RESPIRATORY SYSTEM - CONT Alveolar Epithelium, Hyperplasia 1 [2.0] 1 [4.0] ____________________________________________________________________________________________________________________________________ SPECIAL SENSES SYSTEM None ____________________________________________________________________________________________________________________________________ URINARY SYSTEM Kidney (15) (15) (15) (15) Nephropathy 3 [1.0] 6 [1.0] 5 [1.0] 5 [1.0] Renal Tubule, Dilatation 2 [1.5] 3 [1.7] 3 [2.7] 1 [1.0] Renal Tubule, Hyperplasia 1 [2.0] a Number of animals examined microscopically at site and number of animals with lesion b Average severity grade (1-minimal;2-mild;3-moderate;4-marked) Page 4 NTP Experiment-Test: 97013-15 INCIDENCE RATES OF NONNEOPLASTIC LESIONS BY ANATOMIC SITE (a) Report: PEIRPT18 Study Type: SUBCHRON 26-WEEK WITH AVERAGE SEVERITY GRADES[b] Date: 01/27/05 Route: SKIN APPLICATION WATER DISINFECTION MODEL (DICHLOROACETIC ACID) Time: 10:09:28 ____________________________________________________________________________________________________________________________________ TGAC (FVB/N) HEMIZYGOUS MALE 0 MG/KG 31.25 125MG/KG 500MG/KG MG/KG ____________________________________________________________________________________________________________________________________ DISPOSITION SUMMARY Animals Initially In Study 15 15 15 15 Early Deaths Moribund Sacrifice 2 2 Natural Death 1 1 1 Survivors Terminal Sacrifice 13 14 14 12 Animals Examined Microscopically 15 15 15 15 ____________________________________________________________________________________________________________________________________ ALIMENTARY SYSTEM Liver (15) (15) (15) (15) Hematopoietic Cell Proliferation 3 [1.3] Inflammation, Chronic Active 2 [1.0] 8 [1.0] 4 [1.0] 2 [1.5] Pigmentation 1 [1.0] Hepatocyte, Necrosis 1 [2.0] 2 [1.0] 2 [1.5] Hepatocyte, Vacuolization Cytoplasmic 3 [1.0] 4 [1.0] 14 [1.8] 15 [2.8] Stomach, Forestomach (15) (15) (15) (15) Epithelium, Hyperkeratosis 1 [1.0] Epithelium, Hyperplasia 1 [2.0] 1 [2.0] ____________________________________________________________________________________________________________________________________ CARDIOVASCULAR SYSTEM None ____________________________________________________________________________________________________________________________________ ENDOCRINE SYSTEM Adrenal Cortex (15) (15) (15) (15) Hypertrophy 11 [1.2] 7 [1.0] 7 [1.1] 7 [1.0] Subcapsular, Hyperplasia 4 [1.0] 1 [1.0] 2 [1.0] Parathyroid Gland (1) Cyst 1 [2.0] Pituitary Gland (15) (15) (14) (15) Pars Distalis, Cyst 1 [2.0] 3 [1.3] Thyroid Gland (15) (15) (15) (15) Follicle, Degeneration 3 [1.0] 3 [1.3] 2 [1.0] 1 [1.0] ____________________________________________________________________________________________________________________________________ GENERAL BODY SYSTEM a Number of animals examined microscopically at site and number of animals with lesion b Average severity grade (1-minimal;2-mild;3-moderate;4-marked) Page 5 NTP Experiment-Test: 97013-15 INCIDENCE RATES OF NONNEOPLASTIC LESIONS BY ANATOMIC SITE (a) Report: PEIRPT18 Study Type: SUBCHRON 26-WEEK WITH AVERAGE SEVERITY GRADES[b] Date: 01/27/05 Route: SKIN APPLICATION WATER DISINFECTION MODEL (DICHLOROACETIC ACID) Time: 10:09:28 ____________________________________________________________________________________________________________________________________ TGAC (FVB/N) HEMIZYGOUS MALE 0 MG/KG 31.25 125MG/KG 500MG/KG MG/KG ____________________________________________________________________________________________________________________________________ None ____________________________________________________________________________________________________________________________________ GENITAL SYSTEM Epididymis (15) (15) (15) (15) Degeneration 2 [4.0] 1 [4.0] 1 [4.0] 1 [4.0] Inflammation, Chronic Active 1 [1.0] Testes (15) (15) (15) (15) Cyst 1 [3.0] 1 [3.0] 1 [3.0] Germinal Epithelium, Degeneration 2 [3.0] 1 [3.0] 1 [2.0] 2 [1.5] ____________________________________________________________________________________________________________________________________ HEMATOPOIETIC SYSTEM Lymph Node, Mandibular (15) (15) (15) (14) Hyperplasia, Lymphoid 2 [2.0] 1 [3.0] Spleen (15) (15) (15) (15) Hematopoietic Cell Proliferation 3 [2.3] Thymus (15) (15) (15) (15) Atrophy 1 [2.0] 1 [3.0] 2 [2.5] Cyst 6 [1.0] 1 [1.0] 4 [1.0] 2 [1.5] Thymocyte, Necrosis 2 [2.5] ____________________________________________________________________________________________________________________________________ INTEGUMENTARY SYSTEM Skin (15) (15) (15) (15) Epidermis, Hyperplasia 2 [2.5] 3 [3.3] 2 [2.0] 3 [1.7] Site of Application - Epidermis, Hyperkeratosis 2 [1.5] 7 [1.1] 15 [1.9] 14 [2.0] Site of Application - Epidermis, Hyperplasia 2 [1.0] 11 [1.0] 13 [1.8] ____________________________________________________________________________________________________________________________________ MUSCULOSKELETAL SYSTEM None ____________________________________________________________________________________________________________________________________ NERVOUS SYSTEM None ____________________________________________________________________________________________________________________________________ a Number of animals examined microscopically at site and number of animals with lesion b Average severity grade (1-minimal;2-mild;3-moderate;4-marked) Page 6 NTP Experiment-Test: 97013-15 INCIDENCE RATES OF NONNEOPLASTIC LESIONS BY ANATOMIC SITE (a) Report: PEIRPT18 Study Type: SUBCHRON 26-WEEK WITH AVERAGE SEVERITY GRADES[b] Date: 01/27/05 Route: SKIN APPLICATION WATER DISINFECTION MODEL (DICHLOROACETIC ACID) Time: 10:09:28 ____________________________________________________________________________________________________________________________________ TGAC (FVB/N) HEMIZYGOUS MALE 0 MG/KG 31.25 125MG/KG 500MG/KG MG/KG ____________________________________________________________________________________________________________________________________ RESPIRATORY SYSTEM Lung (15) (15) (15) (15) Inflammation, Chronic Active 1 [2.0] 1 [1.0] Pigmentation 1 [1.0] ____________________________________________________________________________________________________________________________________ SPECIAL SENSES SYSTEM None ____________________________________________________________________________________________________________________________________ URINARY SYSTEM Kidney (15) (15) (15) (15) Nephropathy 7 [1.0] 7 [1.0] 11 [1.0] 13 [1.0] Renal Tubule, Dilatation 4 [2.3] 2 [2.0] 2 [2.5] a Number of animals examined microscopically at site and number of animals with lesion b Average severity grade (1-minimal;2-mild;3-moderate;4-marked) Page 7 ------------------------------------------------------------ ---------- END OF REPORT ---------- ------------------------------------------------------------