TDMS Study 97013-89 Pathology Tables
NTP Experiment-Test: 97013-89 INCIDENCE RATES OF NONNEOPLASTIC LESIONS BY ANATOMIC SITE (a) Report: PEIRPT03
Study Type: 26-39 WEEKS WATER DISINFECTION MODEL (DICHLOROACETIC ACID) Date: 12/05/03
Route: SKIN APPLICATION Time: 09:24:30
FINAL#1 MICE
Facility: Battelle Columbus Laboratory
Chemical CAS #: 79-43-6
Lock Date: 07/31/01
Cage Range: All
Reasons For Removal: All
Removal Date Range: All
Treatment Groups: Include All
a Number of animals examined microscopically at site and number of animals with lesion
Page 1
NTP Experiment-Test: 97013-89 INCIDENCE RATES OF NONNEOPLASTIC LESIONS BY ANATOMIC SITE (a) Report: PEIRPT03
Study Type: 26-39 WEEKS WATER DISINFECTION MODEL (DICHLOROACETIC ACID) Date: 12/05/03
Route: SKIN APPLICATION Time: 09:24:30
____________________________________________________________________________________________________________________________________
TGAC (FVB/N) HEMIZYGOUS FEMALE 0 MG/KG 31.25 125MG/KG 500MG/KG
MG/KG
____________________________________________________________________________________________________________________________________
DISPOSITION SUMMARY
Animals Initially In Study 10 10 10 10
Early Deaths
Moribund Sacrifice 2 3 2 2
Natural Death 2 2
Survivors
Terminal Sacrifice 8 5 6 8
Animals Examined Microscopically 10 10 10 10
____________________________________________________________________________________________________________________________________
ALIMENTARY SYSTEM
Liver (10) (10) (10) (10)
Inflammation, Chronic Active 9 (90%) 9 (90%) 8 (80%) 10 (100%)
Hepatocyte, Necrosis 2 (20%) 1 (10%) 5 (50%)
Hepatocyte, Vacuolization Cytoplasmic 7 (70%) 6 (60%) 8 (80%) 10 (100%)
Salivary Glands (1) (1)
Degeneration 1 (100%)
Tooth (4) (2) (3) (3)
Inflammation, Chronic 1 (33%)
____________________________________________________________________________________________________________________________________
CARDIOVASCULAR SYSTEM
None
____________________________________________________________________________________________________________________________________
ENDOCRINE SYSTEM
Adrenal Cortex (10) (10) (10) (10)
Accessory Adrenal Cortical Nodule 3 (30%) 2 (20%)
Mineralization 3 (30%) 1 (10%) 2 (20%)
Subcapsular, Hyperplasia 7 (70%) 6 (60%) 8 (80%) 5 (50%)
Pituitary Gland (10) (10) (9) (10)
Pars Distalis, Cyst 1 (10%) 2 (20%) 2 (22%)
Thyroid Gland (10) (10) (10) (10)
Follicle, Degeneration 2 (20%) 6 (60%) 2 (20%)
____________________________________________________________________________________________________________________________________
GENERAL BODY SYSTEM
None
a Number of animals examined microscopically at site and number of animals with lesion
Page 2
NTP Experiment-Test: 97013-89 INCIDENCE RATES OF NONNEOPLASTIC LESIONS BY ANATOMIC SITE (a) Report: PEIRPT03
Study Type: 26-39 WEEKS WATER DISINFECTION MODEL (DICHLOROACETIC ACID) Date: 12/05/03
Route: SKIN APPLICATION Time: 09:24:30
____________________________________________________________________________________________________________________________________
TGAC (FVB/N) HEMIZYGOUS FEMALE 0 MG/KG 31.25 125MG/KG 500MG/KG
MG/KG
____________________________________________________________________________________________________________________________________
GENITAL SYSTEM
Ovary (10) (10) (10) (10)
Cyst 2 (20%) 1 (10%) 1 (10%) 2 (20%)
Uterus (10) (10) (10) (10)
Inflammation, Chronic Active 1 (10%)
Endometrium, Hyperplasia, Cystic 9 (90%) 8 (80%) 8 (80%) 8 (80%)
____________________________________________________________________________________________________________________________________
HEMATOPOIETIC SYSTEM
Lymph Node, Mandibular (10) (9) (10) (10)
Hyperplasia, Lymphoid 2 (20%) 3 (33%) 3 (30%) 2 (20%)
Spleen (10) (10) (10) (10)
Hematopoietic Cell Proliferation 1 (10%)
Thymus (10) (10) (9) (10)
Atrophy 3 (30%) 3 (30%) 2 (22%) 1 (10%)
Cyst 5 (50%) 2 (20%) 2 (22%) 3 (30%)
Thymocyte, Necrosis 1 (10%)
____________________________________________________________________________________________________________________________________
INTEGUMENTARY SYSTEM
Skin (10) (10) (10) (10)
Fibrosis 1 (10%)
Hyperkeratosis 1 (10%)
Inflammation, Chronic Active 3 (30%)
Ulcer 2 (20%)
Epidermis, Hyperplasia, Focal 1 (10%) 2 (20%)
Site of Application - Epidermis,
Hyperkeratosis 5 (50%) 8 (80%) 9 (90%) 10 (100%)
Site of Application - Epidermis, Hyperplasia 3 (30%) 6 (60%)
Site of Application - Epidermis,
Inflammation, Chronic Active 1 (10%)
____________________________________________________________________________________________________________________________________
MUSCULOSKELETAL SYSTEM
None
____________________________________________________________________________________________________________________________________
NERVOUS SYSTEM
a Number of animals examined microscopically at site and number of animals with lesion
Page 3
NTP Experiment-Test: 97013-89 INCIDENCE RATES OF NONNEOPLASTIC LESIONS BY ANATOMIC SITE (a) Report: PEIRPT03
Study Type: 26-39 WEEKS WATER DISINFECTION MODEL (DICHLOROACETIC ACID) Date: 12/05/03
Route: SKIN APPLICATION Time: 09:24:30
____________________________________________________________________________________________________________________________________
TGAC (FVB/N) HEMIZYGOUS FEMALE 0 MG/KG 31.25 125MG/KG 500MG/KG
MG/KG
____________________________________________________________________________________________________________________________________
NERVOUS SYSTEM - CONT
Spinal Cord (1)
Necrosis 1 (100%)
____________________________________________________________________________________________________________________________________
RESPIRATORY SYSTEM
Lung (10) (10) (10) (10)
Inflammation, Chronic Active 2 (20%)
Alveolar Epithelium, Hyperplasia 1 (10%)
____________________________________________________________________________________________________________________________________
SPECIAL SENSES SYSTEM
None
____________________________________________________________________________________________________________________________________
URINARY SYSTEM
Kidney (10) (10) (10) (10)
Nephropathy 4 (40%) 2 (20%) 3 (30%) 2 (20%)
Glomerulus, Inflammation,
Membranoproliferative 1 (10%)
Renal Tubule, Dilatation 1 (10%) 2 (20%) 1 (10%) 1 (10%)
a Number of animals examined microscopically at site and number of animals with lesion
Page 4
NTP Experiment-Test: 97013-89 INCIDENCE RATES OF NONNEOPLASTIC LESIONS BY ANATOMIC SITE (a) Report: PEIRPT03
Study Type: 26-39 WEEKS WATER DISINFECTION MODEL (DICHLOROACETIC ACID) Date: 12/05/03
Route: SKIN APPLICATION Time: 09:24:30
____________________________________________________________________________________________________________________________________
TGAC (FVB/N) HEMIZYGOUS MALE 0 MG/KG 31.25 125MG/KG 500MG/KG
MG/KG
____________________________________________________________________________________________________________________________________
DISPOSITION SUMMARY
Animals Initially In Study 10 10 10 10
Early Deaths
Moribund Sacrifice 1 3 1 2
Natural Death 1 1 1
Survivors
Terminal Sacrifice 9 6 8 7
Animals Examined Microscopically 10 10 10 10
____________________________________________________________________________________________________________________________________
ALIMENTARY SYSTEM
Liver (10) (10) (10) (10)
Cyst 1 (10%)
Inflammation, Chronic Active 6 (60%) 7 (70%) 5 (50%) 5 (50%)
Mineralization 1 (10%)
Hepatocyte, Necrosis 1 (10%) 2 (20%) 6 (60%)
Hepatocyte, Vacuolization Cytoplasmic 9 (90%) 7 (70%) 8 (80%) 10 (100%)
Mesentery (1) (2)
Fat, Fibrosis 2 (100%)
Fat, Mineralization 1 (100%) 1 (50%)
Fat, Necrosis 1 (100%) 2 (100%)
Salivary Glands (1) (1)
Atrophy 1 (100%) 1 (100%)
Stomach, Forestomach (10) (10) (10) (10)
Epithelium, Hyperkeratosis 1 (10%)
Epithelium, Hyperplasia 1 (10%)
____________________________________________________________________________________________________________________________________
CARDIOVASCULAR SYSTEM
None
____________________________________________________________________________________________________________________________________
ENDOCRINE SYSTEM
Adrenal Cortex (10) (10) (10) (10)
Accessory Adrenal Cortical Nodule 1 (10%)
Hypertrophy 8 (80%) 8 (80%) 6 (60%) 7 (70%)
Subcapsular, Hyperplasia 1 (10%) 1 (10%) 1 (10%)
Pituitary Gland (9) (10) (9) (10)
Pars Distalis, Cyst 2 (20%) 1 (11%)
a Number of animals examined microscopically at site and number of animals with lesion
Page 5
NTP Experiment-Test: 97013-89 INCIDENCE RATES OF NONNEOPLASTIC LESIONS BY ANATOMIC SITE (a) Report: PEIRPT03
Study Type: 26-39 WEEKS WATER DISINFECTION MODEL (DICHLOROACETIC ACID) Date: 12/05/03
Route: SKIN APPLICATION Time: 09:24:30
____________________________________________________________________________________________________________________________________
TGAC (FVB/N) HEMIZYGOUS MALE 0 MG/KG 31.25 125MG/KG 500MG/KG
MG/KG
____________________________________________________________________________________________________________________________________
ENDOCRINE SYSTEM - CONT
Thyroid Gland (10) (10) (10) (10)
Follicle, Degeneration 2 (20%) 2 (20%) 2 (20%) 2 (20%)
____________________________________________________________________________________________________________________________________
GENERAL BODY SYSTEM
None
____________________________________________________________________________________________________________________________________
GENITAL SYSTEM
Epididymis (10) (10) (10) (10)
Degeneration 3 (30%) 2 (20%) 1 (10%) 1 (10%)
Preputial Gland (1)
Duct, Ectasia 1 (100%)
Testes (10) (10) (10) (10)
Cyst 3 (30%) 1 (10%) 1 (10%)
Germinal Epithelium, Degeneration 3 (30%) 2 (20%) 1 (10%) 8 (80%)
____________________________________________________________________________________________________________________________________
HEMATOPOIETIC SYSTEM
Lymph Node, Mandibular (10) (10) (10) (10)
Hyperplasia, Lymphoid 3 (30%) 1 (10%) 1 (10%)
Spleen (10) (10) (10) (10)
Hematopoietic Cell Proliferation 1 (10%)
Thymus (9) (10) (10) (9)
Atrophy 3 (30%) 1 (10%) 4 (44%)
Cyst 3 (33%) 4 (40%) 2 (20%) 3 (33%)
Thymocyte, Necrosis 1 (10%) 1 (11%)
____________________________________________________________________________________________________________________________________
INTEGUMENTARY SYSTEM
Skin (10) (10) (10) (10)
Cyst Epithelial Inclusion 1 (10%)
Hyperplasia 1 (10%) 1 (10%)
Inflammation, Chronic Active 2 (20%)
Epidermis, Hyperplasia, Focal 3 (30%) 1 (10%)
Sebaceous Gland, Cyst 1 (10%)
Site of Application - Dermis, Inflammation,
Chronic Active 1 (10%)
Site of Application - Epidermis,
a Number of animals examined microscopically at site and number of animals with lesion
Page 6
NTP Experiment-Test: 97013-89 INCIDENCE RATES OF NONNEOPLASTIC LESIONS BY ANATOMIC SITE (a) Report: PEIRPT03
Study Type: 26-39 WEEKS WATER DISINFECTION MODEL (DICHLOROACETIC ACID) Date: 12/05/03
Route: SKIN APPLICATION Time: 09:24:30
____________________________________________________________________________________________________________________________________
TGAC (FVB/N) HEMIZYGOUS MALE 0 MG/KG 31.25 125MG/KG 500MG/KG
MG/KG
____________________________________________________________________________________________________________________________________
INTEGUMENTARY SYSTEM - CONT
Hyperkeratosis 2 (20%) 8 (80%) 9 (90%) 10 (100%)
Site of Application - Epidermis, Hyperplasia 8 (80%) 9 (90%)
____________________________________________________________________________________________________________________________________
MUSCULOSKELETAL SYSTEM
None
____________________________________________________________________________________________________________________________________
NERVOUS SYSTEM
None
____________________________________________________________________________________________________________________________________
RESPIRATORY SYSTEM
Lung (10) (10) (10) (10)
Alveolar Epithelium, Hyperplasia 1 (10%)
____________________________________________________________________________________________________________________________________
SPECIAL SENSES SYSTEM
None
____________________________________________________________________________________________________________________________________
URINARY SYSTEM
Kidney (10) (10) (10) (10)
Cyst 2 (20%) 1 (10%)
Infiltration Cellular, Plasma Cell 1 (10%)
Mineralization 2 (20%)
Nephropathy 2 (20%) 7 (70%) 7 (70%) 8 (80%)
Glomerulus, Inflammation,
Membranoproliferative 1 (10%)
Renal Tubule, Dilatation 1 (10%) 4 (40%) 4 (40%) 4 (40%)
a Number of animals examined microscopically at site and number of animals with lesion
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