TDMS Study 97013-89 Pathology Tables
NTP Experiment-Test: 97013-89 INCIDENCE RATES OF NEOPLASMS BY ANATOMIC SITE (SYSTEMIC LESIONS ABRIDGED) (a) Report: PEIRPT05 Study Type: 26-39 WEEKS WATER DISINFECTION MODEL (DICHLOROACETIC ACID) Date: 12/05/03 Route: SKIN APPLICATION Time: 09:26:33 FINAL#1 MICE Facility: Battelle Columbus Laboratory Chemical CAS #: 79-43-6 Lock Date: 07/31/01 Cage Range: All Reasons For Removal: All Removal Date Range: All Treatment Groups: Include All a Number of animals examined microscopically at site and number of animals with lesion Page 1 NTP Experiment-Test: 97013-89 INCIDENCE RATES OF NEOPLASMS BY ANATOMIC SITE (SYSTEMIC LESIONS ABRIDGED) (a) Report: PEIRPT05 Study Type: 26-39 WEEKS WATER DISINFECTION MODEL (DICHLOROACETIC ACID) Date: 12/05/03 Route: SKIN APPLICATION Time: 09:26:33 ____________________________________________________________________________________________________________________________________ TGAC (FVB/N) HEMIZYGOUS FEMALE 0 MG/KG 31.25 125MG/KG 500MG/KG MG/KG ____________________________________________________________________________________________________________________________________ DISPOSITION SUMMARY Animals Initially in Study 10 10 10 10 Early Deaths Moribund Sacrifice 2 3 2 2 Natural Death 2 2 Survivors Terminal Sacrifice 8 5 6 8 Animals Examined Microscopically 10 10 10 10 ____________________________________________________________________________________________________________________________________ ALIMENTARY SYSTEM Liver (10) (10) (10) (10) Histiocytic Sarcoma 1 (10%) Salivary Glands (1) (1) Carcinoma 1 (100%) 1 (100%) Stomach, Forestomach (10) (10) (10) (10) Squamous Cell Papilloma 2 (20%) 3 (30%) 1 (10%) Squamous Cell Papilloma, Multiple 4 (40%) 5 (50%) 5 (50%) 6 (60%) Tooth (4) (2) (3) (3) Odontogenic Tumor 4 (100%) 2 (100%) 3 (100%) 1 (33%) Odontogenic Tumor, Multiple 1 (33%) ____________________________________________________________________________________________________________________________________ CARDIOVASCULAR SYSTEM None ____________________________________________________________________________________________________________________________________ ENDOCRINE SYSTEM Adrenal Cortex (10) (10) (10) (10) Adrenal Medulla (10) (10) (10) (10) Pituitary Gland (10) (10) (9) (10) ____________________________________________________________________________________________________________________________________ GENERAL BODY SYSTEM None ____________________________________________________________________________________________________________________________________ Page 2 NTP Experiment-Test: 97013-89 INCIDENCE RATES OF NEOPLASMS BY ANATOMIC SITE (SYSTEMIC LESIONS ABRIDGED) (a) Report: PEIRPT05 Study Type: 26-39 WEEKS WATER DISINFECTION MODEL (DICHLOROACETIC ACID) Date: 12/05/03 Route: SKIN APPLICATION Time: 09:26:33 ____________________________________________________________________________________________________________________________________ TGAC (FVB/N) HEMIZYGOUS FEMALE 0 MG/KG 31.25 125MG/KG 500MG/KG MG/KG ____________________________________________________________________________________________________________________________________ GENITAL SYSTEM Ovary (10) (10) (10) (10) Histiocytic Sarcoma 1 (10%) Uterus (10) (10) (10) (10) Histiocytic Sarcoma 1 (10%) ____________________________________________________________________________________________________________________________________ HEMATOPOIETIC SYSTEM Lymph Node, Mandibular (10) (9) (10) (10) Histiocytic Sarcoma 1 (10%) Lymph Node, Mesenteric (10) (10) (10) (10) Histiocytic Sarcoma 1 (10%) Spleen (10) (10) (10) (10) Histiocytic Sarcoma 1 (10%) ____________________________________________________________________________________________________________________________________ INTEGUMENTARY SYSTEM Skin (10) (10) (10) (10) Squamous Cell Carcinoma 1 (10%) Squamous Cell Papilloma 2 (20%) 3 (30%) 1 (10%) 3 (30%) Squamous Cell Papilloma, Multiple 5 (50%) 2 (20%) 4 (40%) 4 (40%) Site of Application, Squamous Cell Papilloma 3 (30%) Site of Application, Squamous Cell Papilloma, Multiple 3 (30%) ____________________________________________________________________________________________________________________________________ MUSCULOSKELETAL SYSTEM None ____________________________________________________________________________________________________________________________________ NERVOUS SYSTEM None ____________________________________________________________________________________________________________________________________ Page 3 NTP Experiment-Test: 97013-89 INCIDENCE RATES OF NEOPLASMS BY ANATOMIC SITE (SYSTEMIC LESIONS ABRIDGED) (a) Report: PEIRPT05 Study Type: 26-39 WEEKS WATER DISINFECTION MODEL (DICHLOROACETIC ACID) Date: 12/05/03 Route: SKIN APPLICATION Time: 09:26:33 ____________________________________________________________________________________________________________________________________ TGAC (FVB/N) HEMIZYGOUS FEMALE 0 MG/KG 31.25 125MG/KG 500MG/KG MG/KG ____________________________________________________________________________________________________________________________________ RESPIRATORY SYSTEM Lung (10) (10) (10) (10) Alveolar/Bronchiolar Adenoma 1 (10%) 2 (20%) ____________________________________________________________________________________________________________________________________ SPECIAL SENSES SYSTEM None ____________________________________________________________________________________________________________________________________ URINARY SYSTEM Kidney (10) (10) (10) (10) Histiocytic Sarcoma 1 (10%) ____________________________________________________________________________________________________________________________________ SYSTEMIC LESIONS Multiple Organs *(10) *(10) *(10) *(10) Histiocytic Sarcoma 1 (10%) Lymphoma Malignant 1 (10%) ____________________________________________________________________________________________________________________________________ * Number of animals with any tissue examined microscopically Page 4 NTP Experiment-Test: 97013-89 INCIDENCE RATES OF NEOPLASMS BY ANATOMIC SITE (SYSTEMIC LESIONS ABRIDGED) (a) Report: PEIRPT05 Study Type: 26-39 WEEKS WATER DISINFECTION MODEL (DICHLOROACETIC ACID) Date: 12/05/03 Route: SKIN APPLICATION Time: 09:26:33 ____________________________________________________________________________________________________________________________________ TGAC (FVB/N) HEMIZYGOUS FEMALE 0 MG/KG 31.25 125MG/KG 500MG/KG MG/KG ____________________________________________________________________________________________________________________________________ TUMOR SUMMARY Total Animals with Primary Neoplasms (b) 10 8 9 9 Total Primary Neoplasms 19 16 16 24 Total Animals with Benign Neoplasms 8 8 6 9 Total Benign Neoplasms 13 13 11 22 Total Animals with Malignant Neoplasms 2 1 2 Total Malignant Neoplasms 2 1 2 Total Animals with Metastatic Neoplasms Total Metastatic Neoplasm Total Animals with Malignant Neoplasms Uncertain Primary Site Total Animals with Neoplasms Uncertain- Benign or Malignant 4 2 3 2 Total Uncertain Neoplasms 4 2 3 2 ____________________________________________________________________________________________________________________________________ a Number of animals examined microscopically at site and number of animals with lesion b Primary tumors: all tumors except metastatic tumors Page 5 NTP Experiment-Test: 97013-89 INCIDENCE RATES OF NEOPLASMS BY ANATOMIC SITE (SYSTEMIC LESIONS ABRIDGED) (a) Report: PEIRPT05 Study Type: 26-39 WEEKS WATER DISINFECTION MODEL (DICHLOROACETIC ACID) Date: 12/05/03 Route: SKIN APPLICATION Time: 09:26:33 ____________________________________________________________________________________________________________________________________ TGAC (FVB/N) HEMIZYGOUS MALE 0 MG/KG 31.25 125MG/KG 500MG/KG MG/KG ____________________________________________________________________________________________________________________________________ DISPOSITION SUMMARY Animals Initially in Study 10 10 10 10 Early Deaths Moribund Sacrifice 1 3 1 2 Natural Death 1 1 1 Survivors Terminal Sacrifice 9 6 8 7 Animals Examined Microscopically 10 10 10 10 ____________________________________________________________________________________________________________________________________ ALIMENTARY SYSTEM Liver (10) (10) (10) (10) Pancreas (1) Stomach, Forestomach (10) (10) (10) (10) Squamous Cell Papilloma 2 (20%) 2 (20%) 4 (40%) Squamous Cell Papilloma, Multiple 5 (50%) 4 (40%) 8 (80%) 3 (30%) Tooth (1) (4) (2) (2) Odontogenic Tumor 1 (100%) 4 (100%) 2 (100%) 1 (50%) Odontogenic Tumor, Multiple 1 (50%) ____________________________________________________________________________________________________________________________________ CARDIOVASCULAR SYSTEM None ____________________________________________________________________________________________________________________________________ ENDOCRINE SYSTEM None ____________________________________________________________________________________________________________________________________ GENERAL BODY SYSTEM None ____________________________________________________________________________________________________________________________________ Page 6 NTP Experiment-Test: 97013-89 INCIDENCE RATES OF NEOPLASMS BY ANATOMIC SITE (SYSTEMIC LESIONS ABRIDGED) (a) Report: PEIRPT05 Study Type: 26-39 WEEKS WATER DISINFECTION MODEL (DICHLOROACETIC ACID) Date: 12/05/03 Route: SKIN APPLICATION Time: 09:26:33 ____________________________________________________________________________________________________________________________________ TGAC (FVB/N) HEMIZYGOUS MALE 0 MG/KG 31.25 125MG/KG 500MG/KG MG/KG ____________________________________________________________________________________________________________________________________ GENITAL SYSTEM None ____________________________________________________________________________________________________________________________________ HEMATOPOIETIC SYSTEM Lymph Node (1) (1) Lymph Node, Mandibular (10) (10) (10) (10) Lymph Node, Mesenteric (10) (10) (10) (10) Spleen (10) (10) (10) (10) Thymus (9) (10) (10) (9) ____________________________________________________________________________________________________________________________________ INTEGUMENTARY SYSTEM Skin (10) (10) (10) (10) Squamous Cell Papilloma 2 (20%) 7 (70%) Squamous Cell Papilloma, Multiple 6 (60%) 4 (40%) 7 (70%) 2 (20%) Site of Application, Squamous Cell Papilloma 1 (10%) 2 (20%) Site of Application, Squamous Cell Papilloma, Multiple 1 (10%) 6 (60%) ____________________________________________________________________________________________________________________________________ MUSCULOSKELETAL SYSTEM None ____________________________________________________________________________________________________________________________________ NERVOUS SYSTEM None ____________________________________________________________________________________________________________________________________ RESPIRATORY SYSTEM Lung (10) (10) (10) (10) Alveolar/Bronchiolar Adenoma 1 (10%) 2 (20%) Nose (1) Glands, Carcinoma 1 (100%) ____________________________________________________________________________________________________________________________________ Page 7 NTP Experiment-Test: 97013-89 INCIDENCE RATES OF NEOPLASMS BY ANATOMIC SITE (SYSTEMIC LESIONS ABRIDGED) (a) Report: PEIRPT05 Study Type: 26-39 WEEKS WATER DISINFECTION MODEL (DICHLOROACETIC ACID) Date: 12/05/03 Route: SKIN APPLICATION Time: 09:26:33 ____________________________________________________________________________________________________________________________________ TGAC (FVB/N) HEMIZYGOUS MALE 0 MG/KG 31.25 125MG/KG 500MG/KG MG/KG ____________________________________________________________________________________________________________________________________ SPECIAL SENSES SYSTEM None ____________________________________________________________________________________________________________________________________ URINARY SYSTEM Kidney (10) (10) (10) (10) ____________________________________________________________________________________________________________________________________ SYSTEMIC LESIONS Multiple Organs *(10) *(10) *(10) *(10) Leukemia Erythrocytic 1 (10%) Lymphoma Malignant 1 (10%) ____________________________________________________________________________________________________________________________________ * Number of animals with any tissue examined microscopically Page 8 NTP Experiment-Test: 97013-89 INCIDENCE RATES OF NEOPLASMS BY ANATOMIC SITE (SYSTEMIC LESIONS ABRIDGED) (a) Report: PEIRPT05 Study Type: 26-39 WEEKS WATER DISINFECTION MODEL (DICHLOROACETIC ACID) Date: 12/05/03 Route: SKIN APPLICATION Time: 09:26:33 ____________________________________________________________________________________________________________________________________ TGAC (FVB/N) HEMIZYGOUS MALE 0 MG/KG 31.25 125MG/KG 500MG/KG MG/KG ____________________________________________________________________________________________________________________________________ TUMOR SUMMARY Total Animals with Primary Neoplasms (b) 10 10 9 10 Total Primary Neoplasms 17 15 20 29 Total Animals with Benign Neoplasms 10 7 9 10 Total Benign Neoplasms 15 10 18 26 Total Animals with Malignant Neoplasms 1 1 1 Total Malignant Neoplasms 1 1 1 Total Animals with Metastatic Neoplasms Total Metastatic Neoplasm Total Animals with Malignant Neoplasms Uncertain Primary Site Total Animals with Neoplasms Uncertain- Benign or Malignant 1 4 2 2 Total Uncertain Neoplasms 1 4 2 2 ____________________________________________________________________________________________________________________________________ a Number of animals examined microscopically at site and number of animals with lesion b Primary tumors: all tumors except metastatic tumors Page 9 ------------------------------------------------------------ ---------- END OF REPORT ---------- ------------------------------------------------------------