TDMS Study 97013-89 Pathology Tables
NTP Experiment-Test: 97013-89 INCIDENCE RATES OF NEOPLASMS BY ANATOMIC SITE (SYSTEMIC LESIONS ABRIDGED) (a) Report: PEIRPT05
Study Type: 26-39 WEEKS WATER DISINFECTION MODEL (DICHLOROACETIC ACID) Date: 12/05/03
Route: SKIN APPLICATION Time: 09:26:33
FINAL#1 MICE
Facility: Battelle Columbus Laboratory
Chemical CAS #: 79-43-6
Lock Date: 07/31/01
Cage Range: All
Reasons For Removal: All
Removal Date Range: All
Treatment Groups: Include All
a Number of animals examined microscopically at site and number of animals with lesion
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NTP Experiment-Test: 97013-89 INCIDENCE RATES OF NEOPLASMS BY ANATOMIC SITE (SYSTEMIC LESIONS ABRIDGED) (a) Report: PEIRPT05
Study Type: 26-39 WEEKS WATER DISINFECTION MODEL (DICHLOROACETIC ACID) Date: 12/05/03
Route: SKIN APPLICATION Time: 09:26:33
____________________________________________________________________________________________________________________________________
TGAC (FVB/N) HEMIZYGOUS FEMALE 0 MG/KG 31.25 125MG/KG 500MG/KG
MG/KG
____________________________________________________________________________________________________________________________________
DISPOSITION SUMMARY
Animals Initially in Study 10 10 10 10
Early Deaths
Moribund Sacrifice 2 3 2 2
Natural Death 2 2
Survivors
Terminal Sacrifice 8 5 6 8
Animals Examined Microscopically 10 10 10 10
____________________________________________________________________________________________________________________________________
ALIMENTARY SYSTEM
Liver (10) (10) (10) (10)
Histiocytic Sarcoma 1 (10%)
Salivary Glands (1) (1)
Carcinoma 1 (100%) 1 (100%)
Stomach, Forestomach (10) (10) (10) (10)
Squamous Cell Papilloma 2 (20%) 3 (30%) 1 (10%)
Squamous Cell Papilloma, Multiple 4 (40%) 5 (50%) 5 (50%) 6 (60%)
Tooth (4) (2) (3) (3)
Odontogenic Tumor 4 (100%) 2 (100%) 3 (100%) 1 (33%)
Odontogenic Tumor, Multiple 1 (33%)
____________________________________________________________________________________________________________________________________
CARDIOVASCULAR SYSTEM
None
____________________________________________________________________________________________________________________________________
ENDOCRINE SYSTEM
Adrenal Cortex (10) (10) (10) (10)
Adrenal Medulla (10) (10) (10) (10)
Pituitary Gland (10) (10) (9) (10)
____________________________________________________________________________________________________________________________________
GENERAL BODY SYSTEM
None
____________________________________________________________________________________________________________________________________
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NTP Experiment-Test: 97013-89 INCIDENCE RATES OF NEOPLASMS BY ANATOMIC SITE (SYSTEMIC LESIONS ABRIDGED) (a) Report: PEIRPT05
Study Type: 26-39 WEEKS WATER DISINFECTION MODEL (DICHLOROACETIC ACID) Date: 12/05/03
Route: SKIN APPLICATION Time: 09:26:33
____________________________________________________________________________________________________________________________________
TGAC (FVB/N) HEMIZYGOUS FEMALE 0 MG/KG 31.25 125MG/KG 500MG/KG
MG/KG
____________________________________________________________________________________________________________________________________
GENITAL SYSTEM
Ovary (10) (10) (10) (10)
Histiocytic Sarcoma 1 (10%)
Uterus (10) (10) (10) (10)
Histiocytic Sarcoma 1 (10%)
____________________________________________________________________________________________________________________________________
HEMATOPOIETIC SYSTEM
Lymph Node, Mandibular (10) (9) (10) (10)
Histiocytic Sarcoma 1 (10%)
Lymph Node, Mesenteric (10) (10) (10) (10)
Histiocytic Sarcoma 1 (10%)
Spleen (10) (10) (10) (10)
Histiocytic Sarcoma 1 (10%)
____________________________________________________________________________________________________________________________________
INTEGUMENTARY SYSTEM
Skin (10) (10) (10) (10)
Squamous Cell Carcinoma 1 (10%)
Squamous Cell Papilloma 2 (20%) 3 (30%) 1 (10%) 3 (30%)
Squamous Cell Papilloma, Multiple 5 (50%) 2 (20%) 4 (40%) 4 (40%)
Site of Application, Squamous Cell Papilloma 3 (30%)
Site of Application, Squamous Cell Papilloma,
Multiple 3 (30%)
____________________________________________________________________________________________________________________________________
MUSCULOSKELETAL SYSTEM
None
____________________________________________________________________________________________________________________________________
NERVOUS SYSTEM
None
____________________________________________________________________________________________________________________________________
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NTP Experiment-Test: 97013-89 INCIDENCE RATES OF NEOPLASMS BY ANATOMIC SITE (SYSTEMIC LESIONS ABRIDGED) (a) Report: PEIRPT05
Study Type: 26-39 WEEKS WATER DISINFECTION MODEL (DICHLOROACETIC ACID) Date: 12/05/03
Route: SKIN APPLICATION Time: 09:26:33
____________________________________________________________________________________________________________________________________
TGAC (FVB/N) HEMIZYGOUS FEMALE 0 MG/KG 31.25 125MG/KG 500MG/KG
MG/KG
____________________________________________________________________________________________________________________________________
RESPIRATORY SYSTEM
Lung (10) (10) (10) (10)
Alveolar/Bronchiolar Adenoma 1 (10%) 2 (20%)
____________________________________________________________________________________________________________________________________
SPECIAL SENSES SYSTEM
None
____________________________________________________________________________________________________________________________________
URINARY SYSTEM
Kidney (10) (10) (10) (10)
Histiocytic Sarcoma 1 (10%)
____________________________________________________________________________________________________________________________________
SYSTEMIC LESIONS
Multiple Organs *(10) *(10) *(10) *(10)
Histiocytic Sarcoma 1 (10%)
Lymphoma Malignant 1 (10%)
____________________________________________________________________________________________________________________________________
* Number of animals with any tissue examined microscopically
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NTP Experiment-Test: 97013-89 INCIDENCE RATES OF NEOPLASMS BY ANATOMIC SITE (SYSTEMIC LESIONS ABRIDGED) (a) Report: PEIRPT05
Study Type: 26-39 WEEKS WATER DISINFECTION MODEL (DICHLOROACETIC ACID) Date: 12/05/03
Route: SKIN APPLICATION Time: 09:26:33
____________________________________________________________________________________________________________________________________
TGAC (FVB/N) HEMIZYGOUS FEMALE 0 MG/KG 31.25 125MG/KG 500MG/KG
MG/KG
____________________________________________________________________________________________________________________________________
TUMOR SUMMARY
Total Animals with Primary Neoplasms (b) 10 8 9 9
Total Primary Neoplasms 19 16 16 24
Total Animals with Benign Neoplasms 8 8 6 9
Total Benign Neoplasms 13 13 11 22
Total Animals with Malignant Neoplasms 2 1 2
Total Malignant Neoplasms 2 1 2
Total Animals with Metastatic Neoplasms
Total Metastatic Neoplasm
Total Animals with Malignant Neoplasms
Uncertain Primary Site
Total Animals with Neoplasms Uncertain-
Benign or Malignant 4 2 3 2
Total Uncertain Neoplasms 4 2 3 2
____________________________________________________________________________________________________________________________________
a Number of animals examined microscopically at site and number of animals with lesion
b Primary tumors: all tumors except metastatic tumors
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NTP Experiment-Test: 97013-89 INCIDENCE RATES OF NEOPLASMS BY ANATOMIC SITE (SYSTEMIC LESIONS ABRIDGED) (a) Report: PEIRPT05
Study Type: 26-39 WEEKS WATER DISINFECTION MODEL (DICHLOROACETIC ACID) Date: 12/05/03
Route: SKIN APPLICATION Time: 09:26:33
____________________________________________________________________________________________________________________________________
TGAC (FVB/N) HEMIZYGOUS MALE 0 MG/KG 31.25 125MG/KG 500MG/KG
MG/KG
____________________________________________________________________________________________________________________________________
DISPOSITION SUMMARY
Animals Initially in Study 10 10 10 10
Early Deaths
Moribund Sacrifice 1 3 1 2
Natural Death 1 1 1
Survivors
Terminal Sacrifice 9 6 8 7
Animals Examined Microscopically 10 10 10 10
____________________________________________________________________________________________________________________________________
ALIMENTARY SYSTEM
Liver (10) (10) (10) (10)
Pancreas (1)
Stomach, Forestomach (10) (10) (10) (10)
Squamous Cell Papilloma 2 (20%) 2 (20%) 4 (40%)
Squamous Cell Papilloma, Multiple 5 (50%) 4 (40%) 8 (80%) 3 (30%)
Tooth (1) (4) (2) (2)
Odontogenic Tumor 1 (100%) 4 (100%) 2 (100%) 1 (50%)
Odontogenic Tumor, Multiple 1 (50%)
____________________________________________________________________________________________________________________________________
CARDIOVASCULAR SYSTEM
None
____________________________________________________________________________________________________________________________________
ENDOCRINE SYSTEM
None
____________________________________________________________________________________________________________________________________
GENERAL BODY SYSTEM
None
____________________________________________________________________________________________________________________________________
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NTP Experiment-Test: 97013-89 INCIDENCE RATES OF NEOPLASMS BY ANATOMIC SITE (SYSTEMIC LESIONS ABRIDGED) (a) Report: PEIRPT05
Study Type: 26-39 WEEKS WATER DISINFECTION MODEL (DICHLOROACETIC ACID) Date: 12/05/03
Route: SKIN APPLICATION Time: 09:26:33
____________________________________________________________________________________________________________________________________
TGAC (FVB/N) HEMIZYGOUS MALE 0 MG/KG 31.25 125MG/KG 500MG/KG
MG/KG
____________________________________________________________________________________________________________________________________
GENITAL SYSTEM
None
____________________________________________________________________________________________________________________________________
HEMATOPOIETIC SYSTEM
Lymph Node (1) (1)
Lymph Node, Mandibular (10) (10) (10) (10)
Lymph Node, Mesenteric (10) (10) (10) (10)
Spleen (10) (10) (10) (10)
Thymus (9) (10) (10) (9)
____________________________________________________________________________________________________________________________________
INTEGUMENTARY SYSTEM
Skin (10) (10) (10) (10)
Squamous Cell Papilloma 2 (20%) 7 (70%)
Squamous Cell Papilloma, Multiple 6 (60%) 4 (40%) 7 (70%) 2 (20%)
Site of Application, Squamous Cell Papilloma 1 (10%) 2 (20%)
Site of Application, Squamous Cell Papilloma,
Multiple 1 (10%) 6 (60%)
____________________________________________________________________________________________________________________________________
MUSCULOSKELETAL SYSTEM
None
____________________________________________________________________________________________________________________________________
NERVOUS SYSTEM
None
____________________________________________________________________________________________________________________________________
RESPIRATORY SYSTEM
Lung (10) (10) (10) (10)
Alveolar/Bronchiolar Adenoma 1 (10%) 2 (20%)
Nose (1)
Glands, Carcinoma 1 (100%)
____________________________________________________________________________________________________________________________________
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NTP Experiment-Test: 97013-89 INCIDENCE RATES OF NEOPLASMS BY ANATOMIC SITE (SYSTEMIC LESIONS ABRIDGED) (a) Report: PEIRPT05
Study Type: 26-39 WEEKS WATER DISINFECTION MODEL (DICHLOROACETIC ACID) Date: 12/05/03
Route: SKIN APPLICATION Time: 09:26:33
____________________________________________________________________________________________________________________________________
TGAC (FVB/N) HEMIZYGOUS MALE 0 MG/KG 31.25 125MG/KG 500MG/KG
MG/KG
____________________________________________________________________________________________________________________________________
SPECIAL SENSES SYSTEM
None
____________________________________________________________________________________________________________________________________
URINARY SYSTEM
Kidney (10) (10) (10) (10)
____________________________________________________________________________________________________________________________________
SYSTEMIC LESIONS
Multiple Organs *(10) *(10) *(10) *(10)
Leukemia Erythrocytic 1 (10%)
Lymphoma Malignant 1 (10%)
____________________________________________________________________________________________________________________________________
* Number of animals with any tissue examined microscopically
Page 8
NTP Experiment-Test: 97013-89 INCIDENCE RATES OF NEOPLASMS BY ANATOMIC SITE (SYSTEMIC LESIONS ABRIDGED) (a) Report: PEIRPT05
Study Type: 26-39 WEEKS WATER DISINFECTION MODEL (DICHLOROACETIC ACID) Date: 12/05/03
Route: SKIN APPLICATION Time: 09:26:33
____________________________________________________________________________________________________________________________________
TGAC (FVB/N) HEMIZYGOUS MALE 0 MG/KG 31.25 125MG/KG 500MG/KG
MG/KG
____________________________________________________________________________________________________________________________________
TUMOR SUMMARY
Total Animals with Primary Neoplasms (b) 10 10 9 10
Total Primary Neoplasms 17 15 20 29
Total Animals with Benign Neoplasms 10 7 9 10
Total Benign Neoplasms 15 10 18 26
Total Animals with Malignant Neoplasms 1 1 1
Total Malignant Neoplasms 1 1 1
Total Animals with Metastatic Neoplasms
Total Metastatic Neoplasm
Total Animals with Malignant Neoplasms
Uncertain Primary Site
Total Animals with Neoplasms Uncertain-
Benign or Malignant 1 4 2 2
Total Uncertain Neoplasms 1 4 2 2
____________________________________________________________________________________________________________________________________
a Number of animals examined microscopically at site and number of animals with lesion
b Primary tumors: all tumors except metastatic tumors
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