TDMS Study 97013-89 Pathology Tables
NTP Experiment-Test: 97013-89 INCIDENCE RATES OF NONNEOPLASTIC LESIONS BY ANATOMIC SITE (a) Report: PEIRPT18
Study Type: 26-39 WEEKS WITH AVERAGE SEVERITY GRADES[b] Date: 12/05/03
Route: SKIN APPLICATION WATER DISINFECTION MODEL (DICHLOROACETIC ACID) Time: 09:30:34
FINAL#1 MICE
Facility: Battelle Columbus Laboratory
Chemical CAS #: 79-43-6
Lock Date: 07/31/01
Cage Range: All
Reasons For Removal: All
Removal Date Range: All
Treatment Groups: Include All
a Number of animals examined microscopically at site and number of animals with lesion
b Average severity grade (1-minimal;2-mild;3-moderate;4-marked)
Page 1
NTP Experiment-Test: 97013-89 INCIDENCE RATES OF NONNEOPLASTIC LESIONS BY ANATOMIC SITE (a) Report: PEIRPT18
Study Type: 26-39 WEEKS WITH AVERAGE SEVERITY GRADES[b] Date: 12/05/03
Route: SKIN APPLICATION WATER DISINFECTION MODEL (DICHLOROACETIC ACID) Time: 09:30:34
____________________________________________________________________________________________________________________________________
TGAC (FVB/N) HEMIZYGOUS FEMALE 0 MG/KG 31.25 125MG/KG 500MG/KG
MG/KG
____________________________________________________________________________________________________________________________________
DISPOSITION SUMMARY
Animals Initially In Study 10 10 10 10
Early Deaths
Moribund Sacrifice 2 3 2 2
Natural Death 2 2
Survivors
Terminal Sacrifice 8 5 6 8
Animals Examined Microscopically 10 10 10 10
____________________________________________________________________________________________________________________________________
ALIMENTARY SYSTEM
Liver (10) (10) (10) (10)
Inflammation, Chronic Active 9 [1.1] 9 [1.0] 8 [1.0] 10 [1.1]
Hepatocyte, Necrosis 2 [1.0] 1 [1.0] 5 [1.2]
Hepatocyte, Vacuolization Cytoplasmic 7 [1.0] 6 [1.2] 8 [2.0] 10 [2.7]
Salivary Glands (1) (1)
Degeneration 1 [3.0]
Tooth (4) (2) (3) (3)
Inflammation, Chronic 1 [3.0]
____________________________________________________________________________________________________________________________________
CARDIOVASCULAR SYSTEM
None
____________________________________________________________________________________________________________________________________
ENDOCRINE SYSTEM
Adrenal Cortex (10) (10) (10) (10)
Accessory Adrenal Cortical Nodule 3 [1.7] 2 [1.5]
Mineralization 3 [1.0] 1 [1.0] 2 [1.0]
Subcapsular, Hyperplasia 7 [1.0] 6 [1.0] 8 [1.0] 5 [1.0]
Pituitary Gland (10) (10) (9) (10)
Pars Distalis, Cyst 1 [2.0] 2 [1.5] 2 [1.0]
Thyroid Gland (10) (10) (10) (10)
Follicle, Degeneration 2 [1.5] 6 [1.2] 2 [1.0]
____________________________________________________________________________________________________________________________________
GENERAL BODY SYSTEM
None
a Number of animals examined microscopically at site and number of animals with lesion
b Average severity grade (1-minimal;2-mild;3-moderate;4-marked)
Page 2
NTP Experiment-Test: 97013-89 INCIDENCE RATES OF NONNEOPLASTIC LESIONS BY ANATOMIC SITE (a) Report: PEIRPT18
Study Type: 26-39 WEEKS WITH AVERAGE SEVERITY GRADES[b] Date: 12/05/03
Route: SKIN APPLICATION WATER DISINFECTION MODEL (DICHLOROACETIC ACID) Time: 09:30:34
____________________________________________________________________________________________________________________________________
TGAC (FVB/N) HEMIZYGOUS FEMALE 0 MG/KG 31.25 125MG/KG 500MG/KG
MG/KG
____________________________________________________________________________________________________________________________________
GENITAL SYSTEM
Ovary (10) (10) (10) (10)
Cyst 2 [2.5] 1 [2.0] 1 [2.0] 2 [1.5]
Uterus (10) (10) (10) (10)
Inflammation, Chronic Active 1 [1.0]
Endometrium, Hyperplasia, Cystic 9 [1.9] 8 [2.1] 8 [1.6] 8 [1.8]
____________________________________________________________________________________________________________________________________
HEMATOPOIETIC SYSTEM
Lymph Node, Mandibular (10) (9) (10) (10)
Hyperplasia, Lymphoid 2 [3.0] 3 [3.0] 3 [3.0] 2 [2.0]
Spleen (10) (10) (10) (10)
Hematopoietic Cell Proliferation 1 [2.0]
Thymus (10) (10) (9) (10)
Atrophy 3 [2.7] 3 [3.0] 2 [2.5] 1 [2.0]
Cyst 5 [1.0] 2 [2.0] 2 [1.0] 3 [1.3]
Thymocyte, Necrosis 1 [4.0]
____________________________________________________________________________________________________________________________________
INTEGUMENTARY SYSTEM
Skin (10) (10) (10) (10)
Fibrosis 1 [3.0]
Hyperkeratosis 1 [4.0]
Inflammation, Chronic Active 3 [3.0]
Ulcer 2 [4.0]
Epidermis, Hyperplasia, Focal 1 [3.0] 2 [2.0]
Site of Application - Epidermis,
Hyperkeratosis 5 [1.4] 8 [1.0] 9 [1.4] 10 [1.0]
Site of Application - Epidermis, Hyperplasia 3 [1.3] 6 [1.3]
Site of Application - Epidermis,
Inflammation, Chronic Active 1 [2.0]
____________________________________________________________________________________________________________________________________
MUSCULOSKELETAL SYSTEM
None
____________________________________________________________________________________________________________________________________
NERVOUS SYSTEM
a Number of animals examined microscopically at site and number of animals with lesion
b Average severity grade (1-minimal;2-mild;3-moderate;4-marked)
Page 3
NTP Experiment-Test: 97013-89 INCIDENCE RATES OF NONNEOPLASTIC LESIONS BY ANATOMIC SITE (a) Report: PEIRPT18
Study Type: 26-39 WEEKS WITH AVERAGE SEVERITY GRADES[b] Date: 12/05/03
Route: SKIN APPLICATION WATER DISINFECTION MODEL (DICHLOROACETIC ACID) Time: 09:30:34
____________________________________________________________________________________________________________________________________
TGAC (FVB/N) HEMIZYGOUS FEMALE 0 MG/KG 31.25 125MG/KG 500MG/KG
MG/KG
____________________________________________________________________________________________________________________________________
NERVOUS SYSTEM - CONT
Spinal Cord (1)
Necrosis 1 [4.0]
____________________________________________________________________________________________________________________________________
RESPIRATORY SYSTEM
Lung (10) (10) (10) (10)
Inflammation, Chronic Active 2 [1.5]
Alveolar Epithelium, Hyperplasia 1 [1.0]
____________________________________________________________________________________________________________________________________
SPECIAL SENSES SYSTEM
None
____________________________________________________________________________________________________________________________________
URINARY SYSTEM
Kidney (10) (10) (10) (10)
Nephropathy 4 [1.5] 2 [1.0] 3 [1.0] 2 [1.0]
Glomerulus, Inflammation,
Membranoproliferative 1 [3.0]
Renal Tubule, Dilatation 1 [2.0] 2 [1.5] 1 [1.0] 1 [1.0]
a Number of animals examined microscopically at site and number of animals with lesion
b Average severity grade (1-minimal;2-mild;3-moderate;4-marked)
Page 4
NTP Experiment-Test: 97013-89 INCIDENCE RATES OF NONNEOPLASTIC LESIONS BY ANATOMIC SITE (a) Report: PEIRPT18
Study Type: 26-39 WEEKS WITH AVERAGE SEVERITY GRADES[b] Date: 12/05/03
Route: SKIN APPLICATION WATER DISINFECTION MODEL (DICHLOROACETIC ACID) Time: 09:30:34
____________________________________________________________________________________________________________________________________
TGAC (FVB/N) HEMIZYGOUS MALE 0 MG/KG 31.25 125MG/KG 500MG/KG
MG/KG
____________________________________________________________________________________________________________________________________
DISPOSITION SUMMARY
Animals Initially In Study 10 10 10 10
Early Deaths
Moribund Sacrifice 1 3 1 2
Natural Death 1 1 1
Survivors
Terminal Sacrifice 9 6 8 7
Animals Examined Microscopically 10 10 10 10
____________________________________________________________________________________________________________________________________
ALIMENTARY SYSTEM
Liver (10) (10) (10) (10)
Cyst 1
Inflammation, Chronic Active 6 [1.0] 7 [1.1] 5 [1.0] 5 [1.0]
Mineralization 1 [1.0]
Hepatocyte, Necrosis 1 [1.0] 2 [1.0] 6 [1.0]
Hepatocyte, Vacuolization Cytoplasmic 9 [1.1] 7 [1.3] 8 [2.3] 10 [3.0]
Mesentery (1) (2)
Fat, Fibrosis 2 [2.0]
Fat, Mineralization 1 [1.0] 1 [1.0]
Fat, Necrosis 1 [4.0] 2 [4.0]
Salivary Glands (1) (1)
Atrophy 1 [3.0] 1 [2.0]
Stomach, Forestomach (10) (10) (10) (10)
Epithelium, Hyperkeratosis 1 [3.0]
Epithelium, Hyperplasia 1 [2.0]
____________________________________________________________________________________________________________________________________
CARDIOVASCULAR SYSTEM
None
____________________________________________________________________________________________________________________________________
ENDOCRINE SYSTEM
Adrenal Cortex (10) (10) (10) (10)
Accessory Adrenal Cortical Nodule 1 [2.0]
Hypertrophy 8 [1.9] 8 [1.9] 6 [2.0] 7 [1.3]
Subcapsular, Hyperplasia 1 [1.0] 1 [1.0] 1 [1.0]
Pituitary Gland (9) (10) (9) (10)
Pars Distalis, Cyst 2 [1.0] 1 [1.0]
a Number of animals examined microscopically at site and number of animals with lesion
b Average severity grade (1-minimal;2-mild;3-moderate;4-marked)
Page 5
NTP Experiment-Test: 97013-89 INCIDENCE RATES OF NONNEOPLASTIC LESIONS BY ANATOMIC SITE (a) Report: PEIRPT18
Study Type: 26-39 WEEKS WITH AVERAGE SEVERITY GRADES[b] Date: 12/05/03
Route: SKIN APPLICATION WATER DISINFECTION MODEL (DICHLOROACETIC ACID) Time: 09:30:34
____________________________________________________________________________________________________________________________________
TGAC (FVB/N) HEMIZYGOUS MALE 0 MG/KG 31.25 125MG/KG 500MG/KG
MG/KG
____________________________________________________________________________________________________________________________________
ENDOCRINE SYSTEM - CONT
Thyroid Gland (10) (10) (10) (10)
Follicle, Degeneration 2 [1.0] 2 [1.0] 2 [1.0] 2 [1.5]
____________________________________________________________________________________________________________________________________
GENERAL BODY SYSTEM
None
____________________________________________________________________________________________________________________________________
GENITAL SYSTEM
Epididymis (10) (10) (10) (10)
Degeneration 3 [4.0] 2 [4.0] 1 [4.0] 1 [4.0]
Preputial Gland (1)
Duct, Ectasia 1 [2.0]
Testes (10) (10) (10) (10)
Cyst 3 [1.7] 1 [2.0] 1 [2.0]
Germinal Epithelium, Degeneration 3 [3.7] 2 [3.0] 1 [2.0] 8 [2.3]
____________________________________________________________________________________________________________________________________
HEMATOPOIETIC SYSTEM
Lymph Node, Mandibular (10) (10) (10) (10)
Hyperplasia, Lymphoid 3 [3.3] 1 [3.0] 1 [3.0]
Spleen (10) (10) (10) (10)
Hematopoietic Cell Proliferation 1 [2.0]
Thymus (9) (10) (10) (9)
Atrophy 3 [2.7] 1 [3.0] 4 [2.8]
Cyst 3 [1.0] 4 [1.3] 2 [1.5] 3 [1.7]
Thymocyte, Necrosis 1 [4.0] 1 [4.0]
____________________________________________________________________________________________________________________________________
INTEGUMENTARY SYSTEM
Skin (10) (10) (10) (10)
Cyst Epithelial Inclusion 1 [3.0]
Hyperplasia 1 [3.0] 1 [4.0]
Inflammation, Chronic Active 2 [2.0]
Epidermis, Hyperplasia, Focal 3 [2.0] 1 [2.0]
Sebaceous Gland, Cyst 1 [2.0]
Site of Application - Dermis, Inflammation,
Chronic Active 1 [2.0]
Site of Application - Epidermis,
a Number of animals examined microscopically at site and number of animals with lesion
b Average severity grade (1-minimal;2-mild;3-moderate;4-marked)
Page 6
NTP Experiment-Test: 97013-89 INCIDENCE RATES OF NONNEOPLASTIC LESIONS BY ANATOMIC SITE (a) Report: PEIRPT18
Study Type: 26-39 WEEKS WITH AVERAGE SEVERITY GRADES[b] Date: 12/05/03
Route: SKIN APPLICATION WATER DISINFECTION MODEL (DICHLOROACETIC ACID) Time: 09:30:34
____________________________________________________________________________________________________________________________________
TGAC (FVB/N) HEMIZYGOUS MALE 0 MG/KG 31.25 125MG/KG 500MG/KG
MG/KG
____________________________________________________________________________________________________________________________________
INTEGUMENTARY SYSTEM - CONT
Hyperkeratosis 2 [1.0] 8 [1.3] 9 [1.6] 10 [2.1]
Site of Application - Epidermis, Hyperplasia 8 [1.3] 9 [2.2]
____________________________________________________________________________________________________________________________________
MUSCULOSKELETAL SYSTEM
None
____________________________________________________________________________________________________________________________________
NERVOUS SYSTEM
None
____________________________________________________________________________________________________________________________________
RESPIRATORY SYSTEM
Lung (10) (10) (10) (10)
Alveolar Epithelium, Hyperplasia 1 [4.0]
____________________________________________________________________________________________________________________________________
SPECIAL SENSES SYSTEM
None
____________________________________________________________________________________________________________________________________
URINARY SYSTEM
Kidney (10) (10) (10) (10)
Cyst 2 [2.5] 1 [4.0]
Infiltration Cellular, Plasma Cell 1 [2.0]
Mineralization 2 [1.0]
Nephropathy 2 [1.0] 7 [1.0] 7 [1.0] 8 [1.0]
Glomerulus, Inflammation,
Membranoproliferative 1 [2.0]
Renal Tubule, Dilatation 1 [2.0] 4 [1.5] 4 [1.8] 4 [1.5]
a Number of animals examined microscopically at site and number of animals with lesion
b Average severity grade (1-minimal;2-mild;3-moderate;4-marked)
Page 7
------------------------------------------------------------
---------- END OF REPORT ----------
------------------------------------------------------------