TDMS Study 97013-90 Pathology Tables
NTP Experiment-Test: 97013-90 INCIDENCE RATES OF NONNEOPLASTIC LESIONS BY ANATOMIC SITE (a) Report: PEIRPT03 Study Type: 26-39 WEEKS WATER DISINFECTION MODEL (DICHLOROACETIC ACID) Date: 12/05/03 Route: DOSED WATER Time: 09:33:35 FINAL #1 MICE Facility: Battelle Columbus Laboratory Chemical CAS #: 79-43-6 Lock Date: 07/31/01 Cage Range: All Reasons For Removal: All Removal Date Range: All Treatment Groups: Include All a Number of animals examined microscopically at site and number of animals with lesion Page 1 NTP Experiment-Test: 97013-90 INCIDENCE RATES OF NONNEOPLASTIC LESIONS BY ANATOMIC SITE (a) Report: PEIRPT03 Study Type: 26-39 WEEKS WATER DISINFECTION MODEL (DICHLOROACETIC ACID) Date: 12/05/03 Route: DOSED WATER Time: 09:33:35 ____________________________________________________________________________________________________________________________________ P53+/-(C57BL/6) FEMALE 0 MG/L 500 MG/L 1000MG/L 2000MG/L ____________________________________________________________________________________________________________________________________ DISPOSITION SUMMARY Animals Initially In Study 10 10 10 10 Early Deaths Moribund Sacrifice 1 Natural Death 1 Survivors Terminal Sacrifice 10 9 10 9 Animals Examined Microscopically 10 10 10 10 ____________________________________________________________________________________________________________________________________ ALIMENTARY SYSTEM Liver (10) (10) (10) (10) Inflammation, Chronic Active 10 (100%) 10 (100%) 10 (100%) 9 (90%) Hepatocyte, Fatty Change 1 (10%) Hepatocyte, Necrosis 1 (10%) Hepatocyte, Vacuolization Cytoplasmic 10 (100%) 10 (100%) 10 (100%) 10 (100%) ____________________________________________________________________________________________________________________________________ CARDIOVASCULAR SYSTEM None ____________________________________________________________________________________________________________________________________ ENDOCRINE SYSTEM Adrenal Cortex (10) (10) (10) (10) Accessory Adrenal Cortical Nodule 2 (20%) Subcapsular, Hyperplasia 10 (100%) 10 (100%) 9 (90%) 10 (100%) Pituitary Gland (10) (10) (10) (10) Pars Distalis, Cyst 1 (10%) 1 (10%) Pars Distalis, Hyperplasia 1 (10%) 1 (10%) Thyroid Gland (10) (10) (10) (10) Ectopic Thymus 1 (10%) Infiltration Cellular, Lymphocyte 2 (20%) ____________________________________________________________________________________________________________________________________ GENERAL BODY SYSTEM None ____________________________________________________________________________________________________________________________________ a Number of animals examined microscopically at site and number of animals with lesion Page 2 NTP Experiment-Test: 97013-90 INCIDENCE RATES OF NONNEOPLASTIC LESIONS BY ANATOMIC SITE (a) Report: PEIRPT03 Study Type: 26-39 WEEKS WATER DISINFECTION MODEL (DICHLOROACETIC ACID) Date: 12/05/03 Route: DOSED WATER Time: 09:33:35 ____________________________________________________________________________________________________________________________________ P53+/-(C57BL/6) FEMALE 0 MG/L 500 MG/L 1000MG/L 2000MG/L ____________________________________________________________________________________________________________________________________ GENITAL SYSTEM Ovary (10) (10) (10) (10) Cyst 1 (10%) 1 (10%) 7 (70%) Uterus (10) (10) (10) (10) Inflammation, Chronic Active 2 (20%) 1 (10%) 1 (10%) Endometrium, Hyperplasia, Cystic 7 (70%) 9 (90%) 9 (90%) 9 (90%) ____________________________________________________________________________________________________________________________________ HEMATOPOIETIC SYSTEM Lymph Node, Mandibular (10) (10) (10) (10) Hyperplasia, Lymphoid 2 (20%) Spleen (10) (10) (10) (10) Hematopoietic Cell Proliferation 1 (10%) 2 (20%) 2 (20%) Hyperplasia, Lymphoid 1 (10%) Thymus (10) (10) (10) (10) Atrophy 1 (10%) Cyst 9 (90%) 8 (80%) 7 (70%) 8 (80%) Ectopic Parathyroid Gland 1 (10%) ____________________________________________________________________________________________________________________________________ INTEGUMENTARY SYSTEM Skin (1) (1) Hyperkeratosis 1 (100%) Hyperplasia 1 (100%) Inflammation, Chronic Active 1 (100%) Ulcer 1 (100%) ____________________________________________________________________________________________________________________________________ MUSCULOSKELETAL SYSTEM None ____________________________________________________________________________________________________________________________________ NERVOUS SYSTEM None ____________________________________________________________________________________________________________________________________ RESPIRATORY SYSTEM None a Number of animals examined microscopically at site and number of animals with lesion Page 3 NTP Experiment-Test: 97013-90 INCIDENCE RATES OF NONNEOPLASTIC LESIONS BY ANATOMIC SITE (a) Report: PEIRPT03 Study Type: 26-39 WEEKS WATER DISINFECTION MODEL (DICHLOROACETIC ACID) Date: 12/05/03 Route: DOSED WATER Time: 09:33:35 ____________________________________________________________________________________________________________________________________ P53+/-(C57BL/6) FEMALE 0 MG/L 500 MG/L 1000MG/L 2000MG/L ____________________________________________________________________________________________________________________________________ SPECIAL SENSES SYSTEM None ____________________________________________________________________________________________________________________________________ URINARY SYSTEM Kidney (10) (10) (10) (10) Atrophy 1 (10%) Metaplasia, Osseous 1 (10%) Mineralization 2 (20%) 3 (30%) Nephropathy 4 (40%) 4 (40%) 7 (70%) 5 (50%) Renal Tubule, Dilatation 1 (10%) 1 (10%) a Number of animals examined microscopically at site and number of animals with lesion Page 4 NTP Experiment-Test: 97013-90 INCIDENCE RATES OF NONNEOPLASTIC LESIONS BY ANATOMIC SITE (a) Report: PEIRPT03 Study Type: 26-39 WEEKS WATER DISINFECTION MODEL (DICHLOROACETIC ACID) Date: 12/05/03 Route: DOSED WATER Time: 09:33:35 ____________________________________________________________________________________________________________________________________ P53+/-(C57BL/6) MALE 0 MG/L 500 MG/L 1000MG/L 2000MG/L ____________________________________________________________________________________________________________________________________ DISPOSITION SUMMARY Animals Initially In Study 10 10 10 10 Early Deaths Natural Death 1 1 Survivors Terminal Sacrifice 9 10 9 10 Animals Examined Microscopically 10 10 10 10 ____________________________________________________________________________________________________________________________________ ALIMENTARY SYSTEM Liver (10) (10) (10) (10) Hematopoietic Cell Proliferation 1 (10%) Inflammation, Chronic Active 9 (90%) 8 (80%) 7 (70%) 9 (90%) Hepatocyte, Fatty Change 6 (60%) 5 (50%) Hepatocyte, Necrosis 1 (10%) Hepatocyte, Vacuolization Cytoplasmic 9 (90%) 10 (100%) 10 (100%) 10 (100%) Stomach, Forestomach (10) (10) (10) (10) Inflammation, Chronic Active 1 (10%) 1 (10%) Ulcer 1 (10%) 1 (10%) Epithelium, Hyperkeratosis 1 (10%) 1 (10%) Epithelium, Hyperplasia 1 (10%) 1 (10%) ____________________________________________________________________________________________________________________________________ CARDIOVASCULAR SYSTEM None ____________________________________________________________________________________________________________________________________ ENDOCRINE SYSTEM Adrenal Cortex (10) (10) (10) (10) Hypertrophy 3 (30%) 3 (30%) 1 (10%) Subcapsular, Hyperplasia 3 (30%) 5 (50%) 3 (30%) 3 (30%) Pituitary Gland (10) (10) (10) (10) Pars Distalis, Cyst 4 (40%) 2 (20%) 2 (20%) Thyroid Gland (10) (10) (10) (10) Infiltration Cellular, Lymphocyte 1 (10%) 1 (10%) ____________________________________________________________________________________________________________________________________ GENERAL BODY SYSTEM a Number of animals examined microscopically at site and number of animals with lesion Page 5 NTP Experiment-Test: 97013-90 INCIDENCE RATES OF NONNEOPLASTIC LESIONS BY ANATOMIC SITE (a) Report: PEIRPT03 Study Type: 26-39 WEEKS WATER DISINFECTION MODEL (DICHLOROACETIC ACID) Date: 12/05/03 Route: DOSED WATER Time: 09:33:35 ____________________________________________________________________________________________________________________________________ P53+/-(C57BL/6) MALE 0 MG/L 500 MG/L 1000MG/L 2000MG/L ____________________________________________________________________________________________________________________________________ None ____________________________________________________________________________________________________________________________________ GENITAL SYSTEM Epididymis (10) (10) (10) (10) Degeneration 1 (10%) Inflammation, Chronic Active 3 (30%) 2 (20%) 1 (10%) 3 (30%) Testes (10) (10) (10) (10) Mineralization 1 (10%) Germinal Epithelium, Degeneration 5 (50%) 4 (40%) 2 (20%) 4 (40%) ____________________________________________________________________________________________________________________________________ HEMATOPOIETIC SYSTEM Lymph Node, Mandibular (10) (10) (10) (10) Hyperplasia, Lymphoid 1 (10%) Spleen (10) (10) (10) (10) Hematopoietic Cell Proliferation 1 (10%) 1 (10%) Thymus (10) (10) (10) (10) Atrophy 1 (10%) Cyst 6 (60%) 3 (30%) 2 (20%) 2 (20%) Ectopic Parathyroid Gland 2 (20%) 3 (30%) Hyperplasia, Lymphoid 1 (10%) 1 (10%) ____________________________________________________________________________________________________________________________________ INTEGUMENTARY SYSTEM None ____________________________________________________________________________________________________________________________________ MUSCULOSKELETAL SYSTEM None ____________________________________________________________________________________________________________________________________ NERVOUS SYSTEM None ____________________________________________________________________________________________________________________________________ RESPIRATORY SYSTEM Lung (10) (10) (10) (10) a Number of animals examined microscopically at site and number of animals with lesion Page 6 NTP Experiment-Test: 97013-90 INCIDENCE RATES OF NONNEOPLASTIC LESIONS BY ANATOMIC SITE (a) Report: PEIRPT03 Study Type: 26-39 WEEKS WATER DISINFECTION MODEL (DICHLOROACETIC ACID) Date: 12/05/03 Route: DOSED WATER Time: 09:33:35 ____________________________________________________________________________________________________________________________________ P53+/-(C57BL/6) MALE 0 MG/L 500 MG/L 1000MG/L 2000MG/L ____________________________________________________________________________________________________________________________________ RESPIRATORY SYSTEM - CONT Thrombosis 1 (10%) ____________________________________________________________________________________________________________________________________ SPECIAL SENSES SYSTEM None ____________________________________________________________________________________________________________________________________ URINARY SYSTEM Kidney (10) (10) (10) (10) Hydronephrosis 1 (10%) Metaplasia, Osseous 1 (10%) Mineralization 1 (10%) Nephropathy 9 (90%) 6 (60%) 8 (80%) 8 (80%) Renal Tubule, Dilatation 1 (10%) 2 (20%) 1 (10%) a Number of animals examined microscopically at site and number of animals with lesion Page 7 ------------------------------------------------------------ ---------- END OF REPORT ---------- ------------------------------------------------------------