TDMS Study 97013-90 Pathology Tables
NTP Experiment-Test: 97013-90 INCIDENCE RATES OF NEOPLASMS BY ANATOMIC SITE (SYSTEMIC LESIONS ABRIDGED) (a) Report: PEIRPT05
Study Type: 26-39 WEEKS WATER DISINFECTION MODEL (DICHLOROACETIC ACID) Date: 12/05/03
Route: DOSED WATER Time: 09:34:47
FINAL #1 MICE
Facility: Battelle Columbus Laboratory
Chemical CAS #: 79-43-6
Lock Date: 07/31/01
Cage Range: All
Reasons For Removal: All
Removal Date Range: All
Treatment Groups: Include All
a Number of animals examined microscopically at site and number of animals with lesion
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NTP Experiment-Test: 97013-90 INCIDENCE RATES OF NEOPLASMS BY ANATOMIC SITE (SYSTEMIC LESIONS ABRIDGED) (a) Report: PEIRPT05
Study Type: 26-39 WEEKS WATER DISINFECTION MODEL (DICHLOROACETIC ACID) Date: 12/05/03
Route: DOSED WATER Time: 09:34:47
____________________________________________________________________________________________________________________________________
P53+/-(C57BL/6) FEMALE 0 MG/L 500 MG/L 1000MG/L 2000MG/L
____________________________________________________________________________________________________________________________________
DISPOSITION SUMMARY
Animals Initially in Study 10 10 10 10
Early Deaths
Moribund Sacrifice 1
Natural Death 1
Survivors
Terminal Sacrifice 10 9 10 9
Animals Examined Microscopically 10 10 10 10
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ALIMENTARY SYSTEM
None
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CARDIOVASCULAR SYSTEM
None
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ENDOCRINE SYSTEM
None
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GENERAL BODY SYSTEM
None
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GENITAL SYSTEM
Uterus (10) (10) (10) (10)
Polyp Stromal 1 (10%)
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HEMATOPOIETIC SYSTEM
None
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NTP Experiment-Test: 97013-90 INCIDENCE RATES OF NEOPLASMS BY ANATOMIC SITE (SYSTEMIC LESIONS ABRIDGED) (a) Report: PEIRPT05
Study Type: 26-39 WEEKS WATER DISINFECTION MODEL (DICHLOROACETIC ACID) Date: 12/05/03
Route: DOSED WATER Time: 09:34:47
____________________________________________________________________________________________________________________________________
P53+/-(C57BL/6) FEMALE 0 MG/L 500 MG/L 1000MG/L 2000MG/L
____________________________________________________________________________________________________________________________________
INTEGUMENTARY SYSTEM
Skin (1) (1)
Subcutaneous Tissue, Rhabdomyosarcoma 1 (100%)
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MUSCULOSKELETAL SYSTEM
Bone (1) (1)
Osteosarcoma 1 (100%) 1 (100%)
Skeletal Muscle (1) (1)
Osteosarcoma, Metastatic, Bone 1 (100%) 1 (100%)
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NERVOUS SYSTEM
Spinal Cord (1)
Osteosarcoma, Metastatic, Bone 1 (100%)
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RESPIRATORY SYSTEM
None
____________________________________________________________________________________________________________________________________
SPECIAL SENSES SYSTEM
None
____________________________________________________________________________________________________________________________________
URINARY SYSTEM
None
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NTP Experiment-Test: 97013-90 INCIDENCE RATES OF NEOPLASMS BY ANATOMIC SITE (SYSTEMIC LESIONS ABRIDGED) (a) Report: PEIRPT05
Study Type: 26-39 WEEKS WATER DISINFECTION MODEL (DICHLOROACETIC ACID) Date: 12/05/03
Route: DOSED WATER Time: 09:34:47
____________________________________________________________________________________________________________________________________
P53+/-(C57BL/6) FEMALE 0 MG/L 500 MG/L 1000MG/L 2000MG/L
____________________________________________________________________________________________________________________________________
TUMOR SUMMARY
Total Animals with Primary Neoplasms (b) 2 2
Total Primary Neoplasms 2 2
Total Animals with Benign Neoplasms 1
Total Benign Neoplasms 1
Total Animals with Malignant Neoplasms 1 2
Total Malignant Neoplasms 1 2
Total Animals with Metastatic Neoplasms 1 1
Total Metastatic Neoplasm 2 1
Total Animals with Malignant Neoplasms
Uncertain Primary Site
Total Animals with Neoplasms Uncertain-
Benign or Malignant
Total Uncertain Neoplasms
____________________________________________________________________________________________________________________________________
a Number of animals examined microscopically at site and number of animals with lesion
b Primary tumors: all tumors except metastatic tumors
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NTP Experiment-Test: 97013-90 INCIDENCE RATES OF NEOPLASMS BY ANATOMIC SITE (SYSTEMIC LESIONS ABRIDGED) (a) Report: PEIRPT05
Study Type: 26-39 WEEKS WATER DISINFECTION MODEL (DICHLOROACETIC ACID) Date: 12/05/03
Route: DOSED WATER Time: 09:34:47
____________________________________________________________________________________________________________________________________
P53+/-(C57BL/6) MALE 0 MG/L 500 MG/L 1000MG/L 2000MG/L
____________________________________________________________________________________________________________________________________
DISPOSITION SUMMARY
Animals Initially in Study 10 10 10 10
Early Deaths
Natural Death 1 1
Survivors
Terminal Sacrifice 9 10 9 10
Animals Examined Microscopically 10 10 10 10
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ALIMENTARY SYSTEM
Liver (10) (10) (10) (10)
Hepatocellular Adenoma 2 (20%)
Osteosarcoma, Metastatic, Bone 1 (10%)
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CARDIOVASCULAR SYSTEM
None
____________________________________________________________________________________________________________________________________
ENDOCRINE SYSTEM
Adrenal Cortex (10) (10) (10) (10)
Thymoma Malignant, Metastatic, Thymus 1 (10%)
____________________________________________________________________________________________________________________________________
GENERAL BODY SYSTEM
None
____________________________________________________________________________________________________________________________________
GENITAL SYSTEM
None
____________________________________________________________________________________________________________________________________
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NTP Experiment-Test: 97013-90 INCIDENCE RATES OF NEOPLASMS BY ANATOMIC SITE (SYSTEMIC LESIONS ABRIDGED) (a) Report: PEIRPT05
Study Type: 26-39 WEEKS WATER DISINFECTION MODEL (DICHLOROACETIC ACID) Date: 12/05/03
Route: DOSED WATER Time: 09:34:47
____________________________________________________________________________________________________________________________________
P53+/-(C57BL/6) MALE 0 MG/L 500 MG/L 1000MG/L 2000MG/L
____________________________________________________________________________________________________________________________________
HEMATOPOIETIC SYSTEM
Spleen (10) (10) (10) (10)
Thymus (10) (10) (10) (10)
Thymoma Malignant 1 (10%)
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INTEGUMENTARY SYSTEM
None
____________________________________________________________________________________________________________________________________
MUSCULOSKELETAL SYSTEM
Bone (1) (1)
Osteosarcoma 1 (100%) 1 (100%)
____________________________________________________________________________________________________________________________________
NERVOUS SYSTEM
None
____________________________________________________________________________________________________________________________________
RESPIRATORY SYSTEM
Lung (10) (10) (10) (10)
Thymoma Malignant, Metastatic, Thymus 1 (10%)
____________________________________________________________________________________________________________________________________
SPECIAL SENSES SYSTEM
None
____________________________________________________________________________________________________________________________________
URINARY SYSTEM
Kidney (10) (10) (10) (10)
Thymoma Malignant, Metastatic, Thymus 1 (10%)
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NTP Experiment-Test: 97013-90 INCIDENCE RATES OF NEOPLASMS BY ANATOMIC SITE (SYSTEMIC LESIONS ABRIDGED) (a) Report: PEIRPT05
Study Type: 26-39 WEEKS WATER DISINFECTION MODEL (DICHLOROACETIC ACID) Date: 12/05/03
Route: DOSED WATER Time: 09:34:47
____________________________________________________________________________________________________________________________________
P53+/-(C57BL/6) MALE 0 MG/L 500 MG/L 1000MG/L 2000MG/L
____________________________________________________________________________________________________________________________________
SYSTEMIC LESIONS
Multiple Organs *(10) *(10) *(10) *(10)
Lymphoma Malignant 1 (10%)
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* Number of animals with any tissue examined microscopically
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NTP Experiment-Test: 97013-90 INCIDENCE RATES OF NEOPLASMS BY ANATOMIC SITE (SYSTEMIC LESIONS ABRIDGED) (a) Report: PEIRPT05
Study Type: 26-39 WEEKS WATER DISINFECTION MODEL (DICHLOROACETIC ACID) Date: 12/05/03
Route: DOSED WATER Time: 09:34:47
____________________________________________________________________________________________________________________________________
P53+/-(C57BL/6) MALE 0 MG/L 500 MG/L 1000MG/L 2000MG/L
____________________________________________________________________________________________________________________________________
TUMOR SUMMARY
Total Animals with Primary Neoplasms (b) 1 3 1
Total Primary Neoplasms 1 4 1
Total Animals with Benign Neoplasms 2
Total Benign Neoplasms 2
Total Animals with Malignant Neoplasms 1 2 1
Total Malignant Neoplasms 1 2 1
Total Animals with Metastatic Neoplasms 1 1
Total Metastatic Neoplasm 1 3
Total Animals with Malignant Neoplasms
Uncertain Primary Site
Total Animals with Neoplasms Uncertain-
Benign or Malignant
Total Uncertain Neoplasms
____________________________________________________________________________________________________________________________________
a Number of animals examined microscopically at site and number of animals with lesion
b Primary tumors: all tumors except metastatic tumors
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