TDMS Study 97013-91 Pathology Tables
NTP Experiment-Test: 97013-91 INCIDENCE RATES OF NONNEOPLASTIC LESIONS BY ANATOMIC SITE (a) Report: PEIRPT03 Study Type: 26-39 WEEKS WATER DISINFECTION MODEL (DICHLOROACETIC ACID) Date: 12/05/03 Route: DOSED WATER Time: 09:37:52 FINAL#1 MICE Facility: Battelle Columbus Laboratory Chemical CAS #: 79-43-6 Lock Date: 07/31/01 Cage Range: All Reasons For Removal: All Removal Date Range: All Treatment Groups: Include All a Number of animals examined microscopically at site and number of animals with lesion Page 1 NTP Experiment-Test: 97013-91 INCIDENCE RATES OF NONNEOPLASTIC LESIONS BY ANATOMIC SITE (a) Report: PEIRPT03 Study Type: 26-39 WEEKS WATER DISINFECTION MODEL (DICHLOROACETIC ACID) Date: 12/05/03 Route: DOSED WATER Time: 09:37:52 ____________________________________________________________________________________________________________________________________ TGAC (FVB/N) HEMIZYGOUS FEMALE 0 MG/L 500 MG/L 1000MG/L 2000MG/L ____________________________________________________________________________________________________________________________________ DISPOSITION SUMMARY Animals Initially In Study 10 10 10 10 Early Deaths Moribund Sacrifice 1 1 2 Natural Death 2 1 2 Survivors Terminal Sacrifice 7 9 7 8 Animals Examined Microscopically 10 10 10 10 ____________________________________________________________________________________________________________________________________ ALIMENTARY SYSTEM Liver (10) (10) (10) (10) Inflammation, Chronic Active 7 (70%) 10 (100%) 9 (90%) 8 (80%) Hepatocyte, Fatty Change 1 (10%) Hepatocyte, Necrosis 1 (10%) 1 (10%) 1 (10%) 4 (40%) Hepatocyte, Vacuolization Cytoplasmic 7 (70%) 9 (90%) 9 (90%) 10 (100%) Stomach, Forestomach (10) (10) (10) (10) Epithelium, Hyperkeratosis 1 (10%) Epithelium, Hyperplasia 1 (10%) ____________________________________________________________________________________________________________________________________ CARDIOVASCULAR SYSTEM None ____________________________________________________________________________________________________________________________________ ENDOCRINE SYSTEM Adrenal Cortex (10) (10) (10) (10) Accessory Adrenal Cortical Nodule 2 (20%) 2 (20%) 2 (20%) 3 (30%) Subcapsular, Hyperplasia 3 (30%) 5 (50%) 4 (40%) 8 (80%) Adrenal Medulla (10) (10) (10) (10) Mineralization 1 (10%) Pituitary Gland (10) (10) (10) (10) Pars Distalis, Cyst 2 (20%) 2 (20%) 2 (20%) 2 (20%) Thyroid Gland (10) (10) (10) (10) Ectopic Thymus 1 (10%) Follicle, Degeneration 3 (30%) 6 (60%) 5 (50%) 5 (50%) ____________________________________________________________________________________________________________________________________ GENERAL BODY SYSTEM a Number of animals examined microscopically at site and number of animals with lesion Page 2 NTP Experiment-Test: 97013-91 INCIDENCE RATES OF NONNEOPLASTIC LESIONS BY ANATOMIC SITE (a) Report: PEIRPT03 Study Type: 26-39 WEEKS WATER DISINFECTION MODEL (DICHLOROACETIC ACID) Date: 12/05/03 Route: DOSED WATER Time: 09:37:52 ____________________________________________________________________________________________________________________________________ TGAC (FVB/N) HEMIZYGOUS FEMALE 0 MG/L 500 MG/L 1000MG/L 2000MG/L ____________________________________________________________________________________________________________________________________ None ____________________________________________________________________________________________________________________________________ GENITAL SYSTEM Ovary (10) (10) (10) (10) Cyst 7 (70%) 4 (40%) 1 (10%) Inflammation, Chronic Active 1 (10%) Uterus (10) (10) (10) (10) Endometrium, Hyperplasia, Cystic 7 (70%) 9 (90%) 7 (70%) 7 (70%) ____________________________________________________________________________________________________________________________________ HEMATOPOIETIC SYSTEM Lymph Node, Mandibular (10) (10) (10) (10) Hyperplasia, Lymphoid 1 (10%) 1 (10%) 1 (10%) Spleen (10) (10) (10) (10) Atrophy 1 (10%) Hematopoietic Cell Proliferation 1 (10%) 1 (10%) Thymus (10) (10) (9) (10) Atrophy 3 (30%) 1 (10%) 1 (11%) 1 (10%) Cyst 3 (30%) 4 (40%) 2 (22%) 5 (50%) Ectopic Parathyroid Gland 1 (10%) Thrombosis 1 (10%) Thymocyte, Necrosis 1 (10%) ____________________________________________________________________________________________________________________________________ INTEGUMENTARY SYSTEM Skin (6) (7) (7) (7) Hyperkeratosis 1 (14%) Inflammation, Chronic Active 1 (14%) Epidermis, Hyperplasia 1 (17%) 2 (29%) ____________________________________________________________________________________________________________________________________ MUSCULOSKELETAL SYSTEM None ____________________________________________________________________________________________________________________________________ NERVOUS SYSTEM None a Number of animals examined microscopically at site and number of animals with lesion Page 3 NTP Experiment-Test: 97013-91 INCIDENCE RATES OF NONNEOPLASTIC LESIONS BY ANATOMIC SITE (a) Report: PEIRPT03 Study Type: 26-39 WEEKS WATER DISINFECTION MODEL (DICHLOROACETIC ACID) Date: 12/05/03 Route: DOSED WATER Time: 09:37:52 ____________________________________________________________________________________________________________________________________ TGAC (FVB/N) HEMIZYGOUS FEMALE 0 MG/L 500 MG/L 1000MG/L 2000MG/L ____________________________________________________________________________________________________________________________________ RESPIRATORY SYSTEM None ____________________________________________________________________________________________________________________________________ SPECIAL SENSES SYSTEM None ____________________________________________________________________________________________________________________________________ URINARY SYSTEM Kidney (10) (10) (10) (10) Infarct 1 (10%) Mineralization 1 (10%) Nephropathy 3 (30%) 5 (50%) 2 (20%) 7 (70%) Glomerulus, Inflammation, Membranoproliferative 3 (30%) 1 (10%) 1 (10%) Renal Tubule, Dilatation 3 (30%) 1 (10%) 2 (20%) a Number of animals examined microscopically at site and number of animals with lesion Page 4 NTP Experiment-Test: 97013-91 INCIDENCE RATES OF NONNEOPLASTIC LESIONS BY ANATOMIC SITE (a) Report: PEIRPT03 Study Type: 26-39 WEEKS WATER DISINFECTION MODEL (DICHLOROACETIC ACID) Date: 12/05/03 Route: DOSED WATER Time: 09:37:52 ____________________________________________________________________________________________________________________________________ TGAC (FVB/N) HEMIZYGOUS MALE 0 MG/L 500 MG/L 1000MG/L 2000MG/L ____________________________________________________________________________________________________________________________________ DISPOSITION SUMMARY Animals Initially In Study 10 10 10 10 Early Deaths Natural Death 1 Moribund Sacrifice 1 Survivors Terminal Sacrifice 9 9 10 10 Animals Examined Microscopically 10 10 10 10 ____________________________________________________________________________________________________________________________________ ALIMENTARY SYSTEM Liver (10) (10) (10) (10) Hematopoietic Cell Proliferation 1 (10%) Inflammation, Acute 1 (10%) 1 (10%) 1 (10%) Inflammation, Chronic Active 9 (90%) 7 (70%) 5 (50%) 7 (70%) Hepatocyte, Necrosis 1 (10%) 1 (10%) 1 (10%) 3 (30%) Hepatocyte, Vacuolization Cytoplasmic 9 (90%) 10 (100%) 9 (90%) 10 (100%) Mesentery (1) (3) (1) Fat, Fibrosis 2 (67%) 1 (100%) Fat, Inflammation, Chronic Active 1 (33%) 1 (100%) Fat, Necrosis 1 (100%) 3 (100%) 1 (100%) Fat, Pigmentation 1 (100%) Stomach, Forestomach (10) (10) (10) (10) Epithelium, Hyperplasia 3 (30%) 1 (10%) ____________________________________________________________________________________________________________________________________ CARDIOVASCULAR SYSTEM None ____________________________________________________________________________________________________________________________________ ENDOCRINE SYSTEM Adrenal Cortex (10) (10) (10) (10) Accessory Adrenal Cortical Nodule 1 (10%) 1 (10%) 1 (10%) Atypia Cellular 1 (10%) Hematopoietic Cell Proliferation 1 (10%) 1 (10%) Hypertrophy 8 (80%) 6 (60%) 9 (90%) 7 (70%) Subcapsular, Hyperplasia 2 (20%) 1 (10%) 1 (10%) Pituitary Gland (10) (10) (10) (10) Pars Distalis, Cyst 2 (20%) 1 (10%) 1 (10%) a Number of animals examined microscopically at site and number of animals with lesion Page 5 NTP Experiment-Test: 97013-91 INCIDENCE RATES OF NONNEOPLASTIC LESIONS BY ANATOMIC SITE (a) Report: PEIRPT03 Study Type: 26-39 WEEKS WATER DISINFECTION MODEL (DICHLOROACETIC ACID) Date: 12/05/03 Route: DOSED WATER Time: 09:37:52 ____________________________________________________________________________________________________________________________________ TGAC (FVB/N) HEMIZYGOUS MALE 0 MG/L 500 MG/L 1000MG/L 2000MG/L ____________________________________________________________________________________________________________________________________ ENDOCRINE SYSTEM - CONT Thyroid Gland (10) (10) (10) (10) Ectopic Thymus 1 (10%) Infiltration Cellular, Lymphocyte 1 (10%) 1 (10%) Follicle, Degeneration 3 (30%) 9 (90%) 5 (50%) 4 (40%) ____________________________________________________________________________________________________________________________________ GENERAL BODY SYSTEM None ____________________________________________________________________________________________________________________________________ GENITAL SYSTEM Epididymis (10) (10) (10) (10) Cyst 1 (10%) Degeneration 1 (10%) 1 (10%) 3 (30%) Inflammation, Chronic Active 1 (10%) Preputial Gland (2) (4) (2) Inflammation, Chronic Active 1 (50%) Duct, Ectasia 2 (100%) 4 (100%) 2 (100%) Seminal Vesicle (1) (1) Inflammation, Chronic Active 1 (100%) Inflammation, Suppurative 1 (100%) Testes (10) (10) (10) (10) Cyst 1 (10%) Mineralization 1 (10%) Germinal Epithelium, Degeneration 1 (10%) 1 (10%) 3 (30%) Interstitial Cell, Hyperplasia 1 (10%) 1 (10%) ____________________________________________________________________________________________________________________________________ HEMATOPOIETIC SYSTEM Lymph Node (1) (2) Lumbar, Hematopoietic Cell Proliferation 1 (100%) Lumbar, Hyperplasia, Lymphoid 1 (100%) Mediastinal, Hematopoietic Cell Proliferation 1 (100%) Mediastinal, Hyperplasia, Lymphoid 1 (100%) Mediastinal, Infiltration Cellular, Mast Cell 1 (50%) Mediastinal, Infiltration Cellular, Histiocyte 1 (50%) Renal, Hematopoietic Cell Proliferation 1 (100%) Renal, Hyperplasia, Lymphoid 1 (100%) Lymph Node, Mandibular (10) (10) (10) (10) a Number of animals examined microscopically at site and number of animals with lesion Page 6 NTP Experiment-Test: 97013-91 INCIDENCE RATES OF NONNEOPLASTIC LESIONS BY ANATOMIC SITE (a) Report: PEIRPT03 Study Type: 26-39 WEEKS WATER DISINFECTION MODEL (DICHLOROACETIC ACID) Date: 12/05/03 Route: DOSED WATER Time: 09:37:52 ____________________________________________________________________________________________________________________________________ TGAC (FVB/N) HEMIZYGOUS MALE 0 MG/L 500 MG/L 1000MG/L 2000MG/L ____________________________________________________________________________________________________________________________________ HEMATOPOIETIC SYSTEM - CONT Hyperplasia, Lymphoid 1 (10%) 1 (10%) Spleen (10) (10) (10) (10) Hematopoietic Cell Proliferation 1 (10%) 1 (10%) Necrosis 1 (10%) Thymus (10) (10) (9) (10) Atrophy 2 (20%) 1 (10%) 1 (11%) Cyst 2 (20%) 3 (30%) 4 (44%) 3 (30%) Ectopic Parathyroid Gland 2 (22%) ____________________________________________________________________________________________________________________________________ INTEGUMENTARY SYSTEM Skin (9) (9) (9) (8) Inflammation, Chronic Active 1 (11%) 1 (13%) Epidermis, Hyperplasia 5 (56%) 4 (44%) 1 (13%) ____________________________________________________________________________________________________________________________________ MUSCULOSKELETAL SYSTEM None ____________________________________________________________________________________________________________________________________ NERVOUS SYSTEM None ____________________________________________________________________________________________________________________________________ RESPIRATORY SYSTEM Lung (10) (10) (10) (10) Hemorrhage 1 (10%) Infiltration Cellular, Polymorphonuclear 1 (10%) Inflammation, Chronic Active 2 (20%) 1 (10%) Alveolar Epithelium, Hyperplasia 1 (10%) ____________________________________________________________________________________________________________________________________ SPECIAL SENSES SYSTEM None ____________________________________________________________________________________________________________________________________ URINARY SYSTEM a Number of animals examined microscopically at site and number of animals with lesion Page 7 NTP Experiment-Test: 97013-91 INCIDENCE RATES OF NONNEOPLASTIC LESIONS BY ANATOMIC SITE (a) Report: PEIRPT03 Study Type: 26-39 WEEKS WATER DISINFECTION MODEL (DICHLOROACETIC ACID) Date: 12/05/03 Route: DOSED WATER Time: 09:37:52 ____________________________________________________________________________________________________________________________________ TGAC (FVB/N) HEMIZYGOUS MALE 0 MG/L 500 MG/L 1000MG/L 2000MG/L ____________________________________________________________________________________________________________________________________ URINARY SYSTEM - CONT Kidney (10) (10) (10) (10) Infarct 1 (10%) Inflammation, Chronic Active 1 (10%) Mineralization 1 (10%) Necrosis 1 (10%) Nephropathy 9 (90%) 8 (80%) 7 (70%) 10 (100%) Pelvis, Inflammation, Chronic 1 (10%) Renal Tubule, Cyst 1 (10%) Renal Tubule, Dilatation 4 (40%) 6 (60%) 6 (60%) 5 (50%) Renal Tubule, Nephropathy 1 (10%) a Number of animals examined microscopically at site and number of animals with lesion Page 8 ------------------------------------------------------------ ---------- END OF REPORT ---------- ------------------------------------------------------------