TDMS Study 97013-91 Pathology Tables
NTP Experiment-Test: 97013-91 INCIDENCE RATES OF NEOPLASMS BY ANATOMIC SITE (SYSTEMIC LESIONS ABRIDGED) (a) Report: PEIRPT05
Study Type: 26-39 WEEKS WATER DISINFECTION MODEL (DICHLOROACETIC ACID) Date: 12/05/03
Route: DOSED WATER Time: 09:39:19
FINAL#1 MICE
Facility: Battelle Columbus Laboratory
Chemical CAS #: 79-43-6
Lock Date: 07/31/01
Cage Range: All
Reasons For Removal: All
Removal Date Range: All
Treatment Groups: Include All
a Number of animals examined microscopically at site and number of animals with lesion
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NTP Experiment-Test: 97013-91 INCIDENCE RATES OF NEOPLASMS BY ANATOMIC SITE (SYSTEMIC LESIONS ABRIDGED) (a) Report: PEIRPT05
Study Type: 26-39 WEEKS WATER DISINFECTION MODEL (DICHLOROACETIC ACID) Date: 12/05/03
Route: DOSED WATER Time: 09:39:19
____________________________________________________________________________________________________________________________________
TGAC (FVB/N) HEMIZYGOUS FEMALE 0 MG/L 500 MG/L 1000MG/L 2000MG/L
____________________________________________________________________________________________________________________________________
DISPOSITION SUMMARY
Animals Initially in Study 10 10 10 10
Early Deaths
Moribund Sacrifice 1 1 2
Natural Death 2 1 2
Survivors
Terminal Sacrifice 7 9 7 8
Animals Examined Microscopically 10 10 10 10
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ALIMENTARY SYSTEM
Intestine Large, Rectum (1)
Anus, Squamous Cell Papilloma 1 (100%)
Liver (10) (10) (10) (10)
Stomach, Forestomach (10) (10) (10) (10)
Squamous Cell Papilloma 5 (50%) 1 (10%) 3 (30%) 2 (20%)
Squamous Cell Papilloma, Multiple 1 (10%) 6 (60%) 4 (40%) 4 (40%)
Tooth (1) (2) (3) (3)
Odontogenic Tumor 1 (100%) 2 (100%) 3 (100%) 3 (100%)
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CARDIOVASCULAR SYSTEM
None
____________________________________________________________________________________________________________________________________
ENDOCRINE SYSTEM
Adrenal Cortex (10) (10) (10) (10)
Adrenal Medulla (10) (10) (10) (10)
Pituitary Gland (10) (10) (10) (10)
____________________________________________________________________________________________________________________________________
GENERAL BODY SYSTEM
None
____________________________________________________________________________________________________________________________________
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NTP Experiment-Test: 97013-91 INCIDENCE RATES OF NEOPLASMS BY ANATOMIC SITE (SYSTEMIC LESIONS ABRIDGED) (a) Report: PEIRPT05
Study Type: 26-39 WEEKS WATER DISINFECTION MODEL (DICHLOROACETIC ACID) Date: 12/05/03
Route: DOSED WATER Time: 09:39:19
____________________________________________________________________________________________________________________________________
TGAC (FVB/N) HEMIZYGOUS FEMALE 0 MG/L 500 MG/L 1000MG/L 2000MG/L
____________________________________________________________________________________________________________________________________
GENITAL SYSTEM
Ovary (10) (10) (10) (10)
Oviduct (1)
Adenoma 1 (100%)
____________________________________________________________________________________________________________________________________
HEMATOPOIETIC SYSTEM
Lymph Node (1) (1)
Spleen (10) (10) (10) (10)
Thymus (10) (10) (9) (10)
____________________________________________________________________________________________________________________________________
INTEGUMENTARY SYSTEM
Skin (6) (7) (7) (7)
Squamous Cell Papilloma 1 (17%) 2 (29%) 4 (57%) 4 (57%)
Squamous Cell Papilloma, Multiple 5 (83%) 5 (71%) 2 (29%) 3 (43%)
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MUSCULOSKELETAL SYSTEM
None
____________________________________________________________________________________________________________________________________
NERVOUS SYSTEM
None
____________________________________________________________________________________________________________________________________
RESPIRATORY SYSTEM
Lung (10) (10) (10) (10)
Alveolar/Bronchiolar Adenoma 2 (20%)
____________________________________________________________________________________________________________________________________
SPECIAL SENSES SYSTEM
None
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NTP Experiment-Test: 97013-91 INCIDENCE RATES OF NEOPLASMS BY ANATOMIC SITE (SYSTEMIC LESIONS ABRIDGED) (a) Report: PEIRPT05
Study Type: 26-39 WEEKS WATER DISINFECTION MODEL (DICHLOROACETIC ACID) Date: 12/05/03
Route: DOSED WATER Time: 09:39:19
____________________________________________________________________________________________________________________________________
TGAC (FVB/N) HEMIZYGOUS FEMALE 0 MG/L 500 MG/L 1000MG/L 2000MG/L
____________________________________________________________________________________________________________________________________
URINARY SYSTEM
Kidney (10) (10) (10) (10)
____________________________________________________________________________________________________________________________________
SYSTEMIC LESIONS
Multiple Organs *(10) *(10) *(10) *(10)
Leukemia Erythrocytic 3 (30%) 1 (10%) 1 (10%)
Lymphoma Malignant 1 (10%)
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* Number of animals with any tissue examined microscopically
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NTP Experiment-Test: 97013-91 INCIDENCE RATES OF NEOPLASMS BY ANATOMIC SITE (SYSTEMIC LESIONS ABRIDGED) (a) Report: PEIRPT05
Study Type: 26-39 WEEKS WATER DISINFECTION MODEL (DICHLOROACETIC ACID) Date: 12/05/03
Route: DOSED WATER Time: 09:39:19
____________________________________________________________________________________________________________________________________
TGAC (FVB/N) HEMIZYGOUS FEMALE 0 MG/L 500 MG/L 1000MG/L 2000MG/L
____________________________________________________________________________________________________________________________________
TUMOR SUMMARY
Total Animals with Primary Neoplasms (b) 9 9 8 9
Total Primary Neoplasms 17 18 17 19
Total Animals with Benign Neoplasms 7 8 7 8
Total Benign Neoplasms 13 15 13 15
Total Animals with Malignant Neoplasms 3 1 1 1
Total Malignant Neoplasms 3 1 1 1
Total Animals with Metastatic Neoplasms
Total Metastatic Neoplasm
Total Animals with Malignant Neoplasms
Uncertain Primary Site
Total Animals with Neoplasms Uncertain-
Benign or Malignant 1 2 3 3
Total Uncertain Neoplasms 1 2 3 3
____________________________________________________________________________________________________________________________________
a Number of animals examined microscopically at site and number of animals with lesion
b Primary tumors: all tumors except metastatic tumors
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NTP Experiment-Test: 97013-91 INCIDENCE RATES OF NEOPLASMS BY ANATOMIC SITE (SYSTEMIC LESIONS ABRIDGED) (a) Report: PEIRPT05
Study Type: 26-39 WEEKS WATER DISINFECTION MODEL (DICHLOROACETIC ACID) Date: 12/05/03
Route: DOSED WATER Time: 09:39:19
____________________________________________________________________________________________________________________________________
TGAC (FVB/N) HEMIZYGOUS MALE 0 MG/L 500 MG/L 1000MG/L 2000MG/L
____________________________________________________________________________________________________________________________________
DISPOSITION SUMMARY
Animals Initially in Study 10 10 10 10
Early Deaths
Natural Death 1
Moribund Sacrifice 1
Survivors
Terminal Sacrifice 9 9 10 10
Animals Examined Microscopically 10 10 10 10
____________________________________________________________________________________________________________________________________
ALIMENTARY SYSTEM
Liver (10) (10) (10) (10)
Hepatocellular Adenoma 1 (10%)
Stomach, Forestomach (10) (10) (10) (10)
Squamous Cell Papilloma 2 (20%) 3 (30%) 1 (10%) 2 (20%)
Squamous Cell Papilloma, Multiple 3 (30%) 6 (60%) 5 (50%) 5 (50%)
Tooth (2) (1) (1) (2)
Odontogenic Tumor 1 (100%) 1 (100%) 1 (50%)
Odontogenic Tumor, Multiple 2 (100%) 1 (50%)
____________________________________________________________________________________________________________________________________
CARDIOVASCULAR SYSTEM
None
____________________________________________________________________________________________________________________________________
ENDOCRINE SYSTEM
Adrenal Cortex (10) (10) (10) (10)
Adrenal Medulla (10) (10) (10) (10)
Pituitary Gland (10) (10) (10) (10)
____________________________________________________________________________________________________________________________________
GENERAL BODY SYSTEM
None
____________________________________________________________________________________________________________________________________
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NTP Experiment-Test: 97013-91 INCIDENCE RATES OF NEOPLASMS BY ANATOMIC SITE (SYSTEMIC LESIONS ABRIDGED) (a) Report: PEIRPT05
Study Type: 26-39 WEEKS WATER DISINFECTION MODEL (DICHLOROACETIC ACID) Date: 12/05/03
Route: DOSED WATER Time: 09:39:19
____________________________________________________________________________________________________________________________________
TGAC (FVB/N) HEMIZYGOUS MALE 0 MG/L 500 MG/L 1000MG/L 2000MG/L
____________________________________________________________________________________________________________________________________
GENITAL SYSTEM
None
____________________________________________________________________________________________________________________________________
HEMATOPOIETIC SYSTEM
Lymph Node, Mandibular (10) (10) (10) (10)
Spleen (10) (10) (10) (10)
____________________________________________________________________________________________________________________________________
INTEGUMENTARY SYSTEM
Skin (9) (9) (9) (8)
Squamous Cell Papilloma 1 (11%)
Squamous Cell Papilloma, Multiple 9 (100%) 8 (89%) 9 (100%) 8 (100%)
____________________________________________________________________________________________________________________________________
MUSCULOSKELETAL SYSTEM
None
____________________________________________________________________________________________________________________________________
NERVOUS SYSTEM
None
____________________________________________________________________________________________________________________________________
RESPIRATORY SYSTEM
Lung (10) (10) (10) (10)
Alveolar/Bronchiolar Adenoma 1 (10%) 7 (70%) 3 (30%)
Alveolar/Bronchiolar Adenoma, Multiple 2 (20%)
____________________________________________________________________________________________________________________________________
SPECIAL SENSES SYSTEM
None
____________________________________________________________________________________________________________________________________
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NTP Experiment-Test: 97013-91 INCIDENCE RATES OF NEOPLASMS BY ANATOMIC SITE (SYSTEMIC LESIONS ABRIDGED) (a) Report: PEIRPT05
Study Type: 26-39 WEEKS WATER DISINFECTION MODEL (DICHLOROACETIC ACID) Date: 12/05/03
Route: DOSED WATER Time: 09:39:19
____________________________________________________________________________________________________________________________________
TGAC (FVB/N) HEMIZYGOUS MALE 0 MG/L 500 MG/L 1000MG/L 2000MG/L
____________________________________________________________________________________________________________________________________
URINARY SYSTEM
Kidney (10) (10) (10) (10)
____________________________________________________________________________________________________________________________________
SYSTEMIC LESIONS
Multiple Organs *(10) *(10) *(10) *(10)
Leukemia Erythrocytic 1 (10%)
____________________________________________________________________________________________________________________________________
* Number of animals with any tissue examined microscopically
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NTP Experiment-Test: 97013-91 INCIDENCE RATES OF NEOPLASMS BY ANATOMIC SITE (SYSTEMIC LESIONS ABRIDGED) (a) Report: PEIRPT05
Study Type: 26-39 WEEKS WATER DISINFECTION MODEL (DICHLOROACETIC ACID) Date: 12/05/03
Route: DOSED WATER Time: 09:39:19
____________________________________________________________________________________________________________________________________
TGAC (FVB/N) HEMIZYGOUS MALE 0 MG/L 500 MG/L 1000MG/L 2000MG/L
____________________________________________________________________________________________________________________________________
TUMOR SUMMARY
Total Animals with Primary Neoplasms (b) 9 9 10 9
Total Primary Neoplasms 17 21 24 21
Total Animals with Benign Neoplasms 9 9 10 9
Total Benign Neoplasms 15 20 22 19
Total Animals with Malignant Neoplasms 1
Total Malignant Neoplasms 1
Total Animals with Metastatic Neoplasms
Total Metastatic Neoplasm
Total Animals with Malignant Neoplasms
Uncertain Primary Site
Total Animals with Neoplasms Uncertain-
Benign or Malignant 2 1 1 2
Total Uncertain Neoplasms 2 1 1 2
____________________________________________________________________________________________________________________________________
a Number of animals examined microscopically at site and number of animals with lesion
b Primary tumors: all tumors except metastatic tumors
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