TDMS Study 97013-91 Pathology Tables
NTP Experiment-Test: 97013-91 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09 Study Type: 26-39 WEEKS WATER DISINFECTION MODEL (DICHLOROACETIC ACID) Date: 12/05/03 Route: DOSED WATER Time: 09:40:06 FINAL#1 MICE Facility: Battelle Columbus Laboratory Chemical CAS #: 79-43-6 Lock Date: 07/31/01 Cage Range: All Reasons For Removal: All Removal Date Range: All Treatment Groups: Include All Page 1 NTP Experiment-Test: 97013-91 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09 Study Type: 26-39 WEEKS WATER DISINFECTION MODEL (DICHLOROACETIC ACID) Date: 12/05/03 Route: DOSED WATER Time: 09:40:06 __________________________________________________________________________________________________________________________________ | 1| 1| 2| 2| 2| 2| 2| 2| 0| 2| | | DAY ON TEST | 4| 2| 8| 8| 8| 8| 8| 8| 9| 8| | | | 1| 0| 2| 2| 2| 2| 2| 2| 4| 2| | | __________________________________________|__________________________________________________________________________| T (*) | | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | O | TGAC (FVB/N) HEMIZYGOUS FEMALE | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| | T | ANIMAL ID | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | A | 0 MG/L | 4| 4| 4| 4| 4| 4| 4| 4| 4| 5| | L | | 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| | | _____________________________________________________________________________________________________________________|____________| ALIMENTARY SYSTEM | | | |__________________________________________________________________________|____________| Intestine Large, Colon | + + + + + + + + + + | 10 | |__________________________________________________________________________|____________| Intestine Large, Rectum | + | 1 | |__________________________________________________________________________|____________| Intestine Large, Cecum | + + + + + + + + + + | 10 | |__________________________________________________________________________|____________| Intestine Small, Duodenum | + + + + + + + + + + | 10 | |__________________________________________________________________________|____________| Intestine Small, Jejunum | + + + + + + + + + + | 10 | |__________________________________________________________________________|____________| Intestine Small, Ileum | + + + + + + + + + + | 10 | |__________________________________________________________________________|____________| Liver | + + + + + + + + + + | 10 | Inflammation, Chronic Active | 2 1 1 1 1 1 1 | 7 1.1| Hepatocyte, Necrosis | 2 | 1 2.0| Hepatocyte, Vacuolization Cytoplasmic| 2 2 2 2 2 2 2 | 7 2.0| |__________________________________________________________________________|____________| Stomach, Forestomach | + + + + + + + + + + | 10 | |__________________________________________________________________________|____________| Tooth | + | 1 | _____________________________________________________________________________________________________________________| | CARDIOVASCULAR SYSTEM | | | None | | | _____________________________________________________________________________________________________________________| | ENDOCRINE SYSTEM | | | |__________________________________________________________________________|____________| Adrenal Cortex | + + + + + + + + + + | 10 | Accessory Adrenal Cortical Nodule | 1 1 | 2 1.0| Subcapsular, Hyperplasia | 1 1 1 | 3 1.0| |__________________________________________________________________________|____________| Adrenal Medulla | + + + + + + + + + + | 10 | |__________________________________________________________________________|____________| Pituitary Gland | + + + + + + + + + + | 10 | _____________________________________________________________________________________________________________________|____________| * : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade + : Tissue examined microscopically M : Missing tissue 1-4 : Lesion qualified as: X : Lesion present but not qualified A : Autolysis precludes examination 1) Minimal 3) Moderate I : Insufficient tissue BLANK : Not examined 2) Mild 4) Marked Page 2 NTP Experiment-Test: 97013-91 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09 Study Type: 26-39 WEEKS WATER DISINFECTION MODEL (DICHLOROACETIC ACID) Date: 12/05/03 Route: DOSED WATER Time: 09:40:06 __________________________________________________________________________________________________________________________________ | 1| 1| 2| 2| 2| 2| 2| 2| 0| 2| | | DAY ON TEST | 4| 2| 8| 8| 8| 8| 8| 8| 9| 8| | | | 1| 0| 2| 2| 2| 2| 2| 2| 4| 2| | | __________________________________________|__________________________________________________________________________| T (*) | | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | O | TGAC (FVB/N) HEMIZYGOUS FEMALE | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| | T | ANIMAL ID | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | A | 0 MG/L | 4| 4| 4| 4| 4| 4| 4| 4| 4| 5| | L | | 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| | | _____________________________________________________________________________________________________________________|____________| ENDOCRINE SYSTEM - cont | | | Pars Distalis, Cyst | 1 2 | 2 1.5| |__________________________________________________________________________|____________| Thyroid Gland | + + + + + + + + + + | 10 | Follicle, Degeneration | 1 1 1 | 3 1.0| _____________________________________________________________________________________________________________________| | GENERAL BODY SYSTEM | | | None | | | _____________________________________________________________________________________________________________________| | GENITAL SYSTEM | | | |__________________________________________________________________________|____________| Ovary | + + + + + + + + + + | 10 | |__________________________________________________________________________|____________| Uterus | + + + + + + + + + + | 10 | Endometrium, Hyperplasia, Cystic | 4 2 3 1 2 2 2 | 7 2.3| _____________________________________________________________________________________________________________________| | HEMATOPOIETIC SYSTEM | | | |__________________________________________________________________________|____________| Lymph Node, Mandibular | + + + + + + + + + + | 10 | |__________________________________________________________________________|____________| Lymph Node, Mesenteric | M M + + + + + + + + | 8 | |__________________________________________________________________________|____________| Spleen | + + + + + + + + + + | 10 | |__________________________________________________________________________|____________| Thymus | + + + + + + + + + + | 10 | Atrophy | 4 4 3 | 3 3.7| Cyst | 1 1 1 | 3 1.0| Ectopic Parathyroid Gland | 1 | 1 1.0| Thrombosis | 2 | 1 2.0| _____________________________________________________________________________________________________________________| | INTEGUMENTARY SYSTEM | | | |__________________________________________________________________________|____________| Skin | + + + + + + | 6 | Epidermis, Hyperplasia | 3 | 1 3.0| _____________________________________________________________________________________________________________________| | MUSCULOSKELETAL SYSTEM | | | None | | | _____________________________________________________________________________________________________________________|____________| * : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade + : Tissue examined microscopically M : Missing tissue 1-4 : Lesion qualified as: X : Lesion present but not qualified A : Autolysis precludes examination 1) Minimal 3) Moderate I : Insufficient tissue BLANK : Not examined 2) Mild 4) Marked Page 3 NTP Experiment-Test: 97013-91 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09 Study Type: 26-39 WEEKS WATER DISINFECTION MODEL (DICHLOROACETIC ACID) Date: 12/05/03 Route: DOSED WATER Time: 09:40:06 __________________________________________________________________________________________________________________________________ | 1| 1| 2| 2| 2| 2| 2| 2| 0| 2| | | DAY ON TEST | 4| 2| 8| 8| 8| 8| 8| 8| 9| 8| | | | 1| 0| 2| 2| 2| 2| 2| 2| 4| 2| | | __________________________________________|__________________________________________________________________________| T (*) | | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | O | TGAC (FVB/N) HEMIZYGOUS FEMALE | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| | T | ANIMAL ID | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | A | 0 MG/L | 4| 4| 4| 4| 4| 4| 4| 4| 4| 5| | L | | 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| | | _____________________________________________________________________________________________________________________|____________| NERVOUS SYSTEM | | | None | | | _____________________________________________________________________________________________________________________| | RESPIRATORY SYSTEM | | | |__________________________________________________________________________|____________| Lung | + + + + + + + + + + | 10 | _____________________________________________________________________________________________________________________| | SPECIAL SENSES SYSTEM | | | None | | | _____________________________________________________________________________________________________________________| | URINARY SYSTEM | | | |__________________________________________________________________________|____________| Kidney | + + + + + + + + + + | 10 | Nephropathy | 1 1 1 | 3 1.0| Glomerulus, Inflammation, | | | Membranoproliferative | 3 3 2 | 3 2.7| Renal Tubule, Dilatation | 1 1 1 | 3 1.0| __________________________________________________________________________________________________________________________________ * : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade + : Tissue examined microscopically M : Missing tissue 1-4 : Lesion qualified as: X : Lesion present but not qualified A : Autolysis precludes examination 1) Minimal 3) Moderate I : Insufficient tissue BLANK : Not examined 2) Mild 4) Marked Page 4 NTP Experiment-Test: 97013-91 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09 Study Type: 26-39 WEEKS WATER DISINFECTION MODEL (DICHLOROACETIC ACID) Date: 12/05/03 Route: DOSED WATER Time: 09:40:06 __________________________________________________________________________________________________________________________________ | 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| | | DAY ON TEST | 8| 8| 8| 8| 8| 8| 8| 0| 8| 8| | | | 2| 2| 2| 2| 2| 2| 2| 0| 2| 2| | | __________________________________________|__________________________________________________________________________| T (*) | | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | O | TGAC (FVB/N) HEMIZYGOUS FEMALE | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| | T | ANIMAL ID | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | A | 500 MG/L | 5| 5| 5| 5| 5| 5| 5| 5| 5| 6| | L | | 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| | | _____________________________________________________________________________________________________________________|____________| ALIMENTARY SYSTEM | | | |__________________________________________________________________________|____________| Intestine Large, Colon | + + + + + + + + + + | 10 | |__________________________________________________________________________|____________| Intestine Large, Cecum | + + + + + + + + + + | 10 | |__________________________________________________________________________|____________| Intestine Small, Duodenum | + + + + + + + + + + | 10 | |__________________________________________________________________________|____________| Intestine Small, Jejunum | + + + + + + + + + + | 10 | |__________________________________________________________________________|____________| Intestine Small, Ileum | + + + + + + + + + + | 10 | |__________________________________________________________________________|____________| Liver | + + + + + + + + + + | 10 | Inflammation, Chronic Active | 1 1 1 1 1 1 1 1 1 1 | 10 1.0| Hepatocyte, Necrosis | 1 | 1 1.0| Hepatocyte, Vacuolization Cytoplasmic| 3 2 2 3 2 4 3 2 2 | 9 2.6| |__________________________________________________________________________|____________| Stomach, Forestomach | + + + + + + + + + + | 10 | Epithelium, Hyperkeratosis | 2 | 1 2.0| Epithelium, Hyperplasia | 2 | 1 2.0| |__________________________________________________________________________|____________| Tooth | + + | 2 | _____________________________________________________________________________________________________________________| | CARDIOVASCULAR SYSTEM | | | None | | | _____________________________________________________________________________________________________________________| | ENDOCRINE SYSTEM | | | |__________________________________________________________________________|____________| Adrenal Cortex | + + + + + + + + + + | 10 | Accessory Adrenal Cortical Nodule | 2 1 | 2 1.5| Subcapsular, Hyperplasia | 1 1 1 1 1 | 5 1.0| |__________________________________________________________________________|____________| Adrenal Medulla | + + + + + + + + + + | 10 | |__________________________________________________________________________|____________| Pituitary Gland | + + + + + + + + + + | 10 | _____________________________________________________________________________________________________________________|____________| * : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade + : Tissue examined microscopically M : Missing tissue 1-4 : Lesion qualified as: X : Lesion present but not qualified A : Autolysis precludes examination 1) Minimal 3) Moderate I : Insufficient tissue BLANK : Not examined 2) Mild 4) Marked Page 5 NTP Experiment-Test: 97013-91 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09 Study Type: 26-39 WEEKS WATER DISINFECTION MODEL (DICHLOROACETIC ACID) Date: 12/05/03 Route: DOSED WATER Time: 09:40:06 __________________________________________________________________________________________________________________________________ | 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| | | DAY ON TEST | 8| 8| 8| 8| 8| 8| 8| 0| 8| 8| | | | 2| 2| 2| 2| 2| 2| 2| 0| 2| 2| | | __________________________________________|__________________________________________________________________________| T (*) | | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | O | TGAC (FVB/N) HEMIZYGOUS FEMALE | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| | T | ANIMAL ID | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | A | 500 MG/L | 5| 5| 5| 5| 5| 5| 5| 5| 5| 6| | L | | 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| | | _____________________________________________________________________________________________________________________|____________| ENDOCRINE SYSTEM - cont | | | Pars Distalis, Cyst | 1 2 | 2 1.5| |__________________________________________________________________________|____________| Thyroid Gland | + + + + + + + + + + | 10 | Follicle, Degeneration | 1 1 1 1 1 1 | 6 1.0| _____________________________________________________________________________________________________________________| | GENERAL BODY SYSTEM | | | None | | | _____________________________________________________________________________________________________________________| | GENITAL SYSTEM | | | |__________________________________________________________________________|____________| Ovary | + + + + + + + + + + | 10 | Cyst | 2 2 2 2 2 2 2 | 7 2.0| Inflammation, Chronic Active | 3 | 1 3.0| |__________________________________________________________________________|____________| Oviduct | + | 1 | |__________________________________________________________________________|____________| Uterus | + + + + + + + + + + | 10 | Endometrium, Hyperplasia, Cystic | 2 2 2 2 2 3 2 1 2 | 9 2.0| _____________________________________________________________________________________________________________________| | HEMATOPOIETIC SYSTEM | | | |__________________________________________________________________________|____________| Lymph Node | + | 1 | |__________________________________________________________________________|____________| Lymph Node, Mandibular | + + + + + + + + + + | 10 | Hyperplasia, Lymphoid | 3 | 1 3.0| |__________________________________________________________________________|____________| Lymph Node, Mesenteric | + + + + + + + + + + | 10 | |__________________________________________________________________________|____________| Spleen | + + + + + + + + + + | 10 | Atrophy | 3 | 1 3.0| Hematopoietic Cell Proliferation | 2 | 1 2.0| |__________________________________________________________________________|____________| Thymus | + + + + + + + + + + | 10 | Atrophy | 3 | 1 3.0| _____________________________________________________________________________________________________________________|____________| * : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade + : Tissue examined microscopically M : Missing tissue 1-4 : Lesion qualified as: X : Lesion present but not qualified A : Autolysis precludes examination 1) Minimal 3) Moderate I : Insufficient tissue BLANK : Not examined 2) Mild 4) Marked Page 6 NTP Experiment-Test: 97013-91 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09 Study Type: 26-39 WEEKS WATER DISINFECTION MODEL (DICHLOROACETIC ACID) Date: 12/05/03 Route: DOSED WATER Time: 09:40:06 __________________________________________________________________________________________________________________________________ | 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| | | DAY ON TEST | 8| 8| 8| 8| 8| 8| 8| 0| 8| 8| | | | 2| 2| 2| 2| 2| 2| 2| 0| 2| 2| | | __________________________________________|__________________________________________________________________________| T (*) | | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | O | TGAC (FVB/N) HEMIZYGOUS FEMALE | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| | T | ANIMAL ID | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | A | 500 MG/L | 5| 5| 5| 5| 5| 5| 5| 5| 5| 6| | L | | 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| | | _____________________________________________________________________________________________________________________|____________| HEMATOPOIETIC SYSTEM - cont | | | Cyst | 2 1 1 2 | 4 1.5| _____________________________________________________________________________________________________________________| | INTEGUMENTARY SYSTEM | | | |__________________________________________________________________________|____________| Skin | + + + + + + + | 7 | _____________________________________________________________________________________________________________________| | MUSCULOSKELETAL SYSTEM | | | None | | | _____________________________________________________________________________________________________________________| | NERVOUS SYSTEM | | | None | | | _____________________________________________________________________________________________________________________| | RESPIRATORY SYSTEM | | | |__________________________________________________________________________|____________| Lung | + + + + + + + + + + | 10 | _____________________________________________________________________________________________________________________| | SPECIAL SENSES SYSTEM | | | None | | | _____________________________________________________________________________________________________________________| | URINARY SYSTEM | | | |__________________________________________________________________________|____________| Kidney | + + + + + + + + + + | 10 | Nephropathy | 1 1 1 1 1 | 5 1.0| Renal Tubule, Dilatation | 1 | 1 1.0| __________________________________________________________________________________________________________________________________ * : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade + : Tissue examined microscopically M : Missing tissue 1-4 : Lesion qualified as: X : Lesion present but not qualified A : Autolysis precludes examination 1) Minimal 3) Moderate I : Insufficient tissue BLANK : Not examined 2) Mild 4) Marked Page 7 NTP Experiment-Test: 97013-91 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09 Study Type: 26-39 WEEKS WATER DISINFECTION MODEL (DICHLOROACETIC ACID) Date: 12/05/03 Route: DOSED WATER Time: 09:40:06 __________________________________________________________________________________________________________________________________ | 2| 1| 2| 0| 2| 2| 2| 2| 1| 2| | | DAY ON TEST | 8| 8| 8| 7| 8| 8| 8| 8| 3| 8| | | | 2| 0| 2| 8| 2| 2| 2| 2| 9| 2| | | __________________________________________|__________________________________________________________________________| T (*) | | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | O | TGAC (FVB/N) HEMIZYGOUS FEMALE | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| | T | ANIMAL ID | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | A | 1000MG/L | 6| 6| 6| 6| 6| 6| 6| 6| 6| 7| | L | | 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| | | _____________________________________________________________________________________________________________________|____________| ALIMENTARY SYSTEM | | | |__________________________________________________________________________|____________| Intestine Large, Colon | + + + + + + + + + + | 10 | |__________________________________________________________________________|____________| Intestine Large, Cecum | + + + + + + + + + + | 10 | |__________________________________________________________________________|____________| Intestine Small, Duodenum | + + + + + + + + + + | 10 | |__________________________________________________________________________|____________| Intestine Small, Jejunum | + + + + + + + + + + | 10 | |__________________________________________________________________________|____________| Intestine Small, Ileum | + + + + + + + + + + | 10 | |__________________________________________________________________________|____________| Liver | + + + + + + + + + + | 10 | Inflammation, Chronic Active | 1 1 1 1 1 1 1 1 1 | 9 1.0| Hepatocyte, Necrosis | 1 | 1 1.0| Hepatocyte, Vacuolization Cytoplasmic| 4 2 3 2 3 3 3 4 2 | 9 2.9| |__________________________________________________________________________|____________| Stomach, Forestomach | + + + + + + + + + + | 10 | |__________________________________________________________________________|____________| Tooth | + + + | 3 | _____________________________________________________________________________________________________________________| | CARDIOVASCULAR SYSTEM | | | None | | | _____________________________________________________________________________________________________________________| | ENDOCRINE SYSTEM | | | |__________________________________________________________________________|____________| Adrenal Cortex | + + + + + + + + + + | 10 | Accessory Adrenal Cortical Nodule | 2 1 | 2 1.5| Subcapsular, Hyperplasia | 1 1 1 1 | 4 1.0| |__________________________________________________________________________|____________| Adrenal Medulla | + + + + + + + + + + | 10 | Mineralization | 1 | 1 1.0| |__________________________________________________________________________|____________| Pituitary Gland | + + + + + + + + + + | 10 | Pars Distalis, Cyst | 1 1 | 2 1.0| _____________________________________________________________________________________________________________________|____________| * : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade + : Tissue examined microscopically M : Missing tissue 1-4 : Lesion qualified as: X : Lesion present but not qualified A : Autolysis precludes examination 1) Minimal 3) Moderate I : Insufficient tissue BLANK : Not examined 2) Mild 4) Marked Page 8 NTP Experiment-Test: 97013-91 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09 Study Type: 26-39 WEEKS WATER DISINFECTION MODEL (DICHLOROACETIC ACID) Date: 12/05/03 Route: DOSED WATER Time: 09:40:06 __________________________________________________________________________________________________________________________________ | 2| 1| 2| 0| 2| 2| 2| 2| 1| 2| | | DAY ON TEST | 8| 8| 8| 7| 8| 8| 8| 8| 3| 8| | | | 2| 0| 2| 8| 2| 2| 2| 2| 9| 2| | | __________________________________________|__________________________________________________________________________| T (*) | | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | O | TGAC (FVB/N) HEMIZYGOUS FEMALE | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| | T | ANIMAL ID | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | A | 1000MG/L | 6| 6| 6| 6| 6| 6| 6| 6| 6| 7| | L | | 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| | | _____________________________________________________________________________________________________________________|____________| ENDOCRINE SYSTEM - cont | | | |__________________________________________________________________________|____________| Thyroid Gland | + + + + + + + + + + | 10 | Follicle, Degeneration | 1 1 1 1 1 | 5 1.0| _____________________________________________________________________________________________________________________| | GENERAL BODY SYSTEM | | | None | | | _____________________________________________________________________________________________________________________| | GENITAL SYSTEM | | | |__________________________________________________________________________|____________| Ovary | + + + + + + + + + + | 10 | Cyst | 2 2 2 2 | 4 2.0| |__________________________________________________________________________|____________| Uterus | + + + + + + + + + + | 10 | Endometrium, Hyperplasia, Cystic | 2 2 2 2 3 2 2 | 7 2.1| _____________________________________________________________________________________________________________________| | HEMATOPOIETIC SYSTEM | | | |__________________________________________________________________________|____________| Lymph Node, Mandibular | + + + + + + + + + + | 10 | Hyperplasia, Lymphoid | 2 | 1 2.0| |__________________________________________________________________________|____________| Lymph Node, Mesenteric | + + + + + + + + + + | 10 | |__________________________________________________________________________|____________| Spleen | + + + + + + + + + + | 10 | |__________________________________________________________________________|____________| Thymus | + M + + + + + + + + | 9 | Atrophy | 4 | 1 4.0| Cyst | 2 2 | 2 2.0| _____________________________________________________________________________________________________________________| | INTEGUMENTARY SYSTEM | | | |__________________________________________________________________________|____________| Skin | + + + + + + + | 7 | Hyperkeratosis | 2 | 1 2.0| Inflammation, Chronic Active | 2 | 1 2.0| Epidermis, Hyperplasia | 2 2 | 2 2.0| _____________________________________________________________________________________________________________________|____________| * : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade + : Tissue examined microscopically M : Missing tissue 1-4 : Lesion qualified as: X : Lesion present but not qualified A : Autolysis precludes examination 1) Minimal 3) Moderate I : Insufficient tissue BLANK : Not examined 2) Mild 4) Marked Page 9 NTP Experiment-Test: 97013-91 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09 Study Type: 26-39 WEEKS WATER DISINFECTION MODEL (DICHLOROACETIC ACID) Date: 12/05/03 Route: DOSED WATER Time: 09:40:06 __________________________________________________________________________________________________________________________________ | 2| 1| 2| 0| 2| 2| 2| 2| 1| 2| | | DAY ON TEST | 8| 8| 8| 7| 8| 8| 8| 8| 3| 8| | | | 2| 0| 2| 8| 2| 2| 2| 2| 9| 2| | | __________________________________________|__________________________________________________________________________| T (*) | | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | O | TGAC (FVB/N) HEMIZYGOUS FEMALE | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| | T | ANIMAL ID | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | A | 1000MG/L | 6| 6| 6| 6| 6| 6| 6| 6| 6| 7| | L | | 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| | | _____________________________________________________________________________________________________________________|____________| MUSCULOSKELETAL SYSTEM | | | |__________________________________________________________________________|____________| Bone | + | 1 | _____________________________________________________________________________________________________________________| | NERVOUS SYSTEM | | | None | | | _____________________________________________________________________________________________________________________| | RESPIRATORY SYSTEM | | | |__________________________________________________________________________|____________| Lung | + + + + + + + + + + | 10 | _____________________________________________________________________________________________________________________| | SPECIAL SENSES SYSTEM | | | None | | | _____________________________________________________________________________________________________________________| | URINARY SYSTEM | | | |__________________________________________________________________________|____________| Kidney | + + + + + + + + + + | 10 | Infarct | 3 | 1 3.0| Mineralization | 1 | 1 1.0| Nephropathy | 1 1 | 2 1.0| Glomerulus, Inflammation, | | | Membranoproliferative | 3 | 1 3.0| Renal Tubule, Dilatation | 1 1 | 2 1.0| __________________________________________________________________________________________________________________________________ * : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade + : Tissue examined microscopically M : Missing tissue 1-4 : Lesion qualified as: X : Lesion present but not qualified A : Autolysis precludes examination 1) Minimal 3) Moderate I : Insufficient tissue BLANK : Not examined 2) Mild 4) Marked Page 10 NTP Experiment-Test: 97013-91 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09 Study Type: 26-39 WEEKS WATER DISINFECTION MODEL (DICHLOROACETIC ACID) Date: 12/05/03 Route: DOSED WATER Time: 09:40:06 __________________________________________________________________________________________________________________________________ | 2| 2| 2| 2| 2| 2| 1| 0| 2| 2| | | DAY ON TEST | 8| 8| 8| 8| 8| 8| 0| 8| 8| 8| | | | 2| 2| 2| 2| 2| 2| 8| 9| 2| 2| | | __________________________________________|__________________________________________________________________________| T (*) | | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | O | TGAC (FVB/N) HEMIZYGOUS FEMALE | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| | T | ANIMAL ID | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | A | 2000MG/L | 7| 7| 7| 7| 7| 7| 7| 7| 7| 8| | L | | 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| | | _____________________________________________________________________________________________________________________|____________| ALIMENTARY SYSTEM | | | |__________________________________________________________________________|____________| Intestine Large, Colon | + + + + + + + + + + | 10 | |__________________________________________________________________________|____________| Intestine Large, Cecum | + + + + + + + + + + | 10 | |__________________________________________________________________________|____________| Intestine Small, Duodenum | + + + + + + + + + + | 10 | |__________________________________________________________________________|____________| Intestine Small, Jejunum | + + + + + + + + + + | 10 | |__________________________________________________________________________|____________| Intestine Small, Ileum | + + + + + + + + + + | 10 | |__________________________________________________________________________|____________| Liver | + + + + + + + + + + | 10 | Inflammation, Chronic Active | 1 1 1 1 1 1 1 1 | 8 1.0| Hepatocyte, Fatty Change | 1 | 1 1.0| Hepatocyte, Necrosis | 1 1 1 1 | 4 1.0| Hepatocyte, Vacuolization Cytoplasmic| 3 3 4 3 3 4 1 2 3 4 | 10 3.0| |__________________________________________________________________________|____________| Pancreas | + | 1 | |__________________________________________________________________________|____________| Stomach, Forestomach | + + + + + + + + + + | 10 | |__________________________________________________________________________|____________| Tooth | + + + | 3 | _____________________________________________________________________________________________________________________| | CARDIOVASCULAR SYSTEM | | | None | | | _____________________________________________________________________________________________________________________| | ENDOCRINE SYSTEM | | | |__________________________________________________________________________|____________| Adrenal Cortex | + + + + + + + + + + | 10 | Accessory Adrenal Cortical Nodule | 2 1 1 | 3 1.3| Subcapsular, Hyperplasia | 1 1 1 1 1 1 1 1 | 8 1.0| |__________________________________________________________________________|____________| Adrenal Medulla | + + + + + + + + + + | 10 | |__________________________________________________________________________|____________| _____________________________________________________________________________________________________________________|____________| * : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade + : Tissue examined microscopically M : Missing tissue 1-4 : Lesion qualified as: X : Lesion present but not qualified A : Autolysis precludes examination 1) Minimal 3) Moderate I : Insufficient tissue BLANK : Not examined 2) Mild 4) Marked Page 11 NTP Experiment-Test: 97013-91 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09 Study Type: 26-39 WEEKS WATER DISINFECTION MODEL (DICHLOROACETIC ACID) Date: 12/05/03 Route: DOSED WATER Time: 09:40:06 __________________________________________________________________________________________________________________________________ | 2| 2| 2| 2| 2| 2| 1| 0| 2| 2| | | DAY ON TEST | 8| 8| 8| 8| 8| 8| 0| 8| 8| 8| | | | 2| 2| 2| 2| 2| 2| 8| 9| 2| 2| | | __________________________________________|__________________________________________________________________________| T (*) | | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | O | TGAC (FVB/N) HEMIZYGOUS FEMALE | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| | T | ANIMAL ID | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | A | 2000MG/L | 7| 7| 7| 7| 7| 7| 7| 7| 7| 8| | L | | 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| | | _____________________________________________________________________________________________________________________|____________| ENDOCRINE SYSTEM - cont | | | Pituitary Gland | + + + + + + + + + + | 10 | Pars Distalis, Cyst | 1 1 | 2 1.0| |__________________________________________________________________________|____________| Thyroid Gland | + + + + + + + + + + | 10 | Ectopic Thymus | 2 | 1 2.0| Follicle, Degeneration | 1 1 1 1 1 | 5 1.0| _____________________________________________________________________________________________________________________| | GENERAL BODY SYSTEM | | | None | | | _____________________________________________________________________________________________________________________| | GENITAL SYSTEM | | | |__________________________________________________________________________|____________| Ovary | + + + + + + + + + + | 10 | Cyst | 2 | 1 2.0| |__________________________________________________________________________|____________| Uterus | + + + + + + + + + + | 10 | Endometrium, Hyperplasia, Cystic | 2 2 1 1 2 1 3 | 7 1.7| _____________________________________________________________________________________________________________________| | HEMATOPOIETIC SYSTEM | | | |__________________________________________________________________________|____________| Lymph Node | + | 1 | |__________________________________________________________________________|____________| Lymph Node, Mandibular | + + + + + + + + + + | 10 | Hyperplasia, Lymphoid | 2 | 1 2.0| |__________________________________________________________________________|____________| Lymph Node, Mesenteric | + + + + + + + + + + | 10 | |__________________________________________________________________________|____________| Spleen | + + + + + + + + + + | 10 | Hematopoietic Cell Proliferation | 2 | 1 2.0| |__________________________________________________________________________|____________| Thymus | + + + + + + + + + + | 10 | Atrophy | 3 | 1 3.0| Cyst | 2 1 1 2 1 | 5 1.4| Thymocyte, Necrosis | 1 | 1 1.0| _____________________________________________________________________________________________________________________|____________| * : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade + : Tissue examined microscopically M : Missing tissue 1-4 : Lesion qualified as: X : Lesion present but not qualified A : Autolysis precludes examination 1) Minimal 3) Moderate I : Insufficient tissue BLANK : Not examined 2) Mild 4) Marked Page 12 NTP Experiment-Test: 97013-91 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09 Study Type: 26-39 WEEKS WATER DISINFECTION MODEL (DICHLOROACETIC ACID) Date: 12/05/03 Route: DOSED WATER Time: 09:40:06 __________________________________________________________________________________________________________________________________ | 2| 2| 2| 2| 2| 2| 1| 0| 2| 2| | | DAY ON TEST | 8| 8| 8| 8| 8| 8| 0| 8| 8| 8| | | | 2| 2| 2| 2| 2| 2| 8| 9| 2| 2| | | __________________________________________|__________________________________________________________________________| T (*) | | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | O | TGAC (FVB/N) HEMIZYGOUS FEMALE | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| | T | ANIMAL ID | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | A | 2000MG/L | 7| 7| 7| 7| 7| 7| 7| 7| 7| 8| | L | | 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| | | _____________________________________________________________________________________________________________________|____________| INTEGUMENTARY SYSTEM | | | |__________________________________________________________________________|____________| Skin | + + + + + + + | 7 | _____________________________________________________________________________________________________________________| | MUSCULOSKELETAL SYSTEM | | | None | | | _____________________________________________________________________________________________________________________| | NERVOUS SYSTEM | | | None | | | _____________________________________________________________________________________________________________________| | RESPIRATORY SYSTEM | | | |__________________________________________________________________________|____________| Lung | + + + + + + + + + + | 10 | _____________________________________________________________________________________________________________________| | SPECIAL SENSES SYSTEM | | | None | | | _____________________________________________________________________________________________________________________| | URINARY SYSTEM | | | |__________________________________________________________________________|____________| Kidney | + + + + + + + + + + | 10 | Nephropathy | 1 1 1 1 1 1 1 | 7 1.0| Glomerulus, Inflammation, | | | Membranoproliferative | 2 | 1 2.0| __________________________________________________________________________________________________________________________________ * : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade + : Tissue examined microscopically M : Missing tissue 1-4 : Lesion qualified as: X : Lesion present but not qualified A : Autolysis precludes examination 1) Minimal 3) Moderate I : Insufficient tissue BLANK : Not examined 2) Mild 4) Marked Page 13 NTP Experiment-Test: 97013-91 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09 Study Type: 26-39 WEEKS WATER DISINFECTION MODEL (DICHLOROACETIC ACID) Date: 12/05/03 Route: DOSED WATER Time: 09:40:06 __________________________________________________________________________________________________________________________________ | 2| 2| 2| 2| 2| 2| 0| 2| 2| 2| | | DAY ON TEST | 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| | | | 1| 1| 1| 1| 1| 1| 7| 1| 1| 1| | | __________________________________________|__________________________________________________________________________| T (*) | | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | O | TGAC (FVB/N) HEMIZYGOUS MALE | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| | T | ANIMAL ID | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | A | 0 MG/L | 0| 0| 0| 0| 0| 0| 0| 0| 0| 1| | L | | 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| | | _____________________________________________________________________________________________________________________|____________| ALIMENTARY SYSTEM | | | |__________________________________________________________________________|____________| Intestine Large, Colon | + + + + + + + + + + | 10 | |__________________________________________________________________________|____________| Intestine Large, Cecum | + + + + + + + + + + | 10 | |__________________________________________________________________________|____________| Intestine Small, Duodenum | + + + + + + + + + + | 10 | |__________________________________________________________________________|____________| Intestine Small, Jejunum | + + + + + + + + + + | 10 | |__________________________________________________________________________|____________| Intestine Small, Ileum | + + + + + + + + + + | 10 | |__________________________________________________________________________|____________| Liver | + + + + + + + + + + | 10 | Inflammation, Chronic Active | 1 1 2 1 1 3 1 1 1 | 9 1.3| Hepatocyte, Necrosis | 3 | 1 3.0| Hepatocyte, Vacuolization Cytoplasmic| 2 2 2 2 2 2 2 2 2 | 9 2.0| |__________________________________________________________________________|____________| Mesentery | + | 1 | Fat, Necrosis | 4 | 1 4.0| |__________________________________________________________________________|____________| Stomach, Forestomach | + + + + + + + + + + | 10 | Epithelium, Hyperplasia | 2 2 1 | 3 1.7| |__________________________________________________________________________|____________| Tooth | + + | 2 | _____________________________________________________________________________________________________________________| | CARDIOVASCULAR SYSTEM | | | None | | | _____________________________________________________________________________________________________________________| | ENDOCRINE SYSTEM | | | |__________________________________________________________________________|____________| Adrenal Cortex | + + + + + + + + + + | 10 | Accessory Adrenal Cortical Nodule | 1 | 1 1.0| Hematopoietic Cell Proliferation | 2 | 1 2.0| Hypertrophy | 2 2 2 1 2 2 3 3 | 8 2.1| Subcapsular, Hyperplasia | 1 2 | 2 1.5| _____________________________________________________________________________________________________________________|____________| * : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade + : Tissue examined microscopically M : Missing tissue 1-4 : Lesion qualified as: X : Lesion present but not qualified A : Autolysis precludes examination 1) Minimal 3) Moderate I : Insufficient tissue BLANK : Not examined 2) Mild 4) Marked Page 14 NTP Experiment-Test: 97013-91 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09 Study Type: 26-39 WEEKS WATER DISINFECTION MODEL (DICHLOROACETIC ACID) Date: 12/05/03 Route: DOSED WATER Time: 09:40:06 __________________________________________________________________________________________________________________________________ | 2| 2| 2| 2| 2| 2| 0| 2| 2| 2| | | DAY ON TEST | 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| | | | 1| 1| 1| 1| 1| 1| 7| 1| 1| 1| | | __________________________________________|__________________________________________________________________________| T (*) | | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | O | TGAC (FVB/N) HEMIZYGOUS MALE | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| | T | ANIMAL ID | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | A | 0 MG/L | 0| 0| 0| 0| 0| 0| 0| 0| 0| 1| | L | | 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| | | _____________________________________________________________________________________________________________________|____________| ENDOCRINE SYSTEM - cont | | | |__________________________________________________________________________|____________| Adrenal Medulla | + + + + + + + + + + | 10 | |__________________________________________________________________________|____________| Pituitary Gland | + + + + + + + + + + | 10 | |__________________________________________________________________________|____________| Thyroid Gland | + + + + + + + + + + | 10 | Infiltration Cellular, Lymphocyte | 1 | 1 1.0| Follicle, Degeneration | 1 1 1 | 3 1.0| _____________________________________________________________________________________________________________________| | GENERAL BODY SYSTEM | | | None | | | _____________________________________________________________________________________________________________________| | GENITAL SYSTEM | | | |__________________________________________________________________________|____________| Epididymis | + + + + + + + + + + | 10 | Inflammation, Chronic Active | 2 | 1 2.0| |__________________________________________________________________________|____________| Preputial Gland | + + | 2 | Inflammation, Chronic Active | 4 | 1 4.0| Duct, Ectasia | 3 2 | 2 2.5| |__________________________________________________________________________|____________| Seminal Vesicle | + | 1 | Inflammation, Chronic Active | 4 | 1 4.0| |__________________________________________________________________________|____________| Testes | + + + + + + + + + + | 10 | _____________________________________________________________________________________________________________________| | HEMATOPOIETIC SYSTEM | | | |__________________________________________________________________________|____________| Lymph Node, Mandibular | + + + + + + + + + + | 10 | |__________________________________________________________________________|____________| Lymph Node, Mesenteric | + + + + + + + + + + | 10 | |__________________________________________________________________________|____________| Spleen | + + + + + + + + + + | 10 | Hematopoietic Cell Proliferation | 3 | 1 3.0| _____________________________________________________________________________________________________________________|____________| * : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade + : Tissue examined microscopically M : Missing tissue 1-4 : Lesion qualified as: X : Lesion present but not qualified A : Autolysis precludes examination 1) Minimal 3) Moderate I : Insufficient tissue BLANK : Not examined 2) Mild 4) Marked Page 15 NTP Experiment-Test: 97013-91 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09 Study Type: 26-39 WEEKS WATER DISINFECTION MODEL (DICHLOROACETIC ACID) Date: 12/05/03 Route: DOSED WATER Time: 09:40:06 __________________________________________________________________________________________________________________________________ | 2| 2| 2| 2| 2| 2| 0| 2| 2| 2| | | DAY ON TEST | 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| | | | 1| 1| 1| 1| 1| 1| 7| 1| 1| 1| | | __________________________________________|__________________________________________________________________________| T (*) | | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | O | TGAC (FVB/N) HEMIZYGOUS MALE | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| | T | ANIMAL ID | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | A | 0 MG/L | 0| 0| 0| 0| 0| 0| 0| 0| 0| 1| | L | | 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| | | _____________________________________________________________________________________________________________________|____________| HEMATOPOIETIC SYSTEM - cont | | | Necrosis | 3 | 1 3.0| |__________________________________________________________________________|____________| Thymus | + + + + + + + + + + | 10 | Atrophy | 3 4 | 2 3.5| Cyst | 2 1 | 2 1.5| _____________________________________________________________________________________________________________________| | INTEGUMENTARY SYSTEM | | | |__________________________________________________________________________|____________| Skin | + + + + + + + + + | 9 | Epidermis, Hyperplasia | 2 3 3 3 4 | 5 3.0| _____________________________________________________________________________________________________________________| | MUSCULOSKELETAL SYSTEM | | | None | | | _____________________________________________________________________________________________________________________| | NERVOUS SYSTEM | | | None | | | _____________________________________________________________________________________________________________________| | RESPIRATORY SYSTEM | | | |__________________________________________________________________________|____________| Lung | + + + + + + + + + + | 10 | Hemorrhage | 2 | 1 2.0| Infiltration Cellular, | | | Polymorphonuclear | 4 | 1 4.0| Inflammation, Chronic Active | 2 1 | 2 1.5| _____________________________________________________________________________________________________________________| | SPECIAL SENSES SYSTEM | | | None | | | _____________________________________________________________________________________________________________________| | URINARY SYSTEM | | | |__________________________________________________________________________|____________| Kidney | + + + + + + + + + + | 10 | Inflammation, Chronic Active | 4 | 1 4.0| Mineralization | 1 | 1 1.0| Necrosis | 3 | 1 3.0| _____________________________________________________________________________________________________________________|____________| * : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade + : Tissue examined microscopically M : Missing tissue 1-4 : Lesion qualified as: X : Lesion present but not qualified A : Autolysis precludes examination 1) Minimal 3) Moderate I : Insufficient tissue BLANK : Not examined 2) Mild 4) Marked Page 16 NTP Experiment-Test: 97013-91 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09 Study Type: 26-39 WEEKS WATER DISINFECTION MODEL (DICHLOROACETIC ACID) Date: 12/05/03 Route: DOSED WATER Time: 09:40:06 __________________________________________________________________________________________________________________________________ | 2| 2| 2| 2| 2| 2| 0| 2| 2| 2| | | DAY ON TEST | 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| | | | 1| 1| 1| 1| 1| 1| 7| 1| 1| 1| | | __________________________________________|__________________________________________________________________________| T (*) | | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | O | TGAC (FVB/N) HEMIZYGOUS MALE | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| | T | ANIMAL ID | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | A | 0 MG/L | 0| 0| 0| 0| 0| 0| 0| 0| 0| 1| | L | | 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| | | _____________________________________________________________________________________________________________________|____________| URINARY SYSTEM - cont | | | Nephropathy | 1 1 1 1 1 1 1 1 1 | 9 1.0| Renal Tubule, Dilatation | 2 1 1 1 | 4 1.3| __________________________________________________________________________________________________________________________________ * : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade + : Tissue examined microscopically M : Missing tissue 1-4 : Lesion qualified as: X : Lesion present but not qualified A : Autolysis precludes examination 1) Minimal 3) Moderate I : Insufficient tissue BLANK : Not examined 2) Mild 4) Marked Page 17 NTP Experiment-Test: 97013-91 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09 Study Type: 26-39 WEEKS WATER DISINFECTION MODEL (DICHLOROACETIC ACID) Date: 12/05/03 Route: DOSED WATER Time: 09:40:06 __________________________________________________________________________________________________________________________________ | 1| 2| 2| 2| 2| 2| 2| 2| 2| 2| | | DAY ON TEST | 5| 8| 8| 8| 8| 8| 8| 8| 8| 8| | | | 0| 1| 1| 1| 1| 1| 1| 1| 1| 1| | | __________________________________________|__________________________________________________________________________| T (*) | | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | O | TGAC (FVB/N) HEMIZYGOUS MALE | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| | T | ANIMAL ID | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | A | 500 MG/L | 1| 1| 1| 1| 1| 1| 1| 1| 1| 2| | L | | 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| | | _____________________________________________________________________________________________________________________|____________| ALIMENTARY SYSTEM | | | |__________________________________________________________________________|____________| Intestine Large, Colon | + + + + + + + + + + | 10 | |__________________________________________________________________________|____________| Intestine Large, Cecum | + + + + + + + + + + | 10 | |__________________________________________________________________________|____________| Intestine Small, Duodenum | + + + + + + + + + + | 10 | |__________________________________________________________________________|____________| Intestine Small, Jejunum | + + + + + + + + + + | 10 | |__________________________________________________________________________|____________| Intestine Small, Ileum | + + + + + + + + + + | 10 | |__________________________________________________________________________|____________| Liver | + + + + + + + + + + | 10 | Hematopoietic Cell Proliferation | 2 | 1 2.0| Inflammation, Acute | 2 | 1 2.0| Inflammation, Chronic Active | 1 1 1 1 1 1 1 | 7 1.0| Hepatocyte, Necrosis | 1 | 1 1.0| Hepatocyte, Vacuolization Cytoplasmic| 2 2 3 1 2 3 2 2 3 3 | 10 2.3| |__________________________________________________________________________|____________| Stomach, Forestomach | + + + + + + + + + + | 10 | |__________________________________________________________________________|____________| Tooth | + | 1 | _____________________________________________________________________________________________________________________| | CARDIOVASCULAR SYSTEM | | | None | | | _____________________________________________________________________________________________________________________| | ENDOCRINE SYSTEM | | | |__________________________________________________________________________|____________| Adrenal Cortex | + + + + + + + + + + | 10 | Accessory Adrenal Cortical Nodule | 2 | 1 2.0| Hematopoietic Cell Proliferation | 1 | 1 1.0| Hypertrophy | 1 1 1 3 2 1 | 6 1.5| Subcapsular, Hyperplasia | 1 | 1 1.0| |__________________________________________________________________________|____________| Adrenal Medulla | + + + + + + + + + + | 10 | _____________________________________________________________________________________________________________________|____________| * : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade + : Tissue examined microscopically M : Missing tissue 1-4 : Lesion qualified as: X : Lesion present but not qualified A : Autolysis precludes examination 1) Minimal 3) Moderate I : Insufficient tissue BLANK : Not examined 2) Mild 4) Marked Page 18 NTP Experiment-Test: 97013-91 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09 Study Type: 26-39 WEEKS WATER DISINFECTION MODEL (DICHLOROACETIC ACID) Date: 12/05/03 Route: DOSED WATER Time: 09:40:06 __________________________________________________________________________________________________________________________________ | 1| 2| 2| 2| 2| 2| 2| 2| 2| 2| | | DAY ON TEST | 5| 8| 8| 8| 8| 8| 8| 8| 8| 8| | | | 0| 1| 1| 1| 1| 1| 1| 1| 1| 1| | | __________________________________________|__________________________________________________________________________| T (*) | | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | O | TGAC (FVB/N) HEMIZYGOUS MALE | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| | T | ANIMAL ID | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | A | 500 MG/L | 1| 1| 1| 1| 1| 1| 1| 1| 1| 2| | L | | 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| | | _____________________________________________________________________________________________________________________|____________| ENDOCRINE SYSTEM - cont | | | |__________________________________________________________________________|____________| Pituitary Gland | + + + + + + + + + + | 10 | Pars Distalis, Cyst | 1 1 | 2 1.0| |__________________________________________________________________________|____________| Thyroid Gland | + + + + + + + + + + | 10 | Infiltration Cellular, Lymphocyte | 1 | 1 1.0| Follicle, Degeneration | 1 1 1 2 1 1 1 1 1 | 9 1.1| _____________________________________________________________________________________________________________________| | GENERAL BODY SYSTEM | | | None | | | _____________________________________________________________________________________________________________________| | GENITAL SYSTEM | | | |__________________________________________________________________________|____________| Epididymis | + + + + + + + + + + | 10 | Degeneration | 4 | 1 4.0| |__________________________________________________________________________|____________| Preputial Gland | + + + + | 4 | Duct, Ectasia | 2 3 2 2 | 4 2.3| |__________________________________________________________________________|____________| Seminal Vesicle | + | 1 | Inflammation, Suppurative | 4 | 1 4.0| |__________________________________________________________________________|____________| Testes | + + + + + + + + + + | 10 | Germinal Epithelium, Degeneration | 3 | 1 3.0| _____________________________________________________________________________________________________________________| | HEMATOPOIETIC SYSTEM | | | |__________________________________________________________________________|____________| Lymph Node | + | 1 | Lumbar, Hematopoietic Cell | | | Proliferation | 1 | 1 1.0| Lumbar, Hyperplasia, Lymphoid | 2 | 1 2.0| Mediastinal, Hematopoietic Cell | | | Proliferation | 1 | 1 1.0| Mediastinal, Hyperplasia, Lymphoid | 2 | 1 2.0| _____________________________________________________________________________________________________________________|____________| * : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade + : Tissue examined microscopically M : Missing tissue 1-4 : Lesion qualified as: X : Lesion present but not qualified A : Autolysis precludes examination 1) Minimal 3) Moderate I : Insufficient tissue BLANK : Not examined 2) Mild 4) Marked Page 19 NTP Experiment-Test: 97013-91 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09 Study Type: 26-39 WEEKS WATER DISINFECTION MODEL (DICHLOROACETIC ACID) Date: 12/05/03 Route: DOSED WATER Time: 09:40:06 __________________________________________________________________________________________________________________________________ | 1| 2| 2| 2| 2| 2| 2| 2| 2| 2| | | DAY ON TEST | 5| 8| 8| 8| 8| 8| 8| 8| 8| 8| | | | 0| 1| 1| 1| 1| 1| 1| 1| 1| 1| | | __________________________________________|__________________________________________________________________________| T (*) | | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | O | TGAC (FVB/N) HEMIZYGOUS MALE | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| | T | ANIMAL ID | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | A | 500 MG/L | 1| 1| 1| 1| 1| 1| 1| 1| 1| 2| | L | | 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| | | _____________________________________________________________________________________________________________________|____________| HEMATOPOIETIC SYSTEM - cont | | | Renal, Hematopoietic Cell | | | Proliferation | 1 | 1 1.0| Renal, Hyperplasia, Lymphoid | 2 | 1 2.0| |__________________________________________________________________________|____________| Lymph Node, Mandibular | + + + + + + + + + + | 10 | Hyperplasia, Lymphoid | 2 | 1 2.0| |__________________________________________________________________________|____________| Lymph Node, Mesenteric | + + + + + + + + + + | 10 | |__________________________________________________________________________|____________| Spleen | + + + + + + + + + + | 10 | Hematopoietic Cell Proliferation | 3 | 1 3.0| |__________________________________________________________________________|____________| Thymus | + + + + + + + + + + | 10 | Atrophy | 2 | 1 2.0| Cyst | 1 1 2 | 3 1.3| _____________________________________________________________________________________________________________________| | INTEGUMENTARY SYSTEM | | | |__________________________________________________________________________|____________| Skin | + + + + + + + + + | 9 | Epidermis, Hyperplasia | 2 3 3 2 | 4 2.5| _____________________________________________________________________________________________________________________| | MUSCULOSKELETAL SYSTEM | | | None | | | _____________________________________________________________________________________________________________________| | NERVOUS SYSTEM | | | None | | | _____________________________________________________________________________________________________________________| | RESPIRATORY SYSTEM | | | |__________________________________________________________________________|____________| Lung | + + + + + + + + + + | 10 | Inflammation, Chronic Active | 2 | 1 2.0| Alveolar Epithelium, Hyperplasia | 3 | 1 3.0| _____________________________________________________________________________________________________________________| | SPECIAL SENSES SYSTEM | | | None | | | _____________________________________________________________________________________________________________________|____________| * : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade + : Tissue examined microscopically M : Missing tissue 1-4 : Lesion qualified as: X : Lesion present but not qualified A : Autolysis precludes examination 1) Minimal 3) Moderate I : Insufficient tissue BLANK : Not examined 2) Mild 4) Marked Page 20 NTP Experiment-Test: 97013-91 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09 Study Type: 26-39 WEEKS WATER DISINFECTION MODEL (DICHLOROACETIC ACID) Date: 12/05/03 Route: DOSED WATER Time: 09:40:06 __________________________________________________________________________________________________________________________________ | 1| 2| 2| 2| 2| 2| 2| 2| 2| 2| | | DAY ON TEST | 5| 8| 8| 8| 8| 8| 8| 8| 8| 8| | | | 0| 1| 1| 1| 1| 1| 1| 1| 1| 1| | | __________________________________________|__________________________________________________________________________| T (*) | | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | O | TGAC (FVB/N) HEMIZYGOUS MALE | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| | T | ANIMAL ID | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | A | 500 MG/L | 1| 1| 1| 1| 1| 1| 1| 1| 1| 2| | L | | 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| | | _____________________________________________________________________________________________________________________|____________| URINARY SYSTEM | | | |__________________________________________________________________________|____________| Kidney | + + + + + + + + + + | 10 | Infarct | 4 | 1 4.0| Nephropathy | 1 1 2 1 2 1 1 1 | 8 1.3| Pelvis, Inflammation, Chronic | 2 | 1 2.0| Renal Tubule, Dilatation | 2 2 1 2 1 2 | 6 1.7| Renal Tubule, Nephropathy | 1 | 1 1.0| __________________________________________________________________________________________________________________________________ * : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade + : Tissue examined microscopically M : Missing tissue 1-4 : Lesion qualified as: X : Lesion present but not qualified A : Autolysis precludes examination 1) Minimal 3) Moderate I : Insufficient tissue BLANK : Not examined 2) Mild 4) Marked Page 21 NTP Experiment-Test: 97013-91 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09 Study Type: 26-39 WEEKS WATER DISINFECTION MODEL (DICHLOROACETIC ACID) Date: 12/05/03 Route: DOSED WATER Time: 09:40:06 __________________________________________________________________________________________________________________________________ | 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| | | DAY ON TEST | 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| | | | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| | | __________________________________________|__________________________________________________________________________| T (*) | | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | O | TGAC (FVB/N) HEMIZYGOUS MALE | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| | T | ANIMAL ID | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | A | 1000MG/L | 2| 2| 2| 2| 2| 2| 2| 2| 2| 3| | L | | 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| | | _____________________________________________________________________________________________________________________|____________| ALIMENTARY SYSTEM | | | |__________________________________________________________________________|____________| Intestine Large, Colon | + + + + + + + + + + | 10 | |__________________________________________________________________________|____________| Intestine Large, Cecum | + + + + + + + + + + | 10 | |__________________________________________________________________________|____________| Intestine Small, Duodenum | + + + + + + + + + + | 10 | |__________________________________________________________________________|____________| Intestine Small, Jejunum | + + + + + + + + + + | 10 | |__________________________________________________________________________|____________| Intestine Small, Ileum | + + + + + + + + + + | 10 | |__________________________________________________________________________|____________| Liver | + + + + + + + + + + | 10 | Inflammation, Acute | 2 | 1 2.0| Inflammation, Chronic Active | 1 1 1 1 1 | 5 1.0| Hepatocyte, Necrosis | 1 | 1 1.0| Hepatocyte, Vacuolization Cytoplasmic| 3 3 3 3 3 3 4 3 4 | 9 3.2| |__________________________________________________________________________|____________| Mesentery | + + + | 3 | Fat, Fibrosis | 2 2 | 2 2.0| Fat, Inflammation, Chronic Active | 2 | 1 2.0| Fat, Necrosis | 3 4 4 | 3 3.7| |__________________________________________________________________________|____________| Stomach, Forestomach | + + + + + + + + + + | 10 | |__________________________________________________________________________|____________| Tooth | + | 1 | _____________________________________________________________________________________________________________________| | CARDIOVASCULAR SYSTEM | | | None | | | _____________________________________________________________________________________________________________________| | ENDOCRINE SYSTEM | | | |__________________________________________________________________________|____________| Adrenal Cortex | + + + + + + + + + + | 10 | Atypia Cellular | 1 | 1 1.0| Hypertrophy | 3 3 2 3 2 2 3 2 1 | 9 2.3| _____________________________________________________________________________________________________________________|____________| * : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade + : Tissue examined microscopically M : Missing tissue 1-4 : Lesion qualified as: X : Lesion present but not qualified A : Autolysis precludes examination 1) Minimal 3) Moderate I : Insufficient tissue BLANK : Not examined 2) Mild 4) Marked Page 22 NTP Experiment-Test: 97013-91 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09 Study Type: 26-39 WEEKS WATER DISINFECTION MODEL (DICHLOROACETIC ACID) Date: 12/05/03 Route: DOSED WATER Time: 09:40:06 __________________________________________________________________________________________________________________________________ | 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| | | DAY ON TEST | 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| | | | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| | | __________________________________________|__________________________________________________________________________| T (*) | | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | O | TGAC (FVB/N) HEMIZYGOUS MALE | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| | T | ANIMAL ID | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | A | 1000MG/L | 2| 2| 2| 2| 2| 2| 2| 2| 2| 3| | L | | 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| | | _____________________________________________________________________________________________________________________|____________| ENDOCRINE SYSTEM - cont | | | Subcapsular, Hyperplasia | 1 | 1 1.0| |__________________________________________________________________________|____________| Adrenal Medulla | + + + + + + + + + + | 10 | |__________________________________________________________________________|____________| Pituitary Gland | + + + + + + + + + + | 10 | Pars Distalis, Cyst | 1 | 1 1.0| |__________________________________________________________________________|____________| Thyroid Gland | + + + + + + + + + + | 10 | Ectopic Thymus | 1 | 1 1.0| Follicle, Degeneration | 2 1 1 1 1 | 5 1.2| _____________________________________________________________________________________________________________________| | GENERAL BODY SYSTEM | | | None | | | _____________________________________________________________________________________________________________________| | GENITAL SYSTEM | | | |__________________________________________________________________________|____________| Epididymis | + + + + + + + + + + | 10 | Degeneration | 4 | 1 4.0| |__________________________________________________________________________|____________| Preputial Gland | + + | 2 | Duct, Ectasia | 2 2 | 2 2.0| |__________________________________________________________________________|____________| Testes | + + + + + + + + + + | 10 | Cyst | 2 | 1 2.0| Germinal Epithelium, Degeneration | 3 | 1 3.0| Interstitial Cell, Hyperplasia | 2 | 1 2.0| _____________________________________________________________________________________________________________________| | HEMATOPOIETIC SYSTEM | | | |__________________________________________________________________________|____________| Lymph Node | + + | 2 | Mediastinal, Infiltration Cellular, | | | Mast Cell | 3 | 1 3.0| Mediastinal, Infiltration Cellular, | | | Histiocyte | 2 | 1 2.0| _____________________________________________________________________________________________________________________|____________| * : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade + : Tissue examined microscopically M : Missing tissue 1-4 : Lesion qualified as: X : Lesion present but not qualified A : Autolysis precludes examination 1) Minimal 3) Moderate I : Insufficient tissue BLANK : Not examined 2) Mild 4) Marked Page 23 NTP Experiment-Test: 97013-91 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09 Study Type: 26-39 WEEKS WATER DISINFECTION MODEL (DICHLOROACETIC ACID) Date: 12/05/03 Route: DOSED WATER Time: 09:40:06 __________________________________________________________________________________________________________________________________ | 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| | | DAY ON TEST | 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| | | | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| | | __________________________________________|__________________________________________________________________________| T (*) | | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | O | TGAC (FVB/N) HEMIZYGOUS MALE | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| | T | ANIMAL ID | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | A | 1000MG/L | 2| 2| 2| 2| 2| 2| 2| 2| 2| 3| | L | | 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| | | _____________________________________________________________________________________________________________________|____________| HEMATOPOIETIC SYSTEM - cont | | | |__________________________________________________________________________|____________| Lymph Node, Mandibular | + + + + + + + + + + | 10 | Hyperplasia, Lymphoid | 2 | 1 2.0| |__________________________________________________________________________|____________| Lymph Node, Mesenteric | + + + + + + + + + + | 10 | |__________________________________________________________________________|____________| Spleen | + + + + + + + + + + | 10 | |__________________________________________________________________________|____________| Thymus | + + + M + + + + + + | 9 | Atrophy | 1 | 1 1.0| Cyst | 1 1 1 2 | 4 1.3| Ectopic Parathyroid Gland | 1 1 | 2 1.0| _____________________________________________________________________________________________________________________| | INTEGUMENTARY SYSTEM | | | |__________________________________________________________________________|____________| Skin | + + + + + + + + + | 9 | Inflammation, Chronic Active | 2 | 1 2.0| _____________________________________________________________________________________________________________________| | MUSCULOSKELETAL SYSTEM | | | None | | | _____________________________________________________________________________________________________________________| | NERVOUS SYSTEM | | | None | | | _____________________________________________________________________________________________________________________| | RESPIRATORY SYSTEM | | | |__________________________________________________________________________|____________| Lung | + + + + + + + + + + | 10 | _____________________________________________________________________________________________________________________| | SPECIAL SENSES SYSTEM | | | None | | | _____________________________________________________________________________________________________________________| | URINARY SYSTEM | | | |__________________________________________________________________________|____________| Kidney | + + + + + + + + + + | 10 | _____________________________________________________________________________________________________________________|____________| * : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade + : Tissue examined microscopically M : Missing tissue 1-4 : Lesion qualified as: X : Lesion present but not qualified A : Autolysis precludes examination 1) Minimal 3) Moderate I : Insufficient tissue BLANK : Not examined 2) Mild 4) Marked Page 24 NTP Experiment-Test: 97013-91 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09 Study Type: 26-39 WEEKS WATER DISINFECTION MODEL (DICHLOROACETIC ACID) Date: 12/05/03 Route: DOSED WATER Time: 09:40:06 __________________________________________________________________________________________________________________________________ | 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| | | DAY ON TEST | 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| | | | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| | | __________________________________________|__________________________________________________________________________| T (*) | | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | O | TGAC (FVB/N) HEMIZYGOUS MALE | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| | T | ANIMAL ID | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | A | 1000MG/L | 2| 2| 2| 2| 2| 2| 2| 2| 2| 3| | L | | 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| | | _____________________________________________________________________________________________________________________|____________| URINARY SYSTEM - cont | | | Nephropathy | 1 1 1 1 1 1 1 | 7 1.0| Renal Tubule, Cyst | X | 1 | Renal Tubule, Dilatation | 2 1 1 2 1 2 | 6 1.5| __________________________________________________________________________________________________________________________________ * : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade + : Tissue examined microscopically M : Missing tissue 1-4 : Lesion qualified as: X : Lesion present but not qualified A : Autolysis precludes examination 1) Minimal 3) Moderate I : Insufficient tissue BLANK : Not examined 2) Mild 4) Marked Page 25 NTP Experiment-Test: 97013-91 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09 Study Type: 26-39 WEEKS WATER DISINFECTION MODEL (DICHLOROACETIC ACID) Date: 12/05/03 Route: DOSED WATER Time: 09:40:06 __________________________________________________________________________________________________________________________________ | 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| | | DAY ON TEST | 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| | | | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| | | __________________________________________|__________________________________________________________________________| T (*) | | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | O | TGAC (FVB/N) HEMIZYGOUS MALE | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| | T | ANIMAL ID | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | A | 2000MG/L | 3| 3| 3| 3| 3| 3| 3| 3| 3| 4| | L | | 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| | | _____________________________________________________________________________________________________________________|____________| ALIMENTARY SYSTEM | | | |__________________________________________________________________________|____________| Intestine Large, Colon | + + + + + + + + + + | 10 | |__________________________________________________________________________|____________| Intestine Large, Rectum | + | 1 | |__________________________________________________________________________|____________| Intestine Large, Cecum | + + + + + + + + + + | 10 | |__________________________________________________________________________|____________| Intestine Small, Duodenum | + + + + + + + + + + | 10 | |__________________________________________________________________________|____________| Intestine Small, Jejunum | + + + + + + + + + + | 10 | |__________________________________________________________________________|____________| Intestine Small, Ileum | + + + + + + + + + + | 10 | |__________________________________________________________________________|____________| Liver | + + + + + + + + + + | 10 | Inflammation, Acute | 2 | 1 2.0| Inflammation, Chronic Active | 1 1 1 1 1 1 1 | 7 1.0| Hepatocyte, Necrosis | 1 2 1 | 3 1.3| Hepatocyte, Vacuolization Cytoplasmic| 4 3 4 4 4 4 4 4 3 4 | 10 3.8| |__________________________________________________________________________|____________| Mesentery | + | 1 | Fat, Fibrosis | 2 | 1 2.0| Fat, Inflammation, Chronic Active | 2 | 1 2.0| Fat, Necrosis | 4 | 1 4.0| Fat, Pigmentation | 2 | 1 2.0| |__________________________________________________________________________|____________| Stomach, Forestomach | + + + + + + + + + + | 10 | Epithelium, Hyperplasia | 2 | 1 2.0| |__________________________________________________________________________|____________| Tooth | + + | 2 | _____________________________________________________________________________________________________________________| | CARDIOVASCULAR SYSTEM | | | None | | | _____________________________________________________________________________________________________________________| | ENDOCRINE SYSTEM | | | _____________________________________________________________________________________________________________________|____________| * : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade + : Tissue examined microscopically M : Missing tissue 1-4 : Lesion qualified as: X : Lesion present but not qualified A : Autolysis precludes examination 1) Minimal 3) Moderate I : Insufficient tissue BLANK : Not examined 2) Mild 4) Marked Page 26 NTP Experiment-Test: 97013-91 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09 Study Type: 26-39 WEEKS WATER DISINFECTION MODEL (DICHLOROACETIC ACID) Date: 12/05/03 Route: DOSED WATER Time: 09:40:06 __________________________________________________________________________________________________________________________________ | 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| | | DAY ON TEST | 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| | | | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| | | __________________________________________|__________________________________________________________________________| T (*) | | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | O | TGAC (FVB/N) HEMIZYGOUS MALE | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| | T | ANIMAL ID | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | A | 2000MG/L | 3| 3| 3| 3| 3| 3| 3| 3| 3| 4| | L | | 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| | | _____________________________________________________________________________________________________________________|____________| ENDOCRINE SYSTEM - cont | | | |__________________________________________________________________________|____________| Adrenal Cortex | + + + + + + + + + + | 10 | Accessory Adrenal Cortical Nodule | 1 | 1 1.0| Hypertrophy | 2 2 2 1 2 2 1 | 7 1.7| |__________________________________________________________________________|____________| Adrenal Medulla | + + + + + + + + + + | 10 | |__________________________________________________________________________|____________| Pituitary Gland | + + + + + + + + + + | 10 | Pars Distalis, Cyst | 1 | 1 1.0| |__________________________________________________________________________|____________| Thyroid Gland | + + + + + + + + + + | 10 | Follicle, Degeneration | 1 1 1 1 | 4 1.0| _____________________________________________________________________________________________________________________| | GENERAL BODY SYSTEM | | | None | | | _____________________________________________________________________________________________________________________| | GENITAL SYSTEM | | | |__________________________________________________________________________|____________| Epididymis | + + + + + + + + + + | 10 | Cyst | 2 | 1 2.0| Degeneration | 4 4 4 | 3 4.0| |__________________________________________________________________________|____________| Testes | + + + + + + + + + + | 10 | Mineralization | 1 | 1 1.0| Germinal Epithelium, Degeneration | 3 4 4 | 3 3.7| Interstitial Cell, Hyperplasia | 2 | 1 2.0| _____________________________________________________________________________________________________________________| | HEMATOPOIETIC SYSTEM | | | |__________________________________________________________________________|____________| Lymph Node, Mandibular | + + + + + + + + + + | 10 | |__________________________________________________________________________|____________| Lymph Node, Mesenteric | + + + + + + + + + + | 10 | |__________________________________________________________________________|____________| Spleen | + + + + + + + + + + | 10 | _____________________________________________________________________________________________________________________|____________| * : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade + : Tissue examined microscopically M : Missing tissue 1-4 : Lesion qualified as: X : Lesion present but not qualified A : Autolysis precludes examination 1) Minimal 3) Moderate I : Insufficient tissue BLANK : Not examined 2) Mild 4) Marked Page 27 NTP Experiment-Test: 97013-91 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09 Study Type: 26-39 WEEKS WATER DISINFECTION MODEL (DICHLOROACETIC ACID) Date: 12/05/03 Route: DOSED WATER Time: 09:40:06 __________________________________________________________________________________________________________________________________ | 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| | | DAY ON TEST | 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| | | | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| | | __________________________________________|__________________________________________________________________________| T (*) | | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | O | TGAC (FVB/N) HEMIZYGOUS MALE | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| | T | ANIMAL ID | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | A | 2000MG/L | 3| 3| 3| 3| 3| 3| 3| 3| 3| 4| | L | | 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| | | _____________________________________________________________________________________________________________________|____________| HEMATOPOIETIC SYSTEM - cont | | | |__________________________________________________________________________|____________| Thymus | + + + + + + + + + + | 10 | Cyst | 1 1 1 | 3 1.0| _____________________________________________________________________________________________________________________| | INTEGUMENTARY SYSTEM | | | |__________________________________________________________________________|____________| Skin | + + + + + + + + | 8 | Inflammation, Chronic Active | 2 | 1 2.0| Epidermis, Hyperplasia | 3 | 1 3.0| _____________________________________________________________________________________________________________________| | MUSCULOSKELETAL SYSTEM | | | None | | | _____________________________________________________________________________________________________________________| | NERVOUS SYSTEM | | | None | | | _____________________________________________________________________________________________________________________| | RESPIRATORY SYSTEM | | | |__________________________________________________________________________|____________| Lung | + + + + + + + + + + | 10 | _____________________________________________________________________________________________________________________| | SPECIAL SENSES SYSTEM | | | None | | | _____________________________________________________________________________________________________________________| | URINARY SYSTEM | | | |__________________________________________________________________________|____________| Kidney | + + + + + + + + + + | 10 | Nephropathy | 1 1 1 1 1 1 1 1 1 1 | 10 1.0| Renal Tubule, Dilatation | 2 1 2 1 1 | 5 1.4| __________________________________________________________________________________________________________________________________ * : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade + : Tissue examined microscopically M : Missing tissue 1-4 : Lesion qualified as: X : Lesion present but not qualified A : Autolysis precludes examination 1) Minimal 3) Moderate I : Insufficient tissue BLANK : Not examined 2) Mild 4) Marked Page 28 ------------------------------------------------------------ ---------- END OF REPORT ---------- ------------------------------------------------------------