TDMS Study 97013-91 Pathology Tables
NTP Experiment-Test: 97013-91 INCIDENCE RATES OF NONNEOPLASTIC LESIONS BY ANATOMIC SITE (a) Report: PEIRPT18
Study Type: 26-39 WEEKS WITH AVERAGE SEVERITY GRADES[b] Date: 12/05/03
Route: DOSED WATER WATER DISINFECTION MODEL (DICHLOROACETIC ACID) Time: 09:42:19
FINAL#1 MICE
Facility: Battelle Columbus Laboratory
Chemical CAS #: 79-43-6
Lock Date: 07/31/01
Cage Range: All
Reasons For Removal: All
Removal Date Range: All
Treatment Groups: Include All
a Number of animals examined microscopically at site and number of animals with lesion
b Average severity grade (1-minimal;2-mild;3-moderate;4-marked)
Page 1
NTP Experiment-Test: 97013-91 INCIDENCE RATES OF NONNEOPLASTIC LESIONS BY ANATOMIC SITE (a) Report: PEIRPT18
Study Type: 26-39 WEEKS WITH AVERAGE SEVERITY GRADES[b] Date: 12/05/03
Route: DOSED WATER WATER DISINFECTION MODEL (DICHLOROACETIC ACID) Time: 09:42:19
____________________________________________________________________________________________________________________________________
TGAC (FVB/N) HEMIZYGOUS FEMALE 0 MG/L 500 MG/L 1000MG/L 2000MG/L
____________________________________________________________________________________________________________________________________
DISPOSITION SUMMARY
Animals Initially In Study 10 10 10 10
Early Deaths
Moribund Sacrifice 1 1 2
Natural Death 2 1 2
Survivors
Terminal Sacrifice 7 9 7 8
Animals Examined Microscopically 10 10 10 10
____________________________________________________________________________________________________________________________________
ALIMENTARY SYSTEM
Liver (10) (10) (10) (10)
Inflammation, Chronic Active 7 [1.1] 10 [1.0] 9 [1.0] 8 [1.0]
Hepatocyte, Fatty Change 1 [1.0]
Hepatocyte, Necrosis 1 [2.0] 1 [1.0] 1 [1.0] 4 [1.0]
Hepatocyte, Vacuolization Cytoplasmic 7 [2.0] 9 [2.6] 9 [2.9] 10 [3.0]
Stomach, Forestomach (10) (10) (10) (10)
Epithelium, Hyperkeratosis 1 [2.0]
Epithelium, Hyperplasia 1 [2.0]
____________________________________________________________________________________________________________________________________
CARDIOVASCULAR SYSTEM
None
____________________________________________________________________________________________________________________________________
ENDOCRINE SYSTEM
Adrenal Cortex (10) (10) (10) (10)
Accessory Adrenal Cortical Nodule 2 [1.0] 2 [1.5] 2 [1.5] 3 [1.3]
Subcapsular, Hyperplasia 3 [1.0] 5 [1.0] 4 [1.0] 8 [1.0]
Adrenal Medulla (10) (10) (10) (10)
Mineralization 1 [1.0]
Pituitary Gland (10) (10) (10) (10)
Pars Distalis, Cyst 2 [1.5] 2 [1.5] 2 [1.0] 2 [1.0]
Thyroid Gland (10) (10) (10) (10)
Ectopic Thymus 1 [2.0]
Follicle, Degeneration 3 [1.0] 6 [1.0] 5 [1.0] 5 [1.0]
____________________________________________________________________________________________________________________________________
GENERAL BODY SYSTEM
a Number of animals examined microscopically at site and number of animals with lesion
b Average severity grade (1-minimal;2-mild;3-moderate;4-marked)
Page 2
NTP Experiment-Test: 97013-91 INCIDENCE RATES OF NONNEOPLASTIC LESIONS BY ANATOMIC SITE (a) Report: PEIRPT18
Study Type: 26-39 WEEKS WITH AVERAGE SEVERITY GRADES[b] Date: 12/05/03
Route: DOSED WATER WATER DISINFECTION MODEL (DICHLOROACETIC ACID) Time: 09:42:19
____________________________________________________________________________________________________________________________________
TGAC (FVB/N) HEMIZYGOUS FEMALE 0 MG/L 500 MG/L 1000MG/L 2000MG/L
____________________________________________________________________________________________________________________________________
None
____________________________________________________________________________________________________________________________________
GENITAL SYSTEM
Ovary (10) (10) (10) (10)
Cyst 7 [2.0] 4 [2.0] 1 [2.0]
Inflammation, Chronic Active 1 [3.0]
Uterus (10) (10) (10) (10)
Endometrium, Hyperplasia, Cystic 7 [2.3] 9 [2.0] 7 [2.1] 7 [1.7]
____________________________________________________________________________________________________________________________________
HEMATOPOIETIC SYSTEM
Lymph Node, Mandibular (10) (10) (10) (10)
Hyperplasia, Lymphoid 1 [3.0] 1 [2.0] 1 [2.0]
Spleen (10) (10) (10) (10)
Atrophy 1 [3.0]
Hematopoietic Cell Proliferation 1 [2.0] 1 [2.0]
Thymus (10) (10) (9) (10)
Atrophy 3 [3.7] 1 [3.0] 1 [4.0] 1 [3.0]
Cyst 3 [1.0] 4 [1.5] 2 [2.0] 5 [1.4]
Ectopic Parathyroid Gland 1 [1.0]
Thrombosis 1 [2.0]
Thymocyte, Necrosis 1 [1.0]
____________________________________________________________________________________________________________________________________
INTEGUMENTARY SYSTEM
Skin (6) (7) (7) (7)
Hyperkeratosis 1 [2.0]
Inflammation, Chronic Active 1 [2.0]
Epidermis, Hyperplasia 1 [3.0] 2 [2.0]
____________________________________________________________________________________________________________________________________
MUSCULOSKELETAL SYSTEM
None
____________________________________________________________________________________________________________________________________
NERVOUS SYSTEM
None
a Number of animals examined microscopically at site and number of animals with lesion
b Average severity grade (1-minimal;2-mild;3-moderate;4-marked)
Page 3
NTP Experiment-Test: 97013-91 INCIDENCE RATES OF NONNEOPLASTIC LESIONS BY ANATOMIC SITE (a) Report: PEIRPT18
Study Type: 26-39 WEEKS WITH AVERAGE SEVERITY GRADES[b] Date: 12/05/03
Route: DOSED WATER WATER DISINFECTION MODEL (DICHLOROACETIC ACID) Time: 09:42:19
____________________________________________________________________________________________________________________________________
TGAC (FVB/N) HEMIZYGOUS FEMALE 0 MG/L 500 MG/L 1000MG/L 2000MG/L
____________________________________________________________________________________________________________________________________
RESPIRATORY SYSTEM
None
____________________________________________________________________________________________________________________________________
SPECIAL SENSES SYSTEM
None
____________________________________________________________________________________________________________________________________
URINARY SYSTEM
Kidney (10) (10) (10) (10)
Infarct 1 [3.0]
Mineralization 1 [1.0]
Nephropathy 3 [1.0] 5 [1.0] 2 [1.0] 7 [1.0]
Glomerulus, Inflammation,
Membranoproliferative 3 [2.7] 1 [3.0] 1 [2.0]
Renal Tubule, Dilatation 3 [1.0] 1 [1.0] 2 [1.0]
a Number of animals examined microscopically at site and number of animals with lesion
b Average severity grade (1-minimal;2-mild;3-moderate;4-marked)
Page 4
NTP Experiment-Test: 97013-91 INCIDENCE RATES OF NONNEOPLASTIC LESIONS BY ANATOMIC SITE (a) Report: PEIRPT18
Study Type: 26-39 WEEKS WITH AVERAGE SEVERITY GRADES[b] Date: 12/05/03
Route: DOSED WATER WATER DISINFECTION MODEL (DICHLOROACETIC ACID) Time: 09:42:19
____________________________________________________________________________________________________________________________________
TGAC (FVB/N) HEMIZYGOUS MALE 0 MG/L 500 MG/L 1000MG/L 2000MG/L
____________________________________________________________________________________________________________________________________
DISPOSITION SUMMARY
Animals Initially In Study 10 10 10 10
Early Deaths
Natural Death 1
Moribund Sacrifice 1
Survivors
Terminal Sacrifice 9 9 10 10
Animals Examined Microscopically 10 10 10 10
____________________________________________________________________________________________________________________________________
ALIMENTARY SYSTEM
Liver (10) (10) (10) (10)
Hematopoietic Cell Proliferation 1 [2.0]
Inflammation, Acute 1 [2.0] 1 [2.0] 1 [2.0]
Inflammation, Chronic Active 9 [1.3] 7 [1.0] 5 [1.0] 7 [1.0]
Hepatocyte, Necrosis 1 [3.0] 1 [1.0] 1 [1.0] 3 [1.3]
Hepatocyte, Vacuolization Cytoplasmic 9 [2.0] 10 [2.3] 9 [3.2] 10 [3.8]
Mesentery (1) (3) (1)
Fat, Fibrosis 2 [2.0] 1 [2.0]
Fat, Inflammation, Chronic Active 1 [2.0] 1 [2.0]
Fat, Necrosis 1 [4.0] 3 [3.7] 1 [4.0]
Fat, Pigmentation 1 [2.0]
Stomach, Forestomach (10) (10) (10) (10)
Epithelium, Hyperplasia 3 [1.7] 1 [2.0]
____________________________________________________________________________________________________________________________________
CARDIOVASCULAR SYSTEM
None
____________________________________________________________________________________________________________________________________
ENDOCRINE SYSTEM
Adrenal Cortex (10) (10) (10) (10)
Accessory Adrenal Cortical Nodule 1 [1.0] 1 [2.0] 1 [1.0]
Atypia Cellular 1 [1.0]
Hematopoietic Cell Proliferation 1 [2.0] 1 [1.0]
Hypertrophy 8 [2.1] 6 [1.5] 9 [2.3] 7 [1.7]
Subcapsular, Hyperplasia 2 [1.5] 1 [1.0] 1 [1.0]
Pituitary Gland (10) (10) (10) (10)
Pars Distalis, Cyst 2 [1.0] 1 [1.0] 1 [1.0]
a Number of animals examined microscopically at site and number of animals with lesion
b Average severity grade (1-minimal;2-mild;3-moderate;4-marked)
Page 5
NTP Experiment-Test: 97013-91 INCIDENCE RATES OF NONNEOPLASTIC LESIONS BY ANATOMIC SITE (a) Report: PEIRPT18
Study Type: 26-39 WEEKS WITH AVERAGE SEVERITY GRADES[b] Date: 12/05/03
Route: DOSED WATER WATER DISINFECTION MODEL (DICHLOROACETIC ACID) Time: 09:42:19
____________________________________________________________________________________________________________________________________
TGAC (FVB/N) HEMIZYGOUS MALE 0 MG/L 500 MG/L 1000MG/L 2000MG/L
____________________________________________________________________________________________________________________________________
ENDOCRINE SYSTEM - CONT
Thyroid Gland (10) (10) (10) (10)
Ectopic Thymus 1 [1.0]
Infiltration Cellular, Lymphocyte 1 [1.0] 1 [1.0]
Follicle, Degeneration 3 [1.0] 9 [1.1] 5 [1.2] 4 [1.0]
____________________________________________________________________________________________________________________________________
GENERAL BODY SYSTEM
None
____________________________________________________________________________________________________________________________________
GENITAL SYSTEM
Epididymis (10) (10) (10) (10)
Cyst 1 [2.0]
Degeneration 1 [4.0] 1 [4.0] 3 [4.0]
Inflammation, Chronic Active 1 [2.0]
Preputial Gland (2) (4) (2)
Inflammation, Chronic Active 1 [4.0]
Duct, Ectasia 2 [2.5] 4 [2.3] 2 [2.0]
Seminal Vesicle (1) (1)
Inflammation, Chronic Active 1 [4.0]
Inflammation, Suppurative 1 [4.0]
Testes (10) (10) (10) (10)
Cyst 1 [2.0]
Mineralization 1 [1.0]
Germinal Epithelium, Degeneration 1 [3.0] 1 [3.0] 3 [3.7]
Interstitial Cell, Hyperplasia 1 [2.0] 1 [2.0]
____________________________________________________________________________________________________________________________________
HEMATOPOIETIC SYSTEM
Lymph Node (1) (2)
Lumbar, Hematopoietic Cell Proliferation 1 [1.0]
Lumbar, Hyperplasia, Lymphoid 1 [2.0]
Mediastinal, Hematopoietic Cell Proliferation 1 [1.0]
Mediastinal, Hyperplasia, Lymphoid 1 [2.0]
Mediastinal, Infiltration Cellular, Mast Cell 1 [3.0]
Mediastinal, Infiltration Cellular,
Histiocyte 1 [2.0]
Renal, Hematopoietic Cell Proliferation 1 [1.0]
Renal, Hyperplasia, Lymphoid 1 [2.0]
Lymph Node, Mandibular (10) (10) (10) (10)
a Number of animals examined microscopically at site and number of animals with lesion
b Average severity grade (1-minimal;2-mild;3-moderate;4-marked)
Page 6
NTP Experiment-Test: 97013-91 INCIDENCE RATES OF NONNEOPLASTIC LESIONS BY ANATOMIC SITE (a) Report: PEIRPT18
Study Type: 26-39 WEEKS WITH AVERAGE SEVERITY GRADES[b] Date: 12/05/03
Route: DOSED WATER WATER DISINFECTION MODEL (DICHLOROACETIC ACID) Time: 09:42:19
____________________________________________________________________________________________________________________________________
TGAC (FVB/N) HEMIZYGOUS MALE 0 MG/L 500 MG/L 1000MG/L 2000MG/L
____________________________________________________________________________________________________________________________________
HEMATOPOIETIC SYSTEM - CONT
Hyperplasia, Lymphoid 1 [2.0] 1 [2.0]
Spleen (10) (10) (10) (10)
Hematopoietic Cell Proliferation 1 [3.0] 1 [3.0]
Necrosis 1 [3.0]
Thymus (10) (10) (9) (10)
Atrophy 2 [3.5] 1 [2.0] 1 [1.0]
Cyst 2 [1.5] 3 [1.3] 4 [1.3] 3 [1.0]
Ectopic Parathyroid Gland 2 [1.0]
____________________________________________________________________________________________________________________________________
INTEGUMENTARY SYSTEM
Skin (9) (9) (9) (8)
Inflammation, Chronic Active 1 [2.0] 1 [2.0]
Epidermis, Hyperplasia 5 [3.0] 4 [2.5] 1 [3.0]
____________________________________________________________________________________________________________________________________
MUSCULOSKELETAL SYSTEM
None
____________________________________________________________________________________________________________________________________
NERVOUS SYSTEM
None
____________________________________________________________________________________________________________________________________
RESPIRATORY SYSTEM
Lung (10) (10) (10) (10)
Hemorrhage 1 [2.0]
Infiltration Cellular, Polymorphonuclear 1 [4.0]
Inflammation, Chronic Active 2 [1.5] 1 [2.0]
Alveolar Epithelium, Hyperplasia 1 [3.0]
____________________________________________________________________________________________________________________________________
SPECIAL SENSES SYSTEM
None
____________________________________________________________________________________________________________________________________
URINARY SYSTEM
a Number of animals examined microscopically at site and number of animals with lesion
b Average severity grade (1-minimal;2-mild;3-moderate;4-marked)
Page 7
NTP Experiment-Test: 97013-91 INCIDENCE RATES OF NONNEOPLASTIC LESIONS BY ANATOMIC SITE (a) Report: PEIRPT18
Study Type: 26-39 WEEKS WITH AVERAGE SEVERITY GRADES[b] Date: 12/05/03
Route: DOSED WATER WATER DISINFECTION MODEL (DICHLOROACETIC ACID) Time: 09:42:19
____________________________________________________________________________________________________________________________________
TGAC (FVB/N) HEMIZYGOUS MALE 0 MG/L 500 MG/L 1000MG/L 2000MG/L
____________________________________________________________________________________________________________________________________
URINARY SYSTEM - CONT
Kidney (10) (10) (10) (10)
Infarct 1 [4.0]
Inflammation, Chronic Active 1 [4.0]
Mineralization 1 [1.0]
Necrosis 1 [3.0]
Nephropathy 9 [1.0] 8 [1.3] 7 [1.0] 10 [1.0]
Pelvis, Inflammation, Chronic 1 [2.0]
Renal Tubule, Cyst 1
Renal Tubule, Dilatation 4 [1.3] 6 [1.7] 6 [1.5] 5 [1.4]
Renal Tubule, Nephropathy 1 [1.0]
a Number of animals examined microscopically at site and number of animals with lesion
b Average severity grade (1-minimal;2-mild;3-moderate;4-marked)
Page 8
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