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TDMS Study 97013-92 Pathology Tables

NTP  EXP/TEST: 97013-92                    WATER DISINFECTION MODEL (SODIUM BROMATE)                              PAGE: 1
TEST TYPE: 26-39 WEEKS           DERMAL CLINICAL OBSERVATIONS AT SITE OF APPLICATION BY ANIMAL                    DATE: 12/08/03
ROUTE: SKIN APPLICATION                                                                                           TIME: 14:18:35

                                                         EIS REPORT 37


       FACILITY:  Battelle Columbus Laboratory

       NTP C#:  97013B

       CONTRACT NUMBER:  N01-ES-65406

       CAS NUMBER:  7789-38-0

       ANIMAL SUPPLIER:  TACONIC FARMS

       CAGE RANGE:  ALL

       DATE RANGE: ALL

       REASONS FOR REMOVAL:    ALL

       REMOVAL DATE RANGE:     ALL

       TREATMENT GROUPS:       INCLUDE ALL

NTP  EXP/TEST: 97013-92                    WATER DISINFECTION MODEL (SODIUM BROMATE)                              PAGE: 2
TEST TYPE: 26-39 WEEKS           DERMAL CLINICAL OBSERVATIONS AT SITE OF APPLICATION BY ANIMAL                    DATE: 12/08/03
ROUTE: SKIN APPLICATION                                     EISRPT37                                              TIME: 14:18:35
------------------------------------------------------------------------------------------------------------------------------------
 SPECIES-STRAIN: MICE-TG.AC HEMI                     TRT#: 2                      ROOM/AREA:    218         FIRST DOSE: 10/29/99
            SEX: FEMALE                               TRT: 0 MG/KG            PROCEDURE SET:      2
------------------------------------------------------------------------------------------------------------------------------------
                FIRST OCCUR'D  LAST  OCCUR'D  FREQ/
CAGE     ANIMAL  DAY    DATE    DAY    DATE  TOT OBS      CLINICAL OBSERVATION
----     ------ -------------  ------------- ------- ------------------------------





                              THERE WERE NO DERMAL OBSERVATIONS FOR THIS SPECIES, STRAIN, SEX, AND TREATMENT GROUP.

NTP  EXP/TEST: 97013-92                    WATER DISINFECTION MODEL (SODIUM BROMATE)                              PAGE: 3
TEST TYPE: 26-39 WEEKS           DERMAL CLINICAL OBSERVATIONS AT SITE OF APPLICATION BY ANIMAL                    DATE: 12/08/03
ROUTE: SKIN APPLICATION                                     EISRPT37                                              TIME: 14:18:35
------------------------------------------------------------------------------------------------------------------------------------
 SPECIES-STRAIN: MICE-TG.AC HEMI                     TRT#: 4                      ROOM/AREA:    218         FIRST DOSE: 10/29/99
            SEX: FEMALE                               TRT: 64 MG/KG           PROCEDURE SET:      2
------------------------------------------------------------------------------------------------------------------------------------
                FIRST OCCUR'D  LAST  OCCUR'D  FREQ/
CAGE     ANIMAL  DAY    DATE    DAY    DATE  TOT OBS      CLINICAL OBSERVATION
----     ------ -------------  ------------- ------- ------------------------------





                              THERE WERE NO DERMAL OBSERVATIONS FOR THIS SPECIES, STRAIN, SEX, AND TREATMENT GROUP.

NTP  EXP/TEST: 97013-92                    WATER DISINFECTION MODEL (SODIUM BROMATE)                              PAGE: 4
TEST TYPE: 26-39 WEEKS           DERMAL CLINICAL OBSERVATIONS AT SITE OF APPLICATION BY ANIMAL                    DATE: 12/08/03
ROUTE: SKIN APPLICATION                                     EISRPT37                                              TIME: 14:18:35
------------------------------------------------------------------------------------------------------------------------------------
 SPECIES-STRAIN: MICE-TG.AC HEMI                     TRT#: 6                      ROOM/AREA:    218         FIRST DOSE: 10/29/99
            SEX: FEMALE                               TRT: 128     MG/KG      PROCEDURE SET:      2
------------------------------------------------------------------------------------------------------------------------------------
                FIRST OCCUR'D  LAST  OCCUR'D  FREQ/
CAGE     ANIMAL  DAY    DATE    DAY    DATE  TOT OBS      CLINICAL OBSERVATION
----     ------ -------------  ------------- ------- ------------------------------

1263       1263  155 03/31/00   176 04/21/00   4/39  Papilloma Site Of Application Small 1

  REMOVED  **  CID  1263 **   REASON - TSAC
                                272 07/26/00         Mass Appendage Small 1
                                272 07/26/00         Papilloma Torso/Ventral Small 3

NTP  EXP/TEST: 97013-92                    WATER DISINFECTION MODEL (SODIUM BROMATE)                              PAGE: 5
TEST TYPE: 26-39 WEEKS           DERMAL CLINICAL OBSERVATIONS AT SITE OF APPLICATION BY ANIMAL                    DATE: 12/08/03
ROUTE: SKIN APPLICATION                                     EISRPT37                                              TIME: 14:18:35
------------------------------------------------------------------------------------------------------------------------------------
 SPECIES-STRAIN: MICE-TG.AC HEMI                     TRT#: 8                      ROOM/AREA:    218         FIRST DOSE: 10/29/99
            SEX: FEMALE                               TRT: 256     MG/KG      PROCEDURE SET:      2
------------------------------------------------------------------------------------------------------------------------------------
                FIRST OCCUR'D  LAST  OCCUR'D  FREQ/
CAGE     ANIMAL  DAY    DATE    DAY    DATE  TOT OBS      CLINICAL OBSERVATION
----     ------ -------------  ------------- ------- ------------------------------

1276       1276  246 06/30/00   253 07/07/00   2/39  Papilloma Site Of Application Small 1

  REMOVED  **  CID  1276 **   REASON - TSAC
                                272 07/26/00         Papilloma Torso/Ventral Small 2


1280       1280  253 07/07/00   267 07/21/00   3/39  Papilloma Site Of Application Small 1

  REMOVED  **  CID  1280 **   REASON - TSAC
                                272 07/26/00         Papilloma Site Of Application Small 1

NTP  EXP/TEST: 97013-92                    WATER DISINFECTION MODEL (SODIUM BROMATE)                              PAGE: 6
TEST TYPE: 26-39 WEEKS           DERMAL CLINICAL OBSERVATIONS AT SITE OF APPLICATION BY ANIMAL                    DATE: 12/08/03
ROUTE: SKIN APPLICATION                                     EISRPT37                                              TIME: 14:18:35
------------------------------------------------------------------------------------------------------------------------------------
 SPECIES-STRAIN: MICE-TG.AC HEMI                     TRT#: 1                      ROOM/AREA:    218         FIRST DOSE: 10/29/99
            SEX: MALE                                 TRT: 0 MG/KG            PROCEDURE SET:      1
------------------------------------------------------------------------------------------------------------------------------------
                FIRST OCCUR'D  LAST  OCCUR'D  FREQ/
CAGE     ANIMAL  DAY    DATE    DAY    DATE  TOT OBS      CLINICAL OBSERVATION
----     ------ -------------  ------------- ------- ------------------------------

1202       1202  176 04/21/00   267 07/21/00  14/39  Papilloma Site Of Application Small 1

  REMOVED  **  CID  1202 **   REASON - TSAC
                                272 07/26/00         Mass Head Small 1
                                272 07/26/00         Papilloma Site Of Application Small 1

NTP  EXP/TEST: 97013-92                    WATER DISINFECTION MODEL (SODIUM BROMATE)                              PAGE: 7
TEST TYPE: 26-39 WEEKS           DERMAL CLINICAL OBSERVATIONS AT SITE OF APPLICATION BY ANIMAL                    DATE: 12/08/03
ROUTE: SKIN APPLICATION                                     EISRPT37                                              TIME: 14:18:35
------------------------------------------------------------------------------------------------------------------------------------
 SPECIES-STRAIN: MICE-TG.AC HEMI                     TRT#: 3                      ROOM/AREA:    218         FIRST DOSE: 10/29/99
            SEX: MALE                                 TRT: 64 MG/KG           PROCEDURE SET:      1
------------------------------------------------------------------------------------------------------------------------------------
                FIRST OCCUR'D  LAST  OCCUR'D  FREQ/
CAGE     ANIMAL  DAY    DATE    DAY    DATE  TOT OBS      CLINICAL OBSERVATION
----     ------ -------------  ------------- ------- ------------------------------





                              THERE WERE NO DERMAL OBSERVATIONS FOR THIS SPECIES, STRAIN, SEX, AND TREATMENT GROUP.

NTP  EXP/TEST: 97013-92                    WATER DISINFECTION MODEL (SODIUM BROMATE)                              PAGE: 8
TEST TYPE: 26-39 WEEKS           DERMAL CLINICAL OBSERVATIONS AT SITE OF APPLICATION BY ANIMAL                    DATE: 12/08/03
ROUTE: SKIN APPLICATION                                     EISRPT37                                              TIME: 14:18:35
------------------------------------------------------------------------------------------------------------------------------------
 SPECIES-STRAIN: MICE-TG.AC HEMI                     TRT#: 5                      ROOM/AREA:    218         FIRST DOSE: 10/29/99
            SEX: MALE                                 TRT: 128     MG/KG      PROCEDURE SET:      1
------------------------------------------------------------------------------------------------------------------------------------
                FIRST OCCUR'D  LAST  OCCUR'D  FREQ/
CAGE     ANIMAL  DAY    DATE    DAY    DATE  TOT OBS      CLINICAL OBSERVATION
----     ------ -------------  ------------- ------- ------------------------------

1223       1223  162 04/07/00   169 04/14/00   2/39  Papilloma Site Of Application Small 1

  REMOVED  **  CID  1223 **   REASON - TSAC
                                272 07/26/00         Unremarkable


1228       1228  232 06/16/00   267 07/21/00   6/39  Papilloma Site Of Application Small 1

  REMOVED  **  CID  1228 **   REASON - TSAC
                                272 07/26/00         Mass Torso/Ventral Medium 1
                                272 07/26/00         Papilloma Site Of Application Small 1
                                272 07/26/00         Papilloma Head Small 2
                                272 07/26/00         Papilloma Torso/Ventral Small 3

NTP  EXP/TEST: 97013-92                    WATER DISINFECTION MODEL (SODIUM BROMATE)                              PAGE: 9
TEST TYPE: 26-39 WEEKS           DERMAL CLINICAL OBSERVATIONS AT SITE OF APPLICATION BY ANIMAL                    DATE: 12/08/03
ROUTE: SKIN APPLICATION                                     EISRPT37                                              TIME: 14:18:35
------------------------------------------------------------------------------------------------------------------------------------
 SPECIES-STRAIN: MICE-TG.AC HEMI                     TRT#: 7                      ROOM/AREA:    218         FIRST DOSE: 10/29/99
            SEX: MALE                                 TRT: 256     MG/KG      PROCEDURE SET:      1
------------------------------------------------------------------------------------------------------------------------------------
                FIRST OCCUR'D  LAST  OCCUR'D  FREQ/
CAGE     ANIMAL  DAY    DATE    DAY    DATE  TOT OBS      CLINICAL OBSERVATION
----     ------ -------------  ------------- ------- ------------------------------

1233       1233  218 06/02/00   232 06/16/00   3/39  Papilloma Site Of Application Small 1

  REMOVED  **  CID  1233 **   REASON - TSAC
                                272 07/26/00         Unremarkable



                                               -----------------------------------
                                               ---------- END-OF-REPORT ----------
                                               -----------------------------------