https://ntp.niehs.nih.gov/go/11591

TDMS Study 97013-92 Pathology Tables

NTP Experiment-Test: 97013-92                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: 26-39 WEEKS                         WATER DISINFECTION MODEL (SODIUM BROMATE)                         Date: 12/08/03
Route: SKIN APPLICATION                                                                                           Time: 14:31:10
                                                          FINAL#1 MICE
       Facility:  Battelle Columbus Laboratory
       Chemical CAS #:  7789-38-0
       Lock Date:  07/30/01
       Cage Range:  All
       Reasons For Removal:    25019 Moribund Sacrifice                25020 Natural Death
                               25021 Terminal Sacrifice
       Removal Date Range:     All
       Treatment Groups:       Include All
                                                              Page   1
NTP Experiment-Test: 97013-92                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09  
Study Type: 26-39 WEEKS                         WATER DISINFECTION MODEL (SODIUM BROMATE)                         Date: 12/08/03    
Route: SKIN APPLICATION                                                                                           Time: 14:31:10    
 __________________________________________________________________________________________________________________________________ 
                                           | 2| 2| 2| 2| 2| 2| 2| 2| 2|                                               |            |
                             DAY ON TEST   | 7| 7| 7| 7| 7| 1| 5| 7| 7|                                               |            |
                                           | 2| 2| 2| 2| 2| 7| 1| 2| 2|                                               |            |
 __________________________________________|__________________________________________________________________________|      T (*) |
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0|                                               |      O     |
   TGAC (FVB/N) HEMIZYGOUS FEMALE          | 1| 1| 1| 1| 1| 1| 1| 1| 1|                                               |      T     |
                               ANIMAL ID   | 2| 2| 2| 2| 2| 2| 2| 2| 2|                                               |      A     |
    0 MG/KG                                | 4| 4| 4| 4| 4| 4| 4| 4| 5|                                               |      L     |
                                           | 1| 2| 3| 4| 5| 7| 8| 9| 0|                                               |            |
 _____________________________________________________________________________________________________________________|____________|
 ALIMENTARY SYSTEM                         |                                                                          |            |
                                           |__________________________________________________________________________|____________|
   Intestine Large, Colon                  | +  +  +  +  +  +  +  +  +                                                |   9        |
                                           |__________________________________________________________________________|____________|
   Intestine Large, Cecum                  | +  +  +  +  +  +  +  +  +                                                |   9        |
                                           |__________________________________________________________________________|____________|
   Intestine Small, Duodenum               | +  +  +  +  +  +  +  +  +                                                |   9        |
                                           |__________________________________________________________________________|____________|
   Intestine Small, Jejunum                | +  +  +  +  +  +  +  +  +                                                |   9        |
                                           |__________________________________________________________________________|____________|
   Intestine Small, Ileum                  | +  +  +  +  +  +  +  +  +                                                |   9        |
                                           |__________________________________________________________________________|____________|
   Liver                                   | +  +  +  +  +  +  +  +  +                                                |   9        |
      Hematopoietic Cell Proliferation     |    1     1                                                               |      2  1.0|
      Inflammation, Chronic Active         | 1  1  1  1  1  1        1                                                |      7  1.0|
      Necrosis                             | 1           1                                                            |      2  1.0|
      Hepatocyte, Fatty Change             |             1                                                            |      1  1.0|
      Hepatocyte, Vacuolization Cytoplasmic| 1  1  1  1  1        2  1                                                |      7  1.1|
                                           |__________________________________________________________________________|____________|
   Salivary Glands                         |    +                                                                     |   1        |
                                           |__________________________________________________________________________|____________|
   Stomach, Forestomach                    | +  +  +  +  +  +  +  +  +                                                |   9        |
      Epithelium, Hyperkeratosis           |                      1                                                   |      1  1.0|
      Epithelium, Hyperplasia              |                      3                                                   |      1  3.0|
                                           |__________________________________________________________________________|____________|
   Tooth                                   |                +  +                                                      |   2        |
 _____________________________________________________________________________________________________________________|            |
 CARDIOVASCULAR SYSTEM                     |                                                                          |            |
    None                                   |                                                                          |            |
 _____________________________________________________________________________________________________________________|            |
 ENDOCRINE SYSTEM                          |                                                                          |            |
                                           |__________________________________________________________________________|____________|
   Adrenal Cortex                          | +  +  +  +  +  +  +  +  +                                                |   9        |
      Accessory Adrenal Cortical Nodule    |    2           2                                                         |      2  2.0|
      Subcapsular, Hyperplasia             |                1  1  1  1                                                |      4  1.0|
 _____________________________________________________________________________________________________________________|____________|
  * : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade                         
  + : Tissue examined microscopically                M : Missing tissue                        1-4 : Lesion qualified as:           
  X : Lesion present but not qualified               A : Autolysis precludes examination               1) Minimal  3) Moderate      
  I : Insufficient tissue                        BLANK : Not examined                                  2) Mild     4) Marked        
                                                             Page   2                                                               
NTP Experiment-Test: 97013-92                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09  
Study Type: 26-39 WEEKS                         WATER DISINFECTION MODEL (SODIUM BROMATE)                         Date: 12/08/03    
Route: SKIN APPLICATION                                                                                           Time: 14:31:10    
 __________________________________________________________________________________________________________________________________ 
                                           | 2| 2| 2| 2| 2| 2| 2| 2| 2|                                               |            |
                             DAY ON TEST   | 7| 7| 7| 7| 7| 1| 5| 7| 7|                                               |            |
                                           | 2| 2| 2| 2| 2| 7| 1| 2| 2|                                               |            |
 __________________________________________|__________________________________________________________________________|      T (*) |
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0|                                               |      O     |
   TGAC (FVB/N) HEMIZYGOUS FEMALE          | 1| 1| 1| 1| 1| 1| 1| 1| 1|                                               |      T     |
                               ANIMAL ID   | 2| 2| 2| 2| 2| 2| 2| 2| 2|                                               |      A     |
    0 MG/KG                                | 4| 4| 4| 4| 4| 4| 4| 4| 5|                                               |      L     |
                                           | 1| 2| 3| 4| 5| 7| 8| 9| 0|                                               |            |
 _____________________________________________________________________________________________________________________|____________|
 ENDOCRINE SYSTEM - cont                   |                                                                          |            |
                                           |__________________________________________________________________________|____________|
   Adrenal Medulla                         | +  +  +  +  +  +  +  +  +                                                |   9        |
                                           |__________________________________________________________________________|____________|
   Pituitary Gland                         | +  +  +  +  +  +  +  +  +                                                |   9        |
      Pars Distalis, Inflammation, Chronic |                                                                          |            |
          Active                           |    3                                                                     |      1  3.0|
                                           |__________________________________________________________________________|____________|
   Thyroid Gland                           | +  +  +  +  +  +  +  +  +                                                |   9        |
      Follicle, Depletion Secretory        |    1  2  1  1        1                                                   |      5  1.2|
      Follicular Cell, Hypertrophy         |                         1                                                |      1  1.0|
 _____________________________________________________________________________________________________________________|            |
 GENERAL BODY SYSTEM                       |                                                                          |            |
    None                                   |                                                                          |            |
 _____________________________________________________________________________________________________________________|            |
 GENITAL SYSTEM                            |                                                                          |            |
                                           |__________________________________________________________________________|____________|
   Ovary                                   | +  +  +  +  +  +  +  +  +                                                |   9        |
      Cyst                                 |       2                                                                  |      1  2.0|
      Inflammation, Chronic Active         |          3                                                               |      1  3.0|
                                           |__________________________________________________________________________|____________|
   Uterus                                  | +  +  +  +  +  +  +  +  +                                                |   9        |
      Endometrium, Hyperplasia, Cystic     | 2  1  2  4  1  2     1  2                                                |      8  1.9|
 _____________________________________________________________________________________________________________________|            |
 HEMATOPOIETIC SYSTEM                      |                                                                          |            |
                                           |__________________________________________________________________________|____________|
   Lymph Node, Mandibular                  | +  +  +  +  +  +  +  +  +                                                |   9        |
      Hyperplasia, Lymphoid                |                3                                                         |      1  3.0|
                                           |__________________________________________________________________________|____________|
   Lymph Node, Mesenteric                  | +  +  +  +  +  +  +  +  +                                                |   9        |
                                           |__________________________________________________________________________|____________|
   Spleen                                  | +  +  +  +  +  +  +  +  +                                                |   9        |
      Atrophy                              |                   3                                                      |      1  3.0|
      Hematopoietic Cell Proliferation     |    2  2  2                                                               |      3  2.0|
                                           |__________________________________________________________________________|____________|
 _____________________________________________________________________________________________________________________|____________|
  * : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade                         
  + : Tissue examined microscopically                M : Missing tissue                        1-4 : Lesion qualified as:           
  X : Lesion present but not qualified               A : Autolysis precludes examination               1) Minimal  3) Moderate      
  I : Insufficient tissue                        BLANK : Not examined                                  2) Mild     4) Marked        
                                                             Page   3                                                               
NTP Experiment-Test: 97013-92                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09  
Study Type: 26-39 WEEKS                         WATER DISINFECTION MODEL (SODIUM BROMATE)                         Date: 12/08/03    
Route: SKIN APPLICATION                                                                                           Time: 14:31:10    
 __________________________________________________________________________________________________________________________________ 
                                           | 2| 2| 2| 2| 2| 2| 2| 2| 2|                                               |            |
                             DAY ON TEST   | 7| 7| 7| 7| 7| 1| 5| 7| 7|                                               |            |
                                           | 2| 2| 2| 2| 2| 7| 1| 2| 2|                                               |            |
 __________________________________________|__________________________________________________________________________|      T (*) |
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0|                                               |      O     |
   TGAC (FVB/N) HEMIZYGOUS FEMALE          | 1| 1| 1| 1| 1| 1| 1| 1| 1|                                               |      T     |
                               ANIMAL ID   | 2| 2| 2| 2| 2| 2| 2| 2| 2|                                               |      A     |
    0 MG/KG                                | 4| 4| 4| 4| 4| 4| 4| 4| 5|                                               |      L     |
                                           | 1| 2| 3| 4| 5| 7| 8| 9| 0|                                               |            |
 _____________________________________________________________________________________________________________________|____________|
 HEMATOPOIETIC SYSTEM - cont               |                                                                          |            |
   Thymus                                  | +  +  +  +  +  M  +  +  +                                                |   8        |
      Atrophy                              |                   4                                                      |      1  4.0|
 _____________________________________________________________________________________________________________________|            |
 INTEGUMENTARY SYSTEM                      |                                                                          |            |
                                           |__________________________________________________________________________|____________|
   Mammary Gland                           | +  +  +  +  +  +  +  +  +                                                |   9        |
                                           |__________________________________________________________________________|____________|
   Skin                                    | +  +  +  +  +  +  +  +  +                                                |   9        |
      Epidermis, Hyperplasia, Focal        | 2           3                                                            |      2  2.5|
 _____________________________________________________________________________________________________________________|            |
 MUSCULOSKELETAL SYSTEM                    |                                                                          |            |
    None                                   |                                                                          |            |
 _____________________________________________________________________________________________________________________|            |
 NERVOUS SYSTEM                            |                                                                          |            |
    None                                   |                                                                          |            |
 _____________________________________________________________________________________________________________________|            |
 RESPIRATORY SYSTEM                        |                                                                          |            |
                                           |__________________________________________________________________________|____________|
   Lung                                    | +  +  +  +  +  +  +  +  +                                                |   9        |
 _____________________________________________________________________________________________________________________|            |
 SPECIAL SENSES SYSTEM                     |                                                                          |            |
                                           |__________________________________________________________________________|____________|
   Eye                                     |    +                                                                     |   1        |
      Cornea, Inflammation, Chronic Active |    2                                                                     |      1  2.0|
                                           |__________________________________________________________________________|____________|
   Zymbal's Gland                          |    +              +                                                      |   2        |
      Cyst                                 |    4                                                                     |      1  4.0|
      Inflammation, Chronic Active         |    4                                                                     |      1  4.0|
 _____________________________________________________________________________________________________________________|            |
 URINARY SYSTEM                            |                                                                          |            |
                                           |__________________________________________________________________________|____________|
   Kidney                                  | +  +  +  +  +  +  +  +  +                                                |   9        |
      Nephropathy                          | 1  1        1        1  1                                                |      5  1.0|
      Cortex, Cyst                         |             2                                                            |      1  2.0|
 __________________________________________________________________________________________________________________________________ 
  * : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade                         
  + : Tissue examined microscopically                M : Missing tissue                        1-4 : Lesion qualified as:           
  X : Lesion present but not qualified               A : Autolysis precludes examination               1) Minimal  3) Moderate      
  I : Insufficient tissue                        BLANK : Not examined                                  2) Mild     4) Marked        
                                                             Page   4                                                               
NTP Experiment-Test: 97013-92                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09  
Study Type: 26-39 WEEKS                         WATER DISINFECTION MODEL (SODIUM BROMATE)                         Date: 12/08/03    
Route: SKIN APPLICATION                                                                                           Time: 14:31:10    
 __________________________________________________________________________________________________________________________________ 
                                           | 0| 2| 2| 1| 2| 2| 2| 1| 2| 2|                                            |            |
                             DAY ON TEST   | 6| 7| 7| 4| 7| 7| 7| 4| 7| 7|                                            |            |
                                           | 2| 2| 2| 4| 2| 2| 2| 8| 2| 2|                                            |            |
 __________________________________________|__________________________________________________________________________|      T (*) |
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|                                            |      O     |
   TGAC (FVB/N) HEMIZYGOUS FEMALE          | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1|                                            |      T     |
                               ANIMAL ID   | 2| 2| 2| 2| 2| 2| 2| 2| 2| 2|                                            |      A     |
    64 MG/KG                               | 5| 5| 5| 5| 5| 5| 5| 5| 5| 6|                                            |      L     |
                                           | 1| 2| 3| 4| 5| 6| 7| 8| 9| 0|                                            |            |
 _____________________________________________________________________________________________________________________|____________|
 ALIMENTARY SYSTEM                         |                                                                          |            |
                                           |__________________________________________________________________________|____________|
   Gallbladder                             |                      +                                                   |   1        |
                                           |__________________________________________________________________________|____________|
   Intestine Large, Colon                  | +  +  +  +  +  +  +  +  +  +                                             |  10        |
                                           |__________________________________________________________________________|____________|
   Intestine Large, Cecum                  | +  +  +  +  +  +  +  +  +  +                                             |  10        |
                                           |__________________________________________________________________________|____________|
   Intestine Small, Duodenum               | +  +  +  +  +  +  +  +  +  +                                             |  10        |
                                           |__________________________________________________________________________|____________|
   Intestine Small, Jejunum                | +  +  +  +  +  +  +  +  +  +                                             |  10        |
                                           |__________________________________________________________________________|____________|
   Intestine Small, Ileum                  | +  +  +  +  +  +  +  +  +  +                                             |  10        |
                                           |__________________________________________________________________________|____________|
   Liver                                   | +  +  +  +  +  +  +  +  +  +                                             |  10        |
      Hematopoietic Cell Proliferation     |    1           1                                                         |      2  1.0|
      Inflammation, Chronic Active         | 1  1  1     1  1  1  1  1  1                                             |      9  1.0|
      Necrosis                             |                1                                                         |      1  1.0|
      Hepatocyte, Vacuolization Cytoplasmic|             1        1  1  1                                             |      4  1.0|
                                           |__________________________________________________________________________|____________|
   Salivary Glands                         |          +                                                               |   1        |
                                           |__________________________________________________________________________|____________|
   Stomach, Forestomach                    | +  +  +  +  +  +  +  +  +  +                                             |  10        |
      Epithelium, Hyperkeratosis           |    2                                                                     |      1  2.0|
      Epithelium, Hyperplasia              |    3                                                                     |      1  3.0|
                                           |__________________________________________________________________________|____________|
   Tooth                                   |    +  +  +                 +                                             |   4        |
 _____________________________________________________________________________________________________________________|            |
 CARDIOVASCULAR SYSTEM                     |                                                                          |            |
    None                                   |                                                                          |            |
 _____________________________________________________________________________________________________________________|            |
 ENDOCRINE SYSTEM                          |                                                                          |            |
                                           |__________________________________________________________________________|____________|
   Adrenal Cortex                          | +  +  +  +  +  +  +  +  +  +                                             |  10        |
      Accessory Adrenal Cortical Nodule    |                         3  2                                             |      2  2.5|
 _____________________________________________________________________________________________________________________|____________|
  * : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade                         
  + : Tissue examined microscopically                M : Missing tissue                        1-4 : Lesion qualified as:           
  X : Lesion present but not qualified               A : Autolysis precludes examination               1) Minimal  3) Moderate      
  I : Insufficient tissue                        BLANK : Not examined                                  2) Mild     4) Marked        
                                                             Page   5                                                               
NTP Experiment-Test: 97013-92                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09  
Study Type: 26-39 WEEKS                         WATER DISINFECTION MODEL (SODIUM BROMATE)                         Date: 12/08/03    
Route: SKIN APPLICATION                                                                                           Time: 14:31:10    
 __________________________________________________________________________________________________________________________________ 
                                           | 0| 2| 2| 1| 2| 2| 2| 1| 2| 2|                                            |            |
                             DAY ON TEST   | 6| 7| 7| 4| 7| 7| 7| 4| 7| 7|                                            |            |
                                           | 2| 2| 2| 4| 2| 2| 2| 8| 2| 2|                                            |            |
 __________________________________________|__________________________________________________________________________|      T (*) |
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|                                            |      O     |
   TGAC (FVB/N) HEMIZYGOUS FEMALE          | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1|                                            |      T     |
                               ANIMAL ID   | 2| 2| 2| 2| 2| 2| 2| 2| 2| 2|                                            |      A     |
    64 MG/KG                               | 5| 5| 5| 5| 5| 5| 5| 5| 5| 6|                                            |      L     |
                                           | 1| 2| 3| 4| 5| 6| 7| 8| 9| 0|                                            |            |
 _____________________________________________________________________________________________________________________|____________|
 ENDOCRINE SYSTEM - cont                   |                                                                          |            |
      Subcapsular, Hyperplasia             |    1  1     1  1     1  1  1                                             |      7  1.0|
                                           |__________________________________________________________________________|____________|
   Adrenal Medulla                         | +  +  +  +  +  +  +  +  +  +                                             |  10        |
                                           |__________________________________________________________________________|____________|
   Pituitary Gland                         | +  +  +  +  +  +  +  +  +  +                                             |  10        |
                                           |__________________________________________________________________________|____________|
   Thyroid Gland                           | +  +  +  +  +  +  +  +  +  +                                             |  10        |
      Infiltration Cellular, Lymphocyte    |             1     2                                                      |      2  1.5|
      Follicle, Depletion Secretory        |    1  1     2  2  2  1  1  2                                             |      8  1.5|
      Follicular Cell, Hypertrophy         | 1  1  2     2  2  1  1  2  2                                             |      9  1.6|
 _____________________________________________________________________________________________________________________|            |
 GENERAL BODY SYSTEM                       |                                                                          |            |
    None                                   |                                                                          |            |
 _____________________________________________________________________________________________________________________|            |
 GENITAL SYSTEM                            |                                                                          |            |
                                           |__________________________________________________________________________|____________|
   Ovary                                   | +  +  +  +  +  +  +  +  +  +                                             |  10        |
      Cyst                                 |       1     1     1     1                                                |      4  1.0|
                                           |__________________________________________________________________________|____________|
   Uterus                                  | +  +  +  +  +  +  +  +  +  +                                             |  10        |
      Endometrium, Hyperplasia, Cystic     |       2     1  1  3  2  2  3                                             |      7  2.0|
 _____________________________________________________________________________________________________________________|            |
 HEMATOPOIETIC SYSTEM                      |                                                                          |            |
                                           |__________________________________________________________________________|____________|
   Lymph Node, Mandibular                  | +  +  +  +  +  +  +  +  +  +                                             |  10        |
      Hyperplasia, Lymphoid                |    4                    2  2                                             |      3  2.7|
                                           |__________________________________________________________________________|____________|
   Lymph Node, Mesenteric                  | +  +  +  +  +  +  +  +  +  +                                             |  10        |
                                           |__________________________________________________________________________|____________|
   Spleen                                  | +  +  +  +  +  +  +  +  +  +                                             |  10        |
      Atrophy                              |          3                                                               |      1  3.0|
      Hematopoietic Cell Proliferation     |    2  1     2  2  2     2                                                |      6  1.8|
                                           |__________________________________________________________________________|____________|
   Thymus                                  | +  +  +  +  +  +  +  +  +  +                                             |  10        |
 _____________________________________________________________________________________________________________________|____________|
  * : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade                         
  + : Tissue examined microscopically                M : Missing tissue                        1-4 : Lesion qualified as:           
  X : Lesion present but not qualified               A : Autolysis precludes examination               1) Minimal  3) Moderate      
  I : Insufficient tissue                        BLANK : Not examined                                  2) Mild     4) Marked        
                                                             Page   6                                                               
NTP Experiment-Test: 97013-92                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09  
Study Type: 26-39 WEEKS                         WATER DISINFECTION MODEL (SODIUM BROMATE)                         Date: 12/08/03    
Route: SKIN APPLICATION                                                                                           Time: 14:31:10    
 __________________________________________________________________________________________________________________________________ 
                                           | 0| 2| 2| 1| 2| 2| 2| 1| 2| 2|                                            |            |
                             DAY ON TEST   | 6| 7| 7| 4| 7| 7| 7| 4| 7| 7|                                            |            |
                                           | 2| 2| 2| 4| 2| 2| 2| 8| 2| 2|                                            |            |
 __________________________________________|__________________________________________________________________________|      T (*) |
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|                                            |      O     |
   TGAC (FVB/N) HEMIZYGOUS FEMALE          | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1|                                            |      T     |
                               ANIMAL ID   | 2| 2| 2| 2| 2| 2| 2| 2| 2| 2|                                            |      A     |
    64 MG/KG                               | 5| 5| 5| 5| 5| 5| 5| 5| 5| 6|                                            |      L     |
                                           | 1| 2| 3| 4| 5| 6| 7| 8| 9| 0|                                            |            |
 _____________________________________________________________________________________________________________________|____________|
 HEMATOPOIETIC SYSTEM - cont               |                                                                          |            |
      Atrophy                              |          4                                                               |      1  4.0|
      Cyst                                 |                1                                                         |      1  1.0|
 _____________________________________________________________________________________________________________________|            |
 INTEGUMENTARY SYSTEM                      |                                                                          |            |
                                           |__________________________________________________________________________|____________|
   Mammary Gland                           | +  +  +  +  +  +  +  +  +  +                                             |  10        |
                                           |__________________________________________________________________________|____________|
   Skin                                    | +  +  +  +  +  +  +  +  +  +                                             |  10        |
      Epidermis, Hyperplasia, Focal        |       2           2                                                      |      2  2.0|
 _____________________________________________________________________________________________________________________|            |
 MUSCULOSKELETAL SYSTEM                    |                                                                          |            |
    None                                   |                                                                          |            |
 _____________________________________________________________________________________________________________________|            |
 NERVOUS SYSTEM                            |                                                                          |            |
    None                                   |                                                                          |            |
 _____________________________________________________________________________________________________________________|            |
 RESPIRATORY SYSTEM                        |                                                                          |            |
                                           |__________________________________________________________________________|____________|
   Lung                                    | +  +  +  +  +  +  +  +  +  +                                             |  10        |
      Inflammation, Chronic Active         |    2                                                                     |      1  2.0|
 _____________________________________________________________________________________________________________________|            |
 SPECIAL SENSES SYSTEM                     |                                                                          |            |
    None                                   |                                                                          |            |
 _____________________________________________________________________________________________________________________|            |
 URINARY SYSTEM                            |                                                                          |            |
                                           |__________________________________________________________________________|____________|
   Kidney                                  | +  +  +  +  +  +  +  +  +  +                                             |  10        |
      Nephropathy                          |    1           1  1  1  1  1                                             |      6  1.0|
      Artery, Inflammation, Chronic Active |                2                                                         |      1  2.0|
 __________________________________________________________________________________________________________________________________ 
  * : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade                         
  + : Tissue examined microscopically                M : Missing tissue                        1-4 : Lesion qualified as:           
  X : Lesion present but not qualified               A : Autolysis precludes examination               1) Minimal  3) Moderate      
  I : Insufficient tissue                        BLANK : Not examined                                  2) Mild     4) Marked        
                                                             Page   7                                                               
NTP Experiment-Test: 97013-92                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09  
Study Type: 26-39 WEEKS                         WATER DISINFECTION MODEL (SODIUM BROMATE)                         Date: 12/08/03    
Route: SKIN APPLICATION                                                                                           Time: 14:31:10    
 __________________________________________________________________________________________________________________________________ 
                                           | 1| 2| 2| 2| 2| 2| 2| 2| 2| 2|                                            |            |
                             DAY ON TEST   | 2| 7| 7| 7| 7| 7| 7| 7| 2| 7|                                            |            |
                                           | 7| 2| 2| 2| 2| 2| 2| 2| 1| 2|                                            |            |
 __________________________________________|__________________________________________________________________________|      T (*) |
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|                                            |      O     |
   TGAC (FVB/N) HEMIZYGOUS FEMALE          | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1|                                            |      T     |
                               ANIMAL ID   | 2| 2| 2| 2| 2| 2| 2| 2| 2| 2|                                            |      A     |
    128                                    | 6| 6| 6| 6| 6| 6| 6| 6| 6| 7|                                            |      L     |
    MG/KG                                  | 1| 2| 3| 4| 5| 6| 7| 8| 9| 0|                                            |            |
 _____________________________________________________________________________________________________________________|____________|
 ALIMENTARY SYSTEM                         |                                                                          |            |
                                           |__________________________________________________________________________|____________|
   Intestine Large, Colon                  | +  +  +  +  +  +  +  +  +  +                                             |  10        |
                                           |__________________________________________________________________________|____________|
   Intestine Large, Cecum                  | +  +  +  +  +  +  +  +  +  +                                             |  10        |
                                           |__________________________________________________________________________|____________|
   Intestine Small, Duodenum               | +  +  +  +  +  +  +  +  +  +                                             |  10        |
                                           |__________________________________________________________________________|____________|
   Intestine Small, Jejunum                | +  +  +  +  +  +  +  +  +  +                                             |  10        |
                                           |__________________________________________________________________________|____________|
   Intestine Small, Ileum                  | +  +  +  +  +  +  +  +  +  +                                             |  10        |
                                           |__________________________________________________________________________|____________|
   Liver                                   | +  +  +  +  +  +  +  +  +  +                                             |  10        |
      Hematopoietic Cell Proliferation     | 1        1                                                               |      2  1.0|
      Inflammation, Chronic Active         | 2  1  1  1  1  1  1  1  2  1                                             |     10  1.2|
      Necrosis                             |                1                                                         |      1  1.0|
      Hepatocyte, Vacuolization Cytoplasmic|    1  1     1  1  1  2  1                                                |      7  1.1|
                                           |__________________________________________________________________________|____________|
   Salivary Glands                         |          +                                                               |   1        |
                                           |__________________________________________________________________________|____________|
   Stomach, Forestomach                    | +  +  +  +  +  +  +  +  +  +                                             |  10        |
      Epithelium, Hyperkeratosis           | 2                 2                                                      |      2  2.0|
      Epithelium, Hyperplasia              | 2              2  3                                                      |      3  2.3|
                                           |__________________________________________________________________________|____________|
   Tooth                                   | +        +                 +                                             |   3        |
 _____________________________________________________________________________________________________________________|            |
 CARDIOVASCULAR SYSTEM                     |                                                                          |            |
    None                                   |                                                                          |            |
 _____________________________________________________________________________________________________________________|            |
 ENDOCRINE SYSTEM                          |                                                                          |            |
                                           |__________________________________________________________________________|____________|
   Adrenal Cortex                          | +  +  +  +  +  +  +  +  +  +                                             |  10        |
      Accessory Adrenal Cortical Nodule    | 1  2                                                                     |      2  1.5|
      Subcapsular, Hyperplasia             |    1     1  1  1  1     1  1                                             |      7  1.0|
                                           |__________________________________________________________________________|____________|
 _____________________________________________________________________________________________________________________|____________|
  * : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade                         
  + : Tissue examined microscopically                M : Missing tissue                        1-4 : Lesion qualified as:           
  X : Lesion present but not qualified               A : Autolysis precludes examination               1) Minimal  3) Moderate      
  I : Insufficient tissue                        BLANK : Not examined                                  2) Mild     4) Marked        
                                                             Page   8                                                               
NTP Experiment-Test: 97013-92                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09  
Study Type: 26-39 WEEKS                         WATER DISINFECTION MODEL (SODIUM BROMATE)                         Date: 12/08/03    
Route: SKIN APPLICATION                                                                                           Time: 14:31:10    
 __________________________________________________________________________________________________________________________________ 
                                           | 1| 2| 2| 2| 2| 2| 2| 2| 2| 2|                                            |            |
                             DAY ON TEST   | 2| 7| 7| 7| 7| 7| 7| 7| 2| 7|                                            |            |
                                           | 7| 2| 2| 2| 2| 2| 2| 2| 1| 2|                                            |            |
 __________________________________________|__________________________________________________________________________|      T (*) |
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|                                            |      O     |
   TGAC (FVB/N) HEMIZYGOUS FEMALE          | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1|                                            |      T     |
                               ANIMAL ID   | 2| 2| 2| 2| 2| 2| 2| 2| 2| 2|                                            |      A     |
    128                                    | 6| 6| 6| 6| 6| 6| 6| 6| 6| 7|                                            |      L     |
    MG/KG                                  | 1| 2| 3| 4| 5| 6| 7| 8| 9| 0|                                            |            |
 _____________________________________________________________________________________________________________________|____________|
 ENDOCRINE SYSTEM - cont                   |                                                                          |            |
   Adrenal Medulla                         | +  +  +  +  +  +  +  +  +  +                                             |  10        |
                                           |__________________________________________________________________________|____________|
   Pituitary Gland                         | +  +  +  +  +  +  +  +  +  +                                             |  10        |
                                           |__________________________________________________________________________|____________|
   Thyroid Gland                           | +  +  +  +  +  +  +  +  +  +                                             |  10        |
      Infiltration Cellular, Lymphocyte    |    1     1  2     1  1                                                   |      5  1.2|
      Follicle, Depletion Secretory        | 2  3  3  3  3  3  3  3  2  2                                             |     10  2.7|
      Follicular Cell, Hypertrophy         |    3  3  3  3  3  3  3  2  3                                             |      9  2.9|
 _____________________________________________________________________________________________________________________|            |
 GENERAL BODY SYSTEM                       |                                                                          |            |
    None                                   |                                                                          |            |
 _____________________________________________________________________________________________________________________|            |
 GENITAL SYSTEM                            |                                                                          |            |
                                           |__________________________________________________________________________|____________|
   Ovary                                   | +  +  +  +  +  +  +  +  +  +                                             |  10        |
      Cyst                                 |             2     2                                                      |      2  2.0|
                                           |__________________________________________________________________________|____________|
   Uterus                                  | +  +  +  +  +  +  +  +  +  +                                             |  10        |
      Endometrium, Hyperplasia, Cystic     |    2  2  1  3  1  1  1     1                                             |      8  1.5|
 _____________________________________________________________________________________________________________________|            |
 HEMATOPOIETIC SYSTEM                      |                                                                          |            |
                                           |__________________________________________________________________________|____________|
   Lymph Node, Mandibular                  | +  +  +  +  +  +  +  +  +  +                                             |  10        |
      Hyperplasia, Lymphoid                | 2                       2                                                |      2  2.0|
                                           |__________________________________________________________________________|____________|
   Lymph Node, Mesenteric                  | +  +  +  +  +  +  +  +  +  +                                             |  10        |
                                           |__________________________________________________________________________|____________|
   Spleen                                  | +  +  +  +  +  +  +  +  +  +                                             |  10        |
      Hematopoietic Cell Proliferation     | 2  2  2  2  2  2  1  1                                                   |      8  1.8|
                                           |__________________________________________________________________________|____________|
   Thymus                                  | +  +  +  +  +  +  +  +  +  +                                             |  10        |
      Atrophy                              | 3                          3                                             |      2  3.0|
      Cyst                                 |          1     1                                                         |      2  1.0|
 _____________________________________________________________________________________________________________________|            |
 _____________________________________________________________________________________________________________________|____________|
  * : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade                         
  + : Tissue examined microscopically                M : Missing tissue                        1-4 : Lesion qualified as:           
  X : Lesion present but not qualified               A : Autolysis precludes examination               1) Minimal  3) Moderate      
  I : Insufficient tissue                        BLANK : Not examined                                  2) Mild     4) Marked        
                                                             Page   9                                                               
NTP Experiment-Test: 97013-92                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09  
Study Type: 26-39 WEEKS                         WATER DISINFECTION MODEL (SODIUM BROMATE)                         Date: 12/08/03    
Route: SKIN APPLICATION                                                                                           Time: 14:31:10    
 __________________________________________________________________________________________________________________________________ 
                                           | 1| 2| 2| 2| 2| 2| 2| 2| 2| 2|                                            |            |
                             DAY ON TEST   | 2| 7| 7| 7| 7| 7| 7| 7| 2| 7|                                            |            |
                                           | 7| 2| 2| 2| 2| 2| 2| 2| 1| 2|                                            |            |
 __________________________________________|__________________________________________________________________________|      T (*) |
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|                                            |      O     |
   TGAC (FVB/N) HEMIZYGOUS FEMALE          | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1|                                            |      T     |
                               ANIMAL ID   | 2| 2| 2| 2| 2| 2| 2| 2| 2| 2|                                            |      A     |
    128                                    | 6| 6| 6| 6| 6| 6| 6| 6| 6| 7|                                            |      L     |
    MG/KG                                  | 1| 2| 3| 4| 5| 6| 7| 8| 9| 0|                                            |            |
 _____________________________________________________________________________________________________________________|____________|
 INTEGUMENTARY SYSTEM                      |                                                                          |            |
                                           |__________________________________________________________________________|____________|
   Mammary Gland                           | +  +  +  +  +  +  +  +  +  +                                             |  10        |
                                           |__________________________________________________________________________|____________|
   Skin                                    | +  +  +  +  +  +  +  +  +  +                                             |  10        |
      Inflammation, Chronic Active         |                         2                                                |      1  2.0|
      Ulcer                                |                         4                                                |      1  4.0|
      Epidermis, Hyperplasia, Focal        |    3  3     4  3  2     4                                                |      6  3.2|
      Site of Application - Epidermis,     |                                                                          |            |
           Hyperplasia                     |                1                                                         |      1  1.0|
 _____________________________________________________________________________________________________________________|            |
 MUSCULOSKELETAL SYSTEM                    |                                                                          |            |
    None                                   |                                                                          |            |
 _____________________________________________________________________________________________________________________|            |
 NERVOUS SYSTEM                            |                                                                          |            |
    None                                   |                                                                          |            |
 _____________________________________________________________________________________________________________________|            |
 RESPIRATORY SYSTEM                        |                                                                          |            |
                                           |__________________________________________________________________________|____________|
   Lung                                    | +  +  +  +  +  +  +  +  +  +                                             |  10        |
      Inflammation, Chronic Active         |                1                                                         |      1  1.0|
 _____________________________________________________________________________________________________________________|            |
 SPECIAL SENSES SYSTEM                     |                                                                          |            |
    None                                   |                                                                          |            |
 _____________________________________________________________________________________________________________________|            |
 URINARY SYSTEM                            |                                                                          |            |
                                           |__________________________________________________________________________|____________|
   Kidney                                  | +  +  +  +  +  +  +  +  +  +                                             |  10        |
      Mineralization                       |                      1                                                   |      1  1.0|
      Nephropathy                          |    1  1  1  1  1  1     1  1                                             |      8  1.0|
 __________________________________________________________________________________________________________________________________ 
  * : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade                         
  + : Tissue examined microscopically                M : Missing tissue                        1-4 : Lesion qualified as:           
  X : Lesion present but not qualified               A : Autolysis precludes examination               1) Minimal  3) Moderate      
  I : Insufficient tissue                        BLANK : Not examined                                  2) Mild     4) Marked        
                                                             Page  10                                                               
NTP Experiment-Test: 97013-92                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09  
Study Type: 26-39 WEEKS                         WATER DISINFECTION MODEL (SODIUM BROMATE)                         Date: 12/08/03    
Route: SKIN APPLICATION                                                                                           Time: 14:31:10    
 __________________________________________________________________________________________________________________________________ 
                                           | 2| 2| 2| 2| 2| 2| 2| 2| 2| 2|                                            |            |
                             DAY ON TEST   | 7| 1| 7| 7| 7| 7| 7| 7| 5| 7|                                            |            |
                                           | 2| 8| 2| 2| 2| 2| 2| 2| 7| 2|                                            |            |
 __________________________________________|__________________________________________________________________________|      T (*) |
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|                                            |      O     |
   TGAC (FVB/N) HEMIZYGOUS FEMALE          | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1|                                            |      T     |
                               ANIMAL ID   | 2| 2| 2| 2| 2| 2| 2| 2| 2| 2|                                            |      A     |
    256                                    | 7| 7| 7| 7| 7| 7| 7| 7| 7| 8|                                            |      L     |
    MG/KG                                  | 1| 2| 3| 4| 5| 6| 7| 8| 9| 0|                                            |            |
 _____________________________________________________________________________________________________________________|____________|
 ALIMENTARY SYSTEM                         |                                                                          |            |
                                           |__________________________________________________________________________|____________|
   Intestine Large, Colon                  | +  +  +  +  +  +  +  +  +  +                                             |  10        |
                                           |__________________________________________________________________________|____________|
   Intestine Large, Cecum                  | +  +  +  +  +  +  +  +  +  +                                             |  10        |
                                           |__________________________________________________________________________|____________|
   Intestine Small, Duodenum               | +  +  +  +  +  +  +  +  +  +                                             |  10        |
                                           |__________________________________________________________________________|____________|
   Intestine Small, Jejunum                | +  +  +  +  +  +  +  +  +  +                                             |  10        |
                                           |__________________________________________________________________________|____________|
   Intestine Small, Ileum                  | +  +  +  +  +  +  +  +  +  +                                             |  10        |
                                           |__________________________________________________________________________|____________|
   Liver                                   | +  +  +  +  +  +  +  +  +  +                                             |  10        |
      Hematopoietic Cell Proliferation     |                1        1                                                |      2  1.0|
      Inflammation, Chronic Active         | 1  1  1  1     1  1  1  2  1                                             |      9  1.1|
      Necrosis                             |    1                       1                                             |      2  1.0|
      Hepatocyte, Vacuolization Cytoplasmic|    1  2  1  1  1  1  1     1                                             |      8  1.1|
                                           |__________________________________________________________________________|____________|
   Stomach, Forestomach                    | +  +  +  +  +  +  +  +  +  +                                             |  10        |
      Epithelium, Hyperkeratosis           |             1                                                            |      1  1.0|
      Epithelium, Hyperplasia              | 2           2                                                            |      2  2.0|
                                           |__________________________________________________________________________|____________|
   Tooth                                   | +     +                 +                                                |   3        |
 _____________________________________________________________________________________________________________________|            |
 CARDIOVASCULAR SYSTEM                     |                                                                          |            |
    None                                   |                                                                          |            |
 _____________________________________________________________________________________________________________________|            |
 ENDOCRINE SYSTEM                          |                                                                          |            |
                                           |__________________________________________________________________________|____________|
   Adrenal Cortex                          | +  +  +  +  +  +  +  +  +  +                                             |  10        |
      Accessory Adrenal Cortical Nodule    |             2  1        1  1                                             |      4  1.3|
      Subcapsular, Hyperplasia             |          1     1           1                                             |      3  1.0|
                                           |__________________________________________________________________________|____________|
   Adrenal Medulla                         | +  +  +  +  +  +  +  +  +  +                                             |  10        |
                                           |__________________________________________________________________________|____________|
 _____________________________________________________________________________________________________________________|____________|
  * : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade                         
  + : Tissue examined microscopically                M : Missing tissue                        1-4 : Lesion qualified as:           
  X : Lesion present but not qualified               A : Autolysis precludes examination               1) Minimal  3) Moderate      
  I : Insufficient tissue                        BLANK : Not examined                                  2) Mild     4) Marked        
                                                             Page  11                                                               
NTP Experiment-Test: 97013-92                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09  
Study Type: 26-39 WEEKS                         WATER DISINFECTION MODEL (SODIUM BROMATE)                         Date: 12/08/03    
Route: SKIN APPLICATION                                                                                           Time: 14:31:10    
 __________________________________________________________________________________________________________________________________ 
                                           | 2| 2| 2| 2| 2| 2| 2| 2| 2| 2|                                            |            |
                             DAY ON TEST   | 7| 1| 7| 7| 7| 7| 7| 7| 5| 7|                                            |            |
                                           | 2| 8| 2| 2| 2| 2| 2| 2| 7| 2|                                            |            |
 __________________________________________|__________________________________________________________________________|      T (*) |
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|                                            |      O     |
   TGAC (FVB/N) HEMIZYGOUS FEMALE          | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1|                                            |      T     |
                               ANIMAL ID   | 2| 2| 2| 2| 2| 2| 2| 2| 2| 2|                                            |      A     |
    256                                    | 7| 7| 7| 7| 7| 7| 7| 7| 7| 8|                                            |      L     |
    MG/KG                                  | 1| 2| 3| 4| 5| 6| 7| 8| 9| 0|                                            |            |
 _____________________________________________________________________________________________________________________|____________|
 ENDOCRINE SYSTEM - cont                   |                                                                          |            |
   Pituitary Gland                         | +  +  +  +  +  +  +  +  +  +                                             |  10        |
      Pars Distalis, Hypertrophy           |       2                                                                  |      1  2.0|
                                           |__________________________________________________________________________|____________|
   Thyroid Gland                           | +  +  +  +  +  +  +  +  +  +                                             |  10        |
      Infiltration Cellular, Lymphocyte    | 1  1  2  1  2  1  1  2  1  2                                             |     10  1.4|
      Follicle, Depletion Secretory        | 3  3  3  4  3  4  4  4  4  3                                             |     10  3.5|
      Follicular Cell, Hypertrophy         | 3  3  4  3  3  3  4  3  3  4                                             |     10  3.3|
 _____________________________________________________________________________________________________________________|            |
 GENERAL BODY SYSTEM                       |                                                                          |            |
    None                                   |                                                                          |            |
 _____________________________________________________________________________________________________________________|            |
 GENITAL SYSTEM                            |                                                                          |            |
                                           |__________________________________________________________________________|____________|
   Ovary                                   | +  +  +  +  +  +  +  +  +  +                                             |  10        |
      Cyst                                 | 2     2     3        2  2                                                |      5  2.2|
      Inflammation, Chronic Active         |             3                                                            |      1  3.0|
      Pigmentation, Hemosiderin            |       3                                                                  |      1  3.0|
      Corpus Luteum, Degeneration          |       4                                                                  |      1  4.0|
      Thecal Cell, Hyperplasia             |       3                                                                  |      1  3.0|
                                           |__________________________________________________________________________|____________|
   Uterus                                  | +  +  +  +  +  +  +  +  +  +                                             |  10        |
      Endometrium, Hyperplasia, Cystic     | 1  1  1  2  1  2  2  1  1  2                                             |     10  1.4|
 _____________________________________________________________________________________________________________________|            |
 HEMATOPOIETIC SYSTEM                      |                                                                          |            |
                                           |__________________________________________________________________________|____________|
   Lymph Node, Mandibular                  | +  +  +  +  +  +  +  +  +  +                                             |  10        |
      Hyperplasia, Lymphoid                | 2                       3                                                |      2  2.5|
                                           |__________________________________________________________________________|____________|
   Lymph Node, Mesenteric                  | +  +  +  +  +  +  +  +  +  +                                             |  10        |
                                           |__________________________________________________________________________|____________|
   Spleen                                  | +  +  +  +  +  +  +  +  +  +                                             |  10        |
      Hematopoietic Cell Proliferation     | 2     1  2     2  1  2  2  2                                             |      8  1.8|
                                           |__________________________________________________________________________|____________|
   Thymus                                  | +  +  +  +  +  +  +  +  +  +                                             |  10        |
 _____________________________________________________________________________________________________________________|____________|
  * : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade                         
  + : Tissue examined microscopically                M : Missing tissue                        1-4 : Lesion qualified as:           
  X : Lesion present but not qualified               A : Autolysis precludes examination               1) Minimal  3) Moderate      
  I : Insufficient tissue                        BLANK : Not examined                                  2) Mild     4) Marked        
                                                             Page  12                                                               
NTP Experiment-Test: 97013-92                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09  
Study Type: 26-39 WEEKS                         WATER DISINFECTION MODEL (SODIUM BROMATE)                         Date: 12/08/03    
Route: SKIN APPLICATION                                                                                           Time: 14:31:10    
 __________________________________________________________________________________________________________________________________ 
                                           | 2| 2| 2| 2| 2| 2| 2| 2| 2| 2|                                            |            |
                             DAY ON TEST   | 7| 1| 7| 7| 7| 7| 7| 7| 5| 7|                                            |            |
                                           | 2| 8| 2| 2| 2| 2| 2| 2| 7| 2|                                            |            |
 __________________________________________|__________________________________________________________________________|      T (*) |
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|                                            |      O     |
   TGAC (FVB/N) HEMIZYGOUS FEMALE          | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1|                                            |      T     |
                               ANIMAL ID   | 2| 2| 2| 2| 2| 2| 2| 2| 2| 2|                                            |      A     |
    256                                    | 7| 7| 7| 7| 7| 7| 7| 7| 7| 8|                                            |      L     |
    MG/KG                                  | 1| 2| 3| 4| 5| 6| 7| 8| 9| 0|                                            |            |
 _____________________________________________________________________________________________________________________|____________|
 HEMATOPOIETIC SYSTEM - cont               |                                                                          |            |
      Atrophy                              |                         3                                                |      1  3.0|
      Cyst                                 | 2           1  1        2  1                                             |      5  1.4|
 _____________________________________________________________________________________________________________________|            |
 INTEGUMENTARY SYSTEM                      |                                                                          |            |
                                           |__________________________________________________________________________|____________|
   Mammary Gland                           | +  +  +  +  +  +  +  +  +  +                                             |  10        |
                                           |__________________________________________________________________________|____________|
   Skin                                    | +  +  +  +  +  +  +  +  +  +                                             |  10        |
      Epidermis, Hyperplasia, Focal        |       2  2  2                                                            |      3  2.0|
      Site of Application - Dermis, Cyst   |                                                                          |            |
          Epithelial Inclusion             |             3                                                            |      1  3.0|
      Subcutaneous Tissue, Cyst Epithelial |                                                                          |            |
          Inclusion                        |                            3                                             |      1  3.0|
 _____________________________________________________________________________________________________________________|            |
 MUSCULOSKELETAL SYSTEM                    |                                                                          |            |
    None                                   |                                                                          |            |
 _____________________________________________________________________________________________________________________|            |
 NERVOUS SYSTEM                            |                                                                          |            |
    None                                   |                                                                          |            |
 _____________________________________________________________________________________________________________________|            |
 RESPIRATORY SYSTEM                        |                                                                          |            |
                                           |__________________________________________________________________________|____________|
   Lung                                    | +  +  +  +  +  +  +  +  +  +                                             |  10        |
      Metaplasia, Osseous                  |                         1                                                |      1  1.0|
      Perivascular, Infiltration Cellular, |                                                                          |            |
           Lymphocyte                      |    1                                                                     |      1  1.0|
 _____________________________________________________________________________________________________________________|            |
 SPECIAL SENSES SYSTEM                     |                                                                          |            |
    None                                   |                                                                          |            |
 _____________________________________________________________________________________________________________________|            |
 URINARY SYSTEM                            |                                                                          |            |
                                           |__________________________________________________________________________|____________|
   Kidney                                  | +  +  +  +  +  +  +  +  +  +                                             |  10        |
      Nephropathy                          | 1  1  2  2  1  1  2  1  1  1                                             |     10  1.3|
 _____________________________________________________________________________________________________________________|____________|
  * : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade                         
  + : Tissue examined microscopically                M : Missing tissue                        1-4 : Lesion qualified as:           
  X : Lesion present but not qualified               A : Autolysis precludes examination               1) Minimal  3) Moderate      
  I : Insufficient tissue                        BLANK : Not examined                                  2) Mild     4) Marked        
                                                             Page  13                                                               
NTP Experiment-Test: 97013-92                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09  
Study Type: 26-39 WEEKS                         WATER DISINFECTION MODEL (SODIUM BROMATE)                         Date: 12/08/03    
Route: SKIN APPLICATION                                                                                           Time: 14:31:10    
 __________________________________________________________________________________________________________________________________ 
                                           | 2| 2| 2| 2| 2| 2| 2| 2| 2| 2|                                            |            |
                             DAY ON TEST   | 7| 1| 7| 7| 7| 7| 7| 7| 5| 7|                                            |            |
                                           | 2| 8| 2| 2| 2| 2| 2| 2| 7| 2|                                            |            |
 __________________________________________|__________________________________________________________________________|      T (*) |
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|                                            |      O     |
   TGAC (FVB/N) HEMIZYGOUS FEMALE          | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1|                                            |      T     |
                               ANIMAL ID   | 2| 2| 2| 2| 2| 2| 2| 2| 2| 2|                                            |      A     |
    256                                    | 7| 7| 7| 7| 7| 7| 7| 7| 7| 8|                                            |      L     |
    MG/KG                                  | 1| 2| 3| 4| 5| 6| 7| 8| 9| 0|                                            |            |
 _____________________________________________________________________________________________________________________|____________|
 URINARY SYSTEM - cont                     |                                                                          |            |
      Renal Tubule, Hypertrophy            |    1     1        1     1                                                |      4  1.0|
 __________________________________________________________________________________________________________________________________ 
  * : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade                         
  + : Tissue examined microscopically                M : Missing tissue                        1-4 : Lesion qualified as:           
  X : Lesion present but not qualified               A : Autolysis precludes examination               1) Minimal  3) Moderate      
  I : Insufficient tissue                        BLANK : Not examined                                  2) Mild     4) Marked        
                                                             Page  14                                                               
NTP Experiment-Test: 97013-92                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09  
Study Type: 26-39 WEEKS                         WATER DISINFECTION MODEL (SODIUM BROMATE)                         Date: 12/08/03    
Route: SKIN APPLICATION                                                                                           Time: 14:31:10    
 __________________________________________________________________________________________________________________________________ 
                                           | 1| 2| 2| 2| 2| 2| 2| 2| 2| 2|                                            |            |
                             DAY ON TEST   | 3| 7| 7| 7| 7| 7| 7| 1| 7| 7|                                            |            |
                                           | 4| 2| 2| 2| 2| 2| 2| 8| 2| 2|                                            |            |
 __________________________________________|__________________________________________________________________________|      T (*) |
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|                                            |      O     |
   TGAC (FVB/N) HEMIZYGOUS MALE            | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1|                                            |      T     |
                               ANIMAL ID   | 2| 2| 2| 2| 2| 2| 2| 2| 2| 2|                                            |      A     |
    0 MG/KG                                | 0| 0| 0| 0| 0| 0| 0| 0| 0| 1|                                            |      L     |
                                           | 1| 2| 3| 4| 5| 6| 7| 8| 9| 0|                                            |            |
 _____________________________________________________________________________________________________________________|____________|
 ALIMENTARY SYSTEM                         |                                                                          |            |
                                           |__________________________________________________________________________|____________|
   Intestine Large, Colon                  | +  +  +  +  +  +  +  +  +  +                                             |  10        |
                                           |__________________________________________________________________________|____________|
   Intestine Large, Rectum                 |                      +                                                   |   1        |
                                           |__________________________________________________________________________|____________|
   Intestine Large, Cecum                  | +  +  +  +  +  +  +  +  +  +                                             |  10        |
                                           |__________________________________________________________________________|____________|
   Intestine Small, Duodenum               | +  +  +  +  +  +  +  +  +  +                                             |  10        |
                                           |__________________________________________________________________________|____________|
   Intestine Small, Jejunum                | +  +  +  +  +  +  +  +  +  +                                             |  10        |
                                           |__________________________________________________________________________|____________|
   Intestine Small, Ileum                  | +  +  +  +  +  +  +  +  +  +                                             |  10        |
                                           |__________________________________________________________________________|____________|
   Liver                                   | +  +  +  +  +  +  +  +  +  +                                             |  10        |
      Inflammation, Chronic Active         | 1  1     1  1  1  1     1  1                                             |      8  1.0|
      Hepatocyte, Fatty Change             |             1                                                            |      1  1.0|
      Hepatocyte, Vacuolization Cytoplasmic|       1     2     1  1  1                                                |      5  1.2|
                                           |__________________________________________________________________________|____________|
   Mesentery                               |             +                                                            |   1        |
      Fat, Fibrosis                        |             2                                                            |      1  2.0|
      Fat, Inflammation, Chronic Active    |             2                                                            |      1  2.0|
      Fat, Necrosis                        |             4                                                            |      1  4.0|
                                           |__________________________________________________________________________|____________|
   Salivary Glands                         | +     +                                                                  |   2        |
                                           |__________________________________________________________________________|____________|
   Stomach, Forestomach                    | +  +  +  +  +  +  +  +  +  +                                             |  10        |
                                           |__________________________________________________________________________|____________|
   Tooth                                   |    +     +                                                               |   2        |
 _____________________________________________________________________________________________________________________|            |
 CARDIOVASCULAR SYSTEM                     |                                                                          |            |
    None                                   |                                                                          |            |
 _____________________________________________________________________________________________________________________|            |
 ENDOCRINE SYSTEM                          |                                                                          |            |
                                           |__________________________________________________________________________|____________|
 _____________________________________________________________________________________________________________________|____________|
  * : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade                         
  + : Tissue examined microscopically                M : Missing tissue                        1-4 : Lesion qualified as:           
  X : Lesion present but not qualified               A : Autolysis precludes examination               1) Minimal  3) Moderate      
  I : Insufficient tissue                        BLANK : Not examined                                  2) Mild     4) Marked        
                                                             Page  15                                                               
NTP Experiment-Test: 97013-92                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09  
Study Type: 26-39 WEEKS                         WATER DISINFECTION MODEL (SODIUM BROMATE)                         Date: 12/08/03    
Route: SKIN APPLICATION                                                                                           Time: 14:31:10    
 __________________________________________________________________________________________________________________________________ 
                                           | 1| 2| 2| 2| 2| 2| 2| 2| 2| 2|                                            |            |
                             DAY ON TEST   | 3| 7| 7| 7| 7| 7| 7| 1| 7| 7|                                            |            |
                                           | 4| 2| 2| 2| 2| 2| 2| 8| 2| 2|                                            |            |
 __________________________________________|__________________________________________________________________________|      T (*) |
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|                                            |      O     |
   TGAC (FVB/N) HEMIZYGOUS MALE            | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1|                                            |      T     |
                               ANIMAL ID   | 2| 2| 2| 2| 2| 2| 2| 2| 2| 2|                                            |      A     |
    0 MG/KG                                | 0| 0| 0| 0| 0| 0| 0| 0| 0| 1|                                            |      L     |
                                           | 1| 2| 3| 4| 5| 6| 7| 8| 9| 0|                                            |            |
 _____________________________________________________________________________________________________________________|____________|
 ENDOCRINE SYSTEM - cont                   |                                                                          |            |
   Adrenal Cortex                          | +  +  +  +  +  +  +  +  +  +                                             |  10        |
      Hypertrophy                          |       1  1  2  2  1        2                                             |      6  1.5|
                                           |__________________________________________________________________________|____________|
   Adrenal Medulla                         | +  +  +  +  +  +  +  +  +  +                                             |  10        |
                                           |__________________________________________________________________________|____________|
   Pituitary Gland                         | +  +  +  +  +  +  +  +  +  M                                             |   9        |
      Pars Distalis, Cyst                  |       1     1     1                                                      |      3  1.0|
                                           |__________________________________________________________________________|____________|
   Thyroid Gland                           | +  +  +  +  +  +  +  +  +  +                                             |  10        |
      Follicle, Depletion Secretory        |    1  1  1  1  1     1  1  1                                             |      8  1.0|
 _____________________________________________________________________________________________________________________|            |
 GENERAL BODY SYSTEM                       |                                                                          |            |
    None                                   |                                                                          |            |
 _____________________________________________________________________________________________________________________|            |
 GENITAL SYSTEM                            |                                                                          |            |
                                           |__________________________________________________________________________|____________|
   Epididymis                              | +  +  +  +  +  +  +  +  +  +                                             |  10        |
      Degeneration                         |          4                                                               |      1  4.0|
                                           |__________________________________________________________________________|____________|
   Testes                                  | +  +  +  +  +  +  +  +  +  +                                             |  10        |
      Germinal Epithelium, Degeneration    |          3                                                               |      1  3.0|
 _____________________________________________________________________________________________________________________|            |
 HEMATOPOIETIC SYSTEM                      |                                                                          |            |
                                           |__________________________________________________________________________|____________|
   Lymph Node, Mandibular                  | +  +  +  +  +  +  +  +  +  +                                             |  10        |
      Hyperplasia, Lymphoid                |                3                                                         |      1  3.0|
                                           |__________________________________________________________________________|____________|
   Lymph Node, Mesenteric                  | +  +  +  +  +  +  +  +  +  +                                             |  10        |
                                           |__________________________________________________________________________|____________|
   Spleen                                  | +  +  +  +  +  +  +  +  +  +                                             |  10        |
      Hematopoietic Cell Proliferation     | 2     2     2                                                            |      3  2.0|
                                           |__________________________________________________________________________|____________|
   Thymus                                  | +  +  +  +  +  +  +  +  +  +                                             |  10        |
      Atrophy                              |    2  2                    2                                             |      3  2.0|
 _____________________________________________________________________________________________________________________|____________|
  * : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade                         
  + : Tissue examined microscopically                M : Missing tissue                        1-4 : Lesion qualified as:           
  X : Lesion present but not qualified               A : Autolysis precludes examination               1) Minimal  3) Moderate      
  I : Insufficient tissue                        BLANK : Not examined                                  2) Mild     4) Marked        
                                                             Page  16                                                               
NTP Experiment-Test: 97013-92                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09  
Study Type: 26-39 WEEKS                         WATER DISINFECTION MODEL (SODIUM BROMATE)                         Date: 12/08/03    
Route: SKIN APPLICATION                                                                                           Time: 14:31:10    
 __________________________________________________________________________________________________________________________________ 
                                           | 1| 2| 2| 2| 2| 2| 2| 2| 2| 2|                                            |            |
                             DAY ON TEST   | 3| 7| 7| 7| 7| 7| 7| 1| 7| 7|                                            |            |
                                           | 4| 2| 2| 2| 2| 2| 2| 8| 2| 2|                                            |            |
 __________________________________________|__________________________________________________________________________|      T (*) |
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|                                            |      O     |
   TGAC (FVB/N) HEMIZYGOUS MALE            | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1|                                            |      T     |
                               ANIMAL ID   | 2| 2| 2| 2| 2| 2| 2| 2| 2| 2|                                            |      A     |
    0 MG/KG                                | 0| 0| 0| 0| 0| 0| 0| 0| 0| 1|                                            |      L     |
                                           | 1| 2| 3| 4| 5| 6| 7| 8| 9| 0|                                            |            |
 _____________________________________________________________________________________________________________________|____________|
 HEMATOPOIETIC SYSTEM - cont               |                                                                          |            |
      Cyst                                 |    1  1  1        1  1  1  1                                             |      7  1.0|
 _____________________________________________________________________________________________________________________|            |
 INTEGUMENTARY SYSTEM                      |                                                                          |            |
                                           |__________________________________________________________________________|____________|
   Mammary Gland                           | M  M  M  M  M  M  M  +  M  M                                             |   1        |
                                           |__________________________________________________________________________|____________|
   Skin                                    | +  +  +  +  +  +  +  +  +  +                                             |  10        |
      Epidermis, Hyperplasia, Focal        |       3  2           2     3                                             |      4  2.5|
      Subcutaneous Tissue, Inflammation,   |                                                                          |            |
           Chronic Active                  | 4                                                                        |      1  4.0|
 _____________________________________________________________________________________________________________________|            |
 MUSCULOSKELETAL SYSTEM                    |                                                                          |            |
    None                                   |                                                                          |            |
 _____________________________________________________________________________________________________________________|            |
 NERVOUS SYSTEM                            |                                                                          |            |
    None                                   |                                                                          |            |
 _____________________________________________________________________________________________________________________|            |
 RESPIRATORY SYSTEM                        |                                                                          |            |
                                           |__________________________________________________________________________|____________|
   Lung                                    | +  +  +  +  +  +  +  +  +  +                                             |  10        |
 _____________________________________________________________________________________________________________________|            |
 SPECIAL SENSES SYSTEM                     |                                                                          |            |
    None                                   |                                                                          |            |
 _____________________________________________________________________________________________________________________|            |
 URINARY SYSTEM                            |                                                                          |            |
                                           |__________________________________________________________________________|____________|
   Kidney                                  | +  +  +  +  +  +  +  +  +  +                                             |  10        |
      Nephropathy                          |    1  1     1  1  1     1  1                                             |      7  1.0|
      Papilla, Mineralization              |                   1                                                      |      1  1.0|
 __________________________________________________________________________________________________________________________________ 
  * : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade                         
  + : Tissue examined microscopically                M : Missing tissue                        1-4 : Lesion qualified as:           
  X : Lesion present but not qualified               A : Autolysis precludes examination               1) Minimal  3) Moderate      
  I : Insufficient tissue                        BLANK : Not examined                                  2) Mild     4) Marked        
                                                             Page  17                                                               
NTP Experiment-Test: 97013-92                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09  
Study Type: 26-39 WEEKS                         WATER DISINFECTION MODEL (SODIUM BROMATE)                         Date: 12/08/03    
Route: SKIN APPLICATION                                                                                           Time: 14:31:10    
 __________________________________________________________________________________________________________________________________ 
                                           | 2| 2| 2| 1| 2| 2| 2| 2| 2| 2|                                            |            |
                             DAY ON TEST   | 7| 7| 7| 4| 7| 7| 7| 5| 7| 7|                                            |            |
                                           | 2| 2| 2| 0| 2| 2| 2| 1| 2| 2|                                            |            |
 __________________________________________|__________________________________________________________________________|      T (*) |
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|                                            |      O     |
   TGAC (FVB/N) HEMIZYGOUS MALE            | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1|                                            |      T     |
                               ANIMAL ID   | 2| 2| 2| 2| 2| 2| 2| 2| 2| 2|                                            |      A     |
    64 MG/KG                               | 1| 1| 1| 1| 1| 1| 1| 1| 1| 2|                                            |      L     |
                                           | 1| 2| 3| 4| 5| 6| 7| 8| 9| 0|                                            |            |
 _____________________________________________________________________________________________________________________|____________|
 ALIMENTARY SYSTEM                         |                                                                          |            |
                                           |__________________________________________________________________________|____________|
   Intestine Large, Colon                  | +  +  +  +  +  +  +  +  +  +                                             |  10        |
                                           |__________________________________________________________________________|____________|
   Intestine Large, Cecum                  | +  +  +  +  +  +  +  +  +  +                                             |  10        |
                                           |__________________________________________________________________________|____________|
   Intestine Small, Duodenum               | +  +  +  +  +  +  +  +  +  +                                             |  10        |
                                           |__________________________________________________________________________|____________|
   Intestine Small, Jejunum                | +  +  +  +  +  +  +  +  +  +                                             |  10        |
                                           |__________________________________________________________________________|____________|
   Intestine Small, Ileum                  | +  +  +  +  +  +  +  +  +  +                                             |  10        |
                                           |__________________________________________________________________________|____________|
   Liver                                   | +  +  +  +  +  +  +  +  +  +                                             |  10        |
      Hematopoietic Cell Proliferation     | 1                                                                        |      1  1.0|
      Inflammation, Chronic Active         | 1  1  1     1  1  1     1  1                                             |      8  1.0|
      Hepatocyte, Vacuolization Cytoplasmic|    2     1  1  1  1  1  1  1                                             |      8  1.1|
                                           |__________________________________________________________________________|____________|
   Stomach, Forestomach                    | +  +  +  +  +  +  +  +  +  +                                             |  10        |
      Epithelium, Hyperkeratosis           |       1                    1                                             |      2  1.0|
      Epithelium, Hyperplasia              |       2                    1                                             |      2  1.5|
                                           |__________________________________________________________________________|____________|
   Tooth                                   | +  +  +                                                                  |   3        |
 _____________________________________________________________________________________________________________________|            |
 CARDIOVASCULAR SYSTEM                     |                                                                          |            |
    None                                   |                                                                          |            |
 _____________________________________________________________________________________________________________________|            |
 ENDOCRINE SYSTEM                          |                                                                          |            |
                                           |__________________________________________________________________________|____________|
   Adrenal Cortex                          | +  +  +  +  +  +  +  +  +  +                                             |  10        |
      Hypertrophy                          | 1     1        1  1        2                                             |      5  1.2|
                                           |__________________________________________________________________________|____________|
   Adrenal Medulla                         | +  +  +  +  +  +  +  +  +  +                                             |  10        |
                                           |__________________________________________________________________________|____________|
   Pituitary Gland                         | +  +  +  +  +  +  +  +  +  +                                             |  10        |
      Pars Distalis, Cyst                  |       1        1        1                                                |      3  1.0|
 _____________________________________________________________________________________________________________________|____________|
  * : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade                         
  + : Tissue examined microscopically                M : Missing tissue                        1-4 : Lesion qualified as:           
  X : Lesion present but not qualified               A : Autolysis precludes examination               1) Minimal  3) Moderate      
  I : Insufficient tissue                        BLANK : Not examined                                  2) Mild     4) Marked        
                                                             Page  18                                                               
NTP Experiment-Test: 97013-92                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09  
Study Type: 26-39 WEEKS                         WATER DISINFECTION MODEL (SODIUM BROMATE)                         Date: 12/08/03    
Route: SKIN APPLICATION                                                                                           Time: 14:31:10    
 __________________________________________________________________________________________________________________________________ 
                                           | 2| 2| 2| 1| 2| 2| 2| 2| 2| 2|                                            |            |
                             DAY ON TEST   | 7| 7| 7| 4| 7| 7| 7| 5| 7| 7|                                            |            |
                                           | 2| 2| 2| 0| 2| 2| 2| 1| 2| 2|                                            |            |
 __________________________________________|__________________________________________________________________________|      T (*) |
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|                                            |      O     |
   TGAC (FVB/N) HEMIZYGOUS MALE            | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1|                                            |      T     |
                               ANIMAL ID   | 2| 2| 2| 2| 2| 2| 2| 2| 2| 2|                                            |      A     |
    64 MG/KG                               | 1| 1| 1| 1| 1| 1| 1| 1| 1| 2|                                            |      L     |
                                           | 1| 2| 3| 4| 5| 6| 7| 8| 9| 0|                                            |            |
 _____________________________________________________________________________________________________________________|____________|
 ENDOCRINE SYSTEM - cont                   |                                                                          |            |
                                           |__________________________________________________________________________|____________|
   Thyroid Gland                           | +  +  +  +  +  +  +  +  +  +                                             |  10        |
      Follicle, Cyst                       |                         2                                                |      1  2.0|
      Follicle, Depletion Secretory        | 1  1  1     1  1  1  1                                                   |      7  1.0|
      Follicular Cell, Hypertrophy         | 1  1  1     1  1  1  1  1  1                                             |      9  1.0|
 _____________________________________________________________________________________________________________________|            |
 GENERAL BODY SYSTEM                       |                                                                          |            |
    None                                   |                                                                          |            |
 _____________________________________________________________________________________________________________________|            |
 GENITAL SYSTEM                            |                                                                          |            |
                                           |__________________________________________________________________________|____________|
   Epididymis                              | +  +  +  +  +  +  +  +  +  +                                             |  10        |
      Degeneration                         |          4  2                                                            |      2  3.0|
                                           |__________________________________________________________________________|____________|
   Penis                                   |             +                                                            |   1        |
                                           |__________________________________________________________________________|____________|
   Testes                                  | +  +  +  +  +  +  +  +  +  +                                             |  10        |
      Cyst                                 |          2                                                               |      1  2.0|
      Bilateral, Germinal Epithelium,      |                                                                          |            |
          Degeneration                     |             3                                                            |      1  3.0|
      Germinal Epithelium, Degeneration    |          2        1                                                      |      2  1.5|
 _____________________________________________________________________________________________________________________|            |
 HEMATOPOIETIC SYSTEM                      |                                                                          |            |
                                           |__________________________________________________________________________|____________|
   Lymph Node, Mandibular                  | +  +  +  +  +  +  +  +  +  +                                             |  10        |
                                           |__________________________________________________________________________|____________|
   Lymph Node, Mesenteric                  | +  +  +  +  +  +  +  +  +  +                                             |  10        |
                                           |__________________________________________________________________________|____________|
   Spleen                                  | +  +  +  +  +  +  +  +  +  +                                             |  10        |
      Hematopoietic Cell Proliferation     | 2                          2                                             |      2  2.0|
                                           |__________________________________________________________________________|____________|
   Thymus                                  | +  +  +  +  +  +  +  +  +  +                                             |  10        |
      Atrophy                              |    2     3                                                               |      2  2.5|
      Cyst                                 |                            2                                             |      1  2.0|
 _____________________________________________________________________________________________________________________|____________|
  * : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade                         
  + : Tissue examined microscopically                M : Missing tissue                        1-4 : Lesion qualified as:           
  X : Lesion present but not qualified               A : Autolysis precludes examination               1) Minimal  3) Moderate      
  I : Insufficient tissue                        BLANK : Not examined                                  2) Mild     4) Marked        
                                                             Page  19                                                               
NTP Experiment-Test: 97013-92                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09  
Study Type: 26-39 WEEKS                         WATER DISINFECTION MODEL (SODIUM BROMATE)                         Date: 12/08/03    
Route: SKIN APPLICATION                                                                                           Time: 14:31:10    
 __________________________________________________________________________________________________________________________________ 
                                           | 2| 2| 2| 1| 2| 2| 2| 2| 2| 2|                                            |            |
                             DAY ON TEST   | 7| 7| 7| 4| 7| 7| 7| 5| 7| 7|                                            |            |
                                           | 2| 2| 2| 0| 2| 2| 2| 1| 2| 2|                                            |            |
 __________________________________________|__________________________________________________________________________|      T (*) |
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|                                            |      O     |
   TGAC (FVB/N) HEMIZYGOUS MALE            | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1|                                            |      T     |
                               ANIMAL ID   | 2| 2| 2| 2| 2| 2| 2| 2| 2| 2|                                            |      A     |
    64 MG/KG                               | 1| 1| 1| 1| 1| 1| 1| 1| 1| 2|                                            |      L     |
                                           | 1| 2| 3| 4| 5| 6| 7| 8| 9| 0|                                            |            |
 _____________________________________________________________________________________________________________________|____________|
 INTEGUMENTARY SYSTEM                      |                                                                          |            |
                                           |__________________________________________________________________________|____________|
   Mammary Gland                           | M  M  M  M  M  +  M  M  M  M                                             |   1        |
                                           |__________________________________________________________________________|____________|
   Skin                                    | +  +  +  +  +  +  +  +  +  +                                             |  10        |
      Hyperkeratosis                       |                      2                                                   |      1  2.0|
      Epidermis, Hyperplasia, Focal        |                   1  3                                                   |      2  2.0|
 _____________________________________________________________________________________________________________________|            |
 MUSCULOSKELETAL SYSTEM                    |                                                                          |            |
    None                                   |                                                                          |            |
 _____________________________________________________________________________________________________________________|            |
 NERVOUS SYSTEM                            |                                                                          |            |
    None                                   |                                                                          |            |
 _____________________________________________________________________________________________________________________|            |
 RESPIRATORY SYSTEM                        |                                                                          |            |
                                           |__________________________________________________________________________|____________|
   Lung                                    | +  +  +  +  +  +  +  +  +  +                                             |  10        |
      Inflammation, Chronic Active         |    1  1                                                                  |      2  1.0|
      Alveolar Epithelium, Hyperplasia     |             1                                                            |      1  1.0|
 _____________________________________________________________________________________________________________________|            |
 SPECIAL SENSES SYSTEM                     |                                                                          |            |
    None                                   |                                                                          |            |
 _____________________________________________________________________________________________________________________|            |
 URINARY SYSTEM                            |                                                                          |            |
                                           |__________________________________________________________________________|____________|
   Kidney                                  | +  +  +  +  +  +  +  +  +  +                                             |  10        |
      Mineralization                       |                            1                                             |      1  1.0|
      Nephropathy                          | 1  1  1  2  1  1  1  1  1  1                                             |     10  1.1|
      Cortex, Cyst                         |                   2     2  1                                             |      3  1.7|
      Glomerulus, Inflammation,            |                                                                          |            |
          Membranoproliferative            |          3                                                               |      1  3.0|
 __________________________________________________________________________________________________________________________________ 
  * : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade                         
  + : Tissue examined microscopically                M : Missing tissue                        1-4 : Lesion qualified as:           
  X : Lesion present but not qualified               A : Autolysis precludes examination               1) Minimal  3) Moderate      
  I : Insufficient tissue                        BLANK : Not examined                                  2) Mild     4) Marked        
                                                             Page  20                                                               
NTP Experiment-Test: 97013-92                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09  
Study Type: 26-39 WEEKS                         WATER DISINFECTION MODEL (SODIUM BROMATE)                         Date: 12/08/03    
Route: SKIN APPLICATION                                                                                           Time: 14:31:10    
 __________________________________________________________________________________________________________________________________ 
                                           | 2| 2| 2| 2| 2| 2| 2| 2| 2| 2|                                            |            |
                             DAY ON TEST   | 5| 7| 7| 7| 7| 7| 7| 7| 2| 7|                                            |            |
                                           | 1| 2| 2| 2| 2| 2| 2| 2| 1| 2|                                            |            |
 __________________________________________|__________________________________________________________________________|      T (*) |
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|                                            |      O     |
   TGAC (FVB/N) HEMIZYGOUS MALE            | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1|                                            |      T     |
                               ANIMAL ID   | 2| 2| 2| 2| 2| 2| 2| 2| 2| 2|                                            |      A     |
    128                                    | 2| 2| 2| 2| 2| 2| 2| 2| 2| 3|                                            |      L     |
    MG/KG                                  | 1| 2| 3| 4| 5| 6| 7| 8| 9| 0|                                            |            |
 _____________________________________________________________________________________________________________________|____________|
 ALIMENTARY SYSTEM                         |                                                                          |            |
                                           |__________________________________________________________________________|____________|
   Intestine Large, Colon                  | +  +  +  +  +  +  +  +  +  +                                             |  10        |
                                           |__________________________________________________________________________|____________|
   Intestine Large, Cecum                  | +  +  +  +  +  +  +  +  +  +                                             |  10        |
                                           |__________________________________________________________________________|____________|
   Intestine Small, Duodenum               | +  +  +  +  +  +  +  +  +  +                                             |  10        |
                                           |__________________________________________________________________________|____________|
   Intestine Small, Jejunum                | +  +  +  +  +  +  +  +  +  +                                             |  10        |
                                           |__________________________________________________________________________|____________|
   Intestine Small, Ileum                  | +  +  +  +  +  +  +  +  +  +                                             |  10        |
                                           |__________________________________________________________________________|____________|
   Liver                                   | +  +  +  +  +  +  +  +  +  +                                             |  10        |
      Hematopoietic Cell Proliferation     |                1                                                         |      1  1.0|
      Inflammation, Chronic Active         |       1  1     1  1     1  1                                             |      6  1.0|
      Hepatocyte, Vacuolization Cytoplasmic|    1  1  1        1  1     1                                             |      6  1.0|
                                           |__________________________________________________________________________|____________|
   Mesentery                               |    +           +                                                         |   2        |
      Fat, Fibrosis                        |                3                                                         |      1  3.0|
      Fat, Inflammation, Chronic Active    |    2           2                                                         |      2  2.0|
      Fat, Necrosis                        |    4           4                                                         |      2  4.0|
                                           |__________________________________________________________________________|____________|
   Stomach, Forestomach                    | +  +  +  +  +  +  +  +  +  +                                             |  10        |
                                           |__________________________________________________________________________|____________|
   Tooth                                   |          +  +  +                                                         |   3        |
 _____________________________________________________________________________________________________________________|            |
 CARDIOVASCULAR SYSTEM                     |                                                                          |            |
    None                                   |                                                                          |            |
 _____________________________________________________________________________________________________________________|            |
 ENDOCRINE SYSTEM                          |                                                                          |            |
                                           |__________________________________________________________________________|____________|
   Adrenal Cortex                          | +  +  +  +  +  +  +  +  +  +                                             |  10        |
      Accessory Adrenal Cortical Nodule    |          2           1                                                   |      2  1.5|
      Hypertrophy                          |    2  1     1     2  2     2                                             |      6  1.7|
                                           |__________________________________________________________________________|____________|
 _____________________________________________________________________________________________________________________|____________|
  * : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade                         
  + : Tissue examined microscopically                M : Missing tissue                        1-4 : Lesion qualified as:           
  X : Lesion present but not qualified               A : Autolysis precludes examination               1) Minimal  3) Moderate      
  I : Insufficient tissue                        BLANK : Not examined                                  2) Mild     4) Marked        
                                                             Page  21                                                               
NTP Experiment-Test: 97013-92                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09  
Study Type: 26-39 WEEKS                         WATER DISINFECTION MODEL (SODIUM BROMATE)                         Date: 12/08/03    
Route: SKIN APPLICATION                                                                                           Time: 14:31:10    
 __________________________________________________________________________________________________________________________________ 
                                           | 2| 2| 2| 2| 2| 2| 2| 2| 2| 2|                                            |            |
                             DAY ON TEST   | 5| 7| 7| 7| 7| 7| 7| 7| 2| 7|                                            |            |
                                           | 1| 2| 2| 2| 2| 2| 2| 2| 1| 2|                                            |            |
 __________________________________________|__________________________________________________________________________|      T (*) |
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|                                            |      O     |
   TGAC (FVB/N) HEMIZYGOUS MALE            | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1|                                            |      T     |
                               ANIMAL ID   | 2| 2| 2| 2| 2| 2| 2| 2| 2| 2|                                            |      A     |
    128                                    | 2| 2| 2| 2| 2| 2| 2| 2| 2| 3|                                            |      L     |
    MG/KG                                  | 1| 2| 3| 4| 5| 6| 7| 8| 9| 0|                                            |            |
 _____________________________________________________________________________________________________________________|____________|
 ENDOCRINE SYSTEM - cont                   |                                                                          |            |
   Adrenal Medulla                         | +  +  +  +  +  +  +  +  +  +                                             |  10        |
                                           |__________________________________________________________________________|____________|
   Pituitary Gland                         | +  +  +  +  +  +  +  +  +  +                                             |  10        |
      Pars Distalis, Cyst                  |                         1                                                |      1  1.0|
                                           |__________________________________________________________________________|____________|
   Thyroid Gland                           | +  +  +  +  +  +  +  +  +  +                                             |  10        |
      Infiltration Cellular, Lymphocyte    |                   1        1                                             |      2  1.0|
      Follicle, Depletion Secretory        |    1  1  1  2  2  2  1  1  1                                             |      9  1.3|
      Follicular Cell, Hypertrophy         |    1  1  2     2  2  2  1  1                                             |      8  1.5|
 _____________________________________________________________________________________________________________________|            |
 GENERAL BODY SYSTEM                       |                                                                          |            |
    None                                   |                                                                          |            |
 _____________________________________________________________________________________________________________________|            |
 GENITAL SYSTEM                            |                                                                          |            |
                                           |__________________________________________________________________________|____________|
   Epididymis                              | +  +  +  +  +  +  +  +  +  +                                             |  10        |
      Cyst                                 |    X        X                                                            |      2     |
      Degeneration                         |    4        4  4                                                         |      3  4.0|
      Inflammation, Chronic Active         |    2        2        2                                                   |      3  2.0|
                                           |__________________________________________________________________________|____________|
   Testes                                  | +  +  +  +  +  +  +  +  +  +                                             |  10        |
      Cyst                                 |    2                                                                     |      1  2.0|
      Mineralization                       |                1                                                         |      1  1.0|
      Bilateral, Germinal Epithelium,      |                                                                          |            |
          Degeneration                     |                3                                                         |      1  3.0|
      Germinal Epithelium, Degeneration    |    4     1  4                                                            |      3  3.0|
 _____________________________________________________________________________________________________________________|            |
 HEMATOPOIETIC SYSTEM                      |                                                                          |            |
                                           |__________________________________________________________________________|____________|
   Lymph Node, Mandibular                  | +  +  +  +  +  +  +  +  +  +                                             |  10        |
                                           |__________________________________________________________________________|____________|
   Lymph Node, Mesenteric                  | +  +  +  +  +  +  +  +  +  +                                             |  10        |
                                           |__________________________________________________________________________|____________|
   Spleen                                  | +  +  +  +  +  +  +  +  +  +                                             |  10        |
 _____________________________________________________________________________________________________________________|____________|
  * : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade                         
  + : Tissue examined microscopically                M : Missing tissue                        1-4 : Lesion qualified as:           
  X : Lesion present but not qualified               A : Autolysis precludes examination               1) Minimal  3) Moderate      
  I : Insufficient tissue                        BLANK : Not examined                                  2) Mild     4) Marked        
                                                             Page  22                                                               
NTP Experiment-Test: 97013-92                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09  
Study Type: 26-39 WEEKS                         WATER DISINFECTION MODEL (SODIUM BROMATE)                         Date: 12/08/03    
Route: SKIN APPLICATION                                                                                           Time: 14:31:10    
 __________________________________________________________________________________________________________________________________ 
                                           | 2| 2| 2| 2| 2| 2| 2| 2| 2| 2|                                            |            |
                             DAY ON TEST   | 5| 7| 7| 7| 7| 7| 7| 7| 2| 7|                                            |            |
                                           | 1| 2| 2| 2| 2| 2| 2| 2| 1| 2|                                            |            |
 __________________________________________|__________________________________________________________________________|      T (*) |
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|                                            |      O     |
   TGAC (FVB/N) HEMIZYGOUS MALE            | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1|                                            |      T     |
                               ANIMAL ID   | 2| 2| 2| 2| 2| 2| 2| 2| 2| 2|                                            |      A     |
    128                                    | 2| 2| 2| 2| 2| 2| 2| 2| 2| 3|                                            |      L     |
    MG/KG                                  | 1| 2| 3| 4| 5| 6| 7| 8| 9| 0|                                            |            |
 _____________________________________________________________________________________________________________________|____________|
 HEMATOPOIETIC SYSTEM - cont               |                                                                          |            |
      Hematopoietic Cell Proliferation     |       2        3                                                         |      2  2.5|
                                           |__________________________________________________________________________|____________|
   Thymus                                  | +  +  +  +  +  +  +  +  +  +                                             |  10        |
      Atrophy                              | 4  4           3     2                                                   |      4  3.3|
 _____________________________________________________________________________________________________________________|            |
 INTEGUMENTARY SYSTEM                      |                                                                          |            |
                                           |__________________________________________________________________________|____________|
   Mammary Gland                           | M  +  M  M  M  M  M  M  M  M                                             |   1        |
                                           |__________________________________________________________________________|____________|
   Skin                                    | +  +  +  +  +  +  +  +  +  +                                             |  10        |
      Epidermis, Hyperplasia, Focal        |    2                                                                     |      1  2.0|
      Site of Application - Epidermis,     |                                                                          |            |
           Hyperplasia, Focal              |                      1                                                   |      1  1.0|
 _____________________________________________________________________________________________________________________|            |
 MUSCULOSKELETAL SYSTEM                    |                                                                          |            |
    None                                   |                                                                          |            |
 _____________________________________________________________________________________________________________________|            |
 NERVOUS SYSTEM                            |                                                                          |            |
    None                                   |                                                                          |            |
 _____________________________________________________________________________________________________________________|            |
 RESPIRATORY SYSTEM                        |                                                                          |            |
                                           |__________________________________________________________________________|____________|
   Lung                                    | +  +  +  +  +  +  +  +  +  +                                             |  10        |
      Inflammation, Chronic Active         |    1                                                                     |      1  1.0|
 _____________________________________________________________________________________________________________________|            |
 SPECIAL SENSES SYSTEM                     |                                                                          |            |
    None                                   |                                                                          |            |
 _____________________________________________________________________________________________________________________|            |
 URINARY SYSTEM                            |                                                                          |            |
                                           |__________________________________________________________________________|____________|
   Kidney                                  | +  +  +  +  +  +  +  +  +  +                                             |  10        |
      Nephropathy                          |    1  1  1  1  1  1  1  2  1                                             |      9  1.1|
      Cortex, Cyst                         |                1                                                         |      1  1.0|
      Glomerulus, Inflammation,            |                                                                          |            |
 _____________________________________________________________________________________________________________________|____________|
  * : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade                         
  + : Tissue examined microscopically                M : Missing tissue                        1-4 : Lesion qualified as:           
  X : Lesion present but not qualified               A : Autolysis precludes examination               1) Minimal  3) Moderate      
  I : Insufficient tissue                        BLANK : Not examined                                  2) Mild     4) Marked        
                                                             Page  23                                                               
NTP Experiment-Test: 97013-92                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09  
Study Type: 26-39 WEEKS                         WATER DISINFECTION MODEL (SODIUM BROMATE)                         Date: 12/08/03    
Route: SKIN APPLICATION                                                                                           Time: 14:31:10    
 __________________________________________________________________________________________________________________________________ 
                                           | 2| 2| 2| 2| 2| 2| 2| 2| 2| 2|                                            |            |
                             DAY ON TEST   | 5| 7| 7| 7| 7| 7| 7| 7| 2| 7|                                            |            |
                                           | 1| 2| 2| 2| 2| 2| 2| 2| 1| 2|                                            |            |
 __________________________________________|__________________________________________________________________________|      T (*) |
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|                                            |      O     |
   TGAC (FVB/N) HEMIZYGOUS MALE            | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1|                                            |      T     |
                               ANIMAL ID   | 2| 2| 2| 2| 2| 2| 2| 2| 2| 2|                                            |      A     |
    128                                    | 2| 2| 2| 2| 2| 2| 2| 2| 2| 3|                                            |      L     |
    MG/KG                                  | 1| 2| 3| 4| 5| 6| 7| 8| 9| 0|                                            |            |
 _____________________________________________________________________________________________________________________|____________|
 URINARY SYSTEM - cont                     |                                                                          |            |
          Membranoproliferative            | 4                                                                        |      1  4.0|
 __________________________________________________________________________________________________________________________________ 
  * : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade                         
  + : Tissue examined microscopically                M : Missing tissue                        1-4 : Lesion qualified as:           
  X : Lesion present but not qualified               A : Autolysis precludes examination               1) Minimal  3) Moderate      
  I : Insufficient tissue                        BLANK : Not examined                                  2) Mild     4) Marked        
                                                             Page  24                                                               
NTP Experiment-Test: 97013-92                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09  
Study Type: 26-39 WEEKS                         WATER DISINFECTION MODEL (SODIUM BROMATE)                         Date: 12/08/03    
Route: SKIN APPLICATION                                                                                           Time: 14:31:10    
 __________________________________________________________________________________________________________________________________ 
                                           | 2| 2| 2| 2| 2| 2| 0| 2| 2| 2|                                            |            |
                             DAY ON TEST   | 7| 7| 7| 7| 7| 7| 6| 2| 7| 7|                                            |            |
                                           | 2| 2| 2| 2| 2| 2| 9| 1| 2| 2|                                            |            |
 __________________________________________|__________________________________________________________________________|      T (*) |
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|                                            |      O     |
   TGAC (FVB/N) HEMIZYGOUS MALE            | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1|                                            |      T     |
                               ANIMAL ID   | 2| 2| 2| 2| 2| 2| 2| 2| 2| 2|                                            |      A     |
    256                                    | 3| 3| 3| 3| 3| 3| 3| 3| 3| 4|                                            |      L     |
    MG/KG                                  | 1| 2| 3| 4| 5| 6| 7| 8| 9| 0|                                            |            |
 _____________________________________________________________________________________________________________________|____________|
 ALIMENTARY SYSTEM                         |                                                                          |            |
                                           |__________________________________________________________________________|____________|
   Intestine Large, Colon                  | +  +  +  +  +  +  +  +  +  +                                             |  10        |
                                           |__________________________________________________________________________|____________|
   Intestine Large, Cecum                  | +  +  +  +  +  +  +  +  +  +                                             |  10        |
                                           |__________________________________________________________________________|____________|
   Intestine Small, Duodenum               | +  +  +  +  +  +  +  +  +  +                                             |  10        |
                                           |__________________________________________________________________________|____________|
   Intestine Small, Jejunum                | +  +  +  +  +  +  +  +  +  +                                             |  10        |
                                           |__________________________________________________________________________|____________|
   Intestine Small, Ileum                  | +  +  +  +  +  +  +  +  +  +                                             |  10        |
                                           |__________________________________________________________________________|____________|
   Liver                                   | +  +  +  +  +  +  +  +  +  +                                             |  10        |
      Hematopoietic Cell Proliferation     |                      1                                                   |      1  1.0|
      Inflammation, Chronic Active         | 2        1     1     1  1  1                                             |      6  1.2|
      Necrosis                             |    1  1                                                                  |      2  1.0|
      Hepatocyte, Vacuolization Cytoplasmic|       1  1                                                               |      2  1.0|
                                           |__________________________________________________________________________|____________|
   Stomach, Forestomach                    | +  +  +  +  +  +  +  +  +  +                                             |  10        |
      Epithelium, Hyperkeratosis           |                      2                                                   |      1  2.0|
      Epithelium, Hyperplasia              |                      2                                                   |      1  2.0|
                                           |__________________________________________________________________________|____________|
   Tooth                                   | +                    +                                                   |   2        |
      Abscess, Focal                       | X                                                                        |      1     |
 _____________________________________________________________________________________________________________________|            |
 CARDIOVASCULAR SYSTEM                     |                                                                          |            |
    None                                   |                                                                          |            |
 _____________________________________________________________________________________________________________________|            |
 ENDOCRINE SYSTEM                          |                                                                          |            |
                                           |__________________________________________________________________________|____________|
   Adrenal Cortex                          | +  +  +  +  +  +  +  +  +  +                                             |  10        |
      Accessory Adrenal Cortical Nodule    |          1                                                               |      1  1.0|
      Hypertrophy                          |    2  1  2  1        1  1                                                |      6  1.3|
                                           |__________________________________________________________________________|____________|
   Adrenal Medulla                         | +  +  +  +  +  +  +  +  +  +                                             |  10        |
 _____________________________________________________________________________________________________________________|____________|
  * : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade                         
  + : Tissue examined microscopically                M : Missing tissue                        1-4 : Lesion qualified as:           
  X : Lesion present but not qualified               A : Autolysis precludes examination               1) Minimal  3) Moderate      
  I : Insufficient tissue                        BLANK : Not examined                                  2) Mild     4) Marked        
                                                             Page  25                                                               
NTP Experiment-Test: 97013-92                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09  
Study Type: 26-39 WEEKS                         WATER DISINFECTION MODEL (SODIUM BROMATE)                         Date: 12/08/03    
Route: SKIN APPLICATION                                                                                           Time: 14:31:10    
 __________________________________________________________________________________________________________________________________ 
                                           | 2| 2| 2| 2| 2| 2| 0| 2| 2| 2|                                            |            |
                             DAY ON TEST   | 7| 7| 7| 7| 7| 7| 6| 2| 7| 7|                                            |            |
                                           | 2| 2| 2| 2| 2| 2| 9| 1| 2| 2|                                            |            |
 __________________________________________|__________________________________________________________________________|      T (*) |
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|                                            |      O     |
   TGAC (FVB/N) HEMIZYGOUS MALE            | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1|                                            |      T     |
                               ANIMAL ID   | 2| 2| 2| 2| 2| 2| 2| 2| 2| 2|                                            |      A     |
    256                                    | 3| 3| 3| 3| 3| 3| 3| 3| 3| 4|                                            |      L     |
    MG/KG                                  | 1| 2| 3| 4| 5| 6| 7| 8| 9| 0|                                            |            |
 _____________________________________________________________________________________________________________________|____________|
 ENDOCRINE SYSTEM - cont                   |                                                                          |            |
                                           |__________________________________________________________________________|____________|
   Pituitary Gland                         | +  +  +  +  +  +  +  +  +  +                                             |  10        |
      Pars Distalis, Cyst                  |    1  1              1                                                   |      3  1.0|
                                           |__________________________________________________________________________|____________|
   Thyroid Gland                           | +  +  +  +  +  +  +  +  +  +                                             |  10        |
      Infiltration Cellular, Lymphocyte    |       1                                                                  |      1  1.0|
      Follicle, Depletion Secretory        | 2  1  1     1  1  2  2  1  2                                             |      9  1.4|
      Follicular Cell, Hypertrophy         | 2  2  2  2  2  2     1  2                                                |      8  1.9|
 _____________________________________________________________________________________________________________________|            |
 GENERAL BODY SYSTEM                       |                                                                          |            |
    None                                   |                                                                          |            |
 _____________________________________________________________________________________________________________________|            |
 GENITAL SYSTEM                            |                                                                          |            |
                                           |__________________________________________________________________________|____________|
   Epididymis                              | +  +  +  +  +  +  +  +  +  +                                             |  10        |
      Cyst                                 |       X     X                                                            |      2     |
      Degeneration                         | 4     4     4     4     3                                                |      5  3.8|
      Inflammation, Chronic Active         |       1     2                                                            |      2  1.5|
                                           |__________________________________________________________________________|____________|
   Testes                                  | +  +  +  +  +  +  +  +  +  +                                             |  10        |
      Cyst                                 |             3     2                                                      |      2  2.5|
      Bilateral, Germinal Epithelium,      |                                                                          |            |
          Degeneration                     | 3                       3                                                |      2  3.0|
      Germinal Epithelium, Degeneration    |    3  4     4  2  3        1                                             |      6  2.8|
 _____________________________________________________________________________________________________________________|            |
 HEMATOPOIETIC SYSTEM                      |                                                                          |            |
                                           |__________________________________________________________________________|____________|
   Lymph Node, Mandibular                  | +  +  +  +  +  +  +  +  +  +                                             |  10        |
      Hyperplasia, Lymphoid                | 4           2        3                                                   |      3  3.0|
                                           |__________________________________________________________________________|____________|
   Lymph Node, Mesenteric                  | +  +  +  +  +  +  +  +  +  +                                             |  10        |
                                           |__________________________________________________________________________|____________|
   Spleen                                  | +  +  +  +  +  +  +  +  +  +                                             |  10        |
      Hematopoietic Cell Proliferation     |          2     2     1                                                   |      3  1.7|
 _____________________________________________________________________________________________________________________|____________|
  * : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade                         
  + : Tissue examined microscopically                M : Missing tissue                        1-4 : Lesion qualified as:           
  X : Lesion present but not qualified               A : Autolysis precludes examination               1) Minimal  3) Moderate      
  I : Insufficient tissue                        BLANK : Not examined                                  2) Mild     4) Marked        
                                                             Page  26                                                               
NTP Experiment-Test: 97013-92                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09  
Study Type: 26-39 WEEKS                         WATER DISINFECTION MODEL (SODIUM BROMATE)                         Date: 12/08/03    
Route: SKIN APPLICATION                                                                                           Time: 14:31:10    
 __________________________________________________________________________________________________________________________________ 
                                           | 2| 2| 2| 2| 2| 2| 0| 2| 2| 2|                                            |            |
                             DAY ON TEST   | 7| 7| 7| 7| 7| 7| 6| 2| 7| 7|                                            |            |
                                           | 2| 2| 2| 2| 2| 2| 9| 1| 2| 2|                                            |            |
 __________________________________________|__________________________________________________________________________|      T (*) |
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|                                            |      O     |
   TGAC (FVB/N) HEMIZYGOUS MALE            | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1|                                            |      T     |
                               ANIMAL ID   | 2| 2| 2| 2| 2| 2| 2| 2| 2| 2|                                            |      A     |
    256                                    | 3| 3| 3| 3| 3| 3| 3| 3| 3| 4|                                            |      L     |
    MG/KG                                  | 1| 2| 3| 4| 5| 6| 7| 8| 9| 0|                                            |            |
 _____________________________________________________________________________________________________________________|____________|
 HEMATOPOIETIC SYSTEM - cont               |                                                                          |            |
      Hyperplasia, Lymphoid                | 2                                                                        |      1  2.0|
                                           |__________________________________________________________________________|____________|
   Thymus                                  | M  +  +  +  +  +  +  +  +  +                                             |   9        |
      Atrophy                              |    3              3  1                                                   |      3  2.3|
      Cyst                                 |    1        1              1                                             |      3  1.0|
 _____________________________________________________________________________________________________________________|            |
 INTEGUMENTARY SYSTEM                      |                                                                          |            |
                                           |__________________________________________________________________________|____________|
   Mammary Gland                           | M  M  M  M  M  M  M  +  M  M                                             |   1        |
                                           |__________________________________________________________________________|____________|
   Skin                                    | +  +  +  +  +  +  +  +  +  +                                             |  10        |
      Hyperkeratosis                       |    2                                                                     |      1  2.0|
      Epidermis, Hyperplasia, Focal        |                         3  2                                             |      2  2.5|
      Site of Application - Epidermis,     |                                                                          |            |
           Hyperplasia, Focal              |                      1                                                   |      1  1.0|
 _____________________________________________________________________________________________________________________|            |
 MUSCULOSKELETAL SYSTEM                    |                                                                          |            |
    None                                   |                                                                          |            |
 _____________________________________________________________________________________________________________________|            |
 NERVOUS SYSTEM                            |                                                                          |            |
    None                                   |                                                                          |            |
 _____________________________________________________________________________________________________________________|            |
 RESPIRATORY SYSTEM                        |                                                                          |            |
                                           |__________________________________________________________________________|____________|
   Lung                                    | +  +  +  +  +  +  +  +  +  +                                             |  10        |
      Inflammation, Chronic Active         | 2                                                                        |      1  2.0|
 _____________________________________________________________________________________________________________________|            |
 SPECIAL SENSES SYSTEM                     |                                                                          |            |
    None                                   |                                                                          |            |
 _____________________________________________________________________________________________________________________|            |
 URINARY SYSTEM                            |                                                                          |            |
                                           |__________________________________________________________________________|____________|
   Kidney                                  | +  +  +  +  +  +  +  +  +  +                                             |  10        |
      Nephropathy                          | 2  1  1  1  1  2  1  1  1  1                                             |     10  1.2|
 _____________________________________________________________________________________________________________________|____________|
  * : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade                         
  + : Tissue examined microscopically                M : Missing tissue                        1-4 : Lesion qualified as:           
  X : Lesion present but not qualified               A : Autolysis precludes examination               1) Minimal  3) Moderate      
  I : Insufficient tissue                        BLANK : Not examined                                  2) Mild     4) Marked        
                                                             Page  27                                                               
NTP Experiment-Test: 97013-92                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09  
Study Type: 26-39 WEEKS                         WATER DISINFECTION MODEL (SODIUM BROMATE)                         Date: 12/08/03    
Route: SKIN APPLICATION                                                                                           Time: 14:31:10    
 __________________________________________________________________________________________________________________________________ 
                                           | 2| 2| 2| 2| 2| 2| 0| 2| 2| 2|                                            |            |
                             DAY ON TEST   | 7| 7| 7| 7| 7| 7| 6| 2| 7| 7|                                            |            |
                                           | 2| 2| 2| 2| 2| 2| 9| 1| 2| 2|                                            |            |
 __________________________________________|__________________________________________________________________________|      T (*) |
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|                                            |      O     |
   TGAC (FVB/N) HEMIZYGOUS MALE            | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1|                                            |      T     |
                               ANIMAL ID   | 2| 2| 2| 2| 2| 2| 2| 2| 2| 2|                                            |      A     |
    256                                    | 3| 3| 3| 3| 3| 3| 3| 3| 3| 4|                                            |      L     |
    MG/KG                                  | 1| 2| 3| 4| 5| 6| 7| 8| 9| 0|                                            |            |
 _____________________________________________________________________________________________________________________|____________|
 URINARY SYSTEM - cont                     |                                                                          |            |
      Glomerulus, Inflammation,            |                                                                          |            |
          Membranoproliferative            |                   1                                                      |      1  1.0|
      Pelvis, Dilatation                   | 1                                                                        |      1  1.0|
      Renal Tubule, Hypertrophy            |             1  1                                                         |      2  1.0|
 __________________________________________________________________________________________________________________________________ 
  * : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade                         
  + : Tissue examined microscopically                M : Missing tissue                        1-4 : Lesion qualified as:           
  X : Lesion present but not qualified               A : Autolysis precludes examination               1) Minimal  3) Moderate      
  I : Insufficient tissue                        BLANK : Not examined                                  2) Mild     4) Marked        
                                                             Page  28                                                               
                             ------------------------------------------------------------                                           
                             ----------              END OF REPORT             ----------                                           
                             ------------------------------------------------------------