TDMS Study 97013-93 Pathology Tables
NTP Experiment-Test: 97013-93 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09 Study Type: 26-39 WEEKS WATER DISINFECTION MODEL (SODIUM BROMATE) Date: 12/08/03 Route: DOSED WATER Time: 14:36:57 FINAL#1 MICE Facility: Battelle Columbus Laboratory Chemical CAS #: 7789-38-0 Lock Date: 07/30/01 Cage Range: All Reasons For Removal: All Removal Date Range: All Treatment Groups: Include All Page 1 NTP Experiment-Test: 97013-93 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09 Study Type: 26-39 WEEKS WATER DISINFECTION MODEL (SODIUM BROMATE) Date: 12/08/03 Route: DOSED WATER Time: 14:36:57 __________________________________________________________________________________________________________________________________ | 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| | | DAY ON TEST | 9| 9| 9| 9| 9| 9| 9| 9| 8| 9| | | | 5| 5| 5| 5| 5| 5| 5| 5| 2| 5| | | __________________________________________|__________________________________________________________________________| T (*) | | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | O | P53+/-(C57BL/6) FEMALE | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| | T | ANIMAL ID | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| | A | 0 MG/L | 4| 4| 4| 4| 4| 4| 4| 4| 4| 5| | L | | 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| | | _____________________________________________________________________________________________________________________|____________| ALIMENTARY SYSTEM | | | |__________________________________________________________________________|____________| Intestine Large, Colon | + + + + + + + + + + | 10 | |__________________________________________________________________________|____________| Intestine Large, Cecum | + + + + + + + + + + | 10 | |__________________________________________________________________________|____________| Intestine Small, Duodenum | + + + + + + + + + + | 10 | |__________________________________________________________________________|____________| Intestine Small, Jejunum | + + + + + + + + + + | 10 | |__________________________________________________________________________|____________| Intestine Small, Ileum | + + + + + + + + + + | 10 | |__________________________________________________________________________|____________| Liver | + + + + + + + + + + | 10 | Inflammation, Chronic Active | 1 2 1 1 1 1 1 1 1 | 9 1.1| Hepatocyte, Fatty Change | 1 | 1 1.0| Hepatocyte, Vacuolization Cytoplasmic| 1 1 1 1 1 1 2 1 1 | 9 1.1| |__________________________________________________________________________|____________| Stomach, Forestomach | + + + + + + + + + + | 10 | Inflammation, Chronic Active | 2 | 1 2.0| Epithelium, Hyperkeratosis | 1 3 | 2 2.0| Epithelium, Hyperplasia | 2 3 | 2 2.5| Epithelium, Ulcer | 2 | 1 2.0| _____________________________________________________________________________________________________________________| | CARDIOVASCULAR SYSTEM | | | None | | | _____________________________________________________________________________________________________________________| | ENDOCRINE SYSTEM | | | |__________________________________________________________________________|____________| Adrenal Cortex | + + + + + + + + + + | 10 | Accessory Adrenal Cortical Nodule | 2 | 1 2.0| Infiltration Cellular, Lymphocyte | 1 | 1 1.0| Subcapsular, Hyperplasia | 1 1 2 1 1 1 1 1 | 8 1.1| |__________________________________________________________________________|____________| Adrenal Medulla | + + + + + + + + + + | 10 | |__________________________________________________________________________|____________| _____________________________________________________________________________________________________________________|____________| * : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade + : Tissue examined microscopically M : Missing tissue 1-4 : Lesion qualified as: X : Lesion present but not qualified A : Autolysis precludes examination 1) Minimal 3) Moderate I : Insufficient tissue BLANK : Not examined 2) Mild 4) Marked Page 2 NTP Experiment-Test: 97013-93 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09 Study Type: 26-39 WEEKS WATER DISINFECTION MODEL (SODIUM BROMATE) Date: 12/08/03 Route: DOSED WATER Time: 14:36:57 __________________________________________________________________________________________________________________________________ | 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| | | DAY ON TEST | 9| 9| 9| 9| 9| 9| 9| 9| 8| 9| | | | 5| 5| 5| 5| 5| 5| 5| 5| 2| 5| | | __________________________________________|__________________________________________________________________________| T (*) | | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | O | P53+/-(C57BL/6) FEMALE | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| | T | ANIMAL ID | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| | A | 0 MG/L | 4| 4| 4| 4| 4| 4| 4| 4| 4| 5| | L | | 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| | | _____________________________________________________________________________________________________________________|____________| ENDOCRINE SYSTEM - cont | | | Pituitary Gland | + + + + + + + + + + | 10 | |__________________________________________________________________________|____________| Thyroid Gland | + + + + + + + + + + | 10 | Ectopic Thymus | 1 | 1 1.0| Infiltration Cellular, Lymphocyte | 1 1 | 2 1.0| _____________________________________________________________________________________________________________________| | GENERAL BODY SYSTEM | | | None | | | _____________________________________________________________________________________________________________________| | GENITAL SYSTEM | | | |__________________________________________________________________________|____________| Ovary | + + + + + + + + + + | 10 | Cyst | 2 3 2 | 3 2.3| |__________________________________________________________________________|____________| Uterus | + + + + + + + + + + | 10 | Inflammation, Suppurative | 2 | 1 2.0| Endometrium, Hyperplasia, Cystic | 1 2 2 2 2 2 2 1 2 | 9 1.8| _____________________________________________________________________________________________________________________| | HEMATOPOIETIC SYSTEM | | | |__________________________________________________________________________|____________| Lymph Node | + | 1 | |__________________________________________________________________________|____________| Lymph Node, Mandibular | + + + + + + + + + + | 10 | Hyperplasia, Lymphoid | 3 | 1 3.0| |__________________________________________________________________________|____________| Lymph Node, Mesenteric | + + + + + + + + + + | 10 | |__________________________________________________________________________|____________| Spleen | + + + + + + + + + + | 10 | |__________________________________________________________________________|____________| Thymus | + + + + + + + + + + | 10 | Cyst | 1 1 | 2 1.0| _____________________________________________________________________________________________________________________| | INTEGUMENTARY SYSTEM | | | None | | | _____________________________________________________________________________________________________________________|____________| * : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade + : Tissue examined microscopically M : Missing tissue 1-4 : Lesion qualified as: X : Lesion present but not qualified A : Autolysis precludes examination 1) Minimal 3) Moderate I : Insufficient tissue BLANK : Not examined 2) Mild 4) Marked Page 3 NTP Experiment-Test: 97013-93 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09 Study Type: 26-39 WEEKS WATER DISINFECTION MODEL (SODIUM BROMATE) Date: 12/08/03 Route: DOSED WATER Time: 14:36:57 __________________________________________________________________________________________________________________________________ | 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| | | DAY ON TEST | 9| 9| 9| 9| 9| 9| 9| 9| 8| 9| | | | 5| 5| 5| 5| 5| 5| 5| 5| 2| 5| | | __________________________________________|__________________________________________________________________________| T (*) | | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | O | P53+/-(C57BL/6) FEMALE | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| | T | ANIMAL ID | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| | A | 0 MG/L | 4| 4| 4| 4| 4| 4| 4| 4| 4| 5| | L | | 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| | | _____________________________________________________________________________________________________________________|____________| MUSCULOSKELETAL SYSTEM | | | None | | | _____________________________________________________________________________________________________________________| | NERVOUS SYSTEM | | | None | | | _____________________________________________________________________________________________________________________| | RESPIRATORY SYSTEM | | | |__________________________________________________________________________|____________| Lung | + + + + + + + + + + | 10 | Perivascular, Infiltration Cellular, | | | Lymphocyte | 2 2 2 2 | 4 2.0| _____________________________________________________________________________________________________________________| | SPECIAL SENSES SYSTEM | | | None | | | _____________________________________________________________________________________________________________________| | URINARY SYSTEM | | | |__________________________________________________________________________|____________| Kidney | + + + + + + + + + + | 10 | Nephropathy | 1 1 1 1 1 1 2 | 7 1.1| __________________________________________________________________________________________________________________________________ * : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade + : Tissue examined microscopically M : Missing tissue 1-4 : Lesion qualified as: X : Lesion present but not qualified A : Autolysis precludes examination 1) Minimal 3) Moderate I : Insufficient tissue BLANK : Not examined 2) Mild 4) Marked Page 4 NTP Experiment-Test: 97013-93 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09 Study Type: 26-39 WEEKS WATER DISINFECTION MODEL (SODIUM BROMATE) Date: 12/08/03 Route: DOSED WATER Time: 14:36:57 __________________________________________________________________________________________________________________________________ | 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| | | DAY ON TEST | 9| 9| 7| 9| 9| 9| 9| 9| 9| 9| | | | 5| 5| 6| 5| 5| 5| 5| 5| 5| 5| | | __________________________________________|__________________________________________________________________________| T (*) | | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | O | P53+/-(C57BL/6) FEMALE | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| | T | ANIMAL ID | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| | A | 80 MG/L | 5| 5| 5| 5| 5| 5| 5| 5| 5| 6| | L | | 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| | | _____________________________________________________________________________________________________________________|____________| ALIMENTARY SYSTEM | | | |__________________________________________________________________________|____________| Intestine Large, Colon | + + + + + + + + + + | 10 | |__________________________________________________________________________|____________| Intestine Large, Cecum | + + + + + + + + + + | 10 | |__________________________________________________________________________|____________| Intestine Small, Duodenum | + + + + + + + + + + | 10 | |__________________________________________________________________________|____________| Intestine Small, Jejunum | + + + + + + + + + + | 10 | |__________________________________________________________________________|____________| Intestine Small, Ileum | + + + + + + + + + + | 10 | |__________________________________________________________________________|____________| Liver | + + + + + + + + + + | 10 | Hematopoietic Cell Proliferation | 2 | 1 2.0| Inflammation, Chronic Active | 1 1 1 1 1 1 1 1 1 1 | 10 1.0| Hepatocyte, Fatty Change | 1 | 1 1.0| Hepatocyte, Vacuolization Cytoplasmic| 1 1 1 2 1 1 2 1 1 1 | 10 1.2| |__________________________________________________________________________|____________| Pancreas | + | 1 | |__________________________________________________________________________|____________| Stomach, Forestomach | + + + + + + + + + + | 10 | Epithelium, Hyperkeratosis | 1 | 1 1.0| Epithelium, Hyperplasia | 2 | 1 2.0| _____________________________________________________________________________________________________________________| | CARDIOVASCULAR SYSTEM | | | None | | | _____________________________________________________________________________________________________________________| | ENDOCRINE SYSTEM | | | |__________________________________________________________________________|____________| Adrenal Cortex | + + + + + + + + + + | 10 | Accessory Adrenal Cortical Nodule | 2 | 1 2.0| Subcapsular, Hyperplasia | 1 1 1 1 1 1 1 1 1 | 9 1.0| |__________________________________________________________________________|____________| Adrenal Medulla | + + + + + + + + + + | 10 | |__________________________________________________________________________|____________| _____________________________________________________________________________________________________________________|____________| * : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade + : Tissue examined microscopically M : Missing tissue 1-4 : Lesion qualified as: X : Lesion present but not qualified A : Autolysis precludes examination 1) Minimal 3) Moderate I : Insufficient tissue BLANK : Not examined 2) Mild 4) Marked Page 5 NTP Experiment-Test: 97013-93 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09 Study Type: 26-39 WEEKS WATER DISINFECTION MODEL (SODIUM BROMATE) Date: 12/08/03 Route: DOSED WATER Time: 14:36:57 __________________________________________________________________________________________________________________________________ | 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| | | DAY ON TEST | 9| 9| 7| 9| 9| 9| 9| 9| 9| 9| | | | 5| 5| 6| 5| 5| 5| 5| 5| 5| 5| | | __________________________________________|__________________________________________________________________________| T (*) | | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | O | P53+/-(C57BL/6) FEMALE | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| | T | ANIMAL ID | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| | A | 80 MG/L | 5| 5| 5| 5| 5| 5| 5| 5| 5| 6| | L | | 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| | | _____________________________________________________________________________________________________________________|____________| ENDOCRINE SYSTEM - cont | | | Pituitary Gland | + + + + + + + + + + | 10 | Pars Distalis, Hyperplasia | 1 | 1 1.0| |__________________________________________________________________________|____________| Thyroid Gland | + + + + + + + + + + | 10 | _____________________________________________________________________________________________________________________| | GENERAL BODY SYSTEM | | | None | | | _____________________________________________________________________________________________________________________| | GENITAL SYSTEM | | | |__________________________________________________________________________|____________| Ovary | + + + + + + + + + + | 10 | Cyst | 3 3 | 2 3.0| Bilateral, Cyst | 3 | 1 3.0| |__________________________________________________________________________|____________| Uterus | + + + + + + + + + + | 10 | Endometrium, Hyperplasia, Cystic | 1 2 2 2 2 1 2 1 2 2 | 10 1.7| _____________________________________________________________________________________________________________________| | HEMATOPOIETIC SYSTEM | | | |__________________________________________________________________________|____________| Lymph Node, Mandibular | + + + + + + + + + + | 10 | Hyperplasia, Lymphoid | 2 | 1 2.0| |__________________________________________________________________________|____________| Lymph Node, Mesenteric | + + + + + + + + + + | 10 | |__________________________________________________________________________|____________| Spleen | + + + + + + + + + + | 10 | Hematopoietic Cell Proliferation | 3 | 1 3.0| |__________________________________________________________________________|____________| Thymus | + + + + + + + + + + | 10 | Cyst | 1 1 1 1 | 4 1.0| _____________________________________________________________________________________________________________________| | INTEGUMENTARY SYSTEM | | | |__________________________________________________________________________|____________| Skin | + | 1 | Inflammation, Chronic Active | 3 | 1 3.0| _____________________________________________________________________________________________________________________| | MUSCULOSKELETAL SYSTEM | | | None | | | _____________________________________________________________________________________________________________________|____________| * : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade + : Tissue examined microscopically M : Missing tissue 1-4 : Lesion qualified as: X : Lesion present but not qualified A : Autolysis precludes examination 1) Minimal 3) Moderate I : Insufficient tissue BLANK : Not examined 2) Mild 4) Marked Page 6 NTP Experiment-Test: 97013-93 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09 Study Type: 26-39 WEEKS WATER DISINFECTION MODEL (SODIUM BROMATE) Date: 12/08/03 Route: DOSED WATER Time: 14:36:57 __________________________________________________________________________________________________________________________________ | 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| | | DAY ON TEST | 9| 9| 7| 9| 9| 9| 9| 9| 9| 9| | | | 5| 5| 6| 5| 5| 5| 5| 5| 5| 5| | | __________________________________________|__________________________________________________________________________| T (*) | | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | O | P53+/-(C57BL/6) FEMALE | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| | T | ANIMAL ID | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| | A | 80 MG/L | 5| 5| 5| 5| 5| 5| 5| 5| 5| 6| | L | | 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| | | _____________________________________________________________________________________________________________________|____________| NERVOUS SYSTEM | | | |__________________________________________________________________________|____________| Peripheral Nerve | + | 1 | |__________________________________________________________________________|____________| Spinal Cord | + | 1 | _____________________________________________________________________________________________________________________| | RESPIRATORY SYSTEM | | | |__________________________________________________________________________|____________| Lung | + + + + + + + + + + | 10 | Perivascular, Infiltration Cellular, | | | Lymphocyte | 2 2 1 | 3 1.7| _____________________________________________________________________________________________________________________| | SPECIAL SENSES SYSTEM | | | None | | | _____________________________________________________________________________________________________________________| | URINARY SYSTEM | | | |__________________________________________________________________________|____________| Kidney | + + + + + + + + + + | 10 | Mineralization | 1 | 1 1.0| Nephropathy | 1 1 1 1 1 1 1 | 7 1.0| Papilla, Mineralization | 1 | 1 1.0| __________________________________________________________________________________________________________________________________ * : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade + : Tissue examined microscopically M : Missing tissue 1-4 : Lesion qualified as: X : Lesion present but not qualified A : Autolysis precludes examination 1) Minimal 3) Moderate I : Insufficient tissue BLANK : Not examined 2) Mild 4) Marked Page 7 NTP Experiment-Test: 97013-93 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09 Study Type: 26-39 WEEKS WATER DISINFECTION MODEL (SODIUM BROMATE) Date: 12/08/03 Route: DOSED WATER Time: 14:36:57 __________________________________________________________________________________________________________________________________ | 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| | | DAY ON TEST | 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| | | | 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| | | __________________________________________|__________________________________________________________________________| T (*) | | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | O | P53+/-(C57BL/6) FEMALE | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| | T | ANIMAL ID | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| | A | 400 MG/L | 6| 6| 6| 6| 6| 6| 6| 6| 6| 7| | L | | 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| | | _____________________________________________________________________________________________________________________|____________| ALIMENTARY SYSTEM | | | |__________________________________________________________________________|____________| Intestine Large, Colon | + + + + + + + + + + | 10 | |__________________________________________________________________________|____________| Intestine Large, Cecum | + + + + + + + + + + | 10 | |__________________________________________________________________________|____________| Intestine Small, Duodenum | + + + + + + + + + + | 10 | |__________________________________________________________________________|____________| Intestine Small, Jejunum | + + + + + + + + + + | 10 | |__________________________________________________________________________|____________| Intestine Small, Ileum | + + + + + + + + + + | 10 | |__________________________________________________________________________|____________| Liver | + + + + + + + + + + | 10 | Inflammation, Chronic Active | 1 1 1 1 1 1 1 1 | 8 1.0| Hepatocyte, Vacuolization Cytoplasmic| 1 1 2 1 2 1 2 1 | 8 1.4| |__________________________________________________________________________|____________| Oral Mucosa | + | 1 | |__________________________________________________________________________|____________| Stomach, Forestomach | + + + + + + + + + + | 10 | _____________________________________________________________________________________________________________________| | CARDIOVASCULAR SYSTEM | | | None | | | _____________________________________________________________________________________________________________________| | ENDOCRINE SYSTEM | | | |__________________________________________________________________________|____________| Adrenal Cortex | + + + + + + + + + + | 10 | Subcapsular, Hyperplasia | 1 1 1 1 1 1 2 1 1 1 | 10 1.1| |__________________________________________________________________________|____________| Adrenal Medulla | + + + + + + + + + + | 10 | |__________________________________________________________________________|____________| Pituitary Gland | + + + + + + + + + + | 10 | Pars Distalis, Cyst | 1 1 | 2 1.0| Pars Distalis, Hyperplasia | 2 2 | 2 2.0| |__________________________________________________________________________|____________| Thyroid Gland | + + + + + + + + + + | 10 | _____________________________________________________________________________________________________________________|____________| * : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade + : Tissue examined microscopically M : Missing tissue 1-4 : Lesion qualified as: X : Lesion present but not qualified A : Autolysis precludes examination 1) Minimal 3) Moderate I : Insufficient tissue BLANK : Not examined 2) Mild 4) Marked Page 8 NTP Experiment-Test: 97013-93 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09 Study Type: 26-39 WEEKS WATER DISINFECTION MODEL (SODIUM BROMATE) Date: 12/08/03 Route: DOSED WATER Time: 14:36:57 __________________________________________________________________________________________________________________________________ | 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| | | DAY ON TEST | 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| | | | 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| | | __________________________________________|__________________________________________________________________________| T (*) | | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | O | P53+/-(C57BL/6) FEMALE | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| | T | ANIMAL ID | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| | A | 400 MG/L | 6| 6| 6| 6| 6| 6| 6| 6| 6| 7| | L | | 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| | | _____________________________________________________________________________________________________________________|____________| ENDOCRINE SYSTEM - cont | | | Infiltration Cellular, Lymphocyte | 1 | 1 1.0| _____________________________________________________________________________________________________________________| | GENERAL BODY SYSTEM | | | None | | | _____________________________________________________________________________________________________________________| | GENITAL SYSTEM | | | |__________________________________________________________________________|____________| Ovary | + + + + + + + + + + | 10 | Atrophy | 3 | 1 3.0| Cyst | 2 | 1 2.0| |__________________________________________________________________________|____________| Uterus | + + + + + + + + + + | 10 | Endometrium, Hyperplasia, Cystic | 1 2 1 2 2 2 2 1 | 8 1.6| _____________________________________________________________________________________________________________________| | HEMATOPOIETIC SYSTEM | | | |__________________________________________________________________________|____________| Lymph Node | + | 1 | |__________________________________________________________________________|____________| Lymph Node, Mandibular | + + + + + + + + + + | 10 | Hyperplasia, Lymphoid | 2 | 1 2.0| |__________________________________________________________________________|____________| Lymph Node, Mesenteric | + + + + + + + + + + | 10 | Hyperplasia, Lymphoid | 3 | 1 3.0| |__________________________________________________________________________|____________| Spleen | + + + + + + + + + + | 10 | Hematopoietic Cell Proliferation | 3 | 1 3.0| Hyperplasia, Lymphoid | 3 | 1 3.0| |__________________________________________________________________________|____________| Thymus | + + + + + + + + + + | 10 | Cyst | 1 1 1 2 1 | 5 1.2| Ectopic Parathyroid Gland | 1 | 1 1.0| _____________________________________________________________________________________________________________________| | INTEGUMENTARY SYSTEM | | | |__________________________________________________________________________|____________| _____________________________________________________________________________________________________________________|____________| * : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade + : Tissue examined microscopically M : Missing tissue 1-4 : Lesion qualified as: X : Lesion present but not qualified A : Autolysis precludes examination 1) Minimal 3) Moderate I : Insufficient tissue BLANK : Not examined 2) Mild 4) Marked Page 9 NTP Experiment-Test: 97013-93 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09 Study Type: 26-39 WEEKS WATER DISINFECTION MODEL (SODIUM BROMATE) Date: 12/08/03 Route: DOSED WATER Time: 14:36:57 __________________________________________________________________________________________________________________________________ | 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| | | DAY ON TEST | 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| | | | 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| | | __________________________________________|__________________________________________________________________________| T (*) | | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | O | P53+/-(C57BL/6) FEMALE | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| | T | ANIMAL ID | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| | A | 400 MG/L | 6| 6| 6| 6| 6| 6| 6| 6| 6| 7| | L | | 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| | | _____________________________________________________________________________________________________________________|____________| INTEGUMENTARY SYSTEM - cont | | | Skin | + | 1 | Hyperkeratosis | 2 | 1 2.0| Hyperplasia | 3 | 1 3.0| Inflammation, Chronic Active | 4 | 1 4.0| Ulcer | 4 | 1 4.0| _____________________________________________________________________________________________________________________| | MUSCULOSKELETAL SYSTEM | | | None | | | _____________________________________________________________________________________________________________________| | NERVOUS SYSTEM | | | None | | | _____________________________________________________________________________________________________________________| | RESPIRATORY SYSTEM | | | |__________________________________________________________________________|____________| Lung | + + + + + + + + + + | 10 | Perivascular, Infiltration Cellular, | | | Lymphocyte | 2 3 2 2 | 4 2.3| _____________________________________________________________________________________________________________________| | SPECIAL SENSES SYSTEM | | | None | | | _____________________________________________________________________________________________________________________| | URINARY SYSTEM | | | |__________________________________________________________________________|____________| Kidney | + + + + + + + + + + | 10 | Nephropathy | 1 1 1 1 1 1 | 6 1.0| __________________________________________________________________________________________________________________________________ * : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade + : Tissue examined microscopically M : Missing tissue 1-4 : Lesion qualified as: X : Lesion present but not qualified A : Autolysis precludes examination 1) Minimal 3) Moderate I : Insufficient tissue BLANK : Not examined 2) Mild 4) Marked Page 10 NTP Experiment-Test: 97013-93 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09 Study Type: 26-39 WEEKS WATER DISINFECTION MODEL (SODIUM BROMATE) Date: 12/08/03 Route: DOSED WATER Time: 14:36:57 __________________________________________________________________________________________________________________________________ | 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| | | DAY ON TEST | 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| | | | 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| | | __________________________________________|__________________________________________________________________________| T (*) | | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | O | P53+/-(C57BL/6) FEMALE | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| | T | ANIMAL ID | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| | A | 800 MG/L | 7| 7| 7| 7| 7| 7| 7| 7| 7| 8| | L | | 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| | | _____________________________________________________________________________________________________________________|____________| ALIMENTARY SYSTEM | | | |__________________________________________________________________________|____________| Intestine Large, Colon | + + + + + + + + + + | 10 | |__________________________________________________________________________|____________| Intestine Large, Cecum | + + + + + + + + + + | 10 | |__________________________________________________________________________|____________| Intestine Small, Duodenum | + + + + + + + + + + | 10 | |__________________________________________________________________________|____________| Intestine Small, Jejunum | + + + + + + + + + + | 10 | |__________________________________________________________________________|____________| Intestine Small, Ileum | + + + + + + + + + + | 10 | |__________________________________________________________________________|____________| Liver | + + + + + + + + + + | 10 | Angiectasis | 1 2 | 2 1.5| Inflammation, Chronic Active | 1 1 1 1 2 1 1 1 1 1 | 10 1.1| Mixed Cell Focus | X | 1 | Hepatocyte, Vacuolization Cytoplasmic| 1 1 2 1 1 1 2 1 1 1 | 10 1.2| |__________________________________________________________________________|____________| Stomach, Forestomach | + + + + + + + + + + | 10 | Epithelium, Hyperkeratosis | 1 | 1 1.0| Epithelium, Hyperplasia | 2 2 2 | 3 2.0| _____________________________________________________________________________________________________________________| | CARDIOVASCULAR SYSTEM | | | None | | | _____________________________________________________________________________________________________________________| | ENDOCRINE SYSTEM | | | |__________________________________________________________________________|____________| Adrenal Cortex | + + + + + + + + + + | 10 | Infiltration Cellular, Lymphocyte | 1 | 1 1.0| Subcapsular, Hyperplasia | 1 1 1 1 1 1 1 1 1 2 | 10 1.1| |__________________________________________________________________________|____________| Adrenal Medulla | + + + + + + + + + + | 10 | |__________________________________________________________________________|____________| Pituitary Gland | + + + + + + + + + + | 10 | Pars Distalis, Cyst | 1 | 1 1.0| _____________________________________________________________________________________________________________________|____________| * : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade + : Tissue examined microscopically M : Missing tissue 1-4 : Lesion qualified as: X : Lesion present but not qualified A : Autolysis precludes examination 1) Minimal 3) Moderate I : Insufficient tissue BLANK : Not examined 2) Mild 4) Marked Page 11 NTP Experiment-Test: 97013-93 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09 Study Type: 26-39 WEEKS WATER DISINFECTION MODEL (SODIUM BROMATE) Date: 12/08/03 Route: DOSED WATER Time: 14:36:57 __________________________________________________________________________________________________________________________________ | 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| | | DAY ON TEST | 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| | | | 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| | | __________________________________________|__________________________________________________________________________| T (*) | | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | O | P53+/-(C57BL/6) FEMALE | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| | T | ANIMAL ID | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| | A | 800 MG/L | 7| 7| 7| 7| 7| 7| 7| 7| 7| 8| | L | | 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| | | _____________________________________________________________________________________________________________________|____________| ENDOCRINE SYSTEM - cont | | | |__________________________________________________________________________|____________| Thyroid Gland | + + + + + + + + + + | 10 | Infiltration Cellular, Lymphocyte | 1 | 1 1.0| Follicle, Cyst | 2 2 | 2 2.0| _____________________________________________________________________________________________________________________| | GENERAL BODY SYSTEM | | | None | | | _____________________________________________________________________________________________________________________| | GENITAL SYSTEM | | | |__________________________________________________________________________|____________| Ovary | + + + + + + + + + + | 10 | Cyst | 3 2 | 2 2.5| |__________________________________________________________________________|____________| Uterus | + + + + + + + + + + | 10 | Endometrium, Hyperplasia, Cystic | 1 2 1 2 3 2 2 1 | 8 1.8| _____________________________________________________________________________________________________________________| | HEMATOPOIETIC SYSTEM | | | |__________________________________________________________________________|____________| Lymph Node, Mandibular | + + + + + + + + + + | 10 | Hyperplasia, Lymphoid | 2 2 | 2 2.0| |__________________________________________________________________________|____________| Lymph Node, Mesenteric | + + + + + + + + + + | 10 | |__________________________________________________________________________|____________| Spleen | + + + + + + + + + + | 10 | |__________________________________________________________________________|____________| Thymus | + + + + + + + + + + | 10 | Cyst | 2 1 2 | 3 1.7| Ectopic Parathyroid Gland | 1 | 1 1.0| Ectopic Thyroid | 1 | 1 1.0| _____________________________________________________________________________________________________________________| | INTEGUMENTARY SYSTEM | | | |__________________________________________________________________________|____________| Skin | + | 1 | _____________________________________________________________________________________________________________________| | MUSCULOSKELETAL SYSTEM | | | None | | | _____________________________________________________________________________________________________________________|____________| * : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade + : Tissue examined microscopically M : Missing tissue 1-4 : Lesion qualified as: X : Lesion present but not qualified A : Autolysis precludes examination 1) Minimal 3) Moderate I : Insufficient tissue BLANK : Not examined 2) Mild 4) Marked Page 12 NTP Experiment-Test: 97013-93 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09 Study Type: 26-39 WEEKS WATER DISINFECTION MODEL (SODIUM BROMATE) Date: 12/08/03 Route: DOSED WATER Time: 14:36:57 __________________________________________________________________________________________________________________________________ | 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| | | DAY ON TEST | 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| | | | 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| | | __________________________________________|__________________________________________________________________________| T (*) | | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | O | P53+/-(C57BL/6) FEMALE | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| | T | ANIMAL ID | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| | A | 800 MG/L | 7| 7| 7| 7| 7| 7| 7| 7| 7| 8| | L | | 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| | | _____________________________________________________________________________________________________________________|____________| NERVOUS SYSTEM | | | None | | | _____________________________________________________________________________________________________________________| | RESPIRATORY SYSTEM | | | |__________________________________________________________________________|____________| Lung | + + + + + M + + + + | 9 | Alveolar Epithelium, Hyperplasia | 2 | 1 2.0| Perivascular, Infiltration Cellular, | | | Lymphocyte | 2 2 | 2 2.0| _____________________________________________________________________________________________________________________| | SPECIAL SENSES SYSTEM | | | None | | | _____________________________________________________________________________________________________________________| | URINARY SYSTEM | | | |__________________________________________________________________________|____________| Kidney | + + + + + + + + + + | 10 | Mineralization | 1 | 1 1.0| Nephropathy | 1 1 1 1 1 1 1 1 | 8 1.0| __________________________________________________________________________________________________________________________________ * : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade + : Tissue examined microscopically M : Missing tissue 1-4 : Lesion qualified as: X : Lesion present but not qualified A : Autolysis precludes examination 1) Minimal 3) Moderate I : Insufficient tissue BLANK : Not examined 2) Mild 4) Marked Page 13 NTP Experiment-Test: 97013-93 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09 Study Type: 26-39 WEEKS WATER DISINFECTION MODEL (SODIUM BROMATE) Date: 12/08/03 Route: DOSED WATER Time: 14:36:57 __________________________________________________________________________________________________________________________________ | 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| | | DAY ON TEST | 9| 9| 9| 9| 9| 9| 9| 9| 7| 9| | | | 5| 5| 5| 5| 5| 5| 5| 5| 6| 5| | | __________________________________________|__________________________________________________________________________| T (*) | | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | O | P53+/-(C57BL/6) MALE | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| | T | ANIMAL ID | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| | A | 0 MG/L | 0| 0| 0| 0| 0| 0| 0| 0| 0| 1| | L | | 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| | | _____________________________________________________________________________________________________________________|____________| ALIMENTARY SYSTEM | | | |__________________________________________________________________________|____________| Gallbladder | + | 1 | |__________________________________________________________________________|____________| Intestine Large, Colon | + + + + + + + + + + | 10 | |__________________________________________________________________________|____________| Intestine Large, Cecum | + + + + + + + + + + | 10 | |__________________________________________________________________________|____________| Intestine Small, Duodenum | + + + + + + + + + + | 10 | |__________________________________________________________________________|____________| Intestine Small, Jejunum | + + + + + + + + + + | 10 | |__________________________________________________________________________|____________| Intestine Small, Ileum | + + + + + + + + + + | 10 | |__________________________________________________________________________|____________| Liver | + + + + + + + + + + | 10 | Inflammation, Chronic Active | 1 1 1 1 1 1 1 1 1 | 9 1.0| Hepatocyte, Fatty Change | 1 1 2 3 2 3 1 | 7 1.9| Hepatocyte, Necrosis | 1 | 1 1.0| Hepatocyte, Vacuolization Cytoplasmic| 3 2 3 3 3 4 2 3 4 | 9 3.0| |__________________________________________________________________________|____________| Mesentery | + | 1 | |__________________________________________________________________________|____________| Stomach, Forestomach | + + + + + + + + + + | 10 | Inflammation, Chronic Active | 2 | 1 2.0| Epithelium, Hyperkeratosis | 2 | 1 2.0| Epithelium, Hyperplasia | 1 3 | 2 2.0| Epithelium, Ulcer | 2 | 1 2.0| _____________________________________________________________________________________________________________________| | CARDIOVASCULAR SYSTEM | | | |__________________________________________________________________________|____________| Blood Vessel | + | 1 | _____________________________________________________________________________________________________________________| | ENDOCRINE SYSTEM | | | |__________________________________________________________________________|____________| Adrenal Cortex | + + + + + + + + + + | 10 | _____________________________________________________________________________________________________________________|____________| * : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade + : Tissue examined microscopically M : Missing tissue 1-4 : Lesion qualified as: X : Lesion present but not qualified A : Autolysis precludes examination 1) Minimal 3) Moderate I : Insufficient tissue BLANK : Not examined 2) Mild 4) Marked Page 14 NTP Experiment-Test: 97013-93 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09 Study Type: 26-39 WEEKS WATER DISINFECTION MODEL (SODIUM BROMATE) Date: 12/08/03 Route: DOSED WATER Time: 14:36:57 __________________________________________________________________________________________________________________________________ | 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| | | DAY ON TEST | 9| 9| 9| 9| 9| 9| 9| 9| 7| 9| | | | 5| 5| 5| 5| 5| 5| 5| 5| 6| 5| | | __________________________________________|__________________________________________________________________________| T (*) | | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | O | P53+/-(C57BL/6) MALE | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| | T | ANIMAL ID | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| | A | 0 MG/L | 0| 0| 0| 0| 0| 0| 0| 0| 0| 1| | L | | 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| | | _____________________________________________________________________________________________________________________|____________| ENDOCRINE SYSTEM - cont | | | Hypertrophy | 1 | 1 1.0| Subcapsular, Hyperplasia | 1 1 1 | 3 1.0| |__________________________________________________________________________|____________| Adrenal Medulla | + + + + + + + + + + | 10 | |__________________________________________________________________________|____________| Pituitary Gland | + + + + + + + + + + | 10 | Pars Distalis, Cyst | 1 1 1 | 3 1.0| |__________________________________________________________________________|____________| Thyroid Gland | + + + + + + + + + + | 10 | Infiltration Cellular, Lymphocyte | 1 | 1 1.0| _____________________________________________________________________________________________________________________| | GENERAL BODY SYSTEM | | | None | | | _____________________________________________________________________________________________________________________| | GENITAL SYSTEM | | | |__________________________________________________________________________|____________| Epididymis | + + + + + + + + + + | 10 | Atrophy | 4 | 1 4.0| |__________________________________________________________________________|____________| Testes | + + + + + + + + + + | 10 | Germinal Epithelium, Degeneration | 1 1 | 2 1.0| Germinal Epithelium, Necrosis | 4 | 1 4.0| _____________________________________________________________________________________________________________________| | HEMATOPOIETIC SYSTEM | | | |__________________________________________________________________________|____________| Lymph Node | + | 1 | Bronchial, Hyperplasia | 2 | 1 2.0| |__________________________________________________________________________|____________| Lymph Node, Mandibular | + + + + + + + + + + | 10 | Hyperplasia, Lymphoid | 2 | 1 2.0| |__________________________________________________________________________|____________| Lymph Node, Mesenteric | + + + + + + + + + + | 10 | |__________________________________________________________________________|____________| Spleen | + + + + + + + + + + | 10 | _____________________________________________________________________________________________________________________|____________| * : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade + : Tissue examined microscopically M : Missing tissue 1-4 : Lesion qualified as: X : Lesion present but not qualified A : Autolysis precludes examination 1) Minimal 3) Moderate I : Insufficient tissue BLANK : Not examined 2) Mild 4) Marked Page 15 NTP Experiment-Test: 97013-93 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09 Study Type: 26-39 WEEKS WATER DISINFECTION MODEL (SODIUM BROMATE) Date: 12/08/03 Route: DOSED WATER Time: 14:36:57 __________________________________________________________________________________________________________________________________ | 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| | | DAY ON TEST | 9| 9| 9| 9| 9| 9| 9| 9| 7| 9| | | | 5| 5| 5| 5| 5| 5| 5| 5| 6| 5| | | __________________________________________|__________________________________________________________________________| T (*) | | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | O | P53+/-(C57BL/6) MALE | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| | T | ANIMAL ID | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| | A | 0 MG/L | 0| 0| 0| 0| 0| 0| 0| 0| 0| 1| | L | | 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| | | _____________________________________________________________________________________________________________________|____________| HEMATOPOIETIC SYSTEM - cont | | | Hematopoietic Cell Proliferation | 3 | 1 3.0| |__________________________________________________________________________|____________| Thymus | + + + + + + + + + + | 10 | Atrophy | 3 | 1 3.0| Cyst | 1 1 1 2 1 | 5 1.2| _____________________________________________________________________________________________________________________| | INTEGUMENTARY SYSTEM | | | |__________________________________________________________________________|____________| Skin | + | 1 | _____________________________________________________________________________________________________________________| | MUSCULOSKELETAL SYSTEM | | | |__________________________________________________________________________|____________| Bone | + | 1 | _____________________________________________________________________________________________________________________| | NERVOUS SYSTEM | | | None | | | _____________________________________________________________________________________________________________________| | RESPIRATORY SYSTEM | | | |__________________________________________________________________________|____________| Lung | + + + + + + + + + + | 10 | Hemorrhage | 1 | 1 1.0| _____________________________________________________________________________________________________________________| | SPECIAL SENSES SYSTEM | | | None | | | _____________________________________________________________________________________________________________________| | URINARY SYSTEM | | | |__________________________________________________________________________|____________| Kidney | + + + + + + + + + + | 10 | Infarct | 2 | 1 2.0| Nephropathy | 1 3 1 1 1 1 1 1 1 | 9 1.2| __________________________________________________________________________________________________________________________________ * : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade + : Tissue examined microscopically M : Missing tissue 1-4 : Lesion qualified as: X : Lesion present but not qualified A : Autolysis precludes examination 1) Minimal 3) Moderate I : Insufficient tissue BLANK : Not examined 2) Mild 4) Marked Page 16 NTP Experiment-Test: 97013-93 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09 Study Type: 26-39 WEEKS WATER DISINFECTION MODEL (SODIUM BROMATE) Date: 12/08/03 Route: DOSED WATER Time: 14:36:57 __________________________________________________________________________________________________________________________________ | 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| | | DAY ON TEST | 1| 5| 9| 9| 9| 9| 9| 9| 9| 9| | | | 8| 8| 5| 5| 5| 5| 5| 5| 5| 5| | | __________________________________________|__________________________________________________________________________| T (*) | | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | O | P53+/-(C57BL/6) MALE | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| | T | ANIMAL ID | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| | A | 80 MG/L | 1| 1| 1| 1| 1| 1| 1| 1| 1| 2| | L | | 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| | | _____________________________________________________________________________________________________________________|____________| ALIMENTARY SYSTEM | | | |__________________________________________________________________________|____________| Intestine Large, Colon | + + + + + + + + + + | 10 | |__________________________________________________________________________|____________| Intestine Large, Cecum | + + + + + + + + + + | 10 | |__________________________________________________________________________|____________| Intestine Small, Duodenum | + + + + + + + + + + | 10 | |__________________________________________________________________________|____________| Intestine Small, Jejunum | + + + + + + + + + + | 10 | |__________________________________________________________________________|____________| Intestine Small, Ileum | + + + + + + + + + + | 10 | |__________________________________________________________________________|____________| Liver | + + + + + + + + + + | 10 | Inflammation, Chronic Active | 1 1 1 1 1 1 | 6 1.0| Hepatocyte, Fatty Change | 2 1 1 1 2 1 1 1 1 | 9 1.2| Hepatocyte, Vacuolization Cytoplasmic| 3 3 4 3 4 3 3 3 3 | 9 3.2| |__________________________________________________________________________|____________| Stomach, Forestomach | + + + + + + + + + + | 10 | Inflammation, Chronic Active | 2 2 | 2 2.0| Epithelium, Hyperkeratosis | 2 2 1 | 3 1.7| Epithelium, Hyperplasia | 3 3 2 2 | 4 2.5| _____________________________________________________________________________________________________________________| | CARDIOVASCULAR SYSTEM | | | None | | | _____________________________________________________________________________________________________________________| | ENDOCRINE SYSTEM | | | |__________________________________________________________________________|____________| Adrenal Cortex | + + + + + + + + + + | 10 | Hypertrophy | 2 | 1 2.0| Inflammation, Chronic Active | 1 | 1 1.0| Subcapsular, Hyperplasia | 1 1 1 | 3 1.0| |__________________________________________________________________________|____________| Adrenal Medulla | + + + + + + + + + + | 10 | |__________________________________________________________________________|____________| Pituitary Gland | M + + + + + + + + + | 9 | _____________________________________________________________________________________________________________________|____________| * : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade + : Tissue examined microscopically M : Missing tissue 1-4 : Lesion qualified as: X : Lesion present but not qualified A : Autolysis precludes examination 1) Minimal 3) Moderate I : Insufficient tissue BLANK : Not examined 2) Mild 4) Marked Page 17 NTP Experiment-Test: 97013-93 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09 Study Type: 26-39 WEEKS WATER DISINFECTION MODEL (SODIUM BROMATE) Date: 12/08/03 Route: DOSED WATER Time: 14:36:57 __________________________________________________________________________________________________________________________________ | 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| | | DAY ON TEST | 1| 5| 9| 9| 9| 9| 9| 9| 9| 9| | | | 8| 8| 5| 5| 5| 5| 5| 5| 5| 5| | | __________________________________________|__________________________________________________________________________| T (*) | | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | O | P53+/-(C57BL/6) MALE | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| | T | ANIMAL ID | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| | A | 80 MG/L | 1| 1| 1| 1| 1| 1| 1| 1| 1| 2| | L | | 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| | | _____________________________________________________________________________________________________________________|____________| ENDOCRINE SYSTEM - cont | | | Pars Distalis, Cyst | 1 | 1 1.0| |__________________________________________________________________________|____________| Thyroid Gland | + + + + + + + + + + | 10 | _____________________________________________________________________________________________________________________| | GENERAL BODY SYSTEM | | | None | | | _____________________________________________________________________________________________________________________| | GENITAL SYSTEM | | | |__________________________________________________________________________|____________| Epididymis | + + + + + + + + + + | 10 | Degeneration | 3 3 | 2 3.0| Inflammation, Chronic Active | 2 2 | 2 2.0| |__________________________________________________________________________|____________| Testes | + + + + + + + + + + | 10 | Mineralization | 2 2 | 2 2.0| Germinal Epithelium, Degeneration | 2 1 3 1 | 4 1.8| _____________________________________________________________________________________________________________________| | HEMATOPOIETIC SYSTEM | | | |__________________________________________________________________________|____________| Lymph Node, Mandibular | + + + + + + + + + + | 10 | |__________________________________________________________________________|____________| Lymph Node, Mesenteric | + + + + + + + + + + | 10 | |__________________________________________________________________________|____________| Spleen | + + + + + + + + + + | 10 | Hematopoietic Cell Proliferation | 2 | 1 2.0| |__________________________________________________________________________|____________| Thymus | + + + + + + + + + + | 10 | Cyst | 1 2 2 1 | 4 1.5| _____________________________________________________________________________________________________________________| | INTEGUMENTARY SYSTEM | | | |__________________________________________________________________________|____________| Skin | + | 1 | _____________________________________________________________________________________________________________________| | MUSCULOSKELETAL SYSTEM | | | None | | | _____________________________________________________________________________________________________________________|____________| * : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade + : Tissue examined microscopically M : Missing tissue 1-4 : Lesion qualified as: X : Lesion present but not qualified A : Autolysis precludes examination 1) Minimal 3) Moderate I : Insufficient tissue BLANK : Not examined 2) Mild 4) Marked Page 18 NTP Experiment-Test: 97013-93 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09 Study Type: 26-39 WEEKS WATER DISINFECTION MODEL (SODIUM BROMATE) Date: 12/08/03 Route: DOSED WATER Time: 14:36:57 __________________________________________________________________________________________________________________________________ | 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| | | DAY ON TEST | 1| 5| 9| 9| 9| 9| 9| 9| 9| 9| | | | 8| 8| 5| 5| 5| 5| 5| 5| 5| 5| | | __________________________________________|__________________________________________________________________________| T (*) | | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | O | P53+/-(C57BL/6) MALE | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| | T | ANIMAL ID | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| | A | 80 MG/L | 1| 1| 1| 1| 1| 1| 1| 1| 1| 2| | L | | 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| | | _____________________________________________________________________________________________________________________|____________| NERVOUS SYSTEM | | | None | | | _____________________________________________________________________________________________________________________| | RESPIRATORY SYSTEM | | | |__________________________________________________________________________|____________| Lung | + + + + + + + + + + | 10 | _____________________________________________________________________________________________________________________| | SPECIAL SENSES SYSTEM | | | None | | | _____________________________________________________________________________________________________________________| | URINARY SYSTEM | | | |__________________________________________________________________________|____________| Kidney | + + + + + + + + + + | 10 | Nephropathy | 1 1 1 1 1 1 1 | 7 1.0| Papilla, Mineralization | 1 | 1 1.0| __________________________________________________________________________________________________________________________________ * : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade + : Tissue examined microscopically M : Missing tissue 1-4 : Lesion qualified as: X : Lesion present but not qualified A : Autolysis precludes examination 1) Minimal 3) Moderate I : Insufficient tissue BLANK : Not examined 2) Mild 4) Marked Page 19 NTP Experiment-Test: 97013-93 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09 Study Type: 26-39 WEEKS WATER DISINFECTION MODEL (SODIUM BROMATE) Date: 12/08/03 Route: DOSED WATER Time: 14:36:57 __________________________________________________________________________________________________________________________________ | 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| | | DAY ON TEST | 9| 9| 9| 9| 9| 9| 8| 9| 4| 9| | | | 5| 5| 5| 5| 5| 5| 6| 5| 4| 5| | | __________________________________________|__________________________________________________________________________| T (*) | | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | O | P53+/-(C57BL/6) MALE | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| | T | ANIMAL ID | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| | A | 400 MG/L | 2| 2| 2| 2| 2| 2| 2| 2| 2| 3| | L | | 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| | | _____________________________________________________________________________________________________________________|____________| ALIMENTARY SYSTEM | | | |__________________________________________________________________________|____________| Intestine Large, Colon | + + + + + + + + + + | 10 | |__________________________________________________________________________|____________| Intestine Large, Cecum | + + + + + + + + + + | 10 | |__________________________________________________________________________|____________| Intestine Small, Duodenum | + + + + + + + + + + | 10 | |__________________________________________________________________________|____________| Intestine Small, Jejunum | + + + + + + + + + + | 10 | |__________________________________________________________________________|____________| Intestine Small, Ileum | + + + + + + + + + + | 10 | |__________________________________________________________________________|____________| Liver | + + + + + + + + + + | 10 | Inflammation, Chronic Active | 1 1 1 1 1 1 1 1 | 8 1.0| Hepatocyte, Fatty Change | 1 1 1 1 1 2 1 1 1 | 9 1.1| Hepatocyte, Vacuolization Cytoplasmic| 2 3 3 3 4 4 1 3 1 3 | 10 2.7| |__________________________________________________________________________|____________| Stomach, Forestomach | + + + + + + + + + + | 10 | Epithelium, Hyperkeratosis | 2 | 1 2.0| _____________________________________________________________________________________________________________________| | CARDIOVASCULAR SYSTEM | | | None | | | _____________________________________________________________________________________________________________________| | ENDOCRINE SYSTEM | | | |__________________________________________________________________________|____________| Adrenal Cortex | + + + + + + + + + + | 10 | Accessory Adrenal Cortical Nodule | 1 | 1 1.0| Hyperplasia | 3 | 1 3.0| Hypertrophy | 1 | 1 1.0| Subcapsular, Hyperplasia | 1 1 | 2 1.0| |__________________________________________________________________________|____________| Adrenal Medulla | + + + + + + + + + + | 10 | |__________________________________________________________________________|____________| Pituitary Gland | + + + + + + + + + + | 10 | Pars Distalis, Cyst | 1 1 1 | 3 1.0| _____________________________________________________________________________________________________________________|____________| * : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade + : Tissue examined microscopically M : Missing tissue 1-4 : Lesion qualified as: X : Lesion present but not qualified A : Autolysis precludes examination 1) Minimal 3) Moderate I : Insufficient tissue BLANK : Not examined 2) Mild 4) Marked Page 20 NTP Experiment-Test: 97013-93 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09 Study Type: 26-39 WEEKS WATER DISINFECTION MODEL (SODIUM BROMATE) Date: 12/08/03 Route: DOSED WATER Time: 14:36:57 __________________________________________________________________________________________________________________________________ | 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| | | DAY ON TEST | 9| 9| 9| 9| 9| 9| 8| 9| 4| 9| | | | 5| 5| 5| 5| 5| 5| 6| 5| 4| 5| | | __________________________________________|__________________________________________________________________________| T (*) | | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | O | P53+/-(C57BL/6) MALE | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| | T | ANIMAL ID | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| | A | 400 MG/L | 2| 2| 2| 2| 2| 2| 2| 2| 2| 3| | L | | 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| | | _____________________________________________________________________________________________________________________|____________| ENDOCRINE SYSTEM - cont | | | Pars Distalis, Hyperplasia | 2 | 1 2.0| |__________________________________________________________________________|____________| Thyroid Gland | + + + + + + + + + + | 10 | _____________________________________________________________________________________________________________________| | GENERAL BODY SYSTEM | | | None | | | _____________________________________________________________________________________________________________________| | GENITAL SYSTEM | | | |__________________________________________________________________________|____________| Epididymis | + + + + + + + + + + | 10 | |__________________________________________________________________________|____________| Seminal Vesicle | + | 1 | |__________________________________________________________________________|____________| Testes | + + + + + + + + + + | 10 | Germinal Epithelium, Degeneration | 1 1 1 1 1 | 5 1.0| _____________________________________________________________________________________________________________________| | HEMATOPOIETIC SYSTEM | | | |__________________________________________________________________________|____________| Lymph Node, Mandibular | + + + + + + + + + + | 10 | Hyperplasia, Lymphoid | 2 2 | 2 2.0| |__________________________________________________________________________|____________| Lymph Node, Mesenteric | + + + + + + + + + + | 10 | Hyperplasia, Lymphoid | 3 | 1 3.0| |__________________________________________________________________________|____________| Spleen | + + + + + + + + M + | 9 | Atrophy | 3 | 1 3.0| |__________________________________________________________________________|____________| Thymus | + + + + + + + + + + | 10 | Atrophy | 4 | 1 4.0| Cyst | 2 1 | 2 1.5| _____________________________________________________________________________________________________________________| | INTEGUMENTARY SYSTEM | | | |__________________________________________________________________________|____________| Mammary Gland | + | 1 | _____________________________________________________________________________________________________________________| | MUSCULOSKELETAL SYSTEM | | | None | | | _____________________________________________________________________________________________________________________|____________| * : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade + : Tissue examined microscopically M : Missing tissue 1-4 : Lesion qualified as: X : Lesion present but not qualified A : Autolysis precludes examination 1) Minimal 3) Moderate I : Insufficient tissue BLANK : Not examined 2) Mild 4) Marked Page 21 NTP Experiment-Test: 97013-93 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09 Study Type: 26-39 WEEKS WATER DISINFECTION MODEL (SODIUM BROMATE) Date: 12/08/03 Route: DOSED WATER Time: 14:36:57 __________________________________________________________________________________________________________________________________ | 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| | | DAY ON TEST | 9| 9| 9| 9| 9| 9| 8| 9| 4| 9| | | | 5| 5| 5| 5| 5| 5| 6| 5| 4| 5| | | __________________________________________|__________________________________________________________________________| T (*) | | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | O | P53+/-(C57BL/6) MALE | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| | T | ANIMAL ID | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| | A | 400 MG/L | 2| 2| 2| 2| 2| 2| 2| 2| 2| 3| | L | | 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| | | _____________________________________________________________________________________________________________________|____________| NERVOUS SYSTEM | | | None | | | _____________________________________________________________________________________________________________________| | RESPIRATORY SYSTEM | | | |__________________________________________________________________________|____________| Lung | + + + + + + + + + + | 10 | Inflammation, Chronic Active | 1 | 1 1.0| _____________________________________________________________________________________________________________________| | SPECIAL SENSES SYSTEM | | | None | | | _____________________________________________________________________________________________________________________| | URINARY SYSTEM | | | |__________________________________________________________________________|____________| Kidney | + + + + + + + + A + | 9 | Mineralization | 1 | 1 1.0| Nephropathy | 1 1 1 1 1 1 1 | 7 1.0| Cortex, Mineralization | 1 | 1 1.0| __________________________________________________________________________________________________________________________________ * : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade + : Tissue examined microscopically M : Missing tissue 1-4 : Lesion qualified as: X : Lesion present but not qualified A : Autolysis precludes examination 1) Minimal 3) Moderate I : Insufficient tissue BLANK : Not examined 2) Mild 4) Marked Page 22 NTP Experiment-Test: 97013-93 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09 Study Type: 26-39 WEEKS WATER DISINFECTION MODEL (SODIUM BROMATE) Date: 12/08/03 Route: DOSED WATER Time: 14:36:57 __________________________________________________________________________________________________________________________________ | 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| | | DAY ON TEST | 9| 9| 9| 9| 9| 9| 9| 9| 2| 9| | | | 5| 5| 5| 5| 5| 5| 5| 5| 3| 5| | | __________________________________________|__________________________________________________________________________| T (*) | | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | O | P53+/-(C57BL/6) MALE | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| | T | ANIMAL ID | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| | A | 800 MG/L | 3| 3| 3| 3| 3| 3| 3| 3| 3| 4| | L | | 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| | | _____________________________________________________________________________________________________________________|____________| ALIMENTARY SYSTEM | | | |__________________________________________________________________________|____________| Intestine Large, Colon | + + + + + + + + + + | 10 | |__________________________________________________________________________|____________| Intestine Large, Cecum | + + + + + + + + + + | 10 | |__________________________________________________________________________|____________| Intestine Small, Duodenum | + + + + + + + + + + | 10 | |__________________________________________________________________________|____________| Intestine Small, Jejunum | + + + + + + + + + + | 10 | |__________________________________________________________________________|____________| Intestine Small, Ileum | + + + + + + + + + + | 10 | |__________________________________________________________________________|____________| Liver | + + + + + + + + + + | 10 | Infiltration Cellular, Mononuclear | | | Cell | 2 | 1 2.0| Inflammation, Chronic Active | 1 1 1 1 1 1 1 1 2 | 9 1.1| Hepatocyte, Fatty Change | 1 1 1 1 3 2 | 6 1.5| Hepatocyte, Vacuolization Cytoplasmic| 3 3 4 3 3 4 3 4 1 3 | 10 3.1| |__________________________________________________________________________|____________| Salivary Glands | + | 1 | Duct, Hyperplasia | 1 | 1 1.0| |__________________________________________________________________________|____________| Stomach, Forestomach | + + + + + + + + + + | 10 | Epithelium, Hyperplasia | 2 2 2 | 3 2.0| _____________________________________________________________________________________________________________________| | CARDIOVASCULAR SYSTEM | | | None | | | _____________________________________________________________________________________________________________________| | ENDOCRINE SYSTEM | | | |__________________________________________________________________________|____________| Adrenal Cortex | + + + + + + + + + + | 10 | Accessory Adrenal Cortical Nodule | 2 | 1 2.0| Hypertrophy | 1 1 1 | 3 1.0| Subcapsular, Hyperplasia | 1 1 1 | 3 1.0| |__________________________________________________________________________|____________| _____________________________________________________________________________________________________________________|____________| * : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade + : Tissue examined microscopically M : Missing tissue 1-4 : Lesion qualified as: X : Lesion present but not qualified A : Autolysis precludes examination 1) Minimal 3) Moderate I : Insufficient tissue BLANK : Not examined 2) Mild 4) Marked Page 23 NTP Experiment-Test: 97013-93 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09 Study Type: 26-39 WEEKS WATER DISINFECTION MODEL (SODIUM BROMATE) Date: 12/08/03 Route: DOSED WATER Time: 14:36:57 __________________________________________________________________________________________________________________________________ | 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| | | DAY ON TEST | 9| 9| 9| 9| 9| 9| 9| 9| 2| 9| | | | 5| 5| 5| 5| 5| 5| 5| 5| 3| 5| | | __________________________________________|__________________________________________________________________________| T (*) | | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | O | P53+/-(C57BL/6) MALE | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| | T | ANIMAL ID | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| | A | 800 MG/L | 3| 3| 3| 3| 3| 3| 3| 3| 3| 4| | L | | 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| | | _____________________________________________________________________________________________________________________|____________| ENDOCRINE SYSTEM - cont | | | Adrenal Medulla | + + + + + + + + + + | 10 | |__________________________________________________________________________|____________| Pituitary Gland | + + + + + + + + M + | 9 | Pars Distalis, Cyst | 1 | 1 1.0| |__________________________________________________________________________|____________| Thyroid Gland | + + + + + + + + M + | 9 | _____________________________________________________________________________________________________________________| | GENERAL BODY SYSTEM | | | None | | | _____________________________________________________________________________________________________________________| | GENITAL SYSTEM | | | |__________________________________________________________________________|____________| Epididymis | + + + + + + + + + + | 10 | Infiltration Cellular, Lymphocyte | 2 1 | 2 1.5| |__________________________________________________________________________|____________| Testes | + + + + + + + + + + | 10 | Germinal Epithelium, Degeneration | 1 | 1 1.0| _____________________________________________________________________________________________________________________| | HEMATOPOIETIC SYSTEM | | | |__________________________________________________________________________|____________| Lymph Node | + | 1 | Mediastinal, Hyperplasia, Lymphoid | 3 | 1 3.0| |__________________________________________________________________________|____________| Lymph Node, Mandibular | + + + + + + + + + + | 10 | Hyperplasia, Lymphoid | 2 | 1 2.0| |__________________________________________________________________________|____________| Lymph Node, Mesenteric | + + + + + + + + + + | 10 | Hyperplasia, Lymphoid | 3 2 | 2 2.5| |__________________________________________________________________________|____________| Spleen | + + + + + + + + + + | 10 | |__________________________________________________________________________|____________| Thymus | + + + + + + + + + + | 10 | Atrophy | 4 | 1 4.0| Cyst | 1 2 1 1 1 2 1 | 7 1.3| _____________________________________________________________________________________________________________________|____________| * : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade + : Tissue examined microscopically M : Missing tissue 1-4 : Lesion qualified as: X : Lesion present but not qualified A : Autolysis precludes examination 1) Minimal 3) Moderate I : Insufficient tissue BLANK : Not examined 2) Mild 4) Marked Page 24 NTP Experiment-Test: 97013-93 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09 Study Type: 26-39 WEEKS WATER DISINFECTION MODEL (SODIUM BROMATE) Date: 12/08/03 Route: DOSED WATER Time: 14:36:57 __________________________________________________________________________________________________________________________________ | 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| | | DAY ON TEST | 9| 9| 9| 9| 9| 9| 9| 9| 2| 9| | | | 5| 5| 5| 5| 5| 5| 5| 5| 3| 5| | | __________________________________________|__________________________________________________________________________| T (*) | | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | O | P53+/-(C57BL/6) MALE | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| | T | ANIMAL ID | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| | A | 800 MG/L | 3| 3| 3| 3| 3| 3| 3| 3| 3| 4| | L | | 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| | | _____________________________________________________________________________________________________________________|____________| HEMATOPOIETIC SYSTEM - cont | | | Ectopic Parathyroid Gland | 1 | 1 1.0| _____________________________________________________________________________________________________________________| | INTEGUMENTARY SYSTEM | | | None | | | _____________________________________________________________________________________________________________________| | MUSCULOSKELETAL SYSTEM | | | None | | | _____________________________________________________________________________________________________________________| | NERVOUS SYSTEM | | | None | | | _____________________________________________________________________________________________________________________| | RESPIRATORY SYSTEM | | | |__________________________________________________________________________|____________| Lung | + + + + + + + + + + | 10 | _____________________________________________________________________________________________________________________| | SPECIAL SENSES SYSTEM | | | None | | | _____________________________________________________________________________________________________________________| | URINARY SYSTEM | | | |__________________________________________________________________________|____________| Kidney | + + + + + + + + + + | 10 | Nephropathy | 1 1 1 1 1 2 1 | 7 1.1| Papilla, Mineralization | 1 | 1 1.0| Pelvis, Dilatation | 2 | 1 2.0| __________________________________________________________________________________________________________________________________ * : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade + : Tissue examined microscopically M : Missing tissue 1-4 : Lesion qualified as: X : Lesion present but not qualified A : Autolysis precludes examination 1) Minimal 3) Moderate I : Insufficient tissue BLANK : Not examined 2) Mild 4) Marked Page 25 ------------------------------------------------------------ ---------- END OF REPORT ---------- ------------------------------------------------------------