TDMS Study 97013-93 Pathology Tables
NTP Experiment-Test: 97013-93 INCIDENCE RATES OF NONNEOPLASTIC LESIONS BY ANATOMIC SITE (a) Report: PEIRPT18
Study Type: 26-39 WEEKS WITH AVERAGE SEVERITY GRADES[b] Date: 12/08/03
Route: DOSED WATER WATER DISINFECTION MODEL (SODIUM BROMATE) Time: 14:39:02
FINAL#1 MICE
Facility: Battelle Columbus Laboratory
Chemical CAS #: 7789-38-0
Lock Date: 07/30/01
Cage Range: All
Reasons For Removal: All
Removal Date Range: All
Treatment Groups: Include All
a Number of animals examined microscopically at site and number of animals with lesion
b Average severity grade (1-minimal;2-mild;3-moderate;4-marked)
Page 1
NTP Experiment-Test: 97013-93 INCIDENCE RATES OF NONNEOPLASTIC LESIONS BY ANATOMIC SITE (a) Report: PEIRPT18
Study Type: 26-39 WEEKS WITH AVERAGE SEVERITY GRADES[b] Date: 12/08/03
Route: DOSED WATER WATER DISINFECTION MODEL (SODIUM BROMATE) Time: 14:39:02
____________________________________________________________________________________________________________________________________
P53+/-(C57BL/6) FEMALE 0 MG/L 80 MG/L 400 MG/L 800 MG/L
____________________________________________________________________________________________________________________________________
DISPOSITION SUMMARY
Animals Initially In Study 10 10 10 10
Early Deaths
Natural Death 1
Moribund Sacrifice 1
Survivors
Terminal Sacrifice 9 9 10 10
Animals Examined Microscopically 10 10 10 10
____________________________________________________________________________________________________________________________________
ALIMENTARY SYSTEM
Liver (10) (10) (10) (10)
Angiectasis 2 [1.5]
Hematopoietic Cell Proliferation 1 [2.0]
Inflammation, Chronic Active 9 [1.1] 10 [1.0] 8 [1.0] 10 [1.1]
Mixed Cell Focus 1
Hepatocyte, Fatty Change 1 [1.0] 1 [1.0]
Hepatocyte, Vacuolization Cytoplasmic 9 [1.1] 10 [1.2] 8 [1.4] 10 [1.2]
Stomach, Forestomach (10) (10) (10) (10)
Inflammation, Chronic Active 1 [2.0]
Epithelium, Hyperkeratosis 2 [2.0] 1 [1.0] 1 [1.0]
Epithelium, Hyperplasia 2 [2.5] 1 [2.0] 3 [2.0]
Epithelium, Ulcer 1 [2.0]
____________________________________________________________________________________________________________________________________
CARDIOVASCULAR SYSTEM
None
____________________________________________________________________________________________________________________________________
ENDOCRINE SYSTEM
Adrenal Cortex (10) (10) (10) (10)
Accessory Adrenal Cortical Nodule 1 [2.0] 1 [2.0]
Infiltration Cellular, Lymphocyte 1 [1.0] 1 [1.0]
Subcapsular, Hyperplasia 8 [1.1] 9 [1.0] 10 [1.1] 10 [1.1]
Pituitary Gland (10) (10) (10) (10)
Pars Distalis, Cyst 2 [1.0] 1 [1.0]
Pars Distalis, Hyperplasia 1 [1.0] 2 [2.0]
Thyroid Gland (10) (10) (10) (10)
Ectopic Thymus 1 [1.0]
a Number of animals examined microscopically at site and number of animals with lesion
b Average severity grade (1-minimal;2-mild;3-moderate;4-marked)
Page 2
NTP Experiment-Test: 97013-93 INCIDENCE RATES OF NONNEOPLASTIC LESIONS BY ANATOMIC SITE (a) Report: PEIRPT18
Study Type: 26-39 WEEKS WITH AVERAGE SEVERITY GRADES[b] Date: 12/08/03
Route: DOSED WATER WATER DISINFECTION MODEL (SODIUM BROMATE) Time: 14:39:02
____________________________________________________________________________________________________________________________________
P53+/-(C57BL/6) FEMALE 0 MG/L 80 MG/L 400 MG/L 800 MG/L
____________________________________________________________________________________________________________________________________
ENDOCRINE SYSTEM - CONT
Infiltration Cellular, Lymphocyte 2 [1.0] 1 [1.0] 1 [1.0]
Follicle, Cyst 2 [2.0]
____________________________________________________________________________________________________________________________________
GENERAL BODY SYSTEM
None
____________________________________________________________________________________________________________________________________
GENITAL SYSTEM
Ovary (10) (10) (10) (10)
Atrophy 1 [3.0]
Cyst 3 [2.3] 2 [3.0] 1 [2.0] 2 [2.5]
Bilateral, Cyst 1 [3.0]
Uterus (10) (10) (10) (10)
Inflammation, Suppurative 1 [2.0]
Endometrium, Hyperplasia, Cystic 9 [1.8] 10 [1.7] 8 [1.6] 8 [1.8]
____________________________________________________________________________________________________________________________________
HEMATOPOIETIC SYSTEM
Lymph Node, Mandibular (10) (10) (10) (10)
Hyperplasia, Lymphoid 1 [3.0] 1 [2.0] 1 [2.0] 2 [2.0]
Lymph Node, Mesenteric (10) (10) (10) (10)
Hyperplasia, Lymphoid 1 [3.0]
Spleen (10) (10) (10) (10)
Hematopoietic Cell Proliferation 1 [3.0] 1 [3.0]
Hyperplasia, Lymphoid 1 [3.0]
Thymus (10) (10) (10) (10)
Cyst 2 [1.0] 4 [1.0] 5 [1.2] 3 [1.7]
Ectopic Parathyroid Gland 1 [1.0] 1 [1.0]
Ectopic Thyroid 1 [1.0]
____________________________________________________________________________________________________________________________________
INTEGUMENTARY SYSTEM
Skin (1) (1) (1)
Hyperkeratosis 1 [2.0]
Hyperplasia 1 [3.0]
Inflammation, Chronic Active 1 [3.0] 1 [4.0]
Ulcer 1 [4.0]
____________________________________________________________________________________________________________________________________
a Number of animals examined microscopically at site and number of animals with lesion
b Average severity grade (1-minimal;2-mild;3-moderate;4-marked)
Page 3
NTP Experiment-Test: 97013-93 INCIDENCE RATES OF NONNEOPLASTIC LESIONS BY ANATOMIC SITE (a) Report: PEIRPT18
Study Type: 26-39 WEEKS WITH AVERAGE SEVERITY GRADES[b] Date: 12/08/03
Route: DOSED WATER WATER DISINFECTION MODEL (SODIUM BROMATE) Time: 14:39:02
____________________________________________________________________________________________________________________________________
P53+/-(C57BL/6) FEMALE 0 MG/L 80 MG/L 400 MG/L 800 MG/L
____________________________________________________________________________________________________________________________________
MUSCULOSKELETAL SYSTEM
None
____________________________________________________________________________________________________________________________________
NERVOUS SYSTEM
None
____________________________________________________________________________________________________________________________________
RESPIRATORY SYSTEM
Lung (10) (10) (10) (9)
Alveolar Epithelium, Hyperplasia 1 [2.0]
Perivascular, Infiltration Cellular,
Lymphocyte 4 [2.0] 3 [1.7] 4 [2.3] 2 [2.0]
____________________________________________________________________________________________________________________________________
SPECIAL SENSES SYSTEM
None
____________________________________________________________________________________________________________________________________
URINARY SYSTEM
Kidney (10) (10) (10) (10)
Mineralization 1 [1.0] 1 [1.0]
Nephropathy 7 [1.1] 7 [1.0] 6 [1.0] 8 [1.0]
Papilla, Mineralization 1 [1.0]
a Number of animals examined microscopically at site and number of animals with lesion
b Average severity grade (1-minimal;2-mild;3-moderate;4-marked)
Page 4
NTP Experiment-Test: 97013-93 INCIDENCE RATES OF NONNEOPLASTIC LESIONS BY ANATOMIC SITE (a) Report: PEIRPT18
Study Type: 26-39 WEEKS WITH AVERAGE SEVERITY GRADES[b] Date: 12/08/03
Route: DOSED WATER WATER DISINFECTION MODEL (SODIUM BROMATE) Time: 14:39:02
____________________________________________________________________________________________________________________________________
P53+/-(C57BL/6) MALE 0 MG/L 80 MG/L 400 MG/L 800 MG/L
____________________________________________________________________________________________________________________________________
DISPOSITION SUMMARY
Animals Initially In Study 10 10 10 10
Early Deaths
Moribund Sacrifice 1 2
Natural Death 2 1
Survivors
Terminal Sacrifice 9 8 8 9
Animals Examined Microscopically 10 10 10 10
____________________________________________________________________________________________________________________________________
ALIMENTARY SYSTEM
Liver (10) (10) (10) (10)
Infiltration Cellular, Mononuclear Cell 1 [2.0]
Inflammation, Chronic Active 9 [1.0] 6 [1.0] 8 [1.0] 9 [1.1]
Hepatocyte, Fatty Change 7 [1.9] 9 [1.2] 9 [1.1] 6 [1.5]
Hepatocyte, Necrosis 1 [1.0]
Hepatocyte, Vacuolization Cytoplasmic 9 [3.0] 9 [3.2] 10 [2.7] 10 [3.1]
Salivary Glands (1)
Duct, Hyperplasia 1 [1.0]
Stomach, Forestomach (10) (10) (10) (10)
Inflammation, Chronic Active 1 [2.0] 2 [2.0]
Epithelium, Hyperkeratosis 1 [2.0] 3 [1.7] 1 [2.0]
Epithelium, Hyperplasia 2 [2.0] 4 [2.5] 3 [2.0]
Epithelium, Ulcer 1 [2.0]
____________________________________________________________________________________________________________________________________
CARDIOVASCULAR SYSTEM
None
____________________________________________________________________________________________________________________________________
ENDOCRINE SYSTEM
Adrenal Cortex (10) (10) (10) (10)
Accessory Adrenal Cortical Nodule 1 [1.0] 1 [2.0]
Hyperplasia 1 [3.0]
Hypertrophy 1 [1.0] 1 [2.0] 1 [1.0] 3 [1.0]
Inflammation, Chronic Active 1 [1.0]
Subcapsular, Hyperplasia 3 [1.0] 3 [1.0] 2 [1.0] 3 [1.0]
Pituitary Gland (10) (9) (10) (9)
Pars Distalis, Cyst 3 [1.0] 1 [1.0] 3 [1.0] 1 [1.0]
a Number of animals examined microscopically at site and number of animals with lesion
b Average severity grade (1-minimal;2-mild;3-moderate;4-marked)
Page 5
NTP Experiment-Test: 97013-93 INCIDENCE RATES OF NONNEOPLASTIC LESIONS BY ANATOMIC SITE (a) Report: PEIRPT18
Study Type: 26-39 WEEKS WITH AVERAGE SEVERITY GRADES[b] Date: 12/08/03
Route: DOSED WATER WATER DISINFECTION MODEL (SODIUM BROMATE) Time: 14:39:02
____________________________________________________________________________________________________________________________________
P53+/-(C57BL/6) MALE 0 MG/L 80 MG/L 400 MG/L 800 MG/L
____________________________________________________________________________________________________________________________________
ENDOCRINE SYSTEM - CONT
Pars Distalis, Hyperplasia 1 [2.0]
Thyroid Gland (10) (10) (10) (9)
Infiltration Cellular, Lymphocyte 1 [1.0]
____________________________________________________________________________________________________________________________________
GENERAL BODY SYSTEM
None
____________________________________________________________________________________________________________________________________
GENITAL SYSTEM
Epididymis (10) (10) (10) (10)
Atrophy 1 [4.0]
Degeneration 2 [3.0]
Infiltration Cellular, Lymphocyte 2 [1.5]
Inflammation, Chronic Active 2 [2.0]
Testes (10) (10) (10) (10)
Mineralization 2 [2.0]
Germinal Epithelium, Degeneration 2 [1.0] 4 [1.8] 5 [1.0] 1 [1.0]
Germinal Epithelium, Necrosis 1 [4.0]
____________________________________________________________________________________________________________________________________
HEMATOPOIETIC SYSTEM
Lymph Node (1) (1)
Bronchial, Hyperplasia 1 [2.0]
Mediastinal, Hyperplasia, Lymphoid 1 [3.0]
Lymph Node, Mandibular (10) (10) (10) (10)
Hyperplasia, Lymphoid 1 [2.0] 2 [2.0] 1 [2.0]
Lymph Node, Mesenteric (10) (10) (10) (10)
Hyperplasia, Lymphoid 1 [3.0] 2 [2.5]
Spleen (10) (10) (9) (10)
Atrophy 1 [3.0]
Hematopoietic Cell Proliferation 1 [3.0] 1 [2.0]
Thymus (10) (10) (10) (10)
Atrophy 1 [3.0] 1 [4.0] 1 [4.0]
Cyst 5 [1.2] 4 [1.5] 2 [1.5] 7 [1.3]
Ectopic Parathyroid Gland 1 [1.0]
____________________________________________________________________________________________________________________________________
INTEGUMENTARY SYSTEM
a Number of animals examined microscopically at site and number of animals with lesion
b Average severity grade (1-minimal;2-mild;3-moderate;4-marked)
Page 6
NTP Experiment-Test: 97013-93 INCIDENCE RATES OF NONNEOPLASTIC LESIONS BY ANATOMIC SITE (a) Report: PEIRPT18
Study Type: 26-39 WEEKS WITH AVERAGE SEVERITY GRADES[b] Date: 12/08/03
Route: DOSED WATER WATER DISINFECTION MODEL (SODIUM BROMATE) Time: 14:39:02
____________________________________________________________________________________________________________________________________
P53+/-(C57BL/6) MALE 0 MG/L 80 MG/L 400 MG/L 800 MG/L
____________________________________________________________________________________________________________________________________
None
____________________________________________________________________________________________________________________________________
MUSCULOSKELETAL SYSTEM
None
____________________________________________________________________________________________________________________________________
NERVOUS SYSTEM
None
____________________________________________________________________________________________________________________________________
RESPIRATORY SYSTEM
Lung (10) (10) (10) (10)
Hemorrhage 1 [1.0]
Inflammation, Chronic Active 1 [1.0]
____________________________________________________________________________________________________________________________________
SPECIAL SENSES SYSTEM
None
____________________________________________________________________________________________________________________________________
URINARY SYSTEM
Kidney (10) (10) (9) (10)
Infarct 1 [2.0]
Mineralization 1 [1.0]
Nephropathy 9 [1.2] 7 [1.0] 7 [1.0] 7 [1.1]
Cortex, Mineralization 1 [1.0]
Papilla, Mineralization 1 [1.0] 1 [1.0]
Pelvis, Dilatation 1 [2.0]
a Number of animals examined microscopically at site and number of animals with lesion
b Average severity grade (1-minimal;2-mild;3-moderate;4-marked)
Page 7
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