TDMS Study 97013-94 Pathology Tables
NTP Experiment-Test: 97013-94 INCIDENCE RATES OF NONNEOPLASTIC LESIONS BY ANATOMIC SITE (a) Report: PEIRPT03 Study Type: 26-39 WEEKS WATER DISINFECTION MODEL (SODIUM BROMATE) Date: 12/08/03 Route: DOSED WATER Time: 14:40:44 FINAL#1 MICE Facility: Battelle Columbus Laboratory Chemical CAS #: 7789-38-0 Lock Date: 07/30/01 Cage Range: All Reasons For Removal: All Removal Date Range: All Treatment Groups: Include All a Number of animals examined microscopically at site and number of animals with lesion Page 1 NTP Experiment-Test: 97013-94 INCIDENCE RATES OF NONNEOPLASTIC LESIONS BY ANATOMIC SITE (a) Report: PEIRPT03 Study Type: 26-39 WEEKS WATER DISINFECTION MODEL (SODIUM BROMATE) Date: 12/08/03 Route: DOSED WATER Time: 14:40:44 ____________________________________________________________________________________________________________________________________ TGAC (FVB/N) HEMIZYGOUS FEMALE 0 MG/L 80 MG/L 400 MG/L 800 MG/L ____________________________________________________________________________________________________________________________________ DISPOSITION SUMMARY Animals Initially In Study 10 10 10 10 Early Deaths Moribund Sacrifice 3 4 4 7 Natural Death 1 2 1 Survivors Terminal Sacrifice 7 5 4 2 Animals Examined Microscopically 10 10 10 10 ____________________________________________________________________________________________________________________________________ ALIMENTARY SYSTEM Liver (10) (10) (10) (10) Hematopoietic Cell Proliferation 3 (30%) 4 (40%) 6 (60%) 1 (10%) Inflammation, Chronic Active 10 (100%) 6 (60%) 7 (70%) 5 (50%) Mineralization 1 (10%) Hepatocyte, Fatty Change 1 (10%) Hepatocyte, Necrosis 1 (10%) 1 (10%) 1 (10%) Hepatocyte, Vacuolization Cytoplasmic 7 (70%) 4 (40%) 4 (40%) 3 (30%) Mesentery (2) Fat, Fibrosis 1 (50%) Fat, Necrosis 2 (100%) Stomach, Forestomach (10) (10) (10) (10) Epithelium, Hyperkeratosis 1 (10%) 2 (20%) 1 (10%) 7 (70%) Epithelium, Hyperplasia 5 (50%) 6 (60%) 4 (40%) 8 (80%) ____________________________________________________________________________________________________________________________________ CARDIOVASCULAR SYSTEM None ____________________________________________________________________________________________________________________________________ ENDOCRINE SYSTEM Adrenal Cortex (10) (10) (10) (10) Accessory Adrenal Cortical Nodule 1 (10%) 1 (10%) Mineralization 1 (10%) 2 (20%) Subcapsular, Hyperplasia 5 (50%) 6 (60%) 1 (10%) Parathyroid Gland (1) Necrosis 1 (100%) Pituitary Gland (10) (10) (9) (10) Pars Distalis, Cyst 3 (30%) 2 (20%) a Number of animals examined microscopically at site and number of animals with lesion Page 2 NTP Experiment-Test: 97013-94 INCIDENCE RATES OF NONNEOPLASTIC LESIONS BY ANATOMIC SITE (a) Report: PEIRPT03 Study Type: 26-39 WEEKS WATER DISINFECTION MODEL (SODIUM BROMATE) Date: 12/08/03 Route: DOSED WATER Time: 14:40:44 ____________________________________________________________________________________________________________________________________ TGAC (FVB/N) HEMIZYGOUS FEMALE 0 MG/L 80 MG/L 400 MG/L 800 MG/L ____________________________________________________________________________________________________________________________________ ENDOCRINE SYSTEM - CONT Pars Distalis, Hypertrophy 2 (22%) 6 (60%) Pars Distalis, Mineralization 1 (10%) Thyroid Gland (10) (9) (10) (10) Infiltration Cellular, Lymphocyte 2 (22%) 7 (70%) 8 (80%) Follicle, Degeneration 1 (11%) Follicle, Depletion Secretory 1 (10%) 8 (89%) 9 (90%) 10 (100%) Follicular Cell, Hypertrophy 8 (89%) 10 (100%) 10 (100%) ____________________________________________________________________________________________________________________________________ GENERAL BODY SYSTEM None ____________________________________________________________________________________________________________________________________ GENITAL SYSTEM Ovary (10) (9) (10) (10) Atrophy 1 (10%) 1 (10%) 2 (20%) Cyst 1 (10%) 1 (11%) Inflammation, Chronic Active 1 (10%) 3 (33%) 1 (10%) Uterus (10) (10) (10) (10) Inflammation, Suppurative 3 (30%) Endometrium, Hyperplasia, Cystic 8 (80%) 7 (70%) 5 (50%) 2 (20%) ____________________________________________________________________________________________________________________________________ HEMATOPOIETIC SYSTEM Lymph Node (1) (2) Mediastinal, Hyperplasia, Lymphoid 1 (50%) Lymph Node, Mandibular (9) (10) (10) (9) Hyperplasia, Lymphoid 2 (22%) 4 (40%) 2 (20%) 2 (22%) Inflammation, Chronic Active 1 (10%) Lymph Node, Mesenteric (9) (9) (10) (10) Hyperplasia, Lymphoid 1 (11%) Infiltration Cellular, Polymorphonuclear 1 (11%) Spleen (10) (10) (10) (10) Atrophy 1 (10%) Hematopoietic Cell Proliferation 3 (30%) 3 (30%) 6 (60%) 4 (40%) Thymus (10) (10) (10) (10) Atrophy 2 (20%) 5 (50%) 6 (60%) 9 (90%) Cyst 1 (10%) 1 (10%) ____________________________________________________________________________________________________________________________________ a Number of animals examined microscopically at site and number of animals with lesion Page 3 NTP Experiment-Test: 97013-94 INCIDENCE RATES OF NONNEOPLASTIC LESIONS BY ANATOMIC SITE (a) Report: PEIRPT03 Study Type: 26-39 WEEKS WATER DISINFECTION MODEL (SODIUM BROMATE) Date: 12/08/03 Route: DOSED WATER Time: 14:40:44 ____________________________________________________________________________________________________________________________________ TGAC (FVB/N) HEMIZYGOUS FEMALE 0 MG/L 80 MG/L 400 MG/L 800 MG/L ____________________________________________________________________________________________________________________________________ INTEGUMENTARY SYSTEM Skin (6) (8) (8) (4) Inflammation, Chronic Active 1 (17%) 1 (13%) Epidermis, Hyperplasia, Focal 5 (83%) 3 (38%) 2 (25%) 3 (75%) ____________________________________________________________________________________________________________________________________ MUSCULOSKELETAL SYSTEM None ____________________________________________________________________________________________________________________________________ NERVOUS SYSTEM None ____________________________________________________________________________________________________________________________________ RESPIRATORY SYSTEM Lung (10) (10) (10) (10) Alveolar Epithelium, Hyperplasia 1 (10%) ____________________________________________________________________________________________________________________________________ SPECIAL SENSES SYSTEM None ____________________________________________________________________________________________________________________________________ URINARY SYSTEM Kidney (10) (10) (10) (10) Mineralization 1 (10%) 2 (20%) Nephropathy 6 (60%) 6 (60%) 8 (80%) 8 (80%) Cortex, Cyst 2 (20%) Glomerulus, Inflammation, Membranoproliferative 1 (10%) 2 (20%) 1 (10%) Renal Tubule, Degeneration 7 (70%) Renal Tubule, Hypertrophy 2 (20%) 5 (50%) a Number of animals examined microscopically at site and number of animals with lesion Page 4 NTP Experiment-Test: 97013-94 INCIDENCE RATES OF NONNEOPLASTIC LESIONS BY ANATOMIC SITE (a) Report: PEIRPT03 Study Type: 26-39 WEEKS WATER DISINFECTION MODEL (SODIUM BROMATE) Date: 12/08/03 Route: DOSED WATER Time: 14:40:44 ____________________________________________________________________________________________________________________________________ TGAC (FVB/N) HEMIZYGOUS MALE 0 MG/L 80 MG/L 400 MG/L 800 MG/L ____________________________________________________________________________________________________________________________________ DISPOSITION SUMMARY Animals Initially In Study 10 10 10 10 Early Deaths Moribund Sacrifice 2 2 4 3 Natural Death 2 1 3 Survivors Terminal Sacrifice 6 7 6 4 Animals Examined Microscopically 10 10 10 10 ____________________________________________________________________________________________________________________________________ ALIMENTARY SYSTEM Liver (10) (10) (10) (10) Hematopoietic Cell Proliferation 1 (10%) 2 (20%) 1 (10%) Inflammation, Chronic Active 5 (50%) 5 (50%) 7 (70%) 4 (40%) Hepatocyte, Fatty Change 2 (20%) 1 (10%) Hepatocyte, Necrosis 1 (10%) Hepatocyte, Vacuolization Cytoplasmic 5 (50%) 6 (60%) 6 (60%) 3 (30%) Stomach, Forestomach (10) (10) (10) (10) Epithelium, Hyperkeratosis 2 (20%) 2 (20%) 1 (10%) 2 (20%) Epithelium, Hyperplasia 4 (40%) 2 (20%) 3 (30%) 5 (50%) Epithelium, Hyperplasia, Focal 1 (10%) ____________________________________________________________________________________________________________________________________ CARDIOVASCULAR SYSTEM None ____________________________________________________________________________________________________________________________________ ENDOCRINE SYSTEM Adrenal Cortex (10) (10) (10) (10) Hypertrophy 5 (50%) 7 (70%) 6 (60%) 1 (10%) Pituitary Gland (10) (10) (10) (10) Pars Distalis, Cyst 1 (10%) Pars Distalis, Hypertrophy 2 (20%) Thyroid Gland (10) (10) (10) (9) Infiltration Cellular, Lymphocyte 4 (44%) Follicle, Cyst 1 (10%) Follicle, Depletion Secretory 3 (30%) 4 (40%) 4 (40%) 7 (78%) Follicular Cell, Hypertrophy 6 (60%) 8 (80%) 8 (89%) ____________________________________________________________________________________________________________________________________ a Number of animals examined microscopically at site and number of animals with lesion Page 5 NTP Experiment-Test: 97013-94 INCIDENCE RATES OF NONNEOPLASTIC LESIONS BY ANATOMIC SITE (a) Report: PEIRPT03 Study Type: 26-39 WEEKS WATER DISINFECTION MODEL (SODIUM BROMATE) Date: 12/08/03 Route: DOSED WATER Time: 14:40:44 ____________________________________________________________________________________________________________________________________ TGAC (FVB/N) HEMIZYGOUS MALE 0 MG/L 80 MG/L 400 MG/L 800 MG/L ____________________________________________________________________________________________________________________________________ GENERAL BODY SYSTEM None ____________________________________________________________________________________________________________________________________ GENITAL SYSTEM Epididymis (10) (10) (10) (10) Cyst 1 (10%) Degeneration 1 (10%) 1 (10%) 7 (70%) Granuloma Sperm 1 (10%) Inflammation, Chronic Active 1 (10%) Preputial Gland (2) (3) (1) Atrophy 1 (50%) 1 (33%) Duct, Ectasia 2 (100%) 2 (67%) 1 (100%) Testes (10) (10) (10) (10) Mineralization 1 (10%) Bilateral, Germinal Epithelium, Degeneration 3 (30%) 8 (80%) Germinal Epithelium, Degeneration 1 (10%) 1 (10%) 2 (20%) Interstitial Cell, Hyperplasia 3 (30%) ____________________________________________________________________________________________________________________________________ HEMATOPOIETIC SYSTEM Lymph Node, Mandibular (9) (10) (10) (7) Hyperplasia, Lymphoid 2 (22%) 4 (40%) 1 (14%) Lymph Node, Mesenteric (9) (10) (10) (9) Hyperplasia, Lymphoid 1 (10%) Spleen (10) (10) (10) (10) Atrophy 1 (10%) Hematopoietic Cell Proliferation 1 (10%) 2 (20%) Thymus (10) (10) (9) (9) Atrophy 5 (50%) 1 (10%) 3 (33%) 6 (67%) Cyst 3 (30%) 1 (10%) 1 (11%) ____________________________________________________________________________________________________________________________________ INTEGUMENTARY SYSTEM Skin (9) (9) (9) (8) Inflammation, Chronic Active 1 (11%) 1 (11%) Epidermis, Hyperplasia, Focal 3 (33%) 4 (44%) 3 (33%) 1 (13%) Hair Follicle, Sebaceous Gland, Atrophy 1 (11%) ____________________________________________________________________________________________________________________________________ a Number of animals examined microscopically at site and number of animals with lesion Page 6 NTP Experiment-Test: 97013-94 INCIDENCE RATES OF NONNEOPLASTIC LESIONS BY ANATOMIC SITE (a) Report: PEIRPT03 Study Type: 26-39 WEEKS WATER DISINFECTION MODEL (SODIUM BROMATE) Date: 12/08/03 Route: DOSED WATER Time: 14:40:44 ____________________________________________________________________________________________________________________________________ TGAC (FVB/N) HEMIZYGOUS MALE 0 MG/L 80 MG/L 400 MG/L 800 MG/L ____________________________________________________________________________________________________________________________________ MUSCULOSKELETAL SYSTEM None ____________________________________________________________________________________________________________________________________ NERVOUS SYSTEM None ____________________________________________________________________________________________________________________________________ RESPIRATORY SYSTEM Lung (10) (10) (10) (10) Inflammation, Chronic Active 1 (10%) 1 (10%) Thrombosis 1 (10%) Alveolar Epithelium, Hyperplasia 1 (10%) Alveolus, Infiltration Cellular, Histiocyte 1 (10%) Perivascular, Infiltration Cellular, Lymphocyte 1 (10%) ____________________________________________________________________________________________________________________________________ SPECIAL SENSES SYSTEM None ____________________________________________________________________________________________________________________________________ URINARY SYSTEM Kidney (10) (10) (10) (10) Hydronephrosis 2 (20%) Inflammation 1 (10%) Mineralization 1 (10%) Nephropathy 7 (70%) 6 (60%) 7 (70%) 10 (100%) Cortex, Cyst 1 (10%) 1 (10%) Glomerulus, Inflammation, Membranoproliferative 2 (20%) 2 (20%) Renal Tubule, Degeneration 1 (10%) 8 (80%) Renal Tubule, Hypertrophy 1 (10%) 6 (60%) a Number of animals examined microscopically at site and number of animals with lesion Page 7 ------------------------------------------------------------ ---------- END OF REPORT ---------- ------------------------------------------------------------