TDMS Study 97013-94 Pathology Tables
NTP Experiment-Test: 97013-94 INCIDENCE RATES OF NEOPLASMS BY ANATOMIC SITE (SYSTEMIC LESIONS ABRIDGED) (a) Report: PEIRPT05
Study Type: 26-39 WEEKS WATER DISINFECTION MODEL (SODIUM BROMATE) Date: 12/08/03
Route: DOSED WATER Time: 14:42:00
FINAL#1 MICE
Facility: Battelle Columbus Laboratory
Chemical CAS #: 7789-38-0
Lock Date: 07/30/01
Cage Range: All
Reasons For Removal: All
Removal Date Range: All
Treatment Groups: Include All
a Number of animals examined microscopically at site and number of animals with lesion
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NTP Experiment-Test: 97013-94 INCIDENCE RATES OF NEOPLASMS BY ANATOMIC SITE (SYSTEMIC LESIONS ABRIDGED) (a) Report: PEIRPT05
Study Type: 26-39 WEEKS WATER DISINFECTION MODEL (SODIUM BROMATE) Date: 12/08/03
Route: DOSED WATER Time: 14:42:00
____________________________________________________________________________________________________________________________________
TGAC (FVB/N) HEMIZYGOUS FEMALE 0 MG/L 80 MG/L 400 MG/L 800 MG/L
____________________________________________________________________________________________________________________________________
DISPOSITION SUMMARY
Animals Initially in Study 10 10 10 10
Early Deaths
Moribund Sacrifice 3 4 4 7
Natural Death 1 2 1
Survivors
Terminal Sacrifice 7 5 4 2
Animals Examined Microscopically 10 10 10 10
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ALIMENTARY SYSTEM
Liver (10) (10) (10) (10)
Salivary Glands (1) (1) (2) (2)
Carcinoma 1 (100%) 2 (100%) 2 (100%)
Carcinoma, Metastatic, Zymbal's Gland 1 (100%)
Stomach, Forestomach (10) (10) (10) (10)
Squamous Cell Papilloma 2 (20%) 3 (30%)
Squamous Cell Papilloma, Multiple 1 (10%) 2 (20%) 1 (10%)
Tooth (3) (5) (2) (5)
Odontogenic Tumor 2 (67%) 4 (80%) 1 (50%) 5 (100%)
Odontogenic Tumor, Multiple 1 (33%) 1 (20%) 1 (50%)
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CARDIOVASCULAR SYSTEM
None
____________________________________________________________________________________________________________________________________
ENDOCRINE SYSTEM
Adrenal Cortex (10) (10) (10) (10)
Adrenal Medulla (10) (10) (10) (10)
Pituitary Gland (10) (10) (9) (10)
____________________________________________________________________________________________________________________________________
GENERAL BODY SYSTEM
None
____________________________________________________________________________________________________________________________________
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NTP Experiment-Test: 97013-94 INCIDENCE RATES OF NEOPLASMS BY ANATOMIC SITE (SYSTEMIC LESIONS ABRIDGED) (a) Report: PEIRPT05
Study Type: 26-39 WEEKS WATER DISINFECTION MODEL (SODIUM BROMATE) Date: 12/08/03
Route: DOSED WATER Time: 14:42:00
____________________________________________________________________________________________________________________________________
TGAC (FVB/N) HEMIZYGOUS FEMALE 0 MG/L 80 MG/L 400 MG/L 800 MG/L
____________________________________________________________________________________________________________________________________
GENITAL SYSTEM
Ovary (10) (9) (10) (10)
Luteoma 1 (10%) 1 (10%)
Uterus (10) (10) (10) (10)
____________________________________________________________________________________________________________________________________
HEMATOPOIETIC SYSTEM
Lymph Node (1) (2)
Lymph Node, Mandibular (9) (10) (10) (9)
Carcinoma, Metastatic, Uncertain Primary Site 1 (11%)
Carcinoma, Metastatic, Zymbal's Gland 1 (10%)
Lymph Node, Mesenteric (9) (9) (10) (10)
Spleen (10) (10) (10) (10)
Thymus (10) (10) (10) (10)
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INTEGUMENTARY SYSTEM
Mammary Gland (1)
Adenocarcinoma 1 (100%)
Skin (6) (8) (8) (4)
Squamous Cell Papilloma 2 (33%) 3 (38%) 3 (38%)
Squamous Cell Papilloma, Multiple 3 (50%) 5 (63%) 4 (50%) 1 (25%)
Subcutaneous Tissue, Fibrosarcoma 1 (13%)
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MUSCULOSKELETAL SYSTEM
None
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NERVOUS SYSTEM
None
____________________________________________________________________________________________________________________________________
RESPIRATORY SYSTEM
Lung (10) (10) (10) (10)
Alveolar/Bronchiolar Adenoma 1 (10%) 1 (10%) 1 (10%)
Carcinoma, Metastatic, Zymbal's Gland 1 (10%)
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NTP Experiment-Test: 97013-94 INCIDENCE RATES OF NEOPLASMS BY ANATOMIC SITE (SYSTEMIC LESIONS ABRIDGED) (a) Report: PEIRPT05
Study Type: 26-39 WEEKS WATER DISINFECTION MODEL (SODIUM BROMATE) Date: 12/08/03
Route: DOSED WATER Time: 14:42:00
____________________________________________________________________________________________________________________________________
TGAC (FVB/N) HEMIZYGOUS FEMALE 0 MG/L 80 MG/L 400 MG/L 800 MG/L
____________________________________________________________________________________________________________________________________
SPECIAL SENSES SYSTEM
Zymbal's Gland (1) (1)
Carcinoma 1 (100%)
____________________________________________________________________________________________________________________________________
URINARY SYSTEM
Kidney (10) (10) (10) (10)
____________________________________________________________________________________________________________________________________
SYSTEMIC LESIONS
Multiple Organs *(10) *(10) *(10) *(10)
Leukemia Erythrocytic 2 (20%) 2 (20%) 1 (10%)
Lymphoma Malignant 1 (10%)
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* Number of animals with any tissue examined microscopically
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NTP Experiment-Test: 97013-94 INCIDENCE RATES OF NEOPLASMS BY ANATOMIC SITE (SYSTEMIC LESIONS ABRIDGED) (a) Report: PEIRPT05
Study Type: 26-39 WEEKS WATER DISINFECTION MODEL (SODIUM BROMATE) Date: 12/08/03
Route: DOSED WATER Time: 14:42:00
____________________________________________________________________________________________________________________________________
TGAC (FVB/N) HEMIZYGOUS FEMALE 0 MG/L 80 MG/L 400 MG/L 800 MG/L
____________________________________________________________________________________________________________________________________
TUMOR SUMMARY
Total Animals with Primary Neoplasms (b) 8 9 9 8
Total Primary Neoplasms 12 23 19 10
Total Animals with Benign Neoplasms 6 8 8 2
Total Benign Neoplasms 8 13 12 2
Total Animals with Malignant Neoplasms 1 5 5 3
Total Malignant Neoplasms 1 5 5 3
Total Animals with Metastatic Neoplasms 1 1
Total Metastatic Neoplasm 1 3
Total Animals with Malignant Neoplasms 1
Uncertain Primary Site
Total Animals with Neoplasms Uncertain-
Benign or Malignant 3 5 2 5
Total Uncertain Neoplasms 3 5 2 5
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a Number of animals examined microscopically at site and number of animals with lesion
b Primary tumors: all tumors except metastatic tumors
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NTP Experiment-Test: 97013-94 INCIDENCE RATES OF NEOPLASMS BY ANATOMIC SITE (SYSTEMIC LESIONS ABRIDGED) (a) Report: PEIRPT05
Study Type: 26-39 WEEKS WATER DISINFECTION MODEL (SODIUM BROMATE) Date: 12/08/03
Route: DOSED WATER Time: 14:42:00
____________________________________________________________________________________________________________________________________
TGAC (FVB/N) HEMIZYGOUS MALE 0 MG/L 80 MG/L 400 MG/L 800 MG/L
____________________________________________________________________________________________________________________________________
DISPOSITION SUMMARY
Animals Initially in Study 10 10 10 10
Early Deaths
Moribund Sacrifice 2 2 4 3
Natural Death 2 1 3
Survivors
Terminal Sacrifice 6 7 6 4
Animals Examined Microscopically 10 10 10 10
____________________________________________________________________________________________________________________________________
ALIMENTARY SYSTEM
Liver (10) (10) (10) (10)
Salivary Glands (1)
Carcinoma 1 (100%)
Stomach, Forestomach (10) (10) (10) (10)
Squamous Cell Papilloma 2 (20%) 3 (30%) 1 (10%) 1 (10%)
Squamous Cell Papilloma, Multiple 2 (20%) 1 (10%)
Tooth (3) (2) (4) (2)
Odontogenic Tumor 3 (100%) 2 (100%) 3 (75%) 2 (100%)
Odontogenic Tumor, Multiple 1 (25%)
____________________________________________________________________________________________________________________________________
CARDIOVASCULAR SYSTEM
None
____________________________________________________________________________________________________________________________________
ENDOCRINE SYSTEM
Adrenal Cortex (10) (10) (10) (10)
Adrenal Medulla (10) (10) (10) (10)
Pituitary Gland (10) (10) (10) (10)
____________________________________________________________________________________________________________________________________
GENERAL BODY SYSTEM
None
____________________________________________________________________________________________________________________________________
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NTP Experiment-Test: 97013-94 INCIDENCE RATES OF NEOPLASMS BY ANATOMIC SITE (SYSTEMIC LESIONS ABRIDGED) (a) Report: PEIRPT05
Study Type: 26-39 WEEKS WATER DISINFECTION MODEL (SODIUM BROMATE) Date: 12/08/03
Route: DOSED WATER Time: 14:42:00
____________________________________________________________________________________________________________________________________
TGAC (FVB/N) HEMIZYGOUS MALE 0 MG/L 80 MG/L 400 MG/L 800 MG/L
____________________________________________________________________________________________________________________________________
GENITAL SYSTEM
Epididymis (10) (10) (10) (10)
____________________________________________________________________________________________________________________________________
HEMATOPOIETIC SYSTEM
Lymph Node (1)
Lymph Node, Mandibular (9) (10) (10) (7)
Spleen (10) (10) (10) (10)
____________________________________________________________________________________________________________________________________
INTEGUMENTARY SYSTEM
Skin (9) (9) (9) (8)
Squamous Cell Papilloma 2 (22%) 1 (11%) 3 (38%)
Squamous Cell Papilloma, Multiple 5 (56%) 6 (67%) 5 (56%) 4 (50%)
____________________________________________________________________________________________________________________________________
MUSCULOSKELETAL SYSTEM
None
____________________________________________________________________________________________________________________________________
NERVOUS SYSTEM
None
____________________________________________________________________________________________________________________________________
RESPIRATORY SYSTEM
Lung (10) (10) (10) (10)
Alveolar/Bronchiolar Adenoma 1 (10%) 3 (30%) 1 (10%)
Trachea (1)
Adenoma 1 (100%)
____________________________________________________________________________________________________________________________________
SPECIAL SENSES SYSTEM
None
____________________________________________________________________________________________________________________________________
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NTP Experiment-Test: 97013-94 INCIDENCE RATES OF NEOPLASMS BY ANATOMIC SITE (SYSTEMIC LESIONS ABRIDGED) (a) Report: PEIRPT05
Study Type: 26-39 WEEKS WATER DISINFECTION MODEL (SODIUM BROMATE) Date: 12/08/03
Route: DOSED WATER Time: 14:42:00
____________________________________________________________________________________________________________________________________
TGAC (FVB/N) HEMIZYGOUS MALE 0 MG/L 80 MG/L 400 MG/L 800 MG/L
____________________________________________________________________________________________________________________________________
URINARY SYSTEM
Kidney (10) (10) (10) (10)
____________________________________________________________________________________________________________________________________
SYSTEMIC LESIONS
Multiple Organs *(10) *(10) *(10) *(10)
Leukemia Erythrocytic 2 (20%) 2 (20%) 2 (20%)
Lymphoma Malignant 1 (10%)
____________________________________________________________________________________________________________________________________
* Number of animals with any tissue examined microscopically
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NTP Experiment-Test: 97013-94 INCIDENCE RATES OF NEOPLASMS BY ANATOMIC SITE (SYSTEMIC LESIONS ABRIDGED) (a) Report: PEIRPT05
Study Type: 26-39 WEEKS WATER DISINFECTION MODEL (SODIUM BROMATE) Date: 12/08/03
Route: DOSED WATER Time: 14:42:00
____________________________________________________________________________________________________________________________________
TGAC (FVB/N) HEMIZYGOUS MALE 0 MG/L 80 MG/L 400 MG/L 800 MG/L
____________________________________________________________________________________________________________________________________
TUMOR SUMMARY
Total Animals with Primary Neoplasms (b) 10 9 10 9
Total Primary Neoplasms 15 19 14 13
Total Animals with Benign Neoplasms 7 8 7 8
Total Benign Neoplasms 10 15 8 9
Total Animals with Malignant Neoplasms 2 2 2 2
Total Malignant Neoplasms 2 2 2 2
Total Animals with Metastatic Neoplasms
Total Metastatic Neoplasm
Total Animals with Malignant Neoplasms
Uncertain Primary Site
Total Animals with Neoplasms Uncertain-
Benign or Malignant 3 2 4 2
Total Uncertain Neoplasms 3 2 4 2
____________________________________________________________________________________________________________________________________
a Number of animals examined microscopically at site and number of animals with lesion
b Primary tumors: all tumors except metastatic tumors
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