TDMS Study 97013-94 Pathology Tables
NTP STATISTICAL ANALYSIS OF SURVIVAL DATA REPORT: PEIRPT11
LAB: Battelle Columbus WATER DISINFECTION MODEL (SODIUM BROMATE) DATE: 12/08/03
EXPERIMENT: 97013 TEST: 94 TIME: 14:45:00
TEST TYPE: 26-39 WEEKS CAGES FROM 0000 TO LAST CAGE PAGE: 1
CONT: N01-ES-65406 ROUTE: DOSED WATER NTP C#: 97013H
PATHOLOGIST: MISSING CAS: 7789-38-0
------------------------------------------------------------------------------------------------------------------------------------
FINAL#1 MICE
REASONS FOR REMOVAL: ALL
REMOVAL DATE RANGE: ALL
TREATMENT GROUPS: INCLUDE ALL
NTP STATISTICAL ANALYSIS OF SURVIVAL DATA REPORT: PEIRPT11
LAB: Battelle Columbus WATER DISINFECTION MODEL (SODIUM BROMATE) DATE: 12/08/03
EXPERIMENT: 97013 TEST: 94 TIME: 14:45:00
TEST TYPE: 26-39 WEEKS CAGES FROM 0000 TO LAST CAGE
CONT: N01-ES-65406 ROUTE: DOSED WATER NTP C#: 97013H
PATHOLOGIST: MISSING CAS: 7789-38-0
WATER DISINFECTION MODEL (SODIUM BROMATE)
STATISTICAL ANALYSIS OF SURVIVAL DATA
MALE MICE
FIRST TERMINAL SACRIFICE AT 295 DAYS
INDIVIDUAL SURVIVAL TIMES (DAYS)
==================================================================================
| DOSE = 0 MG/L |
| --------------------- |
| |
| TOTAL 10 UNCENSORED DEATHS 4 CENSORED DEATHS 0 TERMINAL 6 |
| |
| UNCENSORED DEATHS |
| 93 185 224 239 |
| CENSORED DEATHS |
| NONE |
| |
|--------------------------------------------------------------------------------|
| DOSE = 80 MG/L |
| --------------------- |
| |
| TOTAL 10 UNCENSORED DEATHS 3 CENSORED DEATHS 0 TERMINAL 7 |
| |
| UNCENSORED DEATHS |
| 89 93 192 |
| CENSORED DEATHS |
| NONE |
| |
|--------------------------------------------------------------------------------|
| DOSE = 400 MG/L |
| --------------------- |
| |
| TOTAL 10 UNCENSORED DEATHS 4 CENSORED DEATHS 0 TERMINAL 6 |
| |
| UNCENSORED DEATHS |
| 144 188 246 277 |
| CENSORED DEATHS |
| NONE |
| |
==================================================================================
WATER DISINFECTION MODEL (SODIUM BROMATE)
STATISTICAL ANALYSIS OF SURVIVAL DATA
MALE MICE
FIRST TERMINAL SACRIFICE AT 295 DAYS
INDIVIDUAL SURVIVAL TIMES (DAYS)
==================================================================================
| DOSE = 800 MG/L |
| --------------------- |
| |
| TOTAL 10 UNCENSORED DEATHS 6 CENSORED DEATHS 0 TERMINAL 4 |
| |
| UNCENSORED DEATHS |
| 127 218 246 263 277 284 |
| CENSORED DEATHS |
| NONE |
| |
==================================================================================
WATER DISINFECTION MODEL (SODIUM BROMATE)
STATISTICAL ANALYSIS OF SURVIVAL DATA
MALE MICE
FIRST TERMINAL SACRIFICE AT 295 DAYS
==================================================================================
| KAPLAN-MEIER SURVIVAL PROBABILITY ESTIMATES (%) |
| |
|--------------------------------------------------------------------------------|
| DOSE TIME (DAYS) |
| 30 60 90 120 150 180 210 240 270 295 (A) |
| |
|--------------------------------------------------------------------------------|
| | |
|0 MG/L | 100.0 100.0 100.0 90.0 90.0 90.0 80.0 70.0 60.0 60.0 |
| | |
| | |
|80 MG/L | 100.0 100.0 100.0 80.0 80.0 80.0 70.0 70.0 70.0 70.0 |
| | |
| | |
|400 MG/L | 100.0 100.0 100.0 100.0 90.0 90.0 80.0 80.0 70.0 60.0 |
| | |
| | |
|800 MG/L | 100.0 100.0 100.0 100.0 90.0 90.0 90.0 80.0 60.0 40.0 |
| | |
| | |
==================================================================================
==================================================================================
| SURVIVAL SUMMARY STATISTICS |
| |
| |
|--------------------------------------------------------------------------------|
| DOSE |
| |
| 0 MG/L 80 MG/L 400 MG/L 800 MG/L |
| |
|--------------------------------------------------------------------------------|
|SURVIVAL AT END OF STUDY| 60.0% 70.0% 60.0% 40.0% |
|(KAPLAN-MEIER) | |
| | |
|SIGNIFICANCE (B) | P=0.515 P=1.000N P=1.000N P=0.826 |
|(LIFE TABLE) | |
| | |
|MEAN DAY OF | 185.3 124.7 213.8 235.8 |
|NATURAL DEATHS (C) | (32.8) (33.7) (29.7) (23.8) |
|(STANDARD ERROR) | |
| | |
|MEAN LIFE SPAN (D) | 251.1 243.9 262.5 259.5 |
|(STANDARD ERROR) | (21.6) (27.4) (17.1) (16.8) |
| | |
==================================================================================
(A) FIRST TERMINAL SACRIFICE
(B) THE FIRST ENTRY IS THE TREND TEST (TARONE, 1975) RESULT.
SUBSEQUENT ENTRIES ARE THE RESULTS OF PAIRWISE TESTS
(COX,1972). NEGATIVE TRENDS ARE INDICATED BY "N".
(C) MEAN OF ALL UNCENSORED DEATHS PRIOR TO TERMINAL SACRIFICE
(D) MEAN OF ALL DEATHS (UNCENSORED, CENSORED, TERMINAL SACRIFICE)
WATER DISINFECTION MODEL (SODIUM BROMATE)
STATISTICAL ANALYSIS OF SURVIVAL DATA
FEMALE MICE
FIRST TERMINAL SACRIFICE AT 295 DAYS
INDIVIDUAL SURVIVAL TIMES (DAYS)
==================================================================================
| DOSE = 0 MG/L |
| --------------------- |
| |
| TOTAL 10 UNCENSORED DEATHS 3 CENSORED DEATHS 0 TERMINAL 7 |
| |
| UNCENSORED DEATHS |
| 57 93 246 |
| CENSORED DEATHS |
| NONE |
| |
|--------------------------------------------------------------------------------|
| DOSE = 80 MG/L |
| --------------------- |
| |
| TOTAL 10 UNCENSORED DEATHS 5 CENSORED DEATHS 0 TERMINAL 5 |
| |
| UNCENSORED DEATHS |
| 42 144 255 287 287 |
| CENSORED DEATHS |
| NONE |
| |
|--------------------------------------------------------------------------------|
| DOSE = 400 MG/L |
| --------------------- |
| |
| TOTAL 10 UNCENSORED DEATHS 6 CENSORED DEATHS 0 TERMINAL 4 |
| |
| UNCENSORED DEATHS |
| 115 144 173 197 287 287 |
| CENSORED DEATHS |
| NONE |
| |
==================================================================================
WATER DISINFECTION MODEL (SODIUM BROMATE)
STATISTICAL ANALYSIS OF SURVIVAL DATA
FEMALE MICE
FIRST TERMINAL SACRIFICE AT 295 DAYS
INDIVIDUAL SURVIVAL TIMES (DAYS)
==================================================================================
| DOSE = 800 MG/L |
| --------------------- |
| |
| TOTAL 10 UNCENSORED DEATHS 8 CENSORED DEATHS 0 TERMINAL 2 |
| |
| UNCENSORED DEATHS |
| 8 93 115 188 197 199 273 277 |
| CENSORED DEATHS |
| NONE |
| |
==================================================================================
WATER DISINFECTION MODEL (SODIUM BROMATE)
STATISTICAL ANALYSIS OF SURVIVAL DATA
FEMALE MICE
FIRST TERMINAL SACRIFICE AT 295 DAYS
==================================================================================
| KAPLAN-MEIER SURVIVAL PROBABILITY ESTIMATES (%) |
| |
|--------------------------------------------------------------------------------|
| DOSE TIME (DAYS) |
| 30 60 90 120 150 180 210 240 270 295 (A) |
| |
|--------------------------------------------------------------------------------|
| | |
|0 MG/L | 100.0 90.0 90.0 80.0 80.0 80.0 80.0 80.0 70.0 70.0 |
| | |
| | |
|80 MG/L | 100.0 90.0 90.0 90.0 80.0 80.0 80.0 80.0 70.0 50.0 |
| | |
| | |
|400 MG/L | 100.0 100.0 100.0 90.0 80.0 70.0 60.0 60.0 60.0 40.0 |
| | |
| | |
|800 MG/L | 90.0 90.0 90.0 70.0 70.0 70.0 40.0 40.0 40.0 20.0 |
| | |
| | |
==================================================================================
==================================================================================
| SURVIVAL SUMMARY STATISTICS |
| |
| |
|--------------------------------------------------------------------------------|
| DOSE |
| |
| 0 MG/L 80 MG/L 400 MG/L 800 MG/L |
| |
|--------------------------------------------------------------------------------|
|SURVIVAL AT END OF STUDY| 70.0% 50.0% 40.0% 20.0% |
|(KAPLAN-MEIER) | |
| | |
|SIGNIFICANCE (B) | P=0.030 P=0.740 P=0.470 P=0.089 |
|(LIFE TABLE) | |
| | |
|MEAN DAY OF | 132.0 203.0 200.5 168.8 |
|NATURAL DEATHS (C) | (57.9) (48.1) (29.6) (32.5) |
|(STANDARD ERROR) | |
| | |
|MEAN LIFE SPAN (D) | 246.1 249.0 238.3 194.0 |
|(STANDARD ERROR) | (29.0) (27.4) (23.0) (30.7) |
| | |
==================================================================================
(A) FIRST TERMINAL SACRIFICE
(B) THE FIRST ENTRY IS THE TREND TEST (TARONE, 1975) RESULT.
SUBSEQUENT ENTRIES ARE THE RESULTS OF PAIRWISE TESTS
(COX,1972). NEGATIVE TRENDS ARE INDICATED BY "N".
(C) MEAN OF ALL UNCENSORED DEATHS PRIOR TO TERMINAL SACRIFICE
(D) MEAN OF ALL DEATHS (UNCENSORED, CENSORED, TERMINAL SACRIFICE)
WATER DISINFECTION MODEL (SODIUM BROMATE)
KAPLAN-MEIER SURVIVAL CURVES
0 MG/L = 1
80 MG/L = 2
400 MG/L = 3
800 MG/L = 4
------------------------------------------------------ SPECIES=MICE SEX=MALE -------------------------------------------------------
Plot of SURVIVAL*WEEK. Symbol is value of DOSE.
|
|
100 + 1 2 1 4 3
|
|
|
P 90 + 2 1 4 3 1 4
E |
R |
C |
E 80 + 2 1 2 1 3
N |
T |
|
S 70 + 2 1 1 3 4 3 2
U |
R |
V |
I 60 + 1 4 3 1
V |
A |
L |
50 + 4 4
|
|
|
40 + 4 4
|
---+------------+------------+------------+------------+------------+------------+------------+------------+------------+--
0 5 10 15 20 25 30 35 40 45
WEEK
NOTE: 11 obs hidden.
WATER DISINFECTION MODEL (SODIUM BROMATE)
KAPLAN-MEIER SURVIVAL CURVES
0 MG/L = 1
80 MG/L = 2
400 MG/L = 3
800 MG/L = 4
----------------------------------------------------- SPECIES=MICE SEX=FEMALE ------------------------------------------------------
Plot of SURVIVAL*WEEK. Symbol is value of DOSE.
|
|
100 + 1 4 2 1 3
|
|
|
90 + 4 2 1 1 3 2
|
|
|
P 80 + 1 4 2 3 1 2
E |
R |
C |
E 70 + 4 3 4 3 1 2 2 1
N |
T |
|
S 60 + 4 3 3
U |
R |
V |
I 50 + 2 2
V |
A |
L |
40 + 4 4 3 3
|
|
|
30 + 4 4
|
|
|
20 + 4 4
|
---+------------+------------+------------+------------+------------+------------+------------+------------+------------+--
0 5 10 15 20 25 30 35 40 45
WEEK
NOTE: 8 obs hidden.