TDMS Study 97013-95 Pathology Tables
NTP Experiment-Test: 97013-95 INCIDENCE RATES OF NONNEOPLASTIC LESIONS BY ANATOMIC SITE (a) Report: PEIRPT03
Study Type: 26-39 WEEKS WATER DISINFECTION MODEL (BROMODICHLOROMETHANE) Date: 10/08/03
Route: DOSED WATER Time: 10:07:31
FINAL/MICE
Facility: Battelle Columbus Laboratory
Chemical CAS #: 75-27-4
Lock Date: 07/19/01
Cage Range: All
Reasons For Removal: All
Removal Date Range: All
Treatment Groups: Include All
a Number of animals examined microscopically at site and number of animals with lesion
Page 1
NTP Experiment-Test: 97013-95 INCIDENCE RATES OF NONNEOPLASTIC LESIONS BY ANATOMIC SITE (a) Report: PEIRPT03
Study Type: 26-39 WEEKS WATER DISINFECTION MODEL (BROMODICHLOROMETHANE) Date: 10/08/03
Route: DOSED WATER Time: 10:07:31
____________________________________________________________________________________________________________________________________
TGAC (FVB/N) HEMIZYGOUS FEMALE 0 MG/L 175 MG/L 350 MG/L 700 MG/L
____________________________________________________________________________________________________________________________________
DISPOSITION SUMMARY
Animals Initially In Study 10 10 10 10
Early Deaths
Natural Death 2 1 1
Moribund Sacrifice 3 2 5 5
Survivors
Terminal Sacrifice 5 8 4 4
Animals Examined Microscopically 10 10 10 10
____________________________________________________________________________________________________________________________________
ALIMENTARY SYSTEM
Intestine Large, Colon (10) (10) (10) (10)
Necrosis 1 (10%)
Epithelium, Regeneration 1 (10%)
Liver (10) (10) (10) (10)
Hematopoietic Cell Proliferation 1 (10%) 3 (30%) 1 (10%) 1 (10%)
Infiltration Cellular 2 (20%)
Inflammation 5 (50%) 10 (100%) 8 (80%) 7 (70%)
Necrosis 2 (20%) 2 (20%)
Hepatocyte, Fatty Change 6 (60%) 6 (60%) 6 (60%)
Hepatocyte, Vacuolization Cytoplasmic 5 (50%) 8 (80%) 8 (80%) 8 (80%)
Mesentery (1) (1) (1)
Inflammation, Suppurative 1 (100%)
Artery, Inflammation 1 (100%) 1 (100%)
Stomach, Forestomach (10) (10) (10) (10)
Hyperkeratosis 1 (10%)
Epithelium, Hyperplasia 3 (30%) 1 (10%) 1 (10%)
____________________________________________________________________________________________________________________________________
CARDIOVASCULAR SYSTEM
None
____________________________________________________________________________________________________________________________________
ENDOCRINE SYSTEM
Adrenal Cortex (10) (10) (10) (10)
Hematopoietic Cell Proliferation 1 (10%)
Subcapsular, Hyperplasia 6 (60%) 5 (50%) 7 (70%) 8 (80%)
Pituitary Gland (10) (10) (10) (10)
Cyst 2 (20%) 3 (30%) 1 (10%) 2 (20%)
a Number of animals examined microscopically at site and number of animals with lesion
Page 2
NTP Experiment-Test: 97013-95 INCIDENCE RATES OF NONNEOPLASTIC LESIONS BY ANATOMIC SITE (a) Report: PEIRPT03
Study Type: 26-39 WEEKS WATER DISINFECTION MODEL (BROMODICHLOROMETHANE) Date: 10/08/03
Route: DOSED WATER Time: 10:07:31
____________________________________________________________________________________________________________________________________
TGAC (FVB/N) HEMIZYGOUS FEMALE 0 MG/L 175 MG/L 350 MG/L 700 MG/L
____________________________________________________________________________________________________________________________________
ENDOCRINE SYSTEM - CONT
Hyperplasia 1 (10%)
Thyroid Gland (10) (10) (10) (10)
Cyst 1 (10%) 1 (10%)
Inflammation 2 (20%) 1 (10%) 1 (10%)
____________________________________________________________________________________________________________________________________
GENERAL BODY SYSTEM
Peritoneum (1)
Inflammation 1 (100%)
____________________________________________________________________________________________________________________________________
GENITAL SYSTEM
Ovary (10) (10) (10) (10)
Atrophy 2 (20%) 2 (20%) 1 (10%) 2 (20%)
Cyst 1 (10%) 1 (10%) 1 (10%)
Inflammation 2 (20%)
Inflammation, Suppurative 2 (20%)
Oviduct (1)
Inflammation 1 (100%)
Uterus (10) (10) (10) (10)
Inflammation 1 (10%) 1 (10%)
Endometrium, Hyperplasia, Cystic 7 (70%) 9 (90%) 6 (60%) 6 (60%)
____________________________________________________________________________________________________________________________________
HEMATOPOIETIC SYSTEM
Lymph Node (2)
Mediastinal, Infiltration Cellular, Plasma
Cell 1 (50%)
Renal, Hyperplasia 1 (50%)
Lymph Node, Mandibular (10) (10) (10) (10)
Atrophy 1 (10%)
Hyperplasia 1 (10%) 2 (20%)
Infiltration Cellular, Plasma Cell 1 (10%) 1 (10%) 2 (20%)
Lymph Node, Mesenteric (10) (10) (9) (10)
Hematopoietic Cell Proliferation 1 (10%)
Spleen (10) (10) (10) (10)
Atrophy 1 (10%) 1 (10%)
Hematopoietic Cell Proliferation 3 (30%) 3 (30%) 2 (20%)
Thymus (10) (10) (10) (10)
Atrophy 4 (40%) 2 (20%) 2 (20%) 2 (20%)
a Number of animals examined microscopically at site and number of animals with lesion
Page 3
NTP Experiment-Test: 97013-95 INCIDENCE RATES OF NONNEOPLASTIC LESIONS BY ANATOMIC SITE (a) Report: PEIRPT03
Study Type: 26-39 WEEKS WATER DISINFECTION MODEL (BROMODICHLOROMETHANE) Date: 10/08/03
Route: DOSED WATER Time: 10:07:31
____________________________________________________________________________________________________________________________________
TGAC (FVB/N) HEMIZYGOUS FEMALE 0 MG/L 175 MG/L 350 MG/L 700 MG/L
____________________________________________________________________________________________________________________________________
HEMATOPOIETIC SYSTEM - CONT
Cyst 3 (30%) 3 (30%) 3 (30%) 4 (40%)
____________________________________________________________________________________________________________________________________
INTEGUMENTARY SYSTEM
Skin (8) (8) (8) (6)
Abscess 1 (13%)
Hyperkeratosis 1 (17%)
Hyperplasia, Focal 1 (17%)
Ulcer 1 (17%)
Control Epidermis, Hyperplasia 1 (13%)
Epidermis, Hyperplasia, Focal 1 (17%)
Subcutaneous Tissue, Inflammation 1 (13%)
____________________________________________________________________________________________________________________________________
MUSCULOSKELETAL SYSTEM
None
____________________________________________________________________________________________________________________________________
NERVOUS SYSTEM
None
____________________________________________________________________________________________________________________________________
RESPIRATORY SYSTEM
Lung (10) (10) (10) (10)
Inflammation 2 (20%)
Alveolar Epithelium, Hyperplasia 1 (10%) 2 (20%) 1 (10%)
Perivascular, Inflammation 1 (10%)
____________________________________________________________________________________________________________________________________
SPECIAL SENSES SYSTEM
None
____________________________________________________________________________________________________________________________________
URINARY SYSTEM
Kidney (10) (10) (10) (10)
Casts Protein 1 (10%) 2 (20%)
Cyst 1 (10%) 5 (50%) 2 (20%)
a Number of animals examined microscopically at site and number of animals with lesion
Page 4
NTP Experiment-Test: 97013-95 INCIDENCE RATES OF NONNEOPLASTIC LESIONS BY ANATOMIC SITE (a) Report: PEIRPT03
Study Type: 26-39 WEEKS WATER DISINFECTION MODEL (BROMODICHLOROMETHANE) Date: 10/08/03
Route: DOSED WATER Time: 10:07:31
____________________________________________________________________________________________________________________________________
TGAC (FVB/N) HEMIZYGOUS FEMALE 0 MG/L 175 MG/L 350 MG/L 700 MG/L
____________________________________________________________________________________________________________________________________
URINARY SYSTEM - CONT
Hydronephrosis 2 (20%)
Infarct 1 (10%)
Inflammation 1 (10%)
Mineralization 1 (10%)
Nephropathy 4 (40%) 2 (20%) 4 (40%) 2 (20%)
Glomerulus, Inflammation,
Membranoproliferative 1 (10%) 1 (10%)
Renal Tubule, Accumulation, Hyaline Droplet 1 (10%)
Renal Tubule, Hypertrophy 2 (20%) 1 (10%)
a Number of animals examined microscopically at site and number of animals with lesion
Page 5
NTP Experiment-Test: 97013-95 INCIDENCE RATES OF NONNEOPLASTIC LESIONS BY ANATOMIC SITE (a) Report: PEIRPT03
Study Type: 26-39 WEEKS WATER DISINFECTION MODEL (BROMODICHLOROMETHANE) Date: 10/08/03
Route: DOSED WATER Time: 10:07:31
____________________________________________________________________________________________________________________________________
TGAC (FVB/N) HEMIZYGOUS MALE 0 MG/L 175 MG/L 350 MG/L 700 MG/L
____________________________________________________________________________________________________________________________________
DISPOSITION SUMMARY
Animals Initially In Study 10 10 10 10
Early Deaths
Moribund Sacrifice 4 1
Natural Death 1 2
Survivors
Terminal Sacrifice 6 9 8 9
Animals Examined Microscopically 10 10 10 10
____________________________________________________________________________________________________________________________________
ALIMENTARY SYSTEM
Esophagus (1)
Inflammation 1 (100%)
Liver (10) (10) (10) (10)
Hematopoietic Cell Proliferation 1 (10%) 1 (10%) 1 (10%)
Inflammation 5 (50%) 4 (40%) 8 (80%) 7 (70%)
Necrosis 1 (10%) 1 (10%)
Hepatocyte, Fatty Change 3 (30%) 2 (20%)
Hepatocyte, Vacuolization Cytoplasmic 7 (70%) 9 (90%) 8 (80%) 8 (80%)
Mesentery (1) (1)
Fat, Necrosis 1 (100%) 1 (100%)
Stomach, Forestomach (10) (10) (10) (10)
Hyperkeratosis 1 (10%)
Epithelium, Hyperplasia 1 (10%)
____________________________________________________________________________________________________________________________________
CARDIOVASCULAR SYSTEM
None
____________________________________________________________________________________________________________________________________
ENDOCRINE SYSTEM
Adrenal Cortex (10) (10) (10) (10)
Hypertrophy 5 (50%) 4 (40%) 4 (40%) 4 (40%)
Subcapsular, Hyperplasia 1 (10%) 1 (10%) 2 (20%)
Pituitary Gland (10) (10) (10) (10)
Cyst 2 (20%) 3 (30%) 1 (10%)
Thyroid Gland (10) (10) (10) (10)
Cyst 2 (20%) 2 (20%) 1 (10%) 2 (20%)
Follicle, Cyst 1 (10%) 1 (10%)
a Number of animals examined microscopically at site and number of animals with lesion
Page 6
NTP Experiment-Test: 97013-95 INCIDENCE RATES OF NONNEOPLASTIC LESIONS BY ANATOMIC SITE (a) Report: PEIRPT03
Study Type: 26-39 WEEKS WATER DISINFECTION MODEL (BROMODICHLOROMETHANE) Date: 10/08/03
Route: DOSED WATER Time: 10:07:31
____________________________________________________________________________________________________________________________________
TGAC (FVB/N) HEMIZYGOUS MALE 0 MG/L 175 MG/L 350 MG/L 700 MG/L
____________________________________________________________________________________________________________________________________
GENERAL BODY SYSTEM
None
____________________________________________________________________________________________________________________________________
GENITAL SYSTEM
Preputial Gland (1)
Duct, Ectasia 1 (100%)
Testes (10) (10) (10) (10)
Mineralization 2 (20%)
Germinal Epithelium, Degeneration 3 (30%) 1 (10%) 1 (10%)
____________________________________________________________________________________________________________________________________
HEMATOPOIETIC SYSTEM
Lymph Node, Mandibular (10) (10) (10) (10)
Angiectasis 1 (10%)
Hyperplasia 1 (10%)
Infiltration Cellular, Plasma Cell 1 (10%) 1 (10%) 1 (10%) 2 (20%)
Spleen (10) (10) (10) (10)
Atrophy 1 (10%)
Hematopoietic Cell Proliferation 1 (10%) 1 (10%) 1 (10%)
Thymus (9) (9) (10) (10)
Atrophy 1 (11%) 1 (11%) 1 (10%)
Cyst 2 (22%) 3 (33%) 4 (40%) 5 (50%)
____________________________________________________________________________________________________________________________________
INTEGUMENTARY SYSTEM
Skin (8) (8) (8) (8)
Hyperplasia 2 (25%) 1 (13%) 1 (13%)
Inflammation 1 (13%)
Control Epidermis, Hyperplasia 2 (25%)
____________________________________________________________________________________________________________________________________
MUSCULOSKELETAL SYSTEM
None
____________________________________________________________________________________________________________________________________
NERVOUS SYSTEM
a Number of animals examined microscopically at site and number of animals with lesion
Page 7
NTP Experiment-Test: 97013-95 INCIDENCE RATES OF NONNEOPLASTIC LESIONS BY ANATOMIC SITE (a) Report: PEIRPT03
Study Type: 26-39 WEEKS WATER DISINFECTION MODEL (BROMODICHLOROMETHANE) Date: 10/08/03
Route: DOSED WATER Time: 10:07:31
____________________________________________________________________________________________________________________________________
TGAC (FVB/N) HEMIZYGOUS MALE 0 MG/L 175 MG/L 350 MG/L 700 MG/L
____________________________________________________________________________________________________________________________________
None
____________________________________________________________________________________________________________________________________
RESPIRATORY SYSTEM
Lung (10) (10) (10) (10)
Infiltration Cellular, Histiocyte 1 (10%)
Inflammation 2 (20%) 1 (10%)
Alveolar Epithelium, Hyperplasia 1 (10%) 1 (10%)
Perivascular, Inflammation 1 (10%) 3 (30%)
____________________________________________________________________________________________________________________________________
SPECIAL SENSES SYSTEM
None
____________________________________________________________________________________________________________________________________
URINARY SYSTEM
Kidney (10) (10) (10) (10)
Casts Protein 2 (20%) 1 (10%) 4 (40%)
Cyst 3 (30%) 1 (10%) 1 (10%)
Hydronephrosis 1 (10%) 2 (20%)
Infiltration Cellular, Plasma Cell 1 (10%)
Mineralization 2 (20%)
Nephropathy 4 (40%) 7 (70%) 8 (80%) 9 (90%)
Artery, Inflammation 1 (10%)
Glomerulus, Inflammation,
Membranoproliferative 1 (10%)
Renal Tubule, Degeneration 2 (20%) 6 (60%)
Renal Tubule, Dilatation 1 (10%) 8 (80%) 8 (80%) 10 (100%)
Renal Tubule, Hypertrophy 1 (10%)
Renal Tubule, Vacuolization Cytoplasmic 1 (10%)
a Number of animals examined microscopically at site and number of animals with lesion
Page 8
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