TDMS Study 96021-01 Pathology Tables
NTP Experiment-Test: 96021-01 INCIDENCE RATES OF NONNEOPLASTIC LESIONS BY ANATOMIC SITE (a) Report: PEIRPT03
Study Type: CHRONIC TOXIC EQUIVALENCY FACTOR EVALUATION (PCB 153) Date: 06/05/03
Route: GAVAGE Time: 10:34:18
14 WEEK SSAC FINAL#1
Facility: Battelle Columbus Laboratory
Chemical CAS #: 35065-27-1
Lock Date: 01/16/02
Cage Range: All
Reasons For Removal: 25017 Scheduled Sacrifice
Removal Date Range: 11/23/98 - 11/24/98
Treatment Groups: Include 001 0 UG/KG
Include 002 10 UG/KG
Include 003 100 UG/KG
Include 004 300 UG/KG
Include 005 1000 UG/KG
Include 006 3000 UG/KG
a Number of animals examined microscopically at site and number of animals with lesion
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NTP Experiment-Test: 96021-01 INCIDENCE RATES OF NONNEOPLASTIC LESIONS BY ANATOMIC SITE (a) Report: PEIRPT03
Study Type: CHRONIC TOXIC EQUIVALENCY FACTOR EVALUATION (PCB 153) Date: 06/05/03
Route: GAVAGE Time: 10:34:18
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SPRAGUE-DAWLEY RATS FEMALE 0 UG/KG 10 UG/KG 100 300 1000 3000
UG/KG UG/KG UG/KG UG/KG
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DISPOSITION SUMMARY
Animals Initially In Study 98 86 98 98 98 80
Scheduled Sacrifice 16 10 16 16 16 10
Early Deaths
Survivors
Animals Examined Microscopically 10 10 10 10 10 10
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ALIMENTARY SYSTEM
Liver (10) (10) (10) (10) (10) (10)
Inflammation 10 (100%) 10 (100%) 10 (100%) 9 (90%) 10 (100%) 10 (100%)
Mixed Cell Focus 1 (10%)
Hepatocyte, Hypertrophy 9 (90%) 10 (100%)
Pancreas (10) (10)
Inflammation, Chronic Active 1 (10%)
Acinus, Atrophy 1 (10%)
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CARDIOVASCULAR SYSTEM
None
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ENDOCRINE SYSTEM
Thyroid Gland (10) (10) (10) (10) (10) (10)
Follicular Cell, Hypertrophy 2 (20%) 3 (30%) 1 (10%) 1 (10%) 4 (40%)
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GENERAL BODY SYSTEM
None
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GENITAL SYSTEM
Ovary (10) (10)
Atrophy 1 (10%) 1 (10%)
Uterus (10) (10)
Metaplasia, Squamous 1 (10%)
a Number of animals examined microscopically at site and number of animals with lesion
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NTP Experiment-Test: 96021-01 INCIDENCE RATES OF NONNEOPLASTIC LESIONS BY ANATOMIC SITE (a) Report: PEIRPT03
Study Type: CHRONIC TOXIC EQUIVALENCY FACTOR EVALUATION (PCB 153) Date: 06/05/03
Route: GAVAGE Time: 10:34:18
____________________________________________________________________________________________________________________________________
SPRAGUE-DAWLEY RATS FEMALE 0 UG/KG 10 UG/KG 100 300 1000 3000
UG/KG UG/KG UG/KG UG/KG
____________________________________________________________________________________________________________________________________
GENITAL SYSTEM - CONT
Endometrium, Hyperplasia, Cystic 5 (50%) 2 (20%)
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HEMATOPOIETIC SYSTEM
Spleen (10) (10)
Pigmentation 10 (100%) 10 (100%)
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INTEGUMENTARY SYSTEM
None
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MUSCULOSKELETAL SYSTEM
None
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NERVOUS SYSTEM
None
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RESPIRATORY SYSTEM
Lung (10) (10) (10) (10) (10) (10)
Infiltration Cellular, Histiocyte 1 (10%)
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SPECIAL SENSES SYSTEM
None
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URINARY SYSTEM
None
a Number of animals examined microscopically at site and number of animals with lesion
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