TDMS Study 96020-01 Pathology Tables
NTP Experiment-Test: 96020-01 INCIDENCE RATES OF NONNEOPLASTIC LESIONS BY ANATOMIC SITE (a) Report: PEIRPT03
Study Type: CHRONIC TEF EVALUATION (BINARY MIXTURE; PCB 126/PCB 153) Date: 03/03/04
Route: GAVAGE Time: 13:18:26
31 WEEK SSAC FINAL #1
Facility: Battelle Columbus Laboratory
Chemical CAS #: TEFBINARYMIX
Lock Date: 03/27/02
Cage Range: All
Reasons For Removal: 25017 Scheduled Sacrifice
Removal Date Range: 04/14/99 - 04/15/99
Treatment Groups: Include 001 0 NG / 0 UG
Include 002 10 NG / 10 UG
Include 003 100 NG /100 UG
Include 005 300 NG /300 UG
Include 007 1000 NG/1000 UG
a Number of animals examined microscopically at site and number of animals with lesion
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NTP Experiment-Test: 96020-01 INCIDENCE RATES OF NONNEOPLASTIC LESIONS BY ANATOMIC SITE (a) Report: PEIRPT03
Study Type: CHRONIC TEF EVALUATION (BINARY MIXTURE; PCB 126/PCB 153) Date: 03/03/04
Route: GAVAGE Time: 13:18:26
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SPRAGUE-DAWLEY RATS FEMALE 0 NG / 10 NG / 100 NG / 300 NG / 1000 NG/
0 UG 10 UG 100 UG 300 UG 1000 UG
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DISPOSITION SUMMARY
Animals Initially In Study 98 86 98 98 98
Scheduled Sacrifice 16 10 16 16 16
Early Deaths
Survivors
Animals Examined Microscopically 10 10 10 10 10
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ALIMENTARY SYSTEM
Liver (10) (10) (10) (10) (10)
Clear Cell Focus 1 (10%)
Fatty Change, Diffuse 1 (10%) 10 (100%)
Inflammation 10 (100%) 10 (100%) 10 (100%) 10 (100%) 10 (100%)
Mixed Cell Focus 1 (10%) 2 (20%) 3 (30%) 2 (20%)
Mixed Cell Focus, Multiple 1 (10%) 1 (10%) 1 (10%) 3 (30%) 3 (30%)
Pigmentation 3 (30%) 10 (100%) 10 (100%)
Toxic Hepatopathy 5 (50%)
Bile Duct, Hyperplasia 1 (10%) 2 (20%)
Bile Duct, Inflammation, Chronic Active,
Focal 1 (10%)
Hepatocyte, Hypertrophy 3 (30%) 5 (50%) 10 (100%) 10 (100%)
Hepatocyte, Multinucleated 9 (90%)
Pancreas (10) (10) (10) (10) (10)
Basophilic Focus 1 (10%)
Inflammation, Chronic Active 1 (10%) 1 (10%) 1 (10%)
Acinus, Atrophy 1 (10%) 1 (10%) 1 (10%)
Acinus, Vacuolization Cytoplasmic 3 (30%)
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CARDIOVASCULAR SYSTEM
None
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ENDOCRINE SYSTEM
Adrenal Cortex (10) (10) (10) (10) (10)
Degeneration, Cystic 1 (10%) 1 (10%)
Hyperplasia 1 (10%) 2 (20%)
Hypertrophy 3 (30%) 2 (20%) 2 (20%) 4 (40%) 1 (10%)
a Number of animals examined microscopically at site and number of animals with lesion
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NTP Experiment-Test: 96020-01 INCIDENCE RATES OF NONNEOPLASTIC LESIONS BY ANATOMIC SITE (a) Report: PEIRPT03
Study Type: CHRONIC TEF EVALUATION (BINARY MIXTURE; PCB 126/PCB 153) Date: 03/03/04
Route: GAVAGE Time: 13:18:26
____________________________________________________________________________________________________________________________________
SPRAGUE-DAWLEY RATS FEMALE 0 NG / 10 NG / 100 NG / 300 NG / 1000 NG/
0 UG 10 UG 100 UG 300 UG 1000 UG
____________________________________________________________________________________________________________________________________
ENDOCRINE SYSTEM - CONT
Vacuolization Cytoplasmic 1 (10%)
Thyroid Gland (10) (10) (10) (10) (10)
Follicular Cell, Hypertrophy 5 (50%) 5 (50%) 7 (70%) 8 (80%)
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GENERAL BODY SYSTEM
None
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GENITAL SYSTEM
Ovary (10) (10) (10) (10) (10)
Atrophy 6 (60%) 7 (70%) 9 (90%) 10 (100%) 6 (60%)
Uterus (10) (10) (10) (10) (10)
Inflammation, Suppurative 1 (10%) 1 (10%)
Metaplasia, Squamous 6 (60%) 7 (70%) 5 (50%) 9 (90%) 4 (40%)
Endometrium, Hyperplasia, Cystic 1 (10%) 1 (10%)
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HEMATOPOIETIC SYSTEM
Lymph Node (1)
Mediastinal, Inflammation, Granulomatous 1 (100%)
Spleen (10)
Pigmentation 10 (100%)
Thymus (10) (10) (10) (10) (10)
Atrophy 6 (60%) 5 (50%) 6 (60%) 7 (70%) 10 (100%)
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INTEGUMENTARY SYSTEM
None
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MUSCULOSKELETAL SYSTEM
None
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NERVOUS SYSTEM
None
a Number of animals examined microscopically at site and number of animals with lesion
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NTP Experiment-Test: 96020-01 INCIDENCE RATES OF NONNEOPLASTIC LESIONS BY ANATOMIC SITE (a) Report: PEIRPT03
Study Type: CHRONIC TEF EVALUATION (BINARY MIXTURE; PCB 126/PCB 153) Date: 03/03/04
Route: GAVAGE Time: 13:18:26
____________________________________________________________________________________________________________________________________
SPRAGUE-DAWLEY RATS FEMALE 0 NG / 10 NG / 100 NG / 300 NG / 1000 NG/
0 UG 10 UG 100 UG 300 UG 1000 UG
____________________________________________________________________________________________________________________________________
RESPIRATORY SYSTEM
Lung (10) (10) (10) (10) (10)
Hemorrhage 1 (10%)
Infiltration Cellular, Histiocyte 2 (20%) 1 (10%) 1 (10%) 4 (40%)
Inflammation 1 (10%)
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SPECIAL SENSES SYSTEM
None
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URINARY SYSTEM
None
a Number of animals examined microscopically at site and number of animals with lesion
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