TDMS Study 96020-01 Pathology Tables
NTP STATISTICAL ANALYSIS OF NON-NEOPLASTIC LESIONS REPORT: PEIRPT10
LAB: Battelle Columbus TEF EVALUATION (BINARY MIXTURE; PCB 126/PCB 153) DATE: 03/03/04
EXPERIMENT: 96020 TEST: 01 TIME: 10:01:10
TEST TYPE: CHRONIC CAGES FROM 0000 TO LAST CAGE PAGE: 1
CONT: NO1-ES-75411 ROUTE: GAVAGE NTP C#: C96020
PATHOLOGIST: SELLS, DONALD CAS: TEFBINARYMIX
------------------------------------------------------------------------------------------------------------------------------------
FINAL #1
REASONS FOR REMOVAL: 25018 Dosing Accident
25019 Moribund Sacrifice
25020 Natural Death
25021 Terminal Sacrifice
REMOVAL DATE RANGE: ALL
TREATMENT GROUPS: INCLUDE 001 0 NG / 0 UG
INCLUDE 002 10 NG / 10 UG
INCLUDE 003 100 NG /100 UG
INCLUDE 005 300 NG /300 UG
INCLUDE 007 1000 NG/1000 UG
NTP STATISTICAL ANALYSIS OF NON-NEOPLASTIC LESIONS REPORT: PEIRPT10
LAB: Battelle Columbus TEF EVALUATION (BINARY MIXTURE; PCB 126/PCB 153) DATE: 03/03/04
EXPERIMENT: 96020 TEST: 01 TIME: 10:01:10
TEST TYPE: CHRONIC CAGES FROM 0000 TO LAST CAGE
CONT: NO1-ES-75411 ROUTE: GAVAGE NTP C#: C96020
PATHOLOGIST: SELLS, DONALD CAS: TEFBINARYMIX
SUMMARY OF STATISTICALLY SIGNIFICANT (P<=.05) RESULTS
IN THE ANALYSIS OF TEF EVALUATION (BINARY MIXTURE; PCB 126
===============================================================
Female Rats
------------
Organ Morphology
----- ----------
Adrenal Cortex Angiectasis
Atrophy
Hyperplasia
Hypertrophy
Adrenal Medulla Hyperplasia
Bone Marrow Hyperplasia
Clitoral Gland Inflammation
Clitoral Gland: Duct Cyst
Esophagus Perforation
Eye: Anterior Chamber, Ciliary Body, Cornea
Inflammation
Heart: Coronary Artery Inflammation Chronic
Kidney Calculus Micro Observation Only
Nephropathy
Pigmentation
Kidney: Transitional Epithelium Hyperplasia
Liver Angiectasis
Basophilic Focus
Cholangiofibrosis
Clear Cell Focus
Eosinophilic Focus
Fatty Change Diffuse
Fatty Change Focal
Hematopoietic Cell Proliferation
Hyperplasia
Mixed Cell Focus
Necrosis
Pigmentation
Toxic Hepatopathy
Liver: Bile Duct Cyst
Hyperplasia
Liver: Hepatocyte Hypertrophy
Multinucleated
Liver: Oval Cell Hyperplasia
Liver: Portal Fibrosis
Lung Inflammation
Metaplasia
Lung: Alveolar Epithelium Hyperplasia
Metaplasia Bronchiolar
Lymph Node, Mandibular Ectasia
Hyperplasia Lymphoid
Lymph Node, Mesenteric Hyperplasia
Lymph Node: Lumbar Ectasia
Hyperplasia
Lymph Node: Mediastinal Ectasia
Hemorrhage
Hyperplasia
NTP STATISTICAL ANALYSIS OF NON-NEOPLASTIC LESIONS REPORT: PEIRPT10
LAB: Battelle Columbus TEF EVALUATION (BINARY MIXTURE; PCB 126/PCB 153) DATE: 03/03/04
EXPERIMENT: 96020 TEST: 01 TIME: 10:01:10
TEST TYPE: CHRONIC CAGES FROM 0000 TO LAST CAGE
CONT: NO1-ES-75411 ROUTE: GAVAGE NTP C#: C96020
PATHOLOGIST: SELLS, DONALD CAS: TEFBINARYMIX
Mammary Gland Hyperplasia
Inflammation Granulomatous
Mesentery: Artery Inflammation Chronic
Nose Inflammation
Nose: Glands Hyperplasia
Nose: Olfactory Epithelium Metaplasia
Nose: Respiratory Epithelium Hyperplasia
Ovary Atrophy
Oviduct Cyst
Inflammation Chronic
Pancreas Inflammation Chronic
Pancreas: Acinus Atrophy
Vacuolization Cytoplasmic
Pituitary Gland Angiectasis
Pituitary Gland: Pars Intermedia Hyperplasia
Spleen Hematopoietic Cell Proliferation
Spleen: Lymphoid Follicle Atrophy
Spleen: Red Pulp Atrophy
Stomach, Forestomach Hyperplasia
Stomach, Glandular Erosion
Mineralization
Thymus Atrophy
Hyperplasia Lymphoid
Thyroid Gland: Follicle Cyst
Thyroid Gland: Follicular Cell Hypertrophy
Urinary Bladder Inflammation
Uterus Inflammation
Metaplasia
Uterus: Endometrium Hyperplasia Cystic
===============================================================
Date: 03/03/04 EXPERIMENT: 96020 TEST: 01 Page 1
Statistical Analysis of Non-neoplastic Lesions in Rats(SPRAGUE-DAWLEY) - TEF EVALUATION (BINARY MIXTURE; PCB 126
Terminal Sacrifice at 105 weeks
|=================================================================================================================================|
| | |
| | Females |
|Dose | 0 NG / 10 NG / 100 NG / 300 NG / 1000 NG/ |
| | 0 UG 10 UG 100 UG 300 UG 1000 UG |
|=================================================================================================================================|
| |
|Adrenal Cortex |
| Angiectasis |
| |
| |
|---------------------------------------------------------------------------------------------------------------------------------|
|LESION RATES | |
|----------- | |
|OVERALL (a) | 17/53 (32%) 26/53 (49%) 33/52 (63%) 23/52 (44%) 5/51 (10%) |
|POLY-3 RATE (b) | 17/41.18 26/40.40 33/44.42 23/42.61 5/36.82 |
|POLY-3 PERCENT (g) | 41.3% 64.4% 74.3% 54.0% 13.6% |
|TERMINAL (d) | 11/22 (50%) 17/21 (81%) 19/22 (86%) 11/24 (46%) 4/24 (17%) |
|FIRST INCIDENCE | 418 469 254 499 558 |
|-------------------| |
|STATISTICAL TESTS | |
|-------------------| |
|LIFE TABLE | P<0.001N** P=0.041 * P=0.004 ** P=0.229 P=0.003N** |
|POLY 3 | P<0.001N** P=0.023 * P<0.001 ** P=0.164 P=0.005N** |
|POLY 1.5 | P<0.001N** P=0.028 * P<0.001 ** P=0.141 P=0.005N** |
|POLY 6 | P<0.001N** P=0.022 * P<0.001 ** P=0.220 P=0.004N** |
|LOGISTIC REGRESSION| P<0.001N** P=0.037 * P<0.001 ** P=0.132 P=0.006N** |
|COCH-ARM / FISHERS | P<0.001N** P=0.057 P<0.001 ** P=0.140 P=0.005N** |
|ORDER RESTRICTED | P<0.001N** (e) (e) (e) (e) |
|=================================================================================================================================|
| | |
| | Females |
|Dose | 0 NG / 10 NG / 100 NG / 300 NG / 1000 NG/ |
| | 0 UG 10 UG 100 UG 300 UG 1000 UG |
|=================================================================================================================================|
| |
|Adrenal Cortex |
| Atrophy |
| |
| |
|---------------------------------------------------------------------------------------------------------------------------------|
|LESION RATES | |
|----------- | |
|OVERALL (a) | 0/53 (0%) 0/53 (0%) 0/52 (0%) 3/52 (6%) 35/51 (69%) |
|POLY-3 RATE (b) | 0/38.18 0/37.40 0/38.82 3/37.99 35/41.50 |
|POLY-3 PERCENT (g) | 0.0% 0.0% 0.0% 7.9% 84.4% |
|TERMINAL (d) | 0/22 (0%) 0/21 (0%) 0/22 (0%) 2/24 (8%) 21/24 (88%) |
|FIRST INCIDENCE | --- --- --- 539 485 |
|-------------------| |
|STATISTICAL TESTS | |
|-------------------| |
|LIFE TABLE | P<0.001 ** (e) (e) P=0.133 P<0.001 ** |
|POLY 3 | P<0.001 ** (e) (e) P=0.117 P<0.001 ** |
|POLY 1.5 | P<0.001 ** (e) (e) P=0.115 P<0.001 ** |
|POLY 6 | P<0.001 ** (e) (e) P=0.119 P<0.001 ** |
|LOGISTIC REGRESSION| P<0.001 ** (e) (e) P=0.117 P<0.001 ** |
|COCH-ARM / FISHERS | P<0.001 ** (e) (e) P=0.118 P<0.001 ** |
|ORDER RESTRICTED | P<0.001 ** (e) (e) (e) (e) |
|=================================================================================================================================|
Date: 03/03/04 EXPERIMENT: 96020 TEST: 01 Page 2
Statistical Analysis of Non-neoplastic Lesions in Rats(SPRAGUE-DAWLEY) - TEF EVALUATION (BINARY MIXTURE; PCB 126
Terminal Sacrifice at 105 weeks
|=================================================================================================================================|
| | |
| | Females |
|Dose | 0 NG / 10 NG / 100 NG / 300 NG / 1000 NG/ |
| | 0 UG 10 UG 100 UG 300 UG 1000 UG |
|=================================================================================================================================|
| |
|Adrenal Cortex |
| Degeneration Cystic |
| |
| |
|---------------------------------------------------------------------------------------------------------------------------------|
|LESION RATES | |
|----------- | |
|OVERALL (a) | 13/53 (25%) 12/53 (23%) 13/52 (25%) 14/52 (27%) 16/51 (31%) |
|POLY-3 RATE (b) | 13/40.95 12/37.55 13/40.77 14/39.87 16/39.37 |
|POLY-3 PERCENT (g) | 31.7% 32.0% 31.9% 35.1% 40.6% |
|TERMINAL (d) | 6/22 (27%) 11/21 (52%) 6/22 (27%) 7/24 (29%) 10/24 (42%) |
|FIRST INCIDENCE | 556 689 581 505 477 |
|-------------------| |
|STATISTICAL TESTS | |
|-------------------| |
|LIFE TABLE | P=0.261 P=0.548N P=0.580N P=0.521 P=0.354 |
|POLY 3 | P=0.188 P=0.589 P=0.590 P=0.465 P=0.271 |
|POLY 1.5 | P=0.173 P=0.566N P=0.583 P=0.466 P=0.264 |
|POLY 6 | P=0.207 P=0.541 P=0.593 P=0.469 P=0.277 |
|LOGISTIC REGRESSION| P=0.157 P=0.520N P=0.581N P=0.473 P=0.267 |
|COCH-ARM / FISHERS | P=0.179 P=0.500N P=0.567 P=0.477 P=0.288 |
|ORDER RESTRICTED | P=0.338 (e) (e) (e) (e) |
|=================================================================================================================================|
| | |
| | Females |
|Dose | 0 NG / 10 NG / 100 NG / 300 NG / 1000 NG/ |
| | 0 UG 10 UG 100 UG 300 UG 1000 UG |
|=================================================================================================================================|
| |
|Adrenal Cortex |
| Hyperplasia |
| |
| |
|---------------------------------------------------------------------------------------------------------------------------------|
|LESION RATES | |
|----------- | |
|OVERALL (a) | 11/53 (21%) 18/53 (34%) 23/52 (44%) 25/52 (48%) 18/51 (35%) |
|POLY-3 RATE (b) | 11/39.56 18/39.96 23/43.38 25/42.59 18/39.46 |
|POLY-3 PERCENT (g) | 27.8% 45.1% 53.0% 58.7% 45.6% |
|TERMINAL (d) | 7/22 (32%) 10/21 (48%) 10/22 (46%) 14/24 (58%) 11/24 (46%) |
|FIRST INCIDENCE | 499 469 458 254 477 |
|-------------------| |
|STATISTICAL TESTS | |
|-------------------| |
|LIFE TABLE | P=0.470 P=0.089 P=0.023 * P=0.010 * P=0.129 |
|POLY 3 | P=0.330 P=0.079 P=0.013 * P=0.003 ** P=0.072 |
|POLY 1.5 | P=0.304 P=0.078 P=0.010 * P=0.002 ** P=0.065 |
|POLY 6 | P=0.367 P=0.086 P=0.021 * P=0.004 ** P=0.088 |
|LOGISTIC REGRESSION| P=0.294 P=0.077 P=0.010 * P=0.002 ** P=0.063 |
|COCH-ARM / FISHERS | P=0.326 P=0.095 P=0.009 ** P=0.003 ** P=0.076 |
|ORDER RESTRICTED | P=0.015 * (e) (e) (e) (e) |
|=================================================================================================================================|
Date: 03/03/04 EXPERIMENT: 96020 TEST: 01 Page 3
Statistical Analysis of Non-neoplastic Lesions in Rats(SPRAGUE-DAWLEY) - TEF EVALUATION (BINARY MIXTURE; PCB 126
Terminal Sacrifice at 105 weeks
|=================================================================================================================================|
| | |
| | Females |
|Dose | 0 NG / 10 NG / 100 NG / 300 NG / 1000 NG/ |
| | 0 UG 10 UG 100 UG 300 UG 1000 UG |
|=================================================================================================================================|
| |
|Adrenal Cortex |
| Hypertrophy |
| |
| |
|---------------------------------------------------------------------------------------------------------------------------------|
|LESION RATES | |
|----------- | |
|OVERALL (a) | 47/53 (89%) 38/53 (72%) 44/52 (85%) 41/52 (79%) 32/51 (63%) |
|POLY-3 RATE (b) | 47/49.32 38/45.04 44/47.46 41/44.30 32/42.27 |
|POLY-3 PERCENT (g) | 95.3% 84.4% 92.7% 92.6% 75.7% |
|TERMINAL (d) | 21/22 (96%) 19/21 (91%) 20/22 (91%) 24/24 (100%) 17/24 (71%) |
|FIRST INCIDENCE | 418 296 461 479 485 |
|-------------------| |
|STATISTICAL TESTS | |
|-------------------| |
|LIFE TABLE | P=0.016N* P=0.165N P=0.358N P=0.163N P=0.016N* |
|POLY 3 | P=0.003N** P=0.055N P=0.453N P=0.441N P=0.003N** |
|POLY 1.5 | P=0.003N** P=0.033N* P=0.409N P=0.258N P=0.002N** |
|POLY 6 | P=0.005N** P=0.087N P=0.502N P=0.667N P=0.008N** |
|LOGISTIC REGRESSION| P=0.002N** P=0.027N* P=0.270N P=0.103N P<0.001N** |
|COCH-ARM / FISHERS | P=0.005N** P=0.025N* P=0.373N P=0.135N P=0.002N** |
|ORDER RESTRICTED | P<0.001N** (e) (e) (e) (e) |
|=================================================================================================================================|
| | |
| | Females |
|Dose | 0 NG / 10 NG / 100 NG / 300 NG / 1000 NG/ |
| | 0 UG 10 UG 100 UG 300 UG 1000 UG |
|=================================================================================================================================|
| |
|Adrenal Cortex |
| Vacuolization Cytoplasmic |
| |
| |
|---------------------------------------------------------------------------------------------------------------------------------|
|LESION RATES | |
|----------- | |
|OVERALL (a) | 11/53 (21%) 12/53 (23%) 14/52 (27%) 10/52 (19%) 13/51 (25%) |
|POLY-3 RATE (b) | 11/40.49 12/41.50 14/41.16 10/40.66 13/37.17 |
|POLY-3 PERCENT (g) | 27.2% 28.9% 34.0% 24.6% 35.0% |
|TERMINAL (d) | 6/22 (27%) 4/21 (19%) 6/22 (27%) 3/24 (13%) 9/24 (38%) |
|FIRST INCIDENCE | 451 367 458 330 606 |
|-------------------| |
|STATISTICAL TESTS | |
|-------------------| |
|LIFE TABLE | P=0.500 P=0.472 P=0.359 P=0.469N P=0.458 |
|POLY 3 | P=0.329 P=0.528 P=0.331 P=0.495N P=0.306 |
|POLY 1.5 | P=0.350 P=0.508 P=0.320 P=0.509N P=0.316 |
|POLY 6 | P=0.310 P=0.559 P=0.346 P=0.472N P=0.302 |
|LOGISTIC REGRESSION| P=0.397 P=0.494 P=0.325 P=0.521N P=0.350 |
|COCH-ARM / FISHERS | P=0.415 P=0.500 P=0.304 P=0.520N P=0.367 |
|ORDER RESTRICTED | P=0.396 (e) (e) (e) (e) |
|=================================================================================================================================|
Date: 03/03/04 EXPERIMENT: 96020 TEST: 01 Page 4
Statistical Analysis of Non-neoplastic Lesions in Rats(SPRAGUE-DAWLEY) - TEF EVALUATION (BINARY MIXTURE; PCB 126
Terminal Sacrifice at 105 weeks
|=================================================================================================================================|
| | |
| | Females |
|Dose | 0 NG / 10 NG / 100 NG / 300 NG / 1000 NG/ |
| | 0 UG 10 UG 100 UG 300 UG 1000 UG |
|=================================================================================================================================|
| |
|Adrenal Medulla |
| Hyperplasia |
| |
| |
|---------------------------------------------------------------------------------------------------------------------------------|
|LESION RATES | |
|----------- | |
|OVERALL (a) | 15/52 (29%) 13/53 (25%) 14/52 (27%) 13/52 (25%) 3/51 (6%) |
|POLY-3 RATE (b) | 15/38.71 13/39.25 14/41.19 13/39.45 3/37.96 |
|POLY-3 PERCENT (g) | 38.8% 33.1% 34.0% 33.0% 7.9% |
|TERMINAL (d) | 9/21 (43%) 8/21 (38%) 8/22 (36%) 9/24 (38%) 0/24 (0%) |
|FIRST INCIDENCE | 556 534 458 479 314 |
|-------------------| |
|STATISTICAL TESTS | |
|-------------------| |
|LIFE TABLE | P<0.001N** P=0.428N P=0.456N P=0.321N P=0.002N** |
|POLY 3 | P<0.001N** P=0.386N P=0.415N P=0.380N P<0.001N** |
|POLY 1.5 | P<0.001N** P=0.399N P=0.448N P=0.397N P<0.001N** |
|POLY 6 | P<0.001N** P=0.363N P=0.387N P=0.360N P<0.001N** |
|LOGISTIC REGRESSION| P<0.001N** P=0.393N P=0.443N P=0.399N P=0.002N** |
|COCH-ARM / FISHERS | P=0.002N** P=0.390N P=0.500N P=0.413N P=0.002N** |
|ORDER RESTRICTED | P=0.002N** (e) (e) (e) (e) |
|=================================================================================================================================|
| | |
| | Females |
|Dose | 0 NG / 10 NG / 100 NG / 300 NG / 1000 NG/ |
| | 0 UG 10 UG 100 UG 300 UG 1000 UG |
|=================================================================================================================================|
| |
|Bone Marrow |
| Hyperplasia |
| |
| |
|---------------------------------------------------------------------------------------------------------------------------------|
|LESION RATES | |
|----------- | |
|OVERALL (a) | 39/53 (74%) 38/53 (72%) 42/53 (79%) 48/53 (91%) 49/53 (92%) |
|POLY-3 RATE (b) | 39/51.35 38/51.35 42/53.00 48/53.00 49/50.85 |
|POLY-3 PERCENT (g) | 76.0% 74.0% 79.3% 90.6% 96.4% |
|TERMINAL (d) | 12/22 (55%) 10/21 (48%) 11/22 (50%) 19/24 (79%) 23/24 (96%) |
|FIRST INCIDENCE | 85 167 125 96 71 |
|-------------------| |
|STATISTICAL TESTS | |
|-------------------| |
|LIFE TABLE | P=0.087 P=0.548 P=0.439 P=0.186 P=0.131 |
|POLY 3 | P<0.001 ** P=0.500N P=0.433 P=0.037 * P=0.002 ** |
|POLY 1.5 | P<0.001 ** P=0.502N P=0.391 P=0.029 * P=0.003 ** |
|POLY 6 | P<0.001 ** P=0.497N P=0.479 P=0.048 * P=0.002 ** |
|LOGISTIC REGRESSION| P=0.002 ** P=0.476N P=0.282 P=0.019 * P=0.012 * |
|COCH-ARM / FISHERS | P=0.002 ** P=0.500N P=0.324 P=0.020 * P=0.009 ** |
|ORDER RESTRICTED | P=0.003 ** (e) (e) (e) (e) |
|=================================================================================================================================|
Date: 03/03/04 EXPERIMENT: 96020 TEST: 01 Page 5
Statistical Analysis of Non-neoplastic Lesions in Rats(SPRAGUE-DAWLEY) - TEF EVALUATION (BINARY MIXTURE; PCB 126
Terminal Sacrifice at 105 weeks
|=================================================================================================================================|
| | |
| | Females |
|Dose | 0 NG / 10 NG / 100 NG / 300 NG / 1000 NG/ |
| | 0 UG 10 UG 100 UG 300 UG 1000 UG |
|=================================================================================================================================|
| |
|Clitoral Gland |
| Inflammation |
| |
| |
|---------------------------------------------------------------------------------------------------------------------------------|
|LESION RATES | |
|----------- | |
|OVERALL (a) | 45/53 (85%) 49/53 (92%) 46/53 (87%) 40/53 (75%) 23/50 (46%) |
|POLY-3 RATE (b) | 45/50.91 49/50.52 46/51.41 40/48.52 23/41.02 |
|POLY-3 PERCENT (g) | 88.4% 97.0% 89.5% 82.4% 56.1% |
|TERMINAL (d) | 18/22 (82%) 21/21 (100%) 20/22 (91%) 17/24 (71%) 12/24 (50%) |
|FIRST INCIDENCE | 345 178 125 254 479 |
|-------------------| |
|STATISTICAL TESTS | |
|-------------------| |
|LIFE TABLE | P<0.001N** P=0.282 P=0.534 P=0.253N P<0.001N** |
|POLY 3 | P<0.001N** P=0.085 P=0.558 P=0.282N P<0.001N** |
|POLY 1.5 | P<0.001N** P=0.110 P=0.575 P=0.244N P<0.001N** |
|POLY 6 | P<0.001N** P=0.065 P=0.526 P=0.313N P<0.001N** |
|LOGISTIC REGRESSION| P<0.001N** P=0.153 P=0.501 P=0.180N P<0.001N** |
|COCH-ARM / FISHERS | P<0.001N** P=0.179 P=0.500 P=0.165N P<0.001N** |
|ORDER RESTRICTED | P<0.001N** (e) (e) (e) (e) |
|=================================================================================================================================|
| | |
| | Females |
|Dose | 0 NG / 10 NG / 100 NG / 300 NG / 1000 NG/ |
| | 0 UG 10 UG 100 UG 300 UG 1000 UG |
|=================================================================================================================================|
| |
|Clitoral Gland: Duct |
| Cyst |
| |
| |
|---------------------------------------------------------------------------------------------------------------------------------|
|LESION RATES | |
|----------- | |
|OVERALL (a) | 38/53 (72%) 40/53 (75%) 48/53 (91%) 43/53 (81%) 43/50 (86%) |
|POLY-3 RATE (b) | 38/50.38 40/47.56 48/50.11 43/48.31 43/46.44 |
|POLY-3 PERCENT (g) | 75.4% 84.1% 95.8% 89.0% 92.6% |
|TERMINAL (d) | 13/22 (59%) 18/21 (86%) 21/22 (96%) 21/24 (88%) 21/24 (88%) |
|FIRST INCIDENCE | 345 178 254 254 206 |
|-------------------| |
|STATISTICAL TESTS | |
|-------------------| |
|LIFE TABLE | P=0.472 P=0.379 P=0.141 P=0.346 P=0.310 |
|POLY 3 | P=0.058 P=0.198 P=0.002 ** P=0.057 P=0.018 * |
|POLY 1.5 | P=0.052 P=0.267 P=0.004 ** P=0.084 P=0.019 * |
|POLY 6 | P=0.078 P=0.141 P=0.002 ** P=0.038 * P=0.020 * |
|LOGISTIC REGRESSION| P=0.095 P=0.403 P=0.013 * P=0.168 P=0.054 |
|COCH-ARM / FISHERS | P=0.124 P=0.413 P=0.012 * P=0.180 P=0.062 |
|ORDER RESTRICTED | P=0.005 ** (e) (e) (e) (e) |
|=================================================================================================================================|
Date: 03/03/04 EXPERIMENT: 96020 TEST: 01 Page 6
Statistical Analysis of Non-neoplastic Lesions in Rats(SPRAGUE-DAWLEY) - TEF EVALUATION (BINARY MIXTURE; PCB 126
Terminal Sacrifice at 105 weeks
|=================================================================================================================================|
| | |
| | Females |
|Dose | 0 NG / 10 NG / 100 NG / 300 NG / 1000 NG/ |
| | 0 UG 10 UG 100 UG 300 UG 1000 UG |
|=================================================================================================================================|
| |
|Esophagus |
| Perforation |
| |
| |
|---------------------------------------------------------------------------------------------------------------------------------|
|LESION RATES | |
|----------- | |
|OVERALL (a) | 0/53 (0%) 0/53 (0%) 1/52 (2%) 0/53 (0%) 2/52 (4%) |
|POLY-3 RATE (b) | 0/38.18 0/37.40 1/39.82 0/37.40 2/38.26 |
|POLY-3 PERCENT (g) | 0.0% 0.0% 2.5% 0.0% 5.2% |
|TERMINAL (d) | 0/22 (0%) 0/21 (0%) 0/22 (0%) 0/24 (0%) 0/24 (0%) |
|FIRST INCIDENCE | --- --- 125 --- 71 |
|-------------------| |
|STATISTICAL TESTS | |
|-------------------| |
|LIFE TABLE | P=0.079 (e) P=0.504 (e) P=0.238 |
|POLY 3 | P=0.081 (e) P=0.508 (e) P=0.237 |
|POLY 1.5 | P=0.080 (e) P=0.505 (e) P=0.234 |
|POLY 6 | P=0.083 (e) P=0.511 (e) P=0.241 |
|LOGISTIC REGRESSION| P=0.463 (e) P=0.425 (e) (e) |
|COCH-ARM / FISHERS | P=0.079 (e) P=0.495 (e) P=0.243 |
|ORDER RESTRICTED | P=0.047 * (e) (e) (e) (e) |
|=================================================================================================================================|
| | |
| | Females |
|Dose | 0 NG / 10 NG / 100 NG / 300 NG / 1000 NG/ |
| | 0 UG 10 UG 100 UG 300 UG 1000 UG |
|=================================================================================================================================|
| |
|Esophagus: Muscularis |
| Inflammation |
| |
| |
|---------------------------------------------------------------------------------------------------------------------------------|
|LESION RATES | |
|----------- | |
|OVERALL (a) | 3/53 (6%) 1/53 (2%) 1/52 (2%) 3/53 (6%) 3/52 (6%) |
|POLY-3 RATE (b) | 3/39.27 1/37.65 1/38.82 3/39.07 3/37.26 |
|POLY-3 PERCENT (g) | 7.6% 2.7% 2.6% 7.7% 8.1% |
|TERMINAL (d) | 1/22 (5%) 0/21 (0%) 1/22 (5%) 0/24 (0%) 2/24 (8%) |
|FIRST INCIDENCE | 85 661 729 (T) 499 76 |
|-------------------| |
|STATISTICAL TESTS | |
|-------------------| |
|LIFE TABLE | P=0.331 P=0.320N P=0.301N P=0.649N P=0.642N |
|POLY 3 | P=0.307 P=0.319N P=0.308N P=0.661 P=0.639 |
|POLY 1.5 | P=0.306 P=0.320N P=0.312N P=0.653 P=0.636 |
|POLY 6 | P=0.309 P=0.316N P=0.306N P=0.653N P=0.645 |
|LOGISTIC REGRESSION| P=0.358 P=0.286N P=0.324N P=0.630N P=0.608N |
|COCH-ARM / FISHERS | P=0.316 P=0.309N P=0.316N P=0.661N P=0.652 |
|ORDER RESTRICTED | P=0.422 (e) (e) (e) (e) |
|=================================================================================================================================|
Date: 03/03/04 EXPERIMENT: 96020 TEST: 01 Page 7
Statistical Analysis of Non-neoplastic Lesions in Rats(SPRAGUE-DAWLEY) - TEF EVALUATION (BINARY MIXTURE; PCB 126
Terminal Sacrifice at 105 weeks
|=================================================================================================================================|
| | |
| | Females |
|Dose | 0 NG / 10 NG / 100 NG / 300 NG / 1000 NG/ |
| | 0 UG 10 UG 100 UG 300 UG 1000 UG |
|=================================================================================================================================|
| |
|Eye: Anterior Chamber, Ciliary Body, Cornea |
| Inflammation |
| |
| |
|---------------------------------------------------------------------------------------------------------------------------------|
|LESION RATES | |
|----------- | |
|OVERALL (a) | 0/53 (0%) 0/53 (0%) 0/53 (0%) 1/52 (2%) 3/52 (6%) |
|POLY-3 RATE (b) | 0/38.18 0/37.40 0/39.03 1/37.28 3/37.17 |
|POLY-3 PERCENT (g) | 0.0% 0.0% 0.0% 2.7% 8.1% |
|TERMINAL (d) | 0/22 (0%) 0/21 (0%) 0/22 (0%) 0/24 (0%) 0/24 (0%) |
|FIRST INCIDENCE | --- --- --- 580 563 |
|-------------------| |
|STATISTICAL TESTS | |
|-------------------| |
|LIFE TABLE | P=0.006 ** (e) (e) P=0.500 P=0.121 |
|POLY 3 | P=0.006 ** (e) (e) P=0.495 P=0.113 |
|POLY 1.5 | P=0.006 ** (e) (e) P=0.493 P=0.110 |
|POLY 6 | P=0.006 ** (e) (e) P=0.500 P=0.118 |
|LOGISTIC REGRESSION| P=0.007 ** (e) (e) P=0.502 P=0.114 |
|COCH-ARM / FISHERS | P=0.007 ** (e) (e) P=0.495 P=0.118 |
|ORDER RESTRICTED | P=0.010 * (e) (e) (e) (e) |
|=================================================================================================================================|
| | |
| | Females |
|Dose | 0 NG / 10 NG / 100 NG / 300 NG / 1000 NG/ |
| | 0 UG 10 UG 100 UG 300 UG 1000 UG |
|=================================================================================================================================|
| |
|Eye: Retina |
| Atrophy |
| |
| |
|---------------------------------------------------------------------------------------------------------------------------------|
|LESION RATES | |
|----------- | |
|OVERALL (a) | 1/53 (2%) 3/53 (6%) 4/53 (8%) 2/52 (4%) 5/52 (10%) |
|POLY-3 RATE (b) | 1/38.18 3/37.65 4/39.09 2/36.79 5/36.27 |
|POLY-3 PERCENT (g) | 2.6% 8.0% 10.2% 5.4% 13.8% |
|TERMINAL (d) | 1/22 (5%) 2/21 (10%) 3/22 (14%) 2/24 (8%) 5/24 (21%) |
|FIRST INCIDENCE | 729 (T) 661 715 729 (T) 729 (T) |
|-------------------| |
|STATISTICAL TESTS | |
|-------------------| |
|LIFE TABLE | P=0.183 P=0.293 P=0.188 P=0.531 P=0.118 |
|POLY 3 | P=0.130 P=0.299 P=0.184 P=0.487 P=0.087 |
|POLY 1.5 | P=0.130 P=0.298 P=0.182 P=0.485 P=0.087 |
|POLY 6 | P=0.131 P=0.303 P=0.185 P=0.492 P=0.088 |
|LOGISTIC REGRESSION| P=0.147 P=0.299 P=0.191 P=0.531 P=0.118 |
|COCH-ARM / FISHERS | P=0.144 P=0.309 P=0.181 P=0.493 P=0.098 |
|ORDER RESTRICTED | P=0.056 (e) (e) (e) (e) |
|=================================================================================================================================|
Date: 03/03/04 EXPERIMENT: 96020 TEST: 01 Page 8
Statistical Analysis of Non-neoplastic Lesions in Rats(SPRAGUE-DAWLEY) - TEF EVALUATION (BINARY MIXTURE; PCB 126
Terminal Sacrifice at 105 weeks
|=================================================================================================================================|
| | |
| | Females |
|Dose | 0 NG / 10 NG / 100 NG / 300 NG / 1000 NG/ |
| | 0 UG 10 UG 100 UG 300 UG 1000 UG |
|=================================================================================================================================|
| |
|Harderian Gland |
| Inflammation |
| |
| |
|---------------------------------------------------------------------------------------------------------------------------------|
|LESION RATES | |
|----------- | |
|OVERALL (a) | 20/53 (38%) 14/53 (26%) 16/53 (30%) 14/52 (27%) 16/52 (31%) |
|POLY-3 RATE (b) | 20/41.85 14/39.14 16/42.74 14/39.15 16/39.43 |
|POLY-3 PERCENT (g) | 47.8% 35.8% 37.4% 35.8% 40.6% |
|TERMINAL (d) | 10/22 (46%) 7/21 (33%) 7/22 (32%) 10/24 (42%) 9/24 (38%) |
|FIRST INCIDENCE | 418 580 254 330 314 |
|-------------------| |
|STATISTICAL TESTS | |
|-------------------| |
|LIFE TABLE | P=0.414N P=0.200N P=0.275N P=0.131N P=0.265N |
|POLY 3 | P=0.527N P=0.185N P=0.223N P=0.185N P=0.329N |
|POLY 1.5 | P=0.535N P=0.175N P=0.235N P=0.181N P=0.335N |
|POLY 6 | P=0.524N P=0.190N P=0.214N P=0.194N P=0.327N |
|LOGISTIC REGRESSION| P=0.543N P=0.155N P=0.253N P=0.176N P=0.331N |
|COCH-ARM / FISHERS | P=0.493N P=0.149N P=0.269N P=0.165N P=0.293N |
|ORDER RESTRICTED | P=0.279N (e) (e) (e) (e) |
|=================================================================================================================================|
| | |
| | Females |
|Dose | 0 NG / 10 NG / 100 NG / 300 NG / 1000 NG/ |
| | 0 UG 10 UG 100 UG 300 UG 1000 UG |
|=================================================================================================================================|
| |
|Heart |
| Cardiomyopathy |
| |
| |
|---------------------------------------------------------------------------------------------------------------------------------|
|LESION RATES | |
|----------- | |
|OVERALL (a) | 22/53 (42%) 19/52 (37%) 22/52 (42%) 26/53 (49%) 15/52 (29%) |
|POLY-3 RATE (b) | 22/41.41 19/38.93 22/41.36 26/41.49 15/39.21 |
|POLY-3 PERCENT (g) | 53.1% 48.8% 53.2% 62.7% 38.3% |
|TERMINAL (d) | 14/22 (64%) 10/21 (48%) 13/22 (59%) 17/24 (71%) 8/24 (33%) |
|FIRST INCIDENCE | 449 589 458 96 314 |
|-------------------| |
|STATISTICAL TESTS | |
|-------------------| |
|LIFE TABLE | P=0.074N P=0.391N P=0.551N P=0.374 P=0.096N |
|POLY 3 | P=0.094N P=0.433N P=0.589 P=0.243 P=0.123N |
|POLY 1.5 | P=0.110N P=0.427N P=0.574 P=0.249 P=0.135N |
|POLY 6 | P=0.085N P=0.408N P=0.596N P=0.248 P=0.110N |
|LOGISTIC REGRESSION| P=0.127N P=0.394N P=0.554N P=0.233 P=0.143N |
|COCH-ARM / FISHERS | P=0.107N P=0.374N P=0.546 P=0.279 P=0.124N |
|ORDER RESTRICTED | P=0.097N (e) (e) (e) (e) |
|=================================================================================================================================|
Date: 03/03/04 EXPERIMENT: 96020 TEST: 01 Page 9
Statistical Analysis of Non-neoplastic Lesions in Rats(SPRAGUE-DAWLEY) - TEF EVALUATION (BINARY MIXTURE; PCB 126
Terminal Sacrifice at 105 weeks
|=================================================================================================================================|
| | |
| | Females |
|Dose | 0 NG / 10 NG / 100 NG / 300 NG / 1000 NG/ |
| | 0 UG 10 UG 100 UG 300 UG 1000 UG |
|=================================================================================================================================|
| |
|Heart: Coronary Artery |
| Inflammation Chronic |
| |
| |
|---------------------------------------------------------------------------------------------------------------------------------|
|LESION RATES | |
|----------- | |
|OVERALL (a) | 0/53 (0%) 0/52 (0%) 1/52 (2%) 0/53 (0%) 6/52 (12%) |
|POLY-3 RATE (b) | 0/38.18 0/36.71 1/38.82 0/37.40 6/36.27 |
|POLY-3 PERCENT (g) | 0.0% 0.0% 2.6% 0.0% 16.5% |
|TERMINAL (d) | 0/22 (0%) 0/21 (0%) 1/22 (5%) 0/24 (0%) 6/24 (25%) |
|FIRST INCIDENCE | --- --- 729 (T) --- 729 (T) |
|-------------------| |
|STATISTICAL TESTS | |
|-------------------| |
|LIFE TABLE | P<0.001 ** (e) P=0.500 (e) P=0.020 * |
|POLY 3 | P<0.001 ** (e) P=0.503 (e) P=0.012 * |
|POLY 1.5 | P<0.001 ** (e) P=0.501 (e) P=0.012 * |
|POLY 6 | P<0.001 ** (e) P=0.506 (e) P=0.012 * |
|LOGISTIC REGRESSION| (e) (e) P=0.500 (e) P=0.020 * |
|COCH-ARM / FISHERS | P<0.001 ** (e) P=0.495 (e) P=0.013 * |
|ORDER RESTRICTED | P<0.001 ** (e) (e) (e) (e) |
|=================================================================================================================================|
| | |
| | Females |
|Dose | 0 NG / 10 NG / 100 NG / 300 NG / 1000 NG/ |
| | 0 UG 10 UG 100 UG 300 UG 1000 UG |
|=================================================================================================================================|
| |
|Intestine Large, Colon |
| Parasite Metazoan |
| |
| |
|---------------------------------------------------------------------------------------------------------------------------------|
|LESION RATES | |
|----------- | |
|OVERALL (a) | 0/53 (0%) 2/53 (4%) 0/53 (0%) 0/52 (0%) 0/49 (0%) |
|POLY-3 RATE (b) | 0/38.18 2/38.33 0/39.03 0/37.39 0/35.41 |
|POLY-3 PERCENT (g) | 0.0% 5.2% 0.0% 0.0% 0.0% |
|TERMINAL (d) | 0/22 (0%) 0/21 (0%) 0/22 (0%) 0/24 (0%) 0/24 (0%) |
|FIRST INCIDENCE | --- 499 --- --- --- |
|-------------------| |
|STATISTICAL TESTS | |
|-------------------| |
|LIFE TABLE | P=0.370N P=0.240 (e) (e) (e) |
|POLY 3 | P=0.371N P=0.237 (e) (e) (e) |
|POLY 1.5 | P=0.373N P=0.235 (e) (e) (e) |
|POLY 6 | P=0.365N P=0.242 (e) (e) (e) |
|LOGISTIC REGRESSION| P=0.365N P=0.243 (e) (e) (e) |
|COCH-ARM / FISHERS | P=0.370N P=0.248 (e) (e) (e) |
|ORDER RESTRICTED | P=0.234N (e) (e) (e) (e) |
|=================================================================================================================================|
Date: 03/03/04 EXPERIMENT: 96020 TEST: 01 Page 10
Statistical Analysis of Non-neoplastic Lesions in Rats(SPRAGUE-DAWLEY) - TEF EVALUATION (BINARY MIXTURE; PCB 126
Terminal Sacrifice at 105 weeks
|=================================================================================================================================|
| | |
| | Females |
|Dose | 0 NG / 10 NG / 100 NG / 300 NG / 1000 NG/ |
| | 0 UG 10 UG 100 UG 300 UG 1000 UG |
|=================================================================================================================================|
| |
|Intestine Large, Rectum |
| Parasite Metazoan |
| |
| |
|---------------------------------------------------------------------------------------------------------------------------------|
|LESION RATES | |
|----------- | |
|OVERALL (a) | 2/53 (4%) 0/53 (0%) 0/53 (0%) 1/53 (2%) 3/50 (6%) |
|POLY-3 RATE (b) | 2/38.76 0/37.40 0/39.03 1/37.45 3/35.82 |
|POLY-3 PERCENT (g) | 5.2% 0.0% 0.0% 2.7% 8.4% |
|TERMINAL (d) | 0/22 (0%) 0/21 (0%) 0/22 (0%) 0/24 (0%) 3/24 (13%) |
|FIRST INCIDENCE | 636 --- --- 715 729 (T) |
|-------------------| |
|STATISTICAL TESTS | |
|-------------------| |
|LIFE TABLE | P=0.086 P=0.250N P=0.250N P=0.514N P=0.496 |
|POLY 3 | P=0.069 P=0.244N P=0.235N P=0.512N P=0.464 |
|POLY 1.5 | P=0.069 P=0.243N P=0.235N P=0.510N P=0.462 |
|POLY 6 | P=0.070 P=0.246N P=0.236N P=0.513N P=0.466 |
|LOGISTIC REGRESSION| P=0.072 P=0.240N P=0.236N P=0.506N P=0.476 |
|COCH-ARM / FISHERS | P=0.072 P=0.248N P=0.248N P=0.500N P=0.472 |
|ORDER RESTRICTED | P=0.079 (e) (e) (e) (e) |
|=================================================================================================================================|
| | |
| | Females |
|Dose | 0 NG / 10 NG / 100 NG / 300 NG / 1000 NG/ |
| | 0 UG 10 UG 100 UG 300 UG 1000 UG |
|=================================================================================================================================|
| |
|Intestine Small, Jejunum |
| Hyperplasia Lymphoid |
| |
| |
|---------------------------------------------------------------------------------------------------------------------------------|
|LESION RATES | |
|----------- | |
|OVERALL (a) | 0/53 (0%) 0/53 (0%) 1/52 (2%) 2/52 (4%) 1/49 (2%) |
|POLY-3 RATE (b) | 0/38.18 0/37.40 1/39.07 2/38.30 1/35.41 |
|POLY-3 PERCENT (g) | 0.0% 0.0% 2.6% 5.2% 2.8% |
|TERMINAL (d) | 0/22 (0%) 0/21 (0%) 0/22 (0%) 1/24 (4%) 1/24 (4%) |
|FIRST INCIDENCE | --- --- 664 330 729 (T) |
|-------------------| |
|STATISTICAL TESTS | |
|-------------------| |
|LIFE TABLE | P=0.386 (e) P=0.487 P=0.243 P=0.517 |
|POLY 3 | P=0.362 (e) P=0.505 P=0.237 P=0.485 |
|POLY 1.5 | P=0.355 (e) P=0.501 P=0.235 P=0.482 |
|POLY 6 | P=0.371 (e) P=0.508 P=0.240 P=0.490 |
|LOGISTIC REGRESSION| P=0.361 (e) P=0.500 P=0.237 P=0.517 |
|COCH-ARM / FISHERS | P=0.359 (e) P=0.495 P=0.243 P=0.480 |
|ORDER RESTRICTED | P=0.194 (e) (e) (e) (e) |
|=================================================================================================================================|
Date: 03/03/04 EXPERIMENT: 96020 TEST: 01 Page 11
Statistical Analysis of Non-neoplastic Lesions in Rats(SPRAGUE-DAWLEY) - TEF EVALUATION (BINARY MIXTURE; PCB 126
Terminal Sacrifice at 105 weeks
|=================================================================================================================================|
| | |
| | Females |
|Dose | 0 NG / 10 NG / 100 NG / 300 NG / 1000 NG/ |
| | 0 UG 10 UG 100 UG 300 UG 1000 UG |
|=================================================================================================================================|
| |
|Kidney |
| Accumulation, Hyaline Droplet |
| |
| |
|---------------------------------------------------------------------------------------------------------------------------------|
|LESION RATES | |
|----------- | |
|OVERALL (a) | 2/53 (4%) 0/53 (0%) 1/52 (2%) 1/52 (2%) 1/51 (2%) |
|POLY-3 RATE (b) | 2/39.63 0/37.40 1/39.26 1/38.39 1/37.24 |
|POLY-3 PERCENT (g) | 5.1% 0.0% 2.6% 2.6% 2.7% |
|TERMINAL (d) | 0/22 (0%) 0/21 (0%) 0/22 (0%) 0/24 (0%) 0/24 (0%) |
|FIRST INCIDENCE | 449 --- 603 142 206 |
|-------------------| |
|STATISTICAL TESTS | |
|-------------------| |
|LIFE TABLE | P=0.653 P=0.247N P=0.492N P=0.497N P=0.514N |
|POLY 3 | P=0.663 P=0.250N P=0.503N P=0.511N P=0.522N |
|POLY 1.5 | P=0.660 P=0.247N P=0.504N P=0.509N P=0.521N |
|POLY 6 | P=0.664N P=0.252N P=0.502N P=0.512N P=0.522N |
|LOGISTIC REGRESSION| P=0.557N P=0.212N P=0.526N P=0.480N P=0.406N |
|COCH-ARM / FISHERS | P=0.658 P=0.248N P=0.507N P=0.507N P=0.515N |
|ORDER RESTRICTED | P=0.346N (e) (e) (e) (e) |
|=================================================================================================================================|
| | |
| | Females |
|Dose | 0 NG / 10 NG / 100 NG / 300 NG / 1000 NG/ |
| | 0 UG 10 UG 100 UG 300 UG 1000 UG |
|=================================================================================================================================|
| |
|Kidney |
| Calculus Micro Observation Only |
| |
| |
|---------------------------------------------------------------------------------------------------------------------------------|
|LESION RATES | |
|----------- | |
|OVERALL (a) | 7/53 (13%) 4/53 (8%) 1/52 (2%) 4/52 (8%) 1/51 (2%) |
|POLY-3 RATE (b) | 7/38.73 4/37.96 1/39.26 4/39.34 1/36.26 |
|POLY-3 PERCENT (g) | 18.1% 10.5% 2.6% 10.2% 2.8% |
|TERMINAL (d) | 5/22 (23%) 1/21 (5%) 0/22 (0%) 0/24 (0%) 1/24 (4%) |
|FIRST INCIDENCE | 647 603 603 499 729 (T) |
|-------------------| |
|STATISTICAL TESTS | |
|-------------------| |
|LIFE TABLE | P=0.079N P=0.291N P=0.035N* P=0.253N P=0.029N* |
|POLY 3 | P=0.089N P=0.268N P=0.027N* P=0.248N P=0.035N* |
|POLY 1.5 | P=0.090N P=0.271N P=0.029N* P=0.261N P=0.037N* |
|POLY 6 | P=0.089N P=0.261N P=0.025N* P=0.229N P=0.034N* |
|LOGISTIC REGRESSION| P=0.089N P=0.266N P=0.029N* P=0.274N P=0.033N* |
|COCH-ARM / FISHERS | P=0.087N P=0.263N P=0.032N* P=0.274N P=0.034N* |
|ORDER RESTRICTED | P=0.014N* (e) (e) (e) (e) |
|=================================================================================================================================|
Date: 03/03/04 EXPERIMENT: 96020 TEST: 01 Page 12
Statistical Analysis of Non-neoplastic Lesions in Rats(SPRAGUE-DAWLEY) - TEF EVALUATION (BINARY MIXTURE; PCB 126
Terminal Sacrifice at 105 weeks
|=================================================================================================================================|
| | |
| | Females |
|Dose | 0 NG / 10 NG / 100 NG / 300 NG / 1000 NG/ |
| | 0 UG 10 UG 100 UG 300 UG 1000 UG |
|=================================================================================================================================|
| |
|Kidney |
| Casts Protein |
| |
| |
|---------------------------------------------------------------------------------------------------------------------------------|
|LESION RATES | |
|----------- | |
|OVERALL (a) | 2/53 (4%) 1/53 (2%) 0/52 (0%) 0/52 (0%) 0/51 (0%) |
|POLY-3 RATE (b) | 2/39.30 1/37.40 0/38.82 0/37.39 0/36.26 |
|POLY-3 PERCENT (g) | 5.1% 2.7% 0.0% 0.0% 0.0% |
|TERMINAL (d) | 0/22 (0%) 1/21 (5%) 0/22 (0%) 0/24 (0%) 0/24 (0%) |
|FIRST INCIDENCE | 345 729 (T) --- --- --- |
|-------------------| |
|STATISTICAL TESTS | |
|-------------------| |
|LIFE TABLE | P=0.227N P=0.511N P=0.242N P=0.249N P=0.255N |
|POLY 3 | P=0.232N P=0.517N P=0.239N P=0.248N P=0.255N |
|POLY 1.5 | P=0.232N P=0.514N P=0.240N P=0.246N P=0.255N |
|POLY 6 | P=0.231N P=0.519N P=0.239N P=0.248N P=0.254N |
|LOGISTIC REGRESSION| P=0.226N P=0.491N P=0.252N P=0.234N P=0.218N |
|COCH-ARM / FISHERS | P=0.231N P=0.500N P=0.252N P=0.252N P=0.257N |
|ORDER RESTRICTED | P=0.057N (e) (e) (e) (e) |
|=================================================================================================================================|
| | |
| | Females |
|Dose | 0 NG / 10 NG / 100 NG / 300 NG / 1000 NG/ |
| | 0 UG 10 UG 100 UG 300 UG 1000 UG |
|=================================================================================================================================|
| |
|Kidney |
| Inflammation |
| |
| |
|---------------------------------------------------------------------------------------------------------------------------------|
|LESION RATES | |
|----------- | |
|OVERALL (a) | 5/53 (9%) 3/53 (6%) 1/52 (2%) 5/52 (10%) 1/51 (2%) |
|POLY-3 RATE (b) | 5/38.24 3/37.40 1/39.26 5/37.96 1/36.26 |
|POLY-3 PERCENT (g) | 13.1% 8.0% 2.6% 13.2% 2.8% |
|TERMINAL (d) | 4/22 (18%) 3/21 (14%) 0/22 (0%) 4/24 (17%) 1/24 (4%) |
|FIRST INCIDENCE | 714 729 (T) 603 552 729 (T) |
|-------------------| |
|STATISTICAL TESTS | |
|-------------------| |
|LIFE TABLE | P=0.156N P=0.379N P=0.099N P=0.584N P=0.083N |
|POLY 3 | P=0.207N P=0.367N P=0.093N P=0.628 P=0.111N |
|POLY 1.5 | P=0.209N P=0.368N P=0.098N P=0.621 P=0.114N |
|POLY 6 | P=0.205N P=0.362N P=0.088N P=0.628N P=0.107N |
|LOGISTIC REGRESSION| P=0.197N P=0.359N P=0.095N P=0.630 P=0.087N |
|COCH-ARM / FISHERS | P=0.200N P=0.358N P=0.107N P=0.617 P=0.112N |
|ORDER RESTRICTED | P=0.075N (e) (e) (e) (e) |
|=================================================================================================================================|
Date: 03/03/04 EXPERIMENT: 96020 TEST: 01 Page 13
Statistical Analysis of Non-neoplastic Lesions in Rats(SPRAGUE-DAWLEY) - TEF EVALUATION (BINARY MIXTURE; PCB 126
Terminal Sacrifice at 105 weeks
|=================================================================================================================================|
| | |
| | Females |
|Dose | 0 NG / 10 NG / 100 NG / 300 NG / 1000 NG/ |
| | 0 UG 10 UG 100 UG 300 UG 1000 UG |
|=================================================================================================================================|
| |
|Kidney |
| Mineralization |
| |
| |
|---------------------------------------------------------------------------------------------------------------------------------|
|LESION RATES | |
|----------- | |
|OVERALL (a) | 42/53 (79%) 38/53 (72%) 39/52 (75%) 42/52 (81%) 35/51 (69%) |
|POLY-3 RATE (b) | 42/50.36 38/47.49 39/49.00 42/48.93 35/45.19 |
|POLY-3 PERCENT (g) | 83.4% 80.0% 79.6% 85.8% 77.5% |
|TERMINAL (d) | 15/22 (68%) 16/21 (76%) 19/22 (86%) 19/24 (79%) 17/24 (71%) |
|FIRST INCIDENCE | 85 178 125 254 71 |
|-------------------| |
|STATISTICAL TESTS | |
|-------------------| |
|LIFE TABLE | P=0.192N P=0.404N P=0.372N P=0.498N P=0.191N |
|POLY 3 | P=0.348N P=0.429N P=0.404N P=0.476 P=0.309N |
|POLY 1.5 | P=0.317N P=0.381N P=0.385N P=0.466 P=0.266N |
|POLY 6 | P=0.373N P=0.479N P=0.466N P=0.481 P=0.361N |
|LOGISTIC REGRESSION| P=0.222N P=0.257N P=0.400N P=0.519 P=0.163N |
|COCH-ARM / FISHERS | P=0.211N P=0.249N P=0.388N P=0.520 P=0.156N |
|ORDER RESTRICTED | P=0.379N (e) (e) (e) (e) |
|=================================================================================================================================|
| | |
| | Females |
|Dose | 0 NG / 10 NG / 100 NG / 300 NG / 1000 NG/ |
| | 0 UG 10 UG 100 UG 300 UG 1000 UG |
|=================================================================================================================================|
| |
|Kidney |
| Nephropathy |
| |
| |
|---------------------------------------------------------------------------------------------------------------------------------|
|LESION RATES | |
|----------- | |
|OVERALL (a) | 29/53 (55%) 22/53 (42%) 29/52 (56%) 34/52 (65%) 43/51 (84%) |
|POLY-3 RATE (b) | 29/44.67 22/40.11 29/41.95 34/43.59 43/44.94 |
|POLY-3 PERCENT (g) | 64.9% 54.9% 69.1% 78.0% 95.7% |
|TERMINAL (d) | 17/22 (77%) 14/21 (67%) 18/22 (82%) 23/24 (96%) 24/24 (100%) |
|FIRST INCIDENCE | 345 337 469 142 314 |
|-------------------| |
|STATISTICAL TESTS | |
|-------------------| |
|LIFE TABLE | P<0.001 ** P=0.175N P=0.539N P=0.320 P=0.023 * |
|POLY 3 | P<0.001 ** P=0.222N P=0.420 P=0.108 P<0.001 ** |
|POLY 1.5 | P<0.001 ** P=0.186N P=0.465 P=0.137 P<0.001 ** |
|POLY 6 | P<0.001 ** P=0.246N P=0.368 P=0.084 P<0.001 ** |
|LOGISTIC REGRESSION| P<0.001 ** P=0.132N P=0.567N P=0.165 P<0.001 ** |
|COCH-ARM / FISHERS | P<0.001 ** P=0.122N P=0.535 P=0.180 P<0.001 ** |
|ORDER RESTRICTED | P<0.001 ** (e) (e) (e) (e) |
|=================================================================================================================================|
Date: 03/03/04 EXPERIMENT: 96020 TEST: 01 Page 14
Statistical Analysis of Non-neoplastic Lesions in Rats(SPRAGUE-DAWLEY) - TEF EVALUATION (BINARY MIXTURE; PCB 126
Terminal Sacrifice at 105 weeks
|=================================================================================================================================|
| | |
| | Females |
|Dose | 0 NG / 10 NG / 100 NG / 300 NG / 1000 NG/ |
| | 0 UG 10 UG 100 UG 300 UG 1000 UG |
|=================================================================================================================================|
| |
|Kidney |
| Pigmentation |
| |
| |
|---------------------------------------------------------------------------------------------------------------------------------|
|LESION RATES | |
|----------- | |
|OVERALL (a) | 0/53 (0%) 1/53 (2%) 3/52 (6%) 7/52 (13%) 35/51 (69%) |
|POLY-3 RATE (b) | 0/38.18 1/37.40 3/39.12 7/38.16 35/40.29 |
|POLY-3 PERCENT (g) | 0.0% 2.7% 7.7% 18.3% 86.9% |
|TERMINAL (d) | 0/22 (0%) 1/21 (5%) 1/22 (5%) 6/24 (25%) 23/24 (96%) |
|FIRST INCIDENCE | --- 729 (T) 664 451 563 |
|-------------------| |
|STATISTICAL TESTS | |
|-------------------| |
|LIFE TABLE | P<0.001 ** P=0.491 P=0.130 P=0.011 * P<0.001 ** |
|POLY 3 | P<0.001 ** P=0.496 P=0.122 P=0.007 ** P<0.001 ** |
|POLY 1.5 | P<0.001 ** P=0.496 P=0.119 P=0.007 ** P<0.001 ** |
|POLY 6 | P<0.001 ** P=0.497 P=0.125 P=0.007 ** P<0.001 ** |
|LOGISTIC REGRESSION| P<0.001 ** P=0.491 P=0.124 P=0.008 ** P<0.001 ** |
|COCH-ARM / FISHERS | P<0.001 ** P=0.500 P=0.118 P=0.006 ** P<0.001 ** |
|ORDER RESTRICTED | P<0.001 ** (e) (e) (e) (e) |
|=================================================================================================================================|
| | |
| | Females |
|Dose | 0 NG / 10 NG / 100 NG / 300 NG / 1000 NG/ |
| | 0 UG 10 UG 100 UG 300 UG 1000 UG |
|=================================================================================================================================|
| |
|Kidney: Pelvis |
| Dilatation |
| |
| |
|---------------------------------------------------------------------------------------------------------------------------------|
|LESION RATES | |
|----------- | |
|OVERALL (a) | 1/53 (2%) 0/53 (0%) 0/52 (0%) 2/52 (4%) 1/51 (2%) |
|POLY-3 RATE (b) | 1/38.18 0/37.40 0/38.82 2/37.83 1/36.94 |
|POLY-3 PERCENT (g) | 2.6% 0.0% 0.0% 5.3% 2.7% |
|TERMINAL (d) | 1/22 (5%) 0/21 (0%) 0/22 (0%) 0/24 (0%) 0/24 (0%) |
|FIRST INCIDENCE | 729 (T) --- --- 618 499 |
|-------------------| |
|STATISTICAL TESTS | |
|-------------------| |
|LIFE TABLE | P=0.434 P=0.509N P=0.500N P=0.506 P=0.753N |
|POLY 3 | P=0.425 P=0.504N P=0.497N P=0.497 P=0.754 |
|POLY 1.5 | P=0.420 P=0.504N P=0.499N P=0.493 P=0.750 |
|POLY 6 | P=0.432 P=0.503N P=0.494N P=0.504 P=0.760 |
|LOGISTIC REGRESSION| P=0.422 (e) (e) P=0.494 P=0.755 |
|COCH-ARM / FISHERS | P=0.424 P=0.500N P=0.505N P=0.493 P=0.743 |
|ORDER RESTRICTED | P=0.297 (e) (e) (e) (e) |
|=================================================================================================================================|
Date: 03/03/04 EXPERIMENT: 96020 TEST: 01 Page 15
Statistical Analysis of Non-neoplastic Lesions in Rats(SPRAGUE-DAWLEY) - TEF EVALUATION (BINARY MIXTURE; PCB 126
Terminal Sacrifice at 105 weeks
|=================================================================================================================================|
| | |
| | Females |
|Dose | 0 NG / 10 NG / 100 NG / 300 NG / 1000 NG/ |
| | 0 UG 10 UG 100 UG 300 UG 1000 UG |
|=================================================================================================================================|
| |
|Kidney: Pelvis |
| Inflammation |
| |
| |
|---------------------------------------------------------------------------------------------------------------------------------|
|LESION RATES | |
|----------- | |
|OVERALL (a) | 3/53 (6%) 0/53 (0%) 4/52 (8%) 3/52 (6%) 5/51 (10%) |
|POLY-3 RATE (b) | 3/39.42 0/37.40 4/39.96 3/38.07 5/37.95 |
|POLY-3 PERCENT (g) | 7.6% 0.0% 10.0% 7.9% 13.2% |
|TERMINAL (d) | 1/22 (5%) 0/21 (0%) 1/22 (5%) 2/24 (8%) 2/24 (8%) |
|FIRST INCIDENCE | 499 --- 531 499 485 |
|-------------------| |
|STATISTICAL TESTS | |
|-------------------| |
|LIFE TABLE | P=0.119 P=0.128N P=0.500 P=0.637N P=0.364 |
|POLY 3 | P=0.105 P=0.127N P=0.507 P=0.648 P=0.334 |
|POLY 1.5 | P=0.100 P=0.125N P=0.500 P=0.648 P=0.327 |
|POLY 6 | P=0.111 P=0.129N P=0.516 P=0.649 P=0.343 |
|LOGISTIC REGRESSION| P=0.100 P=0.117N P=0.486 P=0.654 P=0.340 |
|COCH-ARM / FISHERS | P=0.100 P=0.121N P=0.489 P=0.652 P=0.336 |
|ORDER RESTRICTED | P=0.097 (e) (e) (e) (e) |
|=================================================================================================================================|
| | |
| | Females |
|Dose | 0 NG / 10 NG / 100 NG / 300 NG / 1000 NG/ |
| | 0 UG 10 UG 100 UG 300 UG 1000 UG |
|=================================================================================================================================|
| |
|Kidney: Renal Tubule |
| Degeneration |
| |
| |
|---------------------------------------------------------------------------------------------------------------------------------|
|LESION RATES | |
|----------- | |
|OVERALL (a) | 0/53 (0%) 0/53 (0%) 1/52 (2%) 2/52 (4%) 1/51 (2%) |
|POLY-3 RATE (b) | 0/38.18 0/37.40 1/38.82 2/37.67 1/36.26 |
|POLY-3 PERCENT (g) | 0.0% 0.0% 2.6% 5.3% 2.8% |
|TERMINAL (d) | 0/22 (0%) 0/21 (0%) 1/22 (5%) 1/24 (4%) 1/24 (4%) |
|FIRST INCIDENCE | --- --- 729 (T) 654 729 (T) |
|-------------------| |
|STATISTICAL TESTS | |
|-------------------| |
|LIFE TABLE | P=0.397 (e) P=0.500 P=0.239 P=0.517 |
|POLY 3 | P=0.368 (e) P=0.503 P=0.233 P=0.490 |
|POLY 1.5 | P=0.365 (e) P=0.501 P=0.232 P=0.488 |
|POLY 6 | P=0.372 (e) P=0.506 P=0.237 P=0.492 |
|LOGISTIC REGRESSION| P=0.371 (e) P=0.500 P=0.233 P=0.517 |
|COCH-ARM / FISHERS | P=0.372 (e) P=0.495 P=0.243 P=0.490 |
|ORDER RESTRICTED | P=0.190 (e) (e) (e) (e) |
|=================================================================================================================================|
Date: 03/03/04 EXPERIMENT: 96020 TEST: 01 Page 16
Statistical Analysis of Non-neoplastic Lesions in Rats(SPRAGUE-DAWLEY) - TEF EVALUATION (BINARY MIXTURE; PCB 126
Terminal Sacrifice at 105 weeks
|=================================================================================================================================|
| | |
| | Females |
|Dose | 0 NG / 10 NG / 100 NG / 300 NG / 1000 NG/ |
| | 0 UG 10 UG 100 UG 300 UG 1000 UG |
|=================================================================================================================================|
| |
|Kidney: Transitional Epithelium |
| Hyperplasia |
| |
| |
|---------------------------------------------------------------------------------------------------------------------------------|
|LESION RATES | |
|----------- | |
|OVERALL (a) | 2/53 (4%) 2/53 (4%) 4/52 (8%) 11/52 (21%) 6/51 (12%) |
|POLY-3 RATE (b) | 2/38.18 2/38.38 4/39.07 11/39.29 6/38.65 |
|POLY-3 PERCENT (g) | 5.2% 5.2% 10.2% 28.0% 15.5% |
|TERMINAL (d) | 2/22 (9%) 1/21 (5%) 3/22 (14%) 7/24 (29%) 2/24 (8%) |
|FIRST INCIDENCE | 729 (T) 178 664 539 485 |
|-------------------| |
|STATISTICAL TESTS | |
|-------------------| |
|LIFE TABLE | P=0.118 P=0.682 P=0.330 P=0.012 * P=0.148 |
|POLY 3 | P=0.093 P=0.693N P=0.346 P=0.007 ** P=0.133 |
|POLY 1.5 | P=0.081 P=0.694 P=0.339 P=0.006 ** P=0.124 |
|POLY 6 | P=0.110 P=0.690N P=0.354 P=0.008 ** P=0.147 |
|LOGISTIC REGRESSION| P=0.080 P=0.688N P=0.352 P=0.007 ** P=0.121 |
|COCH-ARM / FISHERS | P=0.084 P=0.691N P=0.330 P=0.007 ** P=0.123 |
|ORDER RESTRICTED | P=0.018 * (e) (e) (e) (e) |
|=================================================================================================================================|
| | |
| | Females |
|Dose | 0 NG / 10 NG / 100 NG / 300 NG / 1000 NG/ |
| | 0 UG 10 UG 100 UG 300 UG 1000 UG |
|=================================================================================================================================|
| |
|Liver |
| Angiectasis |
| |
| |
|---------------------------------------------------------------------------------------------------------------------------------|
|LESION RATES | |
|----------- | |
|OVERALL (a) | 3/53 (6%) 1/53 (2%) 1/52 (2%) 2/52 (4%) 5/51 (10%) |
|POLY-3 RATE (b) | 3/38.74 1/37.40 1/38.82 2/37.66 5/36.26 |
|POLY-3 PERCENT (g) | 7.7% 2.7% 2.6% 5.3% 13.8% |
|TERMINAL (d) | 2/22 (9%) 1/21 (5%) 1/22 (5%) 1/24 (4%) 5/24 (21%) |
|FIRST INCIDENCE | 556 729 (T) 729 (T) 659 729 (T) |
|-------------------| |
|STATISTICAL TESTS | |
|-------------------| |
|LIFE TABLE | P=0.073 P=0.320N P=0.303N P=0.487N P=0.395 |
|POLY 3 | P=0.048 * P=0.317N P=0.303N P=0.513N P=0.318 |
|POLY 1.5 | P=0.049 * P=0.315N P=0.306N P=0.513N P=0.319 |
|POLY 6 | P=0.048 * P=0.317N P=0.302N P=0.510N P=0.318 |
|LOGISTIC REGRESSION| P=0.050 P=0.311N P=0.299N P=0.509N P=0.334 |
|COCH-ARM / FISHERS | P=0.053 P=0.309N P=0.316N P=0.509N P=0.336 |
|ORDER RESTRICTED | P=0.070 (e) (e) (e) (e) |
|=================================================================================================================================|
Date: 03/03/04 EXPERIMENT: 96020 TEST: 01 Page 17
Statistical Analysis of Non-neoplastic Lesions in Rats(SPRAGUE-DAWLEY) - TEF EVALUATION (BINARY MIXTURE; PCB 126
Terminal Sacrifice at 105 weeks
|=================================================================================================================================|
| | |
| | Females |
|Dose | 0 NG / 10 NG / 100 NG / 300 NG / 1000 NG/ |
| | 0 UG 10 UG 100 UG 300 UG 1000 UG |
|=================================================================================================================================|
| |
|Liver |
| Basophilic Focus |
| |
| |
|---------------------------------------------------------------------------------------------------------------------------------|
|LESION RATES | |
|----------- | |
|OVERALL (a) | 22/53 (42%) 22/53 (42%) 14/52 (27%) 3/52 (6%) 6/51 (12%) |
|POLY-3 RATE (b) | 22/43.23 22/40.41 14/41.62 3/37.45 6/36.96 |
|POLY-3 PERCENT (g) | 50.9% 54.5% 33.6% 8.0% 16.2% |
|TERMINAL (d) | 9/22 (41%) 14/21 (67%) 7/22 (32%) 2/24 (8%) 5/24 (21%) |
|FIRST INCIDENCE | 377 296 254 715 491 |
|-------------------| |
|STATISTICAL TESTS | |
|-------------------| |
|LIFE TABLE | P<0.001N** P=0.530 P=0.092N P<0.001N** P<0.001N** |
|POLY 3 | P<0.001N** P=0.456 P=0.075N P<0.001N** P<0.001N** |
|POLY 1.5 | P<0.001N** P=0.496 P=0.075N P<0.001N** P<0.001N** |
|POLY 6 | P<0.001N** P=0.418 P=0.081N P<0.001N** P<0.001N** |
|LOGISTIC REGRESSION| P<0.001N** P=0.547 P=0.077N P<0.001N** P<0.001N** |
|COCH-ARM / FISHERS | P<0.001N** P=0.578N P=0.085N P<0.001N** P<0.001N** |
|ORDER RESTRICTED | P<0.001N** (e) (e) (e) (e) |
|=================================================================================================================================|
| | |
| | Females |
|Dose | 0 NG / 10 NG / 100 NG / 300 NG / 1000 NG/ |
| | 0 UG 10 UG 100 UG 300 UG 1000 UG |
|=================================================================================================================================|
| |
|Liver |
| Cholangiofibrosis |
| |
| |
|---------------------------------------------------------------------------------------------------------------------------------|
|LESION RATES | |
|----------- | |
|OVERALL (a) | 0/53 (0%) 1/53 (2%) 0/52 (0%) 7/52 (13%) 39/51 (76%) |
|POLY-3 RATE (b) | 0/38.18 1/38.22 0/38.82 7/37.86 39/41.56 |
|POLY-3 PERCENT (g) | 0.0% 2.6% 0.0% 18.5% 93.8% |
|TERMINAL (d) | 0/22 (0%) 0/21 (0%) 0/22 (0%) 5/24 (21%) 24/24 (100%) |
|FIRST INCIDENCE | --- 407 --- 612 540 |
|-------------------| |
|STATISTICAL TESTS | |
|-------------------| |
|LIFE TABLE | P<0.001 ** P=0.483 (e) P=0.012 * P<0.001 ** |
|POLY 3 | P<0.001 ** P=0.500 (e) P=0.007 ** P<0.001 ** |
|POLY 1.5 | P<0.001 ** P=0.498 (e) P=0.007 ** P<0.001 ** |
|POLY 6 | P<0.001 ** P=0.503 (e) P=0.007 ** P<0.001 ** |
|LOGISTIC REGRESSION| P<0.001 ** P=0.527 (e) P=0.008 ** P<0.001 ** |
|COCH-ARM / FISHERS | P<0.001 ** P=0.500 (e) P=0.006 ** P<0.001 ** |
|ORDER RESTRICTED | P<0.001 ** (e) (e) (e) (e) |
|=================================================================================================================================|
Date: 03/03/04 EXPERIMENT: 96020 TEST: 01 Page 18
Statistical Analysis of Non-neoplastic Lesions in Rats(SPRAGUE-DAWLEY) - TEF EVALUATION (BINARY MIXTURE; PCB 126
Terminal Sacrifice at 105 weeks
|=================================================================================================================================|
| | |
| | Females |
|Dose | 0 NG / 10 NG / 100 NG / 300 NG / 1000 NG/ |
| | 0 UG 10 UG 100 UG 300 UG 1000 UG |
|=================================================================================================================================|
| |
|Liver |
| Clear Cell Focus |
| |
| |
|---------------------------------------------------------------------------------------------------------------------------------|
|LESION RATES | |
|----------- | |
|OVERALL (a) | 9/53 (17%) 3/53 (6%) 3/52 (6%) 3/52 (6%) 1/51 (2%) |
|POLY-3 RATE (b) | 9/38.43 3/37.40 3/38.82 3/37.39 1/37.26 |
|POLY-3 PERCENT (g) | 23.4% 8.0% 7.7% 8.0% 2.7% |
|TERMINAL (d) | 8/22 (36%) 3/21 (14%) 3/22 (14%) 3/24 (13%) 0/24 (0%) |
|FIRST INCIDENCE | 664 729 (T) 729 (T) 729 (T) 71 |
|-------------------| |
|STATISTICAL TESTS | |
|-------------------| |
|LIFE TABLE | P=0.025N* P=0.062N P=0.053N P=0.039N* P=0.007N** |
|POLY 3 | P=0.036N* P=0.060N P=0.052N P=0.060N P=0.008N** |
|POLY 1.5 | P=0.038N* P=0.062N P=0.057N P=0.063N P=0.009N** |
|POLY 6 | P=0.034N* P=0.057N P=0.049N* P=0.056N P=0.007N** |
|LOGISTIC REGRESSION| P=0.042N* P=0.054N P=0.043N* P=0.045N* P=0.012N* |
|COCH-ARM / FISHERS | P=0.043N* P=0.061N P=0.066N P=0.066N P=0.009N** |
|ORDER RESTRICTED | P=0.002N** (e) (e) (e) (e) |
|=================================================================================================================================|
| | |
| | Females |
|Dose | 0 NG / 10 NG / 100 NG / 300 NG / 1000 NG/ |
| | 0 UG 10 UG 100 UG 300 UG 1000 UG |
|=================================================================================================================================|
| |
|Liver |
| Eosinophilic Focus |
| |
| |
|---------------------------------------------------------------------------------------------------------------------------------|
|LESION RATES | |
|----------- | |
|OVERALL (a) | 14/53 (26%) 16/53 (30%) 30/52 (58%) 40/52 (77%) 18/51 (35%) |
|POLY-3 RATE (b) | 14/42.00 16/40.12 30/45.64 40/47.53 18/42.64 |
|POLY-3 PERCENT (g) | 33.3% 39.9% 65.7% 84.2% 42.2% |
|TERMINAL (d) | 4/22 (18%) 10/21 (48%) 11/22 (50%) 18/24 (75%) 5/24 (21%) |
|FIRST INCIDENCE | 451 296 254 330 169 |
|-------------------| |
|STATISTICAL TESTS | |
|-------------------| |
|LIFE TABLE | P=0.494N P=0.378 P=0.010 * P<0.001 ** P=0.297 |
|POLY 3 | P=0.450N P=0.347 P<0.001 ** P<0.001 ** P=0.265 |
|POLY 1.5 | P=0.544N P=0.373 P<0.001 ** P<0.001 ** P=0.236 |
|POLY 6 | P=0.344N P=0.312 P=0.002 ** P<0.001 ** P=0.303 |
|LOGISTIC REGRESSION| P=0.465 P=0.396 P<0.001 ** P<0.001 ** P=0.222 |
|COCH-ARM / FISHERS | P=0.485 P=0.415 P<0.001 ** P<0.001 ** P=0.221 |
|ORDER RESTRICTED | P<0.001 ** (e) (e) (e) (e) |
|=================================================================================================================================|
Date: 03/03/04 EXPERIMENT: 96020 TEST: 01 Page 19
Statistical Analysis of Non-neoplastic Lesions in Rats(SPRAGUE-DAWLEY) - TEF EVALUATION (BINARY MIXTURE; PCB 126
Terminal Sacrifice at 105 weeks
|=================================================================================================================================|
| | |
| | Females |
|Dose | 0 NG / 10 NG / 100 NG / 300 NG / 1000 NG/ |
| | 0 UG 10 UG 100 UG 300 UG 1000 UG |
|=================================================================================================================================|
| |
|Liver |
| Fatty Change Diffuse |
| |
| |
|---------------------------------------------------------------------------------------------------------------------------------|
|LESION RATES | |
|----------- | |
|OVERALL (a) | 3/53 (6%) 1/53 (2%) 9/52 (17%) 31/52 (60%) 38/51 (75%) |
|POLY-3 RATE (b) | 3/39.19 1/37.87 9/40.34 31/45.69 38/47.97 |
|POLY-3 PERCENT (g) | 7.7% 2.6% 22.3% 67.8% 79.2% |
|TERMINAL (d) | 1/22 (5%) 0/21 (0%) 6/22 (27%) 15/24 (63%) 16/24 (67%) |
|FIRST INCIDENCE | 449 589 125 254 71 |
|-------------------| |
|STATISTICAL TESTS | |
|-------------------| |
|LIFE TABLE | P<0.001 ** P=0.322N P=0.068 P<0.001 ** P<0.001 ** |
|POLY 3 | P<0.001 ** P=0.317N P=0.062 P<0.001 ** P<0.001 ** |
|POLY 1.5 | P<0.001 ** P=0.315N P=0.061 P<0.001 ** P<0.001 ** |
|POLY 6 | P<0.001 ** P=0.315N P=0.062 P<0.001 ** P<0.001 ** |
|LOGISTIC REGRESSION| P<0.001 ** P=0.302N P=0.059 P<0.001 ** P<0.001 ** |
|COCH-ARM / FISHERS | P<0.001 ** P=0.309N P=0.057 P<0.001 ** P<0.001 ** |
|ORDER RESTRICTED | P<0.001 ** (e) (e) (e) (e) |
|=================================================================================================================================|
| | |
| | Females |
|Dose | 0 NG / 10 NG / 100 NG / 300 NG / 1000 NG/ |
| | 0 UG 10 UG 100 UG 300 UG 1000 UG |
|=================================================================================================================================|
| |
|Liver |
| Fatty Change Focal |
| |
| |
|---------------------------------------------------------------------------------------------------------------------------------|
|LESION RATES | |
|----------- | |
|OVERALL (a) | 3/53 (6%) 4/53 (8%) 7/52 (13%) 1/52 (2%) 12/51 (24%) |
|POLY-3 RATE (b) | 3/38.27 4/37.52 7/39.16 1/37.83 12/37.11 |
|POLY-3 PERCENT (g) | 7.8% 10.7% 17.9% 2.6% 32.3% |
|TERMINAL (d) | 2/22 (9%) 3/21 (14%) 5/22 (23%) 0/24 (0%) 9/24 (38%) |
|FIRST INCIDENCE | 708 698 654 603 563 |
|-------------------| |
|STATISTICAL TESTS | |
|-------------------| |
|LIFE TABLE | P=0.005 ** P=0.472 P=0.169 P=0.288N P=0.018 * |
|POLY 3 | P<0.001 ** P=0.489 P=0.162 P=0.308N P=0.007 ** |
|POLY 1.5 | P<0.001 ** P=0.489 P=0.158 P=0.312N P=0.007 ** |
|POLY 6 | P<0.001 ** P=0.494 P=0.167 P=0.301N P=0.007 ** |
|LOGISTIC REGRESSION| P=0.002 ** P=0.493 P=0.167 P=0.310N P=0.008 ** |
|COCH-ARM / FISHERS | P=0.002 ** P=0.500 P=0.152 P=0.316N P=0.009 ** |
|ORDER RESTRICTED | P<0.001 ** (e) (e) (e) (e) |
|=================================================================================================================================|
Date: 03/03/04 EXPERIMENT: 96020 TEST: 01 Page 20
Statistical Analysis of Non-neoplastic Lesions in Rats(SPRAGUE-DAWLEY) - TEF EVALUATION (BINARY MIXTURE; PCB 126
Terminal Sacrifice at 105 weeks
|=================================================================================================================================|
| | |
| | Females |
|Dose | 0 NG / 10 NG / 100 NG / 300 NG / 1000 NG/ |
| | 0 UG 10 UG 100 UG 300 UG 1000 UG |
|=================================================================================================================================|
| |
|Liver |
| Hematopoietic Cell Proliferation |
| |
| |
|---------------------------------------------------------------------------------------------------------------------------------|
|LESION RATES | |
|----------- | |
|OVERALL (a) | 27/53 (51%) 29/53 (55%) 30/52 (58%) 19/52 (37%) 11/51 (22%) |
|POLY-3 RATE (b) | 27/49.38 29/45.61 30/48.78 19/44.94 11/40.88 |
|POLY-3 PERCENT (g) | 54.7% 63.6% 61.5% 42.3% 26.9% |
|TERMINAL (d) | 5/22 (23%) 11/21 (52%) 8/22 (36%) 6/24 (25%) 5/24 (21%) |
|FIRST INCIDENCE | 85 167 254 142 169 |
|-------------------| |
|STATISTICAL TESTS | |
|-------------------| |
|LIFE TABLE | P<0.001N** P=0.406 P=0.422 P=0.143N P=0.007N** |
|POLY 3 | P<0.001N** P=0.247 P=0.314 P=0.156N P=0.005N** |
|POLY 1.5 | P<0.001N** P=0.298 P=0.308 P=0.130N P=0.003N** |
|POLY 6 | P<0.001N** P=0.205 P=0.310 P=0.189N P=0.012N* |
|LOGISTIC REGRESSION| P<0.001N** P=0.445 P=0.256 P=0.083N P<0.001N** |
|COCH-ARM / FISHERS | P<0.001N** P=0.423 P=0.309 P=0.098N P=0.002N** |
|ORDER RESTRICTED | P<0.001N** (e) (e) (e) (e) |
|=================================================================================================================================|
| | |
| | Females |
|Dose | 0 NG / 10 NG / 100 NG / 300 NG / 1000 NG/ |
| | 0 UG 10 UG 100 UG 300 UG 1000 UG |
|=================================================================================================================================|
| |
|Liver |
| Hepatodiaphragmatic Nodule |
| |
| |
|---------------------------------------------------------------------------------------------------------------------------------|
|LESION RATES | |
|----------- | |
|OVERALL (a) | 0/53 (0%) 2/53 (4%) 0/52 (0%) 0/52 (0%) 0/51 (0%) |
|POLY-3 RATE (b) | 0/38.18 2/38.54 0/38.82 0/37.39 0/36.26 |
|POLY-3 PERCENT (g) | 0.0% 5.2% 0.0% 0.0% 0.0% |
|TERMINAL (d) | 0/22 (0%) 0/21 (0%) 0/22 (0%) 0/24 (0%) 0/24 (0%) |
|FIRST INCIDENCE | --- 178 --- --- --- |
|-------------------| |
|STATISTICAL TESTS | |
|-------------------| |
|LIFE TABLE | P=0.360N P=0.252 (e) (e) (e) |
|POLY 3 | P=0.364N P=0.238 (e) (e) (e) |
|POLY 1.5 | P=0.365N P=0.237 (e) (e) (e) |
|POLY 6 | P=0.361N P=0.242 (e) (e) (e) |
|LOGISTIC REGRESSION| P=0.321N P=0.261 (e) (e) (e) |
|COCH-ARM / FISHERS | P=0.363N P=0.248 (e) (e) (e) |
|ORDER RESTRICTED | P=0.229N (e) (e) (e) (e) |
|=================================================================================================================================|
Date: 03/03/04 EXPERIMENT: 96020 TEST: 01 Page 21
Statistical Analysis of Non-neoplastic Lesions in Rats(SPRAGUE-DAWLEY) - TEF EVALUATION (BINARY MIXTURE; PCB 126
Terminal Sacrifice at 105 weeks
|=================================================================================================================================|
| | |
| | Females |
|Dose | 0 NG / 10 NG / 100 NG / 300 NG / 1000 NG/ |
| | 0 UG 10 UG 100 UG 300 UG 1000 UG |
|=================================================================================================================================|
| |
|Liver |
| Hyperplasia |
| |
| |
|---------------------------------------------------------------------------------------------------------------------------------|
|LESION RATES | |
|----------- | |
|OVERALL (a) | 0/53 (0%) 0/53 (0%) 2/52 (4%) 24/52 (46%) 42/51 (82%) |
|POLY-3 RATE (b) | 0/38.18 0/37.40 2/39.12 24/39.96 42/43.59 |
|POLY-3 PERCENT (g) | 0.0% 0.0% 5.1% 60.1% 96.4% |
|TERMINAL (d) | 0/22 (0%) 0/21 (0%) 0/22 (0%) 16/24 (67%) 24/24 (100%) |
|FIRST INCIDENCE | --- --- 664 552 477 |
|-------------------| |
|STATISTICAL TESTS | |
|-------------------| |
|LIFE TABLE | P<0.001 ** (e) P=0.250 P<0.001 ** P<0.001 ** |
|POLY 3 | P<0.001 ** (e) P=0.242 P<0.001 ** P<0.001 ** |
|POLY 1.5 | P<0.001 ** (e) P=0.238 P<0.001 ** P<0.001 ** |
|POLY 6 | P<0.001 ** (e) P=0.246 P<0.001 ** P<0.001 ** |
|LOGISTIC REGRESSION| P<0.001 ** (e) P=0.241 P<0.001 ** P<0.001 ** |
|COCH-ARM / FISHERS | P<0.001 ** (e) P=0.243 P<0.001 ** P<0.001 ** |
|ORDER RESTRICTED | P<0.001 ** (e) (e) (e) (e) |
|=================================================================================================================================|
| | |
| | Females |
|Dose | 0 NG / 10 NG / 100 NG / 300 NG / 1000 NG/ |
| | 0 UG 10 UG 100 UG 300 UG 1000 UG |
|=================================================================================================================================|
| |
|Liver |
| Inflammation |
| |
| |
|---------------------------------------------------------------------------------------------------------------------------------|
|LESION RATES | |
|----------- | |
|OVERALL (a) | 44/53 (83%) 41/53 (77%) 46/52 (88%) 48/52 (92%) 46/51 (90%) |
|POLY-3 RATE (b) | 44/50.14 41/48.11 46/50.19 48/50.71 46/49.13 |
|POLY-3 PERCENT (g) | 87.8% 85.2% 91.7% 94.7% 93.6% |
|TERMINAL (d) | 19/22 (86%) 18/21 (86%) 20/22 (91%) 23/24 (96%) 23/24 (96%) |
|FIRST INCIDENCE | 85 178 125 254 169 |
|-------------------| |
|STATISTICAL TESTS | |
|-------------------| |
|LIFE TABLE | P=0.415 P=0.456N P=0.481 P=0.407 P=0.479 |
|POLY 3 | P=0.140 P=0.469N P=0.369 P=0.175 P=0.240 |
|POLY 1.5 | P=0.103 P=0.441N P=0.326 P=0.129 P=0.195 |
|POLY 6 | P=0.183 P=0.467N P=0.417 P=0.238 P=0.302 |
|LOGISTIC REGRESSION| P=0.082 P=0.333N P=0.309 P=0.123 P=0.203 |
|COCH-ARM / FISHERS | P=0.096 P=0.313N P=0.303 P=0.125 P=0.217 |
|ORDER RESTRICTED | P=0.133 (e) (e) (e) (e) |
|=================================================================================================================================|
Date: 03/03/04 EXPERIMENT: 96020 TEST: 01 Page 22
Statistical Analysis of Non-neoplastic Lesions in Rats(SPRAGUE-DAWLEY) - TEF EVALUATION (BINARY MIXTURE; PCB 126
Terminal Sacrifice at 105 weeks
|=================================================================================================================================|
| | |
| | Females |
|Dose | 0 NG / 10 NG / 100 NG / 300 NG / 1000 NG/ |
| | 0 UG 10 UG 100 UG 300 UG 1000 UG |
|=================================================================================================================================|
| |
|Liver |
| Mixed Cell Focus |
| |
| |
|---------------------------------------------------------------------------------------------------------------------------------|
|LESION RATES | |
|----------- | |
|OVERALL (a) | 26/53 (49%) 22/53 (42%) 30/52 (58%) 26/52 (50%) 3/51 (6%) |
|POLY-3 RATE (b) | 26/43.18 22/40.56 30/44.57 26/38.98 3/36.26 |
|POLY-3 PERCENT (g) | 60.2% 54.2% 67.3% 66.7% 8.3% |
|TERMINAL (d) | 16/22 (73%) 16/21 (76%) 17/22 (77%) 23/24 (96%) 3/24 (13%) |
|FIRST INCIDENCE | 377 330 254 499 729 (T) |
|-------------------| |
|STATISTICAL TESTS | |
|-------------------| |
|LIFE TABLE | P<0.001N** P=0.343N P=0.315 P=0.456N P<0.001N** |
|POLY 3 | P<0.001N** P=0.363N P=0.309 P=0.341 P<0.001N** |
|POLY 1.5 | P<0.001N** P=0.335N P=0.285 P=0.424 P<0.001N** |
|POLY 6 | P<0.001N** P=0.401N P=0.338 P=0.238 P<0.001N** |
|LOGISTIC REGRESSION| P<0.001N** P=0.303N P=0.272 P=0.536 P<0.001N** |
|COCH-ARM / FISHERS | P<0.001N** P=0.279N P=0.245 P=0.539 P<0.001N** |
|ORDER RESTRICTED | P<0.001N** (e) (e) (e) (e) |
|=================================================================================================================================|
| | |
| | Females |
|Dose | 0 NG / 10 NG / 100 NG / 300 NG / 1000 NG/ |
| | 0 UG 10 UG 100 UG 300 UG 1000 UG |
|=================================================================================================================================|
| |
|Liver |
| Necrosis |
| |
| |
|---------------------------------------------------------------------------------------------------------------------------------|
|LESION RATES | |
|----------- | |
|OVERALL (a) | 4/53 (8%) 8/53 (15%) 5/52 (10%) 4/52 (8%) 20/51 (39%) |
|POLY-3 RATE (b) | 4/39.53 8/40.10 5/40.50 4/38.13 20/44.06 |
|POLY-3 PERCENT (g) | 10.1% 20.0% 12.4% 10.5% 45.4% |
|TERMINAL (d) | 0/22 (0%) 1/21 (5%) 0/22 (0%) 2/24 (8%) 8/24 (33%) |
|FIRST INCIDENCE | 533 499 469 552 71 |
|-------------------| |
|STATISTICAL TESTS | |
|-------------------| |
|LIFE TABLE | P<0.001 ** P=0.186 P=0.514 P=0.636 P<0.001 ** |
|POLY 3 | P<0.001 ** P=0.179 P=0.515 P=0.625 P<0.001 ** |
|POLY 1.5 | P<0.001 ** P=0.173 P=0.506 P=0.626 P<0.001 ** |
|POLY 6 | P<0.001 ** P=0.191 P=0.521 P=0.624 P<0.001 ** |
|LOGISTIC REGRESSION| P<0.001 ** P=0.178 P=0.485 P=0.632 P<0.001 ** |
|COCH-ARM / FISHERS | P<0.001 ** P=0.179 P=0.488 P=0.631 P<0.001 ** |
|ORDER RESTRICTED | P<0.001 ** (e) (e) (e) (e) |
|=================================================================================================================================|
Date: 03/03/04 EXPERIMENT: 96020 TEST: 01 Page 23
Statistical Analysis of Non-neoplastic Lesions in Rats(SPRAGUE-DAWLEY) - TEF EVALUATION (BINARY MIXTURE; PCB 126
Terminal Sacrifice at 105 weeks
|=================================================================================================================================|
| | |
| | Females |
|Dose | 0 NG / 10 NG / 100 NG / 300 NG / 1000 NG/ |
| | 0 UG 10 UG 100 UG 300 UG 1000 UG |
|=================================================================================================================================|
| |
|Liver |
| Pigmentation |
| |
| |
|---------------------------------------------------------------------------------------------------------------------------------|
|LESION RATES | |
|----------- | |
|OVERALL (a) | 2/53 (4%) 5/53 (9%) 38/52 (73%) 50/52 (96%) 50/51 (98%) |
|POLY-3 RATE (b) | 2/38.18 5/39.17 38/45.72 50/50.05 50/50.00 |
|POLY-3 PERCENT (g) | 5.2% 12.8% 83.1% 99.9% 100.0% |
|TERMINAL (d) | 2/22 (9%) 1/21 (5%) 20/22 (91%) 24/24 (100%) 24/24 (100%) |
|FIRST INCIDENCE | 729 (T) 407 458 310 169 |
|-------------------| |
|STATISTICAL TESTS | |
|-------------------| |
|LIFE TABLE | P<0.001 ** P=0.219 P<0.001 ** P<0.001 ** P<0.001 ** |
|POLY 3 | P<0.001 ** P=0.224 P<0.001 ** P<0.001 ** P<0.001 ** |
|POLY 1.5 | P<0.001 ** P=0.217 P<0.001 ** P<0.001 ** P<0.001 ** |
|POLY 6 | P<0.001 ** P=0.237 P<0.001 ** P<0.001 ** P<0.001 ** |
|LOGISTIC REGRESSION| P<0.001 ** P=0.213 P<0.001 ** P<0.001 ** P<0.001 ** |
|COCH-ARM / FISHERS | P<0.001 ** P=0.219 P<0.001 ** P<0.001 ** P<0.001 ** |
|ORDER RESTRICTED | P<0.001 ** (e) (e) (e) (e) |
|=================================================================================================================================|
| | |
| | Females |
|Dose | 0 NG / 10 NG / 100 NG / 300 NG / 1000 NG/ |
| | 0 UG 10 UG 100 UG 300 UG 1000 UG |
|=================================================================================================================================|
| |
|Liver |
| Toxic Hepatopathy |
| |
| |
|---------------------------------------------------------------------------------------------------------------------------------|
|LESION RATES | |
|----------- | |
|OVERALL (a) | 0/53 (0%) 2/53 (4%) 34/52 (65%) 48/52 (92%) 49/51 (96%) |
|POLY-3 RATE (b) | 0/38.18 2/38.48 34/45.02 48/48.25 49/49.02 |
|POLY-3 PERCENT (g) | 0.0% 5.2% 75.5% 99.5% 100.0% |
|TERMINAL (d) | 0/22 (0%) 0/21 (0%) 17/22 (77%) 24/24 (100%) 24/24 (100%) |
|FIRST INCIDENCE | --- 407 461 330 169 |
|-------------------| |
|STATISTICAL TESTS | |
|-------------------| |
|LIFE TABLE | P<0.001 ** P=0.231 P<0.001 ** P<0.001 ** P<0.001 ** |
|POLY 3 | P<0.001 ** P=0.238 P<0.001 ** P<0.001 ** P<0.001 ** |
|POLY 1.5 | P<0.001 ** P=0.236 P<0.001 ** P<0.001 ** P<0.001 ** |
|POLY 6 | P<0.001 ** P=0.242 P<0.001 ** P<0.001 ** P<0.001 ** |
|LOGISTIC REGRESSION| P<0.001 ** P=0.249 P<0.001 ** P<0.001 ** P<0.001 ** |
|COCH-ARM / FISHERS | P<0.001 ** P=0.248 P<0.001 ** P<0.001 ** P<0.001 ** |
|ORDER RESTRICTED | P<0.001 ** (e) (e) (e) (e) |
|=================================================================================================================================|
Date: 03/03/04 EXPERIMENT: 96020 TEST: 01 Page 24
Statistical Analysis of Non-neoplastic Lesions in Rats(SPRAGUE-DAWLEY) - TEF EVALUATION (BINARY MIXTURE; PCB 126
Terminal Sacrifice at 105 weeks
|=================================================================================================================================|
| | |
| | Females |
|Dose | 0 NG / 10 NG / 100 NG / 300 NG / 1000 NG/ |
| | 0 UG 10 UG 100 UG 300 UG 1000 UG |
|=================================================================================================================================|
| |
|Liver: Bile Duct |
| Cyst |
| |
| |
|---------------------------------------------------------------------------------------------------------------------------------|
|LESION RATES | |
|----------- | |
|OVERALL (a) | 4/53 (8%) 3/53 (6%) 1/52 (2%) 5/52 (10%) 23/51 (45%) |
|POLY-3 RATE (b) | 4/38.46 3/38.22 1/38.82 5/37.44 23/36.69 |
|POLY-3 PERCENT (g) | 10.4% 7.9% 2.6% 13.4% 62.7% |
|TERMINAL (d) | 3/22 (14%) 2/21 (10%) 1/22 (5%) 4/24 (17%) 20/24 (83%) |
|FIRST INCIDENCE | 654 407 729 (T) 719 654 |
|-------------------| |
|STATISTICAL TESTS | |
|-------------------| |
|LIFE TABLE | P<0.001 ** P=0.529N P=0.179N P=0.542 P<0.001 ** |
|POLY 3 | P<0.001 ** P=0.503N P=0.174N P=0.483 P<0.001 ** |
|POLY 1.5 | P<0.001 ** P=0.506N P=0.178N P=0.483 P<0.001 ** |
|POLY 6 | P<0.001 ** P=0.499N P=0.171N P=0.485 P<0.001 ** |
|LOGISTIC REGRESSION| P<0.001 ** P=0.510N P=0.166N P=0.510 P<0.001 ** |
|COCH-ARM / FISHERS | P<0.001 ** P=0.500N P=0.187N P=0.488 P<0.001 ** |
|ORDER RESTRICTED | P<0.001 ** (e) (e) (e) (e) |
|=================================================================================================================================|
| | |
| | Females |
|Dose | 0 NG / 10 NG / 100 NG / 300 NG / 1000 NG/ |
| | 0 UG 10 UG 100 UG 300 UG 1000 UG |
|=================================================================================================================================|
| |
|Liver: Bile Duct |
| Fibrosis |
| |
| |
|---------------------------------------------------------------------------------------------------------------------------------|
|LESION RATES | |
|----------- | |
|OVERALL (a) | 1/53 (2%) 3/53 (6%) 3/52 (6%) 4/52 (8%) 0/51 (0%) |
|POLY-3 RATE (b) | 1/38.41 3/38.00 3/39.97 4/38.64 0/36.26 |
|POLY-3 PERCENT (g) | 2.6% 7.9% 7.5% 10.4% 0.0% |
|TERMINAL (d) | 0/22 (0%) 2/21 (10%) 1/22 (5%) 1/24 (4%) 0/24 (0%) |
|FIRST INCIDENCE | 670 534 499 506 --- |
|-------------------| |
|STATISTICAL TESTS | |
|-------------------| |
|LIFE TABLE | P=0.159N P=0.304 P=0.315 P=0.188 P=0.507N |
|POLY 3 | P=0.174N P=0.300 P=0.319 P=0.178 P=0.511N |
|POLY 1.5 | P=0.175N P=0.299 P=0.311 P=0.175 P=0.512N |
|POLY 6 | P=0.173N P=0.303 P=0.326 P=0.186 P=0.510N |
|LOGISTIC REGRESSION| P=0.168N P=0.299 P=0.296 P=0.173 P=0.511N |
|COCH-ARM / FISHERS | P=0.167N P=0.309 P=0.302 P=0.176 P=0.510N |
|ORDER RESTRICTED | P=0.156N (e) (e) (e) (e) |
|=================================================================================================================================|
Date: 03/03/04 EXPERIMENT: 96020 TEST: 01 Page 25
Statistical Analysis of Non-neoplastic Lesions in Rats(SPRAGUE-DAWLEY) - TEF EVALUATION (BINARY MIXTURE; PCB 126
Terminal Sacrifice at 105 weeks
|=================================================================================================================================|
| | |
| | Females |
|Dose | 0 NG / 10 NG / 100 NG / 300 NG / 1000 NG/ |
| | 0 UG 10 UG 100 UG 300 UG 1000 UG |
|=================================================================================================================================|
| |
|Liver: Bile Duct |
| Hyperplasia |
| |
| |
|---------------------------------------------------------------------------------------------------------------------------------|
|LESION RATES | |
|----------- | |
|OVERALL (a) | 8/53 (15%) 2/53 (4%) 9/52 (17%) 29/52 (56%) 46/51 (90%) |
|POLY-3 RATE (b) | 8/39.10 2/37.94 9/40.07 29/42.15 46/46.37 |
|POLY-3 PERCENT (g) | 20.5% 5.3% 22.5% 68.8% 99.2% |
|TERMINAL (d) | 5/22 (23%) 1/21 (5%) 4/22 (18%) 17/24 (71%) 24/24 (100%) |
|FIRST INCIDENCE | 533 563 588 505 314 |
|-------------------| |
|STATISTICAL TESTS | |
|-------------------| |
|LIFE TABLE | P<0.001 ** P=0.055N P=0.519 P<0.001 ** P<0.001 ** |
|POLY 3 | P<0.001 ** P=0.047N* P=0.523 P<0.001 ** P<0.001 ** |
|POLY 1.5 | P<0.001 ** P=0.048N* P=0.507 P<0.001 ** P<0.001 ** |
|POLY 6 | P<0.001 ** P=0.045N* P=0.542 P<0.001 ** P<0.001 ** |
|LOGISTIC REGRESSION| P<0.001 ** P=0.050N P=0.517 P<0.001 ** P<0.001 ** |
|COCH-ARM / FISHERS | P<0.001 ** P=0.046N* P=0.483 P<0.001 ** P<0.001 ** |
|ORDER RESTRICTED | P<0.001 ** (e) (e) (e) (e) |
|=================================================================================================================================|
| | |
| | Females |
|Dose | 0 NG / 10 NG / 100 NG / 300 NG / 1000 NG/ |
| | 0 UG 10 UG 100 UG 300 UG 1000 UG |
|=================================================================================================================================|
| |
|Liver: Centrilobular |
| Degeneration |
| |
| |
|---------------------------------------------------------------------------------------------------------------------------------|
|LESION RATES | |
|----------- | |
|OVERALL (a) | 5/53 (9%) 7/53 (13%) 2/52 (4%) 4/52 (8%) 3/51 (6%) |
|POLY-3 RATE (b) | 5/39.53 7/40.74 2/39.46 4/38.67 3/38.89 |
|POLY-3 PERCENT (g) | 12.7% 17.2% 5.1% 10.3% 7.7% |
|TERMINAL (d) | 1/22 (5%) 1/21 (5%) 0/22 (0%) 1/24 (4%) 0/24 (0%) |
|FIRST INCIDENCE | 449 407 531 552 181 |
|-------------------| |
|STATISTICAL TESTS | |
|-------------------| |
|LIFE TABLE | P=0.271N P=0.380 P=0.217N P=0.501N P=0.370N |
|POLY 3 | P=0.262N P=0.399 P=0.214N P=0.514N P=0.364N |
|POLY 1.5 | P=0.267N P=0.384 P=0.218N P=0.516N P=0.372N |
|POLY 6 | P=0.260N P=0.420 P=0.214N P=0.507N P=0.359N |
|LOGISTIC REGRESSION| P=0.246N P=0.388 P=0.223N P=0.513N P=0.325N |
|COCH-ARM / FISHERS | P=0.271N P=0.380 P=0.226N P=0.512N P=0.380N |
|ORDER RESTRICTED | P=0.253N (e) (e) (e) (e) |
|=================================================================================================================================|
Date: 03/03/04 EXPERIMENT: 96020 TEST: 01 Page 26
Statistical Analysis of Non-neoplastic Lesions in Rats(SPRAGUE-DAWLEY) - TEF EVALUATION (BINARY MIXTURE; PCB 126
Terminal Sacrifice at 105 weeks
|=================================================================================================================================|
| | |
| | Females |
|Dose | 0 NG / 10 NG / 100 NG / 300 NG / 1000 NG/ |
| | 0 UG 10 UG 100 UG 300 UG 1000 UG |
|=================================================================================================================================|
| |
|Liver: Hepatocyte |
| Hypertrophy |
| |
| |
|---------------------------------------------------------------------------------------------------------------------------------|
|LESION RATES | |
|----------- | |
|OVERALL (a) | 1/53 (2%) 7/53 (13%) 17/52 (33%) 33/52 (63%) 50/51 (98%) |
|POLY-3 RATE (b) | 1/38.74 7/39.50 17/44.38 33/47.28 50/50.00 |
|POLY-3 PERCENT (g) | 2.6% 17.7% 38.3% 69.8% 100.0% |
|TERMINAL (d) | 0/22 (0%) 2/21 (10%) 6/22 (27%) 14/24 (58%) 24/24 (100%) |
|FIRST INCIDENCE | 556 378 125 254 169 |
|-------------------| |
|STATISTICAL TESTS | |
|-------------------| |
|LIFE TABLE | P<0.001 ** P=0.035 * P<0.001 ** P<0.001 ** P<0.001 ** |
|POLY 3 | P<0.001 ** P=0.030 * P<0.001 ** P<0.001 ** P<0.001 ** |
|POLY 1.5 | P<0.001 ** P=0.029 * P<0.001 ** P<0.001 ** P<0.001 ** |
|POLY 6 | P<0.001 ** P=0.033 * P<0.001 ** P<0.001 ** P<0.001 ** |
|LOGISTIC REGRESSION| P<0.001 ** P=0.033 * P<0.001 ** P<0.001 ** P<0.001 ** |
|COCH-ARM / FISHERS | P<0.001 ** P=0.030 * P<0.001 ** P<0.001 ** P<0.001 ** |
|ORDER RESTRICTED | P<0.001 ** (e) (e) (e) (e) |
|=================================================================================================================================|
| | |
| | Females |
|Dose | 0 NG / 10 NG / 100 NG / 300 NG / 1000 NG/ |
| | 0 UG 10 UG 100 UG 300 UG 1000 UG |
|=================================================================================================================================|
| |
|Liver: Hepatocyte |
| Multinucleated |
| |
| |
|---------------------------------------------------------------------------------------------------------------------------------|
|LESION RATES | |
|----------- | |
|OVERALL (a) | 0/53 (0%) 0/53 (0%) 14/52 (27%) 46/52 (88%) 48/51 (94%) |
|POLY-3 RATE (b) | 0/38.18 0/37.40 14/40.64 46/47.78 48/50.00 |
|POLY-3 PERCENT (g) | 0.0% 0.0% 34.5% 96.3% 96.0% |
|TERMINAL (d) | 0/22 (0%) 0/21 (0%) 9/22 (41%) 23/24 (96%) 22/24 (92%) |
|FIRST INCIDENCE | --- --- 531 310 169 |
|-------------------| |
|STATISTICAL TESTS | |
|-------------------| |
|LIFE TABLE | P<0.001 ** (e) P<0.001 ** P<0.001 ** P<0.001 ** |
|POLY 3 | P<0.001 ** (e) P<0.001 ** P<0.001 ** P<0.001 ** |
|POLY 1.5 | P<0.001 ** (e) P<0.001 ** P<0.001 ** P<0.001 ** |
|POLY 6 | P<0.001 ** (e) P<0.001 ** P<0.001 ** P<0.001 ** |
|LOGISTIC REGRESSION| P<0.001 ** (e) P<0.001 ** P<0.001 ** P<0.001 ** |
|COCH-ARM / FISHERS | P<0.001 ** (e) P<0.001 ** P<0.001 ** P<0.001 ** |
|ORDER RESTRICTED | P<0.001 ** (e) (e) (e) (e) |
|=================================================================================================================================|
Date: 03/03/04 EXPERIMENT: 96020 TEST: 01 Page 27
Statistical Analysis of Non-neoplastic Lesions in Rats(SPRAGUE-DAWLEY) - TEF EVALUATION (BINARY MIXTURE; PCB 126
Terminal Sacrifice at 105 weeks
|=================================================================================================================================|
| | |
| | Females |
|Dose | 0 NG / 10 NG / 100 NG / 300 NG / 1000 NG/ |
| | 0 UG 10 UG 100 UG 300 UG 1000 UG |
|=================================================================================================================================|
| |
|Liver: Oval Cell |
| Hyperplasia |
| |
| |
|---------------------------------------------------------------------------------------------------------------------------------|
|LESION RATES | |
|----------- | |
|OVERALL (a) | 2/53 (4%) 2/53 (4%) 15/52 (29%) 39/52 (75%) 46/51 (90%) |
|POLY-3 RATE (b) | 2/38.18 2/37.40 15/40.18 39/43.48 46/46.37 |
|POLY-3 PERCENT (g) | 5.2% 5.4% 37.3% 89.7% 99.2% |
|TERMINAL (d) | 2/22 (9%) 2/21 (10%) 8/22 (36%) 22/24 (92%) 24/24 (100%) |
|FIRST INCIDENCE | 729 (T) 729 (T) 603 499 314 |
|-------------------| |
|STATISTICAL TESTS | |
|-------------------| |
|LIFE TABLE | P<0.001 ** P=0.681 P<0.001 ** P<0.001 ** P<0.001 ** |
|POLY 3 | P<0.001 ** P=0.688 P<0.001 ** P<0.001 ** P<0.001 ** |
|POLY 1.5 | P<0.001 ** P=0.687 P<0.001 ** P<0.001 ** P<0.001 ** |
|POLY 6 | P<0.001 ** P=0.691 P<0.001 ** P<0.001 ** P<0.001 ** |
|LOGISTIC REGRESSION| P<0.001 ** P=0.681 P<0.001 ** P<0.001 ** P<0.001 ** |
|COCH-ARM / FISHERS | P<0.001 ** P=0.691N P<0.001 ** P<0.001 ** P<0.001 ** |
|ORDER RESTRICTED | P<0.001 ** (e) (e) (e) (e) |
|=================================================================================================================================|
| | |
| | Females |
|Dose | 0 NG / 10 NG / 100 NG / 300 NG / 1000 NG/ |
| | 0 UG 10 UG 100 UG 300 UG 1000 UG |
|=================================================================================================================================|
| |
|Liver: Portal |
| Fibrosis |
| |
| |
|---------------------------------------------------------------------------------------------------------------------------------|
|LESION RATES | |
|----------- | |
|OVERALL (a) | 0/53 (0%) 0/53 (0%) 0/52 (0%) 7/52 (13%) 34/51 (67%) |
|POLY-3 RATE (b) | 0/38.18 0/37.40 0/38.82 7/37.83 34/41.62 |
|POLY-3 PERCENT (g) | 0.0% 0.0% 0.0% 18.5% 81.7% |
|TERMINAL (d) | 0/22 (0%) 0/21 (0%) 0/22 (0%) 6/24 (25%) 19/24 (79%) |
|FIRST INCIDENCE | --- --- --- 603 540 |
|-------------------| |
|STATISTICAL TESTS | |
|-------------------| |
|LIFE TABLE | P<0.001 ** (e) (e) P=0.011 * P<0.001 ** |
|POLY 3 | P<0.001 ** (e) (e) P=0.007 ** P<0.001 ** |
|POLY 1.5 | P<0.001 ** (e) (e) P=0.007 ** P<0.001 ** |
|POLY 6 | P<0.001 ** (e) (e) P=0.007 ** P<0.001 ** |
|LOGISTIC REGRESSION| P<0.001 ** (e) (e) P=0.008 ** P<0.001 ** |
|COCH-ARM / FISHERS | P<0.001 ** (e) (e) P=0.006 ** P<0.001 ** |
|ORDER RESTRICTED | P<0.001 ** (e) (e) (e) (e) |
|=================================================================================================================================|
Date: 03/03/04 EXPERIMENT: 96020 TEST: 01 Page 28
Statistical Analysis of Non-neoplastic Lesions in Rats(SPRAGUE-DAWLEY) - TEF EVALUATION (BINARY MIXTURE; PCB 126
Terminal Sacrifice at 105 weeks
|=================================================================================================================================|
| | |
| | Females |
|Dose | 0 NG / 10 NG / 100 NG / 300 NG / 1000 NG/ |
| | 0 UG 10 UG 100 UG 300 UG 1000 UG |
|=================================================================================================================================|
| |
|Lung |
| Infiltration Cellular Histiocyte |
| |
| |
|---------------------------------------------------------------------------------------------------------------------------------|
|LESION RATES | |
|----------- | |
|OVERALL (a) | 47/53 (89%) 41/53 (77%) 47/52 (90%) 46/53 (87%) 45/52 (87%) |
|POLY-3 RATE (b) | 47/48.79 41/47.13 47/48.37 46/46.97 45/46.54 |
|POLY-3 PERCENT (g) | 96.3% 87.0% 97.2% 97.9% 96.7% |
|TERMINAL (d) | 22/22 (100%) 17/21 (81%) 22/22 (100%) 24/24 (100%) 24/24 (100%) |
|FIRST INCIDENCE | 345 167 461 254 314 |
|-------------------| |
|STATISTICAL TESTS | |
|-------------------| |
|LIFE TABLE | P=0.466N P=0.306N P=0.524N P=0.413N P=0.392N |
|POLY 3 | P=0.201 P=0.068N P=0.669 P=0.583 P=0.714 |
|POLY 1.5 | P=0.156 P=0.071N P=0.561 P=0.593 P=0.585 |
|POLY 6 | P=0.290 P=0.069N P=0.821 P=0.697 P=0.726N |
|LOGISTIC REGRESSION| P=0.177 P=0.120N P=0.629 P=0.584 P=0.478 |
|COCH-ARM / FISHERS | P=0.445 P=0.098N P=0.514 P=0.500N P=0.485N |
|ORDER RESTRICTED | P=0.103 (e) (e) (e) (e) |
|=================================================================================================================================|
| | |
| | Females |
|Dose | 0 NG / 10 NG / 100 NG / 300 NG / 1000 NG/ |
| | 0 UG 10 UG 100 UG 300 UG 1000 UG |
|=================================================================================================================================|
| |
|Lung |
| Inflammation |
| |
| |
|---------------------------------------------------------------------------------------------------------------------------------|
|LESION RATES | |
|----------- | |
|OVERALL (a) | 8/53 (15%) 5/53 (9%) 2/52 (4%) 4/53 (8%) 1/52 (2%) |
|POLY-3 RATE (b) | 8/40.26 5/38.99 2/39.57 4/38.58 1/36.33 |
|POLY-3 PERCENT (g) | 19.9% 12.8% 5.1% 10.4% 2.8% |
|TERMINAL (d) | 4/22 (18%) 3/21 (14%) 1/22 (5%) 2/24 (8%) 0/24 (0%) |
|FIRST INCIDENCE | 85 178 461 330 714 |
|-------------------| |
|STATISTICAL TESTS | |
|-------------------| |
|LIFE TABLE | P=0.038N* P=0.304N P=0.052N P=0.181N P=0.020N* |
|POLY 3 | P=0.047N* P=0.292N P=0.045N* P=0.193N P=0.022N* |
|POLY 1.5 | P=0.047N* P=0.292N P=0.047N* P=0.194N P=0.022N* |
|POLY 6 | P=0.046N* P=0.293N P=0.045N* P=0.191N P=0.022N* |
|LOGISTIC REGRESSION| P=0.038N* P=0.267N P=0.054N P=0.175N P=0.020N* |
|COCH-ARM / FISHERS | P=0.041N* P=0.278N P=0.049N* P=0.179N P=0.017N* |
|ORDER RESTRICTED | P=0.010N* (e) (e) (e) (e) |
|=================================================================================================================================|
Date: 03/03/04 EXPERIMENT: 96020 TEST: 01 Page 29
Statistical Analysis of Non-neoplastic Lesions in Rats(SPRAGUE-DAWLEY) - TEF EVALUATION (BINARY MIXTURE; PCB 126
Terminal Sacrifice at 105 weeks
|=================================================================================================================================|
| | |
| | Females |
|Dose | 0 NG / 10 NG / 100 NG / 300 NG / 1000 NG/ |
| | 0 UG 10 UG 100 UG 300 UG 1000 UG |
|=================================================================================================================================|
| |
|Lung |
| Metaplasia |
| |
| |
|---------------------------------------------------------------------------------------------------------------------------------|
|LESION RATES | |
|----------- | |
|OVERALL (a) | 0/53 (0%) 0/53 (0%) 1/52 (2%) 2/53 (4%) 11/52 (21%) |
|POLY-3 RATE (b) | 0/38.18 0/37.40 1/38.82 2/37.40 11/38.97 |
|POLY-3 PERCENT (g) | 0.0% 0.0% 2.6% 5.4% 28.2% |
|TERMINAL (d) | 0/22 (0%) 0/21 (0%) 1/22 (5%) 2/24 (8%) 5/24 (21%) |
|FIRST INCIDENCE | --- --- 729 (T) 729 (T) 477 |
|-------------------| |
|STATISTICAL TESTS | |
|-------------------| |
|LIFE TABLE | P<0.001 ** (e) P=0.500 P=0.257 P<0.001 ** |
|POLY 3 | P<0.001 ** (e) P=0.503 P=0.232 P<0.001 ** |
|POLY 1.5 | P<0.001 ** (e) P=0.501 P=0.232 P<0.001 ** |
|POLY 6 | P<0.001 ** (e) P=0.506 P=0.233 P<0.001 ** |
|LOGISTIC REGRESSION| P<0.001 ** (e) P=0.500 P=0.257 P<0.001 ** |
|COCH-ARM / FISHERS | P<0.001 ** (e) P=0.495 P=0.248 P<0.001 ** |
|ORDER RESTRICTED | P<0.001 ** (e) (e) (e) (e) |
|=================================================================================================================================|
| | |
| | Females |
|Dose | 0 NG / 10 NG / 100 NG / 300 NG / 1000 NG/ |
| | 0 UG 10 UG 100 UG 300 UG 1000 UG |
|=================================================================================================================================|
| |
|Lung: Alveolar Epithelium |
| Hyperplasia |
| |
| |
|---------------------------------------------------------------------------------------------------------------------------------|
|LESION RATES | |
|----------- | |
|OVERALL (a) | 23/53 (43%) 20/53 (38%) 17/52 (33%) 5/53 (9%) 5/52 (10%) |
|POLY-3 RATE (b) | 23/41.69 20/39.33 17/41.13 5/38.38 5/36.54 |
|POLY-3 PERCENT (g) | 55.2% 50.9% 41.3% 13.0% 13.7% |
|TERMINAL (d) | 15/22 (68%) 13/21 (62%) 10/22 (46%) 2/24 (8%) 4/24 (17%) |
|FIRST INCIDENCE | 345 534 461 505 654 |
|-------------------| |
|STATISTICAL TESTS | |
|-------------------| |
|LIFE TABLE | P<0.001N** P=0.399N P=0.156N P<0.001N** P<0.001N** |
|POLY 3 | P<0.001N** P=0.431N P=0.139N P<0.001N** P<0.001N** |
|POLY 1.5 | P<0.001N** P=0.412N P=0.153N P<0.001N** P<0.001N** |
|POLY 6 | P<0.001N** P=0.439N P=0.127N P<0.001N** P<0.001N** |
|LOGISTIC REGRESSION| P<0.001N** P=0.365N P=0.135N P<0.001N** P<0.001N** |
|COCH-ARM / FISHERS | P<0.001N** P=0.346N P=0.177N P<0.001N** P<0.001N** |
|ORDER RESTRICTED | P<0.001N** (e) (e) (e) (e) |
|=================================================================================================================================|
Date: 03/03/04 EXPERIMENT: 96020 TEST: 01 Page 30
Statistical Analysis of Non-neoplastic Lesions in Rats(SPRAGUE-DAWLEY) - TEF EVALUATION (BINARY MIXTURE; PCB 126
Terminal Sacrifice at 105 weeks
|=================================================================================================================================|
| | |
| | Females |
|Dose | 0 NG / 10 NG / 100 NG / 300 NG / 1000 NG/ |
| | 0 UG 10 UG 100 UG 300 UG 1000 UG |
|=================================================================================================================================|
| |
|Lung: Alveolar Epithelium |
| Metaplasia Bronchiolar |
| |
| |
|---------------------------------------------------------------------------------------------------------------------------------|
|LESION RATES | |
|----------- | |
|OVERALL (a) | 0/53 (0%) 6/53 (11%) 23/52 (44%) 34/53 (64%) 32/52 (62%) |
|POLY-3 RATE (b) | 0/38.18 6/37.53 23/43.10 34/41.55 32/41.06 |
|POLY-3 PERCENT (g) | 0.0% 16.0% 53.4% 81.8% 77.9% |
|TERMINAL (d) | 0/22 (0%) 4/21 (19%) 11/22 (50%) 23/24 (96%) 21/24 (88%) |
|FIRST INCIDENCE | --- 698 491 505 477 |
|-------------------| |
|STATISTICAL TESTS | |
|-------------------| |
|LIFE TABLE | P<0.001 ** P=0.016 * P<0.001 ** P<0.001 ** P<0.001 ** |
|POLY 3 | P<0.001 ** P=0.013 * P<0.001 ** P<0.001 ** P<0.001 ** |
|POLY 1.5 | P<0.001 ** P=0.014 * P<0.001 ** P<0.001 ** P<0.001 ** |
|POLY 6 | P<0.001 ** P=0.013 * P<0.001 ** P<0.001 ** P<0.001 ** |
|LOGISTIC REGRESSION| P<0.001 ** P=0.015 * P<0.001 ** P<0.001 ** P<0.001 ** |
|COCH-ARM / FISHERS | P<0.001 ** P=0.013 * P<0.001 ** P<0.001 ** P<0.001 ** |
|ORDER RESTRICTED | P<0.001 ** (e) (e) (e) (e) |
|=================================================================================================================================|
| | |
| | Females |
|Dose | 0 NG / 10 NG / 100 NG / 300 NG / 1000 NG/ |
| | 0 UG 10 UG 100 UG 300 UG 1000 UG |
|=================================================================================================================================|
| |
|Lymph Node, Mandibular |
| Ectasia |
| |
| |
|---------------------------------------------------------------------------------------------------------------------------------|
|LESION RATES | |
|----------- | |
|OVERALL (a) | 0/53 (0%) 3/51 (6%) 6/52 (12%) 3/50 (6%) 6/51 (12%) |
|POLY-3 RATE (b) | 0/38.18 3/37.12 6/39.91 3/35.88 6/36.73 |
|POLY-3 PERCENT (g) | 0.0% 8.1% 15.0% 8.4% 16.3% |
|TERMINAL (d) | 0/22 (0%) 2/21 (10%) 2/22 (9%) 2/24 (8%) 4/23 (17%) |
|FIRST INCIDENCE | --- 589 469 603 314 |
|-------------------| |
|STATISTICAL TESTS | |
|-------------------| |
|LIFE TABLE | P=0.091 P=0.118 P=0.023 * P=0.131 P=0.020 * |
|POLY 3 | P=0.072 P=0.112 P=0.017 * P=0.106 P=0.012 * |
|POLY 1.5 | P=0.070 P=0.111 P=0.016 * P=0.105 P=0.012 * |
|POLY 6 | P=0.075 P=0.115 P=0.018 * P=0.111 P=0.013 * |
|LOGISTIC REGRESSION| P=0.068 P=0.113 P=0.018 * P=0.108 P=0.015 * |
|COCH-ARM / FISHERS | P=0.079 P=0.114 P=0.013 * P=0.111 P=0.012 * |
|ORDER RESTRICTED | P=0.011 * (e) (e) (e) (e) |
|=================================================================================================================================|
Date: 03/03/04 EXPERIMENT: 96020 TEST: 01 Page 31
Statistical Analysis of Non-neoplastic Lesions in Rats(SPRAGUE-DAWLEY) - TEF EVALUATION (BINARY MIXTURE; PCB 126
Terminal Sacrifice at 105 weeks
|=================================================================================================================================|
| | |
| | Females |
|Dose | 0 NG / 10 NG / 100 NG / 300 NG / 1000 NG/ |
| | 0 UG 10 UG 100 UG 300 UG 1000 UG |
|=================================================================================================================================|
| |
|Lymph Node, Mandibular |
| Hyperplasia |
| |
| |
|---------------------------------------------------------------------------------------------------------------------------------|
|LESION RATES | |
|----------- | |
|OVERALL (a) | 37/53 (70%) 37/51 (73%) 40/52 (77%) 36/50 (72%) 31/51 (61%) |
|POLY-3 RATE (b) | 37/46.61 37/44.00 40/48.42 36/42.27 31/41.45 |
|POLY-3 PERCENT (g) | 79.4% 84.1% 82.6% 85.2% 74.8% |
|TERMINAL (d) | 18/22 (82%) 19/21 (91%) 19/22 (86%) 23/24 (96%) 18/23 (78%) |
|FIRST INCIDENCE | 418 337 125 363 169 |
|-------------------| |
|STATISTICAL TESTS | |
|-------------------| |
|LIFE TABLE | P=0.092N P=0.493 P=0.416 P=0.399N P=0.210N |
|POLY 3 | P=0.194N P=0.369 P=0.441 P=0.317 P=0.391N |
|POLY 1.5 | P=0.154N P=0.386 P=0.381 P=0.346 P=0.348N |
|POLY 6 | P=0.245N P=0.385 P=0.519 P=0.312 P=0.428N |
|LOGISTIC REGRESSION| P=0.123N P=0.425 P=0.295 P=0.403 P=0.300N |
|COCH-ARM / FISHERS | P=0.073N P=0.464 P=0.273 P=0.489 P=0.223N |
|ORDER RESTRICTED | P=0.260N (e) (e) (e) (e) |
|=================================================================================================================================|
| | |
| | Females |
|Dose | 0 NG / 10 NG / 100 NG / 300 NG / 1000 NG/ |
| | 0 UG 10 UG 100 UG 300 UG 1000 UG |
|=================================================================================================================================|
| |
|Lymph Node, Mandibular |
| Hyperplasia Lymphoid |
| |
| |
|---------------------------------------------------------------------------------------------------------------------------------|
|LESION RATES | |
|----------- | |
|OVERALL (a) | 1/53 (2%) 2/51 (4%) 3/52 (6%) 2/50 (4%) 5/51 (10%) |
|POLY-3 RATE (b) | 1/38.18 2/37.38 3/40.46 2/36.99 5/36.79 |
|POLY-3 PERCENT (g) | 2.6% 5.4% 7.4% 5.4% 13.6% |
|TERMINAL (d) | 1/22 (5%) 1/21 (5%) 1/22 (5%) 0/24 (0%) 3/23 (13%) |
|FIRST INCIDENCE | 729 (T) 469 254 363 169 |
|-------------------| |
|STATISTICAL TESTS | |
|-------------------| |
|LIFE TABLE | P=0.080 P=0.492 P=0.310 P=0.508 P=0.112 |
|POLY 3 | P=0.064 P=0.493 P=0.325 P=0.489 P=0.090 |
|POLY 1.5 | P=0.064 P=0.488 P=0.316 P=0.481 P=0.088 |
|POLY 6 | P=0.065 P=0.500 P=0.334 P=0.502 P=0.094 |
|LOGISTIC REGRESSION| P=0.092 P=0.485 P=0.282 P=0.508 P=0.096 |
|COCH-ARM / FISHERS | P=0.070 P=0.485 P=0.302 P=0.478 P=0.094 |
|ORDER RESTRICTED | P=0.044 * (e) (e) (e) (e) |
|=================================================================================================================================|
Date: 03/03/04 EXPERIMENT: 96020 TEST: 01 Page 32
Statistical Analysis of Non-neoplastic Lesions in Rats(SPRAGUE-DAWLEY) - TEF EVALUATION (BINARY MIXTURE; PCB 126
Terminal Sacrifice at 105 weeks
|=================================================================================================================================|
| | |
| | Females |
|Dose | 0 NG / 10 NG / 100 NG / 300 NG / 1000 NG/ |
| | 0 UG 10 UG 100 UG 300 UG 1000 UG |
|=================================================================================================================================|
| |
|Lymph Node, Mesenteric |
| Hyperplasia |
| |
| |
|---------------------------------------------------------------------------------------------------------------------------------|
|LESION RATES | |
|----------- | |
|OVERALL (a) | 0/53 (0%) 0/53 (0%) 0/52 (0%) 1/52 (2%) 2/49 (4%) |
|POLY-3 RATE (b) | 0/38.18 0/37.40 0/38.82 1/38.06 2/35.41 |
|POLY-3 PERCENT (g) | 0.0% 0.0% 0.0% 2.6% 5.7% |
|TERMINAL (d) | 0/22 (0%) 0/21 (0%) 0/22 (0%) 0/24 (0%) 2/24 (8%) |
|FIRST INCIDENCE | --- --- --- 506 729 (T) |
|-------------------| |
|STATISTICAL TESTS | |
|-------------------| |
|LIFE TABLE | P=0.049 * (e) (e) P=0.500 P=0.257 |
|POLY 3 | P=0.036 * (e) (e) P=0.499 P=0.220 |
|POLY 1.5 | P=0.035 * (e) (e) P=0.497 P=0.216 |
|POLY 6 | P=0.037 * (e) (e) P=0.503 P=0.224 |
|LOGISTIC REGRESSION| P=0.036 * (e) (e) P=0.501 P=0.257 |
|COCH-ARM / FISHERS | P=0.037 * (e) (e) P=0.495 P=0.228 |
|ORDER RESTRICTED | P=0.040 * (e) (e) (e) (e) |
|=================================================================================================================================|
| | |
| | Females |
|Dose | 0 NG / 10 NG / 100 NG / 300 NG / 1000 NG/ |
| | 0 UG 10 UG 100 UG 300 UG 1000 UG |
|=================================================================================================================================|
| |
|Lymph Node: Lumbar |
| Ectasia |
| |
| |
|---------------------------------------------------------------------------------------------------------------------------------|
|LESION RATES | |
|----------- | |
|OVERALL (a) | 4/4 (100%) 4/7 (57%) 0/2 (0%) 1/7 (14%) 0/14 (0%) |
|POLY-3 RATE (b) | 4/4.00 4/4.24 0/0.91 1/4.32 0/10.53 |
|POLY-3 PERCENT (g) | 100.0% 94.4% 0.0% 23.2% 0.0% |
|TERMINAL (d) | 1/1 (100%) 3/3 (100%) 0/0 (0%) 0/2 (0%) 0/9 (0%) |
|FIRST INCIDENCE | 449 469 --- 552 --- |
|-------------------| |
|STATISTICAL TESTS | |
|-------------------| |
|LIFE TABLE | P=0.002N** P=0.322N P=0.118N P=0.150N P=0.022N* |
|POLY 3 | P<0.001N** P=1.000N P=0.047N* P=0.009N** P<0.001N** |
|POLY 1.5 | P<0.001N** P=0.719N P<0.001N** P=0.002N** P<0.001N** |
|POLY 6 | P<0.001N** P=1.000N P=0.638N P=0.043N* P<0.001N** |
|LOGISTIC REGRESSION| P<0.001N** (e) P=0.064N P=0.017N* P<0.001N** |
|COCH-ARM / FISHERS | P<0.001N** P=0.212N P=0.067N P=0.015N* P<0.001N** |
|ORDER RESTRICTED | P<0.001N** (e) (e) (e) (e) |
|=================================================================================================================================|
Date: 03/03/04 EXPERIMENT: 96020 TEST: 01 Page 33
Statistical Analysis of Non-neoplastic Lesions in Rats(SPRAGUE-DAWLEY) - TEF EVALUATION (BINARY MIXTURE; PCB 126
Terminal Sacrifice at 105 weeks
|=================================================================================================================================|
| | |
| | Females |
|Dose | 0 NG / 10 NG / 100 NG / 300 NG / 1000 NG/ |
| | 0 UG 10 UG 100 UG 300 UG 1000 UG |
|=================================================================================================================================|
| |
|Lymph Node: Lumbar |
| Hemorrhage |
| |
| |
|---------------------------------------------------------------------------------------------------------------------------------|
|LESION RATES | |
|----------- | |
|OVERALL (a) | 0/4 (0%) 2/7 (29%) 0/2 (0%) 0/7 (0%) 0/14 (0%) |
|POLY-3 RATE (b) | 0/2.13 2/4.24 0/0.91 0/3.75 0/10.53 |
|POLY-3 PERCENT (g) | 0.0% 47.2% 0.0% 0.0% 0.0% |
|TERMINAL (d) | 0/1 (0%) 1/3 (33%) 0/0 (0%) 0/2 (0%) 0/9 (0%) |
|FIRST INCIDENCE | --- 469 --- --- --- |
|-------------------| |
|STATISTICAL TESTS | |
|-------------------| |
|LIFE TABLE | P=0.169N P=0.353 (e) (e) (e) |
|POLY 3 | P=0.083N P=0.381 (e) (e) (e) |
|POLY 1.5 | P=0.129N P=0.341 (e) (e) (e) |
|POLY 6 | P=0.040N* P=0.461 (e) (e) (e) |
|LOGISTIC REGRESSION| P=0.147N P=0.332 (e) (e) (e) |
|COCH-ARM / FISHERS | P=0.166N P=0.382 (e) (e) (e) |
|ORDER RESTRICTED | P=0.212N (e) (e) (e) (e) |
|=================================================================================================================================|
| | |
| | Females |
|Dose | 0 NG / 10 NG / 100 NG / 300 NG / 1000 NG/ |
| | 0 UG 10 UG 100 UG 300 UG 1000 UG |
|=================================================================================================================================|
| |
|Lymph Node: Lumbar |
| Hyperplasia |
| |
| |
|---------------------------------------------------------------------------------------------------------------------------------|
|LESION RATES | |
|----------- | |
|OVERALL (a) | 4/4 (100%) 2/7 (29%) 0/2 (0%) 0/7 (0%) 0/14 (0%) |
|POLY-3 RATE (b) | 4/4.00 2/3.51 0/0.91 0/3.75 0/10.53 |
|POLY-3 PERCENT (g) | 100.0% 57.1% 0.0% 0.0% 0.0% |
|TERMINAL (d) | 1/1 (100%) 2/3 (67%) 0/0 (0%) 0/2 (0%) 0/9 (0%) |
|FIRST INCIDENCE | 449 729 (T) --- --- --- |
|-------------------| |
|STATISTICAL TESTS | |
|-------------------| |
|LIFE TABLE | P=0.007N** P=0.105N P=0.118N P=0.048N* P=0.022N* |
|POLY 3 | P<0.001N** P=0.259N P=0.047N* P<0.001N** P<0.001N** |
|POLY 1.5 | P<0.001N** P=0.102N P<0.001N** P<0.001N** P<0.001N** |
|POLY 6 | P<0.001N** P=0.404N P=0.638N P<0.001N** P<0.001N** |
|LOGISTIC REGRESSION| P=0.002N** P=0.054N P=0.064N P=0.004N** P<0.001N** |
|COCH-ARM / FISHERS | P=0.006N** P=0.045N* P=0.067N P=0.003N** P<0.001N** |
|ORDER RESTRICTED | P<0.001N** (e) (e) (e) (e) |
|=================================================================================================================================|
Date: 03/03/04 EXPERIMENT: 96020 TEST: 01 Page 34
Statistical Analysis of Non-neoplastic Lesions in Rats(SPRAGUE-DAWLEY) - TEF EVALUATION (BINARY MIXTURE; PCB 126
Terminal Sacrifice at 105 weeks
|=================================================================================================================================|
| | |
| | Females |
|Dose | 0 NG / 10 NG / 100 NG / 300 NG / 1000 NG/ |
| | 0 UG 10 UG 100 UG 300 UG 1000 UG |
|=================================================================================================================================|
| |
|Lymph Node: Mediastinal |
| Ectasia |
| |
| |
|---------------------------------------------------------------------------------------------------------------------------------|
|LESION RATES | |
|----------- | |
|OVERALL (a) | 0/4 (0%) 0/7 (0%) 0/2 (0%) 0/7 (0%) 3/14 (21%) |
|POLY-3 RATE (b) | 0/2.13 0/3.51 0/0.91 0/3.75 3/12.45 |
|POLY-3 PERCENT (g) | 0.0% 0.0% 0.0% 0.0% 24.1% |
|TERMINAL (d) | 0/1 (0%) 0/3 (0%) 0/0 (0%) 0/2 (0%) 0/9 (0%) |
|FIRST INCIDENCE | --- --- --- --- 314 |
|-------------------| |
|STATISTICAL TESTS | |
|-------------------| |
|LIFE TABLE | P=0.003 ** (e) (e) (e) P=0.129 |
|POLY 3 | P=0.139 (e) (e) (e) P=0.536 |
|POLY 1.5 | P=0.093 (e) (e) (e) P=0.477 |
|POLY 6 | P=0.193 (e) (e) (e) P=0.593 |
|LOGISTIC REGRESSION| P=0.035 * (e) (e) (e) P=0.377 |
|COCH-ARM / FISHERS | P=0.051 (e) (e) (e) P=0.446 |
|ORDER RESTRICTED | P=0.417 (e) (e) (e) (e) |
|=================================================================================================================================|
| | |
| | Females |
|Dose | 0 NG / 10 NG / 100 NG / 300 NG / 1000 NG/ |
| | 0 UG 10 UG 100 UG 300 UG 1000 UG |
|=================================================================================================================================|
| |
|Lymph Node: Mediastinal |
| Hemorrhage |
| |
| |
|---------------------------------------------------------------------------------------------------------------------------------|
|LESION RATES | |
|----------- | |
|OVERALL (a) | 0/4 (0%) 0/7 (0%) 0/2 (0%) 1/7 (14%) 2/14 (14%) |
|POLY-3 RATE (b) | 0/2.13 0/3.51 0/0.91 1/4.66 2/11.80 |
|POLY-3 PERCENT (g) | 0.0% 0.0% 0.0% 21.5% 16.9% |
|TERMINAL (d) | 0/1 (0%) 0/3 (0%) 0/0 (0%) 0/2 (0%) 0/9 (0%) |
|FIRST INCIDENCE | --- --- --- 330 477 |
|-------------------| |
|STATISTICAL TESTS | |
|-------------------| |
|LIFE TABLE | P=0.041 * (e) (e) P=0.488 P=0.232 |
|POLY 3 | P=0.459 (e) (e) P=0.653 P=0.631 |
|POLY 1.5 | P=0.369 (e) (e) P=0.635 P=0.588 |
|POLY 6 | P=0.539 (e) (e) P=0.673 P=0.673 |
|LOGISTIC REGRESSION| P=0.192 (e) (e) (e) P=0.526 |
|COCH-ARM / FISHERS | P=0.247 (e) (e) P=0.636 P=0.595 |
|ORDER RESTRICTED | P=0.522 (e) (e) (e) (e) |
|=================================================================================================================================|
Date: 03/03/04 EXPERIMENT: 96020 TEST: 01 Page 35
Statistical Analysis of Non-neoplastic Lesions in Rats(SPRAGUE-DAWLEY) - TEF EVALUATION (BINARY MIXTURE; PCB 126
Terminal Sacrifice at 105 weeks
|=================================================================================================================================|
| | |
| | Females |
|Dose | 0 NG / 10 NG / 100 NG / 300 NG / 1000 NG/ |
| | 0 UG 10 UG 100 UG 300 UG 1000 UG |
|=================================================================================================================================|
| |
|Lymph Node: Mediastinal |
| Hyperplasia |
| |
| |
|---------------------------------------------------------------------------------------------------------------------------------|
|LESION RATES | |
|----------- | |
|OVERALL (a) | 0/4 (0%) 1/7 (14%) 0/2 (0%) 1/7 (14%) 5/14 (36%) |
|POLY-3 RATE (b) | 0/2.13 1/4.41 0/0.91 1/4.42 5/12.36 |
|POLY-3 PERCENT (g) | 0.0% 22.7% 0.0% 22.6% 40.5% |
|TERMINAL (d) | 0/1 (0%) 0/3 (0%) 0/0 (0%) 0/2 (0%) 2/9 (22%) |
|FIRST INCIDENCE | --- 337 --- 506 76 |
|-------------------| |
|STATISTICAL TESTS | |
|-------------------| |
|LIFE TABLE | P=0.014 * P=0.492 (e) P=0.500 P=0.105 |
|POLY 3 | P=0.195 P=0.643 (e) P=0.645 P=0.380 |
|POLY 1.5 | P=0.129 P=0.617 (e) P=0.627 P=0.305 |
|POLY 6 | P=0.281 P=0.681 (e) P=0.669 P=0.465 |
|LOGISTIC REGRESSION| P=0.039 * P=0.805 (e) P=0.625 P=0.197 |
|COCH-ARM / FISHERS | P=0.065 P=0.636 (e) P=0.636 P=0.234 |
|ORDER RESTRICTED | P=0.340 (e) (e) (e) (e) |
|=================================================================================================================================|
| | |
| | Females |
|Dose | 0 NG / 10 NG / 100 NG / 300 NG / 1000 NG/ |
| | 0 UG 10 UG 100 UG 300 UG 1000 UG |
|=================================================================================================================================|
| |
|Lymph Node: Pancreatic |
| Hyperplasia |
| |
| |
|---------------------------------------------------------------------------------------------------------------------------------|
|LESION RATES | |
|----------- | |
|OVERALL (a) | 0/4 (0%) 0/7 (0%) 0/2 (0%) 1/7 (14%) 3/14 (21%) |
|POLY-3 RATE (b) | 0/2.13 0/3.51 0/0.91 1/3.75 3/10.53 |
|POLY-3 PERCENT (g) | 0.0% 0.0% 0.0% 26.6% 28.5% |
|TERMINAL (d) | 0/1 (0%) 0/3 (0%) 0/0 (0%) 1/2 (50%) 3/9 (33%) |
|FIRST INCIDENCE | --- --- --- 729 (T) 729 (T) |
|-------------------| |
|STATISTICAL TESTS | |
|-------------------| |
|LIFE TABLE | P=0.315 (e) (e) P=0.638 P=0.669 |
|POLY 3 | P=0.225 (e) (e) P=0.619 P=0.497 |
|POLY 1.5 | P=0.171 (e) (e) P=0.613 P=0.445 |
|POLY 6 | P=0.278 (e) (e) P=0.626 P=0.555 |
|LOGISTIC REGRESSION| (e) (e) (e) P=0.638 P=0.669 |
|COCH-ARM / FISHERS | P=0.111 (e) (e) P=0.636 P=0.446 |
|ORDER RESTRICTED | P=0.399 (e) (e) (e) (e) |
|=================================================================================================================================|
Date: 03/03/04 EXPERIMENT: 96020 TEST: 01 Page 36
Statistical Analysis of Non-neoplastic Lesions in Rats(SPRAGUE-DAWLEY) - TEF EVALUATION (BINARY MIXTURE; PCB 126
Terminal Sacrifice at 105 weeks
|=================================================================================================================================|
| | |
| | Females |
|Dose | 0 NG / 10 NG / 100 NG / 300 NG / 1000 NG/ |
| | 0 UG 10 UG 100 UG 300 UG 1000 UG |
|=================================================================================================================================|
| |
|Lymph Node: Renal |
| Hyperplasia |
| |
| |
|---------------------------------------------------------------------------------------------------------------------------------|
|LESION RATES | |
|----------- | |
|OVERALL (a) | 0/4 (0%) 1/7 (14%) 0/2 (0%) 2/7 (29%) 2/14 (14%) |
|POLY-3 RATE (b) | 0/2.13 1/3.51 0/0.91 2/4.81 2/10.53 |
|POLY-3 PERCENT (g) | 0.0% 28.5% 0.0% 41.6% 19.0% |
|TERMINAL (d) | 0/1 (0%) 1/3 (33%) 0/0 (0%) 0/2 (0%) 2/9 (22%) |
|FIRST INCIDENCE | --- 729 (T) --- 506 729 (T) |
|-------------------| |
|STATISTICAL TESTS | |
|-------------------| |
|LIFE TABLE | P=0.591 P=0.718 (e) P=0.227 P=0.773 |
|POLY 3 | P=0.562N P=0.605 (e) P=0.422 P=0.613 |
|POLY 1.5 | P=0.643N P=0.590 (e) P=0.386 P=0.575 |
|POLY 6 | P=0.474N P=0.643 (e) P=0.478 P=0.655 |
|LOGISTIC REGRESSION| P=0.595N P=0.718 (e) P=0.356 P=0.773 |
|COCH-ARM / FISHERS | P=0.564 P=0.636 (e) P=0.382 P=0.595 |
|ORDER RESTRICTED | P=0.466 (e) (e) (e) (e) |
|=================================================================================================================================|
| | |
| | Females |
|Dose | 0 NG / 10 NG / 100 NG / 300 NG / 1000 NG/ |
| | 0 UG 10 UG 100 UG 300 UG 1000 UG |
|=================================================================================================================================|
| |
|Mammary Gland |
| Cyst |
| |
| |
|---------------------------------------------------------------------------------------------------------------------------------|
|LESION RATES | |
|----------- | |
|OVERALL (a) | 3/53 (6%) 2/53 (4%) 2/52 (4%) 3/53 (6%) 1/52 (2%) |
|POLY-3 RATE (b) | 3/39.88 2/38.20 2/39.26 3/38.06 1/36.59 |
|POLY-3 PERCENT (g) | 7.5% 5.2% 5.1% 7.9% 2.7% |
|TERMINAL (d) | 1/22 (5%) 0/21 (0%) 1/22 (5%) 2/24 (8%) 0/24 (0%) |
|FIRST INCIDENCE | 345 589 603 506 640 |
|-------------------| |
|STATISTICAL TESTS | |
|-------------------| |
|LIFE TABLE | P=0.310N P=0.522N P=0.499N P=0.650N P=0.329N |
|POLY 3 | P=0.331N P=0.520N P=0.507N P=0.642 P=0.336N |
|POLY 1.5 | P=0.330N P=0.518N P=0.509N P=0.644 P=0.335N |
|POLY 6 | P=0.329N P=0.515N P=0.505N P=0.646 P=0.332N |
|LOGISTIC REGRESSION| P=0.300N P=0.477N P=0.525N P=0.649N P=0.272N |
|COCH-ARM / FISHERS | P=0.308N P=0.500N P=0.509N P=0.661N P=0.316N |
|ORDER RESTRICTED | P=0.322N (e) (e) (e) (e) |
|=================================================================================================================================|
Date: 03/03/04 EXPERIMENT: 96020 TEST: 01 Page 37
Statistical Analysis of Non-neoplastic Lesions in Rats(SPRAGUE-DAWLEY) - TEF EVALUATION (BINARY MIXTURE; PCB 126
Terminal Sacrifice at 105 weeks
|=================================================================================================================================|
| | |
| | Females |
|Dose | 0 NG / 10 NG / 100 NG / 300 NG / 1000 NG/ |
| | 0 UG 10 UG 100 UG 300 UG 1000 UG |
|=================================================================================================================================|
| |
|Mammary Gland |
| Hyperplasia |
| |
| |
|---------------------------------------------------------------------------------------------------------------------------------|
|LESION RATES | |
|----------- | |
|OVERALL (a) | 29/53 (55%) 29/53 (55%) 25/52 (48%) 22/53 (42%) 3/52 (6%) |
|POLY-3 RATE (b) | 29/44.60 29/41.84 25/41.84 22/41.66 3/36.97 |
|POLY-3 PERCENT (g) | 65.0% 69.3% 59.8% 52.8% 8.1% |
|TERMINAL (d) | 16/22 (73%) 16/21 (76%) 15/22 (68%) 11/24 (46%) 1/24 (4%) |
|FIRST INCIDENCE | 418 469 469 499 606 |
|-------------------| |
|STATISTICAL TESTS | |
|-------------------| |
|LIFE TABLE | P<0.001N** P=0.504 P=0.272N P=0.117N P<0.001N** |
|POLY 3 | P<0.001N** P=0.418 P=0.382N P=0.164N P<0.001N** |
|POLY 1.5 | P<0.001N** P=0.458 P=0.348N P=0.157N P<0.001N** |
|POLY 6 | P<0.001N** P=0.418 P=0.428N P=0.154N P<0.001N** |
|LOGISTIC REGRESSION| P<0.001N** P=0.532 P=0.259N P=0.134N P<0.001N** |
|COCH-ARM / FISHERS | P<0.001N** P=0.577N P=0.314N P=0.122N P<0.001N** |
|ORDER RESTRICTED | P<0.001N** (e) (e) (e) (e) |
|=================================================================================================================================|
| | |
| | Females |
|Dose | 0 NG / 10 NG / 100 NG / 300 NG / 1000 NG/ |
| | 0 UG 10 UG 100 UG 300 UG 1000 UG |
|=================================================================================================================================|
| |
|Mammary Gland |
| Inflammation Granulomatous |
| |
| |
|---------------------------------------------------------------------------------------------------------------------------------|
|LESION RATES | |
|----------- | |
|OVERALL (a) | 5/53 (9%) 0/53 (0%) 4/52 (8%) 3/53 (6%) 0/52 (0%) |
|POLY-3 RATE (b) | 5/39.94 0/37.40 4/39.50 3/37.73 0/36.27 |
|POLY-3 PERCENT (g) | 12.5% 0.0% 10.1% 8.0% 0.0% |
|TERMINAL (d) | 2/22 (9%) 0/21 (0%) 2/22 (9%) 1/24 (4%) 0/24 (0%) |
|FIRST INCIDENCE | 345 --- 603 650 --- |
|-------------------| |
|STATISTICAL TESTS | |
|-------------------| |
|LIFE TABLE | P=0.085N P=0.042N* P=0.496N P=0.345N P=0.034N* |
|POLY 3 | P=0.090N P=0.035N* P=0.507N P=0.387N P=0.038N* |
|POLY 1.5 | P=0.092N P=0.035N* P=0.510N P=0.382N P=0.038N* |
|POLY 6 | P=0.088N P=0.035N* P=0.501N P=0.384N P=0.038N* |
|LOGISTIC REGRESSION| P=0.091N P=0.031N* P=0.513N P=0.359N P=0.032N* |
|COCH-ARM / FISHERS | P=0.088N P=0.028N* P=0.512N P=0.358N P=0.030N* |
|ORDER RESTRICTED | P=0.016N* (e) (e) (e) (e) |
|=================================================================================================================================|
Date: 03/03/04 EXPERIMENT: 96020 TEST: 01 Page 38
Statistical Analysis of Non-neoplastic Lesions in Rats(SPRAGUE-DAWLEY) - TEF EVALUATION (BINARY MIXTURE; PCB 126
Terminal Sacrifice at 105 weeks
|=================================================================================================================================|
| | |
| | Females |
|Dose | 0 NG / 10 NG / 100 NG / 300 NG / 1000 NG/ |
| | 0 UG 10 UG 100 UG 300 UG 1000 UG |
|=================================================================================================================================|
| |
|Mesentery: Artery |
| Inflammation Chronic |
| |
| |
|---------------------------------------------------------------------------------------------------------------------------------|
|LESION RATES | |
|----------- | |
|OVERALL (a) | 1/47 (2%) 1/47 (2%) 1/46 (2%) 2/47 (4%) 4/42 (10%) |
|POLY-3 RATE (b) | 1/34.51 1/32.95 1/34.30 2/33.24 4/32.89 |
|POLY-3 PERCENT (g) | 2.9% 3.0% 2.9% 6.0% 12.2% |
|TERMINAL (d) | 0/19 (0%) 1/18 (6%) 0/20 (0%) 2/21 (10%) 2/22 (9%) |
|FIRST INCIDENCE | 688 729 (T) 531 729 (T) 563 |
|-------------------| |
|STATISTICAL TESTS | |
|-------------------| |
|LIFE TABLE | P=0.062 P=0.758N P=0.749N P=0.528 P=0.197 |
|POLY 3 | P=0.040 * P=0.751 P=0.760 P=0.487 P=0.161 |
|POLY 1.5 | P=0.037 * P=0.751 P=0.756 P=0.487 P=0.150 |
|POLY 6 | P=0.045 * P=0.754 P=0.759N P=0.491 P=0.176 |
|LOGISTIC REGRESSION| P=0.039 * P=0.758 P=0.763 P=0.503 P=0.150 |
|COCH-ARM / FISHERS | P=0.034 * P=0.753N P=0.747 P=0.500 P=0.147 |
|ORDER RESTRICTED | P=0.067 (e) (e) (e) (e) |
|=================================================================================================================================|
| | |
| | Females |
|Dose | 0 NG / 10 NG / 100 NG / 300 NG / 1000 NG/ |
| | 0 UG 10 UG 100 UG 300 UG 1000 UG |
|=================================================================================================================================|
| |
|Mesentery: Fat |
| Necrosis |
| |
| |
|---------------------------------------------------------------------------------------------------------------------------------|
|LESION RATES | |
|----------- | |
|OVERALL (a) | 0/47 (0%) 2/47 (4%) 2/46 (4%) 1/47 (2%) 0/42 (0%) |
|POLY-3 RATE (b) | 0/34.35 2/33.28 2/33.74 1/33.92 0/32.03 |
|POLY-3 PERCENT (g) | 0.0% 6.0% 5.9% 3.0% 0.0% |
|TERMINAL (d) | 0/19 (0%) 1/18 (6%) 1/20 (5%) 0/21 (0%) 0/22 (0%) |
|FIRST INCIDENCE | --- 636 715 499 --- |
|-------------------| |
|STATISTICAL TESTS | |
|-------------------| |
|LIFE TABLE | P=0.252N P=0.231 P=0.259 P=0.509 (e) |
|POLY 3 | P=0.269N P=0.229 P=0.232 P=0.497 (e) |
|POLY 1.5 | P=0.278N P=0.228 P=0.230 P=0.495 (e) |
|POLY 6 | P=0.258N P=0.233 P=0.235 P=0.503 (e) |
|LOGISTIC REGRESSION| P=0.275N P=0.229 P=0.241 P=0.564 (e) |
|COCH-ARM / FISHERS | P=0.282N P=0.247 P=0.242 P=0.500 (e) |
|ORDER RESTRICTED | P=0.299N (e) (e) (e) (e) |
|=================================================================================================================================|
Date: 03/03/04 EXPERIMENT: 96020 TEST: 01 Page 39
Statistical Analysis of Non-neoplastic Lesions in Rats(SPRAGUE-DAWLEY) - TEF EVALUATION (BINARY MIXTURE; PCB 126
Terminal Sacrifice at 105 weeks
|=================================================================================================================================|
| | |
| | Females |
|Dose | 0 NG / 10 NG / 100 NG / 300 NG / 1000 NG/ |
| | 0 UG 10 UG 100 UG 300 UG 1000 UG |
|=================================================================================================================================|
| |
|Nose |
| Inflammation |
| |
| |
|---------------------------------------------------------------------------------------------------------------------------------|
|LESION RATES | |
|----------- | |
|OVERALL (a) | 22/53 (42%) 13/53 (25%) 13/53 (25%) 13/53 (25%) 31/53 (58%) |
|POLY-3 RATE (b) | 22/43.64 13/40.23 13/42.58 13/40.22 31/43.98 |
|POLY-3 PERCENT (g) | 50.4% 32.3% 30.5% 32.3% 70.5% |
|TERMINAL (d) | 10/22 (46%) 7/21 (33%) 4/22 (18%) 5/24 (21%) 17/24 (71%) |
|FIRST INCIDENCE | 418 178 407 539 71 |
|-------------------| |
|STATISTICAL TESTS | |
|-------------------| |
|LIFE TABLE | P<0.001 ** P=0.085N P=0.069N P=0.067N P=0.106 |
|POLY 3 | P<0.001 ** P=0.066N P=0.043N* P=0.067N P=0.036 * |
|POLY 1.5 | P<0.001 ** P=0.057N P=0.043N* P=0.062N P=0.034 * |
|POLY 6 | P<0.001 ** P=0.076N P=0.043N* P=0.069N P=0.044 * |
|LOGISTIC REGRESSION| P<0.001 ** P=0.052N P=0.047N* P=0.053N P=0.041 * |
|COCH-ARM / FISHERS | P<0.001 ** P=0.049N* P=0.049N* P=0.049N* P=0.060 |
|ORDER RESTRICTED | P<0.001 ** (e) (e) (e) (e) |
|=================================================================================================================================|
| | |
| | Females |
|Dose | 0 NG / 10 NG / 100 NG / 300 NG / 1000 NG/ |
| | 0 UG 10 UG 100 UG 300 UG 1000 UG |
|=================================================================================================================================|
| |
|Nose: Glands |
| Hyperplasia |
| |
| |
|---------------------------------------------------------------------------------------------------------------------------------|
|LESION RATES | |
|----------- | |
|OVERALL (a) | 0/53 (0%) 0/53 (0%) 0/53 (0%) 0/53 (0%) 8/53 (15%) |
|POLY-3 RATE (b) | 0/38.18 0/37.40 0/39.03 0/37.40 8/37.65 |
|POLY-3 PERCENT (g) | 0.0% 0.0% 0.0% 0.0% 21.3% |
|TERMINAL (d) | 0/22 (0%) 0/21 (0%) 0/22 (0%) 0/24 (0%) 5/24 (21%) |
|FIRST INCIDENCE | --- --- --- --- 595 |
|-------------------| |
|STATISTICAL TESTS | |
|-------------------| |
|LIFE TABLE | P<0.001 ** (e) (e) (e) P=0.006 ** |
|POLY 3 | P<0.001 ** (e) (e) (e) P=0.003 ** |
|POLY 1.5 | P<0.001 ** (e) (e) (e) P=0.003 ** |
|POLY 6 | P<0.001 ** (e) (e) (e) P=0.003 ** |
|LOGISTIC REGRESSION| P<0.001 ** (e) (e) (e) P=0.004 ** |
|COCH-ARM / FISHERS | P<0.001 ** (e) (e) (e) P=0.003 ** |
|ORDER RESTRICTED | P<0.001 ** (e) (e) (e) (e) |
|=================================================================================================================================|
Date: 03/03/04 EXPERIMENT: 96020 TEST: 01 Page 40
Statistical Analysis of Non-neoplastic Lesions in Rats(SPRAGUE-DAWLEY) - TEF EVALUATION (BINARY MIXTURE; PCB 126
Terminal Sacrifice at 105 weeks
|=================================================================================================================================|
| | |
| | Females |
|Dose | 0 NG / 10 NG / 100 NG / 300 NG / 1000 NG/ |
| | 0 UG 10 UG 100 UG 300 UG 1000 UG |
|=================================================================================================================================|
| |
|Nose: Olfactory Epithelium |
| Degeneration |
| |
| |
|---------------------------------------------------------------------------------------------------------------------------------|
|LESION RATES | |
|----------- | |
|OVERALL (a) | 1/53 (2%) 0/53 (0%) 0/53 (0%) 0/53 (0%) 2/53 (4%) |
|POLY-3 RATE (b) | 1/38.18 0/37.40 0/39.03 0/37.40 2/37.98 |
|POLY-3 PERCENT (g) | 2.6% 0.0% 0.0% 0.0% 5.3% |
|TERMINAL (d) | 1/22 (5%) 0/21 (0%) 0/22 (0%) 0/24 (0%) 0/24 (0%) |
|FIRST INCIDENCE | 729 (T) --- --- --- 71 |
|-------------------| |
|STATISTICAL TESTS | |
|-------------------| |
|LIFE TABLE | P=0.110 P=0.509N P=0.500N P=0.483N P=0.507 |
|POLY 3 | P=0.105 P=0.504N P=0.496N P=0.504N P=0.498 |
|POLY 1.5 | P=0.105 P=0.504N P=0.497N P=0.505N P=0.494 |
|POLY 6 | P=0.106 P=0.503N P=0.494N P=0.502N P=0.506 |
|LOGISTIC REGRESSION| P=0.152 (e) (e) (e) P=0.587 |
|COCH-ARM / FISHERS | P=0.106 P=0.500N P=0.500N P=0.500N P=0.500 |
|ORDER RESTRICTED | P=0.081 (e) (e) (e) (e) |
|=================================================================================================================================|
| | |
| | Females |
|Dose | 0 NG / 10 NG / 100 NG / 300 NG / 1000 NG/ |
| | 0 UG 10 UG 100 UG 300 UG 1000 UG |
|=================================================================================================================================|
| |
|Nose: Olfactory Epithelium |
| Metaplasia |
| |
| |
|---------------------------------------------------------------------------------------------------------------------------------|
|LESION RATES | |
|----------- | |
|OVERALL (a) | 4/53 (8%) 3/53 (6%) 5/53 (9%) 6/53 (11%) 15/53 (28%) |
|POLY-3 RATE (b) | 4/38.51 3/37.55 5/39.70 6/38.67 15/37.97 |
|POLY-3 PERCENT (g) | 10.4% 8.0% 12.6% 15.5% 39.5% |
|TERMINAL (d) | 2/22 (9%) 2/21 (10%) 2/22 (9%) 1/24 (4%) 11/24 (46%) |
|FIRST INCIDENCE | 664 689 636 603 595 |
|-------------------| |
|STATISTICAL TESTS | |
|-------------------| |
|LIFE TABLE | P<0.001 ** P=0.517N P=0.510 P=0.388 P=0.007 ** |
|POLY 3 | P<0.001 ** P=0.514N P=0.519 P=0.370 P=0.002 ** |
|POLY 1.5 | P<0.001 ** P=0.513N P=0.511 P=0.361 P=0.002 ** |
|POLY 6 | P<0.001 ** P=0.513N P=0.529 P=0.389 P=0.003 ** |
|LOGISTIC REGRESSION| P<0.001 ** P=0.507N P=0.517 P=0.357 P=0.003 ** |
|COCH-ARM / FISHERS | P<0.001 ** P=0.500N P=0.500 P=0.371 P=0.005 ** |
|ORDER RESTRICTED | P<0.001 ** (e) (e) (e) (e) |
|=================================================================================================================================|
Date: 03/03/04 EXPERIMENT: 96020 TEST: 01 Page 41
Statistical Analysis of Non-neoplastic Lesions in Rats(SPRAGUE-DAWLEY) - TEF EVALUATION (BINARY MIXTURE; PCB 126
Terminal Sacrifice at 105 weeks
|=================================================================================================================================|
| | |
| | Females |
|Dose | 0 NG / 10 NG / 100 NG / 300 NG / 1000 NG/ |
| | 0 UG 10 UG 100 UG 300 UG 1000 UG |
|=================================================================================================================================|
| |
|Nose: Respiratory Epithelium |
| Hyperplasia |
| |
| |
|---------------------------------------------------------------------------------------------------------------------------------|
|LESION RATES | |
|----------- | |
|OVERALL (a) | 10/53 (19%) 5/53 (9%) 7/53 (13%) 11/53 (21%) 20/53 (38%) |
|POLY-3 RATE (b) | 10/39.82 5/37.87 7/40.47 11/40.12 20/41.12 |
|POLY-3 PERCENT (g) | 25.1% 13.2% 17.3% 27.4% 48.6% |
|TERMINAL (d) | 6/22 (27%) 4/21 (19%) 2/22 (9%) 3/24 (13%) 11/24 (46%) |
|FIRST INCIDENCE | 418 589 581 539 477 |
|-------------------| |
|STATISTICAL TESTS | |
|-------------------| |
|LIFE TABLE | P<0.001 ** P=0.154N P=0.293N P=0.529 P=0.039 * |
|POLY 3 | P<0.001 ** P=0.146N P=0.278N P=0.508 P=0.020 * |
|POLY 1.5 | P<0.001 ** P=0.144N P=0.287N P=0.489 P=0.017 * |
|POLY 6 | P<0.001 ** P=0.146N P=0.264N P=0.549 P=0.029 * |
|LOGISTIC REGRESSION| P<0.001 ** P=0.137N P=0.284N P=0.481 P=0.018 * |
|COCH-ARM / FISHERS | P<0.001 ** P=0.132N P=0.299N P=0.500 P=0.026 * |
|ORDER RESTRICTED | P<0.001 ** (e) (e) (e) (e) |
|=================================================================================================================================|
| | |
| | Females |
|Dose | 0 NG / 10 NG / 100 NG / 300 NG / 1000 NG/ |
| | 0 UG 10 UG 100 UG 300 UG 1000 UG |
|=================================================================================================================================|
| |
|Oral Mucosa: Gingival |
| Hyperplasia |
| |
| |
|---------------------------------------------------------------------------------------------------------------------------------|
|LESION RATES | |
|----------- | |
|OVERALL (a) | 8/12 (67%) 8/11 (73%) 18/25 (72%) 22/30 (73%) 24/36 (67%) |
|POLY-3 RATE (b) | 8/11.04 8/10.69 18/23.89 22/27.81 24/32.83 |
|POLY-3 PERCENT (g) | 72.5% 74.9% 75.3% 79.1% 73.1% |
|TERMINAL (d) | 2/3 (67%) 2/4 (50%) 8/11 (73%) 12/15 (80%) 14/17 (82%) |
|FIRST INCIDENCE | 451 499 469 451 479 |
|-------------------| |
|STATISTICAL TESTS | |
|-------------------| |
|LIFE TABLE | P=0.110 P=0.552N P=0.232 P=0.188 P=0.172 |
|POLY 3 | P=0.489N P=0.642 P=0.595 P=0.491 P=0.646 |
|POLY 1.5 | P=0.436N P=0.602 P=0.558 P=0.480 P=0.642 |
|POLY 6 | P=0.582N P=0.697 P=0.654 P=0.525 P=0.648 |
|LOGISTIC REGRESSION| P=0.389N P=0.535 P=0.510 P=0.491 P=0.635N |
|COCH-ARM / FISHERS | P=0.386N P=0.556 P=0.513 P=0.469 P=0.631 |
|ORDER RESTRICTED | P=0.706 (e) (e) (e) (e) |
|=================================================================================================================================|
Date: 03/03/04 EXPERIMENT: 96020 TEST: 01 Page 42
Statistical Analysis of Non-neoplastic Lesions in Rats(SPRAGUE-DAWLEY) - TEF EVALUATION (BINARY MIXTURE; PCB 126
Terminal Sacrifice at 105 weeks
|=================================================================================================================================|
| | |
| | Females |
|Dose | 0 NG / 10 NG / 100 NG / 300 NG / 1000 NG/ |
| | 0 UG 10 UG 100 UG 300 UG 1000 UG |
|=================================================================================================================================|
| |
|Ovary |
| Atrophy |
| |
| |
|---------------------------------------------------------------------------------------------------------------------------------|
|LESION RATES | |
|----------- | |
|OVERALL (a) | 45/53 (85%) 44/53 (83%) 45/52 (87%) 43/52 (83%) 16/49 (33%) |
|POLY-3 RATE (b) | 45/49.16 44/48.17 45/50.01 43/48.11 16/37.95 |
|POLY-3 PERCENT (g) | 91.5% 91.4% 90.0% 89.4% 42.2% |
|TERMINAL (d) | 21/22 (96%) 19/21 (91%) 20/22 (91%) 22/24 (92%) 9/24 (38%) |
|FIRST INCIDENCE | 345 330 254 254 485 |
|-------------------| |
|STATISTICAL TESTS | |
|-------------------| |
|LIFE TABLE | P<0.001N** P=0.539 P=0.526N P=0.363N P<0.001N** |
|POLY 3 | P<0.001N** P=0.644N P=0.535N P=0.493N P<0.001N** |
|POLY 1.5 | P<0.001N** P=0.637N P=0.611N P=0.480N P<0.001N** |
|POLY 6 | P<0.001N** P=0.583N P=0.438N P=0.514N P<0.001N** |
|LOGISTIC REGRESSION| P<0.001N** P=0.583N P=0.547 P=0.499N P<0.001N** |
|COCH-ARM / FISHERS | P<0.001N** P=0.500N P=0.516 P=0.483N P<0.001N** |
|ORDER RESTRICTED | P<0.001N** (e) (e) (e) (e) |
|=================================================================================================================================|
| | |
| | Females |
|Dose | 0 NG / 10 NG / 100 NG / 300 NG / 1000 NG/ |
| | 0 UG 10 UG 100 UG 300 UG 1000 UG |
|=================================================================================================================================|
| |
|Ovary |
| Cyst |
| |
| |
|---------------------------------------------------------------------------------------------------------------------------------|
|LESION RATES | |
|----------- | |
|OVERALL (a) | 14/53 (26%) 7/53 (13%) 17/52 (33%) 14/52 (27%) 13/49 (27%) |
|POLY-3 RATE (b) | 14/40.50 7/38.46 17/42.41 14/39.03 13/37.89 |
|POLY-3 PERCENT (g) | 34.6% 18.2% 40.1% 35.9% 34.3% |
|TERMINAL (d) | 8/22 (36%) 3/21 (14%) 6/22 (27%) 11/24 (46%) 7/24 (29%) |
|FIRST INCIDENCE | 451 580 469 330 477 |
|-------------------| |
|STATISTICAL TESTS | |
|-------------------| |
|LIFE TABLE | P=0.516 P=0.091N P=0.366 P=0.519N P=0.467N |
|POLY 3 | P=0.379 P=0.077N P=0.383 P=0.546 P=0.586N |
|POLY 1.5 | P=0.352 P=0.077N P=0.352 P=0.554 P=0.577 |
|POLY 6 | P=0.417 P=0.075N P=0.419 P=0.532 P=0.551N |
|LOGISTIC REGRESSION| P=0.344 P=0.074N P=0.335 P=0.563 P=0.579 |
|COCH-ARM / FISHERS | P=0.353 P=0.071N P=0.312 P=0.564 P=0.583 |
|ORDER RESTRICTED | P=0.278 (e) (e) (e) (e) |
|=================================================================================================================================|
Date: 03/03/04 EXPERIMENT: 96020 TEST: 01 Page 43
Statistical Analysis of Non-neoplastic Lesions in Rats(SPRAGUE-DAWLEY) - TEF EVALUATION (BINARY MIXTURE; PCB 126
Terminal Sacrifice at 105 weeks
|=================================================================================================================================|
| | |
| | Females |
|Dose | 0 NG / 10 NG / 100 NG / 300 NG / 1000 NG/ |
| | 0 UG 10 UG 100 UG 300 UG 1000 UG |
|=================================================================================================================================|
| |
|Oviduct |
| Cyst |
| |
| |
|---------------------------------------------------------------------------------------------------------------------------------|
|LESION RATES | |
|----------- | |
|OVERALL (a) | 1/1 (100%) 0/0 (0%) 1/1 (100%) 2/2 (100%) 0/3 (0%) |
|POLY-3 RATE (b) | 1/1.00 0/0.00 1/1.00 2/2.00 0/1.60 |
|POLY-3 PERCENT (g) | 100.0% 0.0% 100.0% 100.0% 0.0% |
|TERMINAL (d) | 1/1 (100%) 0/0 (0%) 0/0 (0%) 0/0 (0%) 0/1 (0%) |
|FIRST INCIDENCE | 729 (T) --- 603 539 --- |
|-------------------| |
|STATISTICAL TESTS | |
|-------------------| |
|LIFE TABLE | P=0.367N (e) (e) (e) P=0.500N |
|POLY 3 | (e) (e) (e) (e) P=0.207N |
|POLY 1.5 | (e) (e) (e) (e) P=0.008N** |
|POLY 6 | (e) (e) (e) (e) P=0.429N |
|LOGISTIC REGRESSION| P=0.030N* (e) (e) (e) (e) |
|COCH-ARM / FISHERS | P=0.026N* (e) (e) (e) P=0.250N |
|ORDER RESTRICTED | (e) (e) (e) (e) (e) |
|=================================================================================================================================|
| | |
| | Females |
|Dose | 0 NG / 10 NG / 100 NG / 300 NG / 1000 NG/ |
| | 0 UG 10 UG 100 UG 300 UG 1000 UG |
|=================================================================================================================================|
| |
|Oviduct |
| Inflammation Chronic |
| |
| |
|---------------------------------------------------------------------------------------------------------------------------------|
|LESION RATES | |
|----------- | |
|OVERALL (a) | 0/1 (0%) 0/0 (0%) 1/1 (100%) 0/2 (0%) 3/3 (100%) |
|POLY-3 RATE (b) | 0/1.00 0/0.00 1/1.00 0/1.14 3/3.00 |
|POLY-3 PERCENT (g) | 0.0% 0.0% 100.0% 0.0% 100.0% |
|TERMINAL (d) | 0/1 (0%) 0/0 (0%) 0/0 (0%) 0/0 (0%) 1/1 (100%) |
|FIRST INCIDENCE | --- --- 603 --- 485 |
|-------------------| |
|STATISTICAL TESTS | |
|-------------------| |
|LIFE TABLE | P=0.041 * (e) P=0.500 (e) P=0.127 |
|POLY 3 | (e) (e) P=1.000N (e) P=0.250 |
|POLY 1.5 | (e) (e) P=1.000N (e) P=0.250 |
|POLY 6 | (e) (e) P=1.000N (e) P=0.250 |
|LOGISTIC REGRESSION| P=0.173 (e) (e) (e) (e) |
|COCH-ARM / FISHERS | P=0.124 (e) P=0.500 (e) P=0.250 |
|ORDER RESTRICTED | (e) (e) (e) (e) (e) |
|=================================================================================================================================|
Date: 03/03/04 EXPERIMENT: 96020 TEST: 01 Page 44
Statistical Analysis of Non-neoplastic Lesions in Rats(SPRAGUE-DAWLEY) - TEF EVALUATION (BINARY MIXTURE; PCB 126
Terminal Sacrifice at 105 weeks
|=================================================================================================================================|
| | |
| | Females |
|Dose | 0 NG / 10 NG / 100 NG / 300 NG / 1000 NG/ |
| | 0 UG 10 UG 100 UG 300 UG 1000 UG |
|=================================================================================================================================|
| |
|Pancreas |
| Inflammation Chronic |
| |
| |
|---------------------------------------------------------------------------------------------------------------------------------|
|LESION RATES | |
|----------- | |
|OVERALL (a) | 0/53 (0%) 3/53 (6%) 3/52 (6%) 1/52 (2%) 4/50 (8%) |
|POLY-3 RATE (b) | 0/38.18 3/37.40 3/39.29 1/37.39 4/36.68 |
|POLY-3 PERCENT (g) | 0.0% 8.0% 7.6% 2.7% 10.9% |
|TERMINAL (d) | 0/22 (0%) 3/21 (14%) 2/22 (9%) 1/24 (4%) 2/24 (8%) |
|FIRST INCIDENCE | --- 729 (T) 589 729 (T) 563 |
|-------------------| |
|STATISTICAL TESTS | |
|-------------------| |
|LIFE TABLE | P=0.187 P=0.110 P=0.125 P=0.517 P=0.067 |
|POLY 3 | P=0.148 P=0.114 P=0.123 P=0.496 P=0.054 |
|POLY 1.5 | P=0.143 P=0.114 P=0.120 P=0.495 P=0.052 |
|POLY 6 | P=0.156 P=0.114 P=0.126 P=0.498 P=0.058 |
|LOGISTIC REGRESSION| P=0.144 P=0.110 P=0.122 P=0.517 P=0.054 |
|COCH-ARM / FISHERS | P=0.147 P=0.121 P=0.118 P=0.495 P=0.052 |
|ORDER RESTRICTED | P=0.030 * (e) (e) (e) (e) |
|=================================================================================================================================|
| | |
| | Females |
|Dose | 0 NG / 10 NG / 100 NG / 300 NG / 1000 NG/ |
| | 0 UG 10 UG 100 UG 300 UG 1000 UG |
|=================================================================================================================================|
| |
|Pancreas: Acinus |
| Atrophy |
| |
| |
|---------------------------------------------------------------------------------------------------------------------------------|
|LESION RATES | |
|----------- | |
|OVERALL (a) | 0/53 (0%) 2/53 (4%) 1/52 (2%) 1/52 (2%) 8/50 (16%) |
|POLY-3 RATE (b) | 0/38.18 2/37.40 1/39.29 1/37.39 8/38.53 |
|POLY-3 PERCENT (g) | 0.0% 5.4% 2.5% 2.7% 20.8% |
|TERMINAL (d) | 0/22 (0%) 2/21 (10%) 0/22 (0%) 1/24 (4%) 3/24 (13%) |
|FIRST INCIDENCE | --- 729 (T) 589 729 (T) 491 |
|-------------------| |
|STATISTICAL TESTS | |
|-------------------| |
|LIFE TABLE | P<0.001 ** P=0.227 P=0.511 P=0.517 P=0.007 ** |
|POLY 3 | P<0.001 ** P=0.232 P=0.506 P=0.496 P=0.003 ** |
|POLY 1.5 | P<0.001 ** P=0.232 P=0.502 P=0.495 P=0.003 ** |
|POLY 6 | P<0.001 ** P=0.233 P=0.510 P=0.498 P=0.004 ** |
|LOGISTIC REGRESSION| P<0.001 ** P=0.227 P=0.491 P=0.517 P=0.004 ** |
|COCH-ARM / FISHERS | P<0.001 ** P=0.248 P=0.495 P=0.495 P=0.002 ** |
|ORDER RESTRICTED | P<0.001 ** (e) (e) (e) (e) |
|=================================================================================================================================|
Date: 03/03/04 EXPERIMENT: 96020 TEST: 01 Page 45
Statistical Analysis of Non-neoplastic Lesions in Rats(SPRAGUE-DAWLEY) - TEF EVALUATION (BINARY MIXTURE; PCB 126
Terminal Sacrifice at 105 weeks
|=================================================================================================================================|
| | |
| | Females |
|Dose | 0 NG / 10 NG / 100 NG / 300 NG / 1000 NG/ |
| | 0 UG 10 UG 100 UG 300 UG 1000 UG |
|=================================================================================================================================|
| |
|Pancreas: Acinus |
| Hyperplasia |
| |
| |
|---------------------------------------------------------------------------------------------------------------------------------|
|LESION RATES | |
|----------- | |
|OVERALL (a) | 2/53 (4%) 0/53 (0%) 0/52 (0%) 1/52 (2%) 0/50 (0%) |
|POLY-3 RATE (b) | 2/38.18 0/37.40 0/38.82 1/37.39 0/35.82 |
|POLY-3 PERCENT (g) | 5.2% 0.0% 0.0% 2.7% 0.0% |
|TERMINAL (d) | 2/22 (9%) 0/21 (0%) 0/22 (0%) 1/24 (4%) 0/24 (0%) |
|FIRST INCIDENCE | 729 (T) --- --- 729 (T) --- |
|-------------------| |
|STATISTICAL TESTS | |
|-------------------| |
|LIFE TABLE | P=0.355N P=0.247N P=0.237N P=0.469N P=0.218N |
|POLY 3 | P=0.394N P=0.241N P=0.233N P=0.507N P=0.251N |
|POLY 1.5 | P=0.395N P=0.242N P=0.236N P=0.509N P=0.254N |
|POLY 6 | P=0.393N P=0.239N P=0.230N P=0.504N P=0.246N |
|LOGISTIC REGRESSION| P=0.355N (e) (e) P=0.469N (e) |
|COCH-ARM / FISHERS | P=0.393N P=0.248N P=0.252N P=0.507N P=0.262N |
|ORDER RESTRICTED | P=0.054N (e) (e) (e) (e) |
|=================================================================================================================================|
| | |
| | Females |
|Dose | 0 NG / 10 NG / 100 NG / 300 NG / 1000 NG/ |
| | 0 UG 10 UG 100 UG 300 UG 1000 UG |
|=================================================================================================================================|
| |
|Pancreas: Acinus |
| Vacuolization Cytoplasmic |
| |
| |
|---------------------------------------------------------------------------------------------------------------------------------|
|LESION RATES | |
|----------- | |
|OVERALL (a) | 0/53 (0%) 0/53 (0%) 0/52 (0%) 7/52 (13%) 40/50 (80%) |
|POLY-3 RATE (b) | 0/38.18 0/37.40 0/38.82 7/38.39 40/42.41 |
|POLY-3 PERCENT (g) | 0.0% 0.0% 0.0% 18.2% 94.3% |
|TERMINAL (d) | 0/22 (0%) 0/21 (0%) 0/22 (0%) 5/24 (21%) 24/24 (100%) |
|FIRST INCIDENCE | --- --- --- 552 314 |
|-------------------| |
|STATISTICAL TESTS | |
|-------------------| |
|LIFE TABLE | P<0.001 ** (e) (e) P=0.012 * P<0.001 ** |
|POLY 3 | P<0.001 ** (e) (e) P=0.007 ** P<0.001 ** |
|POLY 1.5 | P<0.001 ** (e) (e) P=0.007 ** P<0.001 ** |
|POLY 6 | P<0.001 ** (e) (e) P=0.008 ** P<0.001 ** |
|LOGISTIC REGRESSION| P<0.001 ** (e) (e) P=0.008 ** P<0.001 ** |
|COCH-ARM / FISHERS | P<0.001 ** (e) (e) P=0.006 ** P<0.001 ** |
|ORDER RESTRICTED | P<0.001 ** (e) (e) (e) (e) |
|=================================================================================================================================|
Date: 03/03/04 EXPERIMENT: 96020 TEST: 01 Page 46
Statistical Analysis of Non-neoplastic Lesions in Rats(SPRAGUE-DAWLEY) - TEF EVALUATION (BINARY MIXTURE; PCB 126
Terminal Sacrifice at 105 weeks
|=================================================================================================================================|
| | |
| | Females |
|Dose | 0 NG / 10 NG / 100 NG / 300 NG / 1000 NG/ |
| | 0 UG 10 UG 100 UG 300 UG 1000 UG |
|=================================================================================================================================|
| |
|Pancreas: Artery |
| Inflammation Chronic |
| |
| |
|---------------------------------------------------------------------------------------------------------------------------------|
|LESION RATES | |
|----------- | |
|OVERALL (a) | 0/53 (0%) 0/53 (0%) 1/52 (2%) 2/52 (4%) 2/50 (4%) |
|POLY-3 RATE (b) | 0/38.18 0/37.40 1/38.86 2/38.06 2/36.36 |
|POLY-3 PERCENT (g) | 0.0% 0.0% 2.6% 5.3% 5.5% |
|TERMINAL (d) | 0/22 (0%) 0/21 (0%) 0/22 (0%) 1/24 (4%) 1/24 (4%) |
|FIRST INCIDENCE | --- --- 720 506 563 |
|-------------------| |
|STATISTICAL TESTS | |
|-------------------| |
|LIFE TABLE | P=0.140 (e) P=0.517 P=0.249 P=0.252 |
|POLY 3 | P=0.119 (e) P=0.504 P=0.236 P=0.225 |
|POLY 1.5 | P=0.115 (e) P=0.501 P=0.234 P=0.222 |
|POLY 6 | P=0.124 (e) P=0.506 P=0.240 P=0.231 |
|LOGISTIC REGRESSION| P=0.114 (e) P=0.508 P=0.234 P=0.223 |
|COCH-ARM / FISHERS | P=0.116 (e) P=0.495 P=0.243 P=0.233 |
|ORDER RESTRICTED | P=0.112 (e) (e) (e) (e) |
|=================================================================================================================================|
| | |
| | Females |
|Dose | 0 NG / 10 NG / 100 NG / 300 NG / 1000 NG/ |
| | 0 UG 10 UG 100 UG 300 UG 1000 UG |
|=================================================================================================================================|
| |
|Pituitary Gland |
| Angiectasis |
| |
| |
|---------------------------------------------------------------------------------------------------------------------------------|
|LESION RATES | |
|----------- | |
|OVERALL (a) | 17/53 (32%) 20/53 (38%) 15/53 (28%) 17/52 (33%) 1/52 (2%) |
|POLY-3 RATE (b) | 17/40.84 20/40.36 15/40.14 17/39.38 1/36.27 |
|POLY-3 PERCENT (g) | 41.6% 49.6% 37.4% 43.2% 2.8% |
|TERMINAL (d) | 11/22 (50%) 9/21 (43%) 10/22 (46%) 9/24 (38%) 1/24 (4%) |
|FIRST INCIDENCE | 418 563 588 506 729 (T) |
|-------------------| |
|STATISTICAL TESTS | |
|-------------------| |
|LIFE TABLE | P<0.001N** P=0.318 P=0.400N P=0.519N P<0.001N** |
|POLY 3 | P<0.001N** P=0.305 P=0.433N P=0.535 P<0.001N** |
|POLY 1.5 | P<0.001N** P=0.298 P=0.426N P=0.521 P<0.001N** |
|POLY 6 | P<0.001N** P=0.352 P=0.439N P=0.581 P<0.001N** |
|LOGISTIC REGRESSION| P<0.001N** P=0.307 P=0.380N P=0.531 P<0.001N** |
|COCH-ARM / FISHERS | P<0.001N** P=0.342 P=0.416N P=0.556 P<0.001N** |
|ORDER RESTRICTED | P<0.001N** (e) (e) (e) (e) |
|=================================================================================================================================|
Date: 03/03/04 EXPERIMENT: 96020 TEST: 01 Page 47
Statistical Analysis of Non-neoplastic Lesions in Rats(SPRAGUE-DAWLEY) - TEF EVALUATION (BINARY MIXTURE; PCB 126
Terminal Sacrifice at 105 weeks
|=================================================================================================================================|
| | |
| | Females |
|Dose | 0 NG / 10 NG / 100 NG / 300 NG / 1000 NG/ |
| | 0 UG 10 UG 100 UG 300 UG 1000 UG |
|=================================================================================================================================|
| |
|Pituitary Gland |
| Cyst |
| |
| |
|---------------------------------------------------------------------------------------------------------------------------------|
|LESION RATES | |
|----------- | |
|OVERALL (a) | 1/53 (2%) 3/53 (6%) 0/53 (0%) 0/52 (0%) 0/52 (0%) |
|POLY-3 RATE (b) | 1/38.18 3/39.59 0/39.03 0/36.79 0/36.27 |
|POLY-3 PERCENT (g) | 2.6% 7.6% 0.0% 0.0% 0.0% |
|TERMINAL (d) | 1/22 (5%) 0/21 (0%) 0/22 (0%) 0/24 (0%) 0/24 (0%) |
|FIRST INCIDENCE | 729 (T) 178 --- --- --- |
|-------------------| |
|STATISTICAL TESTS | |
|-------------------| |
|LIFE TABLE | P=0.159N P=0.309 P=0.500N P=0.483N P=0.483N |
|POLY 3 | P=0.159N P=0.317 P=0.496N P=0.507N P=0.510N |
|POLY 1.5 | P=0.161N P=0.311 P=0.497N P=0.508N P=0.512N |
|POLY 6 | P=0.156N P=0.327 P=0.494N P=0.504N P=0.508N |
|LOGISTIC REGRESSION| P=0.130N P=0.335 (e) (e) (e) |
|COCH-ARM / FISHERS | P=0.160N P=0.309 P=0.500N P=0.505N P=0.505N |
|ORDER RESTRICTED | P=0.095N (e) (e) (e) (e) |
|=================================================================================================================================|
| | |
| | Females |
|Dose | 0 NG / 10 NG / 100 NG / 300 NG / 1000 NG/ |
| | 0 UG 10 UG 100 UG 300 UG 1000 UG |
|=================================================================================================================================|
| |
|Pituitary Gland |
| Cytoplasmic Alteration |
| |
| |
|---------------------------------------------------------------------------------------------------------------------------------|
|LESION RATES | |
|----------- | |
|OVERALL (a) | 0/53 (0%) 0/53 (0%) 3/53 (6%) 0/52 (0%) 0/52 (0%) |
|POLY-3 RATE (b) | 0/38.18 0/37.40 3/39.90 0/36.79 0/36.27 |
|POLY-3 PERCENT (g) | 0.0% 0.0% 7.5% 0.0% 0.0% |
|TERMINAL (d) | 0/22 (0%) 0/21 (0%) 0/22 (0%) 0/24 (0%) 0/24 (0%) |
|FIRST INCIDENCE | --- --- 589 --- --- |
|-------------------| |
|STATISTICAL TESTS | |
|-------------------| |
|LIFE TABLE | P=0.402N (e) P=0.135 (e) (e) |
|POLY 3 | P=0.379N (e) P=0.126 (e) (e) |
|POLY 1.5 | P=0.384N (e) P=0.123 (e) (e) |
|POLY 6 | P=0.372N (e) P=0.130 (e) (e) |
|LOGISTIC REGRESSION| P=0.390N (e) P=0.122 (e) (e) |
|COCH-ARM / FISHERS | P=0.385N (e) P=0.121 (e) (e) |
|ORDER RESTRICTED | P=0.307 (e) (e) (e) (e) |
|=================================================================================================================================|
Date: 03/03/04 EXPERIMENT: 96020 TEST: 01 Page 48
Statistical Analysis of Non-neoplastic Lesions in Rats(SPRAGUE-DAWLEY) - TEF EVALUATION (BINARY MIXTURE; PCB 126
Terminal Sacrifice at 105 weeks
|=================================================================================================================================|
| | |
| | Females |
|Dose | 0 NG / 10 NG / 100 NG / 300 NG / 1000 NG/ |
| | 0 UG 10 UG 100 UG 300 UG 1000 UG |
|=================================================================================================================================|
| |
|Pituitary Gland: Pars Distalis |
| Hyperplasia |
| |
| |
|---------------------------------------------------------------------------------------------------------------------------------|
|LESION RATES | |
|----------- | |
|OVERALL (a) | 13/53 (25%) 13/53 (25%) 19/53 (36%) 20/52 (38%) 13/52 (25%) |
|POLY-3 RATE (b) | 13/41.27 13/39.68 19/43.31 20/40.07 13/37.42 |
|POLY-3 PERCENT (g) | 31.5% 32.8% 43.9% 49.9% 34.7% |
|TERMINAL (d) | 6/22 (27%) 7/21 (33%) 10/22 (46%) 11/24 (46%) 9/24 (38%) |
|FIRST INCIDENCE | 451 534 469 505 606 |
|-------------------| |
|STATISTICAL TESTS | |
|-------------------| |
|LIFE TABLE | P=0.368N P=0.549 P=0.174 P=0.147 P=0.566N |
|POLY 3 | P=0.533 P=0.547 P=0.166 P=0.065 P=0.474 |
|POLY 1.5 | P=0.550N P=0.554 P=0.156 P=0.066 P=0.489 |
|POLY 6 | P=0.509 P=0.547 P=0.176 P=0.072 P=0.460 |
|LOGISTIC REGRESSION| P=0.491N P=0.570 P=0.150 P=0.077 P=0.531 |
|COCH-ARM / FISHERS | P=0.443N P=0.589N P=0.145 P=0.092 P=0.567 |
|ORDER RESTRICTED | P=0.243 (e) (e) (e) (e) |
|=================================================================================================================================|
| | |
| | Females |
|Dose | 0 NG / 10 NG / 100 NG / 300 NG / 1000 NG/ |
| | 0 UG 10 UG 100 UG 300 UG 1000 UG |
|=================================================================================================================================|
| |
|Pituitary Gland: Pars Intermedia |
| Hyperplasia |
| |
| |
|---------------------------------------------------------------------------------------------------------------------------------|
|LESION RATES | |
|----------- | |
|OVERALL (a) | 0/53 (0%) 0/53 (0%) 0/53 (0%) 0/52 (0%) 2/52 (4%) |
|POLY-3 RATE (b) | 0/38.18 0/37.40 0/39.03 0/36.79 2/37.68 |
|POLY-3 PERCENT (g) | 0.0% 0.0% 0.0% 0.0% 5.3% |
|TERMINAL (d) | 0/22 (0%) 0/21 (0%) 0/22 (0%) 0/24 (0%) 0/24 (0%) |
|FIRST INCIDENCE | --- --- --- --- 314 |
|-------------------| |
|STATISTICAL TESTS | |
|-------------------| |
|LIFE TABLE | P=0.017 * (e) (e) (e) P=0.225 |
|POLY 3 | P=0.018 * (e) (e) (e) P=0.233 |
|POLY 1.5 | P=0.018 * (e) (e) (e) P=0.229 |
|POLY 6 | P=0.019 * (e) (e) (e) P=0.239 |
|LOGISTIC REGRESSION| P=0.032 * (e) (e) (e) P=0.284 |
|COCH-ARM / FISHERS | P=0.019 * (e) (e) (e) P=0.243 |
|ORDER RESTRICTED | P=0.015 * (e) (e) (e) (e) |
|=================================================================================================================================|
Date: 03/03/04 EXPERIMENT: 96020 TEST: 01 Page 49
Statistical Analysis of Non-neoplastic Lesions in Rats(SPRAGUE-DAWLEY) - TEF EVALUATION (BINARY MIXTURE; PCB 126
Terminal Sacrifice at 105 weeks
|=================================================================================================================================|
| | |
| | Females |
|Dose | 0 NG / 10 NG / 100 NG / 300 NG / 1000 NG/ |
| | 0 UG 10 UG 100 UG 300 UG 1000 UG |
|=================================================================================================================================|
| |
|Skin |
| Ulcer |
| |
| |
|---------------------------------------------------------------------------------------------------------------------------------|
|LESION RATES | |
|----------- | |
|OVERALL (a) | 0/53 (0%) 0/53 (0%) 2/53 (4%) 0/53 (0%) 1/53 (2%) |
|POLY-3 RATE (b) | 0/38.18 0/37.40 2/39.13 0/37.40 1/36.53 |
|POLY-3 PERCENT (g) | 0.0% 0.0% 5.1% 0.0% 2.7% |
|TERMINAL (d) | 0/22 (0%) 0/21 (0%) 1/22 (5%) 0/24 (0%) 0/24 (0%) |
|FIRST INCIDENCE | --- --- 705 --- 714 |
|-------------------| |
|STATISTICAL TESTS | |
|-------------------| |
|LIFE TABLE | P=0.520 (e) P=0.252 (e) P=0.516 |
|POLY 3 | P=0.490 (e) P=0.242 (e) P=0.491 |
|POLY 1.5 | P=0.488 (e) P=0.240 (e) P=0.491 |
|POLY 6 | P=0.493 (e) P=0.244 (e) P=0.493 |
|LOGISTIC REGRESSION| P=0.491 (e) P=0.245 (e) P=0.495 |
|COCH-ARM / FISHERS | P=0.498 (e) P=0.248 (e) P=0.500 |
|ORDER RESTRICTED | P=0.297 (e) (e) (e) (e) |
|=================================================================================================================================|
| | |
| | Females |
|Dose | 0 NG / 10 NG / 100 NG / 300 NG / 1000 NG/ |
| | 0 UG 10 UG 100 UG 300 UG 1000 UG |
|=================================================================================================================================|
| |
|Spleen |
| Hematopoietic Cell Proliferation |
| |
| |
|---------------------------------------------------------------------------------------------------------------------------------|
|LESION RATES | |
|----------- | |
|OVERALL (a) | 51/53 (96%) 51/53 (96%) 49/52 (94%) 47/52 (90%) 44/50 (88%) |
|POLY-3 RATE (b) | 51/51.98 51/52.01 49/50.88 47/50.21 44/46.03 |
|POLY-3 PERCENT (g) | 98.1% 98.1% 96.3% 93.6% 95.6% |
|TERMINAL (d) | 22/22 (100%) 21/21 (100%) 22/22 (100%) 24/24 (100%) 24/24 (100%) |
|FIRST INCIDENCE | 85 167 125 142 169 |
|-------------------| |
|STATISTICAL TESTS | |
|-------------------| |
|LIFE TABLE | P=0.105N P=0.474 P=0.409N P=0.267N P=0.161N |
|POLY 3 | P=0.313N P=0.791N P=0.518N P=0.228N P=0.427N |
|POLY 1.5 | P=0.189N P=0.754 P=0.493N P=0.215N P=0.282N |
|POLY 6 | P=0.541N P=0.808N P=0.591N P=0.263N P=0.737N |
|LOGISTIC REGRESSION| P=0.061N P=0.677 P=0.480N P=0.212N P=0.153N |
|COCH-ARM / FISHERS | P=0.047N* P=0.691N P=0.491N P=0.211N P=0.117N |
|ORDER RESTRICTED | P=0.227N (e) (e) (e) (e) |
|=================================================================================================================================|
Date: 03/03/04 EXPERIMENT: 96020 TEST: 01 Page 50
Statistical Analysis of Non-neoplastic Lesions in Rats(SPRAGUE-DAWLEY) - TEF EVALUATION (BINARY MIXTURE; PCB 126
Terminal Sacrifice at 105 weeks
|=================================================================================================================================|
| | |
| | Females |
|Dose | 0 NG / 10 NG / 100 NG / 300 NG / 1000 NG/ |
| | 0 UG 10 UG 100 UG 300 UG 1000 UG |
|=================================================================================================================================|
| |
|Spleen |
| Pigmentation |
| |
| |
|---------------------------------------------------------------------------------------------------------------------------------|
|LESION RATES | |
|----------- | |
|OVERALL (a) | 47/53 (89%) 46/53 (87%) 43/52 (83%) 51/52 (98%) 46/50 (92%) |
|POLY-3 RATE (b) | 47/50.25 46/50.00 43/48.90 51/51.01 46/47.94 |
|POLY-3 PERCENT (g) | 93.5% 92.0% 87.9% 100.0% 96.0% |
|TERMINAL (d) | 21/22 (96%) 20/21 (95%) 21/22 (96%) 24/24 (100%) 23/24 (96%) |
|FIRST INCIDENCE | 85 178 125 254 71 |
|-------------------| |
|STATISTICAL TESTS | |
|-------------------| |
|LIFE TABLE | P=0.483N P=0.537 P=0.306N P=0.417 P=0.460N |
|POLY 3 | P=0.153 P=0.541N P=0.240N P=0.055 P=0.461 |
|POLY 1.5 | P=0.101 P=0.563N P=0.255N P=0.033 * P=0.341 |
|POLY 6 | P=0.300 P=0.510N P=0.236N P=0.156 P=0.670 |
|LOGISTIC REGRESSION| P=0.133 P=0.528N P=0.262N P=0.053 P=0.351 |
|COCH-ARM / FISHERS | P=0.163 P=0.500N P=0.276N P=0.059 P=0.408 |
|ORDER RESTRICTED | P=0.082 (e) (e) (e) (e) |
|=================================================================================================================================|
| | |
| | Females |
|Dose | 0 NG / 10 NG / 100 NG / 300 NG / 1000 NG/ |
| | 0 UG 10 UG 100 UG 300 UG 1000 UG |
|=================================================================================================================================|
| |
|Spleen: Lymphoid Follicle |
| Atrophy |
| |
| |
|---------------------------------------------------------------------------------------------------------------------------------|
|LESION RATES | |
|----------- | |
|OVERALL (a) | 0/53 (0%) 0/53 (0%) 2/52 (4%) 4/52 (8%) 5/50 (10%) |
|POLY-3 RATE (b) | 0/38.18 0/37.40 2/39.85 4/38.83 5/37.92 |
|POLY-3 PERCENT (g) | 0.0% 0.0% 5.0% 10.3% 13.2% |
|TERMINAL (d) | 0/22 (0%) 0/21 (0%) 0/22 (0%) 0/24 (0%) 0/24 (0%) |
|FIRST INCIDENCE | --- --- 491 310 574 |
|-------------------| |
|STATISTICAL TESTS | |
|-------------------| |
|LIFE TABLE | P=0.006 ** (e) P=0.242 P=0.068 P=0.028 * |
|POLY 3 | P=0.006 ** (e) P=0.246 P=0.061 P=0.029 * |
|POLY 1.5 | P=0.005 ** (e) P=0.241 P=0.060 P=0.026 * |
|POLY 6 | P=0.008 ** (e) P=0.252 P=0.064 P=0.034 * |
|LOGISTIC REGRESSION| P=0.006 ** (e) P=0.225 P=0.061 P=0.029 * |
|COCH-ARM / FISHERS | P=0.006 ** (e) P=0.243 P=0.057 P=0.024 * |
|ORDER RESTRICTED | P=0.009 ** (e) (e) (e) (e) |
|=================================================================================================================================|
Date: 03/03/04 EXPERIMENT: 96020 TEST: 01 Page 51
Statistical Analysis of Non-neoplastic Lesions in Rats(SPRAGUE-DAWLEY) - TEF EVALUATION (BINARY MIXTURE; PCB 126
Terminal Sacrifice at 105 weeks
|=================================================================================================================================|
| | |
| | Females |
|Dose | 0 NG / 10 NG / 100 NG / 300 NG / 1000 NG/ |
| | 0 UG 10 UG 100 UG 300 UG 1000 UG |
|=================================================================================================================================|
| |
|Spleen: Red Pulp |
| Atrophy |
| |
| |
|---------------------------------------------------------------------------------------------------------------------------------|
|LESION RATES | |
|----------- | |
|OVERALL (a) | 1/53 (2%) 0/53 (0%) 1/52 (2%) 0/52 (0%) 5/50 (10%) |
|POLY-3 RATE (b) | 1/38.41 0/37.40 1/39.52 0/37.39 5/38.10 |
|POLY-3 PERCENT (g) | 2.6% 0.0% 2.5% 0.0% 13.1% |
|TERMINAL (d) | 0/22 (0%) 0/21 (0%) 0/22 (0%) 0/24 (0%) 0/24 (0%) |
|FIRST INCIDENCE | 670 --- 491 --- 491 |
|-------------------| |
|STATISTICAL TESTS | |
|-------------------| |
|LIFE TABLE | P=0.002 ** P=0.493N P=0.755N P=0.500N P=0.091 |
|POLY 3 | P=0.002 ** P=0.505N P=0.755N P=0.505N P=0.097 |
|POLY 1.5 | P<0.001 ** P=0.505N P=0.759N P=0.505N P=0.090 |
|POLY 6 | P=0.002 ** P=0.505N P=0.752N P=0.505N P=0.109 |
|LOGISTIC REGRESSION| P=0.002 ** P=0.503N P=0.752 P=0.504N P=0.093 |
|COCH-ARM / FISHERS | P=0.002 ** P=0.500N P=0.748 P=0.505N P=0.090 |
|ORDER RESTRICTED | P=0.004 ** (e) (e) (e) (e) |
|=================================================================================================================================|
| | |
| | Females |
|Dose | 0 NG / 10 NG / 100 NG / 300 NG / 1000 NG/ |
| | 0 UG 10 UG 100 UG 300 UG 1000 UG |
|=================================================================================================================================|
| |
|Stomach, Forestomach |
| Hyperkeratosis |
| |
| |
|---------------------------------------------------------------------------------------------------------------------------------|
|LESION RATES | |
|----------- | |
|OVERALL (a) | 0/53 (0%) 0/53 (0%) 1/52 (2%) 2/52 (4%) 0/51 (0%) |
|POLY-3 RATE (b) | 0/38.18 0/37.40 1/38.86 2/37.84 0/36.26 |
|POLY-3 PERCENT (g) | 0.0% 0.0% 2.6% 5.3% 0.0% |
|TERMINAL (d) | 0/22 (0%) 0/21 (0%) 0/22 (0%) 0/24 (0%) 0/24 (0%) |
|FIRST INCIDENCE | --- --- 720 612 --- |
|-------------------| |
|STATISTICAL TESTS | |
|-------------------| |
|LIFE TABLE | P=0.628N (e) P=0.517 P=0.239 (e) |
|POLY 3 | P=0.636N (e) P=0.504 P=0.234 (e) |
|POLY 1.5 | P=0.639N (e) P=0.501 P=0.233 (e) |
|POLY 6 | P=0.633N (e) P=0.506 P=0.239 (e) |
|LOGISTIC REGRESSION| P=0.637N (e) P=0.508 P=0.233 (e) |
|COCH-ARM / FISHERS | P=0.633N (e) P=0.495 P=0.243 (e) |
|ORDER RESTRICTED | P=0.306 (e) (e) (e) (e) |
|=================================================================================================================================|
Date: 03/03/04 EXPERIMENT: 96020 TEST: 01 Page 52
Statistical Analysis of Non-neoplastic Lesions in Rats(SPRAGUE-DAWLEY) - TEF EVALUATION (BINARY MIXTURE; PCB 126
Terminal Sacrifice at 105 weeks
|=================================================================================================================================|
| | |
| | Females |
|Dose | 0 NG / 10 NG / 100 NG / 300 NG / 1000 NG/ |
| | 0 UG 10 UG 100 UG 300 UG 1000 UG |
|=================================================================================================================================|
| |
|Stomach, Forestomach |
| Hyperplasia |
| |
| |
|---------------------------------------------------------------------------------------------------------------------------------|
|LESION RATES | |
|----------- | |
|OVERALL (a) | 1/53 (2%) 1/53 (2%) 2/52 (4%) 7/52 (13%) 8/51 (16%) |
|POLY-3 RATE (b) | 1/38.18 1/37.89 2/39.13 7/39.86 8/37.61 |
|POLY-3 PERCENT (g) | 2.6% 2.6% 5.1% 17.6% 21.3% |
|TERMINAL (d) | 1/22 (5%) 0/21 (0%) 0/22 (0%) 1/24 (4%) 6/24 (25%) |
|FIRST INCIDENCE | 729 (T) 580 654 479 314 |
|-------------------| |
|STATISTICAL TESTS | |
|-------------------| |
|LIFE TABLE | P=0.002 ** P=0.758 P=0.505 P=0.041 * P=0.021 * |
|POLY 3 | P<0.001 ** P=0.760 P=0.509 P=0.033 * P=0.013 * |
|POLY 1.5 | P<0.001 ** P=0.758 P=0.503 P=0.030 * P=0.013 * |
|POLY 6 | P<0.001 ** P=0.760N P=0.515 P=0.038 * P=0.014 * |
|LOGISTIC REGRESSION| P<0.001 ** P=0.759 P=0.509 P=0.031 * P=0.014 * |
|COCH-ARM / FISHERS | P<0.001 ** P=0.752N P=0.493 P=0.028 * P=0.013 * |
|ORDER RESTRICTED | P=0.004 ** (e) (e) (e) (e) |
|=================================================================================================================================|
| | |
| | Females |
|Dose | 0 NG / 10 NG / 100 NG / 300 NG / 1000 NG/ |
| | 0 UG 10 UG 100 UG 300 UG 1000 UG |
|=================================================================================================================================|
| |
|Stomach, Forestomach |
| Ulcer |
| |
| |
|---------------------------------------------------------------------------------------------------------------------------------|
|LESION RATES | |
|----------- | |
|OVERALL (a) | 0/53 (0%) 0/53 (0%) 1/52 (2%) 2/52 (4%) 1/51 (2%) |
|POLY-3 RATE (b) | 0/38.18 0/37.40 1/38.82 2/37.86 1/36.65 |
|POLY-3 PERCENT (g) | 0.0% 0.0% 2.6% 5.3% 2.7% |
|TERMINAL (d) | 0/22 (0%) 0/21 (0%) 1/22 (5%) 0/24 (0%) 0/24 (0%) |
|FIRST INCIDENCE | --- --- 729 (T) 618 619 |
|-------------------| |
|STATISTICAL TESTS | |
|-------------------| |
|LIFE TABLE | P=0.377 (e) P=0.500 P=0.240 P=0.471 |
|POLY 3 | P=0.373 (e) P=0.503 P=0.234 P=0.492 |
|POLY 1.5 | P=0.367 (e) P=0.501 P=0.233 P=0.489 |
|POLY 6 | P=0.381 (e) P=0.506 P=0.239 P=0.496 |
|LOGISTIC REGRESSION| P=0.367 (e) P=0.500 P=0.233 P=0.493 |
|COCH-ARM / FISHERS | P=0.372 (e) P=0.495 P=0.243 P=0.490 |
|ORDER RESTRICTED | P=0.191 (e) (e) (e) (e) |
|=================================================================================================================================|
Date: 03/03/04 EXPERIMENT: 96020 TEST: 01 Page 53
Statistical Analysis of Non-neoplastic Lesions in Rats(SPRAGUE-DAWLEY) - TEF EVALUATION (BINARY MIXTURE; PCB 126
Terminal Sacrifice at 105 weeks
|=================================================================================================================================|
| | |
| | Females |
|Dose | 0 NG / 10 NG / 100 NG / 300 NG / 1000 NG/ |
| | 0 UG 10 UG 100 UG 300 UG 1000 UG |
|=================================================================================================================================|
| |
|Stomach, Glandular |
| Erosion |
| |
| |
|---------------------------------------------------------------------------------------------------------------------------------|
|LESION RATES | |
|----------- | |
|OVERALL (a) | 0/53 (0%) 0/53 (0%) 0/52 (0%) 1/52 (2%) 2/51 (4%) |
|POLY-3 RATE (b) | 0/38.18 0/37.40 0/38.82 1/37.39 2/37.97 |
|POLY-3 PERCENT (g) | 0.0% 0.0% 0.0% 2.7% 5.3% |
|TERMINAL (d) | 0/22 (0%) 0/21 (0%) 0/22 (0%) 1/24 (4%) 0/24 (0%) |
|FIRST INCIDENCE | --- --- --- 729 (T) 71 |
|-------------------| |
|STATISTICAL TESTS | |
|-------------------| |
|LIFE TABLE | P=0.047 * (e) (e) P=0.517 P=0.240 |
|POLY 3 | P=0.042 * (e) (e) P=0.496 P=0.235 |
|POLY 1.5 | P=0.041 * (e) (e) P=0.495 P=0.231 |
|POLY 6 | P=0.044 * (e) (e) P=0.498 P=0.240 |
|LOGISTIC REGRESSION| P=0.064 (e) (e) P=0.517 P=0.324 |
|COCH-ARM / FISHERS | P=0.040 * (e) (e) P=0.495 P=0.238 |
|ORDER RESTRICTED | P=0.047 * (e) (e) (e) (e) |
|=================================================================================================================================|
| | |
| | Females |
|Dose | 0 NG / 10 NG / 100 NG / 300 NG / 1000 NG/ |
| | 0 UG 10 UG 100 UG 300 UG 1000 UG |
|=================================================================================================================================|
| |
|Stomach, Glandular |
| Mineralization |
| |
| |
|---------------------------------------------------------------------------------------------------------------------------------|
|LESION RATES | |
|----------- | |
|OVERALL (a) | 4/53 (8%) 3/53 (6%) 3/52 (6%) 1/52 (2%) 0/51 (0%) |
|POLY-3 RATE (b) | 4/38.98 3/39.05 3/39.36 1/37.99 0/36.26 |
|POLY-3 PERCENT (g) | 10.3% 7.7% 7.6% 2.6% 0.0% |
|TERMINAL (d) | 2/22 (9%) 0/21 (0%) 1/22 (5%) 0/24 (0%) 0/24 (0%) |
|FIRST INCIDENCE | 556 534 654 539 --- |
|-------------------| |
|STATISTICAL TESTS | |
|-------------------| |
|LIFE TABLE | P=0.045N* P=0.510N P=0.505N P=0.183N P=0.065N |
|POLY 3 | P=0.046N* P=0.499N P=0.495N P=0.184N P=0.069N |
|POLY 1.5 | P=0.045N* P=0.505N P=0.500N P=0.186N P=0.069N |
|POLY 6 | P=0.046N* P=0.489N P=0.490N P=0.182N P=0.068N |
|LOGISTIC REGRESSION| P=0.044N* P=0.499N P=0.496N P=0.186N P=0.069N |
|COCH-ARM / FISHERS | P=0.043N* P=0.500N P=0.511N P=0.187N P=0.064N |
|ORDER RESTRICTED | P=0.041N* (e) (e) (e) (e) |
|=================================================================================================================================|
Date: 03/03/04 EXPERIMENT: 96020 TEST: 01 Page 54
Statistical Analysis of Non-neoplastic Lesions in Rats(SPRAGUE-DAWLEY) - TEF EVALUATION (BINARY MIXTURE; PCB 126
Terminal Sacrifice at 105 weeks
|=================================================================================================================================|
| | |
| | Females |
|Dose | 0 NG / 10 NG / 100 NG / 300 NG / 1000 NG/ |
| | 0 UG 10 UG 100 UG 300 UG 1000 UG |
|=================================================================================================================================|
| |
|Thymus |
| Atrophy |
| |
| |
|---------------------------------------------------------------------------------------------------------------------------------|
|LESION RATES | |
|----------- | |
|OVERALL (a) | 33/53 (62%) 33/50 (66%) 43/48 (90%) 42/50 (84%) 49/51 (96%) |
|POLY-3 RATE (b) | 33/43.47 33/41.83 43/45.48 42/43.09 49/49.02 |
|POLY-3 PERCENT (g) | 75.9% 78.9% 94.6% 97.5% 100.0% |
|TERMINAL (d) | 18/22 (82%) 14/19 (74%) 18/19 (95%) 24/24 (100%) 24/24 (100%) |
|FIRST INCIDENCE | 449 167 125 479 71 |
|-------------------| |
|STATISTICAL TESTS | |
|-------------------| |
|LIFE TABLE | P=0.026 * P=0.409 P=0.047 * P=0.142 P=0.017 * |
|POLY 3 | P<0.001 ** P=0.470 P=0.006 ** P<0.001 ** P<0.001 ** |
|POLY 1.5 | P<0.001 ** P=0.439 P=0.002 ** P<0.001 ** P<0.001 ** |
|POLY 6 | P<0.001 ** P=0.519 P=0.020 * P=0.002 ** P<0.001 ** |
|LOGISTIC REGRESSION| P<0.001 ** P=0.322 P<0.001 ** P<0.001 ** P<0.001 ** |
|COCH-ARM / FISHERS | P<0.001 ** P=0.425 P<0.001 ** P=0.011 * P<0.001 ** |
|ORDER RESTRICTED | P<0.001 ** (e) (e) (e) (e) |
|=================================================================================================================================|
| | |
| | Females |
|Dose | 0 NG / 10 NG / 100 NG / 300 NG / 1000 NG/ |
| | 0 UG 10 UG 100 UG 300 UG 1000 UG |
|=================================================================================================================================|
| |
|Thymus |
| Hemorrhage |
| |
| |
|---------------------------------------------------------------------------------------------------------------------------------|
|LESION RATES | |
|----------- | |
|OVERALL (a) | 1/53 (2%) 0/50 (0%) 0/48 (0%) 3/50 (6%) 1/51 (2%) |
|POLY-3 RATE (b) | 1/39.00 0/34.71 0/34.86 3/38.30 1/36.76 |
|POLY-3 PERCENT (g) | 2.6% 0.0% 0.0% 7.8% 2.7% |
|TERMINAL (d) | 0/22 (0%) 0/19 (0%) 0/19 (0%) 0/24 (0%) 0/24 (0%) |
|FIRST INCIDENCE | 418 --- --- 96 76 |
|-------------------| |
|STATISTICAL TESTS | |
|-------------------| |
|LIFE TABLE | P=0.420 P=0.521N P=0.500N P=0.296 P=0.751 |
|POLY 3 | P=0.439 P=0.523N P=0.522N P=0.298 P=0.748 |
|POLY 1.5 | P=0.432 P=0.521N P=0.521N P=0.292 P=0.746 |
|POLY 6 | P=0.451 P=0.524N P=0.525N P=0.307 P=0.752 |
|LOGISTIC REGRESSION| P=0.610N P=0.479N P=0.527N P=0.429 P=0.613N |
|COCH-ARM / FISHERS | P=0.436 P=0.515N P=0.525N P=0.287 P=0.743 |
|ORDER RESTRICTED | P=0.191 (e) (e) (e) (e) |
|=================================================================================================================================|
Date: 03/03/04 EXPERIMENT: 96020 TEST: 01 Page 55
Statistical Analysis of Non-neoplastic Lesions in Rats(SPRAGUE-DAWLEY) - TEF EVALUATION (BINARY MIXTURE; PCB 126
Terminal Sacrifice at 105 weeks
|=================================================================================================================================|
| | |
| | Females |
|Dose | 0 NG / 10 NG / 100 NG / 300 NG / 1000 NG/ |
| | 0 UG 10 UG 100 UG 300 UG 1000 UG |
|=================================================================================================================================|
| |
|Thymus |
| Hyperplasia Lymphoid |
| |
| |
|---------------------------------------------------------------------------------------------------------------------------------|
|LESION RATES | |
|----------- | |
|OVERALL (a) | 2/53 (4%) 0/50 (0%) 0/48 (0%) 0/50 (0%) 0/51 (0%) |
|POLY-3 RATE (b) | 2/39.43 0/34.71 0/34.86 0/35.50 0/35.76 |
|POLY-3 PERCENT (g) | 5.1% 0.0% 0.0% 0.0% 0.0% |
|TERMINAL (d) | 0/22 (0%) 0/19 (0%) 0/19 (0%) 0/24 (0%) 0/24 (0%) |
|FIRST INCIDENCE | 85 --- --- --- --- |
|-------------------| |
|STATISTICAL TESTS | |
|-------------------| |
|LIFE TABLE | P=0.355N P=0.247N P=0.247N P=0.251N P=0.259N |
|POLY 3 | P=0.331N P=0.266N P=0.264N P=0.260N P=0.259N |
|POLY 1.5 | P=0.334N P=0.263N P=0.263N P=0.261N P=0.260N |
|POLY 6 | P=0.327N P=0.267N P=0.267N P=0.258N P=0.256N |
|LOGISTIC REGRESSION| P=0.262N P=0.195N P=0.254N P=0.180N P=0.146N |
|COCH-ARM / FISHERS | P=0.342N P=0.262N P=0.273N P=0.262N P=0.257N |
|ORDER RESTRICTED | P=0.022N* (e) (e) (e) (e) |
|=================================================================================================================================|
| | |
| | Females |
|Dose | 0 NG / 10 NG / 100 NG / 300 NG / 1000 NG/ |
| | 0 UG 10 UG 100 UG 300 UG 1000 UG |
|=================================================================================================================================|
| |
|Thyroid Gland: C-Cell |
| Hyperplasia |
| |
| |
|---------------------------------------------------------------------------------------------------------------------------------|
|LESION RATES | |
|----------- | |
|OVERALL (a) | 15/53 (28%) 19/53 (36%) 22/51 (43%) 12/52 (23%) 15/52 (29%) |
|POLY-3 RATE (b) | 15/41.78 19/39.63 22/42.21 12/38.36 15/39.51 |
|POLY-3 PERCENT (g) | 35.9% 48.0% 52.1% 31.3% 38.0% |
|TERMINAL (d) | 7/22 (32%) 13/21 (62%) 13/22 (59%) 7/24 (29%) 7/24 (29%) |
|FIRST INCIDENCE | 377 407 407 552 479 |
|-------------------| |
|STATISTICAL TESTS | |
|-------------------| |
|LIFE TABLE | P=0.199N P=0.235 P=0.140 P=0.307N P=0.565N |
|POLY 3 | P=0.264N P=0.183 P=0.093 P=0.419N P=0.515 |
|POLY 1.5 | P=0.282N P=0.205 P=0.091 P=0.405N P=0.504 |
|POLY 6 | P=0.236N P=0.164 P=0.095 P=0.422N P=0.537 |
|LOGISTIC REGRESSION| P=0.289N P=0.238 P=0.103 P=0.367N P=0.526 |
|COCH-ARM / FISHERS | P=0.245N P=0.266 P=0.084 P=0.349N P=0.561 |
|ORDER RESTRICTED | P=0.268N (e) (e) (e) (e) |
|=================================================================================================================================|
Date: 03/03/04 EXPERIMENT: 96020 TEST: 01 Page 56
Statistical Analysis of Non-neoplastic Lesions in Rats(SPRAGUE-DAWLEY) - TEF EVALUATION (BINARY MIXTURE; PCB 126
Terminal Sacrifice at 105 weeks
|=================================================================================================================================|
| | |
| | Females |
|Dose | 0 NG / 10 NG / 100 NG / 300 NG / 1000 NG/ |
| | 0 UG 10 UG 100 UG 300 UG 1000 UG |
|=================================================================================================================================|
| |
|Thyroid Gland: Follicle |
| Cyst |
| |
| |
|---------------------------------------------------------------------------------------------------------------------------------|
|LESION RATES | |
|----------- | |
|OVERALL (a) | 2/53 (4%) 0/53 (0%) 0/51 (0%) 0/52 (0%) 0/52 (0%) |
|POLY-3 RATE (b) | 2/38.43 0/37.40 0/38.82 0/36.79 0/36.27 |
|POLY-3 PERCENT (g) | 5.2% 0.0% 0.0% 0.0% 0.0% |
|TERMINAL (d) | 1/22 (5%) 0/21 (0%) 0/22 (0%) 0/24 (0%) 0/24 (0%) |
|FIRST INCIDENCE | 664 --- --- --- --- |
|-------------------| |
|STATISTICAL TESTS | |
|-------------------| |
|LIFE TABLE | P=0.342N P=0.252N P=0.247N P=0.241N P=0.245N |
|POLY 3 | P=0.346N P=0.242N P=0.234N P=0.246N P=0.249N |
|POLY 1.5 | P=0.346N P=0.242N P=0.237N P=0.247N P=0.251N |
|POLY 6 | P=0.346N P=0.242N P=0.233N P=0.244N P=0.247N |
|LOGISTIC REGRESSION| P=0.350N P=0.241N P=0.232N P=0.243N P=0.247N |
|COCH-ARM / FISHERS | P=0.345N P=0.248N P=0.257N P=0.252N P=0.252N |
|ORDER RESTRICTED | P=0.019N* (e) (e) (e) (e) |
|=================================================================================================================================|
| | |
| | Females |
|Dose | 0 NG / 10 NG / 100 NG / 300 NG / 1000 NG/ |
| | 0 UG 10 UG 100 UG 300 UG 1000 UG |
|=================================================================================================================================|
| |
|Thyroid Gland: Follicular Cell |
| Hypertrophy |
| |
| |
|---------------------------------------------------------------------------------------------------------------------------------|
|LESION RATES | |
|----------- | |
|OVERALL (a) | 14/53 (26%) 17/53 (32%) 34/51 (67%) 35/52 (67%) 42/52 (81%) |
|POLY-3 RATE (b) | 14/43.47 17/41.12 34/46.24 35/45.78 42/45.75 |
|POLY-3 PERCENT (g) | 32.2% 41.3% 73.5% 76.5% 91.8% |
|TERMINAL (d) | 5/22 (23%) 8/21 (38%) 17/22 (77%) 20/24 (83%) 23/24 (96%) |
|FIRST INCIDENCE | 418 330 254 142 71 |
|-------------------| |
|STATISTICAL TESTS | |
|-------------------| |
|LIFE TABLE | P<0.001 ** P=0.325 P<0.001 ** P<0.001 ** P<0.001 ** |
|POLY 3 | P<0.001 ** P=0.256 P<0.001 ** P<0.001 ** P<0.001 ** |
|POLY 1.5 | P<0.001 ** P=0.277 P<0.001 ** P<0.001 ** P<0.001 ** |
|POLY 6 | P<0.001 ** P=0.242 P<0.001 ** P<0.001 ** P<0.001 ** |
|LOGISTIC REGRESSION| P<0.001 ** P=0.330 P<0.001 ** P<0.001 ** P<0.001 ** |
|COCH-ARM / FISHERS | P<0.001 ** P=0.335 P<0.001 ** P<0.001 ** P<0.001 ** |
|ORDER RESTRICTED | P<0.001 ** (e) (e) (e) (e) |
|=================================================================================================================================|
Date: 03/03/04 EXPERIMENT: 96020 TEST: 01 Page 57
Statistical Analysis of Non-neoplastic Lesions in Rats(SPRAGUE-DAWLEY) - TEF EVALUATION (BINARY MIXTURE; PCB 126
Terminal Sacrifice at 105 weeks
|=================================================================================================================================|
| | |
| | Females |
|Dose | 0 NG / 10 NG / 100 NG / 300 NG / 1000 NG/ |
| | 0 UG 10 UG 100 UG 300 UG 1000 UG |
|=================================================================================================================================|
| |
|Tooth: Peridontal Tissue |
| Inflammation |
| |
| |
|---------------------------------------------------------------------------------------------------------------------------------|
|LESION RATES | |
|----------- | |
|OVERALL (a) | 23/23 (100%) 14/14 (100%) 33/33 (100%) 35/35 (100%) 31/31 (100%) |
|POLY-3 RATE (b) | 23/23.00 14/14.00 33/33.00 35/35.00 31/31.00 |
|POLY-3 PERCENT (g) | 100.0% 100.0% 100.0% 100.0% 100.0% |
|TERMINAL (d) | 10/10 (100%) 8/8 (100%) 16/16 (100%) 17/17 (100%) 17/17 (100%) |
|FIRST INCIDENCE | 451 499 407 254 169 |
|-------------------| |
|STATISTICAL TESTS | |
|-------------------| |
|LIFE TABLE | (e) (e) (e) (e) (e) |
|POLY 3 | (e) (e) (e) (e) (e) |
|POLY 1.5 | (e) (e) (e) (e) (e) |
|POLY 6 | (e) (e) (e) (e) (e) |
|LOGISTIC REGRESSION| (e) (e) (e) (e) (e) |
|COCH-ARM / FISHERS | (e) (e) (e) (e) (e) |
|ORDER RESTRICTED | (e) (e) (e) (e) (e) |
|=================================================================================================================================|
| | |
| | Females |
|Dose | 0 NG / 10 NG / 100 NG / 300 NG / 1000 NG/ |
| | 0 UG 10 UG 100 UG 300 UG 1000 UG |
|=================================================================================================================================|
| |
|Urinary Bladder |
| Inflammation |
| |
| |
|---------------------------------------------------------------------------------------------------------------------------------|
|LESION RATES | |
|----------- | |
|OVERALL (a) | 7/53 (13%) 8/53 (15%) 5/53 (9%) 7/52 (13%) 0/50 (0%) |
|POLY-3 RATE (b) | 7/40.77 8/40.04 5/41.06 7/39.03 0/35.82 |
|POLY-3 PERCENT (g) | 17.2% 20.0% 12.2% 17.9% 0.0% |
|TERMINAL (d) | 3/22 (14%) 1/21 (5%) 2/22 (9%) 4/24 (17%) 0/24 (0%) |
|FIRST INCIDENCE | 345 469 254 499 --- |
|-------------------| |
|STATISTICAL TESTS | |
|-------------------| |
|LIFE TABLE | P=0.008N** P=0.488 P=0.388N P=0.589N P=0.011N* |
|POLY 3 | P=0.010N* P=0.485 P=0.372N P=0.581 P=0.012N* |
|POLY 1.5 | P=0.010N* P=0.479 P=0.373N P=0.582 P=0.012N* |
|POLY 6 | P=0.010N* P=0.507 P=0.373N P=0.589 P=0.012N* |
|LOGISTIC REGRESSION| P=0.008N** P=0.506 P=0.391N P=0.599 P=0.011N* |
|COCH-ARM / FISHERS | P=0.008N** P=0.500 P=0.380N P=0.598 P=0.008N** |
|ORDER RESTRICTED | P=0.013N* (e) (e) (e) (e) |
|=================================================================================================================================|
Date: 03/03/04 EXPERIMENT: 96020 TEST: 01 Page 58
Statistical Analysis of Non-neoplastic Lesions in Rats(SPRAGUE-DAWLEY) - TEF EVALUATION (BINARY MIXTURE; PCB 126
Terminal Sacrifice at 105 weeks
|=================================================================================================================================|
| | |
| | Females |
|Dose | 0 NG / 10 NG / 100 NG / 300 NG / 1000 NG/ |
| | 0 UG 10 UG 100 UG 300 UG 1000 UG |
|=================================================================================================================================|
| |
|Uterus |
| Inflammation |
| |
| |
|---------------------------------------------------------------------------------------------------------------------------------|
|LESION RATES | |
|----------- | |
|OVERALL (a) | 3/53 (6%) 5/53 (9%) 8/53 (15%) 10/52 (19%) 5/50 (10%) |
|POLY-3 RATE (b) | 3/39.57 5/38.45 8/39.64 10/39.56 5/36.31 |
|POLY-3 PERCENT (g) | 7.6% 13.0% 20.2% 25.3% 13.8% |
|TERMINAL (d) | 0/22 (0%) 3/21 (14%) 6/22 (27%) 6/24 (25%) 4/24 (17%) |
|FIRST INCIDENCE | 345 337 638 506 581 |
|-------------------| |
|STATISTICAL TESTS | |
|-------------------| |
|LIFE TABLE | P=0.560N P=0.341 P=0.101 P=0.046 * P=0.352 |
|POLY 3 | P=0.477 P=0.339 P=0.094 P=0.031 * P=0.308 |
|POLY 1.5 | P=0.470 P=0.342 P=0.096 P=0.031 * P=0.306 |
|POLY 6 | P=0.488 P=0.337 P=0.093 P=0.033 * P=0.311 |
|LOGISTIC REGRESSION| P=0.490 P=0.360 P=0.105 P=0.035 * P=0.320 |
|COCH-ARM / FISHERS | P=0.497 P=0.358 P=0.101 P=0.033 * P=0.325 |
|ORDER RESTRICTED | P=0.113 (e) (e) (e) (e) |
|=================================================================================================================================|
| | |
| | Females |
|Dose | 0 NG / 10 NG / 100 NG / 300 NG / 1000 NG/ |
| | 0 UG 10 UG 100 UG 300 UG 1000 UG |
|=================================================================================================================================|
| |
|Uterus |
| Inflammation Chronic |
| |
| |
|---------------------------------------------------------------------------------------------------------------------------------|
|LESION RATES | |
|----------- | |
|OVERALL (a) | 3/53 (6%) 0/53 (0%) 1/53 (2%) 7/52 (13%) 2/50 (4%) |
|POLY-3 RATE (b) | 3/38.79 0/37.40 1/39.09 7/39.10 2/36.51 |
|POLY-3 PERCENT (g) | 7.7% 0.0% 2.6% 17.9% 5.5% |
|TERMINAL (d) | 2/22 (9%) 0/21 (0%) 0/22 (0%) 2/24 (8%) 1/24 (4%) |
|FIRST INCIDENCE | 533 --- 715 310 491 |
|-------------------| |
|STATISTICAL TESTS | |
|-------------------| |
|LIFE TABLE | P=0.452 P=0.128N P=0.293N P=0.181 P=0.479N |
|POLY 3 | P=0.419 P=0.124N P=0.301N P=0.156 P=0.528N |
|POLY 1.5 | P=0.407 P=0.124N P=0.303N P=0.153 P=0.534N |
|POLY 6 | P=0.436 P=0.124N P=0.301N P=0.165 P=0.519N |
|LOGISTIC REGRESSION| P=0.407 P=0.123N P=0.298N P=0.151 P=0.530N |
|COCH-ARM / FISHERS | P=0.411 P=0.121N P=0.309N P=0.152 P=0.528N |
|ORDER RESTRICTED | P=0.113 (e) (e) (e) (e) |
|=================================================================================================================================|
Date: 03/03/04 EXPERIMENT: 96020 TEST: 01 Page 59
Statistical Analysis of Non-neoplastic Lesions in Rats(SPRAGUE-DAWLEY) - TEF EVALUATION (BINARY MIXTURE; PCB 126
Terminal Sacrifice at 105 weeks
|=================================================================================================================================|
| | |
| | Females |
|Dose | 0 NG / 10 NG / 100 NG / 300 NG / 1000 NG/ |
| | 0 UG 10 UG 100 UG 300 UG 1000 UG |
|=================================================================================================================================|
| |
|Uterus |
| Metaplasia |
| |
| |
|---------------------------------------------------------------------------------------------------------------------------------|
|LESION RATES | |
|----------- | |
|OVERALL (a) | 27/53 (51%) 30/53 (57%) 35/53 (66%) 36/52 (69%) 14/50 (28%) |
|POLY-3 RATE (b) | 27/44.63 30/45.71 35/49.50 36/44.30 14/38.69 |
|POLY-3 PERCENT (g) | 60.5% 65.6% 70.7% 81.3% 36.2% |
|TERMINAL (d) | 12/22 (55%) 13/21 (62%) 15/22 (68%) 21/24 (88%) 7/24 (29%) |
|FIRST INCIDENCE | 345 330 254 310 477 |
|-------------------| |
|STATISTICAL TESTS | |
|-------------------| |
|LIFE TABLE | P<0.001N** P=0.329 P=0.164 P=0.133 P=0.017N* |
|POLY 3 | P<0.001N** P=0.382 P=0.196 P=0.018 * P=0.018N* |
|POLY 1.5 | P<0.001N** P=0.356 P=0.144 P=0.024 * P=0.017N* |
|POLY 6 | P=0.002N** P=0.411 P=0.251 P=0.012 * P=0.021N* |
|LOGISTIC REGRESSION| P<0.001N** P=0.329 P=0.085 P=0.036 * P=0.016N* |
|COCH-ARM / FISHERS | P<0.001N** P=0.349 P=0.084 P=0.043 * P=0.014N* |
|ORDER RESTRICTED | P<0.001N** (e) (e) (e) (e) |
|=================================================================================================================================|
| | |
| | Females |
|Dose | 0 NG / 10 NG / 100 NG / 300 NG / 1000 NG/ |
| | 0 UG 10 UG 100 UG 300 UG 1000 UG |
|=================================================================================================================================|
| |
|Uterus: Endometrium |
| Hyperplasia Cystic |
| |
| |
|---------------------------------------------------------------------------------------------------------------------------------|
|LESION RATES | |
|----------- | |
|OVERALL (a) | 28/53 (53%) 23/53 (43%) 34/53 (64%) 18/52 (35%) 12/50 (24%) |
|POLY-3 RATE (b) | 28/44.64 23/42.81 34/46.65 18/41.18 12/36.59 |
|POLY-3 PERCENT (g) | 62.7% 53.7% 72.9% 43.7% 32.8% |
|TERMINAL (d) | 13/22 (59%) 12/21 (57%) 19/22 (86%) 13/24 (54%) 10/24 (42%) |
|FIRST INCIDENCE | 345 296 254 142 581 |
|-------------------| |
|STATISTICAL TESTS | |
|-------------------| |
|LIFE TABLE | P<0.001N** P=0.299N P=0.223 P=0.040N* P=0.002N** |
|POLY 3 | P<0.001N** P=0.253N P=0.193 P=0.051N P=0.004N** |
|POLY 1.5 | P<0.001N** P=0.248N P=0.177 P=0.044N* P=0.003N** |
|POLY 6 | P<0.001N** P=0.253N P=0.213 P=0.066N P=0.006N** |
|LOGISTIC REGRESSION| P<0.001N** P=0.234N P=0.169 P=0.046N* P=0.002N** |
|COCH-ARM / FISHERS | P<0.001N** P=0.218N P=0.162 P=0.046N* P=0.002N** |
|ORDER RESTRICTED | P=0.003N** (e) (e) (e) (e) |
|=================================================================================================================================|
(a) Number of tumor-bearing animals / number of animals examined at site.
(b) Number of tumor-bearing animals / Poly-3 number
(d) Observed incidence at terminal kill.
(f) Beneath the control incidence are the P-values associated with the trend
test. Beneath the dosed group incidence are the P-values corresponding to
pairwise comparisons between the controls and that dosed group. The life
table analysis regards tumors in animals dying prior to terminal kill as
being (directly or indirectly) the cause of death.
Logistic regression is an alternative
method for analyzing the incidence of non-fatal tumors. The Cochran-Armitage
and Fishers exact tests compare directly the overall incidence rates
For all tests a negative trend is indicated by N
(e) Value of Statistic cannot be computed.
(g) Poly-3 adjusted lifetime tumor incidence.
(I) Interim sacrifice
(T) Terminal sacrifice
# Tumor rates based on number of animals necropsied.
* To the right of any statistical result, indicates significance at (P<=0.05).
** To the right of any statistical result, indicates significance at (P<=0.01).