https://ntp.niehs.nih.gov/go/18206

TDMS Study 96020-01 Pathology Tables

NTP Experiment-Test: 96020-01         INCIDENCE RATES OF NONNEOPLASTIC LESIONS BY ANATOMIC SITE (a)               Report: PEIRPT18
Study Type: CHRONIC                                  WITH AVERAGE SEVERITY GRADES[b]                              Date: 03/03/04
Route: GAVAGE                                  TEF EVALUATION (BINARY MIXTURE; PCB 126/PCB 153)                   Time: 10:12:20
                                                            FINAL #1
       Facility:  Battelle Columbus Laboratory
       Chemical CAS #:  TEFBINARYMIX
       Lock Date:  03/27/02
       Cage Range:  All
       Reasons For Removal:    25018 Dosing Accident                   25019 Moribund Sacrifice
                               25020 Natural Death                     25021 Terminal Sacrifice
       Removal Date Range:     All
       Treatment Groups:       Include 001    0 NG /  0 UG
                               Include 004    300 NG /100 UG
                               Include 005    300 NG /300 UG
                               Include 006    300 NG /3000 UG
a  Number of animals examined microscopically at site and number of animals with lesion
b  Average severity grade (1-minimal;2-mild;3-moderate;4-marked)
                                                              Page   1
NTP Experiment-Test: 96020-01         INCIDENCE RATES OF NONNEOPLASTIC LESIONS BY ANATOMIC SITE (a)               Report: PEIRPT18  
Study Type: CHRONIC                                  WITH AVERAGE SEVERITY GRADES[b]                              Date: 03/03/04    
Route: GAVAGE                                  TEF EVALUATION (BINARY MIXTURE; PCB 126/PCB 153)                   Time: 10:12:20    
____________________________________________________________________________________________________________________________________
         SPRAGUE-DAWLEY RATS FEMALE                   0 NG /       300 NG /     300 NG /     300 NG /                               
                                                      0 UG         100 UG       300 UG       3000 UG                                
____________________________________________________________________________________________________________________________________
DISPOSITION SUMMARY                                                                                                                 
  Animals Initially In Study                          98           80           98           80                                     
  Early Deaths                                                                                                                      
    Moribund Sacrifice                                22           10           19           13                                     
    Natural Death                                      8           12           10           10                                     
    Dosing Accident                                    1                                      1                                     
  Survivors                                                                                                                         
    Terminal Sacrifice                                22           28           24           27                                     
  Animals Examined Microscopically                    53           50           53           51                                     
____________________________________________________________________________________________________________________________________
 ALIMENTARY SYSTEM                                                                                                                  
   Esophagus                                          (53)         (50)         (53)         (50)                                   
      Perforation                                                                             1 [3.0]                               
      Muscularis, Inflammation                         3 [1.3]                   3 [1.3]                                            
      Periesophageal Tissue, Hemorrhage                                                       1 [2.0]                               
      Periesophageal Tissue, Inflammation                           1 [3.0]                   1 [3.0]                               
   Intestine Large, Rectum                            (53)         (50)         (53)         (51)                                   
      Parasite Metazoan                                2            1            1            2                                     
      Artery, Inflammation, Chronic Active                          1 [2.0]                   2 [2.5]                               
   Intestine Large, Cecum                             (53)         (50)         (52)         (50)                                   
      Edema                                                                                   1 [2.0]                               
      Inflammation                                                  1 [2.0]                                                         
      Artery, Inflammation                                          1 [2.0]                                                         
      Artery, Inflammation, Chronic Active                                                    1 [2.0]                               
      Artery, Thrombosis                                            1 [3.0]                                                         
      Lymphoid Tissue, Hyperplasia                                  1 [3.0]                                                         
   Intestine Small, Jejunum                           (53)         (50)         (52)         (51)                                   
      Hyperplasia, Lymphoid                                                      2 [3.5]                                            
      Ulcer                                                                      1 [4.0]                                            
   Intestine Small, Ileum                             (53)         (50)         (52)         (50)                                   
      Hyperplasia, Lymphoid                            1 [2.0]                                                                      
   Liver                                              (53)         (50)         (52)         (51)                                   
      Angiectasis                                      3 [1.7]      1 [2.0]      2 [2.0]      3 [2.0]                               
      Basophilic Focus                                 9            4            2            8                                     
      Basophilic Focus, Multiple                      13            1            1           10                                     
      Cholangiofibrosis                                             5 [2.4]      7 [2.0]     13 [2.2]                               
      Clear Cell Focus                                 3            1            3            5                                     
      Clear Cell Focus, Multiple                       6            4                         6                                     
      Eosinophilic Focus                               7            6            7                                                  
      Eosinophilic Focus, Multiple                     7           21           33           45                                     
a  Number of animals examined microscopically at site and number of animals with lesion                                             
b  Average severity grade (1-minimal;2-mild;3-moderate;4-marked)                                                                    
                                                             Page    2                                                              
NTP Experiment-Test: 96020-01         INCIDENCE RATES OF NONNEOPLASTIC LESIONS BY ANATOMIC SITE (a)               Report: PEIRPT18  
Study Type: CHRONIC                                  WITH AVERAGE SEVERITY GRADES[b]                              Date: 03/03/04    
Route: GAVAGE                                  TEF EVALUATION (BINARY MIXTURE; PCB 126/PCB 153)                   Time: 10:12:20    
____________________________________________________________________________________________________________________________________
         SPRAGUE-DAWLEY RATS FEMALE                   0 NG /       300 NG /     300 NG /     300 NG /                               
                                                      0 UG         100 UG       300 UG       3000 UG                                
____________________________________________________________________________________________________________________________________
ALIMENTARY SYSTEM - CONT                                                                                                            
      Fatty Change, Diffuse                            3 [1.7]     28 [1.1]     31 [1.5]     47 [1.5]                               
      Fatty Change, Focal                              3 [1.0]      4 [1.3]      1 [2.0]     11 [1.9]                               
      Hematopoietic Cell Proliferation                27 [1.2]     18 [1.1]     19 [1.1]     29 [1.1]                               
      Hemorrhage                                                                              1 [3.0]                               
      Hyperplasia, Nodular                                         20           24           21                                     
      Inflammation                                    44 [1.1]     47 [1.2]     48 [1.2]     46 [1.2]                               
      Mixed Cell Focus                                 7                         2            1                                     
      Mixed Cell Focus, Multiple                      19           27           24           26                                     
      Necrosis                                         4 [1.8]      6 [2.5]      4 [1.0]      7 [2.1]                               
      Pigmentation                                     2 [1.0]     50 [1.9]     50 [1.9]     44 [1.8]                               
      Toxic Hepatopathy                                            44 [1.6]     48 [2.0]     48 [2.8]                               
      Bile Duct, Cyst                                  4 [2.3]      4 [1.8]      5 [2.4]      6 [2.5]                               
      Bile Duct, Fibrosis                              1 [1.0]                   4 [1.0]      5 [1.6]                               
      Bile Duct, Hyperplasia                           8 [1.3]     20 [1.2]     29 [1.4]     40 [1.7]                               
      Centrilobular, Degeneration                      5 [1.8]      6 [2.5]      4 [1.5]      2 [3.0]                               
      Centrilobular, Fibrosis                                       1 [2.0]      1 [1.0]                                            
      Hepatocyte, Hypertrophy                          1 [1.0]     22 [2.1]     33 [2.1]     47 [3.0]                               
      Hepatocyte, Multinucleated                                   42 [1.4]     46 [1.6]     44 [1.5]                               
      Oval Cell, Hyperplasia                           2 [1.0]     33 [1.3]     39 [1.6]     43 [2.1]                               
      Portal, Fibrosis                                              3 [1.3]      7 [1.4]     10 [1.6]                               
      Serosa, Inflammation, Chronic Active             1 [3.0]                                                                      
   Mesentery                                          (47)         (31)         (47)         (47)                                   
      Artery, Inflammation, Chronic Active             1 [1.0]      1 [3.0]      2 [2.5]      1 [3.0]                               
      Fat, Necrosis                                                              1 [3.0]                                            
   Oral Mucosa                                        (12)         (28)         (30)         (41)                                   
      Gingival, Hyperplasia, Squamous                  8 [1.3]     21 [1.6]     22 [1.6]     29 [1.5]                               
   Pancreas                                           (53)         (49)         (52)         (49)                                   
      Inflammation, Chronic Active                                  5 [1.2]      1 [1.0]      5 [1.8]                               
      Necrosis                                                                                1 [1.0]                               
      Acinus, Atrophy                                               4 [1.8]      1 [1.0]      5 [2.0]                               
      Acinus, Hyperplasia                              2 [1.5]                   1 [3.0]      1 [2.0]                               
      Acinus, Vacuolization Cytoplasmic                             3 [1.0]      7 [1.0]     44 [1.5]                               
      Artery, Inflammation, Chronic Active                          4 [2.0]      2 [2.5]      3 [1.7]                               
   Stomach, Forestomach                               (53)         (50)         (52)         (51)                                   
      Cyst                                                          1 [2.0]                                                         
      Hyperkeratosis                                                             2 [2.0]      2 [2.0]                               
      Hyperplasia, Squamous                            1 [2.0]      6 [2.0]      7 [2.0]      9 [2.0]                               
      Inflammation                                                               1 [2.0]      6 [1.8]                               
      Mineralization                                   1 [1.0]                                                                      
      Ulcer                                                         1 [1.0]      2 [2.5]      1 [2.0]                               
      Artery, Inflammation, Chronic Active                                                    2 [2.0]                               
   Stomach, Glandular                                 (53)         (50)         (52)         (51)                                   
      Ectopic Tissue                                                             1 [4.0]                                            
a  Number of animals examined microscopically at site and number of animals with lesion                                             
b  Average severity grade (1-minimal;2-mild;3-moderate;4-marked)                                                                    
                                                             Page    3                                                              
NTP Experiment-Test: 96020-01         INCIDENCE RATES OF NONNEOPLASTIC LESIONS BY ANATOMIC SITE (a)               Report: PEIRPT18  
Study Type: CHRONIC                                  WITH AVERAGE SEVERITY GRADES[b]                              Date: 03/03/04    
Route: GAVAGE                                  TEF EVALUATION (BINARY MIXTURE; PCB 126/PCB 153)                   Time: 10:12:20    
____________________________________________________________________________________________________________________________________
         SPRAGUE-DAWLEY RATS FEMALE                   0 NG /       300 NG /     300 NG /     300 NG /                               
                                                      0 UG         100 UG       300 UG       3000 UG                                
____________________________________________________________________________________________________________________________________
ALIMENTARY SYSTEM - CONT                                                                                                            
      Erosion                                                       3 [2.0]      1 [2.0]                                            
      Mineralization                                   4 [1.5]      1 [1.0]      1 [2.0]                                            
   Tooth                                              (23)         (25)         (35)         (42)                                   
      Peridontal Tissue, Inflammation                 23 [1.2]     25 [1.3]     35 [1.5]     42 [1.4]                               
____________________________________________________________________________________________________________________________________
 CARDIOVASCULAR SYSTEM                                                                                                              
   Blood Vessel                                       (53)         (50)         (53)         (51)                                   
      Aorta, Mineralization                                                      1 [3.0]                                            
   Heart                                              (53)         (50)         (53)         (50)                                   
      Cardiomyopathy                                  22 [1.0]     18 [1.1]     26 [1.1]     25 [1.0]                               
      Inflammation, Chronic Active                     1 [4.0]                                                                      
      Mineralization                                                1 [2.0]                                                         
      Thrombosis                                                    1 [3.0]                                                         
      Coronary Artery, Inflammation, Chronic Active                 1 [2.0]                                                         
      Endocardium, Hyperplasia                                      1 [1.0]                                                         
      Pericardium, Necrosis                                                      1 [3.0]                                            
____________________________________________________________________________________________________________________________________
 ENDOCRINE SYSTEM                                                                                                                   
   Adrenal Cortex                                     (53)         (49)         (52)         (51)                                   
      Angiectasis                                     17 [1.4]     28 [1.6]     23 [1.7]      7 [1.9]                               
      Atrophy                                                       2 [3.0]      3 [3.0]      5 [2.4]                               
      Degeneration, Cystic                            13 [2.1]     14 [2.2]     14 [1.8]     18 [2.0]                               
      Hematopoietic Cell Proliferation                 1 [1.0]                                                                      
      Hyperplasia                                     11 [2.2]     17 [2.5]     25 [2.6]     21 [2.8]                               
      Hypertrophy                                     47 [2.0]     42 [2.2]     41 [2.3]     40 [1.9]                               
      Necrosis                                         1 [3.0]      3 [2.3]                   2 [2.0]                               
      Vacuolization Cytoplasmic                       11 [1.5]     15 [1.5]     10 [1.4]     13 [1.6]                               
   Adrenal Medulla                                    (52)         (49)         (52)         (49)                                   
      Hyperplasia                                     15 [1.8]      8 [1.5]     13 [2.1]      6 [1.5]                               
   Islets, Pancreatic                                 (53)         (49)         (52)         (49)                                   
      Hyperplasia                                                   1 [2.0]                                                         
   Pituitary Gland                                    (53)         (50)         (52)         (51)                                   
      Angiectasis                                     17 [2.4]     14 [2.4]     17 [2.0]      7 [2.0]                               
      Cyst                                             1 [2.0]                                                                      
      Cytoplasmic Alteration                                        1 [2.0]                   2 [2.5]                               
      Inflammation                                                               1 [2.0]                                            
      Necrosis                                                                                1 [2.0]                               
      Vacuolization Cytoplasmic                                                  1 [2.0]      2 [1.5]                               
      Pars Distalis, Hyperplasia                      13 [2.4]     17 [2.2]     20 [2.5]     21 [2.2]                               
a  Number of animals examined microscopically at site and number of animals with lesion                                             
b  Average severity grade (1-minimal;2-mild;3-moderate;4-marked)                                                                    
                                                             Page    4                                                              
NTP Experiment-Test: 96020-01         INCIDENCE RATES OF NONNEOPLASTIC LESIONS BY ANATOMIC SITE (a)               Report: PEIRPT18  
Study Type: CHRONIC                                  WITH AVERAGE SEVERITY GRADES[b]                              Date: 03/03/04    
Route: GAVAGE                                  TEF EVALUATION (BINARY MIXTURE; PCB 126/PCB 153)                   Time: 10:12:20    
____________________________________________________________________________________________________________________________________
         SPRAGUE-DAWLEY RATS FEMALE                   0 NG /       300 NG /     300 NG /     300 NG /                               
                                                      0 UG         100 UG       300 UG       3000 UG                                
____________________________________________________________________________________________________________________________________
ENDOCRINE SYSTEM - CONT                                                                                                             
   Thyroid Gland                                      (53)         (49)         (52)         (50)                                   
      Fibrosis                                                                                1 [2.0]                               
      Inflammation, Chronic                                         1 [3.0]                                                         
      C-Cell, Hyperplasia                             15 [2.1]     16 [1.8]     12 [2.3]     17 [1.8]                               
      Follicle, Cyst                                   2 [2.0]                                                                      
      Follicular Cell, Hyperplasia                                  1 [4.0]                                                         
      Follicular Cell, Hypertrophy                    14 [1.3]     28 [1.6]     35 [1.5]     44 [1.8]                               
____________________________________________________________________________________________________________________________________
 GENERAL BODY SYSTEM                                                                                                                
   None                                                                                                                             
____________________________________________________________________________________________________________________________________
 GENITAL SYSTEM                                                                                                                     
   Clitoral Gland                                     (53)         (49)         (53)         (50)                                   
      Hyperplasia, Squamous                                         1 [2.0]                                                         
      Inflammation                                    45 [1.8]     38 [1.4]     40 [1.4]     40 [1.2]                               
      Duct, Cyst                                      38 [2.1]     41 [2.5]     43 [2.3]     41 [2.3]                               
   Ovary                                              (53)         (48)         (52)         (50)                                   
      Atrophy                                         45 [4.0]     46 [4.0]     43 [4.0]     36 [3.9]                               
      Cyst                                            14 [2.4]     16 [2.0]     14 [2.6]     19 [2.3]                               
      Inflammation, Chronic Active                     1 [2.0]                                4 [2.8]                               
      Inflammation, Granulomatous                                   1 [3.0]                                                         
      Inflammation, Suppurative                                                  1 [2.0]                                            
   Oviduct                                            (1)          (1)          (2)          (3)                                    
      Cyst                                             1 [2.0]                   2 [2.0]                                            
      Inflammation, Chronic Active                                                            3 [3.0]                               
      Metaplasia, Squamous                                          1 [4.0]                                                         
   Uterus                                             (53)         (50)         (52)         (50)                                   
      Adenomyosis                                                   1 [2.0]                                                         
      Hemorrhage                                                    1 [3.0]                                                         
      Inflammation, Chronic Active                     3 [2.3]      4 [2.5]      7 [2.6]      8 [3.0]                               
      Inflammation, Suppurative                        3 [1.3]      2 [2.0]     10 [1.6]      8 [1.5]                               
      Metaplasia, Squamous                            27 [2.0]     27 [2.7]     36 [2.9]     34 [2.8]                               
      Cervix, Cyst                                                  1 [3.0]                                                         
      Endometrium, Hyperplasia, Cystic                28 [2.0]     25 [2.5]     18 [2.2]     15 [2.3]                               
____________________________________________________________________________________________________________________________________
 HEMATOPOIETIC SYSTEM                                                                                                               
   Bone Marrow                                        (53)         (50)         (53)         (51)                                   
a  Number of animals examined microscopically at site and number of animals with lesion                                             
b  Average severity grade (1-minimal;2-mild;3-moderate;4-marked)                                                                    
                                                             Page    5                                                              
NTP Experiment-Test: 96020-01         INCIDENCE RATES OF NONNEOPLASTIC LESIONS BY ANATOMIC SITE (a)               Report: PEIRPT18  
Study Type: CHRONIC                                  WITH AVERAGE SEVERITY GRADES[b]                              Date: 03/03/04    
Route: GAVAGE                                  TEF EVALUATION (BINARY MIXTURE; PCB 126/PCB 153)                   Time: 10:12:20    
____________________________________________________________________________________________________________________________________
         SPRAGUE-DAWLEY RATS FEMALE                   0 NG /       300 NG /     300 NG /     300 NG /                               
                                                      0 UG         100 UG       300 UG       3000 UG                                
____________________________________________________________________________________________________________________________________
HEMATOPOIETIC SYSTEM - CONT                                                                                                         
      Hyperplasia                                     39 [3.2]     38 [2.6]     48 [2.8]     39 [3.1]                               
   Lymph Node                                         (4)          (2)          (7)          (5)                                    
      Angiectasis                                                                1 [2.0]                                            
      Inguinal, Hyperplasia, Plasma Cell                                         1 [2.0]                                            
      Lumbar, Ectasia                                  4 [2.3]                   1 [2.0]      1 [3.0]                               
      Lumbar, Hemorrhage                                                                      1 [2.0]                               
      Lumbar, Hyperplasia, Plasma Cell                 4 [2.3]                                                                      
      Mediastinal, Ectasia                                                                    2 [2.5]                               
      Mediastinal, Hemorrhage                                                    1 [2.0]      2 [2.0]                               
      Mediastinal, Hyperplasia, Histiocytic                                      1 [2.0]      1 [2.0]                               
      Mediastinal, Hyperplasia, Lymphoid                            1 [4.0]                                                         
      Mediastinal, Hyperplasia, Plasma Cell                         1 [2.0]                   1 [2.0]                               
      Pancreatic, Hyperplasia, Histiocytic                                       1 [2.0]                                            
      Pancreatic, Pigmentation                                                   1 [2.0]                                            
      Renal, Ectasia                                                             1 [2.0]                                            
      Renal, Hyperplasia, Histiocytic                                            1 [2.0]                                            
      Renal, Hyperplasia, Plasma Cell                                            1 [2.0]                                            
   Lymph Node, Mandibular                             (53)         (49)         (50)         (49)                                   
      Congestion                                                                 1 [3.0]                                            
      Ectasia                                                                    3 [1.7]      2 [2.0]                               
      Hyperplasia, Lymphoid                            1 [2.0]                   2 [2.0]      2 [3.0]                               
      Hyperplasia, Plasma Cell                        37 [2.2]     33 [2.3]     36 [2.4]     32 [2.4]                               
   Lymph Node, Mesenteric                             (53)         (49)         (52)         (49)                                   
      Hemorrhage                                                                 1 [2.0]                                            
      Hyperplasia, Histiocytic                                                   1 [2.0]                                            
      Hyperplasia, Lymphoid                                         1 [4.0]                                                         
      Hyperplasia, Plasma Cell                                      1 [2.0]                   2 [2.0]                               
   Spleen                                             (53)         (49)         (52)         (49)                                   
      Fibrosis                                                                   1 [3.0]                                            
      Hematopoietic Cell Proliferation                51 [2.2]     41 [2.0]     47 [2.0]     45 [2.0]                               
      Pigmentation                                    47 [1.5]     48 [1.8]     51 [1.7]     49 [1.6]                               
      Lymphoid Follicle, Atrophy                                    5 [2.6]      4 [2.5]      2 [2.5]                               
      Red Pulp, Atrophy                                1 [2.0]      1 [3.0]                   1 [2.0]                               
   Thymus                                             (53)         (48)         (50)         (47)                                   
      Atrophy                                         33 [2.3]     48 [3.5]     42 [3.8]     45 [3.4]                               
      Cyst                                                                       1 [3.0]                                            
      Hemorrhage                                       1 [2.0]                   3 [2.3]                                            
      Hyperplasia, Lymphoid                            2 [2.5]                                                                      
      Epithelial Cell, Hyperplasia                                               1 [2.0]                                            
____________________________________________________________________________________________________________________________________
 INTEGUMENTARY SYSTEM                                                                                                               
a  Number of animals examined microscopically at site and number of animals with lesion                                             
b  Average severity grade (1-minimal;2-mild;3-moderate;4-marked)                                                                    
                                                             Page    6                                                              
NTP Experiment-Test: 96020-01         INCIDENCE RATES OF NONNEOPLASTIC LESIONS BY ANATOMIC SITE (a)               Report: PEIRPT18  
Study Type: CHRONIC                                  WITH AVERAGE SEVERITY GRADES[b]                              Date: 03/03/04    
Route: GAVAGE                                  TEF EVALUATION (BINARY MIXTURE; PCB 126/PCB 153)                   Time: 10:12:20    
____________________________________________________________________________________________________________________________________
         SPRAGUE-DAWLEY RATS FEMALE                   0 NG /       300 NG /     300 NG /     300 NG /                               
                                                      0 UG         100 UG       300 UG       3000 UG                                
____________________________________________________________________________________________________________________________________
INTEGUMENTARY SYSTEM - CONT                                                                                                         
   Mammary Gland                                      (53)         (50)         (53)         (51)                                   
      Cyst                                             3 [3.0]      2 [2.0]      3 [2.3]      2 [2.5]                               
      Hyperplasia                                     29 [1.5]     14 [1.6]     22 [1.4]     15 [1.5]                               
      Inflammation, Granulomatous                      5 [2.0]      2 [2.0]      3 [1.7]                                            
      Duct, Cyst                                       1 [4.0]                                                                      
   Skin                                               (53)         (50)         (53)         (51)                                   
      Angiectasis                                      1 [3.0]                                                                      
      Cyst Epithelial Inclusion                                                  1                                                  
      Edema                                                                                   1 [3.0]                               
      Fibrosis                                         1 [3.0]                                                                      
      Inflammation                                                                            2 [3.0]                               
      Necrosis                                                                                1 [3.0]                               
      Subcutaneous Tissue, Edema                                                              1 [3.0]                               
____________________________________________________________________________________________________________________________________
 MUSCULOSKELETAL SYSTEM                                                                                                             
   Skeletal Muscle                                    (1)          (1)          (1)          (3)                                    
      Inflammation                                                                            1 [3.0]                               
      Necrosis                                                                                1 [3.0]                               
____________________________________________________________________________________________________________________________________
 NERVOUS SYSTEM                                                                                                                     
   Brain                                              (53)         (50)         (52)         (51)                                   
      Hemorrhage                                                    1 [2.0]      1 [3.0]                                            
      Hydrocephalus                                    1 [2.0]      1 [2.0]                   1 [2.0]                               
      Cerebellum, Hemorrhage                                        1 [2.0]                                                         
____________________________________________________________________________________________________________________________________
 RESPIRATORY SYSTEM                                                                                                                 
   Lung                                               (53)         (50)         (53)         (50)                                   
      Hemorrhage                                                    1 [1.0]                                                         
      Infiltration Cellular, Histiocyte               47 [1.8]     49 [1.8]     46 [1.7]     40 [1.4]                               
      Inflammation                                     8 [1.8]      2 [1.5]      4 [1.8]      2 [1.0]                               
      Metaplasia, Squamous                                          3 [2.7]      2 [1.5]      6 [1.7]                               
      Mineralization                                                             1 [2.0]                                            
      Alveolar Epithelium, Hyperplasia                23 [1.2]      5 [1.2]      5 [1.4]      8 [1.3]                               
      Alveolar Epithelium, Metaplasia, Bronchiolar                 39 [1.7]     34 [1.7]     30 [1.8]                               
      Mediastinum, Necrosis                                         1 [2.0]      1 [3.0]                                            
      Serosa, Inflammation                                                       1 [2.0]                                            
   Nose                                               (53)         (50)         (53)         (51)                                   
a  Number of animals examined microscopically at site and number of animals with lesion                                             
b  Average severity grade (1-minimal;2-mild;3-moderate;4-marked)                                                                    
                                                             Page    7                                                              
NTP Experiment-Test: 96020-01         INCIDENCE RATES OF NONNEOPLASTIC LESIONS BY ANATOMIC SITE (a)               Report: PEIRPT18  
Study Type: CHRONIC                                  WITH AVERAGE SEVERITY GRADES[b]                              Date: 03/03/04    
Route: GAVAGE                                  TEF EVALUATION (BINARY MIXTURE; PCB 126/PCB 153)                   Time: 10:12:20    
____________________________________________________________________________________________________________________________________
         SPRAGUE-DAWLEY RATS FEMALE                   0 NG /       300 NG /     300 NG /     300 NG /                               
                                                      0 UG         100 UG       300 UG       3000 UG                                
____________________________________________________________________________________________________________________________________
RESPIRATORY SYSTEM - CONT                                                                                                           
      Hyperplasia                                                                             1 [3.0]                               
      Inflammation                                    22 [1.5]     17 [1.2]     13 [1.6]     15 [1.7]                               
      Nerve, Degeneration                                                                     1 [3.0]                               
      Olfactory Epithelium, Degeneration               1 [2.0]      1 [2.0]                                                         
      Olfactory Epithelium, Dysplasia                                                         1 [3.0]                               
      Olfactory Epithelium, Metaplasia                 4 [2.3]      5 [2.0]      6 [2.2]      5 [2.0]                               
      Respiratory Epithelium, Hyperplasia             10 [2.4]     14 [2.1]     11 [2.1]     12 [2.3]                               
      Respiratory Epithelium, Metaplasia               1 [2.0]                                                                      
   Trachea                                            (53)         (50)         (53)         (50)                                   
      Inflammation                                     1 [1.0]                                                                      
      Peritracheal Tissue, Inflammation                                                       1 [3.0]                               
____________________________________________________________________________________________________________________________________
 SPECIAL SENSES SYSTEM                                                                                                              
   Eye                                                (53)         (50)         (52)         (51)                                   
      Anterior Chamber, Ciliary Body, Cornea,                                                                                       
        Inflammation                                                2 [3.0]      1 [3.0]                                            
      Cornea, Inflammation                                          1 [1.0]      1 [3.0]                                            
      Retina, Atrophy                                  1 [2.0]                   2 [2.0]      5 [2.0]                               
   Harderian Gland                                    (53)         (49)         (52)         (51)                                   
      Inflammation                                    20 [1.0]     15 [1.2]     14 [1.3]     17 [1.1]                               
____________________________________________________________________________________________________________________________________
 URINARY SYSTEM                                                                                                                     
   Kidney                                             (53)         (48)         (52)         (51)                                   
      Accumulation, Hyaline Droplet                    2 [2.0]                   1 [2.0]      2 [1.5]                               
      Calculus Micro Observation Only                  7            6            4            6                                     
      Casts Protein                                    2 [2.0]                                                                      
      Cyst                                                          1 [2.0]      1 [3.0]                                            
      Hydronephrosis                                                                          2 [3.0]                               
      Infarct                                                                                 2 [2.5]                               
      Inflammation, Chronic Active                     1 [2.0]                   1 [3.0]      1 [1.0]                               
      Inflammation, Suppurative                        5 [1.2]      6 [1.8]      5 [1.0]      3 [1.0]                               
      Mineralization                                  42 [1.0]     39 [1.1]     42 [1.0]     33 [1.0]                               
      Nephropathy                                     29 [1.2]     30 [1.2]     34 [1.3]     34 [1.5]                               
      Pigmentation                                                  2 [1.5]      7 [1.3]     17 [1.5]                               
      Pelvis, Dilatation                               1 [2.0]      4 [2.0]      2 [2.5]                                            
      Pelvis, Inflammation                             3 [2.0]      1 [2.0]      3 [2.3]      8 [2.3]                               
      Renal Tubule, Degeneration                                                 2 [2.0]                                            
      Renal Tubule, Hyperplasia                                                               1 [2.0]                               
      Transitional Epithelium, Hyperplasia             2 [2.0]      6 [2.2]     11 [1.9]      9 [2.8]                               
a  Number of animals examined microscopically at site and number of animals with lesion                                             
b  Average severity grade (1-minimal;2-mild;3-moderate;4-marked)                                                                    
                                                             Page    8                                                              
NTP Experiment-Test: 96020-01         INCIDENCE RATES OF NONNEOPLASTIC LESIONS BY ANATOMIC SITE (a)               Report: PEIRPT18  
Study Type: CHRONIC                                  WITH AVERAGE SEVERITY GRADES[b]                              Date: 03/03/04    
Route: GAVAGE                                  TEF EVALUATION (BINARY MIXTURE; PCB 126/PCB 153)                   Time: 10:12:20    
____________________________________________________________________________________________________________________________________
         SPRAGUE-DAWLEY RATS FEMALE                   0 NG /       300 NG /     300 NG /     300 NG /                               
                                                      0 UG         100 UG       300 UG       3000 UG                                
____________________________________________________________________________________________________________________________________
URINARY SYSTEM - CONT                                                                                                               
   Ureter                                             (1)                       (1)          (1)                                    
      Inflammation                                     1 [2.0]                   1 [2.0]      1 [2.0]                               
      Transitional Epithelium, Hyperplasia             1 [3.0]                                1 [3.0]                               
   Urinary Bladder                                    (53)         (49)         (52)         (50)                                   
      Inflammation                                     7 [1.1]      3 [1.0]      7 [1.4]      8 [1.4]                               
      Transitional Epithelium, Hyperplasia                                       1 [2.0]      1 [2.0]                               
a  Number of animals examined microscopically at site and number of animals with lesion                                             
b  Average severity grade (1-minimal;2-mild;3-moderate;4-marked)                                                                    
                                                             Page    9                                                              
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