TDMS Study 60855-01 Pathology Tables
NTP Experiment-Test: 60855-01 INCIDENCE RATES OF NONNEOPLASTIC LESIONS BY ANATOMIC SITE (a) Report: PEIRPT03
Study Type: 18-33 DAYS BETA-BROMO-BETA-NITROSTYRENE Date: 10/19/04
Route: GAVAGE Time: 14:10:50
Facility: BIORELIANCE
Chemical CAS #: 7166-19-0
Lock Date: 04/23/92
Cage Range: All
Reasons For Removal: All
Removal Date Range: All
Treatment Groups: Include All
a Number of animals examined microscopically at site and number of animals with lesion
Page 1
NTP Experiment-Test: 60855-01 INCIDENCE RATES OF NONNEOPLASTIC LESIONS BY ANATOMIC SITE (a) Report: PEIRPT03
Study Type: 18-33 DAYS BETA-BROMO-BETA-NITROSTYRENE Date: 10/19/04
Route: GAVAGE Time: 14:10:50
____________________________________________________________________________________________________________________________________
FISCHER 344 RATS FEMALE CONTROL CONTROL 0.037 0.037 0.075 0.075
G/KG G/KG G/KG
____________________________________________________________________________________________________________________________________
DISPOSITION SUMMARY
Animals Initially In Study 10 10 10 10 10 10
Scheduled Sacrifice 10 10 10
Early Deaths
Survivors
Terminal Sacrifice 10 10 10
Animals Examined Microscopically 10 10 10
____________________________________________________________________________________________________________________________________
ALIMENTARY SYSTEM
Liver (10) (1) (3)
Hepatodiaphragmatic Nodule 1 (100%) 3 (100%)
____________________________________________________________________________________________________________________________________
CARDIOVASCULAR SYSTEM
Heart (10)
Inflammation 1 (10%)
____________________________________________________________________________________________________________________________________
ENDOCRINE SYSTEM
None
____________________________________________________________________________________________________________________________________
GENERAL BODY SYSTEM
None
____________________________________________________________________________________________________________________________________
GENITAL SYSTEM
Clitoral Gland (10)
Inflammation 3 (30%)
Uterus (10) (1)
Bilateral, Hydrometra 2 (20%) 1 (100%)
____________________________________________________________________________________________________________________________________
HEMATOPOIETIC SYSTEM
a Number of animals examined microscopically at site and number of animals with lesion
Page 2
NTP Experiment-Test: 60855-01 INCIDENCE RATES OF NONNEOPLASTIC LESIONS BY ANATOMIC SITE (a) Report: PEIRPT03
Study Type: 18-33 DAYS BETA-BROMO-BETA-NITROSTYRENE Date: 10/19/04
Route: GAVAGE Time: 14:10:50
____________________________________________________________________________________________________________________________________
FISCHER 344 RATS FEMALE CONTROL CONTROL 0.037 0.037 0.075 0.075
G/KG G/KG G/KG
____________________________________________________________________________________________________________________________________
None
____________________________________________________________________________________________________________________________________
INTEGUMENTARY SYSTEM
None
____________________________________________________________________________________________________________________________________
MUSCULOSKELETAL SYSTEM
None
____________________________________________________________________________________________________________________________________
NERVOUS SYSTEM
None
____________________________________________________________________________________________________________________________________
RESPIRATORY SYSTEM
Nose (10) (10) (10)
Foreign Body 1 (10%)
Inflammation 1 (10%) 3 (30%) 4 (40%)
Olfactory Epithelium, Degeneration 3 (30%)
Olfactory Epithelium, Metaplasia 1 (10%)
Respiratory Epithelium, Degeneration 1 (10%) 1 (10%)
Respiratory Epithelium, Metaplasia, Squamous 1 (10%)
Respiratory Epithelium, Necrosis 1 (10%)
____________________________________________________________________________________________________________________________________
SPECIAL SENSES SYSTEM
None
____________________________________________________________________________________________________________________________________
URINARY SYSTEM
Kidney (10)
Mineralization 4 (40%)
a Number of animals examined microscopically at site and number of animals with lesion
Page 3
NTP Experiment-Test: 60855-01 INCIDENCE RATES OF NONNEOPLASTIC LESIONS BY ANATOMIC SITE (a) Report: PEIRPT03
Study Type: 18-33 DAYS BETA-BROMO-BETA-NITROSTYRENE Date: 10/19/04
Route: GAVAGE Time: 14:10:50
____________________________________________________________________________________________________________________________________
FISCHER 344 RATS FEMALE 0.150 0.150 0.300 0.300 0.600 0.600
G/KG G/KG G/KG G/KG G/KG G/KG
____________________________________________________________________________________________________________________________________
DISPOSITION SUMMARY
Animals Initially In Study 10 10 10 10 10 10
Scheduled Sacrifice 10 10
Early Deaths
Moribund Sacrifice 1 7 6
Natural Death 3 4
Survivors
Terminal Sacrifice 10 9
Animals Examined Microscopically 10 10 10
____________________________________________________________________________________________________________________________________
ALIMENTARY SYSTEM
Intestine Large, Cecum (10) (10) (10)
Inflammation 8 (80%) 1 (10%)
Liver (1) (10) (10)
Congestion 1 (10%)
Cytoplasmic Alteration 1 (10%)
Hepatodiaphragmatic Nodule 1 (100%)
Inflammation 2 (20%)
Necrosis, Focal 2 (20%)
Centrilobular, Vacuolization Cytoplasmic 1 (10%)
Pancreas (10) (10)
Inflammation 3 (30%)
Stomach, Forestomach (10) (10) (10)
Hemorrhage 4 (40%)
Inflammation 7 (70%) 9 (90%)
Necrosis 8 (80%)
Ulcer 3 (30%)
Epithelium, Hyperkeratosis 10 (100%) 8 (80%)
Epithelium, Hyperplasia 8 (80%) 10 (100%)
Stomach, Glandular (10) (10) (10)
Inflammation 6 (60%)
____________________________________________________________________________________________________________________________________
CARDIOVASCULAR SYSTEM
Heart (10) (10)
Hemorrhage 1 (10%)
Inflammation 1 (10%)
____________________________________________________________________________________________________________________________________
a Number of animals examined microscopically at site and number of animals with lesion
Page 4
NTP Experiment-Test: 60855-01 INCIDENCE RATES OF NONNEOPLASTIC LESIONS BY ANATOMIC SITE (a) Report: PEIRPT03
Study Type: 18-33 DAYS BETA-BROMO-BETA-NITROSTYRENE Date: 10/19/04
Route: GAVAGE Time: 14:10:50
____________________________________________________________________________________________________________________________________
FISCHER 344 RATS FEMALE 0.150 0.150 0.300 0.300 0.600 0.600
G/KG G/KG G/KG G/KG G/KG G/KG
____________________________________________________________________________________________________________________________________
ENDOCRINE SYSTEM
Adrenal Medulla (10) (7)
Degeneration 1 (10%)
____________________________________________________________________________________________________________________________________
GENERAL BODY SYSTEM
None
____________________________________________________________________________________________________________________________________
GENITAL SYSTEM
Clitoral Gland (10) (10)
Inflammation 5 (50%) 1 (10%)
____________________________________________________________________________________________________________________________________
HEMATOPOIETIC SYSTEM
Bone Marrow (10) (10)
Depletion Cellular 1 (10%)
Hemorrhage 1 (10%) 1 (10%)
Myeloid Cell, Hyperplasia 1 (10%)
Lymph Node, Mandibular (9) (10)
Hemorrhage 2 (22%)
Hyperplasia, Lymphoid 1 (11%)
Lymph Node, Mesenteric (10) (10)
Atrophy 1 (10%)
Hemorrhage 1 (10%) 7 (70%)
Spleen (10) (10)
Atrophy 1 (10%)
Inflammation 2 (20%)
Thymus (10) (10)
Atrophy 1 (10%) 2 (20%)
Hemorrhage 2 (20%)
Necrosis 1 (10%) 1 (10%)
____________________________________________________________________________________________________________________________________
INTEGUMENTARY SYSTEM
None
____________________________________________________________________________________________________________________________________
a Number of animals examined microscopically at site and number of animals with lesion
Page 5
NTP Experiment-Test: 60855-01 INCIDENCE RATES OF NONNEOPLASTIC LESIONS BY ANATOMIC SITE (a) Report: PEIRPT03
Study Type: 18-33 DAYS BETA-BROMO-BETA-NITROSTYRENE Date: 10/19/04
Route: GAVAGE Time: 14:10:50
____________________________________________________________________________________________________________________________________
FISCHER 344 RATS FEMALE 0.150 0.150 0.300 0.300 0.600 0.600
G/KG G/KG G/KG G/KG G/KG G/KG
____________________________________________________________________________________________________________________________________
MUSCULOSKELETAL SYSTEM
Skeletal Muscle (1)
Atrophy, Focal 1 (100%)
____________________________________________________________________________________________________________________________________
NERVOUS SYSTEM
None
____________________________________________________________________________________________________________________________________
RESPIRATORY SYSTEM
Lung (10) (10)
Congestion 3 (30%)
Hemorrhage 2 (20%) 1 (10%)
Inflammation 1 (10%)
Nose (10) (10) (10)
Inflammation 6 (60%) 3 (30%) 1 (10%)
Necrosis 2 (20%)
Olfactory Epithelium, Degeneration 2 (20%)
Olfactory Epithelium, Metaplasia 1 (10%)
Olfactory Epithelium, Necrosis 1 (10%)
Respiratory Epithelium, Degeneration 1 (10%) 1 (10%)
Respiratory Epithelium, Metaplasia, Squamous 4 (40%) 2 (20%)
____________________________________________________________________________________________________________________________________
SPECIAL SENSES SYSTEM
None
____________________________________________________________________________________________________________________________________
URINARY SYSTEM
Kidney (10) (10)
Mineralization 5 (50%) 7 (70%)
a Number of animals examined microscopically at site and number of animals with lesion
Page 6
NTP Experiment-Test: 60855-01 INCIDENCE RATES OF NONNEOPLASTIC LESIONS BY ANATOMIC SITE (a) Report: PEIRPT03
Study Type: 18-33 DAYS BETA-BROMO-BETA-NITROSTYRENE Date: 10/19/04
Route: GAVAGE Time: 14:10:50
____________________________________________________________________________________________________________________________________
FISCHER 344 RATS MALE CONTROL CONTROL 0.037 0.037 0.075 0.075
G/KG G/KG G/KG G/KG
____________________________________________________________________________________________________________________________________
DISPOSITION SUMMARY
Animals Initially In Study 10 10 10 10 10 10
Scheduled Sacrifice 10 10 10
Early Deaths
Survivors
Terminal Sacrifice 10 10 10
Animals Examined Microscopically 10 10 10
____________________________________________________________________________________________________________________________________
ALIMENTARY SYSTEM
Intestine Large, Cecum (10) (10) (10)
Inflammation 1 (10%) 4 (40%)
Liver (10) (1)
Hepatodiaphragmatic Nodule 1 (100%)
Stomach, Forestomach (10) (10) (10)
Epithelium, Hyperkeratosis 4 (40%)
Epithelium, Hyperplasia 3 (30%)
____________________________________________________________________________________________________________________________________
CARDIOVASCULAR SYSTEM
Heart (10)
Inflammation 3 (30%)
____________________________________________________________________________________________________________________________________
ENDOCRINE SYSTEM
None
____________________________________________________________________________________________________________________________________
GENERAL BODY SYSTEM
None
____________________________________________________________________________________________________________________________________
GENITAL SYSTEM
Preputial Gland (10)
Inflammation 2 (20%)
____________________________________________________________________________________________________________________________________
a Number of animals examined microscopically at site and number of animals with lesion
Page 7
NTP Experiment-Test: 60855-01 INCIDENCE RATES OF NONNEOPLASTIC LESIONS BY ANATOMIC SITE (a) Report: PEIRPT03
Study Type: 18-33 DAYS BETA-BROMO-BETA-NITROSTYRENE Date: 10/19/04
Route: GAVAGE Time: 14:10:50
____________________________________________________________________________________________________________________________________
FISCHER 344 RATS MALE CONTROL CONTROL 0.037 0.037 0.075 0.075
G/KG G/KG G/KG G/KG
____________________________________________________________________________________________________________________________________
HEMATOPOIETIC SYSTEM
Thymus (10)
Hemorrhage 2 (20%)
____________________________________________________________________________________________________________________________________
INTEGUMENTARY SYSTEM
None
____________________________________________________________________________________________________________________________________
MUSCULOSKELETAL SYSTEM
None
____________________________________________________________________________________________________________________________________
NERVOUS SYSTEM
None
____________________________________________________________________________________________________________________________________
RESPIRATORY SYSTEM
Lung (10)
Hemorrhage 3 (30%)
Inflammation, Focal 3 (30%)
Nose (10) (10) (10)
Inflammation 2 (20%) 1 (10%) 2 (20%)
Olfactory Epithelium, Degeneration 2 (20%)
Respiratory Epithelium, Metaplasia, Squamous 1 (10%) 1 (10%)
____________________________________________________________________________________________________________________________________
SPECIAL SENSES SYSTEM
None
____________________________________________________________________________________________________________________________________
URINARY SYSTEM
None
a Number of animals examined microscopically at site and number of animals with lesion
Page 8
NTP Experiment-Test: 60855-01 INCIDENCE RATES OF NONNEOPLASTIC LESIONS BY ANATOMIC SITE (a) Report: PEIRPT03
Study Type: 18-33 DAYS BETA-BROMO-BETA-NITROSTYRENE Date: 10/19/04
Route: GAVAGE Time: 14:10:50
____________________________________________________________________________________________________________________________________
FISCHER 344 RATS MALE 0.150 0.150 0.300 0.300 0.600 0.600
G/KG G/KG G/KG G/KG G/KG
____________________________________________________________________________________________________________________________________
DISPOSITION SUMMARY
Animals Initially In Study 10 10 10 10 10 10
Scheduled Sacrifice 10 8
Early Deaths
Moribund Sacrifice 2 4 2
Natural Death 1 2 6 8
Survivors
Terminal Sacrifice 8 9
Animals Examined Microscopically 10 10 10
____________________________________________________________________________________________________________________________________
ALIMENTARY SYSTEM
Intestine Large, Colon (2) (10) (9)
Inflammation 1 (50%)
Intestine Large, Cecum (10) (10) (8)
Inflammation 6 (60%) 9 (90%) 2 (25%)
Intestine Small, Jejunum (2) (10) (7)
Inflammation 1 (50%)
Intestine Small, Ileum (2) (10) (9)
Inflammation 1 (50%)
Liver (2) (10) (10)
Congestion 1 (10%)
Inflammation 1 (10%)
Centrilobular, Necrosis 1 (10%)
Centrilobular, Vacuolization Cytoplasmic 1 (10%)
Pancreas (2) (10) (10)
Inflammation 1 (10%)
Stomach, Forestomach (10) (10) (10)
Foreign Body 1 (10%)
Hemorrhage 6 (60%)
Inflammation 4 (40%) 9 (90%)
Necrosis 1 (10%) 3 (30%)
Ulcer 3 (30%)
Epithelium, Hyperkeratosis 9 (90%) 9 (90%)
Epithelium, Hyperplasia 7 (70%) 10 (100%)
Stomach, Glandular (10) (10) (10)
Congestion 1 (10%)
Hemorrhage 1 (10%)
Inflammation 4 (40%)
____________________________________________________________________________________________________________________________________
a Number of animals examined microscopically at site and number of animals with lesion
Page 9
NTP Experiment-Test: 60855-01 INCIDENCE RATES OF NONNEOPLASTIC LESIONS BY ANATOMIC SITE (a) Report: PEIRPT03
Study Type: 18-33 DAYS BETA-BROMO-BETA-NITROSTYRENE Date: 10/19/04
Route: GAVAGE Time: 14:10:50
____________________________________________________________________________________________________________________________________
FISCHER 344 RATS MALE 0.150 0.150 0.300 0.300 0.600 0.600
G/KG G/KG G/KG G/KG G/KG
____________________________________________________________________________________________________________________________________
CARDIOVASCULAR SYSTEM
Heart (2) (10) (10)
Inflammation 1 (10%)
____________________________________________________________________________________________________________________________________
ENDOCRINE SYSTEM
None
____________________________________________________________________________________________________________________________________
GENERAL BODY SYSTEM
None
____________________________________________________________________________________________________________________________________
GENITAL SYSTEM
Preputial Gland (2) (10) (10)
Inflammation 1 (10%) 4 (40%)
Prostate (2) (10) (10)
Inflammation 2 (20%)
Testes (10) (10) (10)
Degeneration 2 (20%) 1 (10%) 9 (90%)
____________________________________________________________________________________________________________________________________
HEMATOPOIETIC SYSTEM
Bone Marrow (2) (10) (10)
Depletion Cellular 1 (10%) 1 (10%)
Hyperplasia 1 (10%)
Myeloid Cell, Depletion Cellular 1 (10%)
Myeloid Cell, Hyperplasia 1 (10%)
Lymph Node, Mandibular (2) (10) (9)
Hemorrhage 1 (50%) 1 (10%)
Hyperplasia, Lymphoid 2 (20%)
Hyperplasia, Plasma Cell 1 (50%)
Lymph Node, Mesenteric (2) (10) (10)
Hemorrhage 2 (20%) 4 (40%)
Spleen (2) (10) (10)
Atrophy 1 (50%)
Congestion 1 (10%)
Lymphoid Follicle, Depletion Cellular 2 (20%)
a Number of animals examined microscopically at site and number of animals with lesion
Page 10
NTP Experiment-Test: 60855-01 INCIDENCE RATES OF NONNEOPLASTIC LESIONS BY ANATOMIC SITE (a) Report: PEIRPT03
Study Type: 18-33 DAYS BETA-BROMO-BETA-NITROSTYRENE Date: 10/19/04
Route: GAVAGE Time: 14:10:50
____________________________________________________________________________________________________________________________________
FISCHER 344 RATS MALE 0.150 0.150 0.300 0.300 0.600 0.600
G/KG G/KG G/KG G/KG G/KG
____________________________________________________________________________________________________________________________________
HEMATOPOIETIC SYSTEM - CONT
Thymus (3) (10) (10)
Atrophy 1 (33%) 4 (40%)
Hemorrhage 3 (30%) 5 (50%)
Necrosis 1 (10%)
____________________________________________________________________________________________________________________________________
INTEGUMENTARY SYSTEM
None
____________________________________________________________________________________________________________________________________
MUSCULOSKELETAL SYSTEM
None
____________________________________________________________________________________________________________________________________
NERVOUS SYSTEM
Brain (2) (10) (10)
Congestion 1 (10%)
____________________________________________________________________________________________________________________________________
RESPIRATORY SYSTEM
Lung (2) (10) (10)
Congestion 4 (40%)
Hemorrhage 2 (20%) 3 (30%)
Inflammation 1 (10%)
Nose (10) (10) (10)
Congestion 2 (20%)
Hemorrhage 1 (10%)
Inflammation 6 (60%) 2 (20%) 4 (40%)
Necrosis 1 (10%) 2 (20%)
Olfactory Epithelium, Degeneration 2 (20%) 1 (10%)
Respiratory Epithelium, Degeneration 1 (10%)
Respiratory Epithelium, Metaplasia, Squamous 1 (10%)
____________________________________________________________________________________________________________________________________
SPECIAL SENSES SYSTEM
None
____________________________________________________________________________________________________________________________________
a Number of animals examined microscopically at site and number of animals with lesion
Page 11
NTP Experiment-Test: 60855-01 INCIDENCE RATES OF NONNEOPLASTIC LESIONS BY ANATOMIC SITE (a) Report: PEIRPT03
Study Type: 18-33 DAYS BETA-BROMO-BETA-NITROSTYRENE Date: 10/19/04
Route: GAVAGE Time: 14:10:50
____________________________________________________________________________________________________________________________________
FISCHER 344 RATS MALE 0.150 0.150 0.300 0.300 0.600 0.600
G/KG G/KG G/KG G/KG G/KG
____________________________________________________________________________________________________________________________________
URINARY SYSTEM
None
a Number of animals examined microscopically at site and number of animals with lesion
Page 12
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