TDMS Study 88138-01 Pathology Tables
NTP Experiment-Test: 88138-01 INCIDENCE RATES OF NONNEOPLASTIC LESIONS BY ANATOMIC SITE (a) Report: PEIRPT03
Study Type: SUBCHRON 90-DAY BENZOPHENONE Date: 10/25/04
Route: DOSED FEED Time: 13:28:04
Facility: Battelle Columbus Laboratory
Chemical CAS #: 119-61-9
Lock Date: 08/17/93
Cage Range: All
Reasons For Removal: All
Removal Date Range: All
Treatment Groups: Include All
a Number of animals examined microscopically at site and number of animals with lesion
Page 1
NTP Experiment-Test: 88138-01 INCIDENCE RATES OF NONNEOPLASTIC LESIONS BY ANATOMIC SITE (a) Report: PEIRPT03
Study Type: SUBCHRON 90-DAY BENZOPHENONE Date: 10/25/04
Route: DOSED FEED Time: 13:28:04
____________________________________________________________________________________________________________________________________
FISCHER 344 RATS FEMALE 0% 0.125% 0.25% 0.5% 1.0% 2.0%
____________________________________________________________________________________________________________________________________
DISPOSITION SUMMARY
Animals Initially In Study 10 10 10 10 10 10
Early Deaths
Moribund Sacrifice 9
Natural Death 1
Survivors
Terminal Sacrifice 10 10 10 10 10
Animals Examined Microscopically 10 10 10 10 10 10
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ALIMENTARY SYSTEM
Intestine Large, Cecum (9) (10) (9)
Inflammation, Chronic Active 1 (11%)
Liver (10) (10) (10) (10) (10) (9)
Hepatodiaphragmatic Nodule 1 (10%) 4 (40%) 2 (20%) 3 (30%) 1 (10%) 2 (22%)
Inflammation, Chronic Active 3 (30%)
Inflammation, Granulomatous 2 (20%) 4 (40%)
Hepatocyte, Hypertrophy 2 (20%) 8 (80%) 10 (100%) 10 (100%) 7 (78%)
Hepatocyte, Vacuolization Cytoplasmic 9 (90%) 10 (100%) 7 (78%)
Mesentery (1) (1) (1)
Inflammation, Granulomatous 1 (100%)
Necrosis 1 (100%)
Fat, Inflammation, Chronic Active 1 (100%)
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CARDIOVASCULAR SYSTEM
Heart (10) (10) (9)
Myocardium, Inflammation, Chronic Active 1 (10%) 1 (11%)
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ENDOCRINE SYSTEM
Adrenal Cortex (10) (10) (9)
Accessory Adrenal Cortical Nodule 1 (10%)
Inflammation 1 (10%)
Thyroid Gland (10) (10) (9)
Ultimobranchial Cyst 2 (20%)
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GENERAL BODY SYSTEM
a Number of animals examined microscopically at site and number of animals with lesion
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NTP Experiment-Test: 88138-01 INCIDENCE RATES OF NONNEOPLASTIC LESIONS BY ANATOMIC SITE (a) Report: PEIRPT03
Study Type: SUBCHRON 90-DAY BENZOPHENONE Date: 10/25/04
Route: DOSED FEED Time: 13:28:04
____________________________________________________________________________________________________________________________________
FISCHER 344 RATS FEMALE 0% 0.125% 0.25% 0.5% 1.0% 2.0%
____________________________________________________________________________________________________________________________________
None
____________________________________________________________________________________________________________________________________
GENITAL SYSTEM
Clitoral Gland (10) (10) (9)
Inflammation, Chronic Active 4 (40%) 4 (40%)
Ovary (10) (2) (1) (10) (9)
Periovarian Tissue, Cyst 3 (30%) 2 (100%) 1 (100%)
Periovarian Tissue, Inflammation, Chronic
Active 1 (11%)
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HEMATOPOIETIC SYSTEM
Bone Marrow (10) (10) (10) (10) (10) (10)
Atrophy 2 (20%) 10 (100%)
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INTEGUMENTARY SYSTEM
None
____________________________________________________________________________________________________________________________________
MUSCULOSKELETAL SYSTEM
None
____________________________________________________________________________________________________________________________________
NERVOUS SYSTEM
None
____________________________________________________________________________________________________________________________________
RESPIRATORY SYSTEM
Lung (10) (1) (5) (10) (9)
Inflammation, Chronic Active 1 (100%) 5 (100%) 3 (30%) 6 (67%)
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SPECIAL SENSES SYSTEM
None
a Number of animals examined microscopically at site and number of animals with lesion
Page 3
NTP Experiment-Test: 88138-01 INCIDENCE RATES OF NONNEOPLASTIC LESIONS BY ANATOMIC SITE (a) Report: PEIRPT03
Study Type: SUBCHRON 90-DAY BENZOPHENONE Date: 10/25/04
Route: DOSED FEED Time: 13:28:04
____________________________________________________________________________________________________________________________________
FISCHER 344 RATS FEMALE 0% 0.125% 0.25% 0.5% 1.0% 2.0%
____________________________________________________________________________________________________________________________________
URINARY SYSTEM
Kidney (10) (10) (10) (10) (10) (9)
Inflammation, Chronic Active 2 (20%) 2 (20%)
Mineralization 10 (100%) 10 (100%) 10 (100%) 10 (100%) 10 (100%) 9 (100%)
Papilla, Necrosis 3 (33%)
Pelvis, Inflammation, Suppurative 1 (10%)
Renal Tubule, Casts Protein 2 (20%) 4 (40%)
Renal Tubule, Dilatation 3 (30%) 5 (56%)
Renal Tubule, Regeneration 3 (30%) 8 (80%) 6 (60%) 6 (60%) 9 (90%) 7 (78%)
Urinary Bladder (10) (10) (9)
Transitional Epithelium, Hyperplasia 1 (10%)
a Number of animals examined microscopically at site and number of animals with lesion
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NTP Experiment-Test: 88138-01 INCIDENCE RATES OF NONNEOPLASTIC LESIONS BY ANATOMIC SITE (a) Report: PEIRPT03
Study Type: SUBCHRON 90-DAY BENZOPHENONE Date: 10/25/04
Route: DOSED FEED Time: 13:28:04
____________________________________________________________________________________________________________________________________
FISCHER 344 RATS MALE 0% 0.125% 0.25% 0.5% 1.0% 2.0%
____________________________________________________________________________________________________________________________________
DISPOSITION SUMMARY
Animals Initially In Study 10 10 10 10 10 10
Early Deaths
Moribund Sacrifice 10
Survivors
Terminal Sacrifice 10 10 10 10 10
Animals Examined Microscopically 10 10 10 10 10 10
____________________________________________________________________________________________________________________________________
ALIMENTARY SYSTEM
Esophagus (10) (10) (10)
Epithelium, Hyperkeratosis 1 (10%)
Liver (10) (10) (10) (10) (10) (10)
Cyst 1 (10%)
Hematopoietic Cell Proliferation 1 (10%)
Hepatodiaphragmatic Nodule 1 (10%) 2 (20%) 3 (30%) 2 (20%) 1 (10%) 1 (10%)
Inflammation, Chronic Active 1 (10%)
Necrosis 1 (10%)
Bile Duct, Hyperplasia 9 (90%)
Bile Duct, Inflammation, Chronic Active 1 (10%)
Hepatocyte, Hypertrophy 5 (50%) 7 (70%)
Hepatocyte, Vacuolization Cytoplasmic 1 (10%) 10 (100%) 10 (100%) 10 (100%) 10 (100%) 10 (100%)
Stomach, Glandular (10) (10) (10)
Epithelium, Erosion 1 (10%)
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CARDIOVASCULAR SYSTEM
Heart (10) (10) (10)
Myocardium, Inflammation, Chronic Active 6 (60%) 3 (30%)
____________________________________________________________________________________________________________________________________
ENDOCRINE SYSTEM
Adrenal Cortex (10) (3) (10) (10)
Accessory Adrenal Cortical Nodule 1 (10%)
____________________________________________________________________________________________________________________________________
GENERAL BODY SYSTEM
None
a Number of animals examined microscopically at site and number of animals with lesion
Page 5
NTP Experiment-Test: 88138-01 INCIDENCE RATES OF NONNEOPLASTIC LESIONS BY ANATOMIC SITE (a) Report: PEIRPT03
Study Type: SUBCHRON 90-DAY BENZOPHENONE Date: 10/25/04
Route: DOSED FEED Time: 13:28:04
____________________________________________________________________________________________________________________________________
FISCHER 344 RATS MALE 0% 0.125% 0.25% 0.5% 1.0% 2.0%
____________________________________________________________________________________________________________________________________
GENITAL SYSTEM
Preputial Gland (10) (10) (10)
Inflammation, Chronic Active 2 (20%) 6 (60%) 4 (40%)
Inflammation, Granulomatous 1 (10%)
Prostate (10) (10) (9)
Inflammation, Chronic Active 1 (10%) 1 (11%)
Seminal Vesicle (10) (10) (9)
Atrophy 3 (33%)
Testes (10) (10) (10) (10) (10) (10)
Mineralization 1 (10%)
Germinal Epithelium, Degeneration 10 (100%)
____________________________________________________________________________________________________________________________________
HEMATOPOIETIC SYSTEM
Bone Marrow (10) (10) (10) (10) (10) (10)
Atrophy 10 (100%)
____________________________________________________________________________________________________________________________________
INTEGUMENTARY SYSTEM
None
____________________________________________________________________________________________________________________________________
MUSCULOSKELETAL SYSTEM
None
____________________________________________________________________________________________________________________________________
NERVOUS SYSTEM
None
____________________________________________________________________________________________________________________________________
RESPIRATORY SYSTEM
Lung (10) (2) (3) (10) (10)
Inflammation, Chronic Active 1 (10%) 2 (100%) 3 (100%) 1 (10%) 5 (50%)
____________________________________________________________________________________________________________________________________
SPECIAL SENSES SYSTEM
a Number of animals examined microscopically at site and number of animals with lesion
Page 6
NTP Experiment-Test: 88138-01 INCIDENCE RATES OF NONNEOPLASTIC LESIONS BY ANATOMIC SITE (a) Report: PEIRPT03
Study Type: SUBCHRON 90-DAY BENZOPHENONE Date: 10/25/04
Route: DOSED FEED Time: 13:28:04
____________________________________________________________________________________________________________________________________
FISCHER 344 RATS MALE 0% 0.125% 0.25% 0.5% 1.0% 2.0%
____________________________________________________________________________________________________________________________________
None
____________________________________________________________________________________________________________________________________
URINARY SYSTEM
Kidney (10) (10) (10) (10) (10) (10)
Inflammation, Chronic Active 2 (20%) 3 (30%) 4 (40%) 2 (20%)
Mineralization 5 (50%) 10 (100%)
Papilla, Necrosis 2 (20%) 6 (60%)
Renal Tubule, Accumulation, Hyaline Droplet 1 (10%)
Renal Tubule, Casts Protein 8 (80%) 8 (80%) 9 (90%) 10 (100%)
Renal Tubule, Dilatation 6 (60%) 8 (80%) 9 (90%) 8 (80%)
Renal Tubule, Regeneration 10 (100%) 10 (100%) 10 (100%) 10 (100%) 10 (100%) 8 (80%)
Renal Tubule, Vacuolization Cytoplasmic 1 (10%)
Ureter (2)
Transitional Epithelium, Necrosis 2 (100%)
Urinary Bladder (10) (10) (9)
Transitional Epithelium, Hyperplasia 1 (10%)
a Number of animals examined microscopically at site and number of animals with lesion
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