TDMS Study 61529-01 Pathology Tables
NTP Experiment-Test: 61529-01 INCIDENCE RATES OF NONNEOPLASTIC LESIONS BY ANATOMIC SITE (a) Report: PEIRPT03
Study Type: SUBCHRON 90-DAY M-CHLOROANILINE Date: 10/20/04
Route: GAVAGE Time: 08:51:52
Facility: Battelle Columbus Laboratory
Chemical CAS #: 108-42-09
Lock Date: 11/16/92
Cage Range: All
Reasons For Removal: All
Removal Date Range: All
Treatment Groups: Include 002 0 MG/KG
Include 001 0 MG/KG
Include 004 10 MG/KG
Include 003 10 MG/KG
Include 006 20 MG/KG
Include 005 20 MG/KG
Include 008 40 MG/KG
Include 007 40 MG/KG
Include 010 80 MG/KG
Include 009 80 MG/KG
Include 012 160 MG/KG
Include 011 160 MG/KG
a Number of animals examined microscopically at site and number of animals with lesion
Page 1
NTP Experiment-Test: 61529-01 INCIDENCE RATES OF NONNEOPLASTIC LESIONS BY ANATOMIC SITE (a) Report: PEIRPT03
Study Type: SUBCHRON 90-DAY M-CHLOROANILINE Date: 10/20/04
Route: GAVAGE Time: 08:51:52
____________________________________________________________________________________________________________________________________
FISCHER 344 RATS FEMALE 0 MG/KG 10 MG/KG 20 MG/KG 40 MG/KG 80 MG/KG 160
MG/KG
____________________________________________________________________________________________________________________________________
DISPOSITION SUMMARY
Animals Initially In Study 10 10 10 10 10 10
Early Deaths
Natural Death 1
Survivors
Terminal Sacrifice 10 10 10 10 10 9
Animals Examined Microscopically 10 10 10 10 10 10
____________________________________________________________________________________________________________________________________
ALIMENTARY SYSTEM
Esophagus (9) (10)
Muscularis, Inflammation, Chronic, Focal 1 (10%)
Liver (10) (10) (10) (10) (10) (10)
Hematopoietic Cell Proliferation 2 (20%) 1 (10%) 10 (100%) 10 (100%) 10 (100%)
Hepatodiaphragmatic Nodule 1 (10%)
Inflammation, Chronic, Multifocal 1 (10%)
Pigmentation 3 (30%)
Bile Duct, Inflammation, Chronic, Focal 1 (10%)
Kupffer Cell, Pigmentation 10 (100%) 10 (100%) 10 (100%)
Pancreas (10) (10)
Acinus, Atrophy 1 (10%)
____________________________________________________________________________________________________________________________________
CARDIOVASCULAR SYSTEM
Heart (10) (10)
Cardiomyopathy 4 (40%) 5 (50%)
____________________________________________________________________________________________________________________________________
ENDOCRINE SYSTEM
Thyroid Gland (10) (1) (10)
Cyst 1 (100%)
Ultimobranchial Cyst 1 (10%)
____________________________________________________________________________________________________________________________________
GENERAL BODY SYSTEM
None
____________________________________________________________________________________________________________________________________
a Number of animals examined microscopically at site and number of animals with lesion
Page 2
NTP Experiment-Test: 61529-01 INCIDENCE RATES OF NONNEOPLASTIC LESIONS BY ANATOMIC SITE (a) Report: PEIRPT03
Study Type: SUBCHRON 90-DAY M-CHLOROANILINE Date: 10/20/04
Route: GAVAGE Time: 08:51:52
____________________________________________________________________________________________________________________________________
FISCHER 344 RATS FEMALE 0 MG/KG 10 MG/KG 20 MG/KG 40 MG/KG 80 MG/KG 160
MG/KG
____________________________________________________________________________________________________________________________________
GENITAL SYSTEM
Clitoral Gland (10) (10)
Inflammation, Chronic 1 (10%)
Inflammation, Chronic, Focal 1 (10%) 1 (10%)
Inflammation, Chronic, Multifocal 3 (30%) 6 (60%)
Inflammation, Chronic, Multifocal,
Suppurative 1 (10%)
____________________________________________________________________________________________________________________________________
HEMATOPOIETIC SYSTEM
Bone Marrow (10) (10) (10) (10) (10) (10)
Infiltration Cellular, Multifocal, Histiocyte 1 (10%)
Infiltration Cellular, Histiocyte 1 (10%) 2 (20%) 3 (30%)
Myelofibrosis 3 (30%) 1 (10%) 1 (10%) 1 (10%)
Pigmentation, Hemosiderin 3 (30%) 10 (100%) 9 (90%)
Erythroid Cell, Hyperplasia 6 (60%) 10 (100%) 10 (100%)
Erythroid Cell, Myelofibrosis 1 (10%)
Lymph Node (1)
Lumbar, Pigmentation 1 (100%)
Lymph Node, Mesenteric (10) (10)
Hyperplasia, Histiocytic 1 (10%)
Spleen (10) (10) (10) (10) (10) (10)
Congestion 8 (80%) 9 (90%) 10 (100%) 10 (100%)
Hematopoietic Cell Proliferation 5 (50%) 8 (80%) 10 (100%) 10 (100%) 9 (90%)
Pigmentation, Hemosiderin 10 (100%) 10 (100%) 9 (90%) 10 (100%) 10 (100%)
Capsule, Fibrosis 6 (60%) 10 (100%) 8 (80%)
Capsule, Fibrosis, Multifocal 1 (10%)
Capsule, Infiltration Cellular 1 (10%) 1 (10%) 9 (90%) 10 (100%) 8 (80%)
Lymphoid Follicle, Atrophy 1 (10%)
____________________________________________________________________________________________________________________________________
INTEGUMENTARY SYSTEM
None
____________________________________________________________________________________________________________________________________
MUSCULOSKELETAL SYSTEM
None
____________________________________________________________________________________________________________________________________
NERVOUS SYSTEM
a Number of animals examined microscopically at site and number of animals with lesion
Page 3
NTP Experiment-Test: 61529-01 INCIDENCE RATES OF NONNEOPLASTIC LESIONS BY ANATOMIC SITE (a) Report: PEIRPT03
Study Type: SUBCHRON 90-DAY M-CHLOROANILINE Date: 10/20/04
Route: GAVAGE Time: 08:51:52
____________________________________________________________________________________________________________________________________
FISCHER 344 RATS FEMALE 0 MG/KG 10 MG/KG 20 MG/KG 40 MG/KG 80 MG/KG 160
MG/KG
____________________________________________________________________________________________________________________________________
None
____________________________________________________________________________________________________________________________________
RESPIRATORY SYSTEM
Lung (10) (10)
Congestion 1 (10%)
Inflammation, Chronic Active, Focal 1 (10%)
Inflammation, Chronic Active, Multifocal 1 (10%)
Arteriole, Inflammation, Granulomatous 1 (10%)
Artery, Mineralization 3 (30%) 5 (50%)
Vein, Mineralization 1 (10%)
Nose (10) (10)
Respiratory Epithelium, Inflammation, Chronic 1 (10%)
____________________________________________________________________________________________________________________________________
SPECIAL SENSES SYSTEM
None
____________________________________________________________________________________________________________________________________
URINARY SYSTEM
Kidney (10) (10) (10) (10) (10) (10)
Mineralization 10 (100%) 10 (100%) 10 (100%) 10 (100%) 10 (100%) 9 (90%)
Cortex, Inflammation, Chronic, Focal 1 (10%)
Cortex, Pigmentation, Hemosiderin 1 (10%) 10 (100%) 10 (100%) 10 (100%)
Renal Tubule, Regeneration, Focal 2 (20%) 1 (10%)
a Number of animals examined microscopically at site and number of animals with lesion
Page 4
NTP Experiment-Test: 61529-01 INCIDENCE RATES OF NONNEOPLASTIC LESIONS BY ANATOMIC SITE (a) Report: PEIRPT03
Study Type: SUBCHRON 90-DAY M-CHLOROANILINE Date: 10/20/04
Route: GAVAGE Time: 08:51:52
____________________________________________________________________________________________________________________________________
FISCHER 344 RATS MALE 0 MG/KG 10 MG/KG 20 MG/KG 40 MG/KG 80 MG/KG 160
MG/KG
____________________________________________________________________________________________________________________________________
DISPOSITION SUMMARY
Animals Initially In Study 10 10 10 10 10 10
Early Deaths
Survivors
Terminal Sacrifice 10 10 10 10 10 10
Animals Examined Microscopically 10 10 10 10 10 10
____________________________________________________________________________________________________________________________________
ALIMENTARY SYSTEM
Liver (10) (10) (10) (10) (10) (10)
Hematopoietic Cell Proliferation 1 (10%) 9 (90%) 9 (90%)
Hemorrhage 1 (10%)
Inflammation, Acute 1 (10%)
Inflammation, Chronic Active 1 (10%)
Necrosis, Focal 1 (10%)
Necrosis, Multifocal 1 (10%)
Vacuolization Cytoplasmic 1 (10%)
Kupffer Cell, Pigmentation 9 (90%) 10 (100%) 9 (90%)
Kupffer Cell, Pigmentation, Hemosiderin 1 (10%)
Pancreas (10) (10)
Acinus, Atrophy 1 (10%)
____________________________________________________________________________________________________________________________________
CARDIOVASCULAR SYSTEM
Heart (10) (10)
Cardiomyopathy 10 (100%) 5 (50%)
____________________________________________________________________________________________________________________________________
ENDOCRINE SYSTEM
Thyroid Gland (10) (10)
Ultimobranchial Cyst 1 (10%) 1 (10%)
____________________________________________________________________________________________________________________________________
GENERAL BODY SYSTEM
None
____________________________________________________________________________________________________________________________________
a Number of animals examined microscopically at site and number of animals with lesion
Page 5
NTP Experiment-Test: 61529-01 INCIDENCE RATES OF NONNEOPLASTIC LESIONS BY ANATOMIC SITE (a) Report: PEIRPT03
Study Type: SUBCHRON 90-DAY M-CHLOROANILINE Date: 10/20/04
Route: GAVAGE Time: 08:51:52
____________________________________________________________________________________________________________________________________
FISCHER 344 RATS MALE 0 MG/KG 10 MG/KG 20 MG/KG 40 MG/KG 80 MG/KG 160
MG/KG
____________________________________________________________________________________________________________________________________
GENITAL SYSTEM
Preputial Gland (10) (10)
Inflammation, Chronic 1 (10%) 4 (40%)
Inflammation, Chronic, Focal 1 (10%)
Inflammation, Chronic, Multifocal 4 (40%)
Inflammation, Chronic, Suppurative 1 (10%) 1 (10%)
Inflammation, Granulomatous 1 (10%)
Testes (10) (10)
Atrophy 1 (10%)
____________________________________________________________________________________________________________________________________
HEMATOPOIETIC SYSTEM
Bone Marrow (10) (10) (10) (10) (10) (10)
Pigmentation, Hemosiderin 10 (100%) 10 (100%)
Erythroid Cell, Hyperplasia 10 (100%) 10 (100%) 10 (100%)
Spleen (10) (10) (10) (10) (10) (10)
Congestion 1 (10%) 9 (90%) 10 (100%) 10 (100%) 10 (100%)
Fibrosis 1 (10%)
Hematopoietic Cell Proliferation 7 (70%) 10 (100%) 10 (100%) 10 (100%) 10 (100%)
Pigmentation, Hemosiderin 6 (60%) 10 (100%) 10 (100%) 10 (100%) 10 (100%)
Capsule, Fibrosis 2 (20%) 2 (20%) 8 (80%) 10 (100%) 10 (100%)
Capsule, Infiltration Cellular 1 (10%) 2 (20%) 2 (20%) 10 (100%) 10 (100%) 10 (100%)
____________________________________________________________________________________________________________________________________
INTEGUMENTARY SYSTEM
None
____________________________________________________________________________________________________________________________________
MUSCULOSKELETAL SYSTEM
None
____________________________________________________________________________________________________________________________________
NERVOUS SYSTEM
None
____________________________________________________________________________________________________________________________________
RESPIRATORY SYSTEM
Lung (10) (10)
a Number of animals examined microscopically at site and number of animals with lesion
Page 6
NTP Experiment-Test: 61529-01 INCIDENCE RATES OF NONNEOPLASTIC LESIONS BY ANATOMIC SITE (a) Report: PEIRPT03
Study Type: SUBCHRON 90-DAY M-CHLOROANILINE Date: 10/20/04
Route: GAVAGE Time: 08:51:52
____________________________________________________________________________________________________________________________________
FISCHER 344 RATS MALE 0 MG/KG 10 MG/KG 20 MG/KG 40 MG/KG 80 MG/KG 160
MG/KG
____________________________________________________________________________________________________________________________________
RESPIRATORY SYSTEM - CONT
Hemorrhage, Focal 1 (10%) 1 (10%)
Alveolar Epithelium, Hyperplasia 1 (10%)
Artery, Mineralization 6 (60%) 5 (50%)
Interstitium, Inflammation, Chronic, Focal 1 (10%)
Interstitium, Inflammation, Chronic,
Multifocal 1 (10%)
Vein, Mineralization 1 (10%)
Nose (10) (10)
Lateral Wall, Inflammation, Granulomatous 1 (10%)
____________________________________________________________________________________________________________________________________
SPECIAL SENSES SYSTEM
None
____________________________________________________________________________________________________________________________________
URINARY SYSTEM
Kidney (10) (10) (10) (10) (10) (10)
Inflammation, Chronic, Multifocal 1 (10%)
Mineralization 10 (100%) 10 (100%) 9 (90%) 10 (100%) 10 (100%) 10 (100%)
Cortex, Pigmentation, Hemosiderin 10 (100%) 10 (100%) 10 (100%)
Renal Tubule, Regeneration, Focal 2 (20%) 1 (10%) 2 (20%)
Renal Tubule, Regeneration, Multifocal 7 (70%) 8 (80%) 7 (70%) 2 (20%)
a Number of animals examined microscopically at site and number of animals with lesion
Page 7
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