TDMS Study 61529-01 Pathology Tables
NTP Experiment-Test: 61529-01 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: SUBCHRON 90-DAY M-CHLOROANILINE Date: 10/20/04
Route: GAVAGE Time: 08:54:27
Facility: Battelle Columbus Laboratory
Chemical CAS #: 108-42-09
Lock Date: 11/16/92
Cage Range: All
Reasons For Removal: All
Removal Date Range: All
Treatment Groups: Include 002 0 MG/KG
Include 001 0 MG/KG
Include 004 10 MG/KG
Include 003 10 MG/KG
Include 006 20 MG/KG
Include 005 20 MG/KG
Include 008 40 MG/KG
Include 007 40 MG/KG
Include 010 80 MG/KG
Include 009 80 MG/KG
Include 012 160 MG/KG
Include 011 160 MG/KG
Page 1
NTP Experiment-Test: 61529-01 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: SUBCHRON 90-DAY M-CHLOROANILINE Date: 10/20/04
Route: GAVAGE Time: 08:54:27
__________________________________________________________________________________________________________________________________
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | |
DAY ON TEST | 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| | |
| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| | |
__________________________________________|__________________________________________________________________________| T (*) |
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | O |
FISCHER 344 RATS FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | T |
ANIMAL ID | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | A |
0 MG/KG | 6| 6| 6| 6| 6| 6| 6| 6| 6| 7| | L |
| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| | |
_____________________________________________________________________________________________________________________|____________|
ALIMENTARY SYSTEM | | |
|__________________________________________________________________________|____________|
Esophagus | + I + + + + + + + + | 9 |
|__________________________________________________________________________|____________|
Intestine Large, Colon | + + + + + + + + + + | 10 |
|__________________________________________________________________________|____________|
Intestine Large, Rectum | + + + + + + + + + + | 10 |
|__________________________________________________________________________|____________|
Intestine Large, Cecum | + + + + + + + + + + | 10 |
|__________________________________________________________________________|____________|
Intestine Small, Duodenum | + + + + + + + + + + | 10 |
|__________________________________________________________________________|____________|
Intestine Small, Jejunum | + + + + + + + + + + | 10 |
|__________________________________________________________________________|____________|
Intestine Small, Ileum | + + + + + + + + + + | 10 |
|__________________________________________________________________________|____________|
Liver | + + + + + + + + + + | 10 |
Hematopoietic Cell Proliferation | 1 1 | 2 1.0|
Hepatodiaphragmatic Nodule | X | 1 |
Inflammation, Chronic, Multifocal | 1 | 1 1.0|
Pigmentation | 1 1 1 | 3 1.0|
|__________________________________________________________________________|____________|
Pancreas | + + + + + + + + + + | 10 |
Acinus, Atrophy | 1 | 1 1.0|
|__________________________________________________________________________|____________|
Salivary Glands | + + + + + + + + + + | 10 |
|__________________________________________________________________________|____________|
Stomach, Forestomach | + + + + + + + + + + | 10 |
|__________________________________________________________________________|____________|
Stomach, Glandular | + + + + + + + + + + | 10 |
_____________________________________________________________________________________________________________________| |
CARDIOVASCULAR SYSTEM | | |
|__________________________________________________________________________|____________|
Blood Vessel | + + + + + + + + + + | 10 |
|__________________________________________________________________________|____________|
_____________________________________________________________________________________________________________________|____________|
* : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade
+ : Tissue examined microscopically M : Missing tissue 1-4 : Lesion qualified as:
X : Lesion present but not qualified A : Autolysis precludes examination 1) Minimal 3) Moderate
I : Insufficient tissue BLANK : Not examined 2) Mild 4) Marked
Page 2
NTP Experiment-Test: 61529-01 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: SUBCHRON 90-DAY M-CHLOROANILINE Date: 10/20/04
Route: GAVAGE Time: 08:54:27
__________________________________________________________________________________________________________________________________
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | |
DAY ON TEST | 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| | |
| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| | |
__________________________________________|__________________________________________________________________________| T (*) |
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | O |
FISCHER 344 RATS FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | T |
ANIMAL ID | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | A |
0 MG/KG | 6| 6| 6| 6| 6| 6| 6| 6| 6| 7| | L |
| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| | |
_____________________________________________________________________________________________________________________|____________|
CARDIOVASCULAR SYSTEM - cont | | |
Heart | + + + + + + + + + + | 10 |
Cardiomyopathy | 1 1 1 1 | 4 1.0|
_____________________________________________________________________________________________________________________| |
ENDOCRINE SYSTEM | | |
|__________________________________________________________________________|____________|
Adrenal Cortex | + + + + + + + + + + | 10 |
|__________________________________________________________________________|____________|
Adrenal Medulla | + + + + + + + + + + | 10 |
|__________________________________________________________________________|____________|
Islets, Pancreatic | + + + + + + + + + + | 10 |
|__________________________________________________________________________|____________|
Parathyroid Gland | + + + + + M + + + + | 9 |
|__________________________________________________________________________|____________|
Pituitary Gland | + + + + + + + + + + | 10 |
|__________________________________________________________________________|____________|
Thyroid Gland | + + + + + + + + + + | 10 |
Ultimobranchial Cyst | 1 | 1 1.0|
_____________________________________________________________________________________________________________________| |
GENERAL BODY SYSTEM | | |
None | | |
_____________________________________________________________________________________________________________________| |
GENITAL SYSTEM | | |
|__________________________________________________________________________|____________|
Clitoral Gland | + + + + + + + + + + | 10 |
Inflammation, Chronic, Focal | 1 | 1 1.0|
Inflammation, Chronic | 1 | 1 1.0|
Inflammation, Chronic, Multifocal | 1 1 1 | 3 1.0|
Inflammation, Chronic, Multifocal, | | |
Suppurative | 1 | 1 1.0|
|__________________________________________________________________________|____________|
Ovary | + + + + + + + + + + | 10 |
|__________________________________________________________________________|____________|
Uterus | + + + + + + + + + + | 10 |
_____________________________________________________________________________________________________________________| |
* : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade
+ : Tissue examined microscopically M : Missing tissue 1-4 : Lesion qualified as:
X : Lesion present but not qualified A : Autolysis precludes examination 1) Minimal 3) Moderate
I : Insufficient tissue BLANK : Not examined 2) Mild 4) Marked
Page 3
NTP Experiment-Test: 61529-01 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: SUBCHRON 90-DAY M-CHLOROANILINE Date: 10/20/04
Route: GAVAGE Time: 08:54:27
__________________________________________________________________________________________________________________________________
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | |
DAY ON TEST | 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| | |
| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| | |
__________________________________________|__________________________________________________________________________| T (*) |
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | O |
FISCHER 344 RATS FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | T |
ANIMAL ID | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | A |
0 MG/KG | 6| 6| 6| 6| 6| 6| 6| 6| 6| 7| | L |
| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| | |
_____________________________________________________________________________________________________________________|____________|
HEMATOPOIETIC SYSTEM | | |
|__________________________________________________________________________|____________|
Bone Marrow | + + + + + + + + + + | 10 |
Myelofibrosis | 2 1 1 | 3 1.3|
|__________________________________________________________________________|____________|
Lymph Node, Mandibular | + + + + + + + + + + | 10 |
|__________________________________________________________________________|____________|
Lymph Node, Mesenteric | + + + + + + + + + + | 10 |
Hyperplasia, Histiocytic | 2 | 1 2.0|
|__________________________________________________________________________|____________|
Spleen | + + + + + + + + + + | 10 |
Capsule, Infiltration Cellular | 1 | 1 1.0|
|__________________________________________________________________________|____________|
Thymus | + + + + + + + + + + | 10 |
_____________________________________________________________________________________________________________________| |
INTEGUMENTARY SYSTEM | | |
|__________________________________________________________________________|____________|
Mammary Gland | + + + + + + + + + + | 10 |
|__________________________________________________________________________|____________|
Skin | + + + + + + + + + + | 10 |
_____________________________________________________________________________________________________________________| |
MUSCULOSKELETAL SYSTEM | | |
|__________________________________________________________________________|____________|
Bone | + + + + + + + + + + | 10 |
_____________________________________________________________________________________________________________________| |
NERVOUS SYSTEM | | |
|__________________________________________________________________________|____________|
Brain | + + + + + + + + + + | 10 |
_____________________________________________________________________________________________________________________| |
RESPIRATORY SYSTEM | | |
|__________________________________________________________________________|____________|
Lung | + + + + + + + + + + | 10 |
Inflammation, Chronic Active, | | |
Multifocal | 1 | 1 1.0|
Artery, Mineralization | 1 1 1 | 3 1.0|
_____________________________________________________________________________________________________________________|____________|
* : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade
+ : Tissue examined microscopically M : Missing tissue 1-4 : Lesion qualified as:
X : Lesion present but not qualified A : Autolysis precludes examination 1) Minimal 3) Moderate
I : Insufficient tissue BLANK : Not examined 2) Mild 4) Marked
Page 4
NTP Experiment-Test: 61529-01 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: SUBCHRON 90-DAY M-CHLOROANILINE Date: 10/20/04
Route: GAVAGE Time: 08:54:27
__________________________________________________________________________________________________________________________________
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | |
DAY ON TEST | 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| | |
| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| | |
__________________________________________|__________________________________________________________________________| T (*) |
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | O |
FISCHER 344 RATS FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | T |
ANIMAL ID | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | A |
0 MG/KG | 6| 6| 6| 6| 6| 6| 6| 6| 6| 7| | L |
| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| | |
_____________________________________________________________________________________________________________________|____________|
RESPIRATORY SYSTEM - cont | | |
|__________________________________________________________________________|____________|
Nose | + + + + + + + + + + | 10 |
|__________________________________________________________________________|____________|
Trachea | + + + + + + + + + + | 10 |
_____________________________________________________________________________________________________________________| |
SPECIAL SENSES SYSTEM | | |
None | | |
_____________________________________________________________________________________________________________________| |
URINARY SYSTEM | | |
|__________________________________________________________________________|____________|
Kidney | + + + + + + + + + + | 10 |
Mineralization | 2 1 1 2 2 1 1 1 2 1 | 10 1.4|
Renal Tubule, Regeneration, Focal | 1 1 | 2 1.0|
|__________________________________________________________________________|____________|
Urinary Bladder | + + + + + + + + + + | 10 |
__________________________________________________________________________________________________________________________________
* : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade
+ : Tissue examined microscopically M : Missing tissue 1-4 : Lesion qualified as:
X : Lesion present but not qualified A : Autolysis precludes examination 1) Minimal 3) Moderate
I : Insufficient tissue BLANK : Not examined 2) Mild 4) Marked
Page 5
NTP Experiment-Test: 61529-01 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: SUBCHRON 90-DAY M-CHLOROANILINE Date: 10/20/04
Route: GAVAGE Time: 08:54:27
__________________________________________________________________________________________________________________________________
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | |
DAY ON TEST | 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| | |
| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| | |
__________________________________________|__________________________________________________________________________| T (*) |
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | O |
FISCHER 344 RATS FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | T |
ANIMAL ID | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | A |
10 MG/KG | 7| 7| 7| 7| 7| 7| 7| 7| 7| 8| | L |
| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| | |
_____________________________________________________________________________________________________________________|____________|
ALIMENTARY SYSTEM | | |
|__________________________________________________________________________|____________|
Liver | + + + + + + + + + + | 10 |
_____________________________________________________________________________________________________________________| |
CARDIOVASCULAR SYSTEM | | |
None | | |
_____________________________________________________________________________________________________________________| |
ENDOCRINE SYSTEM | | |
None | | |
_____________________________________________________________________________________________________________________| |
GENERAL BODY SYSTEM | | |
None | | |
_____________________________________________________________________________________________________________________| |
GENITAL SYSTEM | | |
None | | |
_____________________________________________________________________________________________________________________| |
HEMATOPOIETIC SYSTEM | | |
|__________________________________________________________________________|____________|
Bone Marrow | + + + + + + + + + + | 10 |
Infiltration Cellular, Histiocyte | 1 | 1 1.0|
Myelofibrosis | 1 | 1 1.0|
|__________________________________________________________________________|____________|
Spleen | + + + + + + + + + + | 10 |
Hematopoietic Cell Proliferation | 1 1 1 1 1 | 5 1.0|
Pigmentation, Hemosiderin | 1 1 1 1 1 1 1 1 1 1 | 10 1.0|
Capsule, Infiltration Cellular | 1 | 1 1.0|
_____________________________________________________________________________________________________________________| |
INTEGUMENTARY SYSTEM | | |
None | | |
_____________________________________________________________________________________________________________________| |
MUSCULOSKELETAL SYSTEM | | |
None | | |
_____________________________________________________________________________________________________________________| |
NERVOUS SYSTEM | | |
None | | |
_____________________________________________________________________________________________________________________|____________|
* : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade
+ : Tissue examined microscopically M : Missing tissue 1-4 : Lesion qualified as:
X : Lesion present but not qualified A : Autolysis precludes examination 1) Minimal 3) Moderate
I : Insufficient tissue BLANK : Not examined 2) Mild 4) Marked
Page 6
NTP Experiment-Test: 61529-01 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: SUBCHRON 90-DAY M-CHLOROANILINE Date: 10/20/04
Route: GAVAGE Time: 08:54:27
__________________________________________________________________________________________________________________________________
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | |
DAY ON TEST | 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| | |
| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| | |
__________________________________________|__________________________________________________________________________| T (*) |
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | O |
FISCHER 344 RATS FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | T |
ANIMAL ID | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | A |
10 MG/KG | 7| 7| 7| 7| 7| 7| 7| 7| 7| 8| | L |
| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| | |
_____________________________________________________________________________________________________________________|____________|
RESPIRATORY SYSTEM | | |
None | | |
_____________________________________________________________________________________________________________________| |
SPECIAL SENSES SYSTEM | | |
None | | |
_____________________________________________________________________________________________________________________| |
URINARY SYSTEM | | |
|__________________________________________________________________________|____________|
Kidney | + + + + + + + + + + | 10 |
Mineralization | 2 2 2 1 1 1 1 1 1 1 | 10 1.3|
Cortex, Inflammation, Chronic, Focal | 1 | 1 1.0|
__________________________________________________________________________________________________________________________________
* : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade
+ : Tissue examined microscopically M : Missing tissue 1-4 : Lesion qualified as:
X : Lesion present but not qualified A : Autolysis precludes examination 1) Minimal 3) Moderate
I : Insufficient tissue BLANK : Not examined 2) Mild 4) Marked
Page 7
NTP Experiment-Test: 61529-01 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: SUBCHRON 90-DAY M-CHLOROANILINE Date: 10/20/04
Route: GAVAGE Time: 08:54:27
__________________________________________________________________________________________________________________________________
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | |
DAY ON TEST | 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| | |
| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| | |
__________________________________________|__________________________________________________________________________| T (*) |
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | O |
FISCHER 344 RATS FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | T |
ANIMAL ID | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | A |
20 MG/KG | 8| 8| 8| 8| 8| 8| 8| 8| 8| 9| | L |
| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| | |
_____________________________________________________________________________________________________________________|____________|
ALIMENTARY SYSTEM | | |
|__________________________________________________________________________|____________|
Liver | + + + + + + + + + + | 10 |
Hematopoietic Cell Proliferation | 1 | 1 1.0|
_____________________________________________________________________________________________________________________| |
CARDIOVASCULAR SYSTEM | | |
None | | |
_____________________________________________________________________________________________________________________| |
ENDOCRINE SYSTEM | | |
|__________________________________________________________________________|____________|
Thyroid Gland | + | 1 |
Cyst | 1 | 1 1.0|
_____________________________________________________________________________________________________________________| |
GENERAL BODY SYSTEM | | |
None | | |
_____________________________________________________________________________________________________________________| |
GENITAL SYSTEM | | |
None | | |
_____________________________________________________________________________________________________________________| |
HEMATOPOIETIC SYSTEM | | |
|__________________________________________________________________________|____________|
Bone Marrow | + + + + + + + + + + | 10 |
Infiltration Cellular, Histiocyte | 1 1 | 2 1.0|
|__________________________________________________________________________|____________|
Lymph Node | + | 1 |
Lumbar, Pigmentation | 2 | 1 2.0|
|__________________________________________________________________________|____________|
Spleen | + + + + + + + + + + | 10 |
Congestion | 1 1 1 1 1 1 1 1 | 8 1.0|
Hematopoietic Cell Proliferation | 1 1 1 1 1 1 1 1 | 8 1.0|
Pigmentation, Hemosiderin | 1 1 1 1 1 1 1 1 1 1 | 10 1.0|
_____________________________________________________________________________________________________________________| |
INTEGUMENTARY SYSTEM | | |
None | | |
_____________________________________________________________________________________________________________________| |
MUSCULOSKELETAL SYSTEM | | |
None | | |
_____________________________________________________________________________________________________________________|____________|
* : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade
+ : Tissue examined microscopically M : Missing tissue 1-4 : Lesion qualified as:
X : Lesion present but not qualified A : Autolysis precludes examination 1) Minimal 3) Moderate
I : Insufficient tissue BLANK : Not examined 2) Mild 4) Marked
Page 8
NTP Experiment-Test: 61529-01 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: SUBCHRON 90-DAY M-CHLOROANILINE Date: 10/20/04
Route: GAVAGE Time: 08:54:27
__________________________________________________________________________________________________________________________________
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | |
DAY ON TEST | 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| | |
| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| | |
__________________________________________|__________________________________________________________________________| T (*) |
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | O |
FISCHER 344 RATS FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | T |
ANIMAL ID | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | A |
20 MG/KG | 8| 8| 8| 8| 8| 8| 8| 8| 8| 9| | L |
| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| | |
_____________________________________________________________________________________________________________________|____________|
NERVOUS SYSTEM | | |
None | | |
_____________________________________________________________________________________________________________________| |
RESPIRATORY SYSTEM | | |
None | | |
_____________________________________________________________________________________________________________________| |
SPECIAL SENSES SYSTEM | | |
None | | |
_____________________________________________________________________________________________________________________| |
URINARY SYSTEM | | |
|__________________________________________________________________________|____________|
Kidney | + + + + + + + + + + | 10 |
Mineralization | 1 1 1 1 1 1 1 1 1 1 | 10 1.0|
Cortex, Pigmentation, Hemosiderin | 1 | 1 1.0|
Renal Tubule, Regeneration, Focal | 1 | 1 1.0|
__________________________________________________________________________________________________________________________________
* : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade
+ : Tissue examined microscopically M : Missing tissue 1-4 : Lesion qualified as:
X : Lesion present but not qualified A : Autolysis precludes examination 1) Minimal 3) Moderate
I : Insufficient tissue BLANK : Not examined 2) Mild 4) Marked
Page 9
NTP Experiment-Test: 61529-01 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: SUBCHRON 90-DAY M-CHLOROANILINE Date: 10/20/04
Route: GAVAGE Time: 08:54:27
__________________________________________________________________________________________________________________________________
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | |
DAY ON TEST | 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| | |
| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| | |
__________________________________________|__________________________________________________________________________| T (*) |
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | O |
FISCHER 344 RATS FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | T |
ANIMAL ID | 0| 0| 0| 0| 0| 0| 0| 0| 0| 1| | A |
40 MG/KG | 9| 9| 9| 9| 9| 9| 9| 9| 9| 0| | L |
| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| | |
_____________________________________________________________________________________________________________________|____________|
ALIMENTARY SYSTEM | | |
|__________________________________________________________________________|____________|
Liver | + + + + + + + + + + | 10 |
Hematopoietic Cell Proliferation | 1 1 1 1 1 1 1 1 1 1 | 10 1.0|
Kupffer Cell, Pigmentation | 1 1 1 1 1 1 1 1 1 1 | 10 1.0|
_____________________________________________________________________________________________________________________| |
CARDIOVASCULAR SYSTEM | | |
None | | |
_____________________________________________________________________________________________________________________| |
ENDOCRINE SYSTEM | | |
None | | |
_____________________________________________________________________________________________________________________| |
GENERAL BODY SYSTEM | | |
None | | |
_____________________________________________________________________________________________________________________| |
GENITAL SYSTEM | | |
None | | |
_____________________________________________________________________________________________________________________| |
HEMATOPOIETIC SYSTEM | | |
|__________________________________________________________________________|____________|
Bone Marrow | + + + + + + + + + + | 10 |
Infiltration Cellular, Histiocyte | 1 1 1 | 3 1.0|
Pigmentation, Hemosiderin | 1 1 1 | 3 1.0|
Erythroid Cell, Hyperplasia | 1 1 1 1 1 1 | 6 1.0|
Erythroid Cell, Myelofibrosis | 1 | 1 1.0|
|__________________________________________________________________________|____________|
Spleen | + + + + + + + + + + | 10 |
Congestion | 1 1 1 1 1 1 2 2 2 | 9 1.3|
Hematopoietic Cell Proliferation | 2 1 2 1 1 1 1 2 1 1 | 10 1.3|
Pigmentation, Hemosiderin | 3 3 3 2 2 2 2 2 2 | 9 2.3|
Capsule, Fibrosis | 1 2 1 1 2 1 | 6 1.3|
Capsule, Infiltration Cellular | 2 1 2 1 1 1 2 1 2 | 9 1.4|
_____________________________________________________________________________________________________________________| |
INTEGUMENTARY SYSTEM | | |
None | | |
_____________________________________________________________________________________________________________________|____________|
* : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade
+ : Tissue examined microscopically M : Missing tissue 1-4 : Lesion qualified as:
X : Lesion present but not qualified A : Autolysis precludes examination 1) Minimal 3) Moderate
I : Insufficient tissue BLANK : Not examined 2) Mild 4) Marked
Page 10
NTP Experiment-Test: 61529-01 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: SUBCHRON 90-DAY M-CHLOROANILINE Date: 10/20/04
Route: GAVAGE Time: 08:54:27
__________________________________________________________________________________________________________________________________
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | |
DAY ON TEST | 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| | |
| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| | |
__________________________________________|__________________________________________________________________________| T (*) |
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | O |
FISCHER 344 RATS FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | T |
ANIMAL ID | 0| 0| 0| 0| 0| 0| 0| 0| 0| 1| | A |
40 MG/KG | 9| 9| 9| 9| 9| 9| 9| 9| 9| 0| | L |
| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| | |
_____________________________________________________________________________________________________________________|____________|
MUSCULOSKELETAL SYSTEM | | |
None | | |
_____________________________________________________________________________________________________________________| |
NERVOUS SYSTEM | | |
None | | |
_____________________________________________________________________________________________________________________| |
RESPIRATORY SYSTEM | | |
None | | |
_____________________________________________________________________________________________________________________| |
SPECIAL SENSES SYSTEM | | |
None | | |
_____________________________________________________________________________________________________________________| |
URINARY SYSTEM | | |
|__________________________________________________________________________|____________|
Kidney | + + + + + + + + + + | 10 |
Mineralization | 1 2 2 1 1 1 1 1 1 2 | 10 1.3|
Cortex, Pigmentation, Hemosiderin | 1 2 2 1 1 1 1 1 1 1 | 10 1.2|
__________________________________________________________________________________________________________________________________
* : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade
+ : Tissue examined microscopically M : Missing tissue 1-4 : Lesion qualified as:
X : Lesion present but not qualified A : Autolysis precludes examination 1) Minimal 3) Moderate
I : Insufficient tissue BLANK : Not examined 2) Mild 4) Marked
Page 11
NTP Experiment-Test: 61529-01 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: SUBCHRON 90-DAY M-CHLOROANILINE Date: 10/20/04
Route: GAVAGE Time: 08:54:27
__________________________________________________________________________________________________________________________________
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | |
DAY ON TEST | 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| | |
| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| | |
__________________________________________|__________________________________________________________________________| T (*) |
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | O |
FISCHER 344 RATS FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | T |
ANIMAL ID | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| | A |
80 MG/KG | 0| 0| 0| 0| 0| 0| 0| 0| 0| 1| | L |
| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| | |
_____________________________________________________________________________________________________________________|____________|
ALIMENTARY SYSTEM | | |
|__________________________________________________________________________|____________|
Liver | + + + + + + + + + + | 10 |
Hematopoietic Cell Proliferation | 1 1 1 1 1 1 1 1 1 1 | 10 1.0|
Kupffer Cell, Pigmentation | 1 1 1 1 1 1 1 1 1 1 | 10 1.0|
_____________________________________________________________________________________________________________________| |
CARDIOVASCULAR SYSTEM | | |
None | | |
_____________________________________________________________________________________________________________________| |
ENDOCRINE SYSTEM | | |
None | | |
_____________________________________________________________________________________________________________________| |
GENERAL BODY SYSTEM | | |
None | | |
_____________________________________________________________________________________________________________________| |
GENITAL SYSTEM | | |
None | | |
_____________________________________________________________________________________________________________________| |
HEMATOPOIETIC SYSTEM | | |
|__________________________________________________________________________|____________|
Bone Marrow | + + + + + + + + + + | 10 |
Myelofibrosis | 2 | 1 2.0|
Pigmentation, Hemosiderin | 2 1 1 1 1 1 1 2 2 1 | 10 1.3|
Erythroid Cell, Hyperplasia | 2 2 1 1 2 1 2 2 2 1 | 10 1.6|
|__________________________________________________________________________|____________|
Spleen | + + + + + + + + + + | 10 |
Congestion | 2 2 2 1 2 2 3 3 3 2 | 10 2.2|
Hematopoietic Cell Proliferation | 3 3 3 2 2 3 2 2 2 3 | 10 2.5|
Pigmentation, Hemosiderin | 2 2 1 2 2 2 2 2 2 2 | 10 1.9|
Capsule, Fibrosis | 3 2 2 2 2 3 2 2 2 1 | 10 2.1|
Capsule, Infiltration Cellular | 3 2 2 2 2 2 2 2 2 1 | 10 2.0|
_____________________________________________________________________________________________________________________| |
INTEGUMENTARY SYSTEM | | |
None | | |
_____________________________________________________________________________________________________________________| |
MUSCULOSKELETAL SYSTEM | | |
None | | |
_____________________________________________________________________________________________________________________|____________|
* : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade
+ : Tissue examined microscopically M : Missing tissue 1-4 : Lesion qualified as:
X : Lesion present but not qualified A : Autolysis precludes examination 1) Minimal 3) Moderate
I : Insufficient tissue BLANK : Not examined 2) Mild 4) Marked
Page 12
NTP Experiment-Test: 61529-01 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: SUBCHRON 90-DAY M-CHLOROANILINE Date: 10/20/04
Route: GAVAGE Time: 08:54:27
__________________________________________________________________________________________________________________________________
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | |
DAY ON TEST | 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| | |
| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| | |
__________________________________________|__________________________________________________________________________| T (*) |
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | O |
FISCHER 344 RATS FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | T |
ANIMAL ID | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| | A |
80 MG/KG | 0| 0| 0| 0| 0| 0| 0| 0| 0| 1| | L |
| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| | |
_____________________________________________________________________________________________________________________|____________|
NERVOUS SYSTEM | | |
None | | |
_____________________________________________________________________________________________________________________| |
RESPIRATORY SYSTEM | | |
None | | |
_____________________________________________________________________________________________________________________| |
SPECIAL SENSES SYSTEM | | |
None | | |
_____________________________________________________________________________________________________________________| |
URINARY SYSTEM | | |
|__________________________________________________________________________|____________|
Kidney | + + + + + + + + + + | 10 |
Mineralization | 1 1 1 1 1 1 1 2 2 1 | 10 1.2|
Cortex, Pigmentation, Hemosiderin | 2 2 2 2 2 2 2 2 2 2 | 10 2.0|
__________________________________________________________________________________________________________________________________
* : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade
+ : Tissue examined microscopically M : Missing tissue 1-4 : Lesion qualified as:
X : Lesion present but not qualified A : Autolysis precludes examination 1) Minimal 3) Moderate
I : Insufficient tissue BLANK : Not examined 2) Mild 4) Marked
Page 13
NTP Experiment-Test: 61529-01 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: SUBCHRON 90-DAY M-CHLOROANILINE Date: 10/20/04
Route: GAVAGE Time: 08:54:27
__________________________________________________________________________________________________________________________________
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | |
DAY ON TEST | 7| 9| 9| 9| 9| 9| 9| 9| 9| 9| | |
| 8| 3| 3| 3| 3| 3| 3| 3| 3| 3| | |
__________________________________________|__________________________________________________________________________| T (*) |
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | O |
FISCHER 344 RATS FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | T |
ANIMAL ID | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| | A |
160 | 1| 1| 1| 1| 1| 1| 1| 1| 1| 2| | L |
MG/KG | 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| | |
_____________________________________________________________________________________________________________________|____________|
ALIMENTARY SYSTEM | | |
|__________________________________________________________________________|____________|
Esophagus | + + + + + + + + + + | 10 |
Muscularis, Inflammation, Chronic, | | |
Focal | 1 | 1 1.0|
|__________________________________________________________________________|____________|
Intestine Large, Colon | + + + + + + + + + + | 10 |
|__________________________________________________________________________|____________|
Intestine Large, Rectum | + + + + + + + + + + | 10 |
|__________________________________________________________________________|____________|
Intestine Large, Cecum | A + + + + + + + + + | 9 |
|__________________________________________________________________________|____________|
Intestine Small, Duodenum | + + + + + + + + + + | 10 |
|__________________________________________________________________________|____________|
Intestine Small, Jejunum | A + + + + + + + + + | 9 |
|__________________________________________________________________________|____________|
Intestine Small, Ileum | A + + + + + + + + + | 9 |
|__________________________________________________________________________|____________|
Liver | + + + + + + + + + + | 10 |
Hematopoietic Cell Proliferation | 1 1 1 1 1 1 1 1 1 1 | 10 1.0|
Bile Duct, Inflammation, Chronic, | | |
Focal | 1 | 1 1.0|
Kupffer Cell, Pigmentation | 1 2 2 2 2 1 2 2 2 2 | 10 1.8|
|__________________________________________________________________________|____________|
Pancreas | + + + + + + + + + + | 10 |
|__________________________________________________________________________|____________|
Salivary Glands | + + + + + + + + + + | 10 |
|__________________________________________________________________________|____________|
Stomach, Forestomach | + + + + + + + + + + | 10 |
|__________________________________________________________________________|____________|
Stomach, Glandular | + + + + + + + + + + | 10 |
_____________________________________________________________________________________________________________________| |
CARDIOVASCULAR SYSTEM | | |
|__________________________________________________________________________|____________|
Blood Vessel | + + + + + + + + + + | 10 |
_____________________________________________________________________________________________________________________|____________|
* : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade
+ : Tissue examined microscopically M : Missing tissue 1-4 : Lesion qualified as:
X : Lesion present but not qualified A : Autolysis precludes examination 1) Minimal 3) Moderate
I : Insufficient tissue BLANK : Not examined 2) Mild 4) Marked
Page 14
NTP Experiment-Test: 61529-01 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: SUBCHRON 90-DAY M-CHLOROANILINE Date: 10/20/04
Route: GAVAGE Time: 08:54:27
__________________________________________________________________________________________________________________________________
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | |
DAY ON TEST | 7| 9| 9| 9| 9| 9| 9| 9| 9| 9| | |
| 8| 3| 3| 3| 3| 3| 3| 3| 3| 3| | |
__________________________________________|__________________________________________________________________________| T (*) |
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | O |
FISCHER 344 RATS FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | T |
ANIMAL ID | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| | A |
160 | 1| 1| 1| 1| 1| 1| 1| 1| 1| 2| | L |
MG/KG | 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| | |
_____________________________________________________________________________________________________________________|____________|
CARDIOVASCULAR SYSTEM - cont | | |
|__________________________________________________________________________|____________|
Heart | + + + + + + + + + + | 10 |
Cardiomyopathy | 1 1 1 1 1 | 5 1.0|
_____________________________________________________________________________________________________________________| |
ENDOCRINE SYSTEM | | |
|__________________________________________________________________________|____________|
Adrenal Cortex | + + + + + + + + + + | 10 |
|__________________________________________________________________________|____________|
Adrenal Medulla | + + + + + + + + + + | 10 |
|__________________________________________________________________________|____________|
Islets, Pancreatic | + + + + + + + + + + | 10 |
|__________________________________________________________________________|____________|
Parathyroid Gland | + + + + + + + + + + | 10 |
|__________________________________________________________________________|____________|
Pituitary Gland | + + + + + + + + + + | 10 |
|__________________________________________________________________________|____________|
Thyroid Gland | + + + + + + + + + + | 10 |
_____________________________________________________________________________________________________________________| |
GENERAL BODY SYSTEM | | |
None | | |
_____________________________________________________________________________________________________________________| |
GENITAL SYSTEM | | |
|__________________________________________________________________________|____________|
Clitoral Gland | + + + + + + + + + + | 10 |
Inflammation, Chronic, Focal | 1 | 1 1.0|
Inflammation, Chronic, Multifocal | 1 1 1 1 1 1 | 6 1.0|
|__________________________________________________________________________|____________|
Ovary | + + + + + + + + + + | 10 |
|__________________________________________________________________________|____________|
Uterus | + + + + + + + + + + | 10 |
_____________________________________________________________________________________________________________________| |
HEMATOPOIETIC SYSTEM | | |
|__________________________________________________________________________|____________|
Bone Marrow | + + + + + + + + + + | 10 |
_____________________________________________________________________________________________________________________|____________|
* : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade
+ : Tissue examined microscopically M : Missing tissue 1-4 : Lesion qualified as:
X : Lesion present but not qualified A : Autolysis precludes examination 1) Minimal 3) Moderate
I : Insufficient tissue BLANK : Not examined 2) Mild 4) Marked
Page 15
NTP Experiment-Test: 61529-01 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: SUBCHRON 90-DAY M-CHLOROANILINE Date: 10/20/04
Route: GAVAGE Time: 08:54:27
__________________________________________________________________________________________________________________________________
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | |
DAY ON TEST | 7| 9| 9| 9| 9| 9| 9| 9| 9| 9| | |
| 8| 3| 3| 3| 3| 3| 3| 3| 3| 3| | |
__________________________________________|__________________________________________________________________________| T (*) |
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | O |
FISCHER 344 RATS FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | T |
ANIMAL ID | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| | A |
160 | 1| 1| 1| 1| 1| 1| 1| 1| 1| 2| | L |
MG/KG | 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| | |
_____________________________________________________________________________________________________________________|____________|
HEMATOPOIETIC SYSTEM - cont | | |
Infiltration Cellular, Multifocal, | | |
Histiocyte | 1 | 1 1.0|
Myelofibrosis | 1 | 1 1.0|
Pigmentation, Hemosiderin | 2 2 2 2 2 2 2 2 2 | 9 2.0|
Erythroid Cell, Hyperplasia | 3 3 3 3 3 3 3 3 3 3 | 10 3.0|
|__________________________________________________________________________|____________|
Lymph Node, Mandibular | + + + + + + + + + + | 10 |
|__________________________________________________________________________|____________|
Lymph Node, Mesenteric | + + + + + + + + + + | 10 |
|__________________________________________________________________________|____________|
Spleen | + + + + + + + + + + | 10 |
Congestion | 3 3 3 2 2 3 3 3 3 3 | 10 2.8|
Hematopoietic Cell Proliferation | 2 2 2 2 2 2 2 2 2 | 9 2.0|
Pigmentation, Hemosiderin | 1 3 3 3 3 3 3 3 3 3 | 10 2.8|
Capsule, Fibrosis | 1 2 1 2 2 2 2 1 | 8 1.6|
Capsule, Fibrosis, Multifocal | 1 | 1 1.0|
Capsule, Infiltration Cellular | 2 2 2 1 2 2 2 2 | 8 1.9|
Lymphoid Follicle, Atrophy | 3 | 1 3.0|
|__________________________________________________________________________|____________|
Thymus | + + + + + + + + + + | 10 |
_____________________________________________________________________________________________________________________| |
INTEGUMENTARY SYSTEM | | |
|__________________________________________________________________________|____________|
Mammary Gland | + + + + + + + + + + | 10 |
|__________________________________________________________________________|____________|
Skin | + + + + + + + + + + | 10 |
_____________________________________________________________________________________________________________________| |
MUSCULOSKELETAL SYSTEM | | |
|__________________________________________________________________________|____________|
Bone | + + + + + + + + + + | 10 |
_____________________________________________________________________________________________________________________| |
NERVOUS SYSTEM | | |
|__________________________________________________________________________|____________|
Brain | + + + + + + + + + + | 10 |
_____________________________________________________________________________________________________________________|____________|
* : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade
+ : Tissue examined microscopically M : Missing tissue 1-4 : Lesion qualified as:
X : Lesion present but not qualified A : Autolysis precludes examination 1) Minimal 3) Moderate
I : Insufficient tissue BLANK : Not examined 2) Mild 4) Marked
Page 16
NTP Experiment-Test: 61529-01 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: SUBCHRON 90-DAY M-CHLOROANILINE Date: 10/20/04
Route: GAVAGE Time: 08:54:27
__________________________________________________________________________________________________________________________________
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | |
DAY ON TEST | 7| 9| 9| 9| 9| 9| 9| 9| 9| 9| | |
| 8| 3| 3| 3| 3| 3| 3| 3| 3| 3| | |
__________________________________________|__________________________________________________________________________| T (*) |
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | O |
FISCHER 344 RATS FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | T |
ANIMAL ID | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| | A |
160 | 1| 1| 1| 1| 1| 1| 1| 1| 1| 2| | L |
MG/KG | 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| | |
_____________________________________________________________________________________________________________________|____________|
RESPIRATORY SYSTEM | | |
|__________________________________________________________________________|____________|
Lung | + + + + + + + + + + | 10 |
Congestion | 2 | 1 2.0|
Inflammation, Chronic Active, Focal | 1 | 1 1.0|
Arteriole, Inflammation, | | |
Granulomatous | 1 | 1 1.0|
Artery, Mineralization | 1 1 1 1 1 | 5 1.0|
Vein, Mineralization | 1 | 1 1.0|
|__________________________________________________________________________|____________|
Nose | + + + + + + + + + + | 10 |
Respiratory Epithelium, Inflammation,| | |
Chronic | 2 | 1 2.0|
|__________________________________________________________________________|____________|
Trachea | + + + + + + + + + + | 10 |
_____________________________________________________________________________________________________________________| |
SPECIAL SENSES SYSTEM | | |
None | | |
_____________________________________________________________________________________________________________________| |
URINARY SYSTEM | | |
|__________________________________________________________________________|____________|
Kidney | + + + + + + + + + + | 10 |
Mineralization | 2 1 2 1 2 1 2 2 1 | 9 1.6|
Cortex, Pigmentation, Hemosiderin | 2 3 3 3 3 3 3 3 3 3 | 10 2.9|
|__________________________________________________________________________|____________|
Urinary Bladder | + + + + M + + + + + | 9 |
__________________________________________________________________________________________________________________________________
* : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade
+ : Tissue examined microscopically M : Missing tissue 1-4 : Lesion qualified as:
X : Lesion present but not qualified A : Autolysis precludes examination 1) Minimal 3) Moderate
I : Insufficient tissue BLANK : Not examined 2) Mild 4) Marked
Page 17
NTP Experiment-Test: 61529-01 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: SUBCHRON 90-DAY M-CHLOROANILINE Date: 10/20/04
Route: GAVAGE Time: 08:54:27
__________________________________________________________________________________________________________________________________
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | |
DAY ON TEST | 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| | |
| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| | |
__________________________________________|__________________________________________________________________________| T (*) |
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | O |
FISCHER 344 RATS MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | T |
ANIMAL ID | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | A |
0 MG/KG | 0| 0| 0| 0| 0| 0| 0| 0| 0| 1| | L |
| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| | |
_____________________________________________________________________________________________________________________|____________|
ALIMENTARY SYSTEM | | |
|__________________________________________________________________________|____________|
Esophagus | + + + + + + + + + + | 10 |
|__________________________________________________________________________|____________|
Intestine Large, Colon | + + + + + + + + + + | 10 |
|__________________________________________________________________________|____________|
Intestine Large, Rectum | + + + + + + + + + + | 10 |
|__________________________________________________________________________|____________|
Intestine Large, Cecum | + + + + + + + + + + | 10 |
|__________________________________________________________________________|____________|
Intestine Small, Duodenum | + + + + + + + + + + | 10 |
|__________________________________________________________________________|____________|
Intestine Small, Jejunum | + + + + + + + + + + | 10 |
|__________________________________________________________________________|____________|
Intestine Small, Ileum | + + + + + + + + + + | 10 |
|__________________________________________________________________________|____________|
Liver | + + + + + + + + + + | 10 |
Hemorrhage | 1 | 1 1.0|
Inflammation, Chronic Active | 2 | 1 2.0|
|__________________________________________________________________________|____________|
Pancreas | + + + + + + + + + + | 10 |
|__________________________________________________________________________|____________|
Salivary Glands | + + + + + + + + + + | 10 |
|__________________________________________________________________________|____________|
Stomach, Forestomach | + + + + + + + + + + | 10 |
|__________________________________________________________________________|____________|
Stomach, Glandular | + + + + + + + + + + | 10 |
_____________________________________________________________________________________________________________________| |
CARDIOVASCULAR SYSTEM | | |
|__________________________________________________________________________|____________|
Blood Vessel | + + + + + + + + + + | 10 |
|__________________________________________________________________________|____________|
Heart | + + + + + + + + + + | 10 |
Cardiomyopathy | 1 1 1 2 1 1 1 1 1 1 | 10 1.1|
_____________________________________________________________________________________________________________________| |
_____________________________________________________________________________________________________________________|____________|
* : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade
+ : Tissue examined microscopically M : Missing tissue 1-4 : Lesion qualified as:
X : Lesion present but not qualified A : Autolysis precludes examination 1) Minimal 3) Moderate
I : Insufficient tissue BLANK : Not examined 2) Mild 4) Marked
Page 18
NTP Experiment-Test: 61529-01 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: SUBCHRON 90-DAY M-CHLOROANILINE Date: 10/20/04
Route: GAVAGE Time: 08:54:27
__________________________________________________________________________________________________________________________________
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | |
DAY ON TEST | 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| | |
| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| | |
__________________________________________|__________________________________________________________________________| T (*) |
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | O |
FISCHER 344 RATS MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | T |
ANIMAL ID | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | A |
0 MG/KG | 0| 0| 0| 0| 0| 0| 0| 0| 0| 1| | L |
| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| | |
_____________________________________________________________________________________________________________________|____________|
ENDOCRINE SYSTEM | | |
|__________________________________________________________________________|____________|
Adrenal Cortex | + + + + + + + + + + | 10 |
|__________________________________________________________________________|____________|
Adrenal Medulla | + + + + + + + + + + | 10 |
|__________________________________________________________________________|____________|
Islets, Pancreatic | + + + + + + + + + + | 10 |
|__________________________________________________________________________|____________|
Parathyroid Gland | + + + + + + + + + + | 10 |
|__________________________________________________________________________|____________|
Pituitary Gland | + + + + + + + + + + | 10 |
|__________________________________________________________________________|____________|
Thyroid Gland | + + + + + + + + + + | 10 |
Ultimobranchial Cyst | 1 | 1 1.0|
_____________________________________________________________________________________________________________________| |
GENERAL BODY SYSTEM | | |
None | | |
_____________________________________________________________________________________________________________________| |
GENITAL SYSTEM | | |
|__________________________________________________________________________|____________|
Epididymis | + + + + + + + + + + | 10 |
|__________________________________________________________________________|____________|
Preputial Gland | + + + + + + + + + + | 10 |
Inflammation, Chronic, Focal | 1 | 1 1.0|
Inflammation, Chronic | 1 | 1 1.0|
Inflammation, Chronic, Multifocal | 1 1 1 2 | 4 1.3|
Inflammation, Chronic, Suppurative | 3 | 1 3.0|
|__________________________________________________________________________|____________|
Prostate | + + + + + + + + + + | 10 |
|__________________________________________________________________________|____________|
Seminal Vesicle | + + + + + + + + + + | 10 |
|__________________________________________________________________________|____________|
Testes | + + + + + + + + + + | 10 |
_____________________________________________________________________________________________________________________| |
HEMATOPOIETIC SYSTEM | | |
_____________________________________________________________________________________________________________________|____________|
* : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade
+ : Tissue examined microscopically M : Missing tissue 1-4 : Lesion qualified as:
X : Lesion present but not qualified A : Autolysis precludes examination 1) Minimal 3) Moderate
I : Insufficient tissue BLANK : Not examined 2) Mild 4) Marked
Page 19
NTP Experiment-Test: 61529-01 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: SUBCHRON 90-DAY M-CHLOROANILINE Date: 10/20/04
Route: GAVAGE Time: 08:54:27
__________________________________________________________________________________________________________________________________
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | |
DAY ON TEST | 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| | |
| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| | |
__________________________________________|__________________________________________________________________________| T (*) |
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | O |
FISCHER 344 RATS MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | T |
ANIMAL ID | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | A |
0 MG/KG | 0| 0| 0| 0| 0| 0| 0| 0| 0| 1| | L |
| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| | |
_____________________________________________________________________________________________________________________|____________|
HEMATOPOIETIC SYSTEM - cont | | |
|__________________________________________________________________________|____________|
Bone Marrow | + + + + + + + + + + | 10 |
|__________________________________________________________________________|____________|
Lymph Node, Mandibular | + + + + + + + + + + | 10 |
|__________________________________________________________________________|____________|
Lymph Node, Mesenteric | + + + + + + + + + + | 10 |
|__________________________________________________________________________|____________|
Spleen | + + + + + + + + + + | 10 |
Capsule, Infiltration Cellular | 1 | 1 1.0|
|__________________________________________________________________________|____________|
Thymus | + + + + + + + + + + | 10 |
_____________________________________________________________________________________________________________________| |
INTEGUMENTARY SYSTEM | | |
|__________________________________________________________________________|____________|
Mammary Gland | + + + M + + M + + + | 8 |
|__________________________________________________________________________|____________|
Skin | + + + + + + + + + + | 10 |
_____________________________________________________________________________________________________________________| |
MUSCULOSKELETAL SYSTEM | | |
|__________________________________________________________________________|____________|
Bone | + + + + + + + + + + | 10 |
_____________________________________________________________________________________________________________________| |
NERVOUS SYSTEM | | |
|__________________________________________________________________________|____________|
Brain | + + + + + + + + + + | 10 |
|__________________________________________________________________________|____________|
Spinal Cord | + | 1 |
_____________________________________________________________________________________________________________________| |
RESPIRATORY SYSTEM | | |
|__________________________________________________________________________|____________|
Lung | + + + + + + + + + + | 10 |
Hemorrhage, Focal | 1 | 1 1.0|
Alveolar Epithelium, Hyperplasia | 1 | 1 1.0|
Artery, Mineralization | 1 1 1 1 1 1 | 6 1.0|
_____________________________________________________________________________________________________________________|____________|
* : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade
+ : Tissue examined microscopically M : Missing tissue 1-4 : Lesion qualified as:
X : Lesion present but not qualified A : Autolysis precludes examination 1) Minimal 3) Moderate
I : Insufficient tissue BLANK : Not examined 2) Mild 4) Marked
Page 20
NTP Experiment-Test: 61529-01 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: SUBCHRON 90-DAY M-CHLOROANILINE Date: 10/20/04
Route: GAVAGE Time: 08:54:27
__________________________________________________________________________________________________________________________________
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | |
DAY ON TEST | 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| | |
| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| | |
__________________________________________|__________________________________________________________________________| T (*) |
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | O |
FISCHER 344 RATS MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | T |
ANIMAL ID | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | A |
0 MG/KG | 0| 0| 0| 0| 0| 0| 0| 0| 0| 1| | L |
| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| | |
_____________________________________________________________________________________________________________________|____________|
RESPIRATORY SYSTEM - cont | | |
Interstitium, Inflammation, Chronic, | | |
Focal | 1 | 1 1.0|
|__________________________________________________________________________|____________|
Nose | + + + + + + + + + + | 10 |
Lateral Wall, Inflammation, | | |
Granulomatous | 1 | 1 1.0|
|__________________________________________________________________________|____________|
Trachea | + + + + + + + + + + | 10 |
_____________________________________________________________________________________________________________________| |
SPECIAL SENSES SYSTEM | | |
None | | |
_____________________________________________________________________________________________________________________| |
URINARY SYSTEM | | |
|__________________________________________________________________________|____________|
Kidney | + + + + + + + + + + | 10 |
Mineralization | 1 1 1 1 1 1 2 1 2 1 | 10 1.2|
Renal Tubule, Regeneration, Focal | 1 1 | 2 1.0|
Renal Tubule, Regeneration, | | |
Multifocal | 2 1 1 1 2 1 1 | 7 1.3|
|__________________________________________________________________________|____________|
Urinary Bladder | + + + + + + + + + + | 10 |
__________________________________________________________________________________________________________________________________
* : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade
+ : Tissue examined microscopically M : Missing tissue 1-4 : Lesion qualified as:
X : Lesion present but not qualified A : Autolysis precludes examination 1) Minimal 3) Moderate
I : Insufficient tissue BLANK : Not examined 2) Mild 4) Marked
Page 21
NTP Experiment-Test: 61529-01 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: SUBCHRON 90-DAY M-CHLOROANILINE Date: 10/20/04
Route: GAVAGE Time: 08:54:27
__________________________________________________________________________________________________________________________________
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | |
DAY ON TEST | 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| | |
| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| | |
__________________________________________|__________________________________________________________________________| T (*) |
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | O |
FISCHER 344 RATS MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | T |
ANIMAL ID | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | A |
10 MG/KG | 1| 1| 1| 1| 1| 1| 1| 1| 1| 2| | L |
| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| | |
_____________________________________________________________________________________________________________________|____________|
ALIMENTARY SYSTEM | | |
|__________________________________________________________________________|____________|
Liver | + + + + + + + + + + | 10 |
Hematopoietic Cell Proliferation | 1 | 1 1.0|
Inflammation, Acute | 1 | 1 1.0|
Necrosis, Focal | 1 | 1 1.0|
Necrosis, Multifocal | 1 | 1 1.0|
_____________________________________________________________________________________________________________________| |
CARDIOVASCULAR SYSTEM | | |
None | | |
_____________________________________________________________________________________________________________________| |
ENDOCRINE SYSTEM | | |
None | | |
_____________________________________________________________________________________________________________________| |
GENERAL BODY SYSTEM | | |
None | | |
_____________________________________________________________________________________________________________________| |
GENITAL SYSTEM | | |
None | | |
_____________________________________________________________________________________________________________________| |
HEMATOPOIETIC SYSTEM | | |
|__________________________________________________________________________|____________|
Bone Marrow | + + + + + + + + + + | 10 |
|__________________________________________________________________________|____________|
Spleen | + + + + + + + + + + | 10 |
Congestion | 1 | 1 1.0|
Hematopoietic Cell Proliferation | 1 1 1 1 1 1 1 | 7 1.0|
Pigmentation, Hemosiderin | 1 1 1 1 1 1 | 6 1.0|
Capsule, Fibrosis | 1 1 | 2 1.0|
Capsule, Infiltration Cellular | 1 1 | 2 1.0|
_____________________________________________________________________________________________________________________| |
INTEGUMENTARY SYSTEM | | |
None | | |
_____________________________________________________________________________________________________________________| |
MUSCULOSKELETAL SYSTEM | | |
None | | |
_____________________________________________________________________________________________________________________|____________|
* : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade
+ : Tissue examined microscopically M : Missing tissue 1-4 : Lesion qualified as:
X : Lesion present but not qualified A : Autolysis precludes examination 1) Minimal 3) Moderate
I : Insufficient tissue BLANK : Not examined 2) Mild 4) Marked
Page 22
NTP Experiment-Test: 61529-01 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: SUBCHRON 90-DAY M-CHLOROANILINE Date: 10/20/04
Route: GAVAGE Time: 08:54:27
__________________________________________________________________________________________________________________________________
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | |
DAY ON TEST | 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| | |
| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| | |
__________________________________________|__________________________________________________________________________| T (*) |
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | O |
FISCHER 344 RATS MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | T |
ANIMAL ID | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | A |
10 MG/KG | 1| 1| 1| 1| 1| 1| 1| 1| 1| 2| | L |
| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| | |
_____________________________________________________________________________________________________________________|____________|
NERVOUS SYSTEM | | |
None | | |
_____________________________________________________________________________________________________________________| |
RESPIRATORY SYSTEM | | |
None | | |
_____________________________________________________________________________________________________________________| |
SPECIAL SENSES SYSTEM | | |
None | | |
_____________________________________________________________________________________________________________________| |
URINARY SYSTEM | | |
|__________________________________________________________________________|____________|
Kidney | + + + + + + + + + + | 10 |
Inflammation, Chronic, Multifocal | 1 | 1 1.0|
Mineralization | 1 1 1 1 1 1 1 1 1 1 | 10 1.0|
Renal Tubule, Regeneration, | | |
Multifocal | 1 1 1 1 1 1 1 1 | 8 1.0|
__________________________________________________________________________________________________________________________________
* : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade
+ : Tissue examined microscopically M : Missing tissue 1-4 : Lesion qualified as:
X : Lesion present but not qualified A : Autolysis precludes examination 1) Minimal 3) Moderate
I : Insufficient tissue BLANK : Not examined 2) Mild 4) Marked
Page 23
NTP Experiment-Test: 61529-01 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: SUBCHRON 90-DAY M-CHLOROANILINE Date: 10/20/04
Route: GAVAGE Time: 08:54:27
__________________________________________________________________________________________________________________________________
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | |
DAY ON TEST | 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| | |
| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| | |
__________________________________________|__________________________________________________________________________| T (*) |
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | O |
FISCHER 344 RATS MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | T |
ANIMAL ID | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | A |
20 MG/KG | 2| 2| 2| 2| 2| 2| 2| 2| 2| 3| | L |
| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| | |
_____________________________________________________________________________________________________________________|____________|
ALIMENTARY SYSTEM | | |
|__________________________________________________________________________|____________|
Liver | + + + + + + + + + + | 10 |
_____________________________________________________________________________________________________________________| |
CARDIOVASCULAR SYSTEM | | |
None | | |
_____________________________________________________________________________________________________________________| |
ENDOCRINE SYSTEM | | |
None | | |
_____________________________________________________________________________________________________________________| |
GENERAL BODY SYSTEM | | |
None | | |
_____________________________________________________________________________________________________________________| |
GENITAL SYSTEM | | |
None | | |
_____________________________________________________________________________________________________________________| |
HEMATOPOIETIC SYSTEM | | |
|__________________________________________________________________________|____________|
Bone Marrow | + + + + + + + + + + | 10 |
|__________________________________________________________________________|____________|
Spleen | + + + + + + + + + + | 10 |
Congestion | 1 2 1 1 1 1 1 1 1 | 9 1.1|
Fibrosis | 1 | 1 1.0|
Hematopoietic Cell Proliferation | 1 1 1 1 1 1 1 1 1 1 | 10 1.0|
Pigmentation, Hemosiderin | 1 1 1 1 1 1 1 1 1 1 | 10 1.0|
Capsule, Fibrosis | 1 1 | 2 1.0|
Capsule, Infiltration Cellular | 1 1 | 2 1.0|
_____________________________________________________________________________________________________________________| |
INTEGUMENTARY SYSTEM | | |
None | | |
_____________________________________________________________________________________________________________________| |
MUSCULOSKELETAL SYSTEM | | |
None | | |
_____________________________________________________________________________________________________________________| |
NERVOUS SYSTEM | | |
None | | |
_____________________________________________________________________________________________________________________|____________|
* : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade
+ : Tissue examined microscopically M : Missing tissue 1-4 : Lesion qualified as:
X : Lesion present but not qualified A : Autolysis precludes examination 1) Minimal 3) Moderate
I : Insufficient tissue BLANK : Not examined 2) Mild 4) Marked
Page 24
NTP Experiment-Test: 61529-01 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: SUBCHRON 90-DAY M-CHLOROANILINE Date: 10/20/04
Route: GAVAGE Time: 08:54:27
__________________________________________________________________________________________________________________________________
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | |
DAY ON TEST | 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| | |
| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| | |
__________________________________________|__________________________________________________________________________| T (*) |
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | O |
FISCHER 344 RATS MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | T |
ANIMAL ID | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | A |
20 MG/KG | 2| 2| 2| 2| 2| 2| 2| 2| 2| 3| | L |
| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| | |
_____________________________________________________________________________________________________________________|____________|
RESPIRATORY SYSTEM | | |
None | | |
_____________________________________________________________________________________________________________________| |
SPECIAL SENSES SYSTEM | | |
None | | |
_____________________________________________________________________________________________________________________| |
URINARY SYSTEM | | |
|__________________________________________________________________________|____________|
Kidney | + + + + + + + + + + | 10 |
Mineralization | 1 1 1 1 1 1 1 1 1 | 9 1.0|
Renal Tubule, Regeneration, | | |
Multifocal | 1 1 1 1 1 1 1 | 7 1.0|
__________________________________________________________________________________________________________________________________
* : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade
+ : Tissue examined microscopically M : Missing tissue 1-4 : Lesion qualified as:
X : Lesion present but not qualified A : Autolysis precludes examination 1) Minimal 3) Moderate
I : Insufficient tissue BLANK : Not examined 2) Mild 4) Marked
Page 25
NTP Experiment-Test: 61529-01 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: SUBCHRON 90-DAY M-CHLOROANILINE Date: 10/20/04
Route: GAVAGE Time: 08:54:27
__________________________________________________________________________________________________________________________________
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | |
DAY ON TEST | 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| | |
| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| | |
__________________________________________|__________________________________________________________________________| T (*) |
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | O |
FISCHER 344 RATS MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | T |
ANIMAL ID | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | A |
40 MG/KG | 3| 3| 3| 3| 3| 3| 3| 3| 3| 4| | L |
| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| | |
_____________________________________________________________________________________________________________________|____________|
ALIMENTARY SYSTEM | | |
|__________________________________________________________________________|____________|
Liver | + + + + + + + + + + | 10 |
Vacuolization Cytoplasmic | 1 | 1 1.0|
Kupffer Cell, Pigmentation | 1 1 1 1 1 1 1 1 1 | 9 1.0|
_____________________________________________________________________________________________________________________| |
CARDIOVASCULAR SYSTEM | | |
None | | |
_____________________________________________________________________________________________________________________| |
ENDOCRINE SYSTEM | | |
None | | |
_____________________________________________________________________________________________________________________| |
GENERAL BODY SYSTEM | | |
None | | |
_____________________________________________________________________________________________________________________| |
GENITAL SYSTEM | | |
None | | |
_____________________________________________________________________________________________________________________| |
HEMATOPOIETIC SYSTEM | | |
|__________________________________________________________________________|____________|
Bone Marrow | + + + + + + + + + + | 10 |
Erythroid Cell, Hyperplasia | 1 1 1 1 1 1 1 1 1 1 | 10 1.0|
|__________________________________________________________________________|____________|
Spleen | + + + + + + + + + + | 10 |
Congestion | 2 3 2 2 2 2 3 3 2 2 | 10 2.3|
Hematopoietic Cell Proliferation | 2 1 2 2 1 1 1 1 2 2 | 10 1.5|
Pigmentation, Hemosiderin | 2 2 2 2 2 2 2 1 1 2 | 10 1.8|
Capsule, Fibrosis | 2 1 1 1 1 1 2 1 | 8 1.3|
Capsule, Infiltration Cellular | 3 2 2 2 2 2 2 2 1 2 | 10 2.0|
_____________________________________________________________________________________________________________________| |
INTEGUMENTARY SYSTEM | | |
None | | |
_____________________________________________________________________________________________________________________| |
MUSCULOSKELETAL SYSTEM | | |
None | | |
_____________________________________________________________________________________________________________________|____________|
* : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade
+ : Tissue examined microscopically M : Missing tissue 1-4 : Lesion qualified as:
X : Lesion present but not qualified A : Autolysis precludes examination 1) Minimal 3) Moderate
I : Insufficient tissue BLANK : Not examined 2) Mild 4) Marked
Page 26
NTP Experiment-Test: 61529-01 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: SUBCHRON 90-DAY M-CHLOROANILINE Date: 10/20/04
Route: GAVAGE Time: 08:54:27
__________________________________________________________________________________________________________________________________
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | |
DAY ON TEST | 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| | |
| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| | |
__________________________________________|__________________________________________________________________________| T (*) |
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | O |
FISCHER 344 RATS MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | T |
ANIMAL ID | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | A |
40 MG/KG | 3| 3| 3| 3| 3| 3| 3| 3| 3| 4| | L |
| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| | |
_____________________________________________________________________________________________________________________|____________|
NERVOUS SYSTEM | | |
None | | |
_____________________________________________________________________________________________________________________| |
RESPIRATORY SYSTEM | | |
None | | |
_____________________________________________________________________________________________________________________| |
SPECIAL SENSES SYSTEM | | |
None | | |
_____________________________________________________________________________________________________________________| |
URINARY SYSTEM | | |
|__________________________________________________________________________|____________|
Kidney | + + + + + + + + + + | 10 |
Mineralization | 1 1 1 1 1 1 2 1 2 2 | 10 1.3|
Cortex, Pigmentation, Hemosiderin | 1 1 1 1 1 1 1 1 3 1 | 10 1.2|
Renal Tubule, Regeneration, Focal | 1 | 1 1.0|
Renal Tubule, Regeneration, | | |
Multifocal | 1 1 | 2 1.0|
__________________________________________________________________________________________________________________________________
* : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade
+ : Tissue examined microscopically M : Missing tissue 1-4 : Lesion qualified as:
X : Lesion present but not qualified A : Autolysis precludes examination 1) Minimal 3) Moderate
I : Insufficient tissue BLANK : Not examined 2) Mild 4) Marked
Page 27
NTP Experiment-Test: 61529-01 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: SUBCHRON 90-DAY M-CHLOROANILINE Date: 10/20/04
Route: GAVAGE Time: 08:54:27
__________________________________________________________________________________________________________________________________
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | |
DAY ON TEST | 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| | |
| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| | |
__________________________________________|__________________________________________________________________________| T (*) |
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | O |
FISCHER 344 RATS MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | T |
ANIMAL ID | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | A |
80 MG/KG | 4| 4| 4| 4| 4| 4| 4| 4| 4| 5| | L |
| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| | |
_____________________________________________________________________________________________________________________|____________|
ALIMENTARY SYSTEM | | |
|__________________________________________________________________________|____________|
Liver | + + + + + + + + + + | 10 |
Hematopoietic Cell Proliferation | 1 1 1 1 1 1 1 1 1 | 9 1.0|
Kupffer Cell, Pigmentation | 1 1 1 1 1 1 1 1 1 1 | 10 1.0|
_____________________________________________________________________________________________________________________| |
CARDIOVASCULAR SYSTEM | | |
None | | |
_____________________________________________________________________________________________________________________| |
ENDOCRINE SYSTEM | | |
None | | |
_____________________________________________________________________________________________________________________| |
GENERAL BODY SYSTEM | | |
None | | |
_____________________________________________________________________________________________________________________| |
GENITAL SYSTEM | | |
None | | |
_____________________________________________________________________________________________________________________| |
HEMATOPOIETIC SYSTEM | | |
|__________________________________________________________________________|____________|
Bone Marrow | + + + + + + + + + + | 10 |
Pigmentation, Hemosiderin | 2 1 1 1 2 2 1 2 1 2 | 10 1.5|
Erythroid Cell, Hyperplasia | 2 2 1 1 2 2 1 2 1 2 | 10 1.6|
|__________________________________________________________________________|____________|
Spleen | + + + + + + + + + + | 10 |
Congestion | 3 3 2 3 3 3 3 3 3 3 | 10 2.9|
Hematopoietic Cell Proliferation | 1 1 1 1 1 1 1 2 1 2 | 10 1.2|
Pigmentation, Hemosiderin | 2 1 2 2 1 2 1 2 1 1 | 10 1.5|
Capsule, Fibrosis | 2 2 3 3 2 2 3 2 2 2 | 10 2.3|
Capsule, Infiltration Cellular | 2 2 3 3 2 2 2 3 2 3 | 10 2.4|
_____________________________________________________________________________________________________________________| |
INTEGUMENTARY SYSTEM | | |
None | | |
_____________________________________________________________________________________________________________________| |
MUSCULOSKELETAL SYSTEM | | |
None | | |
_____________________________________________________________________________________________________________________|____________|
* : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade
+ : Tissue examined microscopically M : Missing tissue 1-4 : Lesion qualified as:
X : Lesion present but not qualified A : Autolysis precludes examination 1) Minimal 3) Moderate
I : Insufficient tissue BLANK : Not examined 2) Mild 4) Marked
Page 28
NTP Experiment-Test: 61529-01 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: SUBCHRON 90-DAY M-CHLOROANILINE Date: 10/20/04
Route: GAVAGE Time: 08:54:27
__________________________________________________________________________________________________________________________________
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | |
DAY ON TEST | 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| | |
| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| | |
__________________________________________|__________________________________________________________________________| T (*) |
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | O |
FISCHER 344 RATS MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | T |
ANIMAL ID | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | A |
80 MG/KG | 4| 4| 4| 4| 4| 4| 4| 4| 4| 5| | L |
| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| | |
_____________________________________________________________________________________________________________________|____________|
NERVOUS SYSTEM | | |
None | | |
_____________________________________________________________________________________________________________________| |
RESPIRATORY SYSTEM | | |
None | | |
_____________________________________________________________________________________________________________________| |
SPECIAL SENSES SYSTEM | | |
None | | |
_____________________________________________________________________________________________________________________| |
URINARY SYSTEM | | |
|__________________________________________________________________________|____________|
Kidney | + + + + + + + + + + | 10 |
Mineralization | 1 2 1 1 1 1 1 1 1 1 | 10 1.1|
Cortex, Pigmentation, Hemosiderin | 1 2 1 1 2 2 2 2 2 2 | 10 1.7|
Renal Tubule, Regeneration, Focal | 1 1 | 2 1.0|
__________________________________________________________________________________________________________________________________
* : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade
+ : Tissue examined microscopically M : Missing tissue 1-4 : Lesion qualified as:
X : Lesion present but not qualified A : Autolysis precludes examination 1) Minimal 3) Moderate
I : Insufficient tissue BLANK : Not examined 2) Mild 4) Marked
Page 29
NTP Experiment-Test: 61529-01 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: SUBCHRON 90-DAY M-CHLOROANILINE Date: 10/20/04
Route: GAVAGE Time: 08:54:27
__________________________________________________________________________________________________________________________________
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | |
DAY ON TEST | 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| | |
| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| | |
__________________________________________|__________________________________________________________________________| T (*) |
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | O |
FISCHER 344 RATS MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | T |
ANIMAL ID | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | A |
160 | 5| 5| 5| 5| 5| 5| 5| 5| 5| 6| | L |
MG/KG | 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| | |
_____________________________________________________________________________________________________________________|____________|
ALIMENTARY SYSTEM | | |
|__________________________________________________________________________|____________|
Esophagus | + + + + + + + + + + | 10 |
|__________________________________________________________________________|____________|
Intestine Large, Colon | + + + + + + + + + + | 10 |
|__________________________________________________________________________|____________|
Intestine Large, Rectum | + + + + + + + + + + | 10 |
|__________________________________________________________________________|____________|
Intestine Large, Cecum | + + + + + + + + + + | 10 |
|__________________________________________________________________________|____________|
Intestine Small, Duodenum | + + + + + + + + + + | 10 |
|__________________________________________________________________________|____________|
Intestine Small, Jejunum | + + + + + + + + + + | 10 |
|__________________________________________________________________________|____________|
Intestine Small, Ileum | + + + + + + + + + + | 10 |
|__________________________________________________________________________|____________|
Liver | + + + + + + + + + + | 10 |
Hematopoietic Cell Proliferation | 1 1 1 1 1 1 1 1 1 | 9 1.0|
Kupffer Cell, Pigmentation, | | |
Hemosiderin | 2 | 1 2.0|
Kupffer Cell, Pigmentation | 1 1 2 1 1 1 1 1 1 | 9 1.1|
|__________________________________________________________________________|____________|
Pancreas | + + + + + + + + + + | 10 |
Acinus, Atrophy | 1 | 1 1.0|
|__________________________________________________________________________|____________|
Salivary Glands | + + + + + + + + + + | 10 |
|__________________________________________________________________________|____________|
Stomach, Forestomach | + + + + + + + + + + | 10 |
|__________________________________________________________________________|____________|
Stomach, Glandular | + + + + + + + + + + | 10 |
_____________________________________________________________________________________________________________________| |
CARDIOVASCULAR SYSTEM | | |
|__________________________________________________________________________|____________|
Blood Vessel | + + + + + + + + + + | 10 |
|__________________________________________________________________________|____________|
_____________________________________________________________________________________________________________________|____________|
* : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade
+ : Tissue examined microscopically M : Missing tissue 1-4 : Lesion qualified as:
X : Lesion present but not qualified A : Autolysis precludes examination 1) Minimal 3) Moderate
I : Insufficient tissue BLANK : Not examined 2) Mild 4) Marked
Page 30
NTP Experiment-Test: 61529-01 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: SUBCHRON 90-DAY M-CHLOROANILINE Date: 10/20/04
Route: GAVAGE Time: 08:54:27
__________________________________________________________________________________________________________________________________
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | |
DAY ON TEST | 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| | |
| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| | |
__________________________________________|__________________________________________________________________________| T (*) |
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | O |
FISCHER 344 RATS MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | T |
ANIMAL ID | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | A |
160 | 5| 5| 5| 5| 5| 5| 5| 5| 5| 6| | L |
MG/KG | 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| | |
_____________________________________________________________________________________________________________________|____________|
CARDIOVASCULAR SYSTEM - cont | | |
Heart | + + + + + + + + + + | 10 |
Cardiomyopathy | 1 1 1 1 1 | 5 1.0|
_____________________________________________________________________________________________________________________| |
ENDOCRINE SYSTEM | | |
|__________________________________________________________________________|____________|
Adrenal Cortex | + + + + + + + + + + | 10 |
|__________________________________________________________________________|____________|
Adrenal Medulla | + + + + + + + + + + | 10 |
|__________________________________________________________________________|____________|
Islets, Pancreatic | + + + + + + + + + + | 10 |
|__________________________________________________________________________|____________|
Parathyroid Gland | + + + + + + + M + M | 8 |
|__________________________________________________________________________|____________|
Pituitary Gland | + + + + + + + + + + | 10 |
|__________________________________________________________________________|____________|
Thyroid Gland | + + + + + + + + + + | 10 |
Ultimobranchial Cyst | 1 | 1 1.0|
_____________________________________________________________________________________________________________________| |
GENERAL BODY SYSTEM | | |
None | | |
_____________________________________________________________________________________________________________________| |
GENITAL SYSTEM | | |
|__________________________________________________________________________|____________|
Epididymis | + + + + + + + + + + | 10 |
|__________________________________________________________________________|____________|
Preputial Gland | + + + + + + + + + + | 10 |
Inflammation, Chronic | 1 1 1 1 | 4 1.0|
Inflammation, Chronic, Suppurative | 2 | 1 2.0|
Inflammation, Granulomatous | 1 | 1 1.0|
|__________________________________________________________________________|____________|
Prostate | + + + + + + + + + + | 10 |
|__________________________________________________________________________|____________|
Seminal Vesicle | + + + + + + + + + + | 10 |
|__________________________________________________________________________|____________|
_____________________________________________________________________________________________________________________|____________|
* : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade
+ : Tissue examined microscopically M : Missing tissue 1-4 : Lesion qualified as:
X : Lesion present but not qualified A : Autolysis precludes examination 1) Minimal 3) Moderate
I : Insufficient tissue BLANK : Not examined 2) Mild 4) Marked
Page 31
NTP Experiment-Test: 61529-01 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: SUBCHRON 90-DAY M-CHLOROANILINE Date: 10/20/04
Route: GAVAGE Time: 08:54:27
__________________________________________________________________________________________________________________________________
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | |
DAY ON TEST | 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| | |
| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| | |
__________________________________________|__________________________________________________________________________| T (*) |
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | O |
FISCHER 344 RATS MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | T |
ANIMAL ID | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | A |
160 | 5| 5| 5| 5| 5| 5| 5| 5| 5| 6| | L |
MG/KG | 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| | |
_____________________________________________________________________________________________________________________|____________|
GENITAL SYSTEM - cont | | |
Testes | + + + + + + + + + + | 10 |
Atrophy | 2 | 1 2.0|
_____________________________________________________________________________________________________________________| |
HEMATOPOIETIC SYSTEM | | |
|__________________________________________________________________________|____________|
Bone Marrow | + + + + + + + + + + | 10 |
Pigmentation, Hemosiderin | 3 2 2 1 2 2 1 2 2 2 | 10 1.9|
Erythroid Cell, Hyperplasia | 3 3 3 3 3 3 2 3 3 3 | 10 2.9|
|__________________________________________________________________________|____________|
Lymph Node, Mandibular | + + + + + + + + + + | 10 |
|__________________________________________________________________________|____________|
Lymph Node, Mesenteric | + + + + + + + + + + | 10 |
|__________________________________________________________________________|____________|
Spleen | + + + + + + + + + + | 10 |
Congestion | 3 3 3 3 3 3 3 3 3 3 | 10 3.0|
Hematopoietic Cell Proliferation | 2 1 2 1 2 2 2 2 2 2 | 10 1.8|
Pigmentation, Hemosiderin | 2 1 3 2 2 3 3 3 2 3 | 10 2.4|
Capsule, Fibrosis | 2 2 2 2 2 2 2 2 2 2 | 10 2.0|
Capsule, Infiltration Cellular | 2 2 2 2 2 2 2 2 2 2 | 10 2.0|
|__________________________________________________________________________|____________|
Thymus | + + + + + + + + + + | 10 |
_____________________________________________________________________________________________________________________| |
INTEGUMENTARY SYSTEM | | |
|__________________________________________________________________________|____________|
Mammary Gland | + M + + + + + + + + | 9 |
|__________________________________________________________________________|____________|
Skin | + + + + + + + + + + | 10 |
_____________________________________________________________________________________________________________________| |
MUSCULOSKELETAL SYSTEM | | |
|__________________________________________________________________________|____________|
Bone | + + + + + + + + + + | 10 |
_____________________________________________________________________________________________________________________| |
NERVOUS SYSTEM | | |
|__________________________________________________________________________|____________|
_____________________________________________________________________________________________________________________|____________|
* : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade
+ : Tissue examined microscopically M : Missing tissue 1-4 : Lesion qualified as:
X : Lesion present but not qualified A : Autolysis precludes examination 1) Minimal 3) Moderate
I : Insufficient tissue BLANK : Not examined 2) Mild 4) Marked
Page 32
NTP Experiment-Test: 61529-01 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: SUBCHRON 90-DAY M-CHLOROANILINE Date: 10/20/04
Route: GAVAGE Time: 08:54:27
__________________________________________________________________________________________________________________________________
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | |
DAY ON TEST | 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| | |
| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| | |
__________________________________________|__________________________________________________________________________| T (*) |
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | O |
FISCHER 344 RATS MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | T |
ANIMAL ID | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | A |
160 | 5| 5| 5| 5| 5| 5| 5| 5| 5| 6| | L |
MG/KG | 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| | |
_____________________________________________________________________________________________________________________|____________|
NERVOUS SYSTEM - cont | | |
Brain | + + + + + + + + + + | 10 |
_____________________________________________________________________________________________________________________| |
RESPIRATORY SYSTEM | | |
|__________________________________________________________________________|____________|
Lung | + + + + + + + + + + | 10 |
Hemorrhage, Focal | 1 | 1 1.0|
Artery, Mineralization | 1 1 1 1 1 | 5 1.0|
Interstitium, Inflammation, Chronic, | | |
Multifocal | 1 | 1 1.0|
Vein, Mineralization | 1 | 1 1.0|
|__________________________________________________________________________|____________|
Nose | + + + + + + + + + + | 10 |
|__________________________________________________________________________|____________|
Trachea | + + + + + + + + + + | 10 |
_____________________________________________________________________________________________________________________| |
SPECIAL SENSES SYSTEM | | |
None | | |
_____________________________________________________________________________________________________________________| |
URINARY SYSTEM | | |
|__________________________________________________________________________|____________|
Kidney | + + + + + + + + + + | 10 |
Mineralization | 2 1 2 1 1 1 2 2 1 2 | 10 1.5|
Cortex, Pigmentation, Hemosiderin | 3 3 3 3 3 3 3 3 3 3 | 10 3.0|
|__________________________________________________________________________|____________|
Urinary Bladder | + + + + + + + + + + | 10 |
__________________________________________________________________________________________________________________________________
* : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade
+ : Tissue examined microscopically M : Missing tissue 1-4 : Lesion qualified as:
X : Lesion present but not qualified A : Autolysis precludes examination 1) Minimal 3) Moderate
I : Insufficient tissue BLANK : Not examined 2) Mild 4) Marked
Page 33
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