TDMS Study 61529-02 Pathology Tables
NTP Experiment-Test: 61529-02 INCIDENCE RATES OF NONNEOPLASTIC LESIONS BY ANATOMIC SITE (a) Report: PEIRPT03
Study Type: SUBCHRON 90-DAY M-CHLOROANILINE Date: 10/20/04
Route: GAVAGE Time: 11:11:45
Facility: Battelle Columbus Laboratory
Chemical CAS #: 108-42-09
Lock Date: 11/16/92
Cage Range: All
Reasons For Removal: All
Removal Date Range: All
Treatment Groups: Include All
a Number of animals examined microscopically at site and number of animals with lesion
Page 1
NTP Experiment-Test: 61529-02 INCIDENCE RATES OF NONNEOPLASTIC LESIONS BY ANATOMIC SITE (a) Report: PEIRPT03
Study Type: SUBCHRON 90-DAY M-CHLOROANILINE Date: 10/20/04
Route: GAVAGE Time: 11:11:45
____________________________________________________________________________________________________________________________________
B6C3F1 MICE FEMALE 0 MG/KG 10 MG/KG 20 MG/KG 40 MG/KG 80 MG/KG 160
MG/KG
____________________________________________________________________________________________________________________________________
DISPOSITION SUMMARY
Animals Initially In Study 10 10 10 10 10 10
Early Deaths
Dosing Accident 1 1 2 1
Survivors
Terminal Sacrifice 9 9 10 8 10 9
Animals Examined Microscopically 10 10 10 10 10 10
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ALIMENTARY SYSTEM
Esophagus (10) (1) (2) (10)
Hemorrhage 1 (10%)
Ulcer 1 (50%)
Liver (10) (1) (2) (9) (10)
Hematopoietic Cell Proliferation 1 (11%) 7 (70%)
Necrosis, Focal 1 (10%)
Kupffer Cell, Pigmentation 9 (100%) 9 (90%)
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CARDIOVASCULAR SYSTEM
Heart (10) (1) (2) (10)
Pericardium, Inflammation, Suppurative 1 (100%) 1 (50%)
____________________________________________________________________________________________________________________________________
ENDOCRINE SYSTEM
None
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GENERAL BODY SYSTEM
None
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GENITAL SYSTEM
Ovary (1) (1) (2)
Cyst 1 (100%)
____________________________________________________________________________________________________________________________________
a Number of animals examined microscopically at site and number of animals with lesion
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NTP Experiment-Test: 61529-02 INCIDENCE RATES OF NONNEOPLASTIC LESIONS BY ANATOMIC SITE (a) Report: PEIRPT03
Study Type: SUBCHRON 90-DAY M-CHLOROANILINE Date: 10/20/04
Route: GAVAGE Time: 11:11:45
____________________________________________________________________________________________________________________________________
B6C3F1 MICE FEMALE 0 MG/KG 10 MG/KG 20 MG/KG 40 MG/KG 80 MG/KG 160
MG/KG
____________________________________________________________________________________________________________________________________
HEMATOPOIETIC SYSTEM
Bone Marrow (10) (10) (10) (10) (10) (10)
Pigmentation, Hemosiderin 4 (40%) 8 (80%) 7 (70%) 10 (100%) 9 (90%)
Erythroid Cell, Hyperplasia 2 (20%)
Myeloid Cell, Hyperplasia, Diffuse 1 (10%)
Spleen (10) (10) (10) (10) (10) (10)
Hematopoietic Cell Proliferation 2 (20%) 7 (70%) 7 (70%) 10 (100%) 9 (90%)
Pigmentation, Hemosiderin 9 (90%) 10 (100%) 8 (80%) 10 (100%) 9 (90%)
Thymus (10) (1) (2) (10)
Atrophy 1 (50%)
____________________________________________________________________________________________________________________________________
INTEGUMENTARY SYSTEM
None
____________________________________________________________________________________________________________________________________
MUSCULOSKELETAL SYSTEM
None
____________________________________________________________________________________________________________________________________
NERVOUS SYSTEM
None
____________________________________________________________________________________________________________________________________
RESPIRATORY SYSTEM
Lung (10) (1) (2) (10)
Foreign Body 2 (100%) 1 (10%)
Hemorrhage 1 (10%)
Serosa, Inflammation, Suppurative 1 (100%) 2 (100%) 1 (10%)
____________________________________________________________________________________________________________________________________
SPECIAL SENSES SYSTEM
None
____________________________________________________________________________________________________________________________________
URINARY SYSTEM
Kidney (10) (1) (2) (10)
a Number of animals examined microscopically at site and number of animals with lesion
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NTP Experiment-Test: 61529-02 INCIDENCE RATES OF NONNEOPLASTIC LESIONS BY ANATOMIC SITE (a) Report: PEIRPT03
Study Type: SUBCHRON 90-DAY M-CHLOROANILINE Date: 10/20/04
Route: GAVAGE Time: 11:11:45
____________________________________________________________________________________________________________________________________
B6C3F1 MICE FEMALE 0 MG/KG 10 MG/KG 20 MG/KG 40 MG/KG 80 MG/KG 160
MG/KG
____________________________________________________________________________________________________________________________________
URINARY SYSTEM - CONT
Hyperplasia, Lymphoid 1 (10%)
Infarct 1 (10%)
Pigmentation 6 (60%)
a Number of animals examined microscopically at site and number of animals with lesion
Page 4
NTP Experiment-Test: 61529-02 INCIDENCE RATES OF NONNEOPLASTIC LESIONS BY ANATOMIC SITE (a) Report: PEIRPT03
Study Type: SUBCHRON 90-DAY M-CHLOROANILINE Date: 10/20/04
Route: GAVAGE Time: 11:11:45
____________________________________________________________________________________________________________________________________
B6C3F1 MICE MALE 0 MG/KG 10 MG/KG 20 MG/KG 40 MG/KG 80 MG/KG 160
MG/KG
____________________________________________________________________________________________________________________________________
DISPOSITION SUMMARY
Animals Initially In Study 10 10 10 10 10 10
Early Deaths
Dosing Accident 1 3
Survivors
Terminal Sacrifice 9 10 7 10 10 10
Animals Examined Microscopically 10 10 10 10 10 10
____________________________________________________________________________________________________________________________________
ALIMENTARY SYSTEM
Esophagus (10) (3) (10)
Foreign Body 1 (33%)
Inflammation, Suppurative 1 (10%)
Perforation 1 (10%)
Liver (10) (3) (3) (10)
Hematopoietic Cell Proliferation 8 (80%)
Kupffer Cell, Pigmentation 3 (100%) 9 (90%)
____________________________________________________________________________________________________________________________________
CARDIOVASCULAR SYSTEM
Heart (10) (3) (10)
Inflammation, Suppurative 2 (67%)
Myocardium, Degeneration 1 (10%)
Pericardium, Inflammation, Suppurative 1 (10%) 1 (33%)
____________________________________________________________________________________________________________________________________
ENDOCRINE SYSTEM
None
____________________________________________________________________________________________________________________________________
GENERAL BODY SYSTEM
None
____________________________________________________________________________________________________________________________________
GENITAL SYSTEM
None
____________________________________________________________________________________________________________________________________
a Number of animals examined microscopically at site and number of animals with lesion
Page 5
NTP Experiment-Test: 61529-02 INCIDENCE RATES OF NONNEOPLASTIC LESIONS BY ANATOMIC SITE (a) Report: PEIRPT03
Study Type: SUBCHRON 90-DAY M-CHLOROANILINE Date: 10/20/04
Route: GAVAGE Time: 11:11:45
____________________________________________________________________________________________________________________________________
B6C3F1 MICE MALE 0 MG/KG 10 MG/KG 20 MG/KG 40 MG/KG 80 MG/KG 160
MG/KG
____________________________________________________________________________________________________________________________________
HEMATOPOIETIC SYSTEM
Bone Marrow (10) (10) (10) (10) (10) (10)
Pigmentation, Hemosiderin 10 (100%) 10 (100%) 10 (100%)
Erythroid Cell, Hyperplasia 4 (40%)
Spleen (10) (10) (10) (10) (10) (10)
Hematopoietic Cell Proliferation 3 (30%) 10 (100%) 10 (100%) 10 (100%)
Pigmentation, Hemosiderin 1 (10%) 4 (40%) 10 (100%) 10 (100%) 10 (100%)
____________________________________________________________________________________________________________________________________
INTEGUMENTARY SYSTEM
None
____________________________________________________________________________________________________________________________________
MUSCULOSKELETAL SYSTEM
None
____________________________________________________________________________________________________________________________________
NERVOUS SYSTEM
None
____________________________________________________________________________________________________________________________________
RESPIRATORY SYSTEM
Lung (10) (3) (10)
Foreign Body 1 (10%) 1 (33%)
Serosa, Inflammation, Suppurative 1 (10%) 3 (100%)
____________________________________________________________________________________________________________________________________
SPECIAL SENSES SYSTEM
None
____________________________________________________________________________________________________________________________________
URINARY SYSTEM
None
a Number of animals examined microscopically at site and number of animals with lesion
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