TDMS Study 60855-02 Pathology Tables
NTP Experiment-Test: 60855-02 INCIDENCE RATES OF NONNEOPLASTIC LESIONS BY ANATOMIC SITE (a) Report: PEIRPT03
Study Type: 18-33 DAYS BETA-BROMO-BETA-NITROSTYRENE Date: 10/19/04
Route: GAVAGE Time: 14:16:34
Facility: BIORELIANCE
Chemical CAS #: 7166-19-0
Lock Date: 04/23/92
Cage Range: All
Reasons For Removal: All
Removal Date Range: All
Treatment Groups: Include All
a Number of animals examined microscopically at site and number of animals with lesion
Page 1
NTP Experiment-Test: 60855-02 INCIDENCE RATES OF NONNEOPLASTIC LESIONS BY ANATOMIC SITE (a) Report: PEIRPT03
Study Type: 18-33 DAYS BETA-BROMO-BETA-NITROSTYRENE Date: 10/19/04
Route: GAVAGE Time: 14:16:34
____________________________________________________________________________________________________________________________________
B6C3F1 MICE FEMALE CONTROL 0.037 0.075 0.150 0.300 0.600
G/KG G/KG G/KG G/KG G/KG
____________________________________________________________________________________________________________________________________
DISPOSITION SUMMARY
Animals Initially In Study 10 10 10 10 10 10
Early Deaths
Dosing Accident 1
Natural Death 6
Moribund Sacrifice 4
Survivors
Terminal Sacrifice 10 10 10 9 10
Animals Examined Microscopically 10 10 10 10 10 10
____________________________________________________________________________________________________________________________________
ALIMENTARY SYSTEM
Esophagus (10) (1) (10) (10)
Inflammation 1 (100%)
Gallbladder (8) (10) (10) (8) (7) (9)
Hemorrhage 1 (11%)
Inflammation 2 (29%) 7 (78%)
Necrosis 1 (14%) 2 (22%)
Intestine Large, Colon (10) (1) (10) (9)
Inflammation 1 (11%)
Intestine Large, Cecum (10) (10) (6)
Inflammation 1 (17%)
Liver (10) (1) (10) (10)
Depletion Glycogen 1 (100%) 9 (90%)
Inflammation 2 (20%)
Necrosis 1 (10%) 4 (40%)
Pancreas (10) (1) (10) (10)
Inflammation 1 (10%) 4 (40%)
Necrosis 1 (10%)
Salivary Glands (10) (1) (10) (10)
Atrophy 1 (10%)
Inflammation 1 (10%)
Stomach, Forestomach (10) (10) (10) (10) (10) (10)
Inflammation 8 (80%)
Necrosis 4 (40%)
Epithelium, Hyperkeratosis 2 (20%)
Epithelium, Hyperplasia 10 (100%)
Stomach, Glandular (10) (10) (10) (10)
Hemorrhage 1 (10%)
Inflammation 2 (20%)
Necrosis 1 (10%)
a Number of animals examined microscopically at site and number of animals with lesion
Page 2
NTP Experiment-Test: 60855-02 INCIDENCE RATES OF NONNEOPLASTIC LESIONS BY ANATOMIC SITE (a) Report: PEIRPT03
Study Type: 18-33 DAYS BETA-BROMO-BETA-NITROSTYRENE Date: 10/19/04
Route: GAVAGE Time: 14:16:34
____________________________________________________________________________________________________________________________________
B6C3F1 MICE FEMALE CONTROL 0.037 0.075 0.150 0.300 0.600
G/KG G/KG G/KG G/KG G/KG
____________________________________________________________________________________________________________________________________
CARDIOVASCULAR SYSTEM
None
____________________________________________________________________________________________________________________________________
ENDOCRINE SYSTEM
None
____________________________________________________________________________________________________________________________________
GENERAL BODY SYSTEM
None
____________________________________________________________________________________________________________________________________
GENITAL SYSTEM
Uterus (10) (1) (10) (10)
Hydrometra 1 (10%)
Inflammation 1 (10%)
____________________________________________________________________________________________________________________________________
HEMATOPOIETIC SYSTEM
Bone Marrow (10) (1) (10) (10)
Erythroid Cell, Depletion Cellular 5 (50%)
Lymph Node, Mandibular (10) (1) (10) (9)
Hemorrhage 1 (10%)
Necrosis 1 (11%)
Lymph Node, Mesenteric (10) (10) (9)
Atrophy 1 (11%)
Hyperplasia 1 (10%)
Necrosis 1 (11%)
Spleen (10) (2) (10) (10)
Atrophy 1 (10%)
Congestion 4 (40%)
Hematopoietic Cell Proliferation 2 (20%)
Inflammation 2 (20%)
Necrosis 1 (10%)
Pigmentation 1 (50%)
Thymus (9) (1) (10) (8)
Atrophy 2 (25%)
Necrosis 6 (75%)
a Number of animals examined microscopically at site and number of animals with lesion
Page 3
NTP Experiment-Test: 60855-02 INCIDENCE RATES OF NONNEOPLASTIC LESIONS BY ANATOMIC SITE (a) Report: PEIRPT03
Study Type: 18-33 DAYS BETA-BROMO-BETA-NITROSTYRENE Date: 10/19/04
Route: GAVAGE Time: 14:16:34
____________________________________________________________________________________________________________________________________
B6C3F1 MICE FEMALE CONTROL 0.037 0.075 0.150 0.300 0.600
G/KG G/KG G/KG G/KG G/KG
____________________________________________________________________________________________________________________________________
INTEGUMENTARY SYSTEM
None
____________________________________________________________________________________________________________________________________
MUSCULOSKELETAL SYSTEM
None
____________________________________________________________________________________________________________________________________
NERVOUS SYSTEM
None
____________________________________________________________________________________________________________________________________
RESPIRATORY SYSTEM
Lung (10) (1) (10) (10)
Congestion 1 (100%) 1 (10%)
Hemorrhage 2 (20%) 1 (10%)
Mediastinum, Foreign Body 1 (100%)
Mediastinum, Inflammation 1 (100%)
Serosa, Foreign Body 1 (100%)
Serosa, Inflammation 1 (100%)
Nose (10) (1) (10) (10)
Inflammation 1 (10%)
____________________________________________________________________________________________________________________________________
SPECIAL SENSES SYSTEM
None
____________________________________________________________________________________________________________________________________
URINARY SYSTEM
Kidney (10) (1) (10) (10)
Congestion 3 (30%)
Urinary Bladder (10) (1) (10) (10)
Hemorrhage 1 (10%)
a Number of animals examined microscopically at site and number of animals with lesion
Page 4
NTP Experiment-Test: 60855-02 INCIDENCE RATES OF NONNEOPLASTIC LESIONS BY ANATOMIC SITE (a) Report: PEIRPT03
Study Type: 18-33 DAYS BETA-BROMO-BETA-NITROSTYRENE Date: 10/19/04
Route: GAVAGE Time: 14:16:34
____________________________________________________________________________________________________________________________________
B6C3F1 MICE MALE CONTROL 0.037 0.075 0.150 0.300 0.600
G/KG G/KG G/KG G/KG G/KG
____________________________________________________________________________________________________________________________________
DISPOSITION SUMMARY
Animals Initially In Study 10 10 10 10 10 10
Early Deaths
Natural Death 1 4
Moribund Sacrifice 6
Survivors
Terminal Sacrifice 9 9 9 10 9
Accidently Killed 1 1 1
Animals Examined Microscopically 10 10 10 10 10 10
____________________________________________________________________________________________________________________________________
ALIMENTARY SYSTEM
Esophagus (10) (10) (9)
Inflammation 1 (10%) 1 (10%)
Gallbladder (9) (10) (10) (10) (8) (5)
Degeneration 1 (13%) 4 (80%)
Hemorrhage 1 (13%)
Inflammation 3 (38%) 5 (100%)
Intestine Small, Jejunum (10) (9) (10)
Hemorrhage 1 (10%)
Inflammation 4 (40%)
Peyer's Patch, Necrosis 1 (10%)
Liver (10) (10) (10)
Depletion Glycogen 1 (10%) 10 (100%)
Necrosis 2 (20%)
Pancreas (10) (10) (10)
Inflammation 6 (60%)
Necrosis 3 (30%)
Stomach, Forestomach (10) (10) (10) (10) (10) (10)
Inflammation 1 (10%)
Ulcer 2 (20%)
Epithelium, Hyperkeratosis 9 (90%)
Epithelium, Hyperplasia 9 (90%)
____________________________________________________________________________________________________________________________________
CARDIOVASCULAR SYSTEM
None
____________________________________________________________________________________________________________________________________
ENDOCRINE SYSTEM
a Number of animals examined microscopically at site and number of animals with lesion
Page 5
NTP Experiment-Test: 60855-02 INCIDENCE RATES OF NONNEOPLASTIC LESIONS BY ANATOMIC SITE (a) Report: PEIRPT03
Study Type: 18-33 DAYS BETA-BROMO-BETA-NITROSTYRENE Date: 10/19/04
Route: GAVAGE Time: 14:16:34
____________________________________________________________________________________________________________________________________
B6C3F1 MICE MALE CONTROL 0.037 0.075 0.150 0.300 0.600
G/KG G/KG G/KG G/KG G/KG
____________________________________________________________________________________________________________________________________
None
____________________________________________________________________________________________________________________________________
GENERAL BODY SYSTEM
None
____________________________________________________________________________________________________________________________________
GENITAL SYSTEM
Epididymis (10) (10) (10)
Granuloma Sperm 1 (10%)
Testes (10) (10) (10)
Degeneration 6 (60%)
____________________________________________________________________________________________________________________________________
HEMATOPOIETIC SYSTEM
Bone Marrow (10) (10) (10)
Erythroid Cell, Depletion Cellular 5 (50%)
Lymph Node, Mandibular (9) (7) (9)
Atrophy 2 (22%)
Necrosis 1 (11%)
Lymph Node, Mesenteric (10) (10) (10)
Atrophy 3 (30%)
Inflammation 1 (10%)
Necrosis 2 (20%)
Spleen (10) (10) (10)
Atrophy 6 (60%)
Congestion 3 (30%)
Lymphoid Follicle, Necrosis 1 (10%)
Thymus (10) (10) (10)
Atrophy 3 (30%)
Hemorrhage 1 (10%)
Necrosis 8 (80%)
____________________________________________________________________________________________________________________________________
INTEGUMENTARY SYSTEM
None
____________________________________________________________________________________________________________________________________
MUSCULOSKELETAL SYSTEM
a Number of animals examined microscopically at site and number of animals with lesion
Page 6
NTP Experiment-Test: 60855-02 INCIDENCE RATES OF NONNEOPLASTIC LESIONS BY ANATOMIC SITE (a) Report: PEIRPT03
Study Type: 18-33 DAYS BETA-BROMO-BETA-NITROSTYRENE Date: 10/19/04
Route: GAVAGE Time: 14:16:34
____________________________________________________________________________________________________________________________________
B6C3F1 MICE MALE CONTROL 0.037 0.075 0.150 0.300 0.600
G/KG G/KG G/KG G/KG G/KG
____________________________________________________________________________________________________________________________________
None
____________________________________________________________________________________________________________________________________
NERVOUS SYSTEM
None
____________________________________________________________________________________________________________________________________
RESPIRATORY SYSTEM
Lung (10) (10) (10)
Congestion 3 (30%)
Hemorrhage 1 (10%) 1 (10%)
Nose (10) (10) (10)
Inflammation 1 (10%)
____________________________________________________________________________________________________________________________________
SPECIAL SENSES SYSTEM
None
____________________________________________________________________________________________________________________________________
URINARY SYSTEM
Kidney (10) (10) (10)
Congestion 1 (10%) 5 (50%)
a Number of animals examined microscopically at site and number of animals with lesion
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