TDMS Study 60855-02 Pathology Tables
NTP STATISTICAL ANALYSIS OF NON-NEOPLASTIC LESIONS REPORT: PEIRPT10
LAB: BIORELIANCE BETA-BROMO-BETA-NITROSTYRENE DATE: 10/19/04
EXPERIMENT: 60855 TEST: 02 TIME: 14:17:54
TEST TYPE: 18-33 DAYS PAGE: 1
CONT: NO1-ES-15319 ROUTE: GAVAGE NTP C#: C60855
PATHOLOGIST: MISSING CAS: 7166-19-0
------------------------------------------------------------------------------------------------------------------------------------
REASONS FOR REMOVAL: ALL
REMOVAL DATE RANGE: ALL
TREATMENT GROUPS: INCLUDE ALL
NTP STATISTICAL ANALYSIS OF NON-NEOPLASTIC LESIONS REPORT: PEIRPT10
LAB: BIORELIANCE BETA-BROMO-BETA-NITROSTYRENE DATE: 10/19/04
EXPERIMENT: 60855 TEST: 02 TIME: 14:17:54
TEST TYPE: 18-33 DAYS
CONT: NO1-ES-15319 ROUTE: GAVAGE NTP C#: C60855
PATHOLOGIST: MISSING CAS: 7166-19-0
SUMMARY OF STATISTICALLY SIGNIFICANT (P<=.05) RESULTS
IN THE ANALYSIS OF BETA-BROMO-BETA-NITROSTYRENE
===============================================================
Male Mice
------------
Organ Morphology
----- ----------
Bone Marrow: Erythroid Cell Depletion Cellular
Gallbladder Degeneration
Inflammation
Intestine Small, Jejunum Inflammation
Kidney Congestion
Liver Depletion Glycogen
Necrosis
Lung Congestion
Lymph Node, Mandibular Atrophy
Lymph Node, Mesenteric Atrophy
Necrosis
Pancreas Inflammation
Necrosis
Spleen Atrophy
Congestion
Stomach, Forestomach Inflammation
Ulcer
Stomach, Forestomach: Epithelium Hyperkeratosis
Hyperplasia
Testes Degeneration
Thymus Atrophy
Necrosis
===============================================================
Female Mice
------------
Organ Morphology
----- ----------
Bone Marrow: Erythroid Cell Depletion Cellular
Gallbladder Inflammation
Necrosis
Kidney Congestion
Liver Depletion Glycogen
Inflammation
Necrosis
Lung Hemorrhage
Lymph Node, Mesenteric Atrophy
Pancreas Inflammation
Necrosis
Spleen Atrophy
Congestion
Hematopoietic Cell Proliferation
Inflammation
Stomach, Forestomach Inflammation
Necrosis
Stomach, Forestomach: Epithelium Hyperkeratosis
Hyperplasia
Stomach, Glandular Inflammation
Thymus Atrophy
NTP STATISTICAL ANALYSIS OF NON-NEOPLASTIC LESIONS REPORT: PEIRPT10
LAB: BIORELIANCE BETA-BROMO-BETA-NITROSTYRENE DATE: 10/19/04
EXPERIMENT: 60855 TEST: 02 TIME: 14:17:54
TEST TYPE: 18-33 DAYS
CONT: NO1-ES-15319 ROUTE: GAVAGE NTP C#: C60855
PATHOLOGIST: MISSING CAS: 7166-19-0
Necrosis
===============================================================
Date: 10/19/04 EXPERIMENT: 60855 TEST: 02 Page 1
Statistical Analysis of Non-neoplastic Lesions in Mice(B6C3F1) - BETA-BROMO-BETA-NITROSTYRENE
Terminal Sacrifice at 5 weeks
|=================================================================================================================================|
| | |
| | Males |
|Dose | CONTROL 0.037 0.075 0.150 0.300 0.600 |
| | G/KG G/KG G/KG G/KG G/KG |
|=================================================================================================================================|
| |
|Bone Marrow: Erythroid Cell |
| Depletion Cellular |
| |
| |
|---------------------------------------------------------------------------------------------------------------------------------|
|LESION RATES | |
|----------- | |
|OVERALL (a) | 0/10 (0%) 0/0 (0%) 0/0 (0%) 0/0 (0%) 0/10 (0%) 5/10 (50%) |
|POLY-3 RATE (b) | 0/10.00 0/0.00 0/0.00 0/0.00 0/9.01 5/5.00 |
|POLY-3 PERCENT (g) | 0.0% 0.0% 0.0% 0.0% 0.0% 100.0% |
|TERMINAL (d) | 0/10 (0%) 0/0 (0%) 0/0 (0%) 0/0 (0%) 0/9 (0%) 0/0 (0%) |
|FIRST INCIDENCE | --- --- --- --- --- 2 |
|-------------------| |
|STATISTICAL TESTS | |
|-------------------| |
|LIFE TABLE | P<0.001 ** (e) (e) (e) (e) P=0.022 * |
|POLY 3 | (e) (e) (e) (e) (e) P<0.001 ** |
|POLY 1.5 | (e) (e) (e) (e) (e) P<0.001 ** |
|POLY 6 | (e) (e) (e) (e) (e) P<0.001 ** |
|LOGISTIC REGRESSION| (e) (e) (e) (e) (e) (e) |
|COCH-ARM / FISHERS | P=0.003 ** (e) (e) (e) (e) P=0.016 * |
|ORDER RESTRICTED | (e) (e) (e) (e) (e) (e) |
|=================================================================================================================================|
| | |
| | Females |
|Dose | CONTROL 0.037 0.075 0.150 0.300 0.600 |
| | G/KG G/KG G/KG G/KG G/KG |
|=================================================================================================================================|
| |
|Bone Marrow: Erythroid Cell |
| Depletion Cellular |
| |
| |
|---------------------------------------------------------------------------------------------------------------------------------|
|LESION RATES | |
|----------- | |
|OVERALL (a) | 0/10 (0%) 0/0 (0%) 0/0 (0%) 0/1 (0%) 0/10 (0%) 5/10 (50%) |
|POLY-3 RATE (b) | 0/10.00 0/0.00 0/0.00 0/0.01 0/10.00 5/5.00 |
|POLY-3 PERCENT (g) | 0.0% 0.0% 0.0% 0.0% 0.0% 100.0% |
|TERMINAL (d) | 0/10 (0%) 0/0 (0%) 0/0 (0%) 0/0 (0%) 0/10 (0%) 0/0 (0%) |
|FIRST INCIDENCE | --- --- --- --- --- 4 |
|-------------------| |
|STATISTICAL TESTS | |
|-------------------| |
|LIFE TABLE | P<0.001 ** (e) (e) (e) (e) P<0.001 ** |
|POLY 3 | (e) (e) (e) (e) (e) P<0.001 ** |
|POLY 1.5 | (e) (e) (e) (e) (e) P<0.001 ** |
|POLY 6 | (e) (e) (e) (e) (e) P<0.001 ** |
|LOGISTIC REGRESSION| P=0.350 (e) (e) (e) (e) (e) |
|COCH-ARM / FISHERS | P=0.003 ** (e) (e) (e) (e) P=0.016 * |
|ORDER RESTRICTED | (e) (e) (e) (e) (e) (e) |
|=================================================================================================================================|
Date: 10/19/04 EXPERIMENT: 60855 TEST: 02 Page 2
Statistical Analysis of Non-neoplastic Lesions in Mice(B6C3F1) - BETA-BROMO-BETA-NITROSTYRENE
Terminal Sacrifice at 5 weeks
|=================================================================================================================================|
| | |
| | Males |
|Dose | CONTROL 0.037 0.075 0.150 0.300 0.600 |
| | G/KG G/KG G/KG G/KG G/KG |
|=================================================================================================================================|
| |
|Gallbladder |
| Degeneration |
| |
| |
|---------------------------------------------------------------------------------------------------------------------------------|
|LESION RATES | |
|----------- | |
|OVERALL (a) | 0/9 (0%) 0/10 (0%) 0/10 (0%) 0/10 (0%) 1/8 (13%) 4/5 (80%) |
|POLY-3 RATE (b) | 0/9.00 0/10.00 0/10.00 0/10.00 1/7.01 4/4.00 |
|POLY-3 PERCENT (g) | 0.0% 0.0% 0.0% 0.0% 14.3% 100.0% |
|TERMINAL (d) | 0/9 (0%) 0/10 (0%) 0/10 (0%) 0/10 (0%) 1/7 (14%) 0/0 (0%) |
|FIRST INCIDENCE | --- --- --- --- 29 (T) 2 |
|-------------------| |
|STATISTICAL TESTS | |
|-------------------| |
|LIFE TABLE | P<0.001 ** (e) (e) (e) P=0.450 P=0.005 ** |
|POLY 3 | P<0.001 ** (e) (e) (e) P=0.450 P<0.001 ** |
|POLY 1.5 | P<0.001 ** (e) (e) (e) P=0.452 P<0.001 ** |
|POLY 6 | P<0.001 ** (e) (e) (e) P=0.450 P<0.001 ** |
|LOGISTIC REGRESSION| P=0.111 (e) (e) (e) P=0.450 (e) |
|COCH-ARM / FISHERS | P<0.001 ** (e) (e) (e) P=0.471 P=0.005 ** |
|ORDER RESTRICTED | P<0.001 ** (e) (e) (e) (e) (e) |
|=================================================================================================================================|
| | |
| | Females |
|Dose | CONTROL 0.037 0.075 0.150 0.300 0.600 |
| | G/KG G/KG G/KG G/KG G/KG |
|=================================================================================================================================|
| |
|Gallbladder |
| Degeneration |
| |
| |
|---------------------------------------------------------------------------------------------------------------------------------|
|LESION RATES | |
|----------- | |
|OVERALL (a) | 0/8 (0%) 0/10 (0%) 0/10 (0%) 0/8 (0%) 0/7 (0%) 0/9 (0%) |
|POLY-3 RATE (b) | 0/8.00 0/10.00 0/10.00 0/8.00 0/7.00 0/0.01 |
|POLY-3 PERCENT (g) | 0.0% 0.0% 0.0% 0.0% 0.0% 0.0% |
|TERMINAL (d) | 0/8 (0%) 0/10 (0%) 0/10 (0%) 0/8 (0%) 0/7 (0%) 0/0 (0%) |
|FIRST INCIDENCE | --- --- --- --- --- --- |
|-------------------| |
|STATISTICAL TESTS | |
|-------------------| |
|LIFE TABLE | (e) (e) (e) (e) (e) (e) |
|POLY 3 | (e) (e) (e) (e) (e) (e) |
|POLY 1.5 | (e) (e) (e) (e) (e) (e) |
|POLY 6 | (e) (e) (e) (e) (e) (e) |
|LOGISTIC REGRESSION| (e) (e) (e) (e) (e) (e) |
|COCH-ARM / FISHERS | (e) (e) (e) (e) (e) (e) |
|ORDER RESTRICTED | (e) (e) (e) (e) (e) (e) |
|=================================================================================================================================|
Date: 10/19/04 EXPERIMENT: 60855 TEST: 02 Page 3
Statistical Analysis of Non-neoplastic Lesions in Mice(B6C3F1) - BETA-BROMO-BETA-NITROSTYRENE
Terminal Sacrifice at 5 weeks
|=================================================================================================================================|
| | |
| | Males |
|Dose | CONTROL 0.037 0.075 0.150 0.300 0.600 |
| | G/KG G/KG G/KG G/KG G/KG |
|=================================================================================================================================|
| |
|Gallbladder |
| Inflammation |
| |
| |
|---------------------------------------------------------------------------------------------------------------------------------|
|LESION RATES | |
|----------- | |
|OVERALL (a) | 0/9 (0%) 0/10 (0%) 0/10 (0%) 0/10 (0%) 3/8 (38%) 5/5 (100%) |
|POLY-3 RATE (b) | 0/9.00 0/10.00 0/10.00 0/10.00 3/8.00 5/5.00 |
|POLY-3 PERCENT (g) | 0.0% 0.0% 0.0% 0.0% 37.5% 100.0% |
|TERMINAL (d) | 0/9 (0%) 0/10 (0%) 0/10 (0%) 0/10 (0%) 2/7 (29%) 0/0 (0%) |
|FIRST INCIDENCE | --- --- --- --- 6 2 |
|-------------------| |
|STATISTICAL TESTS | |
|-------------------| |
|LIFE TABLE | P<0.001 ** (e) (e) (e) P=0.091 P<0.001 ** |
|POLY 3 | P<0.001 ** (e) (e) (e) P=0.067 P<0.001 ** |
|POLY 1.5 | P<0.001 ** (e) (e) (e) P=0.067 P<0.001 ** |
|POLY 6 | P<0.001 ** (e) (e) (e) P=0.067 P<0.001 ** |
|LOGISTIC REGRESSION| (e) (e) (e) (e) (e) (e) |
|COCH-ARM / FISHERS | P<0.001 ** (e) (e) (e) P=0.082 P<0.001 ** |
|ORDER RESTRICTED | P<0.001 ** (e) (e) (e) (e) (e) |
|=================================================================================================================================|
| | |
| | Females |
|Dose | CONTROL 0.037 0.075 0.150 0.300 0.600 |
| | G/KG G/KG G/KG G/KG G/KG |
|=================================================================================================================================|
| |
|Gallbladder |
| Inflammation |
| |
| |
|---------------------------------------------------------------------------------------------------------------------------------|
|LESION RATES | |
|----------- | |
|OVERALL (a) | 0/8 (0%) 0/10 (0%) 0/10 (0%) 0/8 (0%) 2/7 (29%) 7/9 (78%) |
|POLY-3 RATE (b) | 0/8.00 0/10.00 0/10.00 0/8.00 2/7.00 7/7.00 |
|POLY-3 PERCENT (g) | 0.0% 0.0% 0.0% 0.0% 28.6% 100.0% |
|TERMINAL (d) | 0/8 (0%) 0/10 (0%) 0/10 (0%) 0/8 (0%) 2/7 (29%) 0/0 (0%) |
|FIRST INCIDENCE | --- --- --- --- 29 (T) 2 |
|-------------------| |
|STATISTICAL TESTS | |
|-------------------| |
|LIFE TABLE | P<0.001 ** (e) (e) (e) P=0.202 P<0.001 ** |
|POLY 3 | P<0.001 ** (e) (e) (e) P=0.188 P<0.001 ** |
|POLY 1.5 | P<0.001 ** (e) (e) (e) P=0.188 P<0.001 ** |
|POLY 6 | P<0.001 ** (e) (e) (e) P=0.188 P<0.001 ** |
|LOGISTIC REGRESSION| P=0.020 * (e) (e) (e) P=0.202 (e) |
|COCH-ARM / FISHERS | P<0.001 ** (e) (e) (e) P=0.200 P=0.002 ** |
|ORDER RESTRICTED | P<0.001 ** (e) (e) (e) (e) (e) |
|=================================================================================================================================|
Date: 10/19/04 EXPERIMENT: 60855 TEST: 02 Page 4
Statistical Analysis of Non-neoplastic Lesions in Mice(B6C3F1) - BETA-BROMO-BETA-NITROSTYRENE
Terminal Sacrifice at 5 weeks
|=================================================================================================================================|
| | |
| | Males |
|Dose | CONTROL 0.037 0.075 0.150 0.300 0.600 |
| | G/KG G/KG G/KG G/KG G/KG |
|=================================================================================================================================|
| |
|Gallbladder |
| Necrosis |
| |
| |
|---------------------------------------------------------------------------------------------------------------------------------|
|LESION RATES | |
|----------- | |
|OVERALL (a) | 0/9 (0%) 0/10 (0%) 0/10 (0%) 0/10 (0%) 0/8 (0%) 0/5 (0%) |
|POLY-3 RATE (b) | 0/9.00 0/10.00 0/10.00 0/10.00 0/7.01 0/0.00 |
|POLY-3 PERCENT (g) | 0.0% 0.0% 0.0% 0.0% 0.0% 0.0% |
|TERMINAL (d) | 0/9 (0%) 0/10 (0%) 0/10 (0%) 0/10 (0%) 0/7 (0%) 0/0 (0%) |
|FIRST INCIDENCE | --- --- --- --- --- --- |
|-------------------| |
|STATISTICAL TESTS | |
|-------------------| |
|LIFE TABLE | (e) (e) (e) (e) (e) (e) |
|POLY 3 | (e) (e) (e) (e) (e) (e) |
|POLY 1.5 | (e) (e) (e) (e) (e) (e) |
|POLY 6 | (e) (e) (e) (e) (e) (e) |
|LOGISTIC REGRESSION| (e) (e) (e) (e) (e) (e) |
|COCH-ARM / FISHERS | (e) (e) (e) (e) (e) (e) |
|ORDER RESTRICTED | (e) (e) (e) (e) (e) (e) |
|=================================================================================================================================|
| | |
| | Females |
|Dose | CONTROL 0.037 0.075 0.150 0.300 0.600 |
| | G/KG G/KG G/KG G/KG G/KG |
|=================================================================================================================================|
| |
|Gallbladder |
| Necrosis |
| |
| |
|---------------------------------------------------------------------------------------------------------------------------------|
|LESION RATES | |
|----------- | |
|OVERALL (a) | 0/8 (0%) 0/10 (0%) 0/10 (0%) 0/8 (0%) 1/7 (14%) 2/9 (22%) |
|POLY-3 RATE (b) | 0/8.00 0/10.00 0/10.00 0/8.00 1/7.00 2/2.01 |
|POLY-3 PERCENT (g) | 0.0% 0.0% 0.0% 0.0% 14.3% 99.5% |
|TERMINAL (d) | 0/8 (0%) 0/10 (0%) 0/10 (0%) 0/8 (0%) 1/7 (14%) 0/0 (0%) |
|FIRST INCIDENCE | --- --- --- --- 29 (T) 4 |
|-------------------| |
|STATISTICAL TESTS | |
|-------------------| |
|LIFE TABLE | P<0.001 ** (e) (e) (e) P=0.473 P=0.097 |
|POLY 3 | P=0.018 * (e) (e) (e) P=0.473 P=0.042 * |
|POLY 1.5 | P=0.015 * (e) (e) (e) P=0.473 P=0.046 * |
|POLY 6 | P=0.018 * (e) (e) (e) P=0.473 P=0.042 * |
|LOGISTIC REGRESSION| P=0.211 (e) (e) (e) P=0.473 (e) |
|COCH-ARM / FISHERS | P=0.013 * (e) (e) (e) P=0.467 P=0.265 |
|ORDER RESTRICTED | P=0.002 ** (e) (e) (e) (e) (e) |
|=================================================================================================================================|
Date: 10/19/04 EXPERIMENT: 60855 TEST: 02 Page 5
Statistical Analysis of Non-neoplastic Lesions in Mice(B6C3F1) - BETA-BROMO-BETA-NITROSTYRENE
Terminal Sacrifice at 5 weeks
|=================================================================================================================================|
| | |
| | Males |
|Dose | CONTROL 0.037 0.075 0.150 0.300 0.600 |
| | G/KG G/KG G/KG G/KG G/KG |
|=================================================================================================================================|
| |
|Intestine Small, Jejunum |
| Inflammation |
| |
| |
|---------------------------------------------------------------------------------------------------------------------------------|
|LESION RATES | |
|----------- | |
|OVERALL (a) | 0/10 (0%) 0/0 (0%) 0/0 (0%) 0/0 (0%) 0/9 (0%) 4/10 (40%) |
|POLY-3 RATE (b) | 0/10.00 0/0.00 0/0.00 0/0.00 0/9.00 4/4.00 |
|POLY-3 PERCENT (g) | 0.0% 0.0% 0.0% 0.0% 0.0% 100.0% |
|TERMINAL (d) | 0/10 (0%) 0/0 (0%) 0/0 (0%) 0/0 (0%) 0/9 (0%) 0/0 (0%) |
|FIRST INCIDENCE | --- --- --- --- --- 2 |
|-------------------| |
|STATISTICAL TESTS | |
|-------------------| |
|LIFE TABLE | P<0.001 ** (e) (e) (e) (e) P=0.051 |
|POLY 3 | (e) (e) (e) (e) (e) P<0.001 ** |
|POLY 1.5 | (e) (e) (e) (e) (e) P<0.001 ** |
|POLY 6 | (e) (e) (e) (e) (e) P<0.001 ** |
|LOGISTIC REGRESSION| (e) (e) (e) (e) (e) (e) |
|COCH-ARM / FISHERS | P=0.012 * (e) (e) (e) (e) P=0.043 * |
|ORDER RESTRICTED | (e) (e) (e) (e) (e) (e) |
|=================================================================================================================================|
| | |
| | Females |
|Dose | CONTROL 0.037 0.075 0.150 0.300 0.600 |
| | G/KG G/KG G/KG G/KG G/KG |
|=================================================================================================================================|
| |
|Intestine Small, Jejunum |
| Inflammation |
| |
| |
|---------------------------------------------------------------------------------------------------------------------------------|
|LESION RATES | |
|----------- | |
|OVERALL (a) | 0/10 (0%) 0/0 (0%) 0/0 (0%) 0/0 (0%) 0/10 (0%) 0/9 (0%) |
|POLY-3 RATE (b) | 0/10.00 0/0.00 0/0.00 0/0.00 0/10.00 0/0.01 |
|POLY-3 PERCENT (g) | 0.0% 0.0% 0.0% 0.0% 0.0% 0.0% |
|TERMINAL (d) | 0/10 (0%) 0/0 (0%) 0/0 (0%) 0/0 (0%) 0/10 (0%) 0/0 (0%) |
|FIRST INCIDENCE | --- --- --- --- --- --- |
|-------------------| |
|STATISTICAL TESTS | |
|-------------------| |
|LIFE TABLE | (e) (e) (e) (e) (e) (e) |
|POLY 3 | (e) (e) (e) (e) (e) (e) |
|POLY 1.5 | (e) (e) (e) (e) (e) (e) |
|POLY 6 | (e) (e) (e) (e) (e) (e) |
|LOGISTIC REGRESSION| (e) (e) (e) (e) (e) (e) |
|COCH-ARM / FISHERS | (e) (e) (e) (e) (e) (e) |
|ORDER RESTRICTED | (e) (e) (e) (e) (e) (e) |
|=================================================================================================================================|
Date: 10/19/04 EXPERIMENT: 60855 TEST: 02 Page 6
Statistical Analysis of Non-neoplastic Lesions in Mice(B6C3F1) - BETA-BROMO-BETA-NITROSTYRENE
Terminal Sacrifice at 5 weeks
|=================================================================================================================================|
| | |
| | Males |
|Dose | CONTROL 0.037 0.075 0.150 0.300 0.600 |
| | G/KG G/KG G/KG G/KG G/KG |
|=================================================================================================================================|
| |
|Kidney |
| Congestion |
| |
| |
|---------------------------------------------------------------------------------------------------------------------------------|
|LESION RATES | |
|----------- | |
|OVERALL (a) | 0/10 (0%) 0/0 (0%) 0/0 (0%) 0/0 (0%) 1/10 (10%) 5/10 (50%) |
|POLY-3 RATE (b) | 0/10.00 0/0.00 0/0.00 0/0.00 1/10.00 5/5.00 |
|POLY-3 PERCENT (g) | 0.0% 0.0% 0.0% 0.0% 10.0% 100.0% |
|TERMINAL (d) | 0/10 (0%) 0/0 (0%) 0/0 (0%) 0/0 (0%) 0/9 (0%) 0/0 (0%) |
|FIRST INCIDENCE | --- --- --- --- 6 2 |
|-------------------| |
|STATISTICAL TESTS | |
|-------------------| |
|LIFE TABLE | P<0.001 ** (e) (e) (e) P=0.500 P=0.022 * |
|POLY 3 | (e) (e) (e) (e) P=0.500 P<0.001 ** |
|POLY 1.5 | (e) (e) (e) (e) P=0.500 P<0.001 ** |
|POLY 6 | (e) (e) (e) (e) P=0.500 P<0.001 ** |
|LOGISTIC REGRESSION| P=0.501N (e) (e) (e) (e) (e) |
|COCH-ARM / FISHERS | P=0.006 ** (e) (e) (e) P=0.500 P=0.016 * |
|ORDER RESTRICTED | (e) (e) (e) (e) (e) (e) |
|=================================================================================================================================|
| | |
| | Females |
|Dose | CONTROL 0.037 0.075 0.150 0.300 0.600 |
| | G/KG G/KG G/KG G/KG G/KG |
|=================================================================================================================================|
| |
|Kidney |
| Congestion |
| |
| |
|---------------------------------------------------------------------------------------------------------------------------------|
|LESION RATES | |
|----------- | |
|OVERALL (a) | 0/10 (0%) 0/0 (0%) 0/0 (0%) 0/1 (0%) 0/10 (0%) 3/10 (30%) |
|POLY-3 RATE (b) | 0/10.00 0/0.00 0/0.00 0/0.01 0/10.00 3/3.01 |
|POLY-3 PERCENT (g) | 0.0% 0.0% 0.0% 0.0% 0.0% 99.6% |
|TERMINAL (d) | 0/10 (0%) 0/0 (0%) 0/0 (0%) 0/0 (0%) 0/10 (0%) 0/0 (0%) |
|FIRST INCIDENCE | --- --- --- --- --- 2 |
|-------------------| |
|STATISTICAL TESTS | |
|-------------------| |
|LIFE TABLE | P<0.001 ** (e) (e) (e) (e) P=0.081 |
|POLY 3 | (e) (e) (e) (e) (e) P=0.003 ** |
|POLY 1.5 | (e) (e) (e) (e) (e) P=0.004 ** |
|POLY 6 | (e) (e) (e) (e) (e) P=0.003 ** |
|LOGISTIC REGRESSION| P=0.908 (e) (e) (e) (e) (e) |
|COCH-ARM / FISHERS | P=0.028 * (e) (e) (e) (e) P=0.105 |
|ORDER RESTRICTED | (e) (e) (e) (e) (e) (e) |
|=================================================================================================================================|
Date: 10/19/04 EXPERIMENT: 60855 TEST: 02 Page 7
Statistical Analysis of Non-neoplastic Lesions in Mice(B6C3F1) - BETA-BROMO-BETA-NITROSTYRENE
Terminal Sacrifice at 5 weeks
|=================================================================================================================================|
| | |
| | Males |
|Dose | CONTROL 0.037 0.075 0.150 0.300 0.600 |
| | G/KG G/KG G/KG G/KG G/KG |
|=================================================================================================================================|
| |
|Liver |
| Depletion Glycogen |
| |
| |
|---------------------------------------------------------------------------------------------------------------------------------|
|LESION RATES | |
|----------- | |
|OVERALL (a) | 0/10 (0%) 0/0 (0%) 0/0 (0%) 0/0 (0%) 1/10 (10%) 10/10 (100%) |
|POLY-3 RATE (b) | 0/10.00 0/0.00 0/0.00 0/0.00 1/10.00 10/10.00 |
|POLY-3 PERCENT (g) | 0.0% 0.0% 0.0% 0.0% 10.0% 100.0% |
|TERMINAL (d) | 0/10 (0%) 0/0 (0%) 0/0 (0%) 0/0 (0%) 0/9 (0%) 0/0 (0%) |
|FIRST INCIDENCE | --- --- --- --- 6 2 |
|-------------------| |
|STATISTICAL TESTS | |
|-------------------| |
|LIFE TABLE | P<0.001 ** (e) (e) (e) P=0.500 P<0.001 ** |
|POLY 3 | (e) (e) (e) (e) P=0.500 P<0.001 ** |
|POLY 1.5 | (e) (e) (e) (e) P=0.500 P<0.001 ** |
|POLY 6 | (e) (e) (e) (e) P=0.500 P<0.001 ** |
|LOGISTIC REGRESSION| (e) (e) (e) (e) (e) (e) |
|COCH-ARM / FISHERS | P<0.001 ** (e) (e) (e) P=0.500 P<0.001 ** |
|ORDER RESTRICTED | (e) (e) (e) (e) (e) (e) |
|=================================================================================================================================|
| | |
| | Females |
|Dose | CONTROL 0.037 0.075 0.150 0.300 0.600 |
| | G/KG G/KG G/KG G/KG G/KG |
|=================================================================================================================================|
| |
|Liver |
| Depletion Glycogen |
| |
| |
|---------------------------------------------------------------------------------------------------------------------------------|
|LESION RATES | |
|----------- | |
|OVERALL (a) | 0/10 (0%) 0/0 (0%) 0/0 (0%) 1/1 (100%) 0/10 (0%) 9/10 (90%) |
|POLY-3 RATE (b) | 0/10.00 0/0.00 0/0.00 1/1.00 0/10.00 9/9.00 |
|POLY-3 PERCENT (g) | 0.0% 0.0% 0.0% 100.0% 0.0% 100.0% |
|TERMINAL (d) | 0/10 (0%) 0/0 (0%) 0/0 (0%) 0/0 (0%) 0/10 (0%) 0/0 (0%) |
|FIRST INCIDENCE | --- --- --- 6 --- 2 |
|-------------------| |
|STATISTICAL TESTS | |
|-------------------| |
|LIFE TABLE | P<0.001 ** (e) (e) P=0.500 (e) P<0.001 ** |
|POLY 3 | (e) (e) (e) P=0.091 (e) P<0.001 ** |
|POLY 1.5 | (e) (e) (e) P=0.091 (e) P<0.001 ** |
|POLY 6 | (e) (e) (e) P=0.091 (e) P<0.001 ** |
|LOGISTIC REGRESSION| P=0.737N (e) (e) (e) (e) (e) |
|COCH-ARM / FISHERS | P<0.001 ** (e) (e) P=0.091 (e) P<0.001 ** |
|ORDER RESTRICTED | (e) (e) (e) (e) (e) (e) |
|=================================================================================================================================|
Date: 10/19/04 EXPERIMENT: 60855 TEST: 02 Page 8
Statistical Analysis of Non-neoplastic Lesions in Mice(B6C3F1) - BETA-BROMO-BETA-NITROSTYRENE
Terminal Sacrifice at 5 weeks
|=================================================================================================================================|
| | |
| | Males |
|Dose | CONTROL 0.037 0.075 0.150 0.300 0.600 |
| | G/KG G/KG G/KG G/KG G/KG |
|=================================================================================================================================|
| |
|Liver |
| Inflammation |
| |
| |
|---------------------------------------------------------------------------------------------------------------------------------|
|LESION RATES | |
|----------- | |
|OVERALL (a) | 0/10 (0%) 0/0 (0%) 0/0 (0%) 0/0 (0%) 0/10 (0%) 0/10 (0%) |
|POLY-3 RATE (b) | 0/10.00 0/0.00 0/0.00 0/0.00 0/9.01 0/0.00 |
|POLY-3 PERCENT (g) | 0.0% 0.0% 0.0% 0.0% 0.0% 0.0% |
|TERMINAL (d) | 0/10 (0%) 0/0 (0%) 0/0 (0%) 0/0 (0%) 0/9 (0%) 0/0 (0%) |
|FIRST INCIDENCE | --- --- --- --- --- --- |
|-------------------| |
|STATISTICAL TESTS | |
|-------------------| |
|LIFE TABLE | (e) (e) (e) (e) (e) (e) |
|POLY 3 | (e) (e) (e) (e) (e) (e) |
|POLY 1.5 | (e) (e) (e) (e) (e) (e) |
|POLY 6 | (e) (e) (e) (e) (e) (e) |
|LOGISTIC REGRESSION| (e) (e) (e) (e) (e) (e) |
|COCH-ARM / FISHERS | (e) (e) (e) (e) (e) (e) |
|ORDER RESTRICTED | (e) (e) (e) (e) (e) (e) |
|=================================================================================================================================|
| | |
| | Females |
|Dose | CONTROL 0.037 0.075 0.150 0.300 0.600 |
| | G/KG G/KG G/KG G/KG G/KG |
|=================================================================================================================================|
| |
|Liver |
| Inflammation |
| |
| |
|---------------------------------------------------------------------------------------------------------------------------------|
|LESION RATES | |
|----------- | |
|OVERALL (a) | 0/10 (0%) 0/0 (0%) 0/0 (0%) 0/1 (0%) 0/10 (0%) 2/10 (20%) |
|POLY-3 RATE (b) | 0/10.00 0/0.00 0/0.00 0/0.01 0/10.00 2/2.01 |
|POLY-3 PERCENT (g) | 0.0% 0.0% 0.0% 0.0% 0.0% 99.4% |
|TERMINAL (d) | 0/10 (0%) 0/0 (0%) 0/0 (0%) 0/0 (0%) 0/10 (0%) 0/0 (0%) |
|FIRST INCIDENCE | --- --- --- --- --- 2 |
|-------------------| |
|STATISTICAL TESTS | |
|-------------------| |
|LIFE TABLE | P=0.005 ** (e) (e) (e) (e) P=0.166 |
|POLY 3 | (e) (e) (e) (e) (e) P=0.040 * |
|POLY 1.5 | (e) (e) (e) (e) (e) P=0.044 * |
|POLY 6 | (e) (e) (e) (e) (e) P=0.040 * |
|LOGISTIC REGRESSION| P=0.831 (e) (e) (e) (e) (e) |
|COCH-ARM / FISHERS | P=0.083 (e) (e) (e) (e) P=0.237 |
|ORDER RESTRICTED | (e) (e) (e) (e) (e) (e) |
|=================================================================================================================================|
Date: 10/19/04 EXPERIMENT: 60855 TEST: 02 Page 9
Statistical Analysis of Non-neoplastic Lesions in Mice(B6C3F1) - BETA-BROMO-BETA-NITROSTYRENE
Terminal Sacrifice at 5 weeks
|=================================================================================================================================|
| | |
| | Males |
|Dose | CONTROL 0.037 0.075 0.150 0.300 0.600 |
| | G/KG G/KG G/KG G/KG G/KG |
|=================================================================================================================================|
| |
|Liver |
| Necrosis |
| |
| |
|---------------------------------------------------------------------------------------------------------------------------------|
|LESION RATES | |
|----------- | |
|OVERALL (a) | 0/10 (0%) 0/0 (0%) 0/0 (0%) 0/0 (0%) 0/10 (0%) 2/10 (20%) |
|POLY-3 RATE (b) | 0/10.00 0/0.00 0/0.00 0/0.00 0/9.01 2/2.00 |
|POLY-3 PERCENT (g) | 0.0% 0.0% 0.0% 0.0% 0.0% 99.9% |
|TERMINAL (d) | 0/10 (0%) 0/0 (0%) 0/0 (0%) 0/0 (0%) 0/9 (0%) 0/0 (0%) |
|FIRST INCIDENCE | --- --- --- --- --- 2 |
|-------------------| |
|STATISTICAL TESTS | |
|-------------------| |
|LIFE TABLE | P=0.011 * (e) (e) (e) (e) P=0.234 |
|POLY 3 | (e) (e) (e) (e) (e) P=0.040 * |
|POLY 1.5 | (e) (e) (e) (e) (e) P=0.042 * |
|POLY 6 | (e) (e) (e) (e) (e) P=0.040 * |
|LOGISTIC REGRESSION| (e) (e) (e) (e) (e) (e) |
|COCH-ARM / FISHERS | P=0.089 (e) (e) (e) (e) P=0.237 |
|ORDER RESTRICTED | (e) (e) (e) (e) (e) (e) |
|=================================================================================================================================|
| | |
| | Females |
|Dose | CONTROL 0.037 0.075 0.150 0.300 0.600 |
| | G/KG G/KG G/KG G/KG G/KG |
|=================================================================================================================================|
| |
|Liver |
| Necrosis |
| |
| |
|---------------------------------------------------------------------------------------------------------------------------------|
|LESION RATES | |
|----------- | |
|OVERALL (a) | 0/10 (0%) 0/0 (0%) 0/0 (0%) 0/1 (0%) 1/10 (10%) 4/10 (40%) |
|POLY-3 RATE (b) | 0/10.00 0/0.00 0/0.00 0/0.01 1/10.00 4/4.00 |
|POLY-3 PERCENT (g) | 0.0% 0.0% 0.0% 0.0% 10.0% 99.9% |
|TERMINAL (d) | 0/10 (0%) 0/0 (0%) 0/0 (0%) 0/0 (0%) 1/10 (10%) 0/0 (0%) |
|FIRST INCIDENCE | --- --- --- --- 29 (T) 4 |
|-------------------| |
|STATISTICAL TESTS | |
|-------------------| |
|LIFE TABLE | P<0.001 ** (e) (e) (e) P=0.500 P=0.005 ** |
|POLY 3 | (e) (e) (e) (e) P=0.500 P<0.001 ** |
|POLY 1.5 | (e) (e) (e) (e) P=0.500 P<0.001 ** |
|POLY 6 | (e) (e) (e) (e) P=0.500 P<0.001 ** |
|LOGISTIC REGRESSION| P=0.207 (e) (e) (e) P=0.500 (e) |
|COCH-ARM / FISHERS | P=0.015 * (e) (e) (e) P=0.500 P=0.043 * |
|ORDER RESTRICTED | (e) (e) (e) (e) (e) (e) |
|=================================================================================================================================|
Date: 10/19/04 EXPERIMENT: 60855 TEST: 02 Page 10
Statistical Analysis of Non-neoplastic Lesions in Mice(B6C3F1) - BETA-BROMO-BETA-NITROSTYRENE
Terminal Sacrifice at 5 weeks
|=================================================================================================================================|
| | |
| | Males |
|Dose | CONTROL 0.037 0.075 0.150 0.300 0.600 |
| | G/KG G/KG G/KG G/KG G/KG |
|=================================================================================================================================|
| |
|Lung |
| Congestion |
| |
| |
|---------------------------------------------------------------------------------------------------------------------------------|
|LESION RATES | |
|----------- | |
|OVERALL (a) | 0/10 (0%) 0/0 (0%) 0/0 (0%) 0/0 (0%) 0/10 (0%) 3/10 (30%) |
|POLY-3 RATE (b) | 0/10.00 0/0.00 0/0.00 0/0.00 0/9.01 3/3.00 |
|POLY-3 PERCENT (g) | 0.0% 0.0% 0.0% 0.0% 0.0% 99.9% |
|TERMINAL (d) | 0/10 (0%) 0/0 (0%) 0/0 (0%) 0/0 (0%) 0/9 (0%) 0/0 (0%) |
|FIRST INCIDENCE | --- --- --- --- --- 2 |
|-------------------| |
|STATISTICAL TESTS | |
|-------------------| |
|LIFE TABLE | P<0.001 ** (e) (e) (e) (e) P=0.111 |
|POLY 3 | (e) (e) (e) (e) (e) P=0.003 ** |
|POLY 1.5 | (e) (e) (e) (e) (e) P=0.004 ** |
|POLY 6 | (e) (e) (e) (e) (e) P=0.003 ** |
|LOGISTIC REGRESSION| (e) (e) (e) (e) (e) (e) |
|COCH-ARM / FISHERS | P=0.031 * (e) (e) (e) (e) P=0.105 |
|ORDER RESTRICTED | (e) (e) (e) (e) (e) (e) |
|=================================================================================================================================|
| | |
| | Females |
|Dose | CONTROL 0.037 0.075 0.150 0.300 0.600 |
| | G/KG G/KG G/KG G/KG G/KG |
|=================================================================================================================================|
| |
|Lung |
| Congestion |
| |
| |
|---------------------------------------------------------------------------------------------------------------------------------|
|LESION RATES | |
|----------- | |
|OVERALL (a) | 0/10 (0%) 0/0 (0%) 0/0 (0%) 1/1 (100%) 0/10 (0%) 1/10 (10%) |
|POLY-3 RATE (b) | 0/10.00 0/0.00 0/0.00 1/1.00 0/10.00 1/1.01 |
|POLY-3 PERCENT (g) | 0.0% 0.0% 0.0% 100.0% 0.0% 98.8% |
|TERMINAL (d) | 0/10 (0%) 0/0 (0%) 0/0 (0%) 0/0 (0%) 0/10 (0%) 0/0 (0%) |
|FIRST INCIDENCE | --- --- --- 6 --- 4 |
|-------------------| |
|STATISTICAL TESTS | |
|-------------------| |
|LIFE TABLE | P=0.051 (e) (e) P=0.500 (e) P=0.362 |
|POLY 3 | (e) (e) (e) P=0.091 (e) P=0.243 |
|POLY 1.5 | (e) (e) (e) P=0.091 (e) P=0.252 |
|POLY 6 | (e) (e) (e) P=0.091 (e) P=0.243 |
|LOGISTIC REGRESSION| P=0.102N (e) (e) (e) (e) (e) |
|COCH-ARM / FISHERS | P=0.488 (e) (e) P=0.091 (e) P=0.500 |
|ORDER RESTRICTED | (e) (e) (e) (e) (e) (e) |
|=================================================================================================================================|
Date: 10/19/04 EXPERIMENT: 60855 TEST: 02 Page 11
Statistical Analysis of Non-neoplastic Lesions in Mice(B6C3F1) - BETA-BROMO-BETA-NITROSTYRENE
Terminal Sacrifice at 5 weeks
|=================================================================================================================================|
| | |
| | Males |
|Dose | CONTROL 0.037 0.075 0.150 0.300 0.600 |
| | G/KG G/KG G/KG G/KG G/KG |
|=================================================================================================================================|
| |
|Lung |
| Hemorrhage |
| |
| |
|---------------------------------------------------------------------------------------------------------------------------------|
|LESION RATES | |
|----------- | |
|OVERALL (a) | 1/10 (10%) 0/0 (0%) 0/0 (0%) 0/0 (0%) 0/10 (0%) 1/10 (10%) |
|POLY-3 RATE (b) | 1/10.00 0/0.00 0/0.00 0/0.00 0/9.01 1/1.00 |
|POLY-3 PERCENT (g) | 10.0% 0.0% 0.0% 0.0% 0.0% 99.7% |
|TERMINAL (d) | 1/10 (10%) 0/0 (0%) 0/0 (0%) 0/0 (0%) 0/9 (0%) 0/0 (0%) |
|FIRST INCIDENCE | 29 (T) --- --- --- --- 2 |
|-------------------| |
|STATISTICAL TESTS | |
|-------------------| |
|LIFE TABLE | P=0.327 P=1.000N P=1.000N P=1.000N P=0.521N P=0.500 |
|POLY 3 | (e) (e) (e) (e) P=0.521N P=0.352 |
|POLY 1.5 | (e) (e) (e) (e) P=0.519N P=0.362 |
|POLY 6 | (e) (e) (e) (e) P=0.521N P=0.352 |
|LOGISTIC REGRESSION| P=0.570N (e) (e) (e) (e) (e) |
|COCH-ARM / FISHERS | P=0.673 P=1.000 P=1.000 P=1.000 P=0.500N P=0.763N |
|ORDER RESTRICTED | (e) (e) (e) (e) (e) (e) |
|=================================================================================================================================|
| | |
| | Females |
|Dose | CONTROL 0.037 0.075 0.150 0.300 0.600 |
| | G/KG G/KG G/KG G/KG G/KG |
|=================================================================================================================================|
| |
|Lung |
| Hemorrhage |
| |
| |
|---------------------------------------------------------------------------------------------------------------------------------|
|LESION RATES | |
|----------- | |
|OVERALL (a) | 0/10 (0%) 0/0 (0%) 0/0 (0%) 0/1 (0%) 2/10 (20%) 1/10 (10%) |
|POLY-3 RATE (b) | 0/10.00 0/0.00 0/0.00 0/0.01 2/10.00 1/1.01 |
|POLY-3 PERCENT (g) | 0.0% 0.0% 0.0% 0.0% 20.0% 98.8% |
|TERMINAL (d) | 0/10 (0%) 0/0 (0%) 0/0 (0%) 0/0 (0%) 2/10 (20%) 0/0 (0%) |
|FIRST INCIDENCE | --- --- --- --- 29 (T) 4 |
|-------------------| |
|STATISTICAL TESTS | |
|-------------------| |
|LIFE TABLE | P=0.014 * (e) (e) (e) P=0.234 P=0.362 |
|POLY 3 | (e) (e) (e) (e) P=0.227 P=0.243 |
|POLY 1.5 | (e) (e) (e) (e) P=0.227 P=0.252 |
|POLY 6 | (e) (e) (e) (e) P=0.227 P=0.243 |
|LOGISTIC REGRESSION| P=0.189 (e) (e) (e) P=0.234 (e) |
|COCH-ARM / FISHERS | P=0.340 (e) (e) (e) P=0.237 P=0.500 |
|ORDER RESTRICTED | (e) (e) (e) (e) (e) (e) |
|=================================================================================================================================|
Date: 10/19/04 EXPERIMENT: 60855 TEST: 02 Page 12
Statistical Analysis of Non-neoplastic Lesions in Mice(B6C3F1) - BETA-BROMO-BETA-NITROSTYRENE
Terminal Sacrifice at 5 weeks
|=================================================================================================================================|
| | |
| | Males |
|Dose | CONTROL 0.037 0.075 0.150 0.300 0.600 |
| | G/KG G/KG G/KG G/KG G/KG |
|=================================================================================================================================|
| |
|Lymph Node, Mandibular |
| Atrophy |
| |
| |
|---------------------------------------------------------------------------------------------------------------------------------|
|LESION RATES | |
|----------- | |
|OVERALL (a) | 0/9 (0%) 0/0 (0%) 0/0 (0%) 0/0 (0%) 0/7 (0%) 2/9 (22%) |
|POLY-3 RATE (b) | 0/9.00 0/0.00 0/0.00 0/0.00 0/7.00 2/2.00 |
|POLY-3 PERCENT (g) | 0.0% 0.0% 0.0% 0.0% 0.0% 99.9% |
|TERMINAL (d) | 0/9 (0%) 0/0 (0%) 0/0 (0%) 0/0 (0%) 0/7 (0%) 0/0 (0%) |
|FIRST INCIDENCE | --- --- --- --- --- 2 |
|-------------------| |
|STATISTICAL TESTS | |
|-------------------| |
|LIFE TABLE | P=0.008 ** (e) (e) (e) (e) P=0.210 |
|POLY 3 | (e) (e) (e) (e) (e) P=0.038 * |
|POLY 1.5 | (e) (e) (e) (e) (e) P=0.040 * |
|POLY 6 | (e) (e) (e) (e) (e) P=0.038 * |
|LOGISTIC REGRESSION| (e) (e) (e) (e) (e) (e) |
|COCH-ARM / FISHERS | P=0.096 (e) (e) (e) (e) P=0.235 |
|ORDER RESTRICTED | (e) (e) (e) (e) (e) (e) |
|=================================================================================================================================|
| | |
| | Females |
|Dose | CONTROL 0.037 0.075 0.150 0.300 0.600 |
| | G/KG G/KG G/KG G/KG G/KG |
|=================================================================================================================================|
| |
|Lymph Node, Mandibular |
| Atrophy |
| |
| |
|---------------------------------------------------------------------------------------------------------------------------------|
|LESION RATES | |
|----------- | |
|OVERALL (a) | 0/10 (0%) 0/0 (0%) 0/0 (0%) 0/1 (0%) 0/10 (0%) 0/9 (0%) |
|POLY-3 RATE (b) | 0/10.00 0/0.00 0/0.00 0/0.01 0/10.00 0/0.01 |
|POLY-3 PERCENT (g) | 0.0% 0.0% 0.0% 0.0% 0.0% 0.0% |
|TERMINAL (d) | 0/10 (0%) 0/0 (0%) 0/0 (0%) 0/0 (0%) 0/10 (0%) 0/0 (0%) |
|FIRST INCIDENCE | --- --- --- --- --- --- |
|-------------------| |
|STATISTICAL TESTS | |
|-------------------| |
|LIFE TABLE | (e) (e) (e) (e) (e) (e) |
|POLY 3 | (e) (e) (e) (e) (e) (e) |
|POLY 1.5 | (e) (e) (e) (e) (e) (e) |
|POLY 6 | (e) (e) (e) (e) (e) (e) |
|LOGISTIC REGRESSION| (e) (e) (e) (e) (e) (e) |
|COCH-ARM / FISHERS | (e) (e) (e) (e) (e) (e) |
|ORDER RESTRICTED | (e) (e) (e) (e) (e) (e) |
|=================================================================================================================================|
Date: 10/19/04 EXPERIMENT: 60855 TEST: 02 Page 13
Statistical Analysis of Non-neoplastic Lesions in Mice(B6C3F1) - BETA-BROMO-BETA-NITROSTYRENE
Terminal Sacrifice at 5 weeks
|=================================================================================================================================|
| | |
| | Males |
|Dose | CONTROL 0.037 0.075 0.150 0.300 0.600 |
| | G/KG G/KG G/KG G/KG G/KG |
|=================================================================================================================================|
| |
|Lymph Node, Mesenteric |
| Atrophy |
| |
| |
|---------------------------------------------------------------------------------------------------------------------------------|
|LESION RATES | |
|----------- | |
|OVERALL (a) | 0/10 (0%) 0/0 (0%) 0/0 (0%) 0/0 (0%) 0/10 (0%) 3/10 (30%) |
|POLY-3 RATE (b) | 0/10.00 0/0.00 0/0.00 0/0.00 0/9.01 3/3.00 |
|POLY-3 PERCENT (g) | 0.0% 0.0% 0.0% 0.0% 0.0% 99.9% |
|TERMINAL (d) | 0/10 (0%) 0/0 (0%) 0/0 (0%) 0/0 (0%) 0/9 (0%) 0/0 (0%) |
|FIRST INCIDENCE | --- --- --- --- --- 2 |
|-------------------| |
|STATISTICAL TESTS | |
|-------------------| |
|LIFE TABLE | P<0.001 ** (e) (e) (e) (e) P=0.111 |
|POLY 3 | (e) (e) (e) (e) (e) P=0.003 ** |
|POLY 1.5 | (e) (e) (e) (e) (e) P=0.004 ** |
|POLY 6 | (e) (e) (e) (e) (e) P=0.003 ** |
|LOGISTIC REGRESSION| (e) (e) (e) (e) (e) (e) |
|COCH-ARM / FISHERS | P=0.031 * (e) (e) (e) (e) P=0.105 |
|ORDER RESTRICTED | (e) (e) (e) (e) (e) (e) |
|=================================================================================================================================|
| | |
| | Females |
|Dose | CONTROL 0.037 0.075 0.150 0.300 0.600 |
| | G/KG G/KG G/KG G/KG G/KG |
|=================================================================================================================================|
| |
|Lymph Node, Mesenteric |
| Atrophy |
| |
| |
|---------------------------------------------------------------------------------------------------------------------------------|
|LESION RATES | |
|----------- | |
|OVERALL (a) | 0/10 (0%) 0/0 (0%) 0/0 (0%) 0/0 (0%) 0/10 (0%) 1/9 (11%) |
|POLY-3 RATE (b) | 0/10.00 0/0.00 0/0.00 0/0.00 0/10.00 1/1.01 |
|POLY-3 PERCENT (g) | 0.0% 0.0% 0.0% 0.0% 0.0% 98.8% |
|TERMINAL (d) | 0/10 (0%) 0/0 (0%) 0/0 (0%) 0/0 (0%) 0/10 (0%) 0/0 (0%) |
|FIRST INCIDENCE | --- --- --- --- --- 4 |
|-------------------| |
|STATISTICAL TESTS | |
|-------------------| |
|LIFE TABLE | P=0.046 * (e) (e) (e) (e) P=0.362 |
|POLY 3 | (e) (e) (e) (e) (e) P=0.237 |
|POLY 1.5 | (e) (e) (e) (e) (e) P=0.245 |
|POLY 6 | (e) (e) (e) (e) (e) P=0.237 |
|LOGISTIC REGRESSION| (e) (e) (e) (e) (e) (e) |
|COCH-ARM / FISHERS | P=0.251 (e) (e) (e) (e) P=0.474 |
|ORDER RESTRICTED | (e) (e) (e) (e) (e) (e) |
|=================================================================================================================================|
Date: 10/19/04 EXPERIMENT: 60855 TEST: 02 Page 14
Statistical Analysis of Non-neoplastic Lesions in Mice(B6C3F1) - BETA-BROMO-BETA-NITROSTYRENE
Terminal Sacrifice at 5 weeks
|=================================================================================================================================|
| | |
| | Males |
|Dose | CONTROL 0.037 0.075 0.150 0.300 0.600 |
| | G/KG G/KG G/KG G/KG G/KG |
|=================================================================================================================================|
| |
|Lymph Node, Mesenteric |
| Necrosis |
| |
| |
|---------------------------------------------------------------------------------------------------------------------------------|
|LESION RATES | |
|----------- | |
|OVERALL (a) | 0/10 (0%) 0/0 (0%) 0/0 (0%) 0/0 (0%) 0/10 (0%) 2/10 (20%) |
|POLY-3 RATE (b) | 0/10.00 0/0.00 0/0.00 0/0.00 0/9.01 2/2.00 |
|POLY-3 PERCENT (g) | 0.0% 0.0% 0.0% 0.0% 0.0% 99.9% |
|TERMINAL (d) | 0/10 (0%) 0/0 (0%) 0/0 (0%) 0/0 (0%) 0/9 (0%) 0/0 (0%) |
|FIRST INCIDENCE | --- --- --- --- --- 2 |
|-------------------| |
|STATISTICAL TESTS | |
|-------------------| |
|LIFE TABLE | P=0.011 * (e) (e) (e) (e) P=0.234 |
|POLY 3 | (e) (e) (e) (e) (e) P=0.040 * |
|POLY 1.5 | (e) (e) (e) (e) (e) P=0.042 * |
|POLY 6 | (e) (e) (e) (e) (e) P=0.040 * |
|LOGISTIC REGRESSION| (e) (e) (e) (e) (e) (e) |
|COCH-ARM / FISHERS | P=0.089 (e) (e) (e) (e) P=0.237 |
|ORDER RESTRICTED | (e) (e) (e) (e) (e) (e) |
|=================================================================================================================================|
| | |
| | Females |
|Dose | CONTROL 0.037 0.075 0.150 0.300 0.600 |
| | G/KG G/KG G/KG G/KG G/KG |
|=================================================================================================================================|
| |
|Lymph Node, Mesenteric |
| Necrosis |
| |
| |
|---------------------------------------------------------------------------------------------------------------------------------|
|LESION RATES | |
|----------- | |
|OVERALL (a) | 0/10 (0%) 0/0 (0%) 0/0 (0%) 0/0 (0%) 0/10 (0%) 1/9 (11%) |
|POLY-3 RATE (b) | 0/10.00 0/0.00 0/0.00 0/0.00 0/10.00 1/1.01 |
|POLY-3 PERCENT (g) | 0.0% 0.0% 0.0% 0.0% 0.0% 98.6% |
|TERMINAL (d) | 0/10 (0%) 0/0 (0%) 0/0 (0%) 0/0 (0%) 0/10 (0%) 0/0 (0%) |
|FIRST INCIDENCE | --- --- --- --- --- 2 |
|-------------------| |
|STATISTICAL TESTS | |
|-------------------| |
|LIFE TABLE | P=0.095 (e) (e) (e) (e) P=0.479 |
|POLY 3 | (e) (e) (e) (e) (e) P=0.237 |
|POLY 1.5 | (e) (e) (e) (e) (e) P=0.246 |
|POLY 6 | (e) (e) (e) (e) (e) P=0.237 |
|LOGISTIC REGRESSION| (e) (e) (e) (e) (e) (e) |
|COCH-ARM / FISHERS | P=0.251 (e) (e) (e) (e) P=0.474 |
|ORDER RESTRICTED | (e) (e) (e) (e) (e) (e) |
|=================================================================================================================================|
Date: 10/19/04 EXPERIMENT: 60855 TEST: 02 Page 15
Statistical Analysis of Non-neoplastic Lesions in Mice(B6C3F1) - BETA-BROMO-BETA-NITROSTYRENE
Terminal Sacrifice at 5 weeks
|=================================================================================================================================|
| | |
| | Males |
|Dose | CONTROL 0.037 0.075 0.150 0.300 0.600 |
| | G/KG G/KG G/KG G/KG G/KG |
|=================================================================================================================================|
| |
|Pancreas |
| Inflammation |
| |
| |
|---------------------------------------------------------------------------------------------------------------------------------|
|LESION RATES | |
|----------- | |
|OVERALL (a) | 0/10 (0%) 0/0 (0%) 0/0 (0%) 0/0 (0%) 0/10 (0%) 6/10 (60%) |
|POLY-3 RATE (b) | 0/10.00 0/0.00 0/0.00 0/0.00 0/9.01 6/6.00 |
|POLY-3 PERCENT (g) | 0.0% 0.0% 0.0% 0.0% 0.0% 100.0% |
|TERMINAL (d) | 0/10 (0%) 0/0 (0%) 0/0 (0%) 0/0 (0%) 0/9 (0%) 0/0 (0%) |
|FIRST INCIDENCE | --- --- --- --- --- 2 |
|-------------------| |
|STATISTICAL TESTS | |
|-------------------| |
|LIFE TABLE | P<0.001 ** (e) (e) (e) (e) P=0.009 ** |
|POLY 3 | (e) (e) (e) (e) (e) P<0.001 ** |
|POLY 1.5 | (e) (e) (e) (e) (e) P<0.001 ** |
|POLY 6 | (e) (e) (e) (e) (e) P<0.001 ** |
|LOGISTIC REGRESSION| (e) (e) (e) (e) (e) (e) |
|COCH-ARM / FISHERS | P<0.001 ** (e) (e) (e) (e) P=0.005 ** |
|ORDER RESTRICTED | (e) (e) (e) (e) (e) (e) |
|=================================================================================================================================|
| | |
| | Females |
|Dose | CONTROL 0.037 0.075 0.150 0.300 0.600 |
| | G/KG G/KG G/KG G/KG G/KG |
|=================================================================================================================================|
| |
|Pancreas |
| Inflammation |
| |
| |
|---------------------------------------------------------------------------------------------------------------------------------|
|LESION RATES | |
|----------- | |
|OVERALL (a) | 0/10 (0%) 0/0 (0%) 0/0 (0%) 0/1 (0%) 1/10 (10%) 4/10 (40%) |
|POLY-3 RATE (b) | 0/10.00 0/0.00 0/0.00 0/0.01 1/10.00 4/4.00 |
|POLY-3 PERCENT (g) | 0.0% 0.0% 0.0% 0.0% 10.0% 99.9% |
|TERMINAL (d) | 0/10 (0%) 0/0 (0%) 0/0 (0%) 0/0 (0%) 1/10 (10%) 0/0 (0%) |
|FIRST INCIDENCE | --- --- --- --- 29 (T) 4 |
|-------------------| |
|STATISTICAL TESTS | |
|-------------------| |
|LIFE TABLE | P<0.001 ** (e) (e) (e) P=0.500 P=0.005 ** |
|POLY 3 | (e) (e) (e) (e) P=0.500 P<0.001 ** |
|POLY 1.5 | (e) (e) (e) (e) P=0.500 P<0.001 ** |
|POLY 6 | (e) (e) (e) (e) P=0.500 P<0.001 ** |
|LOGISTIC REGRESSION| P=0.207 (e) (e) (e) P=0.500 (e) |
|COCH-ARM / FISHERS | P=0.015 * (e) (e) (e) P=0.500 P=0.043 * |
|ORDER RESTRICTED | (e) (e) (e) (e) (e) (e) |
|=================================================================================================================================|
Date: 10/19/04 EXPERIMENT: 60855 TEST: 02 Page 16
Statistical Analysis of Non-neoplastic Lesions in Mice(B6C3F1) - BETA-BROMO-BETA-NITROSTYRENE
Terminal Sacrifice at 5 weeks
|=================================================================================================================================|
| | |
| | Males |
|Dose | CONTROL 0.037 0.075 0.150 0.300 0.600 |
| | G/KG G/KG G/KG G/KG G/KG |
|=================================================================================================================================|
| |
|Pancreas |
| Necrosis |
| |
| |
|---------------------------------------------------------------------------------------------------------------------------------|
|LESION RATES | |
|----------- | |
|OVERALL (a) | 0/10 (0%) 0/0 (0%) 0/0 (0%) 0/0 (0%) 0/10 (0%) 3/10 (30%) |
|POLY-3 RATE (b) | 0/10.00 0/0.00 0/0.00 0/0.00 0/9.01 3/3.00 |
|POLY-3 PERCENT (g) | 0.0% 0.0% 0.0% 0.0% 0.0% 99.9% |
|TERMINAL (d) | 0/10 (0%) 0/0 (0%) 0/0 (0%) 0/0 (0%) 0/9 (0%) 0/0 (0%) |
|FIRST INCIDENCE | --- --- --- --- --- 2 |
|-------------------| |
|STATISTICAL TESTS | |
|-------------------| |
|LIFE TABLE | P<0.001 ** (e) (e) (e) (e) P=0.111 |
|POLY 3 | (e) (e) (e) (e) (e) P=0.003 ** |
|POLY 1.5 | (e) (e) (e) (e) (e) P=0.004 ** |
|POLY 6 | (e) (e) (e) (e) (e) P=0.003 ** |
|LOGISTIC REGRESSION| (e) (e) (e) (e) (e) (e) |
|COCH-ARM / FISHERS | P=0.031 * (e) (e) (e) (e) P=0.105 |
|ORDER RESTRICTED | (e) (e) (e) (e) (e) (e) |
|=================================================================================================================================|
| | |
| | Females |
|Dose | CONTROL 0.037 0.075 0.150 0.300 0.600 |
| | G/KG G/KG G/KG G/KG G/KG |
|=================================================================================================================================|
| |
|Pancreas |
| Necrosis |
| |
| |
|---------------------------------------------------------------------------------------------------------------------------------|
|LESION RATES | |
|----------- | |
|OVERALL (a) | 0/10 (0%) 0/0 (0%) 0/0 (0%) 0/1 (0%) 0/10 (0%) 1/10 (10%) |
|POLY-3 RATE (b) | 0/10.00 0/0.00 0/0.00 0/0.01 0/10.00 1/1.01 |
|POLY-3 PERCENT (g) | 0.0% 0.0% 0.0% 0.0% 0.0% 98.8% |
|TERMINAL (d) | 0/10 (0%) 0/0 (0%) 0/0 (0%) 0/0 (0%) 0/10 (0%) 0/0 (0%) |
|FIRST INCIDENCE | --- --- --- --- --- 4 |
|-------------------| |
|STATISTICAL TESTS | |
|-------------------| |
|LIFE TABLE | P=0.045 * (e) (e) (e) (e) P=0.362 |
|POLY 3 | (e) (e) (e) (e) (e) P=0.243 |
|POLY 1.5 | (e) (e) (e) (e) (e) P=0.252 |
|POLY 6 | (e) (e) (e) (e) (e) P=0.243 |
|LOGISTIC REGRESSION| P=0.869 (e) (e) (e) (e) (e) |
|COCH-ARM / FISHERS | P=0.258 (e) (e) (e) (e) P=0.500 |
|ORDER RESTRICTED | (e) (e) (e) (e) (e) (e) |
|=================================================================================================================================|
Date: 10/19/04 EXPERIMENT: 60855 TEST: 02 Page 17
Statistical Analysis of Non-neoplastic Lesions in Mice(B6C3F1) - BETA-BROMO-BETA-NITROSTYRENE
Terminal Sacrifice at 5 weeks
|=================================================================================================================================|
| | |
| | Males |
|Dose | CONTROL 0.037 0.075 0.150 0.300 0.600 |
| | G/KG G/KG G/KG G/KG G/KG |
|=================================================================================================================================|
| |
|Spleen |
| Atrophy |
| |
| |
|---------------------------------------------------------------------------------------------------------------------------------|
|LESION RATES | |
|----------- | |
|OVERALL (a) | 0/10 (0%) 0/0 (0%) 0/0 (0%) 0/0 (0%) 0/10 (0%) 6/10 (60%) |
|POLY-3 RATE (b) | 0/10.00 0/0.00 0/0.00 0/0.00 0/9.01 6/6.00 |
|POLY-3 PERCENT (g) | 0.0% 0.0% 0.0% 0.0% 0.0% 100.0% |
|TERMINAL (d) | 0/10 (0%) 0/0 (0%) 0/0 (0%) 0/0 (0%) 0/9 (0%) 0/0 (0%) |
|FIRST INCIDENCE | --- --- --- --- --- 2 |
|-------------------| |
|STATISTICAL TESTS | |
|-------------------| |
|LIFE TABLE | P<0.001 ** (e) (e) (e) (e) P=0.009 ** |
|POLY 3 | (e) (e) (e) (e) (e) P<0.001 ** |
|POLY 1.5 | (e) (e) (e) (e) (e) P<0.001 ** |
|POLY 6 | (e) (e) (e) (e) (e) P<0.001 ** |
|LOGISTIC REGRESSION| (e) (e) (e) (e) (e) (e) |
|COCH-ARM / FISHERS | P<0.001 ** (e) (e) (e) (e) P=0.005 ** |
|ORDER RESTRICTED | (e) (e) (e) (e) (e) (e) |
|=================================================================================================================================|
| | |
| | Females |
|Dose | CONTROL 0.037 0.075 0.150 0.300 0.600 |
| | G/KG G/KG G/KG G/KG G/KG |
|=================================================================================================================================|
| |
|Spleen |
| Atrophy |
| |
| |
|---------------------------------------------------------------------------------------------------------------------------------|
|LESION RATES | |
|----------- | |
|OVERALL (a) | 0/10 (0%) 0/0 (0%) 0/0 (0%) 0/2 (0%) 0/10 (0%) 1/10 (10%) |
|POLY-3 RATE (b) | 0/10.00 0/0.00 0/0.00 0/1.01 0/10.00 1/1.01 |
|POLY-3 PERCENT (g) | 0.0% 0.0% 0.0% 0.0% 0.0% 98.8% |
|TERMINAL (d) | 0/10 (0%) 0/0 (0%) 0/0 (0%) 0/1 (0%) 0/10 (0%) 0/0 (0%) |
|FIRST INCIDENCE | --- --- --- --- --- 4 |
|-------------------| |
|STATISTICAL TESTS | |
|-------------------| |
|LIFE TABLE | P=0.045 * (e) (e) (e) (e) P=0.362 |
|POLY 3 | (e) (e) (e) (e) (e) P=0.243 |
|POLY 1.5 | (e) (e) (e) (e) (e) P=0.252 |
|POLY 6 | (e) (e) (e) (e) (e) P=0.243 |
|LOGISTIC REGRESSION| P=0.870 (e) (e) (e) (e) (e) |
|COCH-ARM / FISHERS | P=0.250 (e) (e) (e) (e) P=0.500 |
|ORDER RESTRICTED | (e) (e) (e) (e) (e) (e) |
|=================================================================================================================================|
Date: 10/19/04 EXPERIMENT: 60855 TEST: 02 Page 18
Statistical Analysis of Non-neoplastic Lesions in Mice(B6C3F1) - BETA-BROMO-BETA-NITROSTYRENE
Terminal Sacrifice at 5 weeks
|=================================================================================================================================|
| | |
| | Males |
|Dose | CONTROL 0.037 0.075 0.150 0.300 0.600 |
| | G/KG G/KG G/KG G/KG G/KG |
|=================================================================================================================================|
| |
|Spleen |
| Congestion |
| |
| |
|---------------------------------------------------------------------------------------------------------------------------------|
|LESION RATES | |
|----------- | |
|OVERALL (a) | 0/10 (0%) 0/0 (0%) 0/0 (0%) 0/0 (0%) 0/10 (0%) 3/10 (30%) |
|POLY-3 RATE (b) | 0/10.00 0/0.00 0/0.00 0/0.00 0/9.01 3/3.00 |
|POLY-3 PERCENT (g) | 0.0% 0.0% 0.0% 0.0% 0.0% 99.9% |
|TERMINAL (d) | 0/10 (0%) 0/0 (0%) 0/0 (0%) 0/0 (0%) 0/9 (0%) 0/0 (0%) |
|FIRST INCIDENCE | --- --- --- --- --- 2 |
|-------------------| |
|STATISTICAL TESTS | |
|-------------------| |
|LIFE TABLE | P<0.001 ** (e) (e) (e) (e) P=0.111 |
|POLY 3 | (e) (e) (e) (e) (e) P=0.003 ** |
|POLY 1.5 | (e) (e) (e) (e) (e) P=0.004 ** |
|POLY 6 | (e) (e) (e) (e) (e) P=0.003 ** |
|LOGISTIC REGRESSION| (e) (e) (e) (e) (e) (e) |
|COCH-ARM / FISHERS | P=0.031 * (e) (e) (e) (e) P=0.105 |
|ORDER RESTRICTED | (e) (e) (e) (e) (e) (e) |
|=================================================================================================================================|
| | |
| | Females |
|Dose | CONTROL 0.037 0.075 0.150 0.300 0.600 |
| | G/KG G/KG G/KG G/KG G/KG |
|=================================================================================================================================|
| |
|Spleen |
| Congestion |
| |
| |
|---------------------------------------------------------------------------------------------------------------------------------|
|LESION RATES | |
|----------- | |
|OVERALL (a) | 0/10 (0%) 0/0 (0%) 0/0 (0%) 0/2 (0%) 0/10 (0%) 4/10 (40%) |
|POLY-3 RATE (b) | 0/10.00 0/0.00 0/0.00 0/1.01 0/10.00 4/4.01 |
|POLY-3 PERCENT (g) | 0.0% 0.0% 0.0% 0.0% 0.0% 99.7% |
|TERMINAL (d) | 0/10 (0%) 0/0 (0%) 0/0 (0%) 0/1 (0%) 0/10 (0%) 0/0 (0%) |
|FIRST INCIDENCE | --- --- --- --- --- 2 |
|-------------------| |
|STATISTICAL TESTS | |
|-------------------| |
|LIFE TABLE | P<0.001 ** (e) (e) (e) (e) P=0.051 |
|POLY 3 | (e) (e) (e) (e) (e) P<0.001 ** |
|POLY 1.5 | (e) (e) (e) (e) (e) P<0.001 ** |
|POLY 6 | (e) (e) (e) (e) (e) P<0.001 ** |
|LOGISTIC REGRESSION| (e) (e) (e) (e) (e) (e) |
|COCH-ARM / FISHERS | P=0.008 ** (e) (e) (e) (e) P=0.043 * |
|ORDER RESTRICTED | (e) (e) (e) (e) (e) (e) |
|=================================================================================================================================|
Date: 10/19/04 EXPERIMENT: 60855 TEST: 02 Page 19
Statistical Analysis of Non-neoplastic Lesions in Mice(B6C3F1) - BETA-BROMO-BETA-NITROSTYRENE
Terminal Sacrifice at 5 weeks
|=================================================================================================================================|
| | |
| | Males |
|Dose | CONTROL 0.037 0.075 0.150 0.300 0.600 |
| | G/KG G/KG G/KG G/KG G/KG |
|=================================================================================================================================|
| |
|Spleen |
| Hematopoietic Cell Proliferation |
| |
| |
|---------------------------------------------------------------------------------------------------------------------------------|
|LESION RATES | |
|----------- | |
|OVERALL (a) | 0/10 (0%) 0/0 (0%) 0/0 (0%) 0/0 (0%) 0/10 (0%) 0/10 (0%) |
|POLY-3 RATE (b) | 0/10.00 0/0.00 0/0.00 0/0.00 0/9.01 0/0.00 |
|POLY-3 PERCENT (g) | 0.0% 0.0% 0.0% 0.0% 0.0% 0.0% |
|TERMINAL (d) | 0/10 (0%) 0/0 (0%) 0/0 (0%) 0/0 (0%) 0/9 (0%) 0/0 (0%) |
|FIRST INCIDENCE | --- --- --- --- --- --- |
|-------------------| |
|STATISTICAL TESTS | |
|-------------------| |
|LIFE TABLE | (e) (e) (e) (e) (e) (e) |
|POLY 3 | (e) (e) (e) (e) (e) (e) |
|POLY 1.5 | (e) (e) (e) (e) (e) (e) |
|POLY 6 | (e) (e) (e) (e) (e) (e) |
|LOGISTIC REGRESSION| (e) (e) (e) (e) (e) (e) |
|COCH-ARM / FISHERS | (e) (e) (e) (e) (e) (e) |
|ORDER RESTRICTED | (e) (e) (e) (e) (e) (e) |
|=================================================================================================================================|
| | |
| | Females |
|Dose | CONTROL 0.037 0.075 0.150 0.300 0.600 |
| | G/KG G/KG G/KG G/KG G/KG |
|=================================================================================================================================|
| |
|Spleen |
| Hematopoietic Cell Proliferation |
| |
| |
|---------------------------------------------------------------------------------------------------------------------------------|
|LESION RATES | |
|----------- | |
|OVERALL (a) | 0/10 (0%) 0/0 (0%) 0/0 (0%) 0/2 (0%) 0/10 (0%) 2/10 (20%) |
|POLY-3 RATE (b) | 0/10.00 0/0.00 0/0.00 0/1.01 0/10.00 2/2.01 |
|POLY-3 PERCENT (g) | 0.0% 0.0% 0.0% 0.0% 0.0% 99.5% |
|TERMINAL (d) | 0/10 (0%) 0/0 (0%) 0/0 (0%) 0/1 (0%) 0/10 (0%) 0/0 (0%) |
|FIRST INCIDENCE | --- --- --- --- --- 4 |
|-------------------| |
|STATISTICAL TESTS | |
|-------------------| |
|LIFE TABLE | P<0.001 ** (e) (e) (e) (e) P=0.097 |
|POLY 3 | (e) (e) (e) (e) (e) P=0.040 * |
|POLY 1.5 | (e) (e) (e) (e) (e) P=0.044 * |
|POLY 6 | (e) (e) (e) (e) (e) P=0.040 * |
|LOGISTIC REGRESSION| P=0.686 (e) (e) (e) (e) (e) |
|COCH-ARM / FISHERS | P=0.077 (e) (e) (e) (e) P=0.237 |
|ORDER RESTRICTED | (e) (e) (e) (e) (e) (e) |
|=================================================================================================================================|
Date: 10/19/04 EXPERIMENT: 60855 TEST: 02 Page 20
Statistical Analysis of Non-neoplastic Lesions in Mice(B6C3F1) - BETA-BROMO-BETA-NITROSTYRENE
Terminal Sacrifice at 5 weeks
|=================================================================================================================================|
| | |
| | Males |
|Dose | CONTROL 0.037 0.075 0.150 0.300 0.600 |
| | G/KG G/KG G/KG G/KG G/KG |
|=================================================================================================================================|
| |
|Spleen |
| Inflammation |
| |
| |
|---------------------------------------------------------------------------------------------------------------------------------|
|LESION RATES | |
|----------- | |
|OVERALL (a) | 0/10 (0%) 0/0 (0%) 0/0 (0%) 0/0 (0%) 0/10 (0%) 0/10 (0%) |
|POLY-3 RATE (b) | 0/10.00 0/0.00 0/0.00 0/0.00 0/9.01 0/0.00 |
|POLY-3 PERCENT (g) | 0.0% 0.0% 0.0% 0.0% 0.0% 0.0% |
|TERMINAL (d) | 0/10 (0%) 0/0 (0%) 0/0 (0%) 0/0 (0%) 0/9 (0%) 0/0 (0%) |
|FIRST INCIDENCE | --- --- --- --- --- --- |
|-------------------| |
|STATISTICAL TESTS | |
|-------------------| |
|LIFE TABLE | (e) (e) (e) (e) (e) (e) |
|POLY 3 | (e) (e) (e) (e) (e) (e) |
|POLY 1.5 | (e) (e) (e) (e) (e) (e) |
|POLY 6 | (e) (e) (e) (e) (e) (e) |
|LOGISTIC REGRESSION| (e) (e) (e) (e) (e) (e) |
|COCH-ARM / FISHERS | (e) (e) (e) (e) (e) (e) |
|ORDER RESTRICTED | (e) (e) (e) (e) (e) (e) |
|=================================================================================================================================|
| | |
| | Females |
|Dose | CONTROL 0.037 0.075 0.150 0.300 0.600 |
| | G/KG G/KG G/KG G/KG G/KG |
|=================================================================================================================================|
| |
|Spleen |
| Inflammation |
| |
| |
|---------------------------------------------------------------------------------------------------------------------------------|
|LESION RATES | |
|----------- | |
|OVERALL (a) | 0/10 (0%) 0/0 (0%) 0/0 (0%) 0/2 (0%) 0/10 (0%) 2/10 (20%) |
|POLY-3 RATE (b) | 0/10.00 0/0.00 0/0.00 0/1.01 0/10.00 2/2.01 |
|POLY-3 PERCENT (g) | 0.0% 0.0% 0.0% 0.0% 0.0% 99.5% |
|TERMINAL (d) | 0/10 (0%) 0/0 (0%) 0/0 (0%) 0/1 (0%) 0/10 (0%) 0/0 (0%) |
|FIRST INCIDENCE | --- --- --- --- --- 4 |
|-------------------| |
|STATISTICAL TESTS | |
|-------------------| |
|LIFE TABLE | P<0.001 ** (e) (e) (e) (e) P=0.097 |
|POLY 3 | (e) (e) (e) (e) (e) P=0.040 * |
|POLY 1.5 | (e) (e) (e) (e) (e) P=0.044 * |
|POLY 6 | (e) (e) (e) (e) (e) P=0.040 * |
|LOGISTIC REGRESSION| P=0.686 (e) (e) (e) (e) (e) |
|COCH-ARM / FISHERS | P=0.077 (e) (e) (e) (e) P=0.237 |
|ORDER RESTRICTED | (e) (e) (e) (e) (e) (e) |
|=================================================================================================================================|
Date: 10/19/04 EXPERIMENT: 60855 TEST: 02 Page 21
Statistical Analysis of Non-neoplastic Lesions in Mice(B6C3F1) - BETA-BROMO-BETA-NITROSTYRENE
Terminal Sacrifice at 5 weeks
|=================================================================================================================================|
| | |
| | Males |
|Dose | CONTROL 0.037 0.075 0.150 0.300 0.600 |
| | G/KG G/KG G/KG G/KG G/KG |
|=================================================================================================================================|
| |
|Stomach, Forestomach |
| Inflammation |
| |
| |
|---------------------------------------------------------------------------------------------------------------------------------|
|LESION RATES | |
|----------- | |
|OVERALL (a) | 0/10 (0%) 0/10 (0%) 0/10 (0%) 0/10 (0%) 0/10 (0%) 1/10 (10%) |
|POLY-3 RATE (b) | 0/10.00 0/10.00 0/10.00 0/10.00 0/9.01 1/1.00 |
|POLY-3 PERCENT (g) | 0.0% 0.0% 0.0% 0.0% 0.0% 99.7% |
|TERMINAL (d) | 0/10 (0%) 0/10 (0%) 0/10 (0%) 0/10 (0%) 0/9 (0%) 0/0 (0%) |
|FIRST INCIDENCE | --- --- --- --- --- 2 |
|-------------------| |
|STATISTICAL TESTS | |
|-------------------| |
|LIFE TABLE | P=0.107 (e) (e) (e) (e) P=0.500 |
|POLY 3 | P=0.569 (e) (e) (e) (e) P=0.243 |
|POLY 1.5 | P=0.538 (e) (e) (e) (e) P=0.248 |
|POLY 6 | P=0.569 (e) (e) (e) (e) P=0.243 |
|LOGISTIC REGRESSION| (e) (e) (e) (e) (e) (e) |
|COCH-ARM / FISHERS | P=0.105 (e) (e) (e) (e) P=0.500 |
|ORDER RESTRICTED | P=0.009 ** (e) (e) (e) (e) (e) |
|=================================================================================================================================|
| | |
| | Females |
|Dose | CONTROL 0.037 0.075 0.150 0.300 0.600 |
| | G/KG G/KG G/KG G/KG G/KG |
|=================================================================================================================================|
| |
|Stomach, Forestomach |
| Inflammation |
| |
| |
|---------------------------------------------------------------------------------------------------------------------------------|
|LESION RATES | |
|----------- | |
|OVERALL (a) | 0/10 (0%) 0/10 (0%) 0/10 (0%) 0/10 (0%) 0/10 (0%) 8/10 (80%) |
|POLY-3 RATE (b) | 0/10.00 0/10.00 0/10.00 0/9.01 0/10.00 8/8.00 |
|POLY-3 PERCENT (g) | 0.0% 0.0% 0.0% 0.0% 0.0% 100.0% |
|TERMINAL (d) | 0/10 (0%) 0/10 (0%) 0/10 (0%) 0/9 (0%) 0/10 (0%) 0/0 (0%) |
|FIRST INCIDENCE | --- --- --- --- --- 2 |
|-------------------| |
|STATISTICAL TESTS | |
|-------------------| |
|LIFE TABLE | P<0.001 ** (e) (e) (e) (e) P<0.001 ** |
|POLY 3 | P<0.001 ** (e) (e) (e) (e) P<0.001 ** |
|POLY 1.5 | P<0.001 ** (e) (e) (e) (e) P<0.001 ** |
|POLY 6 | P<0.001 ** (e) (e) (e) (e) P<0.001 ** |
|LOGISTIC REGRESSION| P=0.279 (e) (e) (e) (e) (e) |
|COCH-ARM / FISHERS | P<0.001 ** (e) (e) (e) (e) P<0.001 ** |
|ORDER RESTRICTED | P<0.001 ** (e) (e) (e) (e) (e) |
|=================================================================================================================================|
Date: 10/19/04 EXPERIMENT: 60855 TEST: 02 Page 22
Statistical Analysis of Non-neoplastic Lesions in Mice(B6C3F1) - BETA-BROMO-BETA-NITROSTYRENE
Terminal Sacrifice at 5 weeks
|=================================================================================================================================|
| | |
| | Males |
|Dose | CONTROL 0.037 0.075 0.150 0.300 0.600 |
| | G/KG G/KG G/KG G/KG G/KG |
|=================================================================================================================================|
| |
|Stomach, Forestomach |
| Necrosis |
| |
| |
|---------------------------------------------------------------------------------------------------------------------------------|
|LESION RATES | |
|----------- | |
|OVERALL (a) | 0/10 (0%) 0/10 (0%) 0/10 (0%) 0/10 (0%) 0/10 (0%) 0/10 (0%) |
|POLY-3 RATE (b) | 0/10.00 0/10.00 0/10.00 0/10.00 0/9.01 0/0.00 |
|POLY-3 PERCENT (g) | 0.0% 0.0% 0.0% 0.0% 0.0% 0.0% |
|TERMINAL (d) | 0/10 (0%) 0/10 (0%) 0/10 (0%) 0/10 (0%) 0/9 (0%) 0/0 (0%) |
|FIRST INCIDENCE | --- --- --- --- --- --- |
|-------------------| |
|STATISTICAL TESTS | |
|-------------------| |
|LIFE TABLE | (e) (e) (e) (e) (e) (e) |
|POLY 3 | (e) (e) (e) (e) (e) (e) |
|POLY 1.5 | (e) (e) (e) (e) (e) (e) |
|POLY 6 | (e) (e) (e) (e) (e) (e) |
|LOGISTIC REGRESSION| (e) (e) (e) (e) (e) (e) |
|COCH-ARM / FISHERS | (e) (e) (e) (e) (e) (e) |
|ORDER RESTRICTED | (e) (e) (e) (e) (e) (e) |
|=================================================================================================================================|
| | |
| | Females |
|Dose | CONTROL 0.037 0.075 0.150 0.300 0.600 |
| | G/KG G/KG G/KG G/KG G/KG |
|=================================================================================================================================|
| |
|Stomach, Forestomach |
| Necrosis |
| |
| |
|---------------------------------------------------------------------------------------------------------------------------------|
|LESION RATES | |
|----------- | |
|OVERALL (a) | 0/10 (0%) 0/10 (0%) 0/10 (0%) 0/10 (0%) 0/10 (0%) 4/10 (40%) |
|POLY-3 RATE (b) | 0/10.00 0/10.00 0/10.00 0/9.01 0/10.00 4/4.00 |
|POLY-3 PERCENT (g) | 0.0% 0.0% 0.0% 0.0% 0.0% 99.9% |
|TERMINAL (d) | 0/10 (0%) 0/10 (0%) 0/10 (0%) 0/9 (0%) 0/10 (0%) 0/0 (0%) |
|FIRST INCIDENCE | --- --- --- --- --- 4 |
|-------------------| |
|STATISTICAL TESTS | |
|-------------------| |
|LIFE TABLE | P<0.001 ** (e) (e) (e) (e) P=0.005 ** |
|POLY 3 | P<0.001 ** (e) (e) (e) (e) P<0.001 ** |
|POLY 1.5 | P<0.001 ** (e) (e) (e) (e) P<0.001 ** |
|POLY 6 | P<0.001 ** (e) (e) (e) (e) P<0.001 ** |
|LOGISTIC REGRESSION| P=0.437 (e) (e) (e) (e) (e) |
|COCH-ARM / FISHERS | P<0.001 ** (e) (e) (e) (e) P=0.043 * |
|ORDER RESTRICTED | P<0.001 ** (e) (e) (e) (e) (e) |
|=================================================================================================================================|
Date: 10/19/04 EXPERIMENT: 60855 TEST: 02 Page 23
Statistical Analysis of Non-neoplastic Lesions in Mice(B6C3F1) - BETA-BROMO-BETA-NITROSTYRENE
Terminal Sacrifice at 5 weeks
|=================================================================================================================================|
| | |
| | Males |
|Dose | CONTROL 0.037 0.075 0.150 0.300 0.600 |
| | G/KG G/KG G/KG G/KG G/KG |
|=================================================================================================================================|
| |
|Stomach, Forestomach |
| Ulcer |
| |
| |
|---------------------------------------------------------------------------------------------------------------------------------|
|LESION RATES | |
|----------- | |
|OVERALL (a) | 0/10 (0%) 0/10 (0%) 0/10 (0%) 0/10 (0%) 2/10 (20%) 0/10 (0%) |
|POLY-3 RATE (b) | 0/10.00 0/10.00 0/10.00 0/10.00 2/10.00 0/0.00 |
|POLY-3 PERCENT (g) | 0.0% 0.0% 0.0% 0.0% 20.0% 0.0% |
|TERMINAL (d) | 0/10 (0%) 0/10 (0%) 0/10 (0%) 0/10 (0%) 1/9 (11%) 0/0 (0%) |
|FIRST INCIDENCE | --- --- --- --- 6 --- |
|-------------------| |
|STATISTICAL TESTS | |
|-------------------| |
|LIFE TABLE | P=0.061 (e) (e) (e) P=0.228 (e) |
|POLY 3 | P=0.010 * (e) (e) (e) P=0.227 (e) |
|POLY 1.5 | P=0.010 * (e) (e) (e) P=0.227 (e) |
|POLY 6 | P=0.010 * (e) (e) (e) P=0.227 (e) |
|LOGISTIC REGRESSION| P=0.855N (e) (e) (e) (e) (e) |
|COCH-ARM / FISHERS | P=0.413 (e) (e) (e) P=0.237 (e) |
|ORDER RESTRICTED | P=0.830 (e) (e) (e) (e) (e) |
|=================================================================================================================================|
| | |
| | Females |
|Dose | CONTROL 0.037 0.075 0.150 0.300 0.600 |
| | G/KG G/KG G/KG G/KG G/KG |
|=================================================================================================================================|
| |
|Stomach, Forestomach |
| Ulcer |
| |
| |
|---------------------------------------------------------------------------------------------------------------------------------|
|LESION RATES | |
|----------- | |
|OVERALL (a) | 0/10 (0%) 0/10 (0%) 0/10 (0%) 0/10 (0%) 0/10 (0%) 0/10 (0%) |
|POLY-3 RATE (b) | 0/10.00 0/10.00 0/10.00 0/9.01 0/10.00 0/0.02 |
|POLY-3 PERCENT (g) | 0.0% 0.0% 0.0% 0.0% 0.0% 0.0% |
|TERMINAL (d) | 0/10 (0%) 0/10 (0%) 0/10 (0%) 0/9 (0%) 0/10 (0%) 0/0 (0%) |
|FIRST INCIDENCE | --- --- --- --- --- --- |
|-------------------| |
|STATISTICAL TESTS | |
|-------------------| |
|LIFE TABLE | (e) (e) (e) (e) (e) (e) |
|POLY 3 | (e) (e) (e) (e) (e) (e) |
|POLY 1.5 | (e) (e) (e) (e) (e) (e) |
|POLY 6 | (e) (e) (e) (e) (e) (e) |
|LOGISTIC REGRESSION| (e) (e) (e) (e) (e) (e) |
|COCH-ARM / FISHERS | (e) (e) (e) (e) (e) (e) |
|ORDER RESTRICTED | (e) (e) (e) (e) (e) (e) |
|=================================================================================================================================|
Date: 10/19/04 EXPERIMENT: 60855 TEST: 02 Page 24
Statistical Analysis of Non-neoplastic Lesions in Mice(B6C3F1) - BETA-BROMO-BETA-NITROSTYRENE
Terminal Sacrifice at 5 weeks
|=================================================================================================================================|
| | |
| | Males |
|Dose | CONTROL 0.037 0.075 0.150 0.300 0.600 |
| | G/KG G/KG G/KG G/KG G/KG |
|=================================================================================================================================|
| |
|Stomach, Forestomach: Epithelium |
| Hyperkeratosis |
| |
| |
|---------------------------------------------------------------------------------------------------------------------------------|
|LESION RATES | |
|----------- | |
|OVERALL (a) | 0/10 (0%) 0/10 (0%) 0/10 (0%) 0/10 (0%) 9/10 (90%) 0/10 (0%) |
|POLY-3 RATE (b) | 0/10.00 0/10.00 0/10.00 0/10.00 9/9.01 0/0.00 |
|POLY-3 PERCENT (g) | 0.0% 0.0% 0.0% 0.0% 99.9% 0.0% |
|TERMINAL (d) | 0/10 (0%) 0/10 (0%) 0/10 (0%) 0/10 (0%) 9/9 (100%) 0/0 (0%) |
|FIRST INCIDENCE | --- --- --- --- 29 (T) --- |
|-------------------| |
|STATISTICAL TESTS | |
|-------------------| |
|LIFE TABLE | P<0.001 ** (e) (e) (e) P<0.001 ** (e) |
|POLY 3 | P<0.001 ** (e) (e) (e) P<0.001 ** (e) |
|POLY 1.5 | P<0.001 ** (e) (e) (e) P<0.001 ** (e) |
|POLY 6 | P<0.001 ** (e) (e) (e) P<0.001 ** (e) |
|LOGISTIC REGRESSION| P<0.001 ** (e) (e) (e) P<0.001 ** (e) |
|COCH-ARM / FISHERS | P=0.078 (e) (e) (e) P<0.001 ** (e) |
|ORDER RESTRICTED | P=0.827 (e) (e) (e) (e) (e) |
|=================================================================================================================================|
| | |
| | Females |
|Dose | CONTROL 0.037 0.075 0.150 0.300 0.600 |
| | G/KG G/KG G/KG G/KG G/KG |
|=================================================================================================================================|
| |
|Stomach, Forestomach: Epithelium |
| Hyperkeratosis |
| |
| |
|---------------------------------------------------------------------------------------------------------------------------------|
|LESION RATES | |
|----------- | |
|OVERALL (a) | 0/10 (0%) 0/10 (0%) 0/10 (0%) 0/10 (0%) 2/10 (20%) 0/10 (0%) |
|POLY-3 RATE (b) | 0/10.00 0/10.00 0/10.00 0/9.01 2/10.00 0/0.02 |
|POLY-3 PERCENT (g) | 0.0% 0.0% 0.0% 0.0% 20.0% 0.0% |
|TERMINAL (d) | 0/10 (0%) 0/10 (0%) 0/10 (0%) 0/9 (0%) 2/10 (20%) 0/0 (0%) |
|FIRST INCIDENCE | --- --- --- --- 29 (T) --- |
|-------------------| |
|STATISTICAL TESTS | |
|-------------------| |
|LIFE TABLE | P=0.065 (e) (e) (e) P=0.234 (e) |
|POLY 3 | P=0.010 * (e) (e) (e) P=0.227 (e) |
|POLY 1.5 | P=0.010 * (e) (e) (e) P=0.227 (e) |
|POLY 6 | P=0.010 * (e) (e) (e) P=0.227 (e) |
|LOGISTIC REGRESSION| (e) (e) (e) (e) P=0.234 (e) |
|COCH-ARM / FISHERS | P=0.413 (e) (e) (e) P=0.237 (e) |
|ORDER RESTRICTED | P=0.829 (e) (e) (e) (e) (e) |
|=================================================================================================================================|
Date: 10/19/04 EXPERIMENT: 60855 TEST: 02 Page 25
Statistical Analysis of Non-neoplastic Lesions in Mice(B6C3F1) - BETA-BROMO-BETA-NITROSTYRENE
Terminal Sacrifice at 5 weeks
|=================================================================================================================================|
| | |
| | Males |
|Dose | CONTROL 0.037 0.075 0.150 0.300 0.600 |
| | G/KG G/KG G/KG G/KG G/KG |
|=================================================================================================================================|
| |
|Stomach, Forestomach: Epithelium |
| Hyperplasia |
| |
| |
|---------------------------------------------------------------------------------------------------------------------------------|
|LESION RATES | |
|----------- | |
|OVERALL (a) | 0/10 (0%) 0/10 (0%) 0/10 (0%) 0/10 (0%) 9/10 (90%) 0/10 (0%) |
|POLY-3 RATE (b) | 0/10.00 0/10.00 0/10.00 0/10.00 9/9.01 0/0.00 |
|POLY-3 PERCENT (g) | 0.0% 0.0% 0.0% 0.0% 99.9% 0.0% |
|TERMINAL (d) | 0/10 (0%) 0/10 (0%) 0/10 (0%) 0/10 (0%) 9/9 (100%) 0/0 (0%) |
|FIRST INCIDENCE | --- --- --- --- 29 (T) --- |
|-------------------| |
|STATISTICAL TESTS | |
|-------------------| |
|LIFE TABLE | P<0.001 ** (e) (e) (e) P<0.001 ** (e) |
|POLY 3 | P<0.001 ** (e) (e) (e) P<0.001 ** (e) |
|POLY 1.5 | P<0.001 ** (e) (e) (e) P<0.001 ** (e) |
|POLY 6 | P<0.001 ** (e) (e) (e) P<0.001 ** (e) |
|LOGISTIC REGRESSION| P<0.001 ** (e) (e) (e) P<0.001 ** (e) |
|COCH-ARM / FISHERS | P=0.078 (e) (e) (e) P<0.001 ** (e) |
|ORDER RESTRICTED | P=0.827 (e) (e) (e) (e) (e) |
|=================================================================================================================================|
| | |
| | Females |
|Dose | CONTROL 0.037 0.075 0.150 0.300 0.600 |
| | G/KG G/KG G/KG G/KG G/KG |
|=================================================================================================================================|
| |
|Stomach, Forestomach: Epithelium |
| Hyperplasia |
| |
| |
|---------------------------------------------------------------------------------------------------------------------------------|
|LESION RATES | |
|----------- | |
|OVERALL (a) | 0/10 (0%) 0/10 (0%) 0/10 (0%) 0/10 (0%) 10/10 (100%) 0/10 (0%) |
|POLY-3 RATE (b) | 0/10.00 0/10.00 0/10.00 0/9.01 10/10.00 0/0.02 |
|POLY-3 PERCENT (g) | 0.0% 0.0% 0.0% 0.0% 100.0% 0.0% |
|TERMINAL (d) | 0/10 (0%) 0/10 (0%) 0/10 (0%) 0/9 (0%) 10/10 (100%) 0/0 (0%) |
|FIRST INCIDENCE | --- --- --- --- 29 (T) --- |
|-------------------| |
|STATISTICAL TESTS | |
|-------------------| |
|LIFE TABLE | P<0.001 ** (e) (e) (e) P<0.001 ** (e) |
|POLY 3 | P<0.001 ** (e) (e) (e) P<0.001 ** (e) |
|POLY 1.5 | P<0.001 ** (e) (e) (e) P<0.001 ** (e) |
|POLY 6 | P<0.001 ** (e) (e) (e) P<0.001 ** (e) |
|LOGISTIC REGRESSION| (e) (e) (e) (e) P<0.001 ** (e) |
|COCH-ARM / FISHERS | P=0.062 (e) (e) (e) P<0.001 ** (e) |
|ORDER RESTRICTED | P=0.745 (e) (e) (e) (e) (e) |
|=================================================================================================================================|
Date: 10/19/04 EXPERIMENT: 60855 TEST: 02 Page 26
Statistical Analysis of Non-neoplastic Lesions in Mice(B6C3F1) - BETA-BROMO-BETA-NITROSTYRENE
Terminal Sacrifice at 5 weeks
|=================================================================================================================================|
| | |
| | Males |
|Dose | CONTROL 0.037 0.075 0.150 0.300 0.600 |
| | G/KG G/KG G/KG G/KG G/KG |
|=================================================================================================================================|
| |
|Stomach, Glandular |
| Inflammation |
| |
| |
|---------------------------------------------------------------------------------------------------------------------------------|
|LESION RATES | |
|----------- | |
|OVERALL (a) | 0/10 (0%) 0/0 (0%) 0/0 (0%) 0/10 (0%) 0/10 (0%) 0/10 (0%) |
|POLY-3 RATE (b) | 0/10.00 0/0.00 0/0.00 0/10.00 0/9.01 0/0.00 |
|POLY-3 PERCENT (g) | 0.0% 0.0% 0.0% 0.0% 0.0% 0.0% |
|TERMINAL (d) | 0/10 (0%) 0/0 (0%) 0/0 (0%) 0/10 (0%) 0/9 (0%) 0/0 (0%) |
|FIRST INCIDENCE | --- --- --- --- --- --- |
|-------------------| |
|STATISTICAL TESTS | |
|-------------------| |
|LIFE TABLE | (e) (e) (e) (e) (e) (e) |
|POLY 3 | (e) (e) (e) (e) (e) (e) |
|POLY 1.5 | (e) (e) (e) (e) (e) (e) |
|POLY 6 | (e) (e) (e) (e) (e) (e) |
|LOGISTIC REGRESSION| (e) (e) (e) (e) (e) (e) |
|COCH-ARM / FISHERS | (e) (e) (e) (e) (e) (e) |
|ORDER RESTRICTED | (e) (e) (e) (e) (e) (e) |
|=================================================================================================================================|
| | |
| | Females |
|Dose | CONTROL 0.037 0.075 0.150 0.300 0.600 |
| | G/KG G/KG G/KG G/KG G/KG |
|=================================================================================================================================|
| |
|Stomach, Glandular |
| Inflammation |
| |
| |
|---------------------------------------------------------------------------------------------------------------------------------|
|LESION RATES | |
|----------- | |
|OVERALL (a) | 0/10 (0%) 0/0 (0%) 0/0 (0%) 0/10 (0%) 0/10 (0%) 2/10 (20%) |
|POLY-3 RATE (b) | 0/10.00 0/0.00 0/0.00 0/9.01 0/10.00 2/2.01 |
|POLY-3 PERCENT (g) | 0.0% 0.0% 0.0% 0.0% 0.0% 99.5% |
|TERMINAL (d) | 0/10 (0%) 0/0 (0%) 0/0 (0%) 0/9 (0%) 0/10 (0%) 0/0 (0%) |
|FIRST INCIDENCE | --- --- --- --- --- 4 |
|-------------------| |
|STATISTICAL TESTS | |
|-------------------| |
|LIFE TABLE | P<0.001 ** (e) (e) (e) (e) P=0.097 |
|POLY 3 | (e) (e) (e) (e) (e) P=0.040 * |
|POLY 1.5 | (e) (e) (e) (e) (e) P=0.044 * |
|POLY 6 | (e) (e) (e) (e) (e) P=0.040 * |
|LOGISTIC REGRESSION| P=0.693 (e) (e) (e) (e) (e) |
|COCH-ARM / FISHERS | P=0.043 * (e) (e) (e) (e) P=0.237 |
|ORDER RESTRICTED | (e) (e) (e) (e) (e) (e) |
|=================================================================================================================================|
Date: 10/19/04 EXPERIMENT: 60855 TEST: 02 Page 27
Statistical Analysis of Non-neoplastic Lesions in Mice(B6C3F1) - BETA-BROMO-BETA-NITROSTYRENE
Terminal Sacrifice at 5 weeks
|=================================================================================================================================|
| | |
| | Males |
|Dose | CONTROL 0.037 0.075 0.150 0.300 0.600 |
| | G/KG G/KG G/KG G/KG G/KG |
|=================================================================================================================================|
| |
|Testes |
| Degeneration |
| |
| |
|---------------------------------------------------------------------------------------------------------------------------------|
|LESION RATES | |
|----------- | |
|OVERALL (a) | 0/10 (0%) 0/0 (0%) 0/0 (0%) 0/0 (0%) 0/10 (0%) 6/10 (60%) |
|POLY-3 RATE (b) | 0/10.00 0/0.00 0/0.00 0/0.00 0/9.01 6/6.00 |
|POLY-3 PERCENT (g) | 0.0% 0.0% 0.0% 0.0% 0.0% 100.0% |
|TERMINAL (d) | 0/10 (0%) 0/0 (0%) 0/0 (0%) 0/0 (0%) 0/9 (0%) 0/0 (0%) |
|FIRST INCIDENCE | --- --- --- --- --- 2 |
|-------------------| |
|STATISTICAL TESTS | |
|-------------------| |
|LIFE TABLE | P<0.001 ** (e) (e) (e) (e) P=0.009 ** |
|POLY 3 | (e) (e) (e) (e) (e) P<0.001 ** |
|POLY 1.5 | (e) (e) (e) (e) (e) P<0.001 ** |
|POLY 6 | (e) (e) (e) (e) (e) P<0.001 ** |
|LOGISTIC REGRESSION| (e) (e) (e) (e) (e) (e) |
|COCH-ARM / FISHERS | P<0.001 ** (e) (e) (e) (e) P=0.005 ** |
|ORDER RESTRICTED | (e) (e) (e) (e) (e) (e) |
|=================================================================================================================================|
| | |
| | Females |
|Dose | CONTROL 0.037 0.075 0.150 0.300 0.600 |
| | G/KG G/KG G/KG G/KG G/KG |
|=================================================================================================================================|
| |
|Testes |
| Degeneration |
| |
| |
|---------------------------------------------------------------------------------------------------------------------------------|
|LESION RATES | |
|----------- | |
|OVERALL (a) | |
|POLY-3 RATE (b) | |
|POLY-3 PERCENT (g) | |
|TERMINAL (d) | |
|FIRST INCIDENCE | |
|-------------------| |
|STATISTICAL TESTS | |
|-------------------| |
|LIFE TABLE | |
|POLY 3 | |
|POLY 1.5 | |
|POLY 6 | |
|LOGISTIC REGRESSION| |
|COCH-ARM / FISHERS | |
|ORDER RESTRICTED | |
|=================================================================================================================================|
Date: 10/19/04 EXPERIMENT: 60855 TEST: 02 Page 28
Statistical Analysis of Non-neoplastic Lesions in Mice(B6C3F1) - BETA-BROMO-BETA-NITROSTYRENE
Terminal Sacrifice at 5 weeks
|=================================================================================================================================|
| | |
| | Males |
|Dose | CONTROL 0.037 0.075 0.150 0.300 0.600 |
| | G/KG G/KG G/KG G/KG G/KG |
|=================================================================================================================================|
| |
|Thymus |
| Atrophy |
| |
| |
|---------------------------------------------------------------------------------------------------------------------------------|
|LESION RATES | |
|----------- | |
|OVERALL (a) | 0/10 (0%) 0/0 (0%) 0/0 (0%) 0/0 (0%) 0/10 (0%) 3/10 (30%) |
|POLY-3 RATE (b) | 0/10.00 0/0.00 0/0.00 0/0.00 0/9.01 3/3.00 |
|POLY-3 PERCENT (g) | 0.0% 0.0% 0.0% 0.0% 0.0% 99.9% |
|TERMINAL (d) | 0/10 (0%) 0/0 (0%) 0/0 (0%) 0/0 (0%) 0/9 (0%) 0/0 (0%) |
|FIRST INCIDENCE | --- --- --- --- --- 2 |
|-------------------| |
|STATISTICAL TESTS | |
|-------------------| |
|LIFE TABLE | P<0.001 ** (e) (e) (e) (e) P=0.111 |
|POLY 3 | (e) (e) (e) (e) (e) P=0.003 ** |
|POLY 1.5 | (e) (e) (e) (e) (e) P=0.004 ** |
|POLY 6 | (e) (e) (e) (e) (e) P=0.003 ** |
|LOGISTIC REGRESSION| (e) (e) (e) (e) (e) (e) |
|COCH-ARM / FISHERS | P=0.031 * (e) (e) (e) (e) P=0.105 |
|ORDER RESTRICTED | (e) (e) (e) (e) (e) (e) |
|=================================================================================================================================|
| | |
| | Females |
|Dose | CONTROL 0.037 0.075 0.150 0.300 0.600 |
| | G/KG G/KG G/KG G/KG G/KG |
|=================================================================================================================================|
| |
|Thymus |
| Atrophy |
| |
| |
|---------------------------------------------------------------------------------------------------------------------------------|
|LESION RATES | |
|----------- | |
|OVERALL (a) | 0/9 (0%) 0/0 (0%) 0/0 (0%) 0/1 (0%) 0/10 (0%) 2/8 (25%) |
|POLY-3 RATE (b) | 0/9.00 0/0.00 0/0.00 0/0.01 0/10.00 2/2.00 |
|POLY-3 PERCENT (g) | 0.0% 0.0% 0.0% 0.0% 0.0% 99.8% |
|TERMINAL (d) | 0/9 (0%) 0/0 (0%) 0/0 (0%) 0/0 (0%) 0/10 (0%) 0/0 (0%) |
|FIRST INCIDENCE | --- --- --- --- --- 4 |
|-------------------| |
|STATISTICAL TESTS | |
|-------------------| |
|LIFE TABLE | P<0.001 ** (e) (e) (e) (e) P=0.034 * |
|POLY 3 | (e) (e) (e) (e) (e) P=0.032 * |
|POLY 1.5 | (e) (e) (e) (e) (e) P=0.035 * |
|POLY 6 | (e) (e) (e) (e) (e) P=0.032 * |
|LOGISTIC REGRESSION| P=0.632 (e) (e) (e) (e) (e) |
|COCH-ARM / FISHERS | P=0.066 (e) (e) (e) (e) P=0.206 |
|ORDER RESTRICTED | (e) (e) (e) (e) (e) (e) |
|=================================================================================================================================|
Date: 10/19/04 EXPERIMENT: 60855 TEST: 02 Page 29
Statistical Analysis of Non-neoplastic Lesions in Mice(B6C3F1) - BETA-BROMO-BETA-NITROSTYRENE
Terminal Sacrifice at 5 weeks
|=================================================================================================================================|
| | |
| | Males |
|Dose | CONTROL 0.037 0.075 0.150 0.300 0.600 |
| | G/KG G/KG G/KG G/KG G/KG |
|=================================================================================================================================|
| |
|Thymus |
| Necrosis |
| |
| |
|---------------------------------------------------------------------------------------------------------------------------------|
|LESION RATES | |
|----------- | |
|OVERALL (a) | 0/10 (0%) 0/0 (0%) 0/0 (0%) 0/0 (0%) 0/10 (0%) 8/10 (80%) |
|POLY-3 RATE (b) | 0/10.00 0/0.00 0/0.00 0/0.00 0/9.01 8/8.00 |
|POLY-3 PERCENT (g) | 0.0% 0.0% 0.0% 0.0% 0.0% 100.0% |
|TERMINAL (d) | 0/10 (0%) 0/0 (0%) 0/0 (0%) 0/0 (0%) 0/9 (0%) 0/0 (0%) |
|FIRST INCIDENCE | --- --- --- --- --- 2 |
|-------------------| |
|STATISTICAL TESTS | |
|-------------------| |
|LIFE TABLE | P<0.001 ** (e) (e) (e) (e) P<0.001 ** |
|POLY 3 | (e) (e) (e) (e) (e) P<0.001 ** |
|POLY 1.5 | (e) (e) (e) (e) (e) P<0.001 ** |
|POLY 6 | (e) (e) (e) (e) (e) P<0.001 ** |
|LOGISTIC REGRESSION| (e) (e) (e) (e) (e) (e) |
|COCH-ARM / FISHERS | P<0.001 ** (e) (e) (e) (e) P<0.001 ** |
|ORDER RESTRICTED | (e) (e) (e) (e) (e) (e) |
|=================================================================================================================================|
| | |
| | Females |
|Dose | CONTROL 0.037 0.075 0.150 0.300 0.600 |
| | G/KG G/KG G/KG G/KG G/KG |
|=================================================================================================================================|
| |
|Thymus |
| Necrosis |
| |
| |
|---------------------------------------------------------------------------------------------------------------------------------|
|LESION RATES | |
|----------- | |
|OVERALL (a) | 0/9 (0%) 0/0 (0%) 0/0 (0%) 0/1 (0%) 0/10 (0%) 6/8 (75%) |
|POLY-3 RATE (b) | 0/9.00 0/0.00 0/0.00 0/0.01 0/10.00 6/6.01 |
|POLY-3 PERCENT (g) | 0.0% 0.0% 0.0% 0.0% 0.0% 99.9% |
|TERMINAL (d) | 0/9 (0%) 0/0 (0%) 0/0 (0%) 0/0 (0%) 0/10 (0%) 0/0 (0%) |
|FIRST INCIDENCE | --- --- --- --- --- 2 |
|-------------------| |
|STATISTICAL TESTS | |
|-------------------| |
|LIFE TABLE | P<0.001 ** (e) (e) (e) (e) P=0.005 ** |
|POLY 3 | (e) (e) (e) (e) (e) P<0.001 ** |
|POLY 1.5 | (e) (e) (e) (e) (e) P<0.001 ** |
|POLY 6 | (e) (e) (e) (e) (e) P<0.001 ** |
|LOGISTIC REGRESSION| (e) (e) (e) (e) (e) (e) |
|COCH-ARM / FISHERS | P<0.001 ** (e) (e) (e) (e) P=0.002 ** |
|ORDER RESTRICTED | (e) (e) (e) (e) (e) (e) |
|=================================================================================================================================|
(a) Number of tumor-bearing animals / number of animals examined at site.
(b) Number of tumor-bearing animals / Poly-3 number
(d) Observed incidence at terminal kill.
(f) Beneath the control incidence are the P-values associated with the trend
test. Beneath the dosed group incidence are the P-values corresponding to
pairwise comparisons between the controls and that dosed group. The life
table analysis regards tumors in animals dying prior to terminal kill as
being (directly or indirectly) the cause of death.
Logistic regression is an alternative
method for analyzing the incidence of non-fatal tumors. The Cochran-Armitage
and Fishers exact tests compare directly the overall incidence rates
For all tests a negative trend is indicated by N
(e) Value of Statistic cannot be computed.
(g) Poly-3 adjusted lifetime tumor incidence.
(I) Interim sacrifice
(T) Terminal sacrifice
# Tumor rates based on number of animals necropsied.
* To the right of any statistical result, indicates significance at (P<=0.05).
** To the right of any statistical result, indicates significance at (P<=0.01).