TDMS Study 92013-05 Pathology Tables
NTP EXP/TEST: 92013-05 4-METHYLIMIDAZOLE PAGE: 1
TEST TYPE: CHRONIC INDIVIDUAL BODY WEIGHT TABLE DATE: 11/29/04
ROUTE: DOSED FEED TIME: 09:48:49
EIS REPORT 12
FACILITY: Southern Research Institute
NTP C#: 92013B
CONTRACT NUMBER: N01-ES-85420
CAS NUMBER: 822-36-6
ANIMAL SUPPLIER: TACONIC FARMS
CAGE RANGE: ALL
DATE RANGE: ALL
REASONS FOR REMOVAL: ALL
REMOVAL DATE RANGE: ALL
TREATMENT GROUPS: INCLUDE ALL
NTP EXP/TEST: 92013-05 4-METHYLIMIDAZOLE PAGE: 2
TEST TYPE: CHRONIC INDIVIDUAL BODY WEIGHT TABLE DATE: 11/29/04
ROUTE: DOSED FEED EISRPT12 TIME: 09:48:49
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SPECIES-STRAIN: RATS-F 344 SEX: FEMALE TRT: 0 PPM TRT#: 2 FIRST-DOSE: 01/20/00
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CAGE ANIMAL DAY ON DOSE
NO ID 1 13 20 27 34 41 48 55 62 69 76 83 90
----------------------------------------------------------------------------------------------------------------------------------
69 201 99.5 126.3 132.9 143.9 150.6 155.6 162.8 165.5 168.3 169.4 171.7 178.3 176.4
69 202 111.8 139.2 147.6 155.9 160.2 169.2 176.0 187.5 184.3 189.1 194.9 194.1 198.4
69 203 98.7 136.4 147.1 154.6 163.2 172.7 179.1 191.9 187.2 195.7 199.3 198.6 203.0
69 204 95.3 121.5 133.4 139.8 146.4 152.6 157.4 166.5 167.3 171.0 176.8 174.9 179.5
69 205 107.4 138.7 146.9 158.4 167.1 172.9 183.3 188.7 189.9 194.5 200.0 200.7 203.4
70 206 102.1 138.3 146.7 157.6 166.4 171.9 179.9 189.7 194.9 196.5 196.0 196.5 196.9
70 207 108.7 141.4 151.9 163.6 170.8 179.8 185.7 198.1 202.5 203.7 207.8 207.6 213.2
70 208 89.1 120.3 130.1 135.2 144.7 149.9 155.2 160.9 163.6 167.0 170.1 169.2 174.1
70 209 106.0 131.9 141.2 151.8 160.2 169.9 176.1 186.1 185.5 187.6 192.6 191.9 195.1
70 210 86.4 115.9 126.9 137.2 145.4 150.7 156.3 161.6 166.2 168.4 171.1 175.2 176.9
71 211 93.5 120.3 132.5 141.0 152.8 162.5 172.0 180.3 185.2 184.0 188.7 189.1 192.8
71 212 103.4 130.0 138.2 149.5 155.6 161.8 174.9 183.9 181.4 183.6 184.3 185.9 189.1
71 213 108.6 121.1 142.0 147.5 157.5 162.9 175.2 181.4 184.3 182.6 187.0 187.6 191.1
71 214 103.7 133.8 141.8 153.4 163.1 171.8 181.0 192.4 193.8 197.9 196.5 196.4 203.5
71 215 94.4 116.1 122.1 130.3 138.3 147.5 152.1 159.4 160.1 160.3 163.9 162.1 163.9
72 216 112.1 136.1 144.6 151.3 159.3 164.8 174.9 182.3 184.3 186.8 190.1 186.0 191.3
72 217 102.1 129.2 136.8 150.4 159.2 164.7 169.9 176.8 169.8 178.2 178.7 179.0 183.1
72 218 102.3 116.5 124.8 131.1 139.6 149.7 152.9 161.0 160.5 165.9 169.6 170.3 171.2
72 219 101.6 127.2 133.4 140.8 149.2 154.8 166.0 168.7 169.7 172.9 176.8 179.9 180.0
72 220 85.8 114.4 126.9 136.0 143.5 151.0 159.5 147.3 164.7 171.5 172.9 173.9 174.8
73 221 101.3 138.3 146.6 158.3 162.4 176.2 177.2 184.2 190.8 193.2 202.4 201.1 206.0
73 222 112.7 137.4 144.6 159.5 159.7 164.5 172.6 180.8 177.4 187.8 192.8 190.3 192.6
73 223 110.2 137.2 143.0 153.7 159.9 164.8 172.1 180.6 182.8 189.4 190.1 189.4 194.9
73 224 106.2 142.3 154.0 165.9 175.8 184.0 187.0 195.4 202.7 204.2 211.1 211.3 213.2
73 225 87.2 120.2 128.3 137.4 147.2 157.5 163.6 171.2 174.1 178.1 182.7 185.8 189.7
74 226 99.9 129.2 137.4 151.1 154.4 162.8 169.2 174.1 178.8 184.6 191.5 193.0 196.7
74 227 109.0 133.2 143.3 154.8 158.7 164.5 167.1 174.4 173.1 176.6 180.0 180.4 184.5
74 228 85.5 110.9 123.0 131.6 136.8 146.5 149.6 158.6 157.5 162.5 166.4 165.4 172.3
74 229 104.4 128.3 141.7 151.7 157.2 163.7 169.5 173.6 177.7 180.6 185.9 186.2 191.1
74 230 86.9 120.0 131.8 145.0 150.9 154.5 160.6 166.0 167.9 172.3 177.2 180.2 184.0
75 231 110.8 139.1 151.2 162.5 170.3 178.9 181.2 192.7 192.6 192.6 200.9 201.9 204.1
75 232 102.9 138.6 153.5 166.7 172.1 181.7 186.2 198.0 196.6 201.0 207.7 209.3 212.8
75 233 102.5 126.3 133.1 145.2 147.6 156.0 158.4 164.3 164.1 167.8 169.2 169.2 170.2
75 234 94.9 127.9 140.3 147.6 155.5 162.5 163.2 171.8 169.6 175.8 180.0 180.6 184.9
75 235 95.8 131.4 144.6 156.4 160.7 171.2 178.5 184.8 183.6 191.7 196.4 197.2 199.7
76 236 93.8 122.5 132.3 141.0 151.0 157.1 162.3 172.5 170.7 173.9 176.1 178.0 180.5
76 237 109.2 133.5 144.3 158.2 165.2 174.5 176.4 186.9 183.2 192.6 196.0 197.7 198.2
76 238 95.6 125.6 135.1 146.7 149.4 159.7 163.6 171.1 168.7 176.7 180.4 181.5 186.5
76 239 99.5 127.8 139.5 147.0 154.1 159.0 164.8 170.9 171.0 176.4 183.8 181.8 188.2
76 240 111.7 141.5 152.3 168.1 174.3 181.8 188.9 195.8 196.4 202.4 204.3 207.0 206.6
77 241 97.1 131.6 142.5 155.6 159.9 171.8 177.2 181.9 185.6 189.5 195.8 196.9 202.1
77 242 105.3 134.8 142.2 150.2 155.1 161.5 164.5 172.8 174.6 181.0 183.6 182.8 190.3
77 243 104.9 132.2 139.6 151.0 157.7 163.3 167.0 179.0 182.6 189.6 193.8 196.0 194.5
77 244 99.4 117.8 126.5 134.7 139.2 147.6 146.4 150.6 153.6 158.4 164.1 163.7 166.9
77 245 89.1 74.1 @
78 246 99.0 125.8 134.2 145.5 155.7 163.0 167.1 173.1 175.3 180.5 187.3 192.7 194.8
78 247 91.4 116.8 130.7 141.1 148.5 159.6 157.6 166.3 168.2 173.6 182.3 182.4 185.6
NTP EXP/TEST: 92013-05 4-METHYLIMIDAZOLE PAGE: 3
TEST TYPE: CHRONIC INDIVIDUAL BODY WEIGHT TABLE DATE: 11/29/04
ROUTE: DOSED FEED EISRPT12 TIME: 09:48:49
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SPECIES-STRAIN: RATS-F 344 SEX: FEMALE TRT: 0 PPM TRT#: 2 FIRST-DOSE: 01/20/00
----------------------------------------------------------------------------------------------------------------------------------
CAGE ANIMAL DAY ON DOSE
NO ID 1 13 20 27 34 41 48 55 62 69 76 83 90
----------------------------------------------------------------------------------------------------------------------------------
78 248 106.8 129.5 139.6 150.1 156.6 162.2 168.3 173.2 170.8 180.6 184.4 185.8 189.1
78 249 79.2 112.1 123.0 133.2 137.6 145.2 149.9 155.7 156.0 160.9 166.9 166.2 170.3
78 250 101.6 128.4 134.9 147.1 152.0 161.7 165.4 172.2 173.9 176.7 182.3 185.3 186.2
----- ----- ----- ----- ----- ----- ----- ----- ----- ----- ----- ----- -----
MEAN WT(G) 100.1 127.4 138.4 148.7 155.5 163.1 168.7 176.0 177.2 181.6 185.8 186.5 189.7
SD 8.2 11.4 8.5 9.8 9.6 9.9 10.7 12.5 12.2 12.0 12.3 12.3 12.4
NO. OBSER. 50 50 49 49 49 49 49 49 49 49 49 49 49
BLANK MISSING DATA @ ANIMAL REMOVED FROM STUDY
() TRT# OF THE CONTROL GROUP USED IN CALCULATION * MULTIPLE OBSERVATIONS, LAST WEIGHT DISPLAYED
NTP EXP/TEST: 92013-05 4-METHYLIMIDAZOLE PAGE: 4
TEST TYPE: CHRONIC INDIVIDUAL BODY WEIGHT TABLE DATE: 11/29/04
ROUTE: DOSED FEED EISRPT12 TIME: 09:48:49
----------------------------------------------------------------------------------------------------------------------------------
SPECIES-STRAIN: RATS-F 344 SEX: FEMALE TRT: 0 PPM TRT#: 2 FIRST-DOSE: 01/20/00
----------------------------------------------------------------------------------------------------------------------------------
CAGE ANIMAL DAY ON DOSE
NO ID 118 146 174 202 230 258 286 314 342 370 398 426 454
----------------------------------------------------------------------------------------------------------------------------------
69 201 189.0 200.9 202.8 211.4 216.1 216.3 218.0 230.4 233.3 240.3 243.2 252.6 268.1
69 202 202.3 214.5 219.5 229.3 229.5 235.0 233.7 244.9 253.7 261.1 273.4 290.9 292.6
69 203 204.7 212.3 220.6 227.7 228.6 232.8 234.2 246.1 249.9 258.9 273.9 279.1 285.0
69 204 180.9 189.4 195.9 199.5 200.0 206.1 201.7 210.0 218.3 214.3 226.0 244.7 244.6
69 205 210.3 217.7 226.5 233.9 238.7 240.5 241.9 255.4 256.0 258.4 265.7 279.0 278.2
70 206 201.6 207.9 219.0 225.3 235.5 234.2 228.1 237.7 234.9 239.9 240.4 253.0 268.4
70 207 221.0 229.5 241.2 243.5 256.5 258.1 263.8 271.2 282.1 285.6 296.0 311.9 324.3
70 208 180.5 191.6 203.5 201.9 213.9 210.1 212.4 215.3 220.2 223.4 230.9 241.0 256.6
70 209 199.3 209.4 221.9 226.0 233.5 230.6 235.9 246.4 250.0 265.3 270.9 284.5 290.3
70 210 186.3 192.9 202.0 209.8 217.9 217.8 217.6 226.7 221.8 235.8 238.6 250.5 263.6
71 211 195.0 208.6 210.8 228.5 230.9 240.3 240.7 257.6 267.2 276.3 284.7 298.1 291.6
71 212 189.6 197.3 206.2 207.2 220.4 223.1 221.4 233.0 235.4 242.1 246.1 282.7 269.1
71 213 192.8 199.5 209.1 214.1 225.8 226.6 224.0 232.4 233.6 241.4 240.3 275.8 265.2
71 214 208.9 213.6 226.7 236.6 244.1 242.1 248.2 255.7 261.7 270.0 278.3 303.0 295.1
71 215 171.0 179.9 188.0 192.9 200.0 200.4 202.4 208.6 212.3 218.0 220.6 244.6 234.9
72 216 198.1 206.1 213.9 221.6 229.5 232.2 234.8 239.6 247.1 257.2 273.1 277.8 288.1
72 217 191.3 197.6 207.6 207.5 212.2 219.5 220.9 227.2 230.0 238.3 238.4 263.3 263.9
72 218 177.9 182.4 192.0 201.7 201.5 208.8 212.1 213.7 217.3 222.6 229.1 245.6 254.5
72 219 186.3 194.1 200.7 207.7 209.5 216.1 221.4 219.4 228.0 237.2 237.7 247.8 262.7
72 220 181.2 192.1 202.4 208.7 209.6 216.0 219.6 225.4 232.2 248.4 264.4 272.4 280.5
73 221 211.1 221.6 231.0 238.8 245.9 254.1 246.2 271.2 273.0 288.2 303.5 314.4 324.3
73 222 197.7 207.7 213.2 220.3 224.0 237.6 229.3 251.2 265.4 271.5 275.5 283.5 289.7
73 223 197.9 206.6 214.3 218.4 222.9 233.1 228.6 243.3 246.2 248.2 256.8 262.3 277.0
73 224 220.3 233.5 234.1 240.4 247.3 250.7 255.1 275.4 280.8 283.3 292.7 310.7 328.7
73 225 193.6 206.2 208.7 217.4 224.7 228.2 226.5 242.9 244.9 252.2 262.6 268.4 289.2
74 226 200.1 208.3 213.0 228.2 224.2 235.6 230.1 239.9 243.3 252.5 260.0 267.6 270.8
74 227 186.7 197.3 205.7 209.5 216.6 225.4 233.2 235.7 237.9 247.0 248.8 260.2 259.4
74 228 177.8 189.6 200.7 205.7 208.2 211.9 214.4 223.7 229.1 235.8 243.5 254.3 259.7
74 229 188.7 199.8 210.2 216.4 217.8 222.9 225.2 233.0 235.7 237.5 242.6 253.9 260.2
74 230 192.1 197.5 204.2 207.1 210.4 218.2 219.6 224.5 231.2 231.7 235.7 242.0 246.4
75 231 205.2 213.6 223.0 224.9 233.4 238.8 234.1 246.9 246.5 257.5 258.1 275.1 274.5
75 232 216.0 230.5 237.5 241.5 249.6 256.7 250.2 272.2 277.0 289.6 308.8 319.2 324.5
75 233 174.4 185.1 191.1 194.3 200.8 210.0 206.3 217.2 213.5 222.7 226.4 229.5 238.4
75 234 186.7 196.7 206.8 208.8 214.8 223.5 219.9 230.3 229.4 236.4 238.4 245.9 253.3
75 235 199.8 211.4 221.2 224.4 233.5 239.5 234.2 254.6 258.4 274.2 243.1 296.5 308.9
76 236 185.2 195.0 204.5 205.4 214.7 219.2 209.8 225.7 229.1 237.8 244.9 243.9 253.5
76 237 202.9 211.0 218.2 227.5 230.6 240.5 232.4 @
76 238 191.8 199.2 210.7 209.5 214.7 219.4 216.3 235.3 238.2 247.1 254.8 270.8 273.1
76 239 196.3 203.7 211.0 215.3 218.7 223.6 215.5 234.5 233.8 240.7 254.7 269.2 278.8
76 240 219.3 232.9 234.4 248.4 252.8 262.2 257.6 286.0 304.9 314.7 227.4 334.5 330.1
77 241 208.2 216.0 210.1 223.2 235.3 244.7 247.3 253.7 262.4 276.9 280.0 286.3 292.8
77 242 192.9 209.1 218.5 218.3 222.2 236.8 231.5 240.9 247.6 255.3 269.7 284.1 289.0
77 243 196.7 208.4 217.1 215.8 225.4 227.3 236.6 237.3 239.6 252.2 255.4 267.9 275.8
77 244 173.6 187.2 191.3 192.1 200.2 207.2 209.3 212.1 213.7 221.7 228.2 233.9 238.0
77 245
78 246 196.6 204.1 216.6 228.0 232.4 237.5 237.2 247.9 249.0 259.4 264.5 276.0 277.4
78 247 187.7 200.9 207.9 212.4 221.4 228.4 228.7 239.3 235.6 249.7 253.8 264.5 275.6
NTP EXP/TEST: 92013-05 4-METHYLIMIDAZOLE PAGE: 5
TEST TYPE: CHRONIC INDIVIDUAL BODY WEIGHT TABLE DATE: 11/29/04
ROUTE: DOSED FEED EISRPT12 TIME: 09:48:49
----------------------------------------------------------------------------------------------------------------------------------
SPECIES-STRAIN: RATS-F 344 SEX: FEMALE TRT: 0 PPM TRT#: 2 FIRST-DOSE: 01/20/00
----------------------------------------------------------------------------------------------------------------------------------
CAGE ANIMAL DAY ON DOSE
NO ID 118 146 174 202 230 258 286 314 342 370 398 426 454
----------------------------------------------------------------------------------------------------------------------------------
78 248 193.0 201.5 210.8 212.4 219.5 227.6 222.9 230.0 230.3 239.7 238.5 237.2 231.9
78 249 173.0 183.0 193.7 196.7 204.5 213.0 213.0 219.2 229.8 233.7 241.0 248.2 247.6
78 250 194.0 195.6 207.4 212.9 212.0 215.4 214.5 223.3 225.6 237.1 246.0 265.4 272.1
----- ----- ----- ----- ----- ----- ----- ----- ----- ----- ----- ----- -----
MEAN WT(G) 194.4 203.9 211.8 217.3 223.1 228.5 227.7 238.4 242.4 250.6 254.7 270.1 275.4
SD 12.4 12.8 12.3 13.7 14.3 14.5 14.3 18.0 19.9 21.1 21.4 24.3 24.7
NO. OBSER. 49 49 49 49 49 49 49 48 48 48 48 48 48
BLANK MISSING DATA @ ANIMAL REMOVED FROM STUDY
() TRT# OF THE CONTROL GROUP USED IN CALCULATION * MULTIPLE OBSERVATIONS, LAST WEIGHT DISPLAYED
NTP EXP/TEST: 92013-05 4-METHYLIMIDAZOLE PAGE: 6
TEST TYPE: CHRONIC INDIVIDUAL BODY WEIGHT TABLE DATE: 11/29/04
ROUTE: DOSED FEED EISRPT12 TIME: 09:48:49
----------------------------------------------------------------------------------------------------------------------------------
SPECIES-STRAIN: RATS-F 344 SEX: FEMALE TRT: 0 PPM TRT#: 2 FIRST-DOSE: 01/20/00
----------------------------------------------------------------------------------------------------------------------------------
CAGE ANIMAL DAY ON DOSE
NO ID 482 510 538 566 594 622 650 678 706
----------------------------------------------------------------------------------------------------------------------------------
69 201 267.1 275.1 283.0 299.5 299.9 297.7 305.1 316.5 320.6
69 202 292.4 295.4 305.1 306.5 315.4 313.8 316.0 327.2 329.0
69 203 292.6 290.2 292.7 305.1 303.9 301.6 303.6 318.8 324.7
69 204 247.3 248.3 261.6 267.2 270.5 269.0 273.2 277.2 284.8
69 205 287.8 287.6 296.3 300.2 308.0 306.0 311.0 315.3 314.2
70 206 261.2 270.4 274.6 280.3 282.4 284.3 289.3 289.6 291.6
70 207 324.8 327.1 337.0 333.5 338.5 349.1 353.8 344.8 368.7
70 208 249.8 255.8 262.9 268.2 273.8 281.4 291.3 299.0 309.0
70 209 292.2 292.7 304.4 305.2 308.3 317.7 319.5 319.8 312.2
70 210 265.1 269.6 278.7 281.0 288.2 288.1 294.2 291.3 301.1
71 211 296.7 297.6 304.2 314.5 312.4 320.8 325.2 329.0 329.7
71 212 272.0 270.9 285.2 287.8 285.6 291.5 295.7 290.5 300.4
71 213 263.5 258.7 271.6 282.4 273.8 288.5 294.3 296.1 311.5
71 214 304.8 310.2 312.0 318.8 317.3 317.1 324.1 320.3 329.6
71 215 235.5 233.6 238.3 244.6 246.8 254.8 265.9 265.7 273.1
72 216 290.9 292.3 300.8 300.3 295.5 298.4 312.9 318.1 319.6
72 217 258.5 269.0 276.7 284.7 285.0 294.9 301.9 304.6 312.7
72 218 250.0 249.1 260.4 261.1 260.2 271.7 274.2 276.7 284.2
72 219 260.1 263.1 269.7 284.7 285.9 291.3 297.6 302.9 308.1 @
72 220 281.6 290.0 299.1 309.6 302.2 295.9 @
73 221 327.4 327.1 332.6 328.5 335.9 331.8 316.4 324.0 @
73 222 294.7 301.7 310.2 311.6 314.0 322.7 329.0 328.1 329.0
73 223 277.1 285.6 293.6 303.0 299.7 309.0 315.2 310.5 327.0
73 224 330.1 333.9 348.1 344.8 352.8 363.0 360.7 309.7 334.9 @
73 225 289.4 290.2 289.8 295.1 278.6 287.9 288.2 247.7 280.1
74 226 281.6 286.6 289.7 294.9 299.4 299.1 302.6 258.7 315.2
74 227 273.1 271.2 277.5 284.8 288.8 301.7 304.8 276.0 319.9
74 228 267.5 278.3 274.4 281.6 288.3 286.4 293.9 257.5 298.2
74 229 275.1 280.9 286.2 289.9 281.5 295.2 308.8 268.8 311.7
74 230 253.8 259.4 262.6 264.4 264.5 267.5 276.8 241.0 278.6
75 231 281.0 291.7 297.7 301.7 304.1 311.5 317.4 312.4 309.8 @
75 232 327.2 329.8 335.3 335.5 333.7 335.6 346.8 353.2 355.6
75 233 241.1 246.7 250.1 265.0 265.0 272.7 274.5 280.3 292.7
75 234 259.6 261.5 268.0 281.4 280.7 288.3 291.2 290.6 294.9
75 235 312.9 318.7 318.1 323.2 325.6 332.5 335.1 326.7 349.4
76 236 263.7 263.6 272.5 280.1 284.2 289.9 275.1 @
76 237
76 238 278.2 273.6 279.9 286.4 286.3 286.6 295.8 289.4 305.8
76 239 288.0 289.2 291.3 303.7 303.2 303.3 308.5 293.9 273.9
76 240 333.5 344.2 350.8 354.2 342.4 346.1 350.1 338.6 347.6
77 241 298.0 305.2 311.0 316.6 313.3 310.0 315.7 326.4 326.5
77 242 248.0 295.3 300.8 310.2 317.3 303.4 274.4 275.4 245.7
77 243 280.6 278.2 277.5 275.5 271.8 278.4 278.5 286.1 298.7
77 244 244.9 255.4 256.9 265.6 270.6 279.9 290.7 225.1 @
77 245
78 246 290.1 298.7 306.5 311.9 311.5 314.8 324.0 333.5 339.5
78 247 281.9 290.1 297.1 305.3 309.9 312.1 319.9 324.5 323.0
NTP EXP/TEST: 92013-05 4-METHYLIMIDAZOLE PAGE: 7
TEST TYPE: CHRONIC INDIVIDUAL BODY WEIGHT TABLE DATE: 11/29/04
ROUTE: DOSED FEED EISRPT12 TIME: 09:48:49
----------------------------------------------------------------------------------------------------------------------------------
SPECIES-STRAIN: RATS-F 344 SEX: FEMALE TRT: 0 PPM TRT#: 2 FIRST-DOSE: 01/20/00
----------------------------------------------------------------------------------------------------------------------------------
CAGE ANIMAL DAY ON DOSE
NO ID 482 510 538 566 594 622 650 678 706
----------------------------------------------------------------------------------------------------------------------------------
78 248 228.3 @
78 249 253.8 258.7 268.2 280.3 285.4 286.4 291.0 296.3 299.3
78 250 278.9 288.4 291.0 300.7 300.2 306.3 303.6 300.8 304.0
----- ----- ----- ----- ----- ----- ----- ----- -----
MEAN WT(G) 278.2 284.1 290.5 296.4 297.1 301.2 305.2 299.5 311.3
SD 25.5 24.7 24.9 22.9 23.1 22.3 22.5 28.5 24.0
NO. OBSER. 48 47 47 47 47 47 46 45 43
BLANK MISSING DATA @ ANIMAL REMOVED FROM STUDY
() TRT# OF THE CONTROL GROUP USED IN CALCULATION * MULTIPLE OBSERVATIONS, LAST WEIGHT DISPLAYED
NTP EXP/TEST: 92013-05 4-METHYLIMIDAZOLE PAGE: 8
TEST TYPE: CHRONIC INDIVIDUAL BODY WEIGHT TABLE DATE: 11/29/04
ROUTE: DOSED FEED EISRPT12 TIME: 09:48:49
----------------------------------------------------------------------------------------------------------------------------------
SPECIES-STRAIN: RATS-F 344 SEX: FEMALE TRT: 1250 PPM TRT#: 4 FIRST-DOSE: 01/20/00
----------------------------------------------------------------------------------------------------------------------------------
CAGE ANIMAL DAY ON DOSE
NO ID 1 13 20 27 34 41 48 55 62 69 76 83 90
----------------------------------------------------------------------------------------------------------------------------------
79 251 108.9 132.5 142.4 153.9 156.4 164.4 169.3 173.2 174.6 176.7 177.9 179.6 183.3
79 252 90.7 118.0 130.7 141.3 144.2 154.3 156.2 161.7 164.3 164.1 166.4 168.5 173.1
79 253 109.0 136.8 149.3 161.1 168.4 176.6 183.0 189.7 190.9 194.7 198.6 200.2 205.2
79 254 93.9 127.0 139.7 153.8 160.0 168.5 175.3 185.3 184.7 187.9 189.7 191.2 196.1
79 255 101.9 126.5 136.5 146.9 154.4 163.0 167.2 170.6 173.1 175.9 176.7 177.9 182.5
80 256 102.9 130.6 141.5 152.3 161.1 171.0 172.8 176.0 178.2 178.3 182.3 183.9 185.2
80 257 103.4 132.5 139.2 152.3 160.0 169.0 173.4 181.2 181.0 178.7 185.2 184.2 185.6
80 258 98.3 124.6 135.6 146.3 152.2 160.6 164.0 170.5 170.2 170.6 172.9 177.9 178.8
80 259 83.3 109.3 120.2 132.9 138.6 146.7 148.2 156.7 158.4 163.7 168.5 170.5 173.8
80 260 103.2 108.8 136.6 146.4 153.2 163.0 166.7 176.5 174.9 172.2 177.0 175.9 177.3
81 261 103.3 132.0 141.9 154.8 156.1 161.9 166.6 175.4 174.0 176.6 180.8 182.6 185.6
81 262 103.6 130.0 138.3 152.1 152.5 160.8 162.8 170.1 170.4 168.2 170.9 173.5 179.3
81 263 102.1 128.2 138.8 150.5 159.4 171.6 176.0 183.6 184.9 187.5 190.4 192.5 194.3
81 264 98.1 116.1 137.2 146.1 152.8 162.7 167.7 173.9 175.8 176.6 178.8 179.0 178.7
81 265 86.2 113.9 128.1 140.8 145.2 152.2 157.6 165.6 168.3 168.5 170.4 174.9 174.1
82 266 106.6 136.0 150.3 162.1 173.0 180.0 184.0 190.3 192.7 194.0 195.6 198.3 196.8
82 267 99.0 120.8 133.7 144.4 151.6 158.0 163.8 169.5 175.1 177.6 181.2 179.6 179.4
82 268 107.8 133.4 142.9 152.6 161.7 169.8 171.8 174.9 177.7 176.1 175.2 179.1 186.7
82 269 94.7 124.5 135.8 145.1 154.3 156.2 162.1 167.4 173.7 179.0 177.2 183.9 187.1
82 270 94.9 121.0 135.6 146.1 154.7 163.3 169.0 173.6 179.3 182.7 185.9 191.0 190.3
83 271 94.9 129.1 140.7 152.7 157.7 165.4 171.7 180.1 182.7 184.8 187.4 192.6 194.2
83 272 95.0 127.9 142.2 154.0 161.4 170.1 175.0 185.7 186.7 187.7 187.4 192.6 194.3
83 273 105.1 130.9 145.0 155.5 159.6 163.4 168.1 174.5 175.3 176.4 178.4 177.9 182.0
83 274 98.6 124.1 140.4 147.0 149.6 154.9 156.2 165.7 167.8 168.5 170.2 177.2 178.2
83 275 88.9 122.0 140.7 153.7 158.7 168.0 172.2 184.1 187.2 187.9 188.5 189.0 194.4
84 276 99.6 122.6 131.6 144.0 149.0 153.4 157.2 162.8 162.8 165.2 168.1 170.7 173.1
84 277 106.5 125.4 135.8 145.5 151.1 158.5 159.5 162.9 162.0 164.4 168.7 171.9 172.5
84 278 85.0 120.1 136.5 151.2 156.5 163.9 168.8 176.3 174.1 178.0 181.2 184.2 187.7
84 279 87.7 112.7 121.9 135.8 141.3 148.1 153.7 158.8 157.8 160.5 164.6 163.5 167.6
84 280 84.6 113.6 127.8 142.4 149.5 158.4 163.3 169.7 168.6 173.6 177.8 178.7 180.8
85 281 83.1 113.3 126.2 139.2 147.8 152.5 156.7 160.4 161.4 165.2 170.0 168.7 171.4
85 282 91.7 118.2 129.1 144.4 150.1 155.6 154.6 160.3 160.9 163.5 168.7 166.0 168.9
85 283 108.8 130.7 142.5 152.5 160.7 168.1 174.3 179.8 186.5 191.2 192.6 195.1 196.5
85 284 98.9 124.2 136.8 150.7 156.9 164.1 167.8 175.7 177.8 178.0 184.7 182.5 184.6
85 285 95.3 120.6 132.0 146.3 150.4 158.2 165.5 169.9 171.0 174.0 175.6 175.4 177.3
86 286 100.8 126.2 136.9 140.8 162.6 168.7 171.6 178.7 176.9 178.5 179.7 178.9 180.0
86 287 102.2 126.5 140.2 152.0 169.4 172.2 176.2 178.1 177.5 179.5 181.3 179.3 182.6
86 288 104.6 128.1 135.8 141.7 147.4 151.1 155.0 162.9 159.5 164.5 168.0 168.9 170.1
86 289 95.9 125.2 139.4 153.9 164.2 169.6 175.7 180.2 180.6 183.5 185.8 183.6 184.3
86 290 87.5 113.8 121.7 134.7 144.0 149.4 149.3 154.1 154.5 158.5 163.4 161.6 161.3
87 291 101.1 118.4 133.2 142.7 149.5 156.4 160.8 165.7 167.4 171.7 174.2 178.1 181.3
87 292 91.5 118.3 134.4 144.8 147.7 152.3 156.4 161.5 164.6 165.2 172.3 174.0 174.2
87 293 106.5 134.0 147.2 153.1 162.0 169.5 174.0 182.2 183.2 185.7 188.2 186.8 188.8
87 294 99.4 124.7 138.5 149.3 155.0 160.3 163.6 168.1 168.3 169.4 171.4 173.7 177.1
87 295 94.9 124.2 148.6 150.0 159.6 162.8 164.6 167.5 171.0 173.9 177.4 177.8 181.0
88 296 101.2 128.3 141.5 152.0 159.2 165.6 171.2 177.9 177.9 181.2 183.9 182.4 185.3
88 297 109.2 136.4 147.4 159.1 163.8 168.8 174.9 182.4 179.4 184.4 186.2 185.1 187.8
NTP EXP/TEST: 92013-05 4-METHYLIMIDAZOLE PAGE: 9
TEST TYPE: CHRONIC INDIVIDUAL BODY WEIGHT TABLE DATE: 11/29/04
ROUTE: DOSED FEED EISRPT12 TIME: 09:48:49
----------------------------------------------------------------------------------------------------------------------------------
SPECIES-STRAIN: RATS-F 344 SEX: FEMALE TRT: 1250 PPM TRT#: 4 FIRST-DOSE: 01/20/00
----------------------------------------------------------------------------------------------------------------------------------
CAGE ANIMAL DAY ON DOSE
NO ID 1 13 20 27 34 41 48 55 62 69 76 83 90
----------------------------------------------------------------------------------------------------------------------------------
88 298 85.9 109.6 121.5 132.0 135.2 142.0 146.4 152.6 151.0 155.5 154.8 159.5 162.7
88 299 105.3 132.1 144.0 155.1 161.5 169.8 173.8 181.4 179.2 180.8 184.0 181.8 188.2
88 300 95.9 125.4 135.8 146.4 151.4 159.8 166.0 174.1 174.9 177.1 181.2 180.0 185.2
----- ----- ----- ----- ----- ----- ----- ----- ----- ----- ----- ----- -----
MEAN WT(G) 97.9 124.2 137.0 148.1 154.9 161.9 166.0 172.4 173.4 175.6 178.3 179.6 182.1
SD 7.5 7.4 7.2 6.8 7.7 8.0 8.7 9.2 9.5 9.3 9.0 9.0 9.2
NO. OBSER. 50 50 50 50 50 50 50 50 50 50 50 50 50
AVE. BODY WT
REL. TO CNTL 0.98 0.97 0.99 1.00 1.00 0.99 0.98 0.98 0.98 0.97 0.96 0.96 0.96
(TRT#: 2 )
BLANK MISSING DATA @ ANIMAL REMOVED FROM STUDY
() TRT# OF THE CONTROL GROUP USED IN CALCULATION * MULTIPLE OBSERVATIONS, LAST WEIGHT DISPLAYED
NTP EXP/TEST: 92013-05 4-METHYLIMIDAZOLE PAGE: 10
TEST TYPE: CHRONIC INDIVIDUAL BODY WEIGHT TABLE DATE: 11/29/04
ROUTE: DOSED FEED EISRPT12 TIME: 09:48:49
----------------------------------------------------------------------------------------------------------------------------------
SPECIES-STRAIN: RATS-F 344 SEX: FEMALE TRT: 1250 PPM TRT#: 4 FIRST-DOSE: 01/20/00
----------------------------------------------------------------------------------------------------------------------------------
CAGE ANIMAL DAY ON DOSE
NO ID 118 146 174 202 230 258 286 314 342 370 398 426 454
----------------------------------------------------------------------------------------------------------------------------------
79 251 190.2 196.1 202.7 203.0 210.2 214.7 217.9 221.3 227.1 232.3 236.7 239.3 239.8
79 252 178.6 183.2 192.7 195.2 202.7 207.1 207.9 211.5 215.5 215.5 220.5 228.3 230.6
79 253 207.6 217.0 226.1 231.5 238.6 243.2 242.9 245.0 249.2 251.9 254.5 261.3 267.1
79 254 208.1 211.8 226.6 231.2 236.1 248.3 253.1 262.7 263.9 268.4 269.4 279.5 283.1
79 255 191.4 191.7 197.8 204.3 210.5 212.6 215.7 215.3 220.4 221.8 228.7 232.1 231.5
80 256 191.2 194.7 204.0 204.9 209.9 210.6 213.5 215.5 215.6 222.7 220.6 @
80 257 191.8 193.7 203.6 208.8 211.1 216.1 216.6 222.3 220.5 220.3 224.3 231.2 229.0 @
80 258 183.5 184.7 193.2 196.5 207.3 211.0 206.2 216.3 214.7 219.2 221.9 233.8 243.2
80 259 179.4 183.8 194.1 199.3 208.2 213.7 208.5 216.2 219.6 221.3 229.8 230.8 236.9
80 260 186.2 187.3 196.8 201.5 210.1 215.5 212.4 216.7 218.1 224.6 220.8 222.3 224.7
81 261 197.9 202.7 205.8 214.8 218.9 221.7 223.4 226.1 228.0 233.4 233.7 236.3 244.1
81 262 185.7 190.5 193.7 208.0 213.3 215.1 217.1 220.0 224.4 229.7 231.4 241.4 240.1
81 263 196.2 206.0 211.8 218.7 233.4 230.2 232.5 235.9 231.8 236.9 237.4 247.6 249.8
81 264 182.6 188.7 194.6 204.7 208.8 209.5 211.6 213.8 217.9 222.2 221.7 228.5 230.7
81 265 185.2 191.3 198.0 208.2 215.8 216.1 221.7 223.7 226.5 236.5 240.4 252.1 264.8
82 266 204.8 209.0 217.7 227.2 233.8 242.4 245.2 251.9 259.6 258.6 264.4 274.5 278.9
82 267 185.8 190.6 199.7 200.8 205.6 214.0 216.1 219.2 225.9 223.9 225.8 229.1 240.5
82 268 186.3 194.6 200.1 206.5 211.8 221.8 222.4 225.5 228.2 227.8 231.8 237.3 244.0
82 269 191.3 192.4 199.1 205.5 205.8 217.8 214.6 213.9 220.5 221.2 227.9 228.6 240.6
82 270 190.1 195.5 203.9 206.7 213.5 219.3 222.9 230.1 234.7 235.8 232.7 233.6 239.3
83 271 200.9 206.0 217.5 222.9 228.1 233.9 236.9 241.1 248.4 254.3 258.6 254.9 265.6
83 272 203.1 210.2 220.4 227.8 234.5 243.5 244.5 254.9 260.3 262.3 263.8 271.1 276.4
83 273 187.3 195.4 204.6 212.4 217.9 221.9 222.5 230.0 227.2 235.7 241.3 241.3 246.6
83 274 187.5 196.6 202.8 209.7 211.4 212.2 216.6 223.7 225.2 222.7 234.1 232.2 234.9
83 275 199.8 208.0 213.4 220.2 229.1 234.4 236.1 243.7 244.1 248.9 254.5 250.5 255.1
84 276 181.2 184.2 191.3 196.3 209.8 206.7 211.9 212.0 215.4 222.5 220.4 208.6 @
84 277 181.5 189.0 197.5 201.0 208.5 208.5 215.6 215.9 221.1 227.6 228.4 232.3 240.3
84 278 190.9 197.5 205.8 210.6 220.9 217.1 222.0 226.3 228.4 232.3 234.2 240.0 241.2
84 279 172.3 179.8 186.8 193.8 205.3 207.7 206.9 208.9 212.1 220.7 217.7 223.5 229.4
84 280 190.1 195.8 199.9 210.1 215.6 216.6 219.9 224.7 222.0 229.6 230.6 234.7 240.2
85 281 177.9 184.0 193.0 195.5 197.5 200.1 200.6 198.8 204.6 213.5 212.9 216.5 215.0
85 282 174.0 181.7 186.2 187.9 190.1 191.5 192.3 191.3 195.5 198.8 204.6 207.2 204.6
85 283 198.7 203.1 211.7 221.9 226.2 234.9 235.7 236.7 237.0 243.4 244.1 249.3 253.4
85 284 191.5 199.6 206.0 208.7 215.4 219.3 222.5 226.4 230.2 234.3 233.6 237.6 244.5
85 285 183.9 189.5 195.4 202.3 206.4 208.5 211.6 211.7 217.8 225.9 230.4 232.6 236.2
86 286 191.0 199.7 206.3 216.5 221.7 225.3 228.1 233.9 241.4 253.3 248.4 255.9 260.5
86 287 191.2 197.7 200.4 207.5 214.0 214.9 215.1 216.7 224.5 232.1 229.7 232.1 227.8
86 288 177.3 177.2 190.7 192.6 195.3 194.6 202.3 195.2 196.1 202.5 207.6 211.7 218.2
86 289 196.3 208.0 220.6 225.1 228.3 226.5 232.7 236.4 240.4 243.0 238.3 242.7 250.3
86 290 167.6 175.9 186.1 191.0 194.3 197.3 196.5 205.9 201.0 211.0 214.7 218.8 220.1
87 291 190.2 199.6 205.7 214.2 219.5 227.6 232.5 235.5 242.5 247.5 254.2 262.8 268.1
87 292 184.0 187.7 199.3 205.4 208.4 213.6 215.6 210.7 222.6 228.9 229.1 239.3 244.2
87 293 198.4 201.1 211.7 219.7 221.6 230.5 232.1 231.2 239.8 243.8 245.9 250.8 249.3
87 294 184.5 189.1 201.9 211.7 219.0 221.9 232.1 239.6 245.3 252.2 257.3 262.3 264.0
87 295 189.4 195.4 203.9 215.5 216.0 222.9 224.2 226.9 235.7 242.4 243.8 254.2 254.9
88 296 194.7 197.1 205.6 214.5 225.4 224.5 225.1 225.1 237.5 243.5 243.8 247.2 262.6
88 297 193.2 198.4 202.4 211.9 218.1 217.0 220.9 218.3 223.7 225.3 228.8 233.2 234.1
NTP EXP/TEST: 92013-05 4-METHYLIMIDAZOLE PAGE: 11
TEST TYPE: CHRONIC INDIVIDUAL BODY WEIGHT TABLE DATE: 11/29/04
ROUTE: DOSED FEED EISRPT12 TIME: 09:48:49
----------------------------------------------------------------------------------------------------------------------------------
SPECIES-STRAIN: RATS-F 344 SEX: FEMALE TRT: 1250 PPM TRT#: 4 FIRST-DOSE: 01/20/00
----------------------------------------------------------------------------------------------------------------------------------
CAGE ANIMAL DAY ON DOSE
NO ID 118 146 174 202 230 258 286 314 342 370 398 426 454
----------------------------------------------------------------------------------------------------------------------------------
88 298 168.6 175.2 180.2 189.3 197.7 196.1 198.4 199.3 203.1 207.4 211.1 215.9 221.6
88 299 191.0 197.8 205.9 213.5 221.6 218.2 219.5 218.7 226.4 228.5 226.3 237.3 241.5
88 300 191.5 195.4 203.1 215.1 223.1 225.9 222.7 225.1 233.0 235.3 241.5 245.5 249.0
----- ----- ----- ----- ----- ----- ----- ----- ----- ----- ----- ----- -----
MEAN WT(G) 188.9 194.4 202.4 208.8 214.9 218.3 220.3 223.4 227.3 231.9 234.1 239.0 243.9
SD 9.1 9.5 10.0 10.8 11.1 12.5 12.9 14.6 15.2 15.0 14.9 16.2 16.9
NO. OBSER. 50 50 50 50 50 50 50 50 50 50 50 49 48
AVE. BODY WT
REL. TO CNTL 0.97 0.95 0.96 0.96 0.96 0.96 0.97 0.94 0.94 0.93 0.92 0.88 0.89
(TRT#: 2 )
BLANK MISSING DATA @ ANIMAL REMOVED FROM STUDY
() TRT# OF THE CONTROL GROUP USED IN CALCULATION * MULTIPLE OBSERVATIONS, LAST WEIGHT DISPLAYED
NTP EXP/TEST: 92013-05 4-METHYLIMIDAZOLE PAGE: 12
TEST TYPE: CHRONIC INDIVIDUAL BODY WEIGHT TABLE DATE: 11/29/04
ROUTE: DOSED FEED EISRPT12 TIME: 09:48:49
----------------------------------------------------------------------------------------------------------------------------------
SPECIES-STRAIN: RATS-F 344 SEX: FEMALE TRT: 1250 PPM TRT#: 4 FIRST-DOSE: 01/20/00
----------------------------------------------------------------------------------------------------------------------------------
CAGE ANIMAL DAY ON DOSE
NO ID 482 510 538 566 594 622 650 678 706
----------------------------------------------------------------------------------------------------------------------------------
79 251 242.8 240.3 248.4 254.8 248.6 251.9 260.1 260.6 259.1
79 252 232.5 232.0 235.5 238.8 234.3 238.5 246.6 252.0 246.5
79 253 268.9 274.1 276.2 280.5 280.1 287.1 291.4 294.2 299.1
79 254 288.4 289.5 291.3 291.8 294.9 302.9 305.9 309.7 322.5
79 255 237.1 233.1 235.2 240.0 231.4 230.3 230.5 225.4 236.4 @
80 256
80 257
80 258 245.8 251.9 258.1 260.3 246.7 205.6 190.6 @
80 259 245.2 238.5 249.4 253.3 259.2 266.8 273.5 283.5 282.5
80 260 226.5 234.0 244.0 246.1 249.6 249.4 255.2 256.0 257.0
81 261 246.0 244.5 250.4 258.7 263.8 266.5 274.3 276.8 280.0
81 262 240.8 246.7 248.7 252.9 258.8 260.3 267.6 271.3 275.0
81 263 254.4 249.1 252.5 252.7 252.5 260.0 266.4 264.1 267.2
81 264 229.7 226.3 230.8 239.6 233.6 237.4 243.8 239.7 248.1
81 265 269.0 270.0 278.9 288.2 295.5 279.4 @
82 266 279.2 276.4 280.1 278.4 281.2 285.8 295.0 304.7 297.7
82 267 248.1 250.5 246.4 242.6 244.1 240.4 244.6 250.3 244.9
82 268 246.3 243.7 249.9 251.7 250.3 254.5 257.4 263.0 253.8
82 269 239.3 242.2 235.7 237.6 234.2 224.6 209.9 205.8 189.0
82 270 224.3 192.6 @
83 271 265.8 267.1 273.9 275.0 271.8 276.9 278.0 283.7 287.2
83 272 276.9 282.5 294.0 292.0 294.1 298.5 300.7 305.3 306.3
83 273 246.2 247.0 257.4 260.3 261.2 261.5 265.2 269.0 269.5
83 274 231.0 232.7 246.9 241.2 235.4 239.4 241.7 252.3 246.1
83 275 250.2 252.8 265.8 259.9 259.0 261.1 264.7 272.6 269.4
84 276
84 277 278.5 238.4 243.9 239.7 248.8 250.5 251.4 253.7 262.8
84 278 245.6 240.8 250.9 247.6 256.2 261.1 264.7 263.4 267.6
84 279 232.4 235.6 241.7 242.1 252.8 255.1 256.3 254.1 252.1
84 280 243.7 248.5 251.4 249.6 256.7 258.7 261.4 261.1 266.6
85 281 219.0 223.3 233.1 232.6 238.9 236.7 220.7 248.2 249.2
85 282 209.0 210.6 214.7 215.1 218.7 222.0 228.5 238.0 239.8
85 283 258.1 257.8 266.1 265.6 269.3 252.6 268.0 @
85 284 248.2 252.9 263.3 264.7 269.4 277.1 294.5 326.7 @
85 285 238.0 246.6 245.4 244.0 245.6 243.9 251.6 257.8 255.1
86 286 266.2 267.6 267.9 262.3 262.7 268.0 271.1 277.6 283.5
86 287 232.5 235.7 234.5 238.0 242.8 240.4 242.2 246.2 247.7
86 288 220.8 219.9 219.9 223.4 225.4 222.6 226.6 223.1 229.4
86 289 264.0 264.8 260.7 268.9 283.3 270.0 252.0 240.0 236.3
86 290 226.4 232.1 235.5 240.1 239.1 241.1 242.9 246.3 251.3
87 291 266.4 276.4 280.4 284.3 293.9 296.7 304.6 303.0 279.8
87 292 263.9 273.2 279.5 284.3 282.9 290.8 290.1 284.4 @
87 293 251.4 257.8 260.6 259.0 260.7 263.6 272.3 274.9 282.5
87 294 268.1 272.1 278.6 280.7 279.6 283.6 289.7 296.7 301.0
87 295 255.0 239.6 253.4 244.9 248.1 255.9 261.3 260.9 261.2
88 296 269.8 277.1 280.5 288.5 292.0 284.0 230.1 @
88 297 234.9 240.6 243.9 240.1 245.4 245.3 252.4 249.9 258.0
NTP EXP/TEST: 92013-05 4-METHYLIMIDAZOLE PAGE: 13
TEST TYPE: CHRONIC INDIVIDUAL BODY WEIGHT TABLE DATE: 11/29/04
ROUTE: DOSED FEED EISRPT12 TIME: 09:48:49
----------------------------------------------------------------------------------------------------------------------------------
SPECIES-STRAIN: RATS-F 344 SEX: FEMALE TRT: 1250 PPM TRT#: 4 FIRST-DOSE: 01/20/00
----------------------------------------------------------------------------------------------------------------------------------
CAGE ANIMAL DAY ON DOSE
NO ID 482 510 538 566 594 622 650 678 706
----------------------------------------------------------------------------------------------------------------------------------
88 298 227.5 234.0 232.4 228.0 234.5 244.6 246.9 248.9 245.3
88 299 243.6 250.4 254.6 252.8 254.5 255.4 252.5 251.9 257.1
88 300 248.0 259.4 261.4 262.3 264.1 265.3 270.2 273.1 277.0
----- ----- ----- ----- ----- ----- ----- ----- -----
MEAN WT(G) 247.8 248.4 254.4 255.5 257.5 257.9 259.2 264.8 263.5
SD 17.9 19.6 18.4 19.0 20.0 21.8 24.8 24.9 24.3
NO. OBSER. 47 47 46 46 46 46 45 42 40
AVE. BODY WT
REL. TO CNTL 0.89 0.87 0.88 0.86 0.87 0.86 0.85 0.88 0.85
(TRT#: 2 )
BLANK MISSING DATA @ ANIMAL REMOVED FROM STUDY
() TRT# OF THE CONTROL GROUP USED IN CALCULATION * MULTIPLE OBSERVATIONS, LAST WEIGHT DISPLAYED
NTP EXP/TEST: 92013-05 4-METHYLIMIDAZOLE PAGE: 14
TEST TYPE: CHRONIC INDIVIDUAL BODY WEIGHT TABLE DATE: 11/29/04
ROUTE: DOSED FEED EISRPT12 TIME: 09:48:49
----------------------------------------------------------------------------------------------------------------------------------
SPECIES-STRAIN: RATS-F 344 SEX: FEMALE TRT: 2500 PPM TRT#: 6 FIRST-DOSE: 01/20/00
----------------------------------------------------------------------------------------------------------------------------------
CAGE ANIMAL DAY ON DOSE
NO ID 1 13 20 27 34 41 48 55 62 69 76 83 90
----------------------------------------------------------------------------------------------------------------------------------
89 301 97.6 114.8 130.5 140.7 151.9 161.2 165.0 172.7 179.4 180.6 181.8 184.0 183.1
89 302 108.7 125.3 138.4 146.9 159.0 169.1 175.2 180.5 183.3 185.5 189.2 191.7 192.6
89 303 86.4 110.7 124.5 138.5 148.8 155.7 159.6 168.2 171.4 179.1 183.3 184.4 186.0
89 304 103.9 124.3 138.1 144.7 157.3 163.8 166.6 173.9 178.0 181.0 180.2 186.4 184.8
89 305 105.2 120.5 134.1 140.8 154.3 159.9 167.4 174.8 175.7 178.0 180.3 175.3 176.8
90 306 106.4 126.1 139.9 152.8 162.7 167.8 174.0 178.1 180.8 186.2 189.7 193.0 190.3
90 307 98.6 116.0 131.2 142.5 153.0 162.0 167.5 171.1 175.0 178.2 180.1 182.2 181.0
90 308 83.3 102.7 117.7 126.4 131.9 137.9 132.9 127.8 148.8 167.6 171.8 175.3 175.0
90 309 87.9 106.3 122.2 131.8 142.3 150.8 155.3 158.2 163.2 168.6 169.9 166.8 171.3
90 310 101.0 122.7 140.0 151.0 165.3 175.6 183.3 190.4 191.3 197.1 198.5 202.5 199.0
91 311 109.9 128.9 142.3 151.5 159.0 166.7 169.0 174.7 178.7 181.4 185.2 184.3 186.6
91 312 90.6 110.2 123.4 134.4 145.1 152.2 157.3 161.1 166.6 170.5 175.3 175.7 173.1
91 313 107.4 126.1 137.7 146.2 151.8 161.6 167.1 169.6 174.0 175.0 178.3 177.9 178.8
91 314 102.9 119.3 134.2 144.1 151.4 161.8 162.2 168.4 176.2 176.3 181.8 183.0 182.9
91 315 90.6 108.2 122.4 134.8 143.9 153.1 160.2 164.9 168.7 172.8 175.7 174.6 176.3
92 316 103.8 124.8 140.7 151.0 160.4 171.1 175.1 178.3 181.7 184.1 186.9 189.0 188.9
92 317 99.4 118.2 131.9 144.8 151.8 161.5 165.6 170.7 172.8 173.4 174.7 176.4 176.5
92 318 93.8 114.8 130.0 140.5 152.2 166.5 171.4 176.2 178.6 182.2 184.8 187.4 189.3
92 319 108.1 126.1 139.2 150.4 159.0 163.2 169.2 174.5 177.9 182.4 183.2 182.9 182.4
92 320 110.1 127.3 142.1 154.5 163.6 173.8 176.5 181.0 185.8 187.8 189.4 189.8 189.8
93 321 90.9 112.9 125.2 135.1 141.8 149.7 154.0 161.8 165.2 170.3 170.9 173.8 173.7
93 322 112.3 130.3 145.8 157.4 164.9 171.5 177.6 183.2 186.5 189.1 184.5 190.8 191.6
93 323 107.3 123.6 140.1 150.9 162.5 172.2 175.1 182.6 183.1 187.7 186.5 188.9 188.9
93 324 101.6 118.6 138.0 147.8 154.1 166.3 171.3 176.5 179.4 182.5 182.8 187.0 188.0
93 325 95.2 108.5 125.4 137.7 147.3 157.7 164.2 171.0 171.9 174.3 176.6 174.2 175.6
94 326 105.4 124.8 140.6 150.8 156.9 165.7 172.9 181.3 181.9 184.4 184.4 184.7 188.0
94 327 94.7 121.8 137.9 150.4 160.8 170.8 180.1 187.1 190.2 189.3 191.2 195.0 194.0
94 328 102.8 120.5 134.2 145.7 152.6 163.5 168.7 176.0 176.6 179.8 179.1 180.6 178.5
94 329 108.3 124.8 137.7 150.6 158.9 167.7 173.4 182.5 183.3 185.6 187.3 187.9 188.3
94 330 86.4 110.5 126.6 139.4 149.3 157.5 161.0 168.9 170.2 174.1 174.4 174.6 175.2
95 331 98.1 118.3 135.4 144.3 156.1 166.5 175.6 182.2 182.8 183.7 183.9 180.6 181.8
95 332 102.3 118.5 135.7 148.6 158.7 164.9 174.5 180.6 184.5 186.3 190.1 187.6 189.2
95 333 103.7 118.2 131.5 140.4 147.3 155.8 163.2 166.2 163.6 164.9 164.8 164.7 166.2
95 334 95.7 113.4 128.1 137.9 147.4 158.1 166.6 172.3 174.0 176.8 177.9 175.8 173.5
95 335 102.7 119.0 132.9 143.7 150.9 161.1 168.6 179.2 176.7 179.4 179.6 176.3 176.4
96 336 102.6 129.6 144.3 158.0 164.9 175.3 180.4 184.0 187.0 193.3 196.6 196.6 198.2
96 337 108.1 127.5 143.4 154.6 164.4 171.5 179.4 185.5 189.3 192.2 193.8 195.5 197.1
96 338 103.0 120.2 135.4 145.0 150.4 160.0 164.4 167.7 166.6 171.8 176.4 175.3 183.1
96 339 86.2 105.6 120.9 133.8 140.7 149.0 154.3 162.6 161.4 164.8 168.7 165.8 168.0
96 340 99.0 120.3 135.6 147.3 154.0 165.8 173.7 179.8 181.6 187.6 192.0 192.1 193.4
97 341 92.9 112.1 128.1 141.4 150.5 159.3 166.1 172.4 172.7 177.5 177.1 175.9 175.0
97 342 111.9 129.2 140.9 150.3 158.8 166.1 168.8 174.1 178.6 182.2 182.3 180.0 180.6
97 343 99.9 120.4 134.8 148.0 161.0 167.7 174.2 178.7 181.5 186.1 185.1 186.4 187.3
97 344 108.6 127.6 139.0 148.5 157.5 165.4 172.4 179.3 180.2 184.7 183.7 184.2 183.7
97 345 93.0 118.0 133.6 148.5 159.2 168.2 173.2 180.6 185.1 189.1 190.0 189.3 190.4
98 346 102.8 119.5 135.7 146.7 153.3 165.0 170.3 177.8 181.8 185.5 187.1 187.7 190.0
98 347 104.5 120.1 134.7 142.6 152.1 158.7 163.5 167.3 168.7 169.5 175.8 174.4 172.9
NTP EXP/TEST: 92013-05 4-METHYLIMIDAZOLE PAGE: 15
TEST TYPE: CHRONIC INDIVIDUAL BODY WEIGHT TABLE DATE: 11/29/04
ROUTE: DOSED FEED EISRPT12 TIME: 09:48:49
----------------------------------------------------------------------------------------------------------------------------------
SPECIES-STRAIN: RATS-F 344 SEX: FEMALE TRT: 2500 PPM TRT#: 6 FIRST-DOSE: 01/20/00
----------------------------------------------------------------------------------------------------------------------------------
CAGE ANIMAL DAY ON DOSE
NO ID 1 13 20 27 34 41 48 55 62 69 76 83 90
----------------------------------------------------------------------------------------------------------------------------------
98 348 88.2 107.1 118.6 129.5 134.9 143.1 146.1 150.0 152.7 154.7 154.0 156.3 159.0
98 349 90.8 104.6 111.0 118.5 119.3 126.9 129.9 128.7 126.8 129.8 128.7 126.4 122.3 @
98 350 81.2 96.0 106.3 115.0 121.4 128.4 129.4 134.7 139.6 143.4 147.7 152.0 156.5
----- ----- ----- ----- ----- ----- ----- ----- ----- ----- ----- ----- -----
MEAN WT(G) 99.5 118.3 132.8 143.5 152.3 161.1 166.3 171.8 174.6 178.2 179.9 180.5 181.0
SD 8.1 8.0 8.5 8.9 10.0 10.4 11.8 13.2 12.4 12.0 12.0 12.6 12.6
NO. OBSER. 50 50 50 50 50 50 50 50 50 50 50 50 50
AVE. BODY WT
REL. TO CNTL 0.99 0.93 0.96 0.97 0.98 0.99 0.99 0.98 0.99 0.98 0.97 0.97 0.95
(TRT#: 2 )
BLANK MISSING DATA @ ANIMAL REMOVED FROM STUDY
() TRT# OF THE CONTROL GROUP USED IN CALCULATION * MULTIPLE OBSERVATIONS, LAST WEIGHT DISPLAYED
NTP EXP/TEST: 92013-05 4-METHYLIMIDAZOLE PAGE: 16
TEST TYPE: CHRONIC INDIVIDUAL BODY WEIGHT TABLE DATE: 11/29/04
ROUTE: DOSED FEED EISRPT12 TIME: 09:48:49
----------------------------------------------------------------------------------------------------------------------------------
SPECIES-STRAIN: RATS-F 344 SEX: FEMALE TRT: 2500 PPM TRT#: 6 FIRST-DOSE: 01/20/00
----------------------------------------------------------------------------------------------------------------------------------
CAGE ANIMAL DAY ON DOSE
NO ID 118 146 174 202 230 258 286 314 342 370 398 426 454
----------------------------------------------------------------------------------------------------------------------------------
89 301 190.7 197.0 202.2 201.8 208.4 211.2 211.2 216.3 215.2 213.1 216.8 216.4 220.1
89 302 199.3 204.5 211.9 215.1 221.8 222.0 228.3 231.7 237.9 240.1 243.2 241.8 248.7
89 303 191.0 194.4 203.3 204.9 212.7 212.9 215.4 218.3 219.6 222.1 219.2 222.2 234.1
89 304 195.0 192.0 200.0 206.2 208.7 215.9 215.6 214.6 220.4 223.9 222.1 221.2 226.3
89 305 188.9 186.1 198.9 203.2 205.0 214.3 212.7 217.8 225.5 225.6 228.6 230.6 236.4
90 306 196.3 205.0 207.1 207.3 215.6 220.6 225.1 228.8 227.1 228.6 227.3 236.8 238.0
90 307 187.4 190.1 197.6 201.9 211.9 219.6 219.1 223.8 222.2 224.5 225.9 227.5 229.4
90 308 178.0 174.1 187.5 197.0 149.8 204.8 205.3 200.3 203.3 208.7 @
90 309 174.7 181.3 189.2 191.5 201.4 202.1 205.2 208.1 208.6 208.8 211.7 217.2 221.4
90 310 205.3 212.5 219.9 225.4 237.4 239.3 243.9 245.1 250.8 251.3 250.0 254.5 262.7
91 311 191.3 193.5 198.1 205.1 212.1 208.8 214.2 212.1 219.7 218.3 218.6 222.1 225.1
91 312 179.9 180.2 191.5 198.8 203.5 206.8 208.7 211.7 214.2 212.6 214.0 217.4 222.5
91 313 186.5 193.0 206.4 210.0 222.4 219.2 230.1 229.5 230.9 233.4 236.2 240.0 245.9
91 314 187.3 188.1 199.1 203.2 207.9 210.2 216.6 215.2 219.1 222.4 216.5 219.4 228.1
91 315 182.6 186.1 194.7 199.9 205.8 208.6 210.8 211.1 214.3 214.1 214.1 218.5 226.0
92 316 204.6 205.3 214.8 217.6 224.2 227.4 234.2 231.9 233.4 239.5 237.4 240.2 248.1
92 317 207.9 193.1 198.3 200.5 203.6 204.6 202.9 205.0 208.2 207.8 202.7 206.0 207.0
92 318 206.7 206.7 210.2 216.8 219.7 226.2 228.7 229.7 231.4 235.5 237.4 240.8 239.1
92 319 199.7 207.0 205.2 210.5 214.6 217.5 225.2 225.7 229.0 234.9 228.4 230.0 235.8
92 320 207.2 198.2 209.6 216.7 218.3 217.8 224.6 221.8 228.4 223.6 227.6 226.4 233.3
93 321 181.6 188.6 197.2 204.2 210.2 213.2 218.6 216.0 220.6 224.1 227.9 234.1 235.7
93 322 199.9 206.3 212.2 215.3 224.1 225.6 225.5 220.5 226.4 233.1 234.1 242.3 248.1
93 323 196.3 199.0 204.9 211.9 219.6 217.9 224.5 215.6 226.2 226.0 225.5 230.1 230.0
93 324 190.7 196.9 205.4 202.6 210.8 211.3 215.7 217.0 222.6 225.3 216.4 222.1 223.1
93 325 185.0 188.1 198.9 203.0 209.2 207.6 206.4 210.8 212.6 215.8 217.1 221.0 224.6
94 326 193.3 191.0 204.9 203.8 206.6 211.3 208.4 211.8 215.8 222.1 223.0 218.6 223.9
94 327 195.8 205.4 216.5 220.0 221.5 226.9 229.2 231.9 237.8 241.6 241.1 241.4 244.1
94 328 181.4 185.4 195.9 199.3 196.1 203.8 202.9 208.4 212.4 213.8 211.3 219.3 219.8
94 329 188.9 195.0 207.1 206.4 209.5 214.5 210.1 209.3 211.3 217.9 222.2 226.1 228.1
94 330 179.3 183.5 196.8 197.6 198.2 204.0 204.5 207.1 207.7 217.2 213.8 215.0 221.8
95 331 187.7 201.2 207.1 207.1 219.3 218.6 217.1 227.0 223.4 226.9 227.4 232.4 233.6
95 332 192.8 202.4 213.0 210.8 219.2 221.7 216.2 225.3 227.1 228.9 229.2 230.0 235.1
95 333 173.1 182.1 190.3 189.6 195.5 199.4 196.8 203.8 206.7 212.1 214.1 216.7 216.6
95 334 184.7 193.9 194.4 198.7 205.5 206.3 206.7 214.8 214.7 219.2 217.6 217.6 220.8
95 335 180.5 189.9 198.0 206.3 209.0 212.0 214.7 218.9 223.8 223.5 222.1 224.5 227.3
96 336 203.9 210.6 213.1 189.3 222.3 226.8 228.0 226.8 236.7 238.7 240.0 241.4 239.1
96 337 200.6 213.4 222.7 205.7 238.2 240.2 240.9 239.1 249.7 252.3 255.6 260.0 259.1
96 338 184.2 193.6 199.2 183.6 214.7 215.1 216.0 210.7 214.3 216.9 221.5 220.7 220.5
96 339 176.7 186.4 187.8 163.4 192.2 199.9 198.4 198.7 206.1 206.9 205.9 206.5 207.2
96 340 193.2 204.1 209.8 181.3 224.4 224.9 227.6 221.9 232.5 233.5 235.0 232.3 235.9
97 341 181.7 184.8 195.3 200.7 185.6 214.6 214.6 212.5 217.5 222.9 225.8 227.0 228.4
97 342 181.6 187.5 200.6 204.3 204.7 216.0 213.5 221.1 223.7 231.2 232.7 237.9 242.9
97 343 191.4 195.4 201.4 204.1 204.9 215.5 218.7 217.8 221.7 224.9 229.9 231.5 233.1
97 344 185.3 188.6 196.0 200.5 188.8 213.2 214.3 217.0 222.7 211.9 221.0 220.8 223.4
97 345 197.6 198.2 208.6 211.2 196.0 228.4 224.1 223.0 231.4 232.1 230.3 235.7 234.7
98 346 191.9 197.0 208.1 218.3 226.5 230.3 231.9 235.6 238.2 239.9 237.9 248.5 250.1
98 347 178.7 182.6 192.8 197.5 202.7 203.4 209.6 208.1 212.8 216.5 212.3 224.6 228.9
NTP EXP/TEST: 92013-05 4-METHYLIMIDAZOLE PAGE: 17
TEST TYPE: CHRONIC INDIVIDUAL BODY WEIGHT TABLE DATE: 11/29/04
ROUTE: DOSED FEED EISRPT12 TIME: 09:48:49
----------------------------------------------------------------------------------------------------------------------------------
SPECIES-STRAIN: RATS-F 344 SEX: FEMALE TRT: 2500 PPM TRT#: 6 FIRST-DOSE: 01/20/00
----------------------------------------------------------------------------------------------------------------------------------
CAGE ANIMAL DAY ON DOSE
NO ID 118 146 174 202 230 258 286 314 342 370 398 426 454
----------------------------------------------------------------------------------------------------------------------------------
98 348 160.3 163.0 177.5 185.7 192.6 188.8 192.6 191.6 194.0 192.3 194.1 200.7 205.7
98 349
98 350 159.8 167.3 175.3 181.6 187.8 190.7 193.3 192.3 197.6 197.4 196.4 204.1 210.9
----- ----- ----- ----- ----- ----- ----- ----- ----- ----- ----- ----- -----
MEAN WT(G) 188.9 193.3 201.6 202.8 209.0 214.5 216.3 217.4 221.4 223.5 224.1 227.3 230.8
SD 10.9 10.8 9.8 11.3 14.7 10.7 11.5 11.2 11.9 12.3 12.6 12.5 12.5
NO. OBSER. 49 49 49 49 49 49 49 49 49 49 48 48 48
AVE. BODY WT
REL. TO CNTL 0.97 0.95 0.95 0.93 0.94 0.94 0.95 0.91 0.91 0.89 0.88 0.84 0.84
(TRT#: 2 )
BLANK MISSING DATA @ ANIMAL REMOVED FROM STUDY
() TRT# OF THE CONTROL GROUP USED IN CALCULATION * MULTIPLE OBSERVATIONS, LAST WEIGHT DISPLAYED
NTP EXP/TEST: 92013-05 4-METHYLIMIDAZOLE PAGE: 18
TEST TYPE: CHRONIC INDIVIDUAL BODY WEIGHT TABLE DATE: 11/29/04
ROUTE: DOSED FEED EISRPT12 TIME: 09:48:49
----------------------------------------------------------------------------------------------------------------------------------
SPECIES-STRAIN: RATS-F 344 SEX: FEMALE TRT: 2500 PPM TRT#: 6 FIRST-DOSE: 01/20/00
----------------------------------------------------------------------------------------------------------------------------------
CAGE ANIMAL DAY ON DOSE
NO ID 482 510 538 566 594 622 650 678 706
----------------------------------------------------------------------------------------------------------------------------------
89 301 224.0 221.1 228.0 230.5 228.7 229.5 238.6 235.8 238.3
89 302 249.9 246.7 252.8 257.9 259.6 232.2 @
89 303 233.1 229.2 235.1 232.7 233.1 241.0 245.3 243.0 251.7
89 304 225.2 225.5 226.4 229.3 230.2 239.1 239.3 244.3 251.4
89 305 241.4 235.8 241.7 248.5 247.2 248.9 245.1 237.4 234.4
90 306 240.6 242.7 248.4 257.8 262.6 258.3 272.1 266.2 275.1
90 307 229.9 233.6 241.3 241.8 237.7 243.9 249.2 244.7 236.4
90 308
90 309 220.8 223.5 228.1 235.5 241.1 244.5 246.7 250.4 244.8
90 310 266.3 265.7 273.2 272.2 273.8 274.6 285.0 294.3 296.3
91 311 226.6 224.9 228.5 242.5 231.6 232.9 239.8 239.6 235.6
91 312 226.2 224.6 229.8 231.1 246.0 242.0 248.2 251.2 250.4
91 313 223.1 248.2 249.8 254.4 258.9 258.3 261.8 267.0 260.1
91 314 228.2 225.1 227.5 232.2 239.1 235.5 223.7 @
91 315 227.1 231.6 231.1 @
92 316 257.3 238.3 240.1 205.6 @
92 317 236.1 212.1 212.8 197.3 @
92 318 206.2 256.0 260.5 264.5 270.2 274.6 281.2 280.9 282.1
92 319 236.5 237.2 247.7 254.0 253.0 265.7 269.4 272.1 276.6
92 320 233.4 232.1 233.2 233.1 231.9 238.7 251.5 249.4 255.6
93 321 239.1 242.1 253.6 256.9 256.8 259.6 265.8 273.8 273.6
93 322 246.5 227.1 231.0 254.8 257.3 265.4 271.2 277.2 246.7
93 323 228.2 229.9 231.1 237.1 226.4 245.1 244.0 242.5 274.2
93 324 220.4 223.8 226.2 227.6 236.3 234.0 240.1 246.9 254.7
93 325 221.5 226.6 226.2 229.4 229.1 236.8 237.5 235.3 272.0
94 326 224.5 225.8 224.7 229.0 227.6 227.3 @
94 327 246.1 248.5 252.5 249.0 240.9 246.0 246.3 248.1 237.5
94 328 214.0 222.9 219.5 162.1 205.2 222.4 157.9 @
94 329 228.9 232.9 233.3 235.1 238.5 215.5 @
94 330 220.5 223.8 228.7 229.7 232.1 244.7 251.0 251.0 267.1
95 331 237.0 239.0 255.0 243.7 239.7 243.9 246.8 253.2 259.3
95 332 235.4 238.3 255.0 242.2 239.5 241.1 246.6 243.8 223.0
95 333 217.5 220.4 226.0 218.4 223.8 222.2 225.1 225.7 227.7
95 334 221.0 224.0 241.1 232.1 225.4 234.8 234.7 241.4 240.2
95 335 235.3 235.0 248.0 238.4 241.7 243.7 256.0 251.5 243.7
96 336 245.0 246.8 245.1 246.1 252.3 253.5 258.9 256.8 258.6 @
96 337 267.6 267.2 268.1 269.6 271.6 274.5 276.0 227.2 @
96 338 224.9 226.4 226.7 228.3 231.8 229.8 230.9 232.4 228.8
96 339 213.7 211.6 214.7 221.1 221.1 222.2 225.0 222.3 225.1
96 340 243.6 244.2 239.9 246.8 249.2 248.7 254.5 259.2 @
97 341 226.1 228.5 227.7 227.5 234.1 242.0 244.1 253.0 253.8
97 342 244.1 243.2 250.6 251.1 259.2 270.8 275.2 292.2 302.8
97 343 231.6 245.5 241.7 241.9 240.9 @
97 344 227.9 229.4 228.4 239.2 232.7 238.0 233.1 237.5 233.8
97 345 234.0 239.0 241.1 226.8 246.5 251.1 253.5 263.9 265.1
98 346 252.2 258.2 263.2 261.0 273.9 275.4 278.6 276.3 277.2
98 347 229.2 228.9 231.9 @
NTP EXP/TEST: 92013-05 4-METHYLIMIDAZOLE PAGE: 19
TEST TYPE: CHRONIC INDIVIDUAL BODY WEIGHT TABLE DATE: 11/29/04
ROUTE: DOSED FEED EISRPT12 TIME: 09:48:49
----------------------------------------------------------------------------------------------------------------------------------
SPECIES-STRAIN: RATS-F 344 SEX: FEMALE TRT: 2500 PPM TRT#: 6 FIRST-DOSE: 01/20/00
----------------------------------------------------------------------------------------------------------------------------------
CAGE ANIMAL DAY ON DOSE
NO ID 482 510 538 566 594 622 650 678 706
----------------------------------------------------------------------------------------------------------------------------------
98 348 201.9 201.9 206.0 211.0 213.8 214.0 218.9 200.4 @
98 349
98 350 209.3 209.7 213.9 216.2 210.9 210.9 217.9 214.6 212.1
----- ----- ----- ----- ----- ----- ----- ----- -----
MEAN WT(G) 231.6 233.2 237.2 236.8 241.0 243.6 247.2 250.1 253.3
SD 13.9 13.5 14.7 19.6 16.4 16.8 22.6 20.2 21.2
NO. OBSER. 48 48 48 46 44 43 40 38 35
AVE. BODY WT
REL. TO CNTL 0.83 0.82 0.82 0.80 0.81 0.81 0.81 0.83 0.81
(TRT#: 2 )
BLANK MISSING DATA @ ANIMAL REMOVED FROM STUDY
() TRT# OF THE CONTROL GROUP USED IN CALCULATION * MULTIPLE OBSERVATIONS, LAST WEIGHT DISPLAYED
NTP EXP/TEST: 92013-05 4-METHYLIMIDAZOLE PAGE: 20
TEST TYPE: CHRONIC INDIVIDUAL BODY WEIGHT TABLE DATE: 11/29/04
ROUTE: DOSED FEED EISRPT12 TIME: 09:48:49
----------------------------------------------------------------------------------------------------------------------------------
SPECIES-STRAIN: RATS-F 344 SEX: FEMALE TRT: 5000 PPM TRT#: 8 FIRST-DOSE: 01/20/00
----------------------------------------------------------------------------------------------------------------------------------
CAGE ANIMAL DAY ON DOSE
NO ID 1 13 20 27 34 41 48 55 62 69 76 83 90
----------------------------------------------------------------------------------------------------------------------------------
99 351 92.6 91.6 110.3 122.7 134.9 144.1 152.7 158.9 161.7 159.4 162.3 165.2 170.2
99 352 99.0 87.7 99.0 104.1 109.5 112.2 114.9 115.7 112.5 114.6 114.2 116.2 119.4
99 353 103.7 98.1 106.5 113.0 121.1 123.9 131.0 135.1 135.9 137.0 136.6 138.7 142.4
99 354 101.7 98.0 110.0 121.9 131.4 137.6 140.2 148.3 146.8 150.9 149.9 152.5 154.9
99 355 104.8 108.4 124.5 133.4 141.4 149.5 156.6 162.2 164.9 168.4 169.0 170.3 172.8
100 356 95.3 89.5 99.9 106.0 115.0 120.9 125.2 131.1 132.3 136.6 131.0 131.4 135.7
100 357 108.4 105.6 121.8 133.1 141.9 149.5 154.6 158.4 159.2 164.4 163.3 166.1 170.0
100 358 91.6 89.8 103.5 114.1 124.0 134.6 138.9 144.4 145.0 147.1 145.7 147.2 153.7
100 359 105.0 103.8 115.7 125.6 137.4 146.4 153.6 158.3 157.0 159.4 157.8 159.1 160.9
100 360 100.7 101.3 115.5 124.1 134.4 140.3 146.0 150.6 151.5 154.3 152.8 154.5 160.7
101 361 99.4 99.5 114.1 119.4 127.1 130.8 131.7 131.5 132.2 135.1 134.6 137.4 142.4
101 362 93.2 96.0 104.0 109.2 115.3 120.7 126.5 128.8 126.9 127.3 133.7 139.7 147.1
101 363 82.6 82.3 93.5 101.4 105.3 107.3 109.7 113.5 111.1 112.2 112.8 117.6 121.1
101 364 99.7 101.9 114.6 125.4 130.6 141.2 143.0 149.9 146.6 151.4 152.0 151.3 155.4
101 365 107.0 106.6 117.1 125.2 133.4 141.6 145.1 153.9 153.6 154.7 156.9 160.0 163.1
102 366 107.4 108.3 123.9 130.5 137.3 144.1 151.8 154.2 157.2 161.8 161.4 165.1 170.6
102 367 101.3 106.8 117.7 125.3 133.5 141.8 143.1 145.7 152.0 154.8 156.7 158.8 161.6
102 368 104.1 101.7 117.2 129.8 135.0 143.3 152.9 159.1 161.5 162.1 162.3 166.9 169.4
102 369 97.8 95.1 114.0 123.0 136.5 147.1 151.4 156.3 161.0 164.6 165.7 168.1 171.5
102 370 87.5 91.1 102.4 110.0 118.5 125.7 130.8 133.0 137.8 141.9 141.8 145.0 149.2
103 371 82.6 79.0 92.4 99.1 105.4 108.1 112.9 116.8 117.0 117.9 118.0 118.0 123.9
103 372 107.8 103.3 111.5 117.9 126.3 130.8 133.9 137.5 141.0 141.6 140.9 142.9 144.6
103 373 95.7 90.1 108.3 119.5 131.5 137.1 141.2 149.6 149.7 154.7 153.7 155.9 155.8
103 374 100.1 97.7 107.1 113.3 119.5 122.7 120.0 122.7 127.4 128.8 126.2 124.4 127.3
103 375 88.9 83.8 94.8 98.7 105.1 110.1 112.7 113.6 118.4 121.1 119.9 117.1 118.8
104 376 87.8 84.9 100.1 115.2 123.7 132.4 141.1 144.3 146.9 148.1 142.9 151.0 153.5
104 377 103.3 94.3 113.4 126.6 133.5 141.4 149.8 160.0 160.6 166.4 164.6 168.5 174.9
104 378 104.0 100.5 111.0 117.5 126.1 134.6 137.5 137.4 142.5 142.8 148.7 147.0 152.0
104 379 110.6 104.2 117.7 127.3 137.7 143.6 150.6 156.0 157.8 160.7 161.2 159.5 160.3
104 380 90.9 91.7 102.5 111.8 121.1 129.8 135.6 145.9 144.6 144.8 146.2 150.2 151.5
105 381 97.0 82.8 113.4 121.7 130.7 139.5 146.2 149.0 154.2 152.4 154.6 154.5 159.9
105 382 103.5 101.6 117.5 118.6 138.2 146.9 153.0 159.3 161.1 158.1 158.7 161.4 163.9
105 383 103.3 95.5 102.6 109.5 119.0 123.1 126.4 133.3 136.8 138.2 140.8 146.0 151.1
105 384 89.9 91.4 104.4 111.2 114.5 119.1 123.4 130.8 132.7 131.4 132.1 134.7 140.3
105 385 102.1 99.5 115.6 126.0 132.7 141.7 145.1 150.8 154.2 154.7 157.4 157.4 162.1
106 386 104.9 100.7 105.5 118.2 122.0 128.6 133.4 143.8 145.6 145.9 148.9 154.4 157.8
106 387 92.3 92.7 107.3 121.6 131.8 139.3 146.9 154.3 153.3 158.5 156.8 161.5 161.9
106 388 100.6 96.4 106.3 116.1 120.7 127.9 133.2 135.8 137.7 139.6 142.6 141.5 144.3
106 389 104.5 100.6 114.3 124.8 132.4 137.8 141.6 135.3 141.2 147.1 157.2 154.7 154.8
106 390 91.2 91.8 103.8 112.7 121.3 133.2 137.2 142.9 144.9 149.4 150.4 152.3 156.0
107 391 103.5 94.6 106.4 114.8 120.5 130.2 133.4 139.8 143.0 147.3 148.0 152.1 155.3
107 392 108.7 103.7 118.1 130.2 140.1 145.4 150.1 155.8 159.2 156.2 163.7 168.5 170.7
107 393 96.9 88.3 103.7 109.0 113.0 115.1 114.5 116.0 117.2 121.4 124.9 128.1 127.6
107 394 87.8 81.3 90.7 98.3 104.0 106.4 112.4 115.6 117.8 115.3 120.2 126.9 132.2
107 395 101.3 102.4 115.3 114.4 116.6 117.2 119.2 123.5 126.1 125.4 130.9 133.8 133.2
108 396 96.5 90.7 102.3 107.1 117.1 122.6 125.4 132.8 130.0 132.3 132.6 137.7 134.8
108 397 110.6 105.4 122.8 134.3 140.5 150.1 150.3 156.1 159.5 163.4 162.8 167.4 168.6
NTP EXP/TEST: 92013-05 4-METHYLIMIDAZOLE PAGE: 21
TEST TYPE: CHRONIC INDIVIDUAL BODY WEIGHT TABLE DATE: 11/29/04
ROUTE: DOSED FEED EISRPT12 TIME: 09:48:49
----------------------------------------------------------------------------------------------------------------------------------
SPECIES-STRAIN: RATS-F 344 SEX: FEMALE TRT: 5000 PPM TRT#: 8 FIRST-DOSE: 01/20/00
----------------------------------------------------------------------------------------------------------------------------------
CAGE ANIMAL DAY ON DOSE
NO ID 1 13 20 27 34 41 48 55 62 69 76 83 90
----------------------------------------------------------------------------------------------------------------------------------
108 398 110.0 104.7 119.2 129.5 137.9 149.1 150.9 158.0 159.3 162.7 162.9 166.9 170.6
108 399 101.4 99.9 118.2 131.2 139.8 148.7 154.9 162.9 163.4 165.6 164.1 169.0 169.4
108 400 88.6 84.4 94.1 102.3 101.9 103.7 108.2 110.2 113.1 111.5 112.6 112.9 114.7
----- ----- ----- ----- ----- ----- ----- ----- ----- ----- ----- ----- -----
MEAN WT(G) 99.0 96.0 109.3 117.9 125.8 132.4 136.8 141.6 143.3 145.2 146.1 148.5 151.7
SD 7.4 7.8 8.6 9.8 11.2 13.1 14.1 15.3 15.5 16.1 15.9 16.3 16.4
NO. OBSER. 50 50 50 50 50 50 50 50 50 50 50 50 50
AVE. BODY WT
REL. TO CNTL 0.99 0.75 0.79 0.79 0.81 0.81 0.81 0.80 0.81 0.80 0.79 0.80 0.80
(TRT#: 2 )
BLANK MISSING DATA @ ANIMAL REMOVED FROM STUDY
() TRT# OF THE CONTROL GROUP USED IN CALCULATION * MULTIPLE OBSERVATIONS, LAST WEIGHT DISPLAYED
NTP EXP/TEST: 92013-05 4-METHYLIMIDAZOLE PAGE: 22
TEST TYPE: CHRONIC INDIVIDUAL BODY WEIGHT TABLE DATE: 11/29/04
ROUTE: DOSED FEED EISRPT12 TIME: 09:48:49
----------------------------------------------------------------------------------------------------------------------------------
SPECIES-STRAIN: RATS-F 344 SEX: FEMALE TRT: 5000 PPM TRT#: 8 FIRST-DOSE: 01/20/00
----------------------------------------------------------------------------------------------------------------------------------
CAGE ANIMAL DAY ON DOSE
NO ID 118 146 174 202 230 258 286 314 342 370 398 426 454
----------------------------------------------------------------------------------------------------------------------------------
99 351 175.4 176.9 181.3 186.9 190.6 191.5 194.4 194.2 202.1 205.5 213.8 216.0 213.0
99 352 121.2 125.9 127.4 134.6 136.0 133.5 140.2 145.4 151.0 151.2 152.1 162.6 161.1
99 353 142.9 185.6 145.5 147.2 159.2 154.6 156.5 157.0 167.3 169.3 176.7 188.9 190.0
99 354 158.5 163.2 164.8 171.8 177.4 175.7 178.6 178.7 183.6 183.5 189.1 197.2 198.5
99 355 177.1 146.9 189.5 190.8 199.4 194.4 195.1 197.2 199.4 202.0 210.5 218.3 218.4
100 356 143.8 146.8 152.9 154.1 146.1 162.1 170.4 177.6 185.8 186.9 192.2 194.8 191.1
100 357 175.8 182.4 186.8 189.7 173.5 191.9 196.7 199.9 203.2 205.8 212.2 219.6 214.0
100 358 159.8 160.7 162.6 169.9 159.0 174.7 177.6 177.1 183.1 178.7 187.5 192.3 189.4
100 359 165.2 173.2 177.0 180.6 175.9 186.3 187.8 192.5 197.9 193.9 197.2 204.0 197.4
100 360 168.9 172.5 181.0 181.2 167.2 184.8 192.7 191.0 196.5 191.7 194.9 196.8 191.0
101 361 145.8 146.9 160.7 167.9 177.5 184.9 188.2 193.7 203.7 205.7 208.9 210.9 216.1
101 362 157.7 165.6 173.7 175.6 184.4 184.7 186.2 186.9 193.2 199.3 202.4 209.7 211.7
101 363 126.5 128.7 134.1 136.1 133.4 135.2 132.6 110.4 155.0 169.2 164.4 161.0 164.2
101 364 154.6 155.0 160.9 165.2 168.0 167.3 170.6 171.7 @
101 365 167.5 169.8 175.6 180.1 185.4 185.3 185.4 185.5 189.7 188.8 188.9 195.2 193.6
102 366 167.5 173.2 180.0 178.5 187.1 185.0 185.7 187.8 193.8 197.3 202.9 203.3 203.8
102 367 160.0 166.2 177.6 173.3 184.7 183.5 183.4 184.9 190.3 189.3 196.9 201.2 200.8
102 368 169.3 170.6 184.6 182.3 189.3 189.6 188.3 190.6 192.4 196.8 196.5 196.9 203.1
102 369 172.6 177.2 183.0 181.2 190.2 188.7 189.6 191.8 190.7 192.7 194.7 197.7 200.0
102 370 150.5 154.0 164.2 164.8 172.0 172.8 174.6 177.7 184.5 188.1 192.3 198.8 203.7
103 371 120.8 123.5 128.4 136.6 143.8 142.8 146.6 146.3 153.0 160.5 165.8 176.3 181.6
103 372 142.1 149.5 157.6 155.9 173.1 173.9 176.4 177.1 182.6 194.8 201.5 206.2 216.2
103 373 155.4 162.1 168.0 173.3 178.3 175.6 181.8 182.7 182.1 188.9 194.6 199.6 198.6
103 374 124.1 126.1 131.4 137.1 145.1 136.2 139.5 142.9 143.3 144.7 150.7 153.1 156.1
103 375 121.1 126.7 136.3 132.2 144.9 134.1 141.7 148.5 148.9 158.5 160.6 168.3 175.0
104 376 154.4 160.2 166.1 168.8 173.5 177.8 183.4 183.2 185.8 196.9 133.1 172.4 202.7
104 377 174.0 181.8 182.9 187.9 192.9 195.8 196.0 196.7 191.6 198.7 192.3 198.7 199.4
104 378 159.1 156.2 168.6 172.9 177.1 180.2 183.8 184.4 188.3 183.8 193.8 200.3 202.4
104 379 161.3 163.6 165.8 174.6 185.1 191.2 195.3 193.2 188.8 199.4 189.6 198.2 193.1
104 380 154.9 164.7 169.4 175.6 180.0 185.0 189.9 192.8 195.9 209.6 204.8 211.3 211.4
105 381 164.1 163.0 168.1 173.6 178.4 181.2 184.2 186.4 193.8 188.7 194.7 198.0 194.9
105 382 169.9 174.5 179.5 188.1 197.1 200.1 207.2 202.5 204.4 205.6 211.8 212.9 209.1
105 383 159.1 163.8 167.2 171.2 176.3 178.5 181.6 183.1 181.8 188.4 187.2 194.4 194.5
105 384 144.3 145.9 156.4 160.6 164.1 174.1 181.0 187.1 185.7 197.6 195.7 203.6 200.1
105 385 164.4 163.6 171.6 171.4 176.4 182.0 184.0 190.6 189.8 191.9 197.9 204.7 206.8
106 386 164.6 168.2 174.0 179.9 187.9 196.2 201.6 200.4 205.9 201.9 204.6 207.4 209.1
106 387 166.7 164.6 174.0 177.7 183.2 181.3 182.7 186.2 188.6 195.4 190.1 200.2 202.4
106 388 148.6 152.8 156.8 160.1 170.6 172.2 176.5 180.1 184.3 189.9 191.5 195.5 196.0
106 389 156.9 159.8 168.8 166.1 175.8 180.5 183.6 193.2 199.6 @
106 390 156.8 162.7 169.9 170.4 174.6 175.5 179.6 174.1 176.9 181.5 176.1 178.8 181.3
107 391 154.6 157.9 164.2 164.3 168.2 167.3 172.2 170.9 172.5 172.8 167.1 181.5 186.7
107 392 172.7 180.2 186.9 186.2 193.2 197.3 197.6 197.7 199.8 198.4 198.2 201.2 202.8
107 393 122.5 127.4 141.8 141.7 149.5 153.0 161.4 169.1 169.4 173.6 180.5 184.9 189.9
107 394 126.8 134.3 140.2 144.0 149.0 150.9 149.5 154.4 159.7 156.9 161.3 169.5 169.0
107 395 130.8 128.3 129.3 129.7 134.5 134.9 142.1 143.0 150.4 163.8 165.6 169.8 172.1
108 396 134.0 138.7 143.5 150.2 152.8 153.6 159.4 161.5 162.8 167.5 172.2 174.1 171.1
108 397 173.3 171.7 178.6 180.3 185.9 187.7 189.8 191.0 194.5 201.1 198.8 200.1 201.0
NTP EXP/TEST: 92013-05 4-METHYLIMIDAZOLE PAGE: 23
TEST TYPE: CHRONIC INDIVIDUAL BODY WEIGHT TABLE DATE: 11/29/04
ROUTE: DOSED FEED EISRPT12 TIME: 09:48:49
----------------------------------------------------------------------------------------------------------------------------------
SPECIES-STRAIN: RATS-F 344 SEX: FEMALE TRT: 5000 PPM TRT#: 8 FIRST-DOSE: 01/20/00
----------------------------------------------------------------------------------------------------------------------------------
CAGE ANIMAL DAY ON DOSE
NO ID 118 146 174 202 230 258 286 314 342 370 398 426 454
----------------------------------------------------------------------------------------------------------------------------------
108 398 171.8 181.6 184.3 186.8 196.7 188.7 193.8 191.7 194.2 196.3 189.3 195.7 192.6
108 399 169.6 173.9 177.8 180.8 187.4 185.6 190.9 192.8 193.8 194.6 187.9 189.0 188.1
108 400 111.1 116.1 124.3 126.1 136.5 137.3 145.6 149.9 150.5 161.1 162.5 170.6 169.4
----- ----- ----- ----- ----- ----- ----- ----- ----- ----- ----- ----- -----
MEAN WT(G) 153.8 157.7 163.9 166.7 171.8 173.9 177.5 178.9 183.3 186.6 187.4 193.4 194.5
SD 17.7 18.1 18.1 17.9 18.1 19.1 18.5 19.2 17.0 16.1 18.0 15.9 15.2
NO. OBSER. 50 50 50 50 50 50 50 50 49 48 48 48 48
AVE. BODY WT
REL. TO CNTL 0.79 0.77 0.77 0.77 0.77 0.76 0.78 0.75 0.76 0.74 0.74 0.72 0.71
(TRT#: 2 )
BLANK MISSING DATA @ ANIMAL REMOVED FROM STUDY
() TRT# OF THE CONTROL GROUP USED IN CALCULATION * MULTIPLE OBSERVATIONS, LAST WEIGHT DISPLAYED
NTP EXP/TEST: 92013-05 4-METHYLIMIDAZOLE PAGE: 24
TEST TYPE: CHRONIC INDIVIDUAL BODY WEIGHT TABLE DATE: 11/29/04
ROUTE: DOSED FEED EISRPT12 TIME: 09:48:49
----------------------------------------------------------------------------------------------------------------------------------
SPECIES-STRAIN: RATS-F 344 SEX: FEMALE TRT: 5000 PPM TRT#: 8 FIRST-DOSE: 01/20/00
----------------------------------------------------------------------------------------------------------------------------------
CAGE ANIMAL DAY ON DOSE
NO ID 482 510 538 566 594 622 650 678 706
----------------------------------------------------------------------------------------------------------------------------------
99 351 221.2 215.3 218.3 223.6 220.9 219.4 217.3 217.9 221.7
99 352 166.6 169.3 172.1 174.5 169.3 168.5 189.0 163.3 @
99 353 190.4 182.9 191.4 192.2 189.6 187.6 189.1 189.1 189.4 @
99 354 202.4 202.5 206.1 202.8 203.3 203.9 212.3 211.0 213.8
99 355 220.3 213.7 216.7 214.4 203.9 208.1 188.8 204.2 199.3
100 356 195.4 196.2 201.8 201.3 199.5 200.3 202.4 207.6 209.2
100 357 221.7 222.6 226.9 229.5 224.6 229.9 226.5 226.4 226.7
100 358 198.7 200.8 201.9 205.7 206.5 208.4 205.9 205.8 207.0
100 359 201.3 205.5 175.8 @
100 360 197.1 198.4 205.7 210.5 209.0 215.0 212.5 212.8 211.3
101 361 218.6 213.3 211.2 215.7 202.5 212.6 201.4 202.3 199.8
101 362 213.6 204.6 209.3 208.1 205.4 210.2 206.6 205.4 203.8
101 363 165.9 161.5 160.5 159.0 164.4 162.3 157.5 @
101 364
101 365 193.2 190.2 192.5 192.4 184.6 189.6 192.1 195.9 196.1
102 366 206.0 210.5 225.3 225.6 219.8 226.5 224.6 234.4 230.6
102 367 192.5 192.7 134.0 @
102 368 196.1 202.5 209.2 213.6 202.7 218.5 215.6 223.0 225.9
102 369 197.4 206.1 216.4 218.9 215.7 219.5 222.6 227.5 224.4
102 370 195.2 191.3 208.2 205.2 205.1 209.8 211.2 216.9 212.3
103 371 176.5 183.4 186.8 192.5 180.6 182.5 187.0 187.2 190.9
103 372 205.3 209.5 215.0 220.9 218.9 225.8 223.7 221.1 @
103 373 188.4 196.7 203.9 203.0 202.4 208.7 209.3 211.1 218.1
103 374 151.7 165.2 165.8 172.8 160.3 168.5 @
103 375 170.8 175.7 175.3 178.0 177.0 179.5 176.5 176.1 179.9
104 376 198.7 201.6 214.7 219.9 215.7 211.9 222.1 202.9 207.3
104 377 201.7 207.7 217.2 212.8 209.9 217.3 218.6 217.8 214.8
104 378 194.5 201.5 204.2 199.9 193.3 200.8 204.1 215.3 200.4
104 379 195.2 200.0 200.3 205.1 197.7 204.9 210.3 211.6 204.4 @
104 380 206.6 216.1 188.6 @
105 381 189.1 195.2 199.2 196.1 196.4 200.7 200.4 195.5 193.5
105 382 206.2 210.6 215.3 214.0 213.9 213.6 217.4 216.9 216.1
105 383 193.6 201.3 207.1 209.3 201.8 208.9 210.9 210.7 207.0
105 384 197.5 194.1 205.5 198.7 193.3 189.7 197.1 192.9 188.4
105 385 197.8 200.6 206.1 208.4 202.3 202.3 204.1 200.9 199.2
106 386 205.7 210.1 205.1 205.0 205.2 203.9 207.0 166.7 163.0 @
106 387 197.1 203.9 206.3 210.7 207.8 208.3 214.5 214.2 218.2
106 388 193.2 198.0 196.6 201.9 201.1 194.0 196.6 198.5 196.5
106 389
106 390 176.2 180.7 186.1 188.4 187.7 193.6 199.1 198.2 196.9
107 391 177.6 188.0 190.4 190.6 188.6 194.1 197.2 173.3 160.8 @
107 392 193.7 203.2 206.8 206.3 212.0 220.4 216.9 219.6 217.1
107 393 178.0 185.3 186.1 184.7 181.3 184.9 176.6 @
107 394 161.3 163.7 169.8 173.3 165.1 166.1 169.4 171.7 @
107 395 163.2 172.6 178.6 179.9 177.5 178.3 179.2 179.3 172.9
108 396 176.3 170.1 172.8 176.2 177.9 176.7 182.8 179.4 174.8
108 397 189.2 194.8 194.3 195.8 191.3 191.8 196.4 192.2 186.0
NTP EXP/TEST: 92013-05 4-METHYLIMIDAZOLE PAGE: 25
TEST TYPE: CHRONIC INDIVIDUAL BODY WEIGHT TABLE DATE: 11/29/04
ROUTE: DOSED FEED EISRPT12 TIME: 09:48:49
----------------------------------------------------------------------------------------------------------------------------------
SPECIES-STRAIN: RATS-F 344 SEX: FEMALE TRT: 5000 PPM TRT#: 8 FIRST-DOSE: 01/20/00
----------------------------------------------------------------------------------------------------------------------------------
CAGE ANIMAL DAY ON DOSE
NO ID 482 510 538 566 594 622 650 678 706
----------------------------------------------------------------------------------------------------------------------------------
108 398 191.4 195.6 202.3 207.8 212.8 205.5 208.4 211.3 201.1
108 399 186.9 193.4 196.5 201.2 207.6 215.2 @
108 400 162.7 167.6 175.1 173.4 172.1 175.0 @
----- ----- ----- ----- ----- ----- ----- ----- -----
MEAN WT(G) 192.1 195.1 197.0 200.4 197.3 200.3 202.4 202.7 202.1
SD 16.3 15.1 18.6 16.2 16.4 17.4 16.0 17.6 17.2
NO. OBSER. 48 48 48 45 45 45 42 40 37
AVE. BODY WT
REL. TO CNTL 0.69 0.69 0.68 0.68 0.66 0.66 0.66 0.68 0.65
(TRT#: 2 )
BLANK MISSING DATA @ ANIMAL REMOVED FROM STUDY
() TRT# OF THE CONTROL GROUP USED IN CALCULATION * MULTIPLE OBSERVATIONS, LAST WEIGHT DISPLAYED
NTP EXP/TEST: 92013-05 4-METHYLIMIDAZOLE PAGE: 26
TEST TYPE: CHRONIC INDIVIDUAL BODY WEIGHT TABLE DATE: 11/29/04
ROUTE: DOSED FEED EISRPT12 TIME: 09:48:49
----------------------------------------------------------------------------------------------------------------------------------
SPECIES-STRAIN: RATS-F 344 SEX: MALE TRT: 0 PPM TRT#: 1 FIRST-DOSE: 01/20/00
----------------------------------------------------------------------------------------------------------------------------------
CAGE ANIMAL DAY ON DOSE
NO ID 1 12 19 26 33 40 47 54 61 68 75 82 89
----------------------------------------------------------------------------------------------------------------------------------
1 1 140.9 198.6 234.9 264.3 279.3 294.9 308.5 328.7 337.5 350.1 353.1 363.9 367.3
1 2 130.1 188.5 221.9 255.9 270.0 288.3 301.7 318.4 326.2 338.9 344.4 354.0 360.0
1 3 115.5 171.3 200.6 232.5 247.5 265.3 276.3 295.9 300.1 316.0 319.9 333.5 334.0
2 4 121.2 178.1 215.9 248.3 267.2 285.4 304.5 323.8 332.4 349.5 364.2 379.1 387.7
2 5 134.0 194.7 223.0 253.6 268.1 284.9 302.5 325.9 330.9 345.4 356.0 367.7 368.8
2 6 126.8 187.1 221.4 250.6 264.2 279.0 293.8 311.7 322.1 334.9 341.0 355.9 353.0
3 7 105.7 160.2 196.7 234.5 249.8 267.5 277.3 303.9 312.0 328.4 331.1 342.0 345.1
3 8 138.5 196.0 225.5 259.1 274.4 289.4 299.3 318.9 323.1 335.6 337.3 350.8 352.9
3 9 120.4 173.5 207.0 239.1 248.9 267.3 280.9 297.1 311.6 324.3 328.6 344.0 345.6
4 10 134.7 196.6 232.2 266.8 283.4 303.3 320.9 338.1 346.9 362.5 367.2 381.2 382.8
4 11 129.8 188.8 220.5 257.5 272.0 290.9 306.4 327.8 335.4 349.0 363.4 374.8 379.6
4 12 115.5 172.8 204.4 240.0 254.3 271.2 284.3 305.1 318.2 327.6 336.3 343.5 343.9
5 13 121.9 172.4 199.4 224.9 242.3 259.2 271.8 286.8 295.2 306.2 311.1 322.2 322.0
5 14 112.5 168.7 197.1 219.2 233.4 247.1 260.3 276.8 283.5 297.3 302.9 314.4 320.5
5 15 119.3 174.7 204.4 234.8 248.5 265.5 279.5 294.2 300.2 312.3 321.8 330.8 331.8
6 16 131.3 179.5 199.7 223.2 234.1 248.3 262.9 279.0 286.7 299.8 306.1 320.1 321.7
6 17 115.3 166.1 190.9 217.8 229.8 244.6 260.2 278.4 281.6 295.9 305.2 319.4 320.3
6 18 142.3 201.2 229.8 258.9 268.3 287.6 302.5 315.6 323.2 338.2 344.4 358.6 361.5
7 19 131.4 190.7 224.4 256.4 266.2 285.7 304.3 323.9 329.3 339.6 345.7 359.6 364.9
7 20 117.3 171.3 205.4 232.9 246.9 265.6 281.9 299.4 306.5 318.5 324.4 342.6 345.6
7 21 129.2 184.8 215.3 247.1 259.0 276.4 290.0 312.6 315.9 330.7 337.2 348.4 346.3
8 22 130.6 188.3 221.4 251.7 268.1 287.5 301.1 317.6 329.8 342.6 349.4 354.2 355.1
8 23 131.1 166.0 211.8 243.4 259.7 276.4 285.5 302.1 308.3 315.6 316.8 324.0 329.6
8 24 119.6 174.1 209.1 241.8 258.0 278.4 294.4 318.1 333.6 339.1 345.8 360.0 366.4
9 25 130.1 190.9 220.8 248.3 264.8 241.0 288.8 314.0 323.9 333.9 336.7 352.5 349.9
9 26 107.3 151.9 174.0 197.2 205.8 186.4 221.8 239.1 250.1 258.7 264.4 274.6 282.4
9 27 121.6 182.7 219.1 250.6 268.3 246.8 289.9 312.8 322.5 329.8 338.4 353.0 363.3
10 28 121.7 176.1 202.8 228.7 241.7 257.3 270.6 287.6 294.1 303.0 310.1 325.2 330.5
10 29 117.1 169.3 196.9 223.0 236.2 256.5 272.8 292.8 300.2 312.2 317.2 332.8 335.5
10 30 135.8 188.5 213.0 240.7 254.3 273.4 282.4 300.0 310.6 322.8 328.0 339.6 343.9
11 31 124.1 183.5 216.0 248.8 257.5 276.1 286.9 311.9 320.9 329.8 331.3 342.2 349.4
11 32 102.0 152.1 183.5 211.0 226.0 241.5 256.0 274.5 289.2 301.1 303.5 318.5 323.8
11 33 133.6 188.8 216.2 244.6 255.0 271.8 288.7 302.1 315.5 329.1 332.3 347.7 351.4
12 34 119.2 166.8 194.8 223.7 236.3 251.2 269.0 285.1 294.7 305.8 308.3 320.2 326.8
12 35 113.8 169.4 202.2 234.2 249.3 266.4 285.3 303.5 316.2 331.6 341.0 342.3 347.8
12 36 127.8 186.9 216.3 248.2 264.6 283.9 302.0 320.9 332.6 336.3 337.1 346.3 354.9
13 37 126.8 187.8 217.4 249.1 268.7 283.8 300.8 319.0 328.4 331.3 326.8 339.8 344.7
13 38 132.6 182.9 217.8 256.1 271.6 290.8 307.6 320.1 329.5 338.6 343.4 361.2 366.9
13 39 123.2 177.1 200.0 228.1 243.9 258.7 272.6 286.7 293.5 300.8 306.8 321.8 322.4
14 40 134.2 190.4 222.2 252.8 269.8 287.3 305.3 319.1 330.4 343.5 335.4 356.4 363.8
14 41 125.8 184.9 209.2 242.6 260.0 274.8 287.3 300.7 312.1 318.2 320.3 328.4 331.8
14 42 112.2 168.2 201.1 234.5 250.4 266.3 280.6 299.2 313.7 321.7 322.8 338.1 339.8
15 43 118.1 179.3 214.5 247.6 262.3 283.8 300.8 317.6 333.0 340.7 348.2 356.7 362.1
15 44 105.4 164.2 198.5 231.3 247.5 266.1 283.9 302.0 307.6 313.1 320.2 330.0 334.8
15 45 134.0 187.4 212.3 238.2 254.5 268.3 285.1 301.4 313.0 320.8 325.7 335.5 338.0
16 46 141.6 190.4 214.3 243.3 261.7 273.9 283.9 298.9 308.8 317.1 319.1 328.2 329.1
16 47 124.8 180.3 211.8 243.9 259.6 273.7 285.5 300.7 307.1 316.4 325.7 334.3 339.4
NTP EXP/TEST: 92013-05 4-METHYLIMIDAZOLE PAGE: 27
TEST TYPE: CHRONIC INDIVIDUAL BODY WEIGHT TABLE DATE: 11/29/04
ROUTE: DOSED FEED EISRPT12 TIME: 09:48:49
----------------------------------------------------------------------------------------------------------------------------------
SPECIES-STRAIN: RATS-F 344 SEX: MALE TRT: 0 PPM TRT#: 1 FIRST-DOSE: 01/20/00
----------------------------------------------------------------------------------------------------------------------------------
CAGE ANIMAL DAY ON DOSE
NO ID 1 12 19 26 33 40 47 54 61 68 75 82 89
----------------------------------------------------------------------------------------------------------------------------------
16 48 125.9 174.0 201.4 232.7 248.5 259.8 276.1 296.2 306.3 318.3 325.6 338.5 344.4
17 49 115.8 172.4 199.2 234.9 250.4 269.3 279.6 299.6 310.4 320.8 327.6 340.4 343.8
17 50 118.3 170.4 202.4 231.3 248.5 267.5 282.4 302.8 311.5 320.8 328.9 335.7 338.5
----- ----- ----- ----- ----- ----- ----- ----- ----- ----- ----- ----- -----
MEAN WT(G) 124.2 179.2 209.8 240.4 255.0 269.7 285.9 304.2 313.3 324.3 329.6 341.7 345.3
SD 9.7 11.5 12.4 14.1 14.9 19.1 17.0 17.5 17.8 18.1 18.6 18.9 19.0
NO. OBSER. 50 50 50 50 50 50 50 50 50 50 50 50 50
BLANK MISSING DATA @ ANIMAL REMOVED FROM STUDY
() TRT# OF THE CONTROL GROUP USED IN CALCULATION * MULTIPLE OBSERVATIONS, LAST WEIGHT DISPLAYED
NTP EXP/TEST: 92013-05 4-METHYLIMIDAZOLE PAGE: 28
TEST TYPE: CHRONIC INDIVIDUAL BODY WEIGHT TABLE DATE: 11/29/04
ROUTE: DOSED FEED EISRPT12 TIME: 09:48:49
----------------------------------------------------------------------------------------------------------------------------------
SPECIES-STRAIN: RATS-F 344 SEX: MALE TRT: 0 PPM TRT#: 1 FIRST-DOSE: 01/20/00
----------------------------------------------------------------------------------------------------------------------------------
CAGE ANIMAL DAY ON DOSE
NO ID 117 145 173 201 229 257 285 313 341 369 397 425 453
----------------------------------------------------------------------------------------------------------------------------------
1 1 380.7 393.4 403.8 422.9 430.0 428.8 440.6 442.1 442.5 449.4 451.2 443.9 448.6
1 2 385.8 404.5 413.0 430.7 437.2 435.3 446.8 446.5 448.1 456.2 458.2 454.1 465.6
1 3 351.7 366.4 377.3 398.0 403.5 405.8 414.3 418.3 409.7 420.9 421.4 417.8 427.3
2 4 406.5 421.9 432.3 452.5 445.3 469.3 475.1 469.4 465.6 470.7 471.6 472.6 487.4
2 5 382.7 399.5 414.0 430.4 429.7 447.8 454.3 452.9 452.6 456.6 456.1 452.1 455.3
2 6 376.0 386.6 407.0 412.1 417.4 433.8 438.3 446.6 441.8 445.7 451.2 450.8 455.8
3 7 364.8 379.6 397.3 412.6 410.9 427.2 430.8 428.8 439.1 440.3 438.3 444.8 456.5
3 8 369.7 392.5 408.2 426.7 434.0 451.7 453.3 448.8 454.9 466.9 468.3 463.3 475.8
3 9 364.2 381.5 391.6 407.9 415.7 425.8 428.9 428.5 434.1 436.1 443.8 448.3 475.7
4 10 405.2 425.6 443.9 466.5 471.8 478.7 479.8 470.6 481.3 480.2 477.5 489.0 491.4
4 11 403.8 415.2 435.1 444.6 459.9 465.9 467.9 470.4 472.7 476.5 476.7 485.5 487.4
4 12 362.2 392.9 408.4 418.1 434.9 441.5 441.8 445.0 457.0 453.7 455.9 457.5 454.6
5 13 333.6 359.9 367.9 382.7 390.8 394.9 397.5 405.0 410.4 411.4 412.0 423.8 422.9
5 14 344.2 366.2 380.3 394.8 401.4 415.4 414.1 425.1 428.8 428.2 430.8 443.4 453.4
5 15 346.0 361.0 382.8 397.2 403.7 406.8 412.6 411.8 418.1 420.4 427.0 441.8 445.7
6 16 350.9 372.0 388.0 403.8 418.1 411.1 423.2 427.6 428.0 430.2 427.4 434.2 434.6
6 17 350.6 374.6 378.9 396.2 405.0 399.7 406.9 414.4 412.3 419.3 420.0 428.0 436.6
6 18 383.3 407.0 412.6 419.9 430.2 428.9 432.8 434.9 431.8 432.9 433.0 449.1 454.2
7 19 390.8 405.4 405.4 412.3 437.0 439.2 435.6 445.6 444.8 442.1 429.9 438.1 439.5
7 20 360.3 374.2 373.3 393.2 410.4 417.9 414.0 424.9 429.4 421.9 416.2 428.2 438.3
7 21 365.1 387.7 391.5 409.4 415.8 425.5 423.6 433.4 428.1 431.7 425.6 428.3 436.2
8 22 363.6 381.9 397.5 414.3 429.7 433.9 435.1 460.1 442.7 450.6 449.5 455.4 455.1
8 23 347.0 370.0 370.0 387.2 392.6 393.2 400.9 407.1 405.1 405.8 401.8 411.5 419.9
8 24 382.2 400.7 410.4 426.4 431.3 445.0 449.6 457.4 456.2 460.9 465.5 474.8 484.2
9 25 366.9 392.1 401.0 413.7 421.8 433.8 435.4 438.3 438.2 436.2 431.5 444.7 452.7
9 26 302.6 329.9 335.9 355.9 364.8 377.2 380.7 386.4 391.0 396.2 391.9 400.3 408.6
9 27 369.9 404.6 403.9 420.7 429.7 446.1 447.8 457.3 462.3 468.8 465.2 478.8 488.7
10 28 345.4 367.9 382.6 396.9 403.3 415.0 421.1 431.2 432.3 423.9 428.8 439.4 436.0
10 29 342.7 364.5 378.5 387.1 387.0 399.6 400.7 408.3 413.8 405.6 413.0 421.8 395.9
10 30 373.6 385.3 403.4 413.4 426.1 437.2 443.6 455.5 456.2 455.7 461.9 471.6 474.1
11 31 370.0 381.7 402.2 421.0 433.1 435.4 437.5 447.2 453.4 452.9 454.9 461.2 470.4
11 32 351.8 370.3 385.9 396.5 403.7 409.7 413.6 418.4 424.6 414.6 412.4 418.3 421.1
11 33 376.9 383.5 406.1 419.3 430.6 443.1 439.9 448.3 446.7 443.2 446.9 453.1 462.1
12 34 353.1 367.6 375.8 386.6 395.3 399.0 400.1 397.3 402.6 402.8 406.9 413.8 416.8
12 35 371.1 385.5 393.5 411.8 429.6 430.9 433.7 437.5 438.5 441.5 443.3 452.4 459.2
12 36 376.9 396.3 414.7 437.8 446.5 448.2 447.4 440.6 451.7 455.0 459.0 465.1 467.5
13 37 358.9 375.2 393.8 409.9 412.5 422.0 417.1 422.3 430.8 434.2 437.4 443.0 447.8
13 38 385.1 399.0 423.0 445.7 449.6 462.6 458.9 453.8 467.7 467.8 474.7 483.2 478.3
13 39 349.3 359.8 379.8 391.3 389.2 397.6 395.9 402.2 404.1 497.6 406.9 406.1 403.0
14 40 383.6 375.1 395.4 416.1 424.7 438.9 436.7 431.4 457.4 457.2 451.3 467.3 471.3
14 41 352.5 360.7 368.8 382.2 380.6 388.4 380.6 379.3 393.0 384.8 376.7 393.8 397.0
14 42 371.2 373.0 388.2 408.8 413.2 426.1 428.9 426.5 446.8 440.2 441.4 451.3 456.5
15 43 386.3 405.3 420.0 429.7 434.8 442.8 444.2 444.6 457.7 460.7 456.8 461.2 465.4
15 44 356.8 372.2 386.0 403.9 403.5 412.3 422.0 432.1 435.9 439.3 437.8 443.8 451.9
15 45 356.4 377.4 392.5 401.9 402.6 416.9 421.5 423.7 434.7 430.6 430.3 433.5 435.2
16 46 339.4 348.7 371.5 384.1 390.1 407.7 409.8 411.5 421.7 424.6 417.6 431.9 434.7
16 47 357.3 375.3 390.4 409.2 416.5 421.5 430.4 433.8 442.9 441.6 435.8 445.4 450.6
NTP EXP/TEST: 92013-05 4-METHYLIMIDAZOLE PAGE: 29
TEST TYPE: CHRONIC INDIVIDUAL BODY WEIGHT TABLE DATE: 11/29/04
ROUTE: DOSED FEED EISRPT12 TIME: 09:48:49
----------------------------------------------------------------------------------------------------------------------------------
SPECIES-STRAIN: RATS-F 344 SEX: MALE TRT: 0 PPM TRT#: 1 FIRST-DOSE: 01/20/00
----------------------------------------------------------------------------------------------------------------------------------
CAGE ANIMAL DAY ON DOSE
NO ID 117 145 173 201 229 257 285 313 341 369 397 425 453
----------------------------------------------------------------------------------------------------------------------------------
16 48 362.7 372.6 398.2 402.1 405.3 421.9 423.0 424.0 439.4 433.6 427.7 432.0 432.3
17 49 369.4 390.6 398.9 416.8 424.7 435.0 443.2 453.7 469.0 438.3 456.6 465.2 400.4 @
17 50 361.0 378.9 385.3 397.0 402.1 401.9 408.4 416.2 419.6 418.9 420.7 418.6 418.5
----- ----- ----- ----- ----- ----- ----- ----- ----- ----- ----- ----- -----
MEAN WT(G) 365.2 382.3 395.3 410.4 417.5 425.9 428.8 432.7 437.3 439.5 437.9 444.7 448.0
SD 19.2 18.6 19.4 20.0 20.9 21.8 21.8 20.9 21.0 22.8 22.8 22.2 25.1
NO. OBSER. 50 50 50 50 50 50 50 50 50 50 50 50 50
BLANK MISSING DATA @ ANIMAL REMOVED FROM STUDY
() TRT# OF THE CONTROL GROUP USED IN CALCULATION * MULTIPLE OBSERVATIONS, LAST WEIGHT DISPLAYED
NTP EXP/TEST: 92013-05 4-METHYLIMIDAZOLE PAGE: 30
TEST TYPE: CHRONIC INDIVIDUAL BODY WEIGHT TABLE DATE: 11/29/04
ROUTE: DOSED FEED EISRPT12 TIME: 09:48:49
----------------------------------------------------------------------------------------------------------------------------------
SPECIES-STRAIN: RATS-F 344 SEX: MALE TRT: 0 PPM TRT#: 1 FIRST-DOSE: 01/20/00
----------------------------------------------------------------------------------------------------------------------------------
CAGE ANIMAL DAY ON DOSE
NO ID 481 509 537 565 593 621 649 677 705
----------------------------------------------------------------------------------------------------------------------------------
1 1 434.8 437.2 430.7 438.3 440.2 437.7 434.9 433.0 424.3
1 2 461.8 455.3 452.7 445.9 437.4 436.9 433.3 429.5 421.3
1 3 428.4 424.3 425.3 431.4 418.5 414.0 410.6 409.7 374.9 @
2 4 482.3 478.3 482.3 478.2 481.3 478.9 474.9 478.7 451.4
2 5 451.7 450.2 447.4 448.7 447.1 444.7 436.0 432.2 @
2 6 456.3 451.2 444.8 446.6 448.7 446.7 457.7 @
3 7 444.0 438.8 439.1 435.9 418.5 422.2 420.2 416.2 295.1 @
3 8 470.1 472.4 473.4 467.6 459.7 462.5 464.3 455.1 443.0
3 9 428.6 431.7 427.2 414.8 414.5 410.1 375.9 @
4 10 495.1 485.7 469.4 478.5 464.3 420.5 391.4 329.5 @
4 11 488.1 481.6 470.6 476.9 473.5 471.5 458.3 420.4 @
4 12 452.6 486.3 433.7 450.4 430.8 366.3 @
5 13 427.9 416.5 415.9 424.5 417.8 309.4 403.6 396.5 394.9
5 14 454.8 463.4 449.3 431.9 424.0 315.2 388.0 298.8 @
5 15 444.6 431.7 430.1 423.9 423.4 314.5 415.1 406.1 403.5
6 16 445.8 444.1 438.7 441.7 433.1 423.8 425.6 416.0 430.4
6 17 438.7 433.9 426.8 413.2 409.3 400.0 407.5 402.0 405.2 @
6 18 457.0 450.7 453.1 448.7 446.2 435.2 430.8 423.9 428.1
7 19 436.7 442.7 441.7 440.7 441.9 423.7 421.9 425.2 374.2
7 20 433.9 426.0 428.6 430.4 428.8 427.8 427.3 424.1 419.1
7 21 429.1 408.3 415.7 421.0 426.8 429.3 436.6 452.3 437.9
8 22 455.2 444.3 452.7 435.8 435.6 420.4 423.3 425.6 410.3
8 23 421.6 416.4 393.2 @
8 24 477.3 466.6 469.7 462.6 457.0 446.9 439.9 436.5 428.3
9 25 442.4 431.9 431.6 430.0 430.3 411.3 416.4 423.8 324.2
9 26 405.6 399.0 398.7 401.0 392.7 382.7 387.7 385.2 293.5
9 27 480.2 474.8 476.2 473.3 467.9 452.9 460.7 470.0 369.9
10 28 431.3 424.9 426.5 418.8 @
10 29 410.4 400.6 400.5 363.5 333.0 @
10 30 474.2 463.9 465.9 464.9 453.3 428.3 424.3 411.2 401.3
11 31 458.6 453.2 458.8 457.6 452.9 447.8 451.9 445.4 441.6
11 32 415.1 404.6 408.6 406.4 402.1 395.6 398.6 391.3 386.2
11 33 452.1 447.0 450.0 453.6 451.1 456.1 462.2 465.5 462.6
12 34 413.2 408.3 399.4 404.9 412.7 408.5 410.2 417.8 412.2
12 35 460.3 455.9 457.1 463.8 469.2 478.1 501.0 506.5 @
12 36 462.5 450.2 448.6 450.8 446.4 444.5 443.9 438.1 436.7
13 37 448.2 441.5 441.1 443.9 441.2 444.3 451.6 452.1 401.7
13 38 472.7 467.7 469.8 472.4 465.1 466.1 462.9 454.2 392.8
13 39 406.5 499.1 398.4 398.9 396.5 397.9 402.4 400.0 337.4 @
14 40 460.4 470.8 470.5 477.7 474.1 479.3 486.3 492.1 500.5
14 41 384.2 386.9 383.2 376.0 376.2 374.3 378.4 379.2 380.6
14 42 454.9 458.1 454.5 448.2 446.6 441.9 441.3 441.0 439.4
15 43 462.5 465.9 484.4 498.7 @
15 44 439.6 435.9 431.8 430.9 430.5 420.9 424.2 425.5 420.6
15 45 435.6 424.6 410.9 401.9 394.9 392.6 384.4 384.2 375.7
16 46 435.8 433.1 424.3 427.5 425.5 421.2 331.3 @
16 47 452.7 457.0 444.7 430.9 446.1 432.0 427.7 420.3 401.0
NTP EXP/TEST: 92013-05 4-METHYLIMIDAZOLE PAGE: 31
TEST TYPE: CHRONIC INDIVIDUAL BODY WEIGHT TABLE DATE: 11/29/04
ROUTE: DOSED FEED EISRPT12 TIME: 09:48:49
----------------------------------------------------------------------------------------------------------------------------------
SPECIES-STRAIN: RATS-F 344 SEX: MALE TRT: 0 PPM TRT#: 1 FIRST-DOSE: 01/20/00
----------------------------------------------------------------------------------------------------------------------------------
CAGE ANIMAL DAY ON DOSE
NO ID 481 509 537 565 593 621 649 677 705
----------------------------------------------------------------------------------------------------------------------------------
16 48 434.9 434.4 432.4 429.8 430.0 426.9 423.1 405.2 307.0 @
17 49
17 50 408.3 403.4 394.4 402.5 394.1 390.6 387.4 384.2 380.9
----- ----- ----- ----- ----- ----- ----- ----- -----
MEAN WT(G) 445.3 443.5 438.3 437.8 432.8 421.2 425.8 422.1 400.2
SD 23.4 25.7 25.7 27.8 28.4 39.7 32.5 38.2 45.9
NO. OBSER. 49 49 49 48 46 45 44 41 36
BLANK MISSING DATA @ ANIMAL REMOVED FROM STUDY
() TRT# OF THE CONTROL GROUP USED IN CALCULATION * MULTIPLE OBSERVATIONS, LAST WEIGHT DISPLAYED
NTP EXP/TEST: 92013-05 4-METHYLIMIDAZOLE PAGE: 32
TEST TYPE: CHRONIC INDIVIDUAL BODY WEIGHT TABLE DATE: 11/29/04
ROUTE: DOSED FEED EISRPT12 TIME: 09:48:49
----------------------------------------------------------------------------------------------------------------------------------
SPECIES-STRAIN: RATS-F 344 SEX: MALE TRT: 625 PPM TRT#: 3 FIRST-DOSE: 01/20/00
----------------------------------------------------------------------------------------------------------------------------------
CAGE ANIMAL DAY ON DOSE
NO ID 1 12 19 26 33 40 47 54 61 68 75 82 89
----------------------------------------------------------------------------------------------------------------------------------
18 51 118.8 165.7 195.5 224.2 241.0 254.5 268.3 283.0 288.0 299.8 303.5 315.0 324.6
18 52 141.1 193.7 222.3 253.7 268.7 282.5 295.5 312.6 320.3 331.3 331.5 341.6 343.0
18 53 139.6 196.5 230.2 264.9 283.1 296.9 310.0 327.4 338.8 352.0 357.5 368.7 376.5
19 54 125.5 188.2 222.8 254.6 273.7 289.9 304.9 321.7 334.7 339.0 341.7 351.7 351.9
19 55 124.6 173.1 198.9 227.3 243.2 256.3 267.6 283.4 294.6 298.5 304.5 309.5 310.6
19 56 108.3 159.1 192.2 226.3 247.2 260.6 276.5 297.8 310.6 320.3 320.2 334.4 340.0
20 57 127.0 172.9 202.6 233.0 250.8 264.8 278.8 299.1 310.4 318.0 321.3 331.2 330.3
20 58 111.6 160.5 188.4 221.1 236.1 250.4 260.1 274.9 282.0 292.0 299.5 311.0 311.6
20 59 122.7 177.4 210.2 242.7 259.5 277.8 287.1 303.4 314.9 324.3 328.0 338.3 334.3
21 60 103.3 154.6 189.0 218.2 236.3 250.7 265.8 280.9 290.8 295.2 301.3 311.6 308.6
21 61 137.5 191.1 221.0 246.7 265.9 283.3 294.1 314.5 321.3 329.0 335.1 344.6 343.0
21 62 105.3 153.8 182.7 213.8 231.7 248.3 261.7 277.9 289.2 296.9 302.7 310.9 313.0
22 63 121.6 171.3 203.5 230.6 252.1 265.9 281.7 301.1 313.0 324.1 325.3 335.0 337.8
22 64 119.3 170.3 203.5 233.4 253.0 272.7 285.5 305.8 313.2 323.9 326.2 334.9 333.0
22 65 133.3 180.0 207.7 234.8 251.6 263.4 276.6 291.8 302.7 312.8 314.1 320.1 317.2
23 66 111.7 161.4 190.2 218.5 225.4 238.9 251.7 270.0 285.9 295.7 299.0 307.9 314.8
23 67 119.9 172.0 202.7 232.5 248.1 274.2 282.2 300.5 314.6 322.1 327.4 333.2 340.9
23 68 130.3 183.1 222.2 252.1 269.2 285.9 304.0 322.4 329.1 342.5 344.0 360.7 360.6
24 69 141.2 194.8 226.2 258.6 276.7 293.5 310.7 329.6 341.2 348.9 353.9 368.4 375.9
24 70 133.3 178.8 209.0 238.4 253.3 275.3 290.7 311.0 320.7 335.6 339.7 347.2 352.4
24 71 124.3 178.4 206.0 234.4 251.3 263.7 275.0 296.5 301.0 305.0 314.8 324.6 328.2
25 72 104.1 153.9 187.2 218.5 235.6 252.9 263.2 278.5 286.4 293.2 297.6 300.0 309.0
25 73 114.7 167.3 202.5 232.1 250.8 265.8 280.1 296.5 306.9 317.8 322.4 323.3 328.7
25 74 120.8 175.0 208.4 231.8 244.3 260.5 274.5 292.0 303.4 310.1 317.1 320.6 320.2
26 75 124.6 171.7 201.1 229.1 241.2 257.2 271.7 290.0 299.9 310.5 311.7 318.6 319.8
26 76 124.3 171.5 203.4 231.7 247.7 263.3 278.6 295.4 301.0 305.9 305.7 310.2 315.2
26 77 107.3 150.1 178.6 204.5 215.5 226.0 237.9 255.7 263.3 273.8 272.5 276.8 283.3
27 78 130.0 179.8 213.4 247.7 266.3 284.8 299.4 315.2 326.3 335.0 344.3 356.3 365.5
27 79 137.7 184.3 211.0 237.8 248.1 258.8 265.2 279.4 289.2 300.0 305.7 315.1 320.7
27 80 119.4 162.2 189.5 215.4 231.5 248.8 263.4 277.0 285.8 293.3 299.6 310.5 309.7
28 81 139.6 193.4 226.8 260.6 274.9 292.9 308.0 329.5 337.9 350.4 356.1 365.4 353.6
28 82 116.9 162.4 194.3 223.3 238.2 254.4 266.7 288.1 302.7 312.4 321.7 328.9 332.1
28 83 121.9 173.6 207.4 242.9 259.6 280.0 294.5 313.6 328.8 340.1 341.9 351.8 343.7
29 84 135.5 188.8 221.8 253.7 264.9 277.2 289.9 308.3 314.9 326.6 328.0 338.0 337.6
29 85 119.6 177.9 218.6 255.6 277.2 298.6 316.7 342.7 355.8 370.6 375.2 391.2 398.8
29 86 139.0 184.2 211.8 239.2 251.6 263.3 276.2 290.5 297.9 310.2 309.6 320.1 319.2
30 87 112.6 162.1 196.1 227.2 239.9 257.2 279.7 295.2 300.5 311.0 317.8 329.2 330.2
30 88 128.5 176.7 205.0 237.9 252.7 267.7 288.0 305.0 311.1 322.7 332.6 344.1 342.7
30 89 123.7 166.9 194.3 225.1 235.0 245.0 265.8 280.5 288.6 306.7 313.8 320.7 322.1
31 90 105.2 150.4 183.0 214.2 229.7 247.8 259.2 276.5 282.3 294.0 297.0 304.7 302.7
31 91 143.9 188.2 216.2 246.4 257.7 272.7 285.1 299.3 310.6 326.8 327.3 332.2 300.4
31 92 137.9 194.3 223.8 259.8 275.0 291.2 309.4 326.0 333.8 345.5 347.6 363.2 360.8
32 93 120.3 168.9 202.8 231.8 246.5 259.3 269.4 281.3 289.6 298.0 301.8 309.6 314.6
32 94 113.6 160.8 191.3 220.5 235.3 251.1 263.8 281.5 291.0 304.4 309.6 321.0 322.2
32 95 126.2 172.9 201.4 228.9 241.6 259.6 270.5 287.3 296.6 306.0 309.5 318.7 318.8
33 96 119.0 168.4 199.5 231.7 247.8 262.2 278.1 294.6 306.8 324.0 314.7 335.1 320.7
33 97 136.6 186.7 213.1 247.0 261.2 281.4 295.2 313.9 323.9 334.5 340.6 348.0 349.2
NTP EXP/TEST: 92013-05 4-METHYLIMIDAZOLE PAGE: 33
TEST TYPE: CHRONIC INDIVIDUAL BODY WEIGHT TABLE DATE: 11/29/04
ROUTE: DOSED FEED EISRPT12 TIME: 09:48:49
----------------------------------------------------------------------------------------------------------------------------------
SPECIES-STRAIN: RATS-F 344 SEX: MALE TRT: 625 PPM TRT#: 3 FIRST-DOSE: 01/20/00
----------------------------------------------------------------------------------------------------------------------------------
CAGE ANIMAL DAY ON DOSE
NO ID 1 12 19 26 33 40 47 54 61 68 75 82 89
----------------------------------------------------------------------------------------------------------------------------------
33 98 124.3 171.1 202.9 229.5 239.0 253.8 268.8 288.5 297.8 308.1 313.3 323.0 338.3
34 99 126.0 175.1 205.9 234.8 248.0 265.2 277.6 293.4 305.1 317.8 323.4 339.2 340.3
34 100 106.7 156.9 188.1 219.4 234.2 253.3 266.8 279.0 287.2 301.5 303.0 316.2 314.6
----- ----- ----- ----- ----- ----- ----- ----- ----- ----- ----- ----- -----
MEAN WT(G) 123.6 173.4 204.5 234.8 250.2 266.0 279.8 297.2 306.8 317.2 321.0 330.6 331.7
SD 11.1 12.5 12.9 14.0 15.0 16.0 16.9 18.1 18.7 19.4 19.5 21.3 21.7
NO. OBSER. 50 50 50 50 50 50 50 50 50 50 50 50 50
AVE. BODY WT
REL. TO CNTL 1.00 0.97 0.97 0.98 0.98 0.99 0.98 0.98 0.98 0.98 0.97 0.97 0.96
(TRT#: 1 )
BLANK MISSING DATA @ ANIMAL REMOVED FROM STUDY
() TRT# OF THE CONTROL GROUP USED IN CALCULATION * MULTIPLE OBSERVATIONS, LAST WEIGHT DISPLAYED
NTP EXP/TEST: 92013-05 4-METHYLIMIDAZOLE PAGE: 34
TEST TYPE: CHRONIC INDIVIDUAL BODY WEIGHT TABLE DATE: 11/29/04
ROUTE: DOSED FEED EISRPT12 TIME: 09:48:49
----------------------------------------------------------------------------------------------------------------------------------
SPECIES-STRAIN: RATS-F 344 SEX: MALE TRT: 625 PPM TRT#: 3 FIRST-DOSE: 01/20/00
----------------------------------------------------------------------------------------------------------------------------------
CAGE ANIMAL DAY ON DOSE
NO ID 117 145 173 201 229 257 285 313 341 369 397 425 453
----------------------------------------------------------------------------------------------------------------------------------
18 51 340.7 355.4 378.9 383.7 390.3 402.2 398.6 410.1 405.5 419.9 406.5 420.3 424.2
18 52 360.3 380.0 393.4 396.6 414.5 413.2 422.6 427.4 429.7 432.3 432.2 433.4 438.2
18 53 393.7 406.9 431.5 433.6 448.6 459.4 455.5 459.5 469.2 472.2 469.6 473.7 482.4
19 54 373.1 397.6 408.8 419.0 433.3 439.7 441.4 443.3 444.8 452.0 455.3 452.1 457.1
19 55 319.9 344.6 353.5 360.3 375.5 376.4 379.2 382.5 388.0 496.6 399.9 397.5 406.2
19 56 355.2 374.4 381.5 394.9 406.5 411.8 417.1 428.0 429.7 429.8 430.2 438.7 449.6
20 57 354.4 375.2 385.8 399.9 406.3 411.2 413.9 419.3 419.5 435.5 433.3 437.9 443.2
20 58 326.9 349.5 360.1 361.2 382.7 389.1 396.9 400.5 400.5 406.6 410.8 416.4 425.2
20 59 352.8 375.5 377.8 391.3 408.8 415.8 413.0 416.8 419.7 426.2 424.7 430.3 436.5
21 60 328.5 349.4 363.3 376.3 382.7 391.6 393.9 401.8 400.9 405.0 407.7 408.3 417.0
21 61 359.5 370.8 379.1 390.9 401.6 409.1 405.1 412.5 413.6 418.6 420.1 422.9 428.3
21 62 339.9 357.4 363.1 379.1 377.8 387.8 393.1 395.6 398.9 402.7 400.0 403.0 403.1
22 63 358.9 379.4 393.0 404.6 407.8 420.3 429.0 429.9 420.9 422.8 417.7 421.5 427.7
22 64 355.4 372.6 395.5 407.0 380.3 417.6 413.2 420.7 413.2 427.5 423.4 419.8 430.8
22 65 336.9 358.6 375.2 382.5 388.5 397.4 399.3 403.0 394.7 409.4 409.7 413.2 417.4
23 66 338.4 359.9 370.9 381.0 393.4 386.3 396.2 401.0 411.0 417.7 415.8 424.8 427.0
23 67 356.8 378.2 381.8 397.8 414.2 413.2 418.9 426.5 427.1 429.4 432.5 434.5 439.6
23 68 378.4 404.5 412.0 436.5 443.9 448.0 453.4 455.1 451.9 460.1 457.2 457.2 463.1
24 69 402.7 414.6 421.8 437.1 427.8 430.4 443.4 444.7 444.2 445.0 438.8 433.5 440.4
24 70 380.1 395.7 406.8 425.0 426.8 423.9 432.9 433.5 444.4 447.2 445.9 440.2 457.1
24 71 357.1 372.6 389.6 404.3 389.4 342.3 @
25 72 336.6 353.0 365.4 375.3 384.7 391.4 401.4 398.7 409.4 412.2 405.7 407.7 416.7
25 73 353.4 373.7 389.2 404.7 411.8 409.7 428.7 434.7 438.4 432.4 407.7 416.7 416.9
25 74 350.3 367.5 381.7 400.2 410.5 416.3 420.9 428.7 437.2 439.9 435.8 450.3 457.0
26 75 337.1 355.8 367.6 377.1 387.7 391.0 390.2 397.2 401.6 404.5 406.2 407.3 412.3
26 76 328.4 351.0 365.2 372.6 385.3 386.4 388.4 397.6 393.0 431.0 389.8 391.5 401.9
26 77 306.0 324.7 337.7 348.6 362.6 361.2 369.0 376.1 382.1 390.3 390.7 398.4 406.3
27 78 368.6 384.9 401.7 417.7 434.2 440.3 449.4 443.9 449.6 446.3 445.2 448.4 451.8
27 79 336.8 358.3 364.4 371.9 382.5 386.8 387.5 396.6 406.0 402.3 404.2 417.2 414.9
27 80 325.3 344.4 349.5 364.3 380.4 387.7 387.9 398.8 400.0 395.2 394.9 398.8 406.8
28 81 370.4 393.6 392.4 416.9 420.3 417.7 427.4 434.9 440.7 445.5 436.1 447.5 455.9
28 82 356.9 376.7 381.8 391.2 406.0 411.6 416.4 421.7 425.3 431.8 430.3 437.0 450.8
28 83 363.1 380.1 391.8 419.5 420.2 425.9 434.6 436.7 439.9 451.3 433.5 443.3 461.3
29 84 359.3 377.1 390.5 405.7 418.7 425.5 424.4 430.7 427.2 437.0 440.6 450.4 457.4
29 85 423.0 441.1 454.2 469.9 472.8 480.3 483.7 483.2 479.2 490.8 483.3 483.4 496.9
29 86 334.4 356.1 368.9 376.2 386.6 392.8 396.7 399.5 402.3 404.7 398.5 396.5 408.0
30 87 362.1 339.4 385.5 396.5 399.5 420.4 418.0 423.8 421.5 416.1 432.4 426.5 433.7
30 88 367.4 350.6 400.8 414.9 412.8 432.8 438.9 442.3 444.9 491.3 449.4 451.7 455.5
30 89 348.6 336.3 380.6 396.4 398.7 422.6 423.5 425.8 433.6 422.1 444.3 444.8 449.6
31 90 318.4 335.9 349.2 365.5 359.7 343.1 @
31 91 343.1 355.6 370.0 383.0 367.1 403.3 399.8 404.4 412.0 407.0 406.0 416.0 425.0
31 92 383.1 394.8 408.7 424.3 406.0 442.2 444.2 434.7 439.1 436.6 436.3 443.0 449.6
32 93 339.0 353.5 370.8 389.3 394.6 396.7 401.7 410.3 400.8 405.9 405.5 406.5 411.1
32 94 335.7 344.9 368.9 381.8 390.4 391.8 390.7 388.5 393.8 396.1 398.5 404.2 420.1
32 95 332.7 295.0 359.5 366.2 381.8 378.5 381.5 384.4 393.5 396.2 397.7 398.2 407.6
33 96 357.8 366.8 382.3 402.4 412.9 420.9 422.0 434.1 445.0 449.0 450.2 456.7 461.9
33 97 368.0 391.3 394.8 414.3 421.8 422.3 431.6 433.6 439.1 444.0 460.2 444.2 430.6 @
NTP EXP/TEST: 92013-05 4-METHYLIMIDAZOLE PAGE: 35
TEST TYPE: CHRONIC INDIVIDUAL BODY WEIGHT TABLE DATE: 11/29/04
ROUTE: DOSED FEED EISRPT12 TIME: 09:48:49
----------------------------------------------------------------------------------------------------------------------------------
SPECIES-STRAIN: RATS-F 344 SEX: MALE TRT: 625 PPM TRT#: 3 FIRST-DOSE: 01/20/00
----------------------------------------------------------------------------------------------------------------------------------
CAGE ANIMAL DAY ON DOSE
NO ID 117 145 173 201 229 257 285 313 341 369 397 425 453
----------------------------------------------------------------------------------------------------------------------------------
33 98 343.9 363.8 375.3 390.3 401.7 409.1 407.1 416.7 416.9 421.5 424.2 430.7 434.4
34 99 365.5 385.7 391.8 408.7 416.2 422.0 425.3 428.3 426.2 432.5 431.1 441.1 444.1
34 100 334.0 351.4 362.9 377.4 384.4 381.9 392.1 392.0 400.5 397.2 407.7 413.2 426.1
----- ----- ----- ----- ----- ----- ----- ----- ----- ----- ----- ----- -----
MEAN WT(G) 352.4 367.5 382.5 395.7 402.3 408.0 414.6 419.0 421.4 428.9 424.5 428.1 435.0
SD 22.1 24.8 21.6 23.5 22.6 26.2 23.3 22.0 21.9 25.3 22.0 21.4 21.7
NO. OBSER. 50 50 50 50 50 50 48 48 48 48 48 48 48
AVE. BODY WT
REL. TO CNTL 0.96 0.96 0.97 0.96 0.96 0.96 0.97 0.97 0.96 0.98 0.97 0.96 0.97
(TRT#: 1 )
BLANK MISSING DATA @ ANIMAL REMOVED FROM STUDY
() TRT# OF THE CONTROL GROUP USED IN CALCULATION * MULTIPLE OBSERVATIONS, LAST WEIGHT DISPLAYED
NTP EXP/TEST: 92013-05 4-METHYLIMIDAZOLE PAGE: 36
TEST TYPE: CHRONIC INDIVIDUAL BODY WEIGHT TABLE DATE: 11/29/04
ROUTE: DOSED FEED EISRPT12 TIME: 09:48:49
----------------------------------------------------------------------------------------------------------------------------------
SPECIES-STRAIN: RATS-F 344 SEX: MALE TRT: 625 PPM TRT#: 3 FIRST-DOSE: 01/20/00
----------------------------------------------------------------------------------------------------------------------------------
CAGE ANIMAL DAY ON DOSE
NO ID 481 509 537 565 593 621 649 677 705
----------------------------------------------------------------------------------------------------------------------------------
18 51 415.7 424.0 427.5 422.3 422.9 411.5 416.2 384.3 394.6
18 52 434.3 421.2 411.6 384.3 @
18 53 487.0 479.0 485.3 474.5 482.4 470.8 471.1 451.5 454.1
19 54 441.3 445.1 445.7 441.3 443.5 427.4 436.0 433.2 421.5
19 55 409.4 408.0 407.6 403.3 404.0 400.2 408.0 391.1 384.3
19 56 438.3 437.2 443.2 439.4 433.1 426.3 434.6 430.4 411.9
20 57 440.2 440.3 446.4 421.9 431.7 431.6 439.7 433.4 431.8
20 58 420.5 418.1 399.1 342.1 @
20 59 435.9 432.8 434.9 407.4 421.6 418.3 423.0 413.2 409.9
21 60 412.9 409.8 420.5 412.0 416.6 418.7 419.6 418.3 417.1
21 61 425.5 420.4 424.0 413.5 412.3 411.8 416.4 412.8 408.4
21 62 399.4 396.6 399.7 394.4 391.5 387.2 392.6 385.2 387.4
22 63 424.8 420.2 433.8 423.6 421.9 415.4 424.7 420.4 @
22 64 435.9 422.1 439.8 425.9 419.2 421.9 430.7 431.1 417.7
22 65 415.4 411.1 416.8 408.7 426.0 402.4 408.2 404.4 393.0
23 66 426.1 416.6 415.8 425.5 424.5 415.7 435.4 435.6 427.6
23 67 438.6 430.0 432.5 432.1 422.7 @
23 68 460.2 451.2 450.1 447.2 440.7 431.4 444.0 437.5 432.0
24 69 431.1 423.0 423.0 417.0 343.7 403.4 407.2 407.2 396.2
24 70 444.7 414.3 @
24 71
25 72 412.0 407.9 413.6 410.6 401.9 396.3 399.9 400.0 384.2
25 73 404.2 396.1 381.7 @
25 74 450.7 440.2 448.1 435.2 427.7 416.5 428.2 430.5 421.6
26 75 406.9 408.7 413.4 419.4 404.3 371.8 @
26 76 398.5 396.4 400.2 404.0 403.2 390.7 404.4 400.1 391.9
26 77 401.3 396.6 398.8 408.1 396.3 393.6 394.9 392.6 389.7
27 78 444.6 428.7 436.6 430.7 428.1 425.4 429.2 417.1 395.0
27 79 393.8 373.6 348.2 376.4 341.2 342.1 336.3 349.5 @
27 80 409.6 388.5 388.8 390.3 384.0 375.7 384.1 361.7 @
28 81 450.3 446.3 454.0 439.4 441.2 429.0 440.7 434.5 432.4
28 82 443.6 433.9 435.0 428.7 423.7 422.1 425.2 415.6 422.3
28 83 460.2 451.0 452.3 442.8 434.4 431.7 437.5 428.0 422.1
29 84 467.7 468.1 462.9 424.8 @
29 85 492.5 481.2 492.8 488.6 473.5 434.0 450.0 429.5 384.2 @
29 86 411.0 404.1 405.7 396.6 385.5 373.5 389.9 382.7 372.5
30 87 427.9 423.0 412.6 415.8 415.1 405.7 410.7 405.8 404.4
30 88 449.2 439.2 436.5 440.2 433.7 419.3 423.8 420.3 404.5
30 89 447.0 445.2 443.8 440.5 445.1 431.8 443.6 438.8 416.4
31 90
31 91 422.8 418.6 410.8 413.9 413.8 403.5 404.2 398.2 390.2
31 92 444.8 441.8 433.4 442.4 439.2 429.6 440.5 420.9 405.9
32 93 399.3 397.4 401.5 399.3 392.7 393.4 367.7 @
32 94 403.6 397.6 398.1 394.6 384.5 377.9 363.2 370.2 367.1
32 95 404.1 400.6 403.8 396.8 393.1 385.6 364.0 368.3 357.1
33 96 451.1 451.6 449.0 446.8 440.0 442.8 451.7 411.8 439.1
33 97
NTP EXP/TEST: 92013-05 4-METHYLIMIDAZOLE PAGE: 37
TEST TYPE: CHRONIC INDIVIDUAL BODY WEIGHT TABLE DATE: 11/29/04
ROUTE: DOSED FEED EISRPT12 TIME: 09:48:49
----------------------------------------------------------------------------------------------------------------------------------
SPECIES-STRAIN: RATS-F 344 SEX: MALE TRT: 625 PPM TRT#: 3 FIRST-DOSE: 01/20/00
----------------------------------------------------------------------------------------------------------------------------------
CAGE ANIMAL DAY ON DOSE
NO ID 481 509 537 565 593 621 649 677 705
----------------------------------------------------------------------------------------------------------------------------------
33 98 424.2 424.5 421.8 424.7 422.1 421.2 423.7 442.8 407.3
34 99 443.7 434.7 421.3 407.9 390.8 371.6 355.2 326.1 @
34 100 416.5 408.5 407.6 404.5 402.4 362.5 399.1 387.1 387.2
----- ----- ----- ----- ----- ----- ----- ----- -----
MEAN WT(G) 430.2 423.9 424.6 419.1 416.1 408.3 414.4 408.2 405.2
SD 22.9 23.0 26.2 25.0 27.5 25.1 29.0 27.6 21.5
NO. OBSER. 47 47 46 45 42 41 40 39 35
AVE. BODY WT
REL. TO CNTL 0.97 0.96 0.97 0.96 0.96 0.97 0.97 0.97 1.01
(TRT#: 1 )
BLANK MISSING DATA @ ANIMAL REMOVED FROM STUDY
() TRT# OF THE CONTROL GROUP USED IN CALCULATION * MULTIPLE OBSERVATIONS, LAST WEIGHT DISPLAYED
NTP EXP/TEST: 92013-05 4-METHYLIMIDAZOLE PAGE: 38
TEST TYPE: CHRONIC INDIVIDUAL BODY WEIGHT TABLE DATE: 11/29/04
ROUTE: DOSED FEED EISRPT12 TIME: 09:48:49
----------------------------------------------------------------------------------------------------------------------------------
SPECIES-STRAIN: RATS-F 344 SEX: MALE TRT: 1250 PPM TRT#: 5 FIRST-DOSE: 01/20/00
----------------------------------------------------------------------------------------------------------------------------------
CAGE ANIMAL DAY ON DOSE
NO ID 1 12 19 26 33 40 47 54 61 68 75 82 89
----------------------------------------------------------------------------------------------------------------------------------
35 101 121.3 163.4 190.0 218.1 235.8 248.5 263.4 276.3 284.1 288.8 288.1 291.7 292.9
35 102 125.4 168.0 203.1 234.5 254.6 269.5 282.2 299.5 309.7 316.7 318.0 326.4 326.6
35 103 113.4 153.8 182.2 215.5 237.7 257.1 272.1 288.6 301.0 298.8 297.1 303.9 306.3
36 104 121.7 162.3 188.6 213.2 228.4 239.2 252.6 265.5 271.1 279.8 279.4 287.0 287.2
36 105 139.3 182.4 213.0 240.7 256.9 269.0 278.5 287.9 289.6 292.8 300.7 307.7 308.7
36 106 120.2 161.4 192.2 221.9 242.0 257.5 270.6 285.1 290.4 293.3 293.6 300.9 300.9
37 107 141.0 186.8 214.8 242.7 263.0 281.3 291.9 305.7 307.5 312.9 312.1 322.0 325.7
37 108 116.3 160.8 167.4 219.3 239.2 259.2 273.4 286.1 290.4 293.9 297.3 312.1 316.1
37 109 136.5 181.2 209.0 237.9 256.8 271.3 281.0 290.0 292.0 294.3 294.3 303.7 303.8
38 110 103.2 146.1 180.2 211.5 226.8 242.9 256.1 269.0 274.6 281.2 287.8 297.8 297.0
38 111 110.6 161.3 192.1 220.3 235.6 248.6 260.4 276.5 280.2 291.8 290.1 299.5 297.7
38 112 124.9 168.0 197.7 224.7 243.4 260.3 274.8 288.7 298.2 304.0 309.7 318.9 315.5
39 113 127.4 173.9 208.5 237.3 252.1 267.1 277.4 296.6 305.9 316.8 314.3 324.8 326.9
39 114 135.7 183.6 209.3 234.3 248.7 263.0 270.8 288.7 299.9 306.9 308.2 315.8 312.9
39 115 116.7 148.3 170.1 188.7 200.8 212.2 218.4 228.4 232.6 237.2 238.3 247.3 251.2
40 116 128.0 172.7 198.0 221.3 236.8 247.1 259.2 274.6 285.5 295.5 302.6 304.3 303.6
40 117 109.3 148.9 176.5 203.5 213.6 229.5 245.5 261.2 273.3 287.5 297.7 303.7 298.7
40 118 137.4 176.3 204.1 229.9 244.3 258.5 270.7 287.5 296.2 303.7 304.0 304.2 297.2
41 119 131.5 172.7 200.7 222.9 242.0 253.3 264.9 278.5 285.0 294.4 294.2 298.5 298.0
41 120 118.8 158.6 185.7 213.3 230.9 244.6 254.4 272.3 281.4 287.8 296.5 300.5 305.2
41 121 127.6 164.7 189.5 211.3 227.5 241.0 251.4 266.5 276.6 287.0 287.8 294.2 293.6
42 122 109.1 151.0 181.6 212.5 230.0 245.8 257.3 276.4 286.9 299.9 303.2 316.2 318.5
42 123 137.8 181.5 205.6 233.3 243.5 257.5 267.7 283.6 289.0 294.3 291.9 302.8 301.5
42 124 118.6 161.5 188.5 216.7 232.7 246.6 257.7 275.0 286.8 295.7 292.0 297.7 296.5
43 125 115.5 155.9 184.1 211.2 225.5 242.9 249.3 259.8 263.0 265.5 270.9 277.1 280.9
43 126 112.2 157.5 181.6 207.0 221.2 233.1 246.5 262.1 268.9 273.8 273.6 284.0 284.7
43 127 111.6 155.4 188.0 214.9 231.8 248.2 260.3 269.8 276.4 280.3 280.9 291.2 290.9
44 128 125.2 170.5 198.0 225.7 238.4 253.8 263.5 279.8 289.5 298.2 301.1 310.0 309.4
44 129 136.0 179.6 204.4 232.2 248.6 264.8 279.3 294.5 304.5 304.7 304.7 311.6 310.0
44 130 130.6 177.5 209.1 241.9 256.9 273.3 289.6 306.9 320.1 329.4 330.1 341.1 342.2
45 131 128.8 169.0 197.4 223.9 240.9 259.1 274.4 291.5 303.2 312.8 311.0 316.6 319.7
45 132 130.7 171.6 197.0 221.9 237.8 251.7 265.0 280.7 287.2 295.0 292.7 303.9 305.3
45 133 107.9 141.6 167.9 190.1 206.5 219.4 229.7 240.6 247.5 259.3 260.4 267.8 273.0
46 134 135.3 180.8 204.5 233.1 246.3 262.9 274.4 293.0 304.6 309.7 312.0 319.8 318.6
46 135 111.7 153.0 185.4 215.1 230.3 245.3 257.9 279.9 286.3 294.5 297.0 305.7 301.2
46 136 106.5 148.8 179.7 211.3 232.3 254.5 268.5 289.3 298.3 309.5 309.8 317.3 315.4
47 137 128.2 173.7 204.9 230.2 247.8 262.0 271.2 286.2 290.4 294.2 299.4 311.0 314.9
47 138 127.1 164.0 194.6 223.5 239.6 255.4 270.5 288.0 293.7 297.9 296.7 304.8 305.0
47 139 121.6 157.5 189.1 217.7 233.2 250.7 261.5 277.1 283.9 288.5 288.6 298.4 301.0
48 140 123.5 161.6 187.1 215.7 231.0 244.2 261.3 275.1 284.3 288.2 293.3 297.9 256.7
48 141 116.9 160.5 191.5 223.8 241.6 258.0 274.1 293.4 302.0 305.8 305.4 310.1 306.8
48 142 138.7 181.5 209.6 238.5 248.8 266.0 276.8 295.1 304.1 307.5 310.4 314.6 306.0
49 143 113.2 158.7 192.6 222.7 238.7 251.9 266.5 280.0 289.2 298.0 298.4 306.5 301.8
49 144 101.3 145.0 178.6 208.1 226.7 243.8 258.7 278.2 289.2 295.5 295.7 306.3 305.1
49 145 128.3 170.2 199.8 226.3 240.6 254.7 267.0 285.0 294.8 303.5 302.9 312.5 312.1
50 146 127.2 168.4 193.8 223.3 237.4 253.5 266.4 281.5 294.1 301.4 300.2 268.9 298.4
50 147 116.4 157.5 186.1 214.4 226.5 239.6 253.3 270.4 280.3 290.5 290.8 301.8 299.0
NTP EXP/TEST: 92013-05 4-METHYLIMIDAZOLE PAGE: 39
TEST TYPE: CHRONIC INDIVIDUAL BODY WEIGHT TABLE DATE: 11/29/04
ROUTE: DOSED FEED EISRPT12 TIME: 09:48:49
----------------------------------------------------------------------------------------------------------------------------------
SPECIES-STRAIN: RATS-F 344 SEX: MALE TRT: 1250 PPM TRT#: 5 FIRST-DOSE: 01/20/00
----------------------------------------------------------------------------------------------------------------------------------
CAGE ANIMAL DAY ON DOSE
NO ID 1 12 19 26 33 40 47 54 61 68 75 82 89
----------------------------------------------------------------------------------------------------------------------------------
50 148 114.7 149.2 176.7 199.0 213.7 223.5 231.9 246.3 253.5 258.8 261.1 268.4 271.6
51 149 139.2 182.4 215.3 238.7 254.3 269.3 280.1 296.8 305.9 317.5 321.4 327.2 320.7
51 150 131.6 173.4 205.6 236.9 247.2 265.1 273.0 295.9 306.7 321.1 325.6 333.3 328.1
----- ----- ----- ----- ----- ----- ----- ----- ----- ----- ----- ----- -----
MEAN WT(G) 123.0 165.1 193.4 221.4 237.3 252.3 264.5 280.1 288.2 295.1 296.7 303.8 303.2
SD 10.6 11.8 12.3 12.5 12.9 13.8 14.3 15.4 16.2 16.6 16.4 17.3 17.0
NO. OBSER. 50 50 50 50 50 50 50 50 50 50 50 50 50
AVE. BODY WT
REL. TO CNTL 0.99 0.92 0.92 0.92 0.93 0.94 0.92 0.92 0.92 0.91 0.90 0.89 0.88
(TRT#: 1 )
BLANK MISSING DATA @ ANIMAL REMOVED FROM STUDY
() TRT# OF THE CONTROL GROUP USED IN CALCULATION * MULTIPLE OBSERVATIONS, LAST WEIGHT DISPLAYED
NTP EXP/TEST: 92013-05 4-METHYLIMIDAZOLE PAGE: 40
TEST TYPE: CHRONIC INDIVIDUAL BODY WEIGHT TABLE DATE: 11/29/04
ROUTE: DOSED FEED EISRPT12 TIME: 09:48:49
----------------------------------------------------------------------------------------------------------------------------------
SPECIES-STRAIN: RATS-F 344 SEX: MALE TRT: 1250 PPM TRT#: 5 FIRST-DOSE: 01/20/00
----------------------------------------------------------------------------------------------------------------------------------
CAGE ANIMAL DAY ON DOSE
NO ID 117 145 173 201 229 257 285 313 341 369 397 425 453
----------------------------------------------------------------------------------------------------------------------------------
35 101 312.8 326.3 342.3 332.3 347.1 370.6 374.9 372.7 379.9 382.8 381.1 388.1 393.5
35 102 334.4 346.7 353.0 364.1 361.6 382.9 380.2 383.9 386.8 388.4 384.2 391.0 401.5
35 103 328.4 337.6 354.3 367.5 365.3 381.3 383.4 387.5 387.4 397.1 391.6 397.7 403.3
36 104 306.5 323.4 331.8 349.5 351.2 356.0 356.4 360.1 369.6 366.9 366.2 377.1 379.3
36 105 334.0 355.4 363.8 379.7 386.2 394.8 394.6 400.2 403.2 406.9 407.2 413.6 414.7
36 106 318.7 335.2 343.6 358.3 369.0 375.3 372.2 376.4 384.0 386.3 380.8 390.3 388.2
37 107 347.0 360.0 373.9 383.4 396.1 400.7 408.7 413.4 420.9 421.3 413.8 425.2 432.9
37 108 333.3 354.2 365.7 375.2 389.3 386.0 382.0 394.6 395.2 395.2 391.7 398.6 407.2
37 109 323.7 344.0 348.4 359.4 370.1 370.8 371.2 374.4 381.6 379.3 376.5 382.1 390.0
38 110 314.8 332.3 345.9 354.4 361.8 372.0 367.9 379.1 388.7 384.3 391.0 392.8 397.8
38 111 311.2 326.6 335.6 345.7 323.3 362.9 358.7 360.6 372.1 369.8 371.2 368.6 370.7
38 112 335.3 356.7 368.0 374.8 380.1 396.8 398.7 400.3 409.2 408.9 409.2 409.1 415.1
39 113 338.4 354.7 365.2 366.4 379.2 383.3 382.5 396.0 404.6 400.5 405.7 406.6 409.8
39 114 324.0 336.0 349.3 360.5 378.8 387.8 383.2 392.0 399.7 400.3 403.7 413.7 413.2
39 115 278.1 301.3 314.5 326.8 339.2 344.9 345.9 352.0 358.7 358.4 360.7 369.7 374.5
40 116 324.4 339.5 342.1 354.6 360.6 369.3 377.0 379.0 385.8 382.9 381.5 389.3 395.4
40 117 332.2 344.2 346.1 361.7 368.6 374.3 385.6 382.1 388.7 389.2 388.9 401.0 405.4
40 118 330.4 346.9 351.9 366.7 370.9 368.3 372.4 372.5 378.3 384.4 379.7 384.3 386.9
41 119 314.8 333.4 341.5 349.0 357.1 361.9 365.6 368.8 375.6 371.0 373.6 379.3 353.1
41 120 319.5 335.0 350.2 363.8 374.3 378.6 382.2 383.2 397.7 399.2 399.2 400.5 371.9
41 121 305.8 320.6 325.9 339.7 344.7 349.0 358.6 359.0 364.7 361.9 364.3 369.4 350.4
42 122 332.4 346.3 360.7 374.3 383.0 390.4 393.0 391.2 401.7 391.1 388.0 398.5 397.2
42 123 315.8 328.1 342.3 353.3 358.7 368.4 370.7 370.9 380.9 378.9 378.4 382.9 326.1
42 124 314.2 326.0 331.6 344.2 353.3 356.5 364.9 362.9 364.9 364.4 367.0 377.3 369.7
43 125 298.2 311.4 323.1 341.0 346.5 355.3 356.3 361.9 366.2 369.7 365.0 372.0 319.6
43 126 304.5 331.1 344.7 355.0 358.6 369.1 361.5 361.5 369.4 364.3 366.5 377.1 374.9
43 127 306.2 323.9 330.8 347.4 351.6 358.1 358.7 360.2 362.7 365.8 367.2 369.4 373.1
44 128 326.2 342.2 355.0 372.3 373.7 384.7 383.4 384.3 392.1 393.3 393.7 403.2 396.5
44 129 333.0 342.3 357.0 376.8 381.3 386.7 391.6 391.9 397.8 398.9 405.6 408.1 405.1
44 130 355.2 378.4 393.9 413.4 422.8 435.4 432.5 429.2 441.3 440.2 449.5 455.1 446.0
45 131 341.4 359.4 376.3 393.7 394.7 403.9 403.7 411.6 417.0 421.8 430.0 431.8 437.4
45 132 331.7 348.2 357.6 372.9 377.5 389.4 364.4 396.8 397.7 394.7 400.7 406.6 410.1
45 133 293.6 311.6 320.2 335.4 339.0 351.3 331.9 356.1 361.4 364.8 369.6 373.4 381.1
46 134 327.4 354.2 358.2 373.9 374.9 392.3 396.1 397.8 401.7 398.3 389.4 404.4 411.3
46 135 323.7 341.1 349.0 360.7 367.0 378.9 377.8 374.1 378.1 376.5 377.7 382.7 444.1
46 136 340.0 366.3 374.1 390.2 399.8 411.4 419.9 420.4 422.0 426.2 432.2 433.9 388.7
47 137 329.4 345.6 359.2 373.0 378.2 385.7 385.2 388.7 385.0 377.9 391.0 386.1 379.7
47 138 331.1 346.1 361.7 377.7 384.0 392.9 392.6 396.9 395.2 333.0 398.1 408.0 410.8
47 139 318.6 337.1 350.1 365.1 375.3 384.1 388.4 388.2 384.4 378.4 392.7 398.1 404.4
48 140 310.8 336.6 349.5 356.5 364.1 374.0 372.9 378.8 306.6 350.2 380.8 386.0 397.9
48 141 316.3 342.5 358.6 372.7 384.8 401.3 403.3 399.6 307.1 371.5 408.5 417.5 425.9
48 142 324.2 350.8 366.8 373.9 385.4 396.7 392.7 395.6 364.5 382.5 402.9 406.8 412.6
49 143 315.0 336.3 351.5 362.4 369.1 378.7 377.7 385.4 393.6 389.9 394.8 403.1 408.8
49 144 319.5 340.1 353.0 363.9 378.9 388.6 388.2 389.9 399.7 389.6 402.0 404.0 411.7
49 145 314.7 348.5 361.8 375.2 383.7 395.1 389.5 399.0 404.2 391.8 404.9 407.1 408.2
50 146 316.5 335.4 345.1 354.8 365.4 372.3 374.1 380.3 383.5 389.5 386.1 390.9 400.1
50 147 322.6 340.8 351.9 362.4 362.7 374.5 376.8 376.1 376.1 383.5 382.6 384.2 390.8
NTP EXP/TEST: 92013-05 4-METHYLIMIDAZOLE PAGE: 41
TEST TYPE: CHRONIC INDIVIDUAL BODY WEIGHT TABLE DATE: 11/29/04
ROUTE: DOSED FEED EISRPT12 TIME: 09:48:49
----------------------------------------------------------------------------------------------------------------------------------
SPECIES-STRAIN: RATS-F 344 SEX: MALE TRT: 1250 PPM TRT#: 5 FIRST-DOSE: 01/20/00
----------------------------------------------------------------------------------------------------------------------------------
CAGE ANIMAL DAY ON DOSE
NO ID 117 145 173 201 229 257 285 313 341 369 397 425 453
----------------------------------------------------------------------------------------------------------------------------------
50 148 291.6 313.1 320.8 332.9 333.1 343.6 346.2 349.4 359.6 359.4 361.8 359.7 370.2
51 149 338.7 353.4 364.0 372.1 382.6 386.9 394.2 402.1 401.2 405.4 399.9 405.1 407.4
51 150 347.6 366.7 365.8 377.0 386.7 394.5 394.3 403.7 403.3 400.6 398.9 406.3 414.1
----- ----- ----- ----- ----- ----- ----- ----- ----- ----- ----- ----- -----
MEAN WT(G) 322.2 340.3 350.9 363.2 369.8 379.4 379.7 383.8 385.0 385.7 390.1 395.7 395.6
SD 15.0 15.1 15.8 16.6 18.4 17.9 18.7 17.9 24.0 20.0 18.8 18.8 25.6
NO. OBSER. 50 50 50 50 50 50 50 50 50 50 50 50 50
AVE. BODY WT
REL. TO CNTL 0.88 0.89 0.89 0.88 0.89 0.89 0.89 0.89 0.88 0.88 0.89 0.89 0.88
(TRT#: 1 )
BLANK MISSING DATA @ ANIMAL REMOVED FROM STUDY
() TRT# OF THE CONTROL GROUP USED IN CALCULATION * MULTIPLE OBSERVATIONS, LAST WEIGHT DISPLAYED
NTP EXP/TEST: 92013-05 4-METHYLIMIDAZOLE PAGE: 42
TEST TYPE: CHRONIC INDIVIDUAL BODY WEIGHT TABLE DATE: 11/29/04
ROUTE: DOSED FEED EISRPT12 TIME: 09:48:49
----------------------------------------------------------------------------------------------------------------------------------
SPECIES-STRAIN: RATS-F 344 SEX: MALE TRT: 1250 PPM TRT#: 5 FIRST-DOSE: 01/20/00
----------------------------------------------------------------------------------------------------------------------------------
CAGE ANIMAL DAY ON DOSE
NO ID 481 509 537 565 593 621 649 677 705
----------------------------------------------------------------------------------------------------------------------------------
35 101 392.4 390.2 394.6 379.6 361.8 389.9 385.2 388.2 386.6
35 102 396.8 389.5 393.6 382.9 380.8 390.3 389.4 389.6 383.8
35 103 405.3 398.6 400.0 400.2 389.6 393.1 389.4 363.5 @
36 104 381.3 374.5 381.2 307.8 387.9 383.6 382.1 374.1 376.4
36 105 417.2 403.8 408.0 357.4 401.4 372.2 @
36 106 387.6 372.2 381.3 266.9 367.8 372.1 368.3 364.1 360.6
37 107 429.4 421.1 425.7 426.2 414.4 405.0 407.4 402.7 399.0
37 108 406.3 403.2 404.9 412.1 412.4 404.8 404.3 412.0 414.5
37 109 390.4 382.1 386.0 388.8 322.4 @
38 110 387.2 372.4 342.3 @
38 111 366.2 363.1 361.1 301.1 355.1 345.9 351.3 346.6 330.6
38 112 416.6 414.3 415.7 403.5 411.9 397.8 398.0 398.8 389.5
39 113 497.9 @
39 114 414.0 404.3 407.4 388.3 337.5 @
39 115 380.9 371.3 375.0 364.1 366.4 338.5 @
40 116 397.0 382.5 392.3 382.3 373.7 380.4 377.4 377.2 349.5 @
40 117 410.8 400.7 411.9 401.5 409.7 412.1 414.7 413.1 417.8
40 118 390.2 380.9 391.9 378.3 387.2 384.4 383.9 386.1 385.3
41 119 379.7 381.6 380.4 380.3 381.0 371.3 375.2 376.1 367.5
41 120 404.0 404.2 403.7 400.8 404.1 400.5 403.9 408.7 400.8
41 121 365.4 370.1 371.0 369.9 374.9 371.9 366.0 373.5 365.5
42 122 402.6 406.2 406.1 397.2 385.7 369.0 283.6 @
42 123 392.0 392.0 398.9 393.1 392.5 384.9 387.7 387.9 376.2
42 124 379.5 375.3 367.6 357.3 367.3 362.6 373.5 371.1 339.7 @
43 125 370.5 370.1 370.0 372.3 373.7 365.8 364.1 356.5 331.3
43 126 375.0 374.0 367.6 363.5 356.9 326.0 275.7 @
43 127 377.5 369.8 372.5 373.3 376.3 383.2 403.1 443.9 @
44 128 404.1 406.1 409.3 398.5 396.3 398.1 396.4 394.0 391.4
44 129 409.3 407.8 411.1 404.8 409.6 408.3 407.1 406.8 400.7
44 130 453.2 437.1 443.3 435.3 436.5 425.4 412.4 404.8 399.6
45 131 443.1 433.4 436.7 433.4 432.5 430.7 432.7 428.9 424.2
45 132 410.1 412.1 404.8 406.5 396.8 390.9 391.7 388.9 381.1
45 133 387.9 379.3 381.2 379.1 378.3 377.2 @
46 134 413.8 408.2 406.1 396.8 395.4 376.1 370.6 366.1 328.4 @
46 135 384.6 382.9 379.7 375.6 376.4 374.1 374.8 375.4 352.7
46 136 448.1 445.0 436.0 424.4 432.9 430.5 414.0 417.0 403.0
47 137 380.1 377.5 375.7 371.6 368.5 372.7 367.2 373.0 362.4
47 138 412.1 408.3 405.4 406.6 402.3 398.7 390.5 401.0 385.9
47 139 407.5 404.0 406.1 402.4 401.8 403.2 395.4 396.6 394.1
48 140 400.1 398.9 395.4 394.4 396.7 387.7 392.5 395.0 391.6
48 141 420.6 413.2 412.2 404.7 407.9 401.8 399.0 404.4 403.3
48 142 412.5 407.0 403.5 399.8 393.0 389.5 383.5 382.7 372.2
49 143 401.5 405.3 395.7 399.8 390.7 396.1 389.8 383.2 360.8
49 144 408.2 402.7 409.3 410.0 402.1 404.6 395.7 394.1 389.5
49 145 384.5 @
50 146 406.9 398.9 401.3 409.3 405.3 394.7 395.5 289.3 @
50 147 395.3 394.4 395.2 399.2 389.4 383.6 379.3 288.5 371.9
NTP EXP/TEST: 92013-05 4-METHYLIMIDAZOLE PAGE: 43
TEST TYPE: CHRONIC INDIVIDUAL BODY WEIGHT TABLE DATE: 11/29/04
ROUTE: DOSED FEED EISRPT12 TIME: 09:48:49
----------------------------------------------------------------------------------------------------------------------------------
SPECIES-STRAIN: RATS-F 344 SEX: MALE TRT: 1250 PPM TRT#: 5 FIRST-DOSE: 01/20/00
----------------------------------------------------------------------------------------------------------------------------------
CAGE ANIMAL DAY ON DOSE
NO ID 481 509 537 565 593 621 649 677 705
----------------------------------------------------------------------------------------------------------------------------------
50 148 369.7 369.2 371.2 373.2 370.4 366.7 363.6 258.2 343.1
51 149 415.3 413.9 404.0 401.4 393.1 388.4 367.6 386.4 380.7
51 150 412.5 404.3 @
----- ----- ----- ----- ----- ----- ----- ----- -----
MEAN WT(G) 401.9 395.4 395.6 386.4 388.4 386.5 383.0 381.2 378.1
SD 24.1 19.2 20.5 31.7 23.0 21.4 29.1 36.0 24.8
NO. OBSER. 50 48 47 46 46 44 41 39 36
AVE. BODY WT
REL. TO CNTL 0.90 0.89 0.90 0.88 0.90 0.92 0.90 0.90 0.94
(TRT#: 1 )
BLANK MISSING DATA @ ANIMAL REMOVED FROM STUDY
() TRT# OF THE CONTROL GROUP USED IN CALCULATION * MULTIPLE OBSERVATIONS, LAST WEIGHT DISPLAYED
NTP EXP/TEST: 92013-05 4-METHYLIMIDAZOLE PAGE: 44
TEST TYPE: CHRONIC INDIVIDUAL BODY WEIGHT TABLE DATE: 11/29/04
ROUTE: DOSED FEED EISRPT12 TIME: 09:48:49
----------------------------------------------------------------------------------------------------------------------------------
SPECIES-STRAIN: RATS-F 344 SEX: MALE TRT: 2500 PPM TRT#: 7 FIRST-DOSE: 01/20/00
----------------------------------------------------------------------------------------------------------------------------------
CAGE ANIMAL DAY ON DOSE
NO ID 1 12 19 26 33 40 47 54 61 68 75 82 89
----------------------------------------------------------------------------------------------------------------------------------
52 151 107.2 21.9 170.7 203.3 219.7 238.4 251.6 269.0 279.4 289.4 286.3 290.9 300.0
52 152 99.6 133.5 157.2 181.2 198.9 212.3 225.5 241.8 249.7 261.2 264.0 267.6 263.6
52 153 126.4 162.0 190.3 219.0 242.2 258.5 276.9 286.4 294.4 306.4 309.3 312.8 317.1
53 154 128.7 162.0 188.5 213.7 228.6 246.0 261.6 276.1 288.6 294.8 296.1 308.3 309.2
53 155 99.8 129.2 153.6 176.2 193.1 208.1 214.7 227.9 234.0 242.3 242.6 249.7 251.4
53 156 128.0 160.9 189.1 215.6 231.6 246.8 260.3 275.1 282.5 291.0 291.4 295.8 297.6
54 157 122.4 148.0 180.4 208.3 226.8 245.8 260.6 274.6 280.2 293.1 298.9 304.1 304.2
54 158 116.2 148.7 177.2 201.6 220.1 240.2 250.2 267.1 274.0 282.4 286.9 287.8 289.8
54 159 109.1 135.8 163.1 190.8 205.0 225.7 236.4 250.3 259.5 263.1 262.9 267.3 265.2
55 160 115.0 147.2 171.6 201.8 222.1 234.4 251.1 265.7 277.9 285.7 291.8 297.9 294.0
55 161 109.0 133.8 159.1 187.0 208.6 221.3 226.6 233.6 243.0 247.7 250.7 258.4 257.8
55 162 136.6 168.6 191.7 220.4 235.4 250.4 262.1 274.9 280.7 287.6 286.5 287.8 288.7
56 163 123.4 150.8 178.2 203.8 224.5 243.7 257.0 273.3 278.9 289.4 291.3 292.1 289.1
56 164 133.7 168.0 196.4 219.2 233.9 249.0 262.3 274.3 282.0 287.6 288.2 289.8 271.2
56 165 121.5 147.1 169.8 193.7 215.7 233.8 248.7 263.6 275.7 285.7 290.3 299.7 295.9
57 166 137.0 164.6 187.5 212.3 229.8 246.6 256.2 269.5 279.1 289.6 294.6 297.8 291.9
57 167 113.4 143.3 168.6 199.2 215.7 234.2 246.6 259.3 267.0 274.6 273.1 276.3 273.8
57 168 112.9 145.8 173.9 199.0 215.9 233.5 247.8 260.2 269.3 282.6 282.0 285.4 281.7
58 169 135.2 162.7 191.9 215.0 230.3 243.2 251.8 261.5 271.0 279.9 280.4 285.1 285.0
58 170 130.7 162.4 187.6 207.9 225.1 237.7 245.8 257.3 265.1 275.6 276.6 283.9 287.2
58 171 129.1 161.4 190.1 212.9 230.8 244.7 251.6 261.9 268.4 276.0 278.8 282.7 280.2
59 172 135.2 164.4 196.5 217.1 236.0 249.6 261.8 273.2 280.3 291.0 292.8 303.1 300.8
59 173 132.4 156.9 183.0 211.0 227.7 242.0 252.8 264.1 272.5 279.2 281.5 289.2 292.6
59 174 132.9 160.4 186.8 210.4 229.0 247.5 254.0 266.5 272.6 276.7 278.2 285.6 281.3
60 175 115.4 141.9 169.2 192.7 206.6 218.1 227.6 241.4 250.9 256.7 265.6 269.8 267.9
60 176 119.0 145.5 175.7 194.5 213.0 233.4 243.4 250.2 256.2 259.4 263.2 262.1 265.4
60 177 118.2 147.2 174.9 197.9 216.1 235.2 243.6 253.0 254.1 254.6 257.5 261.4 263.1
61 178 140.5 169.9 199.8 227.8 243.4 258.5 268.1 276.7 287.2 289.6 294.3 296.1 297.4
61 179 131.4 154.8 185.6 210.1 227.8 244.3 258.3 268.9 281.3 288.9 292.6 299.1 300.2
61 180 132.1 158.1 188.2 215.9 237.0 251.3 262.5 270.6 277.9 276.2 278.2 282.1 281.7
62 181 114.3 135.6 158.1 180.7 195.1 211.5 220.9 228.1 237.7 243.1 246.8 248.7 249.4
62 182 136.0 165.5 195.0 219.8 236.6 254.8 264.3 274.4 284.0 294.5 298.6 306.1 311.1
62 183 116.9 146.7 173.6 197.2 215.2 231.9 243.6 252.8 262.8 270.3 272.9 281.9 284.2
63 184 127.2 155.0 183.1 210.2 229.9 246.2 258.9 267.7 273.4 280.2 277.9 281.4 279.5
63 185 130.9 157.3 183.9 206.2 224.7 239.4 248.1 257.4 264.2 269.6 273.7 276.9 276.3
63 186 107.4 138.4 168.9 194.7 216.5 232.4 249.3 257.7 271.0 281.9 284.4 293.5 293.4
64 187 111.4 138.8 156.8 183.9 201.8 223.1 235.9 247.2 254.5 263.6 270.9 278.0 273.6
64 188 128.5 158.1 183.8 209.0 227.4 240.0 252.4 265.6 273.2 284.9 282.6 286.5 280.8
64 189 137.2 161.9 190.9 213.6 228.8 242.9 255.8 265.8 272.5 282.2 284.9 291.1 286.0
65 190 112.9 139.0 168.5 193.1 215.8 228.7 241.1 253.6 264.2 273.3 278.6 285.5 286.4
65 191 120.6 145.1 173.8 196.8 214.8 227.4 237.9 252.6 259.2 263.5 263.2 266.2 265.5
65 192 136.9 161.7 183.0 208.4 227.4 242.0 254.4 269.8 275.2 280.1 284.4 290.1 286.6
66 193 117.6 146.0 175.5 199.7 215.9 235.6 248.5 260.0 271.3 280.8 284.0 290.6 288.0
66 194 128.4 156.1 185.4 207.6 224.0 238.5 250.0 263.0 271.5 278.6 279.9 287.7 286.4
66 195 145.4 170.6 196.8 219.3 234.3 251.1 265.1 275.8 281.3 292.9 292.2 292.5 290.2
67 196 122.4 154.1 182.7 204.7 221.0 238.6 250.5 261.2 268.5 272.5 275.7 278.6 277.0
67 197 132.3 165.3 191.8 215.1 230.7 245.1 257.5 266.7 274.4 281.3 284.5 289.3 289.9
NTP EXP/TEST: 92013-05 4-METHYLIMIDAZOLE PAGE: 45
TEST TYPE: CHRONIC INDIVIDUAL BODY WEIGHT TABLE DATE: 11/29/04
ROUTE: DOSED FEED EISRPT12 TIME: 09:48:49
----------------------------------------------------------------------------------------------------------------------------------
SPECIES-STRAIN: RATS-F 344 SEX: MALE TRT: 2500 PPM TRT#: 7 FIRST-DOSE: 01/20/00
----------------------------------------------------------------------------------------------------------------------------------
CAGE ANIMAL DAY ON DOSE
NO ID 1 12 19 26 33 40 47 54 61 68 75 82 89
----------------------------------------------------------------------------------------------------------------------------------
67 198 135.8 159.6 186.2 208.5 223.1 237.6 250.0 260.6 263.9 269.0 269.7 273.2 266.6
68 199 121.8 149.5 180.1 205.1 224.6 241.7 253.6 262.7 273.6 279.8 281.8 284.2 282.1
68 200 135.0 165.8 191.9 219.4 236.8 251.7 265.4 272.1 280.1 289.2 284.0 286.2 283.4
----- ----- ----- ----- ----- ----- ----- ----- ----- ----- ----- ----- -----
MEAN WT(G) 124.2 150.5 180.1 205.0 222.7 238.7 250.4 262.1 270.2 277.8 279.9 284.8 283.6
SD 11.0 21.5 11.8 11.7 11.6 11.5 12.4 12.5 12.7 13.8 13.6 14.1 14.7
NO. OBSER. 50 50 50 50 50 50 50 50 50 50 50 50 50
AVE. BODY WT
REL. TO CNTL 1.00 0.84 0.86 0.85 0.87 0.88 0.88 0.86 0.86 0.86 0.85 0.83 0.82
(TRT#: 1 )
BLANK MISSING DATA @ ANIMAL REMOVED FROM STUDY
() TRT# OF THE CONTROL GROUP USED IN CALCULATION * MULTIPLE OBSERVATIONS, LAST WEIGHT DISPLAYED
NTP EXP/TEST: 92013-05 4-METHYLIMIDAZOLE PAGE: 46
TEST TYPE: CHRONIC INDIVIDUAL BODY WEIGHT TABLE DATE: 11/29/04
ROUTE: DOSED FEED EISRPT12 TIME: 09:48:49
----------------------------------------------------------------------------------------------------------------------------------
SPECIES-STRAIN: RATS-F 344 SEX: MALE TRT: 2500 PPM TRT#: 7 FIRST-DOSE: 01/20/00
----------------------------------------------------------------------------------------------------------------------------------
CAGE ANIMAL DAY ON DOSE
NO ID 117 145 173 201 229 257 285 313 341 369 397 425 453
----------------------------------------------------------------------------------------------------------------------------------
52 151 311.7 329.4 336.5 350.7 356.2 358.3 369.6 366.3 365.8 371.2 366.7 366.7 372.3
52 152 281.9 296.9 306.2 325.8 329.0 335.2 345.4 346.1 351.9 357.6 356.5 357.5 363.0
52 153 329.8 349.6 359.8 373.3 381.1 383.7 388.2 390.8 389.7 399.8 402.2 399.9 404.3
53 154 270.6 336.0 344.6 365.6 361.6 376.6 380.1 377.1 384.0 375.4 368.0 378.7 383.6
53 155 230.6 283.2 294.8 312.6 312.4 321.0 325.6 324.8 328.4 330.8 327.0 334.8 345.0
53 156 284.3 327.0 337.2 350.9 358.7 365.6 370.1 369.4 372.2 376.1 @
54 157 322.5 336.3 352.8 366.6 364.4 346.9 379.3 372.2 382.5 382.2 380.2 391.6 395.9
54 158 292.5 326.3 338.2 345.7 351.4 314.3 362.4 360.5 365.0 364.2 360.3 368.8 372.7
54 159 280.2 296.8 309.0 315.3 325.5 288.4 344.3 340.3 349.0 353.7 347.4 359.9 364.5
55 160 289.2 309.8 323.8 333.0 337.0 341.3 342.3 349.0 352.7 355.4 355.9 366.7 368.8
55 161 263.7 291.2 297.5 306.3 313.0 320.9 316.7 323.8 329.4 334.1 330.0 336.9 340.6
55 162 271.7 304.5 316.2 327.1 332.2 336.7 343.6 353.1 357.2 357.3 356.2 365.7 379.0
56 163 302.1 315.9 330.8 347.9 360.6 358.6 359.7 361.5 363.3 367.9 371.6 375.2 378.7
56 164 303.6 321.0 329.4 345.9 351.7 353.8 357.2 363.0 364.6 364.7 370.6 369.0 371.7
56 165 300.8 309.1 325.6 345.3 349.2 353.9 358.1 359.2 363.5 358.2 365.5 367.0 372.0
57 166 278.3 331.5 328.7 342.7 350.4 350.9 360.3 360.0 362.4 366.7 368.6 369.5 369.5
57 167 287.1 314.7 311.8 333.2 340.6 333.7 338.8 335.8 332.8 339.7 @
57 168 290.3 316.9 327.0 348.4 352.3 361.3 373.7 372.0 372.6 383.7 381.9 388.7 385.3
58 169 294.6 312.0 328.2 341.8 345.8 347.3 347.7 358.2 361.9 359.2 361.1 360.5 364.6
58 170 290.0 305.7 315.3 323.0 330.9 338.2 345.2 352.5 355.4 357.6 355.9 350.4 360.5
58 171 290.7 305.0 314.2 332.0 339.9 344.3 354.9 357.5 360.0 360.4 350.0 362.9 364.2
59 172 319.6 331.8 344.0 357.9 361.1 371.8 369.1 381.9 387.1 390.0 385.2 392.7 397.0
59 173 306.9 319.5 332.2 351.8 353.2 364.4 363.4 366.0 369.2 367.9 367.0 378.3 384.1
59 174 306.9 315.4 326.7 348.2 351.2 358.4 327.5 359.4 365.2 367.8 368.2 368.2 368.9
60 175 281.3 295.8 311.3 327.9 332.8 338.6 337.0 342.0 347.4 349.7 349.1 359.9 347.4
60 176 290.8 306.4 319.7 334.3 337.9 341.4 338.8 344.0 354.3 353.1 358.6 364.8 361.6
60 177 290.9 302.0 309.3 328.1 325.0 333.5 327.8 336.0 340.9 340.6 341.0 349.5 347.0
61 178 299.0 321.2 333.7 343.2 342.0 360.7 356.9 363.9 371.8 374.9 370.1 377.4 372.9
61 179 311.4 323.3 336.0 341.1 342.3 355.3 356.4 362.5 366.2 366.6 370.3 377.5 374.1
61 180 307.8 317.4 330.5 344.6 333.4 347.5 344.4 354.8 357.5 364.9 360.9 364.7 367.2
62 181 271.0 286.4 295.8 304.5 308.1 314.8 318.6 325.8 330.9 330.0 339.1 346.0 345.5
62 182 312.6 335.8 343.8 322.2 355.8 363.9 371.7 374.8 380.9 382.1 394.0 390.3 390.3
62 183 287.7 313.9 322.0 328.1 328.3 330.2 325.8 328.3 333.6 328.9 337.7 340.1 340.0
63 184 293.4 309.1 322.7 337.3 346.1 338.4 347.3 357.0 360.3 361.4 366.9 373.4 367.2
63 185 294.8 306.1 305.9 321.0 330.2 325.6 332.5 331.1 333.5 337.3 337.1 335.1 332.7
63 186 306.9 324.7 333.0 344.9 353.1 352.0 360.1 364.0 364.2 367.1 374.4 383.7 381.9
64 187 281.9 302.9 319.9 325.7 331.8 336.1 341.9 349.0 354.0 355.2 354.5 361.1 363.6
64 188 279.3 306.8 322.0 333.1 332.5 337.3 344.4 347.8 355.8 350.0 355.9 356.2 362.4
64 189 290.3 309.1 328.1 330.6 336.6 342.8 348.7 354.3 354.1 354.2 346.9 350.4 354.8
65 190 300.0 309.8 324.7 339.7 346.0 345.6 355.1 358.3 364.7 365.1 366.6 365.7 372.9
65 191 278.8 300.3 307.0 312.3 311.3 317.7 325.2 329.2 327.3 330.2 329.5 330.9 336.4
65 192 294.6 311.6 328.3 334.4 337.7 335.2 345.5 346.2 355.9 363.1 363.7 363.8 369.1
66 193 297.1 301.1 314.3 330.2 330.0 337.1 343.9 351.0 342.2 351.8 348.0 351.2 357.6
66 194 300.2 312.6 323.4 338.7 336.3 342.4 344.3 344.6 349.9 355.1 350.8 361.0 359.6
66 195 284.2 299.9 312.8 332.4 337.4 342.5 348.8 351.3 351.9 354.1 351.0 363.8 366.1
67 196 299.3 318.4 314.4 331.4 335.2 338.0 344.9 347.7 352.7 348.3 353.2 361.3 367.0
67 197 305.4 318.8 316.4 327.3 330.5 329.9 341.6 341.1 346.9 344.9 354.3 362.8 365.4
NTP EXP/TEST: 92013-05 4-METHYLIMIDAZOLE PAGE: 47
TEST TYPE: CHRONIC INDIVIDUAL BODY WEIGHT TABLE DATE: 11/29/04
ROUTE: DOSED FEED EISRPT12 TIME: 09:48:49
----------------------------------------------------------------------------------------------------------------------------------
SPECIES-STRAIN: RATS-F 344 SEX: MALE TRT: 2500 PPM TRT#: 7 FIRST-DOSE: 01/20/00
----------------------------------------------------------------------------------------------------------------------------------
CAGE ANIMAL DAY ON DOSE
NO ID 117 145 173 201 229 257 285 313 341 369 397 425 453
----------------------------------------------------------------------------------------------------------------------------------
67 198 282.6 301.6 304.7 322.6 324.8 328.2 335.3 341.0 344.2 340.2 340.5 346.3 349.6
68 199 289.1 308.9 320.5 333.3 334.5 340.0 348.3 351.5 359.8 357.2 360.6 363.2 366.0
68 200 262.1 317.0 326.7 335.1 327.8 336.8 341.5 348.6 353.3 355.1 354.3 360.3 362.4
----- ----- ----- ----- ----- ----- ----- ----- ----- ----- ----- ----- -----
MEAN WT(G) 291.8 312.9 323.1 335.9 339.9 342.7 349.0 352.9 356.8 358.5 358.9 364.0 366.4
SD 16.9 13.5 13.9 14.5 14.9 17.3 16.1 15.0 15.2 15.7 15.8 15.5 15.5
NO. OBSER. 50 50 50 50 50 50 50 50 50 50 48 48 48
AVE. BODY WT
REL. TO CNTL 0.80 0.82 0.82 0.82 0.81 0.80 0.81 0.82 0.82 0.82 0.82 0.82 0.82
(TRT#: 1 )
BLANK MISSING DATA @ ANIMAL REMOVED FROM STUDY
() TRT# OF THE CONTROL GROUP USED IN CALCULATION * MULTIPLE OBSERVATIONS, LAST WEIGHT DISPLAYED
NTP EXP/TEST: 92013-05 4-METHYLIMIDAZOLE PAGE: 48
TEST TYPE: CHRONIC INDIVIDUAL BODY WEIGHT TABLE DATE: 11/29/04
ROUTE: DOSED FEED EISRPT12 TIME: 09:48:49
----------------------------------------------------------------------------------------------------------------------------------
SPECIES-STRAIN: RATS-F 344 SEX: MALE TRT: 2500 PPM TRT#: 7 FIRST-DOSE: 01/20/00
----------------------------------------------------------------------------------------------------------------------------------
CAGE ANIMAL DAY ON DOSE
NO ID 481 509 537 565 593 621 649 677 705
----------------------------------------------------------------------------------------------------------------------------------
52 151 372.8 366.5 369.9 374.4 355.9 222.2 @
52 152 365.5 355.5 358.3 366.5 355.1 349.0 324.4 257.4 @
52 153 410.6 398.6 400.1 403.9 386.2 387.0 391.4 383.6 367.3
53 154 383.5 381.4 376.3 370.9 363.6 363.3 279.3 @
53 155 347.2 340.8 338.3 335.0 336.7 339.0 339.5 319.9 312.2
53 156
54 157 392.8 389.6 388.6 388.0 385.3 383.1 383.3 385.4 378.3
54 158 366.1 367.4 344.6 358.8 356.6 356.9 353.1 353.4 341.8
54 159 357.7 366.7 338.6 360.9 354.6 355.5 346.6 353.8 349.9
55 160 363.2 364.8 350.4 353.3 355.5 347.5 343.8 359.0 346.2
55 161 343.8 340.3 334.9 338.3 334.5 333.3 335.1 337.9 336.1
55 162 373.2 373.1 365.4 373.1 369.6 363.8 364.8 375.1 370.4
56 163 377.5 376.9 370.4 380.1 381.0 379.6 375.5 365.3 360.1
56 164 369.4 369.7 359.4 368.3 360.4 353.9 351.7 347.6 336.3
56 165 369.7 371.3 368.4 376.6 377.4 367.8 @
57 166 347.1 371.9 361.5 367.7 359.5 342.0 333.8 324.7 @
57 167
57 168 346.8 380.3 384.1 387.4 369.9 @
58 169 371.2 361.7 364.2 365.1 361.5 360.8 359.1 297.5 342.4
58 170 367.4 359.2 358.3 352.7 346.5 346.6 349.0 288.2 332.9
58 171 369.1 365.5 366.4 370.5 366.1 367.2 371.9 @
59 172 400.8 394.3 398.2 395.3 390.6 391.9 390.9 398.4 390.7
59 173 386.5 379.0 385.4 375.5 372.3 378.1 369.9 375.2 362.7
59 174 377.3 373.6 378.1 368.2 367.5 363.5 364.5 365.2 357.9
60 175 360.2 361.6 362.3 252.0 @
60 176 359.9 367.6 367.4 363.7 357.9 353.3 350.9 346.4 339.8
60 177 347.6 348.5 346.2 338.6 337.3 339.0 338.2 337.6 327.5
61 178 377.3 379.5 378.7 375.4 376.7 375.6 366.9 365.4 354.9
61 179 380.2 377.2 383.1 377.7 380.0 376.8 376.4 376.3 368.7
61 180 368.1 370.6 379.8 367.9 359.3 361.7 254.7 @
62 181 344.5 345.9 347.1 345.7 341.0 312.8 281.8 @
62 182 389.5 389.4 387.1 389.4 394.4 387.5 358.7 @
62 183 342.8 341.5 350.4 347.7 353.1 344.5 344.8 328.1 322.6
63 184 382.8 375.1 380.8 380.5 376.0 374.6 380.6 365.4 365.3
63 185 348.7 346.0 344.2 341.0 338.0 336.3 334.1 330.1 321.7
63 186 395.6 395.2 394.4 392.8 390.4 395.2 393.9 388.5 379.1
64 187 365.3 360.9 365.9 362.9 380.4 386.7 @
64 188 364.3 367.4 370.4 365.0 362.0 365.6 353.0 347.8 343.5
64 189 360.4 355.1 360.0 355.9 347.4 263.2 @
65 190 371.2 369.3 372.2 374.8 369.8 362.2 366.7 369.2 359.3
65 191 329.0 333.4 343.8 345.3 339.0 331.5 331.0 331.6 325.1
65 192 372.3 369.9 375.9 377.1 372.3 370.5 366.0 373.7 362.2
66 193 356.9 357.0 357.6 356.0 358.8 349.1 345.1 355.7 340.7
66 194 363.2 359.8 337.5 363.8 361.8 354.0 325.6 @
66 195 359.5 367.2 353.6 365.1 356.1 359.5 357.8 365.4 358.6
67 196 370.4 364.3 365.5 361.9 363.2 356.3 352.9 350.8 346.6
67 197 371.9 363.0 371.2 370.5 362.8 353.7 355.9 365.5 354.4
NTP EXP/TEST: 92013-05 4-METHYLIMIDAZOLE PAGE: 49
TEST TYPE: CHRONIC INDIVIDUAL BODY WEIGHT TABLE DATE: 11/29/04
ROUTE: DOSED FEED EISRPT12 TIME: 09:48:49
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SPECIES-STRAIN: RATS-F 344 SEX: MALE TRT: 2500 PPM TRT#: 7 FIRST-DOSE: 01/20/00
----------------------------------------------------------------------------------------------------------------------------------
CAGE ANIMAL DAY ON DOSE
NO ID 481 509 537 565 593 621 649 677 705
----------------------------------------------------------------------------------------------------------------------------------
67 198 350.9 347.3 347.2 346.6 340.7 326.4 306.1 @
68 199 364.4 360.5 357.4 358.6 346.9 344.9 336.3 299.4 @
68 200 366.1 358.7 360.1 360.3 357.6 353.7 350.8 354.9 332.8
----- ----- ----- ----- ----- ----- ----- ----- -----
MEAN WT(G) 367.1 366.3 365.0 363.9 362.3 354.1 348.9 349.7 349.6
SD 16.2 14.7 16.5 22.6 15.5 30.3 29.1 30.4 18.6
NO. OBSER. 48 48 48 48 47 46 42 35 32
AVE. BODY WT
REL. TO CNTL 0.82 0.83 0.83 0.83 0.84 0.84 0.82 0.83 0.87
(TRT#: 1 )
BLANK MISSING DATA @ ANIMAL REMOVED FROM STUDY
() TRT# OF THE CONTROL GROUP USED IN CALCULATION * MULTIPLE OBSERVATIONS, LAST WEIGHT DISPLAYED
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