TDMS Study 92013-05 Pathology Tables
NTP MEAN BODY WEIGHTS AND SURVIVAL TABLE REPORT: EISRPT41
LAB: Southern Research Inst 4-METHYLIMIDAZOLE DATE: 11/29/04
EXPERIMENT: 92013 TEST: 05 TIME: 09:47:10
CAGES FROM 0000 TO LAST CAGE PAGE: 1
TEST TYPE: CHRONIC ROUTE: DOSED FEED NTP: C92013B
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REASONS FOR REMOVAL: ALL
REMOVAL DATE RANGE: ALL
TREATMENT GROUPS: INCLUDE ALL
NTP MEAN BODY WEIGHTS AND SURVIVAL TABLE REPORT: EISRPT41
LAB: SOUTHERN RESEARCH INSTITUTE 4-METHYLIMIDAZOLE DATE: 11/29/04
EXPERIMENT: 92013 TEST: 05 TIME: 9:54:03
SPECIES: RATS, FISCHER 344
TEST TYPE: TWO YEAR ROUTE: DOSED FEED NTP: 92013B
CONT: N01-ES-85420 CAS: 822-36-6
MEAN BODY WEIGHTS AND SURVIVAL OF MALE RATS IN THE
TWO YEAR DOSED FEED STUDY OF 4-METHYLIMIDAZOLE
==========================================================================================================
WEEK 0 PPM 625 PPM 1250 PPM 2500 PPM
---------------- ---------------- ---------------- ----------------
AV.WT. NO. AV.WT. PERCENT NO. AV.WT. PERCENT NO. AV.WT. PERCENT NO.
(GRAMS) (A) (GRAMS) OF CNTL (A) (GRAMS) OF CNTL (A) (GRAMS) OF CNTL (A)
=========================================================================================================
B 124.2 50 123.6 99.5 50 123.0 99.0 50 124.2 100.0 50
1 124.2 50 123.6 99.5 50 123.0 99.0 50 124.2 100.0 50
2 179.2 50 173.4 96.8 50 165.1 92.1 50 150.5 84.0 50
3 209.8 50 204.5 97.5 50 193.4 92.2 50 180.1 85.8 50
4 240.4 50 234.8 97.7 50 221.4 92.1 50 205.0 85.3 50
5 255.0 50 250.2 98.1 50 237.3 93.1 50 222.7 87.3 50
6 269.7 50 266.0 98.6 50 252.3 93.5 50 238.7 88.5 50
7 285.9 50 279.8 97.9 50 264.5 92.5 50 250.4 87.6 50
8 304.2 50 297.2 97.7 50 280.1 92.1 50 262.1 86.2 50
9 313.3 50 306.8 97.9 50 288.2 92.0 50 270.2 86.2 50
10 324.3 50 317.2 97.8 50 295.1 91.0 50 277.8 85.7 50
11 329.6 50 321.0 97.4 50 296.7 90.0 50 279.9 84.9 50
12 341.7 50 330.6 96.8 50 303.8 88.9 50 284.8 83.3 50
13 345.3 50 331.7 96.1 50 303.2 87.8 50 283.6 82.1 50
17 365.2 50 352.4 96.5 50 322.2 88.2 50 291.8 79.9 50
21 382.3 50 367.5 96.1 50 340.3 89.0 50 312.9 81.8 50
25 395.3 50 382.5 96.8 50 350.9 88.8 50 323.1 81.7 50
29 410.4 50 395.7 96.4 50 363.2 88.5 50 335.9 81.8 50
33 417.5 50 402.3 96.4 50 369.8 88.6 50 339.9 81.4 50
37 425.9 50 408.0 95.8 50 379.4 89.1 50 342.7 80.5 50
41 428.8 50 414.6 96.7 48 379.7 88.5 50 349.0 81.4 50
45 432.7 50 419.0 96.8 48 383.8 88.7 50 352.9 81.6 50
49 437.3 50 421.4 96.4 48 385.0 88.0 50 356.8 81.6 50
53 439.5 50 428.9 97.6 48 385.7 87.8 50 358.5 81.6 50
57 437.9 50 424.5 96.9 48 390.1 89.1 50 358.9 82.0 48
61 444.7 50 428.1 96.3 48 395.7 89.0 50 364.0 81.9 48
65 448.0 50 435.0 97.1 48 395.6 88.3 50 366.4 81.8 48
69 445.3 49 430.2 96.6 47 401.9 90.3 50 367.1 82.4 48
73 443.5 49 423.9 95.6 47 395.4 89.2 48 366.3 82.6 48
77 438.3 49 424.6 96.9 46 395.6 90.3 47 365.0 83.3 48
81 437.8 48 419.1 95.7 45 386.4 88.3 46 363.9 83.1 48
85 432.8 46 416.1 96.1 42 388.4 89.7 46 362.3 83.7 47
89 421.2 45 408.3 96.9 41 386.5 91.8 44 354.1 84.1 46
93 425.8 44 414.4 97.3 40 383.0 89.9 41 348.9 81.9 42
97 422.1 41 408.2 96.7 39 381.2 90.3 39 349.7 82.8 35
101 400.2 36 405.2 101.2 35 378.1 94.5 36 349.6 87.4 32
TERM. SAC. 31 34 33 32
==========================================================================================================
(A) NUMBER OF ANIMALS WEIGHED. AT TERMINAL SACRIFICE, NUMBER
OF ANIMALS ALIVE ON FIRST DAY OF TERMINAL SACRIFICE.
(B) REFERS TO THE BEGINNING (INITIAL) BODY WEIGHT.
(I) INTERIM SACRIFICE OCCURRED IN THIS WEEK.
(*) THE NUMBER OF ANIMALS WEIGHED FOR THIS WEEK
IS LESS THAN THE NUMBER OF ANIMALS SURVIVING.
MEAN BODY WEIGHTS AND SURVIVAL OF FEMALE RATS IN THE
TWO YEAR DOSED FEED STUDY OF 4-METHYLIMIDAZOLE
==========================================================================================================
WEEK 0 PPM 1250 PPM 2500 PPM 5000 PPM
---------------- ---------------- ---------------- ----------------
AV.WT. NO. AV.WT. PERCENT NO. AV.WT. PERCENT NO. AV.WT. PERCENT NO.
(GRAMS) (A) (GRAMS) OF CNTL (A) (GRAMS) OF CNTL (A) (GRAMS) OF CNTL (A)
=========================================================================================================
B 100.1 50 97.9 97.8 50 99.5 99.4 50 99.0 98.9 50
1 100.1 50 97.9 97.8 50 99.5 99.4 50 99.0 98.9 50
2 127.4 50 124.2 97.5 50 118.3 92.9 50 96.0 75.4 50
3 138.4 49 137.0 99.0 50 132.8 96.0 50 109.3 79.0 50
4 148.7 49 148.1 99.6 50 143.5 96.5 50 117.9 79.3 50
5 155.5 49 154.9 99.6 50 152.3 97.9 50 125.8 80.9 50
6 163.1 49 161.9 99.3 50 161.1 98.8 50 132.4 81.2 50
7 168.7 49 166.0 98.4 50 166.3 98.6 50 136.8 81.1 50
8 176.0 49 172.4 98.0 50 171.8 97.6 50 141.6 80.5 50
9 177.2 49 173.4 97.9 50 174.6 98.5 50 143.3 80.9 50
10 181.6 49 175.6 96.7 50 178.2 98.1 50 145.2 80.0 50
11 185.8 49 178.3 96.0 50 179.9 96.8 50 146.1 78.6 50
12 186.5 49 179.6 96.3 50 180.5 96.8 50 148.5 79.6 50
13 189.7 49 182.1 96.0 50 181.0 95.4 50 151.7 80.0 50
17 194.4 49 188.9 97.2 50 188.9 97.2 49 153.8 79.1 50
21 203.9 49 194.4 95.3 50 193.3 94.8 49 157.7 77.3 50
25 211.8 49 202.4 95.6 50 201.6 95.2 49 163.9 77.4 50
29 217.3 49 208.8 96.1 50 202.8 93.3 49 166.7 76.7 50
33 223.1 49 214.9 96.3 50 209.0 93.7 49 171.8 77.0 50
37 228.5 49 218.3 95.5 50 214.5 93.9 49 173.9 76.1 50
41 227.7 49 220.3 96.8 50 216.3 95.0 49 177.5 78.0 50
45 238.4 48 223.4 93.7 50 217.4 91.2 49 178.9 75.0 50
49 242.4 48 227.3 93.8 50 221.4 91.3 49 183.3 75.6 49
53 250.6 48 231.9 92.5 50 223.5 89.2 49 186.6 74.5 48
57 254.7 48 234.1 91.9 50 224.1 88.0 48 187.4 73.6 48
61 270.1 48 239.0 88.5 49 227.3 84.2 48 193.4 71.6 48
65 275.4 48 243.9 88.6 48 230.8 83.8 48 194.5 70.6 48
69 278.2 48 247.8 89.1 47 231.6 83.2 48 192.1 69.1 48
73 284.1 47 248.4 87.4 47 233.2 82.1 48 195.1 68.7 48
77 290.5 47 254.4 87.6 46 237.2 81.7 48 197.0 67.8 48
81 296.4 47 255.5 86.2 46 236.8 79.9 46 200.4 67.6 45
85 297.1 47 257.5 86.7 46 241.0 81.1 44 197.3 66.4 45
89 301.2 47 257.9 85.6 46 243.6 80.9 43 200.3 66.5 45
93 305.2 46 259.2 84.9 45 247.2 81.0 40 202.4 66.3 42
97 299.5 45 264.8 88.4 42 250.1 83.5 38 202.7 67.7 40
101 311.3 43 263.5 84.6 40 253.3 81.4 35 202.1 64.9 37
TERM. SAC. 43 39 34 35
==========================================================================================================
(A) NUMBER OF ANIMALS WEIGHED. AT TERMINAL SACRIFICE, NUMBER
OF ANIMALS ALIVE ON FIRST DAY OF TERMINAL SACRIFICE.
(B) REFERS TO THE BEGINNING (INITIAL) BODY WEIGHT.
(I) INTERIM SACRIFICE OCCURRED IN THIS WEEK.
(*) THE NUMBER OF ANIMALS WEIGHED FOR THIS WEEK
IS LESS THAN THE NUMBER OF ANIMALS SURVIVING.