TDMS Study 93020-05 Pathology Tables
NTP Experiment-Test: 93020-05 INCIDENCE RATES OF NEOPLASMS BY ANATOMIC SITE (a) Report: PEIRPT02
Study Type: 150-DAY DIISOPROPYLCARBODIIMIDE Date: 08/19/97
Route: SKIN APPLICATION Time: 14:04:40
150 DAY SUBCHRONIC
Facility: Microbiological Associates
Chemical CAS #: 693-13-0
Lock Date: 03/26/96
Cage Range: All
Reasons For Removal: All
Removal Date Range: All
Treatment Groups: Include All
a Number of animals examined microscopically at site and number of animals with lesion
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NTP Experiment-Test: 93020-05 INCIDENCE RATES OF NEOPLASMS BY ANATOMIC SITE (a) Report: PEIRPT02
Study Type: 150-DAY DIISOPROPYLCARBODIIMIDE Date: 08/19/97
Route: SKIN APPLICATION Time: 14:04:40
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TG.AC HETEROZYGOUS TRANSGENIC MICE FEMALE 0 4.38 8.75 17.5 35 70
MG/KG MG/KG MG/KG MG/KG MG/KG MG/KG
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DISPOSITION SUMMARY
Animals Initially in Study 10 10 10 10 10 10
Early Deaths
Natural Death 1 1 2
Moribund Sacrifice 1 2 2 1 2
Survivors
Terminal Sacrifice 8 8 8 8 6 10
Animals Examined Microscopically 10 8 10 9 9 10
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ALIMENTARY SYSTEM
Intestine Small, Jejunum (9) (2) (2) (1) (2) (10)
Carcinoma 1 (11%)
Liver (10) (6) (7) (7) (6) (10)
Leukemia Erythrocytic 1 (10%)
Salivary Glands (10) (2) (2) (2) (4) (10)
Duct, Squamous Cell Carcinoma 1 (25%)
Stomach, Forestomach (10) (2) (3) (3) (2) (10)
Squamous Cell Papilloma 2 (67%) 2 (67%) 2 (20%)
Tooth (3) (4) (4) (6) (3) (7)
Odontoma 3 (100%) 2 (50%) 4 (100%) 6 (100%) 1 (33%) 6 (86%)
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CARDIOVASCULAR SYSTEM
None
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ENDOCRINE SYSTEM
None
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GENERAL BODY SYSTEM
None
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GENITAL SYSTEM
Ovary (10) (2) (2) (2) (4) (10)
Teratoma Benign 2 (50%)
Yolk Sac Carcinoma 1 (50%)
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NTP Experiment-Test: 93020-05 INCIDENCE RATES OF NEOPLASMS BY ANATOMIC SITE (a) Report: PEIRPT02
Study Type: 150-DAY DIISOPROPYLCARBODIIMIDE Date: 08/19/97
Route: SKIN APPLICATION Time: 14:04:40
____________________________________________________________________________________________________________________________________
TG.AC HETEROZYGOUS TRANSGENIC MICE FEMALE 0 4.38 8.75 17.5 35 70
MG/KG MG/KG MG/KG MG/KG MG/KG MG/KG
____________________________________________________________________________________________________________________________________
HEMATOPOIETIC SYSTEM
Spleen (9) (5) (3) (3) (6) (10)
Leukemia Erythrocytic 1 (11%)
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INTEGUMENTARY SYSTEM
Skin (10) (3) (4) (4) (4) (10)
Squamous Cell Papilloma 1 (33%) 1 (25%)
Squamous Cell Papilloma, Multiple 1 (10%) 1 (25%)
Dermis, Skin, Site of Application,
Fibrosarcoma 1 (25%)
Skin, Site of Application, Squamous Cell
Papilloma 1 (10%)
Skin, Site of Application, Squamous Cell
Papilloma, Multiple 1 (10%) 1 (25%) 1 (25%)
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MUSCULOSKELETAL SYSTEM
None
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NERVOUS SYSTEM
None
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RESPIRATORY SYSTEM
Nose (10) (5) (1) (2) (4) (10)
Respiratory Epithelium, Adenoma 1 (10%)
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SPECIAL SENSES SYSTEM
None
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URINARY SYSTEM
None
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NTP Experiment-Test: 93020-05 INCIDENCE RATES OF NEOPLASMS BY ANATOMIC SITE (a) Report: PEIRPT02
Study Type: 150-DAY DIISOPROPYLCARBODIIMIDE Date: 08/19/97
Route: SKIN APPLICATION Time: 14:04:40
____________________________________________________________________________________________________________________________________
TG.AC HETEROZYGOUS TRANSGENIC MICE FEMALE 0 4.38 8.75 17.5 35 70
MG/KG MG/KG MG/KG MG/KG MG/KG MG/KG
____________________________________________________________________________________________________________________________________
SYSTEMIC LESIONS
Multiple Organs *(10) *(8) *(10) *(9) *(9) *(10)
Leukemia Erythrocytic 1 (10%)
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* Number of animals with any tissue examined microscopically
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NTP Experiment-Test: 93020-05 INCIDENCE RATES OF NEOPLASMS BY ANATOMIC SITE (a) Report: PEIRPT02
Study Type: 150-DAY DIISOPROPYLCARBODIIMIDE Date: 08/19/97
Route: SKIN APPLICATION Time: 14:04:40
____________________________________________________________________________________________________________________________________
TG.AC HETEROZYGOUS TRANSGENIC MICE FEMALE 0 4.38 8.75 17.5 35 70
MG/KG MG/KG MG/KG MG/KG MG/KG MG/KG
____________________________________________________________________________________________________________________________________
TUMOR SUMMARY
Total Animals with Primary Neoplasms (b) 6 3 6 7 3 8
Total Primary Neoplasms 8 3 10 10 4 9
Total Animals with Benign Neoplasms 5 3 6 7 3 8
Total Benign Neoplasms 6 3 8 10 3 9
Total Animals with Malignant Neoplasms 2 2 1
Total Malignant Neoplasms 2 2 1
Total Animals with Metastatic Neoplasms
Total Metastatic Neoplasm
Total Animals with Malignant Neoplasms
Uncertain Primary Site
Total Animals with Neoplasms Uncertain-
Benign or Malignant
Total Uncertain Neoplasms
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a Number of animals examined microscopically at site and number of animals with lesion
b Primary tumors: all tumors except metastatic tumors
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