TDMS Study 93020-05 Pathology Tables
NTP Experiment-Test: 93020-05 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: 150-DAY DIISOPROPYLCARBODIIMIDE Date: 08/19/97
Route: SKIN APPLICATION Time: 14:05:56
150 DAY SUBCHRONIC
Facility: Microbiological Associates
Chemical CAS #: 693-13-0
Lock Date: 03/26/96
Cage Range: All
Reasons For Removal: All
Removal Date Range: All
Treatment Groups: Include All
Page 1
NTP Experiment-Test: 93020-05 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: 150-DAY DIISOPROPYLCARBODIIMIDE Date: 08/19/97
Route: SKIN APPLICATION Time: 14:05:56
__________________________________________________________________________________________________________________________________
| 1| 1| 0| 1| 1| 1| 1| 1| 1| 1| | |
DAY ON TEST | 4| 4| 9| 4| 4| 1| 4| 4| 4| 4| | |
| 1| 1| 7| 1| 1| 1| 1| 1| 1| 1| | T (*) |
_____________________________________________________________________________________________________________________| |
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | O |
TG.AC HETEROZYGOUS TRANSGENIC FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | T |
ANIMAL ID | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | A |
0 | 0| 0| 0| 0| 0| 0| 0| 0| 0| 1| | L |
MG/KG | 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| | |
__________________________________________________________________________________________________________________________________
ALIMENTARY SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Esophagus | + + + + + + + + + + | 10 |
__________________________________________________________________________|____________|
Gallbladder | + M A + M + + M + + | 6 |
__________________________________________________________________________|____________|
Intestine Large, Colon | + + A + + + + + + + | 9 |
__________________________________________________________________________|____________|
Intestine Large, Rectum | + + A + + + + + + + | 9 |
__________________________________________________________________________|____________|
Intestine Large, Cecum | + + A + + + + + + + | 9 |
__________________________________________________________________________|____________|
Intestine Small, Duodenum | + + A + + + + + + + | 9 |
__________________________________________________________________________|____________|
Intestine Small, Jejunum | + + A + + + + + + + | 9 |
Ulcer, Chronic Active | 4 | 1 4.0|
__________________________________________________________________________|____________|
Intestine Small, Ileum | + + A + + + + + + + | 9 |
__________________________________________________________________________|____________|
Liver | + + + + + + + + + + | 10 |
Hematopoietic Cell Proliferation | 3 | 1 3.0|
Inflammation, Focal | 1 1 3 2 1 2 2 | 7 1.7|
Necrosis | 4 | 1 4.0|
__________________________________________________________________________|____________|
Pancreas | + + A + + + + + + + | 9 |
Inflammation, Focal | 2 | 1 2.0|
__________________________________________________________________________|____________|
Salivary Glands | + + + + + + + + + + | 10 |
__________________________________________________________________________|____________|
Stomach, Forestomach | + + + + + + + + + + | 10 |
__________________________________________________________________________|____________|
Stomach, Glandular | + + + + + + + + + + | 10 |
__________________________________________________________________________|____________|
Tooth | + + + | 3 |
_____________________________________________________________________________________________________________________| |
CARDIOVASCULAR SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Blood Vessel | + + + + + + + + + + | 10 |
Aorta, Adventitia, Inflammation, | | |
Focal | 3 | 1 3.0|
__________________________________________________________________________|____________|
Heart | + + + + + + + + + + | 10 |
_____________________________________________________________________________________________________________________| |
ENDOCRINE SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Adrenal Cortex | + + + + + + + + + + | 10 |
__________________________________________________________________________|____________|
Adrenal Medulla | + + + + + + + + + + | 10 |
__________________________________________________________________________|____________|
Islets, Pancreatic | + + + + + + + + + + | 10 |
__________________________________________________________________________|____________|
Parathyroid Gland | + + M + M M M M M + | 4 |
__________________________________________________________________________|____________|
Pituitary Gland | + + I + + M + + + + | 8 |
__________________________________________________________________________|____________|
Thyroid Gland | + + + + + + + + + + | 10 |
_____________________________________________________________________________________________________________________| |
GENERAL BODY SYSTEM | | |
| | |
None | | |
_____________________________________________________________________________________________________________________| |
GENITAL SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Clitoral Gland | M + + M + + M + + + | 7 |
__________________________________________________________________________________________________________________________________
* : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade
+ : Tissue examined microscopically M : Missing tissue 1-4 : Lesion qualified as:
X : Lesion present but not qualified A : Autolysis precludes examination 1) Minimal 3) Moderate
I : Insufficient tissue BLANK : Not examined 2) Mild 4) Marked
Page 2
NTP Experiment-Test: 93020-05 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: 150-DAY DIISOPROPYLCARBODIIMIDE Date: 08/19/97
Route: SKIN APPLICATION Time: 14:05:56
__________________________________________________________________________________________________________________________________
| 1| 1| 0| 1| 1| 1| 1| 1| 1| 1| | |
DAY ON TEST | 4| 4| 9| 4| 4| 1| 4| 4| 4| 4| | |
| 1| 1| 7| 1| 1| 1| 1| 1| 1| 1| | T (*) |
_____________________________________________________________________________________________________________________| |
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | O |
TG.AC HETEROZYGOUS TRANSGENIC FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | T |
ANIMAL ID | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | A |
0 | 0| 0| 0| 0| 0| 0| 0| 0| 0| 1| | L |
MG/KG | 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| | |
__________________________________________________________________________________________________________________________________
GENITAL SYSTEM - cont | | |
| | |
__________________________________________________________________________|____________|
Ovary | + + + + + + + + + + | 10 |
__________________________________________________________________________|____________|
Uterus | + + + + + + + + + + | 10 |
Hydrometra | 1 | 1 1.0|
Bilateral, Hydrometra | 1 2 | 2 1.5|
_____________________________________________________________________________________________________________________| |
HEMATOPOIETIC SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Bone Marrow | + + + + + + + + + + | 10 |
Myeloid Cell, Hyperplasia | 3 | 1 3.0|
__________________________________________________________________________|____________|
Lymph Node, Mandibular | + + + + + + + + + + | 10 |
Infiltration Cellular, Plasma Cell | 3 | 1 3.0|
Infiltration Cellular, | | |
Polymorphonuclear | 3 | 1 3.0|
__________________________________________________________________________|____________|
Lymph Node, Mesenteric | + + + + + + M + + + | 9 |
Infiltration Cellular, | | |
Polymorphonuclear | 3 | 1 3.0|
Infiltration Cellular, Histiocyte | 2 | 1 2.0|
__________________________________________________________________________|____________|
Spleen | + + A + + + + + + + | 9 |
Hematopoietic Cell Proliferation | 2 3 3 3 2 2 2 | 7 2.4|
__________________________________________________________________________|____________|
Thymus | + + + + + M + + + + | 9 |
Atrophy | 3 | 1 3.0|
Thymocyte, Necrosis | 2 | 1 2.0|
_____________________________________________________________________________________________________________________| |
INTEGUMENTARY SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Mammary Gland | + + M + + + + + + + | 9 |
__________________________________________________________________________|____________|
Skin | + + + + + + + + + + | 10 |
_____________________________________________________________________________________________________________________| |
MUSCULOSKELETAL SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Bone | + + + + + + + + + + | 10 |
_____________________________________________________________________________________________________________________| |
NERVOUS SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Brain | + + + + + + + + + + | 10 |
_____________________________________________________________________________________________________________________| |
RESPIRATORY SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Lung | + + + + + + + + + + | 10 |
Inflammation, Chronic, Focal | 2 | 1 2.0|
Inflammation, Focal | 2 1 | 2 1.5|
__________________________________________________________________________|____________|
Nose | + + + + + + + + + + | 10 |
Inflammation | 2 2 | 2 2.0|
__________________________________________________________________________|____________|
Trachea | + + + + + + + + + + | 10 |
__________________________________________________________________________________________________________________________________
* : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade
+ : Tissue examined microscopically M : Missing tissue 1-4 : Lesion qualified as:
X : Lesion present but not qualified A : Autolysis precludes examination 1) Minimal 3) Moderate
I : Insufficient tissue BLANK : Not examined 2) Mild 4) Marked
Page 3
NTP Experiment-Test: 93020-05 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: 150-DAY DIISOPROPYLCARBODIIMIDE Date: 08/19/97
Route: SKIN APPLICATION Time: 14:05:56
__________________________________________________________________________________________________________________________________
| 1| 1| 0| 1| 1| 1| 1| 1| 1| 1| | |
DAY ON TEST | 4| 4| 9| 4| 4| 1| 4| 4| 4| 4| | |
| 1| 1| 7| 1| 1| 1| 1| 1| 1| 1| | T (*) |
_____________________________________________________________________________________________________________________| |
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | O |
TG.AC HETEROZYGOUS TRANSGENIC FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | T |
ANIMAL ID | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | A |
0 | 0| 0| 0| 0| 0| 0| 0| 0| 0| 1| | L |
MG/KG | 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| | |
__________________________________________________________________________________________________________________________________
SPECIAL SENSES SYSTEM | | |
| | |
None | | |
_____________________________________________________________________________________________________________________| |
URINARY SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Kidney | + + + + + + + + + + | 10 |
__________________________________________________________________________|____________|
Urinary Bladder | + + + + + + + + + + | 10 |
__________________________________________________________________________________________________________________________________
* : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade
+ : Tissue examined microscopically M : Missing tissue 1-4 : Lesion qualified as:
X : Lesion present but not qualified A : Autolysis precludes examination 1) Minimal 3) Moderate
I : Insufficient tissue BLANK : Not examined 2) Mild 4) Marked
Page 4
NTP Experiment-Test: 93020-05 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: 150-DAY DIISOPROPYLCARBODIIMIDE Date: 08/19/97
Route: SKIN APPLICATION Time: 14:05:56
__________________________________________________________________________________________________________________________________
| 1| 1| 1| 0| 1| 1| 1| 1| 1| 1| | |
DAY ON TEST | 4| 4| 4| 9| 4| 4| 4| 4| 3| 4| | |
| 1| 1| 1| 3| 1| 1| 1| 1| 8| 1| | T (*) |
_____________________________________________________________________________________________________________________| |
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | O |
TG.AC HETEROZYGOUS TRANSGENIC FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | T |
ANIMAL ID | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | A |
4.38 | 1| 1| 1| 1| 1| 1| 1| 1| 1| 2| | L |
MG/KG | 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| | |
__________________________________________________________________________________________________________________________________
ALIMENTARY SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Esophagus | + + | 2 |
__________________________________________________________________________|____________|
Gallbladder | + + | 2 |
__________________________________________________________________________|____________|
Intestine Large, Colon | + + | 2 |
__________________________________________________________________________|____________|
Intestine Large, Rectum | + + | 2 |
__________________________________________________________________________|____________|
Intestine Large, Cecum | + + | 2 |
__________________________________________________________________________|____________|
Intestine Small, Duodenum | + + | 2 |
__________________________________________________________________________|____________|
Intestine Small, Jejunum | + + | 2 |
__________________________________________________________________________|____________|
Intestine Small, Ileum | + + | 2 |
__________________________________________________________________________|____________|
Liver | + + + + + + | 6 |
Inflammation, Focal | 2 1 1 1 | 4 1.3|
__________________________________________________________________________|____________|
Pancreas | + + | 2 |
__________________________________________________________________________|____________|
Salivary Glands | + + | 2 |
__________________________________________________________________________|____________|
Stomach, Forestomach | + + | 2 |
__________________________________________________________________________|____________|
Stomach, Glandular | + + | 2 |
__________________________________________________________________________|____________|
Tooth | + + + + | 4 |
_____________________________________________________________________________________________________________________| |
CARDIOVASCULAR SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Blood Vessel | + + | 2 |
__________________________________________________________________________|____________|
Heart | + + | 2 |
_____________________________________________________________________________________________________________________| |
ENDOCRINE SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Adrenal Cortex | + + + + | 4 |
__________________________________________________________________________|____________|
Adrenal Medulla | + + | 2 |
__________________________________________________________________________|____________|
Islets, Pancreatic | + + | 2 |
__________________________________________________________________________|____________|
Parathyroid Gland | M M | |
__________________________________________________________________________|____________|
Pituitary Gland | + + | 2 |
__________________________________________________________________________|____________|
Thyroid Gland | + + | 2 |
_____________________________________________________________________________________________________________________| |
GENERAL BODY SYSTEM | | |
| | |
None | | |
_____________________________________________________________________________________________________________________| |
GENITAL SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Clitoral Gland | + + | 2 |
Atrophy | 3 | 1 3.0|
__________________________________________________________________________|____________|
Ovary | + + | 2 |
__________________________________________________________________________|____________|
Uterus | + + | 2 |
_____________________________________________________________________________________________________________________| |
HEMATOPOIETIC SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Bone Marrow | + + | 2 |
__________________________________________________________________________________________________________________________________
* : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade
+ : Tissue examined microscopically M : Missing tissue 1-4 : Lesion qualified as:
X : Lesion present but not qualified A : Autolysis precludes examination 1) Minimal 3) Moderate
I : Insufficient tissue BLANK : Not examined 2) Mild 4) Marked
Page 5
NTP Experiment-Test: 93020-05 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: 150-DAY DIISOPROPYLCARBODIIMIDE Date: 08/19/97
Route: SKIN APPLICATION Time: 14:05:56
__________________________________________________________________________________________________________________________________
| 1| 1| 1| 0| 1| 1| 1| 1| 1| 1| | |
DAY ON TEST | 4| 4| 4| 9| 4| 4| 4| 4| 3| 4| | |
| 1| 1| 1| 3| 1| 1| 1| 1| 8| 1| | T (*) |
_____________________________________________________________________________________________________________________| |
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | O |
TG.AC HETEROZYGOUS TRANSGENIC FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | T |
ANIMAL ID | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | A |
4.38 | 1| 1| 1| 1| 1| 1| 1| 1| 1| 2| | L |
MG/KG | 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| | |
__________________________________________________________________________________________________________________________________
HEMATOPOIETIC SYSTEM - cont | | |
| | |
__________________________________________________________________________|____________|
Lymph Node, Mandibular | + + | 2 |
__________________________________________________________________________|____________|
Lymph Node, Mesenteric | + + | 2 |
Pigmentation | 2 | 1 2.0|
__________________________________________________________________________|____________|
Spleen | + + + + + | 5 |
Hematopoietic Cell Proliferation | 3 2 2 2 1 | 5 2.0|
__________________________________________________________________________|____________|
Thymus | + + | 2 |
Atrophy | 3 4 | 2 3.5|
_____________________________________________________________________________________________________________________| |
INTEGUMENTARY SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Mammary Gland | + + | 2 |
__________________________________________________________________________|____________|
Skin | + + + | 3 |
_____________________________________________________________________________________________________________________| |
MUSCULOSKELETAL SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Bone | + + | 2 |
_____________________________________________________________________________________________________________________| |
NERVOUS SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Brain | + + | 2 |
_____________________________________________________________________________________________________________________| |
RESPIRATORY SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Lung | + + | 2 |
__________________________________________________________________________|____________|
Nose | + + + + + | 5 |
Inflammation | 3 3 1 | 3 2.3|
__________________________________________________________________________|____________|
Trachea | + + | 2 |
_____________________________________________________________________________________________________________________| |
SPECIAL SENSES SYSTEM | | |
| | |
None | | |
_____________________________________________________________________________________________________________________| |
URINARY SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Kidney | + + | 2 |
__________________________________________________________________________|____________|
Urinary Bladder | + + | 2 |
__________________________________________________________________________________________________________________________________
* : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade
+ : Tissue examined microscopically M : Missing tissue 1-4 : Lesion qualified as:
X : Lesion present but not qualified A : Autolysis precludes examination 1) Minimal 3) Moderate
I : Insufficient tissue BLANK : Not examined 2) Mild 4) Marked
Page 6
NTP Experiment-Test: 93020-05 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: 150-DAY DIISOPROPYLCARBODIIMIDE Date: 08/19/97
Route: SKIN APPLICATION Time: 14:05:56
__________________________________________________________________________________________________________________________________
| 1| 1| 1| 0| 1| 1| 1| 1| 1| 1| | |
DAY ON TEST | 4| 4| 3| 9| 4| 4| 4| 4| 4| 4| | |
| 1| 1| 3| 9| 1| 1| 1| 1| 1| 1| | T (*) |
_____________________________________________________________________________________________________________________| |
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | O |
TG.AC HETEROZYGOUS TRANSGENIC FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | T |
ANIMAL ID | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | A |
8.75 | 2| 2| 2| 2| 2| 2| 2| 2| 2| 3| | L |
MG/KG | 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| | |
__________________________________________________________________________________________________________________________________
ALIMENTARY SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Esophagus | + + | 2 |
__________________________________________________________________________|____________|
Gallbladder | + + | 2 |
__________________________________________________________________________|____________|
Intestine Large, Colon | + + | 2 |
__________________________________________________________________________|____________|
Intestine Large, Rectum | + + | 2 |
__________________________________________________________________________|____________|
Intestine Large, Cecum | + + | 2 |
__________________________________________________________________________|____________|
Intestine Small, Duodenum | + + | 2 |
__________________________________________________________________________|____________|
Intestine Small, Jejunum | + + | 2 |
__________________________________________________________________________|____________|
Intestine Small, Ileum | + + | 2 |
__________________________________________________________________________|____________|
Liver | + + + + + + + | 7 |
Hematopoietic Cell Proliferation | 2 | 1 2.0|
Inflammation, Focal | 2 1 1 | 3 1.3|
Inflammation | 1 | 1 1.0|
Necrosis | 3 | 1 3.0|
__________________________________________________________________________|____________|
Pancreas | + + | 2 |
__________________________________________________________________________|____________|
Salivary Glands | + + | 2 |
__________________________________________________________________________|____________|
Stomach, Forestomach | + + + | 3 |
__________________________________________________________________________|____________|
Stomach, Glandular | + + | 2 |
__________________________________________________________________________|____________|
Tooth | + + M + + | 4 |
_____________________________________________________________________________________________________________________| |
CARDIOVASCULAR SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Blood Vessel | + + | 2 |
__________________________________________________________________________|____________|
Heart | + + | 2 |
_____________________________________________________________________________________________________________________| |
ENDOCRINE SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Adrenal Cortex | + + + | 3 |
__________________________________________________________________________|____________|
Adrenal Medulla | + + | 2 |
__________________________________________________________________________|____________|
Islets, Pancreatic | + + | 2 |
__________________________________________________________________________|____________|
Parathyroid Gland | M M | |
__________________________________________________________________________|____________|
Pituitary Gland | + M | 1 |
__________________________________________________________________________|____________|
Thyroid Gland | + + | 2 |
_____________________________________________________________________________________________________________________| |
GENERAL BODY SYSTEM | | |
| | |
None | | |
_____________________________________________________________________________________________________________________| |
GENITAL SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Clitoral Gland | + M | 1 |
__________________________________________________________________________|____________|
Ovary | + + | 2 |
__________________________________________________________________________|____________|
Uterus | + + | 2 |
_____________________________________________________________________________________________________________________| |
HEMATOPOIETIC SYSTEM | | |
__________________________________________________________________________________________________________________________________
* : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade
+ : Tissue examined microscopically M : Missing tissue 1-4 : Lesion qualified as:
X : Lesion present but not qualified A : Autolysis precludes examination 1) Minimal 3) Moderate
I : Insufficient tissue BLANK : Not examined 2) Mild 4) Marked
Page 7
NTP Experiment-Test: 93020-05 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: 150-DAY DIISOPROPYLCARBODIIMIDE Date: 08/19/97
Route: SKIN APPLICATION Time: 14:05:56
__________________________________________________________________________________________________________________________________
| 1| 1| 1| 0| 1| 1| 1| 1| 1| 1| | |
DAY ON TEST | 4| 4| 3| 9| 4| 4| 4| 4| 4| 4| | |
| 1| 1| 3| 9| 1| 1| 1| 1| 1| 1| | T (*) |
_____________________________________________________________________________________________________________________| |
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | O |
TG.AC HETEROZYGOUS TRANSGENIC FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | T |
ANIMAL ID | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | A |
8.75 | 2| 2| 2| 2| 2| 2| 2| 2| 2| 3| | L |
MG/KG | 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| | |
__________________________________________________________________________________________________________________________________
HEMATOPOIETIC SYSTEM - cont | | |
| | |
| | |
__________________________________________________________________________|____________|
Bone Marrow | + + | 2 |
Myeloid Cell, Hyperplasia | 2 | 1 2.0|
__________________________________________________________________________|____________|
Lymph Node | + | 1 |
Infiltration Cellular, Plasma Cell | 3 | 1 3.0|
Infiltration Cellular, Histiocyte | 2 | 1 2.0|
__________________________________________________________________________|____________|
Lymph Node, Mandibular | + + | 2 |
Infiltration Cellular, Plasma Cell | 2 | 1 2.0|
__________________________________________________________________________|____________|
Lymph Node, Mesenteric | + + | 2 |
Infiltration Cellular, Histiocyte | 2 | 1 2.0|
Inflammation, Focal | 3 | 1 3.0|
__________________________________________________________________________|____________|
Spleen | + + + | 3 |
Hematopoietic Cell Proliferation | 3 3 | 2 3.0|
__________________________________________________________________________|____________|
Thymus | + + | 2 |
Atrophy | 4 | 1 4.0|
Thymocyte, Necrosis | 2 | 1 2.0|
_____________________________________________________________________________________________________________________| |
INTEGUMENTARY SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Mammary Gland | + + | 2 |
__________________________________________________________________________|____________|
Skin | + + + + | 4 |
Dermis, Atrophy | 2 | 1 2.0|
Dermis, Skin, Site of Application, | | |
Inflammation | 3 | 1 3.0|
Epidermis, Hyperplasia | 2 | 1 2.0|
Epidermis, Skin, Site of Application,| | |
Hyperplasia | 2 | 1 2.0|
Epidermis, Skin, Site of Application,| | |
Inflammation | 2 1 | 2 1.5|
Skin, Site of Application, Ulcer, | | |
Chronic Active | 3 | 1 3.0|
_____________________________________________________________________________________________________________________| |
MUSCULOSKELETAL SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Bone | + + | 2 |
_____________________________________________________________________________________________________________________| |
NERVOUS SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Brain | + + | 2 |
_____________________________________________________________________________________________________________________| |
RESPIRATORY SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Lung | + + | 2 |
__________________________________________________________________________________________________________________________________
* : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade
+ : Tissue examined microscopically M : Missing tissue 1-4 : Lesion qualified as:
X : Lesion present but not qualified A : Autolysis precludes examination 1) Minimal 3) Moderate
I : Insufficient tissue BLANK : Not examined 2) Mild 4) Marked
Page 8
NTP Experiment-Test: 93020-05 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: 150-DAY DIISOPROPYLCARBODIIMIDE Date: 08/19/97
Route: SKIN APPLICATION Time: 14:05:56
__________________________________________________________________________________________________________________________________
| 1| 1| 1| 0| 1| 1| 1| 1| 1| 1| | |
DAY ON TEST | 4| 4| 3| 9| 4| 4| 4| 4| 4| 4| | |
| 1| 1| 3| 9| 1| 1| 1| 1| 1| 1| | T (*) |
_____________________________________________________________________________________________________________________| |
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | O |
TG.AC HETEROZYGOUS TRANSGENIC FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | T |
ANIMAL ID | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | A |
8.75 | 2| 2| 2| 2| 2| 2| 2| 2| 2| 3| | L |
MG/KG | 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| | |
__________________________________________________________________________________________________________________________________
RESPIRATORY SYSTEM - cont | | |
| | |
Inflammation, Focal | 2 | 1 2.0|
__________________________________________________________________________|____________|
Nose | + M | 1 |
__________________________________________________________________________|____________|
Trachea | + + | 2 |
_____________________________________________________________________________________________________________________| |
SPECIAL SENSES SYSTEM | | |
| | |
None | | |
_____________________________________________________________________________________________________________________| |
URINARY SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Kidney | + + | 2 |
__________________________________________________________________________|____________|
Urinary Bladder | + + | 2 |
__________________________________________________________________________________________________________________________________
* : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade
+ : Tissue examined microscopically M : Missing tissue 1-4 : Lesion qualified as:
X : Lesion present but not qualified A : Autolysis precludes examination 1) Minimal 3) Moderate
I : Insufficient tissue BLANK : Not examined 2) Mild 4) Marked
Page 9
NTP Experiment-Test: 93020-05 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: 150-DAY DIISOPROPYLCARBODIIMIDE Date: 08/19/97
Route: SKIN APPLICATION Time: 14:05:56
__________________________________________________________________________________________________________________________________
| 1| 1| 1| 1| 0| 1| 1| 1| 1| 1| | |
DAY ON TEST | 4| 4| 4| 4| 8| 4| 4| 4| 4| 0| | |
| 1| 1| 1| 1| 2| 1| 1| 1| 1| 8| | T (*) |
_____________________________________________________________________________________________________________________| |
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | O |
TG.AC HETEROZYGOUS TRANSGENIC FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | T |
ANIMAL ID | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | A |
17.5 | 3| 3| 3| 3| 3| 3| 3| 3| 3| 4| | L |
MG/KG | 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| | |
__________________________________________________________________________________________________________________________________
ALIMENTARY SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Esophagus | + + | 2 |
__________________________________________________________________________|____________|
Gallbladder | A + | 1 |
__________________________________________________________________________|____________|
Intestine Large, Colon | A + | 1 |
__________________________________________________________________________|____________|
Intestine Large, Rectum | A + | 1 |
__________________________________________________________________________|____________|
Intestine Large, Cecum | A + | 1 |
__________________________________________________________________________|____________|
Intestine Small, Duodenum | A + | 1 |
__________________________________________________________________________|____________|
Intestine Small, Jejunum | A + | 1 |
__________________________________________________________________________|____________|
Intestine Small, Ileum | A + | 1 |
__________________________________________________________________________|____________|
Liver | + + A + + + + + | 7 |
Inflammation, Focal | 1 1 1 1 1 1 2 | 7 1.1|
__________________________________________________________________________|____________|
Pancreas | A + | 1 |
__________________________________________________________________________|____________|
Salivary Glands | + + | 2 |
__________________________________________________________________________|____________|
Stomach, Forestomach | + + + | 3 |
__________________________________________________________________________|____________|
Stomach, Glandular | + + | 2 |
__________________________________________________________________________|____________|
Tooth | + + + + + + | 6 |
_____________________________________________________________________________________________________________________| |
CARDIOVASCULAR SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Blood Vessel | + + | 2 |
__________________________________________________________________________|____________|
Heart | + + | 2 |
_____________________________________________________________________________________________________________________| |
ENDOCRINE SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Adrenal Cortex | + + + | 3 |
__________________________________________________________________________|____________|
Adrenal Medulla | + + | 2 |
__________________________________________________________________________|____________|
Islets, Pancreatic | A + | 1 |
__________________________________________________________________________|____________|
Parathyroid Gland | + M | 1 |
__________________________________________________________________________|____________|
Pituitary Gland | I + | 1 |
__________________________________________________________________________|____________|
Thyroid Gland | + + | 2 |
_____________________________________________________________________________________________________________________| |
GENERAL BODY SYSTEM | | |
| | |
None | | |
_____________________________________________________________________________________________________________________| |
GENITAL SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Clitoral Gland | M + | 1 |
Atrophy | 2 | 1 2.0|
__________________________________________________________________________|____________|
Ovary | + + | 2 |
__________________________________________________________________________|____________|
Uterus | + + | 2 |
_____________________________________________________________________________________________________________________| |
HEMATOPOIETIC SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Bone Marrow | + + | 2 |
__________________________________________________________________________________________________________________________________
* : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade
+ : Tissue examined microscopically M : Missing tissue 1-4 : Lesion qualified as:
X : Lesion present but not qualified A : Autolysis precludes examination 1) Minimal 3) Moderate
I : Insufficient tissue BLANK : Not examined 2) Mild 4) Marked
Page 10
NTP Experiment-Test: 93020-05 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: 150-DAY DIISOPROPYLCARBODIIMIDE Date: 08/19/97
Route: SKIN APPLICATION Time: 14:05:56
__________________________________________________________________________________________________________________________________
| 1| 1| 1| 1| 0| 1| 1| 1| 1| 1| | |
DAY ON TEST | 4| 4| 4| 4| 8| 4| 4| 4| 4| 0| | |
| 1| 1| 1| 1| 2| 1| 1| 1| 1| 8| | T (*) |
_____________________________________________________________________________________________________________________| |
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | O |
TG.AC HETEROZYGOUS TRANSGENIC FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | T |
ANIMAL ID | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | A |
17.5 | 3| 3| 3| 3| 3| 3| 3| 3| 3| 4| | L |
MG/KG | 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| | |
__________________________________________________________________________________________________________________________________
HEMATOPOIETIC SYSTEM - cont | | |
| | |
__________________________________________________________________________|____________|
Lymph Node | + | 1 |
Mediastinal, Infiltration Cellular, | | |
Histiocyte | 3 | 1 3.0|
__________________________________________________________________________|____________|
Lymph Node, Mandibular | + M | 1 |
Infiltration Cellular, Plasma Cell | 2 | 1 2.0|
__________________________________________________________________________|____________|
Lymph Node, Mesenteric | A + | 1 |
__________________________________________________________________________|____________|
Spleen | + + A + | 3 |
Fibrosis | 2 | 1 2.0|
Hematopoietic Cell Proliferation | 3 | 1 3.0|
__________________________________________________________________________|____________|
Thymus | M M | |
_____________________________________________________________________________________________________________________| |
INTEGUMENTARY SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Mammary Gland | + + | 2 |
__________________________________________________________________________|____________|
Skin | + + + + | 4 |
_____________________________________________________________________________________________________________________| |
MUSCULOSKELETAL SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Bone | + + | 2 |
_____________________________________________________________________________________________________________________| |
NERVOUS SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Brain | + + | 2 |
_____________________________________________________________________________________________________________________| |
RESPIRATORY SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Lung | + + + | 3 |
Inflammation, Chronic Active, Focal | 3 | 1 3.0|
__________________________________________________________________________|____________|
Nose | + + | 2 |
__________________________________________________________________________|____________|
Trachea | + + | 2 |
_____________________________________________________________________________________________________________________| |
SPECIAL SENSES SYSTEM | | |
| | |
None | | |
_____________________________________________________________________________________________________________________| |
URINARY SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Kidney | + + | 2 |
__________________________________________________________________________|____________|
Urinary Bladder | + + | 2 |
__________________________________________________________________________________________________________________________________
* : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade
+ : Tissue examined microscopically M : Missing tissue 1-4 : Lesion qualified as:
X : Lesion present but not qualified A : Autolysis precludes examination 1) Minimal 3) Moderate
I : Insufficient tissue BLANK : Not examined 2) Mild 4) Marked
Page 11
NTP Experiment-Test: 93020-05 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: 150-DAY DIISOPROPYLCARBODIIMIDE Date: 08/19/97
Route: SKIN APPLICATION Time: 14:05:56
__________________________________________________________________________________________________________________________________
| 1| 1| 0| 0| 1| 0| 1| 1| 1| 0| | |
DAY ON TEST | 4| 4| 4| 4| 4| 6| 4| 4| 4| 5| | |
| 1| 1| 8| 5| 1| 6| 1| 1| 1| 4| | T (*) |
_____________________________________________________________________________________________________________________| |
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | O |
TG.AC HETEROZYGOUS TRANSGENIC FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | T |
ANIMAL ID | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | A |
35 | 4| 4| 4| 4| 4| 4| 4| 4| 4| 5| | L |
MG/KG | 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| | |
__________________________________________________________________________________________________________________________________
ALIMENTARY SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Esophagus | + + M + | 3 |
__________________________________________________________________________|____________|
Gallbladder | + M + M | 2 |
__________________________________________________________________________|____________|
Intestine Large, Colon | + A + A | 2 |
__________________________________________________________________________|____________|
Intestine Large, Rectum | + A + A | 2 |
__________________________________________________________________________|____________|
Intestine Large, Cecum | + A + A | 2 |
__________________________________________________________________________|____________|
Intestine Small, Duodenum | + A + A | 2 |
__________________________________________________________________________|____________|
Intestine Small, Jejunum | + A + A | 2 |
__________________________________________________________________________|____________|
Intestine Small, Ileum | + A + A | 2 |
__________________________________________________________________________|____________|
Liver | + + + + + + | 6 |
Inflammation, Focal | 2 2 | 2 2.0|
__________________________________________________________________________|____________|
Pancreas | + + + + | 4 |
__________________________________________________________________________|____________|
Salivary Glands | + + + + | 4 |
__________________________________________________________________________|____________|
Stomach, Forestomach | + A + A | 2 |
__________________________________________________________________________|____________|
Stomach, Glandular | + A + A | 2 |
__________________________________________________________________________|____________|
Tongue | + | 1 |
Epithelium, Hyperkeratosis | 2 | 1 2.0|
__________________________________________________________________________|____________|
Tooth | + + + | 3 |
Hyperplasia, Odontogenic | 2 | 1 2.0|
_____________________________________________________________________________________________________________________| |
CARDIOVASCULAR SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Blood Vessel | + + + + | 4 |
__________________________________________________________________________|____________|
Heart | + + + + | 4 |
_____________________________________________________________________________________________________________________| |
ENDOCRINE SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Adrenal Cortex | + + + + + | 5 |
__________________________________________________________________________|____________|
Adrenal Medulla | + + + + | 4 |
__________________________________________________________________________|____________|
Islets, Pancreatic | + + + + | 4 |
__________________________________________________________________________|____________|
Parathyroid Gland | M M M M | |
__________________________________________________________________________|____________|
Pituitary Gland | + M + M | 2 |
__________________________________________________________________________|____________|
Thyroid Gland | + + + + | 4 |
_____________________________________________________________________________________________________________________| |
GENERAL BODY SYSTEM | | |
| | |
None | | |
_____________________________________________________________________________________________________________________| |
GENITAL SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Clitoral Gland | + M + M | 2 |
__________________________________________________________________________|____________|
Ovary | + + + + | 4 |
__________________________________________________________________________|____________|
Uterus | + + + + | 4 |
Bilateral, Hydrometra | 1 | 1 1.0|
__________________________________________________________________________________________________________________________________
* : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade
+ : Tissue examined microscopically M : Missing tissue 1-4 : Lesion qualified as:
X : Lesion present but not qualified A : Autolysis precludes examination 1) Minimal 3) Moderate
I : Insufficient tissue BLANK : Not examined 2) Mild 4) Marked
Page 12
NTP Experiment-Test: 93020-05 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: 150-DAY DIISOPROPYLCARBODIIMIDE Date: 08/19/97
Route: SKIN APPLICATION Time: 14:05:56
__________________________________________________________________________________________________________________________________
| 1| 1| 0| 0| 1| 0| 1| 1| 1| 0| | |
DAY ON TEST | 4| 4| 4| 4| 4| 6| 4| 4| 4| 5| | |
| 1| 1| 8| 5| 1| 6| 1| 1| 1| 4| | T (*) |
_____________________________________________________________________________________________________________________| |
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | O |
TG.AC HETEROZYGOUS TRANSGENIC FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | T |
ANIMAL ID | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | A |
35 | 4| 4| 4| 4| 4| 4| 4| 4| 4| 5| | L |
MG/KG | 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| | |
__________________________________________________________________________________________________________________________________
GENITAL SYSTEM - cont | | |
| | |
_____________________________________________________________________________________________________________________| |
HEMATOPOIETIC SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Bone Marrow | + + + + | 4 |
__________________________________________________________________________|____________|
Lymph Node, Mandibular | + + + + | 4 |
__________________________________________________________________________|____________|
Lymph Node, Mesenteric | + + + + A | 4 |
Inflammation, Focal | 2 | 1 2.0|
__________________________________________________________________________|____________|
Spleen | + + A + + + + | 6 |
Hematopoietic Cell Proliferation | 3 2 2 3 2 | 5 2.4|
Lymphoid Follicle, Necrosis | 3 | 1 3.0|
__________________________________________________________________________|____________|
Thymus | + + + A | 3 |
Thymocyte, Necrosis | 4 | 1 4.0|
_____________________________________________________________________________________________________________________| |
INTEGUMENTARY SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Mammary Gland | M + + M | 2 |
__________________________________________________________________________|____________|
Skin | + + + + | 4 |
Dermis, Skin, Site of Application, | | |
Inflammation | 2 | 1 2.0|
Epidermis, Skin, Site of Application,| | |
Hyperplasia | 2 | 1 2.0|
_____________________________________________________________________________________________________________________| |
MUSCULOSKELETAL SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Bone | + + + + | 4 |
_____________________________________________________________________________________________________________________| |
NERVOUS SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Brain | + + + + | 4 |
_____________________________________________________________________________________________________________________| |
RESPIRATORY SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Lung | + + + + | 4 |
__________________________________________________________________________|____________|
Nose | + + + + | 4 |
__________________________________________________________________________|____________|
Trachea | + + + + | 4 |
_____________________________________________________________________________________________________________________| |
SPECIAL SENSES SYSTEM | | |
| | |
None | | |
_____________________________________________________________________________________________________________________| |
URINARY SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Kidney | + + + + | 4 |
__________________________________________________________________________|____________|
Urinary Bladder | + + + + | 4 |
__________________________________________________________________________________________________________________________________
* : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade
+ : Tissue examined microscopically M : Missing tissue 1-4 : Lesion qualified as:
X : Lesion present but not qualified A : Autolysis precludes examination 1) Minimal 3) Moderate
I : Insufficient tissue BLANK : Not examined 2) Mild 4) Marked
Page 13
NTP Experiment-Test: 93020-05 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: 150-DAY DIISOPROPYLCARBODIIMIDE Date: 08/19/97
Route: SKIN APPLICATION Time: 14:05:56
__________________________________________________________________________________________________________________________________
| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| | |
DAY ON TEST | 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| | |
| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| | T (*) |
_____________________________________________________________________________________________________________________| |
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | O |
TG.AC HETEROZYGOUS TRANSGENIC FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | T |
ANIMAL ID | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | A |
70 | 5| 5| 5| 5| 5| 5| 5| 5| 5| 6| | L |
MG/KG | 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| | |
__________________________________________________________________________________________________________________________________
ALIMENTARY SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Esophagus | + + + + + + + + + + | 10 |
__________________________________________________________________________|____________|
Gallbladder | + + + + + I + + + + | 9 |
__________________________________________________________________________|____________|
Intestine Large, Colon | + + + + + + + + + + | 10 |
__________________________________________________________________________|____________|
Intestine Large, Rectum | + + + + + + + + + + | 10 |
__________________________________________________________________________|____________|
Intestine Large, Cecum | + + + + + + + + + + | 10 |
__________________________________________________________________________|____________|
Intestine Small, Duodenum | + + + + + + + + + + | 10 |
__________________________________________________________________________|____________|
Intestine Small, Jejunum | + + + + + + + + + + | 10 |
__________________________________________________________________________|____________|
Intestine Small, Ileum | + + + + + + + + + + | 10 |
__________________________________________________________________________|____________|
Liver | + + + + + + + + + + | 10 |
Hematopoietic Cell Proliferation | 1 | 1 1.0|
Inflammation, Focal | 2 2 1 1 2 2 2 2 | 8 1.8|
__________________________________________________________________________|____________|
Pancreas | + + + + + + + + + + | 10 |
__________________________________________________________________________|____________|
Salivary Glands | + + + + + + + + + + | 10 |
__________________________________________________________________________|____________|
Stomach, Forestomach | + + + + + + + + + + | 10 |
__________________________________________________________________________|____________|
Stomach, Glandular | + + + + + + + + + + | 10 |
Inflammation | 1 | 1 1.0|
__________________________________________________________________________|____________|
Tooth | + + + + + + + | 7 |
Hyperplasia, Odontogenic | 3 | 1 3.0|
_____________________________________________________________________________________________________________________| |
CARDIOVASCULAR SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Blood Vessel | + + + + + + + + + + | 10 |
__________________________________________________________________________|____________|
Heart | + + + + + + + + + + | 10 |
_____________________________________________________________________________________________________________________| |
ENDOCRINE SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Adrenal Cortex | + + + + + + + + + + | 10 |
__________________________________________________________________________|____________|
Adrenal Medulla | + + + + + + + + + + | 10 |
__________________________________________________________________________|____________|
Islets, Pancreatic | + + + + + + + + + + | 10 |
__________________________________________________________________________|____________|
Parathyroid Gland | M M + M + + M M + + | 5 |
__________________________________________________________________________|____________|
Pituitary Gland | + + M M + + + + M M | 6 |
__________________________________________________________________________|____________|
Thyroid Gland | + + + + + + + M + + | 9 |
_____________________________________________________________________________________________________________________| |
GENERAL BODY SYSTEM | | |
| | |
None | | |
_____________________________________________________________________________________________________________________| |
GENITAL SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Clitoral Gland | + + + + + + + M + M | 8 |
__________________________________________________________________________|____________|
Ovary | + + + + + + + + + + | 10 |
__________________________________________________________________________|____________|
Uterus | + + + + + + + + + + | 10 |
Hydrometra | 2 2 | 2 2.0|
__________________________________________________________________________________________________________________________________
* : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade
+ : Tissue examined microscopically M : Missing tissue 1-4 : Lesion qualified as:
X : Lesion present but not qualified A : Autolysis precludes examination 1) Minimal 3) Moderate
I : Insufficient tissue BLANK : Not examined 2) Mild 4) Marked
Page 14
NTP Experiment-Test: 93020-05 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: 150-DAY DIISOPROPYLCARBODIIMIDE Date: 08/19/97
Route: SKIN APPLICATION Time: 14:05:56
__________________________________________________________________________________________________________________________________
| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| | |
DAY ON TEST | 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| | |
| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| | T (*) |
_____________________________________________________________________________________________________________________| |
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | O |
TG.AC HETEROZYGOUS TRANSGENIC FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | T |
ANIMAL ID | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | A |
70 | 5| 5| 5| 5| 5| 5| 5| 5| 5| 6| | L |
MG/KG | 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| | |
__________________________________________________________________________________________________________________________________
GENITAL SYSTEM - cont | | |
| | |
Bilateral, Hydrometra | 2 | 1 2.0|
_____________________________________________________________________________________________________________________| |
HEMATOPOIETIC SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Bone Marrow | + + + + + + + + + + | 10 |
__________________________________________________________________________|____________|
Lymph Node, Mandibular | + + + + + + + + + + | 10 |
Infiltration Cellular, | | |
Polymorphonuclear | 2 | 1 2.0|
__________________________________________________________________________|____________|
Lymph Node, Mesenteric | + + + + + + + + + + | 10 |
Inflammation | 2 | 1 2.0|
__________________________________________________________________________|____________|
Spleen | + + + + + + + + + + | 10 |
Hematopoietic Cell Proliferation | 2 3 3 3 2 2 2 2 1 | 9 2.2|
__________________________________________________________________________|____________|
Thymus | + + + + + + + + + + | 10 |
_____________________________________________________________________________________________________________________| |
INTEGUMENTARY SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Mammary Gland | + + + + + + + + + + | 10 |
__________________________________________________________________________|____________|
Skin | + + + + + + + + + + | 10 |
Dermis, Skin, Site of Application, | | |
Inflammation | 1 | 1 1.0|
Epidermis, Skin, Site of Application,| | |
Inflammation, Chronic Active | 2 | 1 2.0|
_____________________________________________________________________________________________________________________| |
MUSCULOSKELETAL SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Bone | + + + + + + + + + + | 10 |
_____________________________________________________________________________________________________________________| |
NERVOUS SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Brain | + + + + + + + + + + | 10 |
_____________________________________________________________________________________________________________________| |
RESPIRATORY SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Lung | + + + + + + + + + + | 10 |
Inflammation, Chronic Active, Focal | 2 | 1 2.0|
__________________________________________________________________________|____________|
Nose | + + + + + + + + + + | 10 |
Inflammation | 3 3 | 2 3.0|
__________________________________________________________________________|____________|
Trachea | + + + + + + + + + + | 10 |
_____________________________________________________________________________________________________________________| |
SPECIAL SENSES SYSTEM | | |
| | |
None | | |
_____________________________________________________________________________________________________________________| |
URINARY SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Kidney | + + + + + + + + + + | 10 |
__________________________________________________________________________________________________________________________________
* : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade
+ : Tissue examined microscopically M : Missing tissue 1-4 : Lesion qualified as:
X : Lesion present but not qualified A : Autolysis precludes examination 1) Minimal 3) Moderate
I : Insufficient tissue BLANK : Not examined 2) Mild 4) Marked
Page 15
NTP Experiment-Test: 93020-05 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: 150-DAY DIISOPROPYLCARBODIIMIDE Date: 08/19/97
Route: SKIN APPLICATION Time: 14:05:56
__________________________________________________________________________________________________________________________________
| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| | |
DAY ON TEST | 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| | |
| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| | T (*) |
_____________________________________________________________________________________________________________________| |
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | O |
TG.AC HETEROZYGOUS TRANSGENIC FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | T |
ANIMAL ID | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | A |
70 | 5| 5| 5| 5| 5| 5| 5| 5| 5| 6| | L |
MG/KG | 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| | |
__________________________________________________________________________________________________________________________________
URINARY SYSTEM - cont | | |
| | |
__________________________________________________________________________|____________|
Urinary Bladder | + + + + + + + + + + | 10 |
__________________________________________________________________________________________________________________________________
* : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade
+ : Tissue examined microscopically M : Missing tissue 1-4 : Lesion qualified as:
X : Lesion present but not qualified A : Autolysis precludes examination 1) Minimal 3) Moderate
I : Insufficient tissue BLANK : Not examined 2) Mild 4) Marked
Page 16
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---------- END OF REPORT ----------
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