TDMS Study 93020-05 Pathology Tables
NTP Experiment-Test: 93020-05 NEOPLASMS BY INDIVIDUAL ANIMAL (SYSTEMIC LESIONS ABRIDGED) Report: PEIRPT17
Study Type: 150-DAY DIISOPROPYLCARBODIIMIDE Date: 03/28/05
Route: SKIN APPLICATION Time: 08:45:30
Facility: BIORELIANCE
Chemical CAS #: 693-13-0
Lock Date: 03/26/96
Cage Range: All
Reasons For Removal: All
Removal Date Range: All
Treatment Groups: Include All
Note: Animals arranged according to days on test
Page 1
NTP Experiment-Test: 93020-05 NEOPLASMS BY INDIVIDUAL ANIMAL (SYSTEMIC LESIONS ABRIDGED) Report: PEIRPT17
Study Type: 150-DAY DIISOPROPYLCARBODIIMIDE Date: 03/28/05
Route: SKIN APPLICATION Time: 08:45:30
__________________________________________________________________________________________________________________________________
| 0| 1| 1| 1| 1| 1| 1| 1| 1| 1| | |
DAY ON TEST | 9| 1| 4| 4| 4| 4| 4| 4| 4| 4| | |
| 7| 1| 1| 1| 1| 1| 1| 1| 1| 1| | |
__________________________________________|__________________________________________________________________________| T (*) |
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | O |
TGAC (FVB/N) HEMIZYGOUS FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | T |
ANIMAL ID | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | A |
0 | 0| 0| 0| 0| 0| 0| 0| 0| 0| 1| | L |
MG/KG | 3| 6| 1| 2| 4| 5| 7| 8| 9| 0| | |
_____________________________________________________________________________________________________________________|____________|
ALIMENTARY SYSTEM | | |
|__________________________________________________________________________|____________|
Esophagus | + + + + + + + + + + | 10 |
|__________________________________________________________________________|____________|
Gallbladder | A + + M + M + M + + | 6 |
|__________________________________________________________________________|____________|
Intestine Large, Colon | A + + + + + + + + + | 9 |
|__________________________________________________________________________|____________|
Intestine Large, Rectum | A + + + + + + + + + | 9 |
|__________________________________________________________________________|____________|
Intestine Large, Cecum | A + + + + + + + + + | 9 |
|__________________________________________________________________________|____________|
Intestine Small, Duodenum | A + + + + + + + + + | 9 |
|__________________________________________________________________________|____________|
Intestine Small, Jejunum | A + + + + + + + + + | 9 |
Carcinoma | X | 1 |
|__________________________________________________________________________|____________|
Intestine Small, Ileum | A + + + + + + + + + | 9 |
|__________________________________________________________________________|____________|
Liver | + + + + + + + + + + | 10 |
|__________________________________________________________________________|____________|
Pancreas | A + + + + + + + + + | 9 |
|__________________________________________________________________________|____________|
Salivary Glands | + + + + + + + + + + | 10 |
|__________________________________________________________________________|____________|
Stomach, Forestomach | + + + + + + + + + + | 10 |
|__________________________________________________________________________|____________|
Stomach, Glandular | + + + + + + + + + + | 10 |
|__________________________________________________________________________|____________|
Tooth | + + + | 3 |
Odontoma | X X X | 3 |
_____________________________________________________________________________________________________________________| |
CARDIOVASCULAR SYSTEM | | |
|__________________________________________________________________________|____________|
_____________________________________________________________________________________________________________________|____________|
* : Total animals with tissue examined microscopically; total animals with tumor
+ : Tissue examined microscopically M : Missing tissue
X : Lesion present A : Autolysis precludes evaluation
I : Insufficient tissue BLANK : Not examined microscopically
Page 2
NTP Experiment-Test: 93020-05 NEOPLASMS BY INDIVIDUAL ANIMAL (SYSTEMIC LESIONS ABRIDGED) Report: PEIRPT17
Study Type: 150-DAY DIISOPROPYLCARBODIIMIDE Date: 03/28/05
Route: SKIN APPLICATION Time: 08:45:30
__________________________________________________________________________________________________________________________________
| 0| 1| 1| 1| 1| 1| 1| 1| 1| 1| | |
DAY ON TEST | 9| 1| 4| 4| 4| 4| 4| 4| 4| 4| | |
| 7| 1| 1| 1| 1| 1| 1| 1| 1| 1| | |
__________________________________________|__________________________________________________________________________| T (*) |
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | O |
TGAC (FVB/N) HEMIZYGOUS FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | T |
ANIMAL ID | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | A |
0 | 0| 0| 0| 0| 0| 0| 0| 0| 0| 1| | L |
MG/KG | 3| 6| 1| 2| 4| 5| 7| 8| 9| 0| | |
_____________________________________________________________________________________________________________________|____________|
CARDIOVASCULAR SYSTEM - cont | | |
| | |
Blood Vessel | + + + + + + + + + + | 10 |
|__________________________________________________________________________|____________|
Heart | + + + + + + + + + + | 10 |
_____________________________________________________________________________________________________________________| |
ENDOCRINE SYSTEM | | |
|__________________________________________________________________________|____________|
Adrenal Cortex | + + + + + + + + + + | 10 |
|__________________________________________________________________________|____________|
Adrenal Medulla | + + + + + + + + + + | 10 |
|__________________________________________________________________________|____________|
Islets, Pancreatic | + + + + + + + + + + | 10 |
|__________________________________________________________________________|____________|
Parathyroid Gland | M M + + + M M M M + | 4 |
|__________________________________________________________________________|____________|
Pituitary Gland | I M + + + + + + + + | 8 |
|__________________________________________________________________________|____________|
Thyroid Gland | + + + + + + + + + + | 10 |
_____________________________________________________________________________________________________________________| |
GENERAL BODY SYSTEM | | |
None | | |
_____________________________________________________________________________________________________________________| |
GENITAL SYSTEM | | |
|__________________________________________________________________________|____________|
Clitoral Gland | + + M + M + M + + + | 7 |
|__________________________________________________________________________|____________|
Ovary | + + + + + + + + + + | 10 |
|__________________________________________________________________________|____________|
Uterus | + + + + + + + + + + | 10 |
_____________________________________________________________________________________________________________________| |
HEMATOPOIETIC SYSTEM | | |
|__________________________________________________________________________|____________|
Bone Marrow | + + + + + + + + + + | 10 |
_____________________________________________________________________________________________________________________|____________|
* : Total animals with tissue examined microscopically; total animals with tumor
+ : Tissue examined microscopically M : Missing tissue
X : Lesion present A : Autolysis precludes evaluation
I : Insufficient tissue BLANK : Not examined microscopically
Page 3
NTP Experiment-Test: 93020-05 NEOPLASMS BY INDIVIDUAL ANIMAL (SYSTEMIC LESIONS ABRIDGED) Report: PEIRPT17
Study Type: 150-DAY DIISOPROPYLCARBODIIMIDE Date: 03/28/05
Route: SKIN APPLICATION Time: 08:45:30
__________________________________________________________________________________________________________________________________
| 0| 1| 1| 1| 1| 1| 1| 1| 1| 1| | |
DAY ON TEST | 9| 1| 4| 4| 4| 4| 4| 4| 4| 4| | |
| 7| 1| 1| 1| 1| 1| 1| 1| 1| 1| | |
__________________________________________|__________________________________________________________________________| T (*) |
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | O |
TGAC (FVB/N) HEMIZYGOUS FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | T |
ANIMAL ID | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | A |
0 | 0| 0| 0| 0| 0| 0| 0| 0| 0| 1| | L |
MG/KG | 3| 6| 1| 2| 4| 5| 7| 8| 9| 0| | |
_____________________________________________________________________________________________________________________|____________|
HEMATOPOIETIC SYSTEM - cont | | |
| | |
|__________________________________________________________________________|____________|
Lymph Node, Mandibular | + + + + + + + + + + | 10 |
|__________________________________________________________________________|____________|
Lymph Node, Mesenteric | + + + + + + M + + + | 9 |
|__________________________________________________________________________|____________|
Spleen | A + + + + + + + + + | 9 |
|__________________________________________________________________________|____________|
Thymus | + M + + + + + + + + | 9 |
_____________________________________________________________________________________________________________________| |
INTEGUMENTARY SYSTEM | | |
|__________________________________________________________________________|____________|
Mammary Gland | M + + + + + + + + + | 9 |
|__________________________________________________________________________|____________|
Skin | + + + + + + + + + + | 10 |
Squamous Cell Papilloma, Multiple | X | 1 |
Skin, Site of Application, Squamous | | |
Cell Papilloma, Multiple | X | 1 |
_____________________________________________________________________________________________________________________| |
MUSCULOSKELETAL SYSTEM | | |
|__________________________________________________________________________|____________|
Bone | + + + + + + + + + + | 10 |
_____________________________________________________________________________________________________________________| |
NERVOUS SYSTEM | | |
|__________________________________________________________________________|____________|
Brain | + + + + + + + + + + | 10 |
_____________________________________________________________________________________________________________________| |
RESPIRATORY SYSTEM | | |
|__________________________________________________________________________|____________|
Lung | + + + + + + + + + + | 10 |
|__________________________________________________________________________|____________|
Nose | + + + + + + + + + + | 10 |
Respiratory Epithelium, Adenoma | X | 1 |
_____________________________________________________________________________________________________________________|____________|
* : Total animals with tissue examined microscopically; total animals with tumor
+ : Tissue examined microscopically M : Missing tissue
X : Lesion present A : Autolysis precludes evaluation
I : Insufficient tissue BLANK : Not examined microscopically
Page 4
NTP Experiment-Test: 93020-05 NEOPLASMS BY INDIVIDUAL ANIMAL (SYSTEMIC LESIONS ABRIDGED) Report: PEIRPT17
Study Type: 150-DAY DIISOPROPYLCARBODIIMIDE Date: 03/28/05
Route: SKIN APPLICATION Time: 08:45:30
__________________________________________________________________________________________________________________________________
| 0| 1| 1| 1| 1| 1| 1| 1| 1| 1| | |
DAY ON TEST | 9| 1| 4| 4| 4| 4| 4| 4| 4| 4| | |
| 7| 1| 1| 1| 1| 1| 1| 1| 1| 1| | |
__________________________________________|__________________________________________________________________________| T (*) |
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | O |
TGAC (FVB/N) HEMIZYGOUS FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | T |
ANIMAL ID | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | A |
0 | 0| 0| 0| 0| 0| 0| 0| 0| 0| 1| | L |
MG/KG | 3| 6| 1| 2| 4| 5| 7| 8| 9| 0| | |
_____________________________________________________________________________________________________________________|____________|
RESPIRATORY SYSTEM - cont | | |
| | |
|__________________________________________________________________________|____________|
Trachea | + + + + + + + + + + | 10 |
_____________________________________________________________________________________________________________________| |
SPECIAL SENSES SYSTEM | | |
None | | |
_____________________________________________________________________________________________________________________| |
URINARY SYSTEM | | |
|__________________________________________________________________________|____________|
Kidney | + + + + + + + + + + | 10 |
|__________________________________________________________________________|____________|
Urinary Bladder | + + + + + + + + + + | 10 |
__________________________________________________________________________________________________________________________________
SYSTEMIC LESIONS | | |
__________________________________________________________________________|____________|
Multiple Organs | + + + + + + + + + + | 10 |
Leukemia Erythrocytic | X | 1 |
__________________________________________________________________________________________________________________________________
* : Total animals with tissue examined microscopically; total animals with tumor
+ : Tissue examined microscopically M : Missing tissue
X : Lesion present A : Autolysis precludes evaluation
I : Insufficient tissue BLANK : Not examined microscopically
Page 5
NTP Experiment-Test: 93020-05 NEOPLASMS BY INDIVIDUAL ANIMAL (SYSTEMIC LESIONS ABRIDGED) Report: PEIRPT17
Study Type: 150-DAY DIISOPROPYLCARBODIIMIDE Date: 03/28/05
Route: SKIN APPLICATION Time: 08:45:30
__________________________________________________________________________________________________________________________________
| 0| 1| 1| 1| 1| 1| 1| 1| 1| 1| | |
DAY ON TEST | 9| 3| 4| 4| 4| 4| 4| 4| 4| 4| | |
| 3| 8| 1| 1| 1| 1| 1| 1| 1| 1| | |
__________________________________________|__________________________________________________________________________| T (*) |
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | O |
TGAC (FVB/N) HEMIZYGOUS FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | T |
ANIMAL ID | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | A |
4.38 | 1| 1| 1| 1| 1| 1| 1| 1| 1| 2| | L |
MG/KG | 4| 9| 1| 2| 3| 5| 6| 7| 8| 0| | |
_____________________________________________________________________________________________________________________|____________|
ALIMENTARY SYSTEM | | |
|__________________________________________________________________________|____________|
Esophagus | + + | 2 |
|__________________________________________________________________________|____________|
Gallbladder | + + | 2 |
|__________________________________________________________________________|____________|
Intestine Large, Colon | + + | 2 |
|__________________________________________________________________________|____________|
Intestine Large, Rectum | + + | 2 |
|__________________________________________________________________________|____________|
Intestine Large, Cecum | + + | 2 |
|__________________________________________________________________________|____________|
Intestine Small, Duodenum | + + | 2 |
|__________________________________________________________________________|____________|
Intestine Small, Jejunum | + + | 2 |
|__________________________________________________________________________|____________|
Intestine Small, Ileum | + + | 2 |
|__________________________________________________________________________|____________|
Liver | + + + + + + | 6 |
|__________________________________________________________________________|____________|
Pancreas | + + | 2 |
|__________________________________________________________________________|____________|
Salivary Glands | + + | 2 |
|__________________________________________________________________________|____________|
Stomach, Forestomach | + + | 2 |
|__________________________________________________________________________|____________|
Stomach, Glandular | + + | 2 |
|__________________________________________________________________________|____________|
Tooth | + + + + | 4 |
Odontoma | X X | 2 |
_____________________________________________________________________________________________________________________| |
CARDIOVASCULAR SYSTEM | | |
|__________________________________________________________________________|____________|
Blood Vessel | + + | 2 |
_____________________________________________________________________________________________________________________|____________|
* : Total animals with tissue examined microscopically; total animals with tumor
+ : Tissue examined microscopically M : Missing tissue
X : Lesion present A : Autolysis precludes evaluation
I : Insufficient tissue BLANK : Not examined microscopically
Page 6
NTP Experiment-Test: 93020-05 NEOPLASMS BY INDIVIDUAL ANIMAL (SYSTEMIC LESIONS ABRIDGED) Report: PEIRPT17
Study Type: 150-DAY DIISOPROPYLCARBODIIMIDE Date: 03/28/05
Route: SKIN APPLICATION Time: 08:45:30
__________________________________________________________________________________________________________________________________
| 0| 1| 1| 1| 1| 1| 1| 1| 1| 1| | |
DAY ON TEST | 9| 3| 4| 4| 4| 4| 4| 4| 4| 4| | |
| 3| 8| 1| 1| 1| 1| 1| 1| 1| 1| | |
__________________________________________|__________________________________________________________________________| T (*) |
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | O |
TGAC (FVB/N) HEMIZYGOUS FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | T |
ANIMAL ID | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | A |
4.38 | 1| 1| 1| 1| 1| 1| 1| 1| 1| 2| | L |
MG/KG | 4| 9| 1| 2| 3| 5| 6| 7| 8| 0| | |
_____________________________________________________________________________________________________________________|____________|
CARDIOVASCULAR SYSTEM - cont | | |
| | |
|__________________________________________________________________________|____________|
Heart | + + | 2 |
_____________________________________________________________________________________________________________________| |
ENDOCRINE SYSTEM | | |
|__________________________________________________________________________|____________|
Adrenal Cortex | + + + + | 4 |
|__________________________________________________________________________|____________|
Adrenal Medulla | + + | 2 |
|__________________________________________________________________________|____________|
Islets, Pancreatic | + + | 2 |
|__________________________________________________________________________|____________|
Parathyroid Gland | M M | |
|__________________________________________________________________________|____________|
Pituitary Gland | + + | 2 |
|__________________________________________________________________________|____________|
Thyroid Gland | + + | 2 |
_____________________________________________________________________________________________________________________| |
GENERAL BODY SYSTEM | | |
None | | |
_____________________________________________________________________________________________________________________| |
GENITAL SYSTEM | | |
|__________________________________________________________________________|____________|
Clitoral Gland | + + | 2 |
|__________________________________________________________________________|____________|
Ovary | + + | 2 |
|__________________________________________________________________________|____________|
Uterus | + + | 2 |
_____________________________________________________________________________________________________________________| |
HEMATOPOIETIC SYSTEM | | |
|__________________________________________________________________________|____________|
Bone Marrow | + + | 2 |
|__________________________________________________________________________|____________|
_____________________________________________________________________________________________________________________|____________|
* : Total animals with tissue examined microscopically; total animals with tumor
+ : Tissue examined microscopically M : Missing tissue
X : Lesion present A : Autolysis precludes evaluation
I : Insufficient tissue BLANK : Not examined microscopically
Page 7
NTP Experiment-Test: 93020-05 NEOPLASMS BY INDIVIDUAL ANIMAL (SYSTEMIC LESIONS ABRIDGED) Report: PEIRPT17
Study Type: 150-DAY DIISOPROPYLCARBODIIMIDE Date: 03/28/05
Route: SKIN APPLICATION Time: 08:45:30
__________________________________________________________________________________________________________________________________
| 0| 1| 1| 1| 1| 1| 1| 1| 1| 1| | |
DAY ON TEST | 9| 3| 4| 4| 4| 4| 4| 4| 4| 4| | |
| 3| 8| 1| 1| 1| 1| 1| 1| 1| 1| | |
__________________________________________|__________________________________________________________________________| T (*) |
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | O |
TGAC (FVB/N) HEMIZYGOUS FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | T |
ANIMAL ID | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | A |
4.38 | 1| 1| 1| 1| 1| 1| 1| 1| 1| 2| | L |
MG/KG | 4| 9| 1| 2| 3| 5| 6| 7| 8| 0| | |
_____________________________________________________________________________________________________________________|____________|
HEMATOPOIETIC SYSTEM - cont | | |
| | |
Lymph Node, Mandibular | + + | 2 |
|__________________________________________________________________________|____________|
Lymph Node, Mesenteric | + + | 2 |
|__________________________________________________________________________|____________|
Spleen | + + + + + | 5 |
|__________________________________________________________________________|____________|
Thymus | + + | 2 |
_____________________________________________________________________________________________________________________| |
INTEGUMENTARY SYSTEM | | |
|__________________________________________________________________________|____________|
Mammary Gland | + + | 2 |
|__________________________________________________________________________|____________|
Skin | + + + | 3 |
Squamous Cell Papilloma | X | 1 |
_____________________________________________________________________________________________________________________| |
MUSCULOSKELETAL SYSTEM | | |
|__________________________________________________________________________|____________|
Bone | + + | 2 |
_____________________________________________________________________________________________________________________| |
NERVOUS SYSTEM | | |
|__________________________________________________________________________|____________|
Brain | + + | 2 |
_____________________________________________________________________________________________________________________| |
RESPIRATORY SYSTEM | | |
|__________________________________________________________________________|____________|
Lung | + + | 2 |
|__________________________________________________________________________|____________|
Nose | + + + + + | 5 |
|__________________________________________________________________________|____________|
Trachea | + + | 2 |
_____________________________________________________________________________________________________________________| |
SPECIAL SENSES SYSTEM | | |
None | | |
_____________________________________________________________________________________________________________________|____________|
* : Total animals with tissue examined microscopically; total animals with tumor
+ : Tissue examined microscopically M : Missing tissue
X : Lesion present A : Autolysis precludes evaluation
I : Insufficient tissue BLANK : Not examined microscopically
Page 8
NTP Experiment-Test: 93020-05 NEOPLASMS BY INDIVIDUAL ANIMAL (SYSTEMIC LESIONS ABRIDGED) Report: PEIRPT17
Study Type: 150-DAY DIISOPROPYLCARBODIIMIDE Date: 03/28/05
Route: SKIN APPLICATION Time: 08:45:30
__________________________________________________________________________________________________________________________________
| 0| 1| 1| 1| 1| 1| 1| 1| 1| 1| | |
DAY ON TEST | 9| 3| 4| 4| 4| 4| 4| 4| 4| 4| | |
| 3| 8| 1| 1| 1| 1| 1| 1| 1| 1| | |
__________________________________________|__________________________________________________________________________| T (*) |
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | O |
TGAC (FVB/N) HEMIZYGOUS FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | T |
ANIMAL ID | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | A |
4.38 | 1| 1| 1| 1| 1| 1| 1| 1| 1| 2| | L |
MG/KG | 4| 9| 1| 2| 3| 5| 6| 7| 8| 0| | |
_____________________________________________________________________________________________________________________|____________|
URINARY SYSTEM | | |
|__________________________________________________________________________|____________|
Kidney | + + | 2 |
|__________________________________________________________________________|____________|
Urinary Bladder | + + | 2 |
__________________________________________________________________________________________________________________________________
SYSTEMIC LESIONS | | |
__________________________________________________________________________|____________|
Multiple Organs | + + + + + + + + | 8 |
__________________________________________________________________________________________________________________________________
* : Total animals with tissue examined microscopically; total animals with tumor
+ : Tissue examined microscopically M : Missing tissue
X : Lesion present A : Autolysis precludes evaluation
I : Insufficient tissue BLANK : Not examined microscopically
Page 9
NTP Experiment-Test: 93020-05 NEOPLASMS BY INDIVIDUAL ANIMAL (SYSTEMIC LESIONS ABRIDGED) Report: PEIRPT17
Study Type: 150-DAY DIISOPROPYLCARBODIIMIDE Date: 03/28/05
Route: SKIN APPLICATION Time: 08:45:30
__________________________________________________________________________________________________________________________________
| 0| 1| 1| 1| 1| 1| 1| 1| 1| 1| | |
DAY ON TEST | 9| 3| 4| 4| 4| 4| 4| 4| 4| 4| | |
| 9| 3| 1| 1| 1| 1| 1| 1| 1| 1| | |
__________________________________________|__________________________________________________________________________| T (*) |
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | O |
TGAC (FVB/N) HEMIZYGOUS FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | T |
ANIMAL ID | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | A |
8.75 | 2| 2| 2| 2| 2| 2| 2| 2| 2| 3| | L |
MG/KG | 4| 3| 1| 2| 5| 6| 7| 8| 9| 0| | |
_____________________________________________________________________________________________________________________|____________|
ALIMENTARY SYSTEM | | |
|__________________________________________________________________________|____________|
Esophagus | + + | 2 |
|__________________________________________________________________________|____________|
Gallbladder | + + | 2 |
|__________________________________________________________________________|____________|
Intestine Large, Colon | + + | 2 |
|__________________________________________________________________________|____________|
Intestine Large, Rectum | + + | 2 |
|__________________________________________________________________________|____________|
Intestine Large, Cecum | + + | 2 |
|__________________________________________________________________________|____________|
Intestine Small, Duodenum | + + | 2 |
|__________________________________________________________________________|____________|
Intestine Small, Jejunum | + + | 2 |
|__________________________________________________________________________|____________|
Intestine Small, Ileum | + + | 2 |
|__________________________________________________________________________|____________|
Liver | + + + + + + + | 7 |
|__________________________________________________________________________|____________|
Pancreas | + + | 2 |
|__________________________________________________________________________|____________|
Salivary Glands | + + | 2 |
|__________________________________________________________________________|____________|
Stomach, Forestomach | + + + | 3 |
Squamous Cell Papilloma | X X | 2 |
|__________________________________________________________________________|____________|
Stomach, Glandular | + + | 2 |
|__________________________________________________________________________|____________|
Tooth | M + + + + | 4 |
Odontoma | X X X X | 4 |
_____________________________________________________________________________________________________________________| |
CARDIOVASCULAR SYSTEM | | |
|__________________________________________________________________________|____________|
_____________________________________________________________________________________________________________________|____________|
* : Total animals with tissue examined microscopically; total animals with tumor
+ : Tissue examined microscopically M : Missing tissue
X : Lesion present A : Autolysis precludes evaluation
I : Insufficient tissue BLANK : Not examined microscopically
Page 10
NTP Experiment-Test: 93020-05 NEOPLASMS BY INDIVIDUAL ANIMAL (SYSTEMIC LESIONS ABRIDGED) Report: PEIRPT17
Study Type: 150-DAY DIISOPROPYLCARBODIIMIDE Date: 03/28/05
Route: SKIN APPLICATION Time: 08:45:30
__________________________________________________________________________________________________________________________________
| 0| 1| 1| 1| 1| 1| 1| 1| 1| 1| | |
DAY ON TEST | 9| 3| 4| 4| 4| 4| 4| 4| 4| 4| | |
| 9| 3| 1| 1| 1| 1| 1| 1| 1| 1| | |
__________________________________________|__________________________________________________________________________| T (*) |
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | O |
TGAC (FVB/N) HEMIZYGOUS FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | T |
ANIMAL ID | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | A |
8.75 | 2| 2| 2| 2| 2| 2| 2| 2| 2| 3| | L |
MG/KG | 4| 3| 1| 2| 5| 6| 7| 8| 9| 0| | |
_____________________________________________________________________________________________________________________|____________|
CARDIOVASCULAR SYSTEM - cont | | |
| | |
Blood Vessel | + + | 2 |
|__________________________________________________________________________|____________|
Heart | + + | 2 |
_____________________________________________________________________________________________________________________| |
ENDOCRINE SYSTEM | | |
|__________________________________________________________________________|____________|
Adrenal Cortex | + + + | 3 |
|__________________________________________________________________________|____________|
Adrenal Medulla | + + | 2 |
|__________________________________________________________________________|____________|
Islets, Pancreatic | + + | 2 |
|__________________________________________________________________________|____________|
Parathyroid Gland | M M | |
|__________________________________________________________________________|____________|
Pituitary Gland | M + | 1 |
|__________________________________________________________________________|____________|
Thyroid Gland | + + | 2 |
_____________________________________________________________________________________________________________________| |
GENERAL BODY SYSTEM | | |
None | | |
_____________________________________________________________________________________________________________________| |
GENITAL SYSTEM | | |
|__________________________________________________________________________|____________|
Clitoral Gland | M + | 1 |
|__________________________________________________________________________|____________|
Ovary | + + | 2 |
Yolk Sac Carcinoma | X | 1 |
|__________________________________________________________________________|____________|
Uterus | + + | 2 |
_____________________________________________________________________________________________________________________| |
HEMATOPOIETIC SYSTEM | | |
|__________________________________________________________________________|____________|
_____________________________________________________________________________________________________________________|____________|
* : Total animals with tissue examined microscopically; total animals with tumor
+ : Tissue examined microscopically M : Missing tissue
X : Lesion present A : Autolysis precludes evaluation
I : Insufficient tissue BLANK : Not examined microscopically
Page 11
NTP Experiment-Test: 93020-05 NEOPLASMS BY INDIVIDUAL ANIMAL (SYSTEMIC LESIONS ABRIDGED) Report: PEIRPT17
Study Type: 150-DAY DIISOPROPYLCARBODIIMIDE Date: 03/28/05
Route: SKIN APPLICATION Time: 08:45:30
__________________________________________________________________________________________________________________________________
| 0| 1| 1| 1| 1| 1| 1| 1| 1| 1| | |
DAY ON TEST | 9| 3| 4| 4| 4| 4| 4| 4| 4| 4| | |
| 9| 3| 1| 1| 1| 1| 1| 1| 1| 1| | |
__________________________________________|__________________________________________________________________________| T (*) |
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | O |
TGAC (FVB/N) HEMIZYGOUS FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | T |
ANIMAL ID | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | A |
8.75 | 2| 2| 2| 2| 2| 2| 2| 2| 2| 3| | L |
MG/KG | 4| 3| 1| 2| 5| 6| 7| 8| 9| 0| | |
_____________________________________________________________________________________________________________________|____________|
HEMATOPOIETIC SYSTEM - cont | | |
| | |
Bone Marrow | + + | 2 |
|__________________________________________________________________________|____________|
Lymph Node | + | 1 |
|__________________________________________________________________________|____________|
Lymph Node, Mandibular | + + | 2 |
|__________________________________________________________________________|____________|
Lymph Node, Mesenteric | + + | 2 |
|__________________________________________________________________________|____________|
Spleen | + + + | 3 |
|__________________________________________________________________________|____________|
Thymus | + + | 2 |
_____________________________________________________________________________________________________________________| |
INTEGUMENTARY SYSTEM | | |
|__________________________________________________________________________|____________|
Mammary Gland | + + | 2 |
|__________________________________________________________________________|____________|
Skin | + + + + | 4 |
Squamous Cell Papilloma, Multiple | X | 1 |
Dermis, Skin, Site of Application, | | |
Fibrosarcoma | X | 1 |
Skin, Site of Application, Squamous | | |
Cell Papilloma, Multiple | X | 1 |
_____________________________________________________________________________________________________________________| |
MUSCULOSKELETAL SYSTEM | | |
|__________________________________________________________________________|____________|
Bone | + + | 2 |
_____________________________________________________________________________________________________________________| |
NERVOUS SYSTEM | | |
|__________________________________________________________________________|____________|
Brain | + + | 2 |
_____________________________________________________________________________________________________________________| |
RESPIRATORY SYSTEM | | |
_____________________________________________________________________________________________________________________|____________|
* : Total animals with tissue examined microscopically; total animals with tumor
+ : Tissue examined microscopically M : Missing tissue
X : Lesion present A : Autolysis precludes evaluation
I : Insufficient tissue BLANK : Not examined microscopically
Page 12
NTP Experiment-Test: 93020-05 NEOPLASMS BY INDIVIDUAL ANIMAL (SYSTEMIC LESIONS ABRIDGED) Report: PEIRPT17
Study Type: 150-DAY DIISOPROPYLCARBODIIMIDE Date: 03/28/05
Route: SKIN APPLICATION Time: 08:45:30
__________________________________________________________________________________________________________________________________
| 0| 1| 1| 1| 1| 1| 1| 1| 1| 1| | |
DAY ON TEST | 9| 3| 4| 4| 4| 4| 4| 4| 4| 4| | |
| 9| 3| 1| 1| 1| 1| 1| 1| 1| 1| | |
__________________________________________|__________________________________________________________________________| T (*) |
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | O |
TGAC (FVB/N) HEMIZYGOUS FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | T |
ANIMAL ID | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | A |
8.75 | 2| 2| 2| 2| 2| 2| 2| 2| 2| 3| | L |
MG/KG | 4| 3| 1| 2| 5| 6| 7| 8| 9| 0| | |
_____________________________________________________________________________________________________________________|____________|
RESPIRATORY SYSTEM - cont | | |
| | |
|__________________________________________________________________________|____________|
Lung | + + | 2 |
|__________________________________________________________________________|____________|
Nose | M + | 1 |
|__________________________________________________________________________|____________|
Trachea | + + | 2 |
_____________________________________________________________________________________________________________________| |
SPECIAL SENSES SYSTEM | | |
None | | |
_____________________________________________________________________________________________________________________| |
URINARY SYSTEM | | |
|__________________________________________________________________________|____________|
Kidney | + + | 2 |
|__________________________________________________________________________|____________|
Urinary Bladder | + + | 2 |
__________________________________________________________________________________________________________________________________
SYSTEMIC LESIONS | | |
__________________________________________________________________________|____________|
Multiple Organs | + + + + + + + + + + | 10 |
__________________________________________________________________________________________________________________________________
* : Total animals with tissue examined microscopically; total animals with tumor
+ : Tissue examined microscopically M : Missing tissue
X : Lesion present A : Autolysis precludes evaluation
I : Insufficient tissue BLANK : Not examined microscopically
Page 13
NTP Experiment-Test: 93020-05 NEOPLASMS BY INDIVIDUAL ANIMAL (SYSTEMIC LESIONS ABRIDGED) Report: PEIRPT17
Study Type: 150-DAY DIISOPROPYLCARBODIIMIDE Date: 03/28/05
Route: SKIN APPLICATION Time: 08:45:30
__________________________________________________________________________________________________________________________________
| 0| 1| 1| 1| 1| 1| 1| 1| 1| 1| | |
DAY ON TEST | 8| 0| 4| 4| 4| 4| 4| 4| 4| 4| | |
| 2| 8| 1| 1| 1| 1| 1| 1| 1| 1| | |
__________________________________________|__________________________________________________________________________| T (*) |
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | O |
TGAC (FVB/N) HEMIZYGOUS FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | T |
ANIMAL ID | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | A |
17.5 | 3| 4| 3| 3| 3| 3| 3| 3| 3| 3| | L |
MG/KG | 5| 0| 1| 2| 3| 4| 6| 7| 8| 9| | |
_____________________________________________________________________________________________________________________|____________|
ALIMENTARY SYSTEM | | |
|__________________________________________________________________________|____________|
Esophagus | + + | 2 |
|__________________________________________________________________________|____________|
Gallbladder | A + | 1 |
|__________________________________________________________________________|____________|
Intestine Large, Colon | A + | 1 |
|__________________________________________________________________________|____________|
Intestine Large, Rectum | A + | 1 |
|__________________________________________________________________________|____________|
Intestine Large, Cecum | A + | 1 |
|__________________________________________________________________________|____________|
Intestine Small, Duodenum | A + | 1 |
|__________________________________________________________________________|____________|
Intestine Small, Jejunum | A + | 1 |
|__________________________________________________________________________|____________|
Intestine Small, Ileum | A + | 1 |
|__________________________________________________________________________|____________|
Liver | A + + + + + + + | 7 |
|__________________________________________________________________________|____________|
Pancreas | A + | 1 |
|__________________________________________________________________________|____________|
Salivary Glands | + + | 2 |
|__________________________________________________________________________|____________|
Stomach, Forestomach | + + + | 3 |
Squamous Cell Papilloma | X X | 2 |
|__________________________________________________________________________|____________|
Stomach, Glandular | + + | 2 |
|__________________________________________________________________________|____________|
Tooth | + + + + + + | 6 |
Odontoma | X X X X X X | 6 |
_____________________________________________________________________________________________________________________| |
CARDIOVASCULAR SYSTEM | | |
|__________________________________________________________________________|____________|
_____________________________________________________________________________________________________________________|____________|
* : Total animals with tissue examined microscopically; total animals with tumor
+ : Tissue examined microscopically M : Missing tissue
X : Lesion present A : Autolysis precludes evaluation
I : Insufficient tissue BLANK : Not examined microscopically
Page 14
NTP Experiment-Test: 93020-05 NEOPLASMS BY INDIVIDUAL ANIMAL (SYSTEMIC LESIONS ABRIDGED) Report: PEIRPT17
Study Type: 150-DAY DIISOPROPYLCARBODIIMIDE Date: 03/28/05
Route: SKIN APPLICATION Time: 08:45:30
__________________________________________________________________________________________________________________________________
| 0| 1| 1| 1| 1| 1| 1| 1| 1| 1| | |
DAY ON TEST | 8| 0| 4| 4| 4| 4| 4| 4| 4| 4| | |
| 2| 8| 1| 1| 1| 1| 1| 1| 1| 1| | |
__________________________________________|__________________________________________________________________________| T (*) |
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | O |
TGAC (FVB/N) HEMIZYGOUS FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | T |
ANIMAL ID | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | A |
17.5 | 3| 4| 3| 3| 3| 3| 3| 3| 3| 3| | L |
MG/KG | 5| 0| 1| 2| 3| 4| 6| 7| 8| 9| | |
_____________________________________________________________________________________________________________________|____________|
CARDIOVASCULAR SYSTEM - cont | | |
| | |
Blood Vessel | + + | 2 |
|__________________________________________________________________________|____________|
Heart | + + | 2 |
_____________________________________________________________________________________________________________________| |
ENDOCRINE SYSTEM | | |
|__________________________________________________________________________|____________|
Adrenal Cortex | + + + | 3 |
|__________________________________________________________________________|____________|
Adrenal Medulla | + + | 2 |
|__________________________________________________________________________|____________|
Islets, Pancreatic | A + | 1 |
|__________________________________________________________________________|____________|
Parathyroid Gland | + M | 1 |
|__________________________________________________________________________|____________|
Pituitary Gland | I + | 1 |
|__________________________________________________________________________|____________|
Thyroid Gland | + + | 2 |
_____________________________________________________________________________________________________________________| |
GENERAL BODY SYSTEM | | |
None | | |
_____________________________________________________________________________________________________________________| |
GENITAL SYSTEM | | |
|__________________________________________________________________________|____________|
Clitoral Gland | M + | 1 |
|__________________________________________________________________________|____________|
Ovary | + + | 2 |
|__________________________________________________________________________|____________|
Uterus | + + | 2 |
_____________________________________________________________________________________________________________________| |
HEMATOPOIETIC SYSTEM | | |
|__________________________________________________________________________|____________|
Bone Marrow | + + | 2 |
_____________________________________________________________________________________________________________________|____________|
* : Total animals with tissue examined microscopically; total animals with tumor
+ : Tissue examined microscopically M : Missing tissue
X : Lesion present A : Autolysis precludes evaluation
I : Insufficient tissue BLANK : Not examined microscopically
Page 15
NTP Experiment-Test: 93020-05 NEOPLASMS BY INDIVIDUAL ANIMAL (SYSTEMIC LESIONS ABRIDGED) Report: PEIRPT17
Study Type: 150-DAY DIISOPROPYLCARBODIIMIDE Date: 03/28/05
Route: SKIN APPLICATION Time: 08:45:30
__________________________________________________________________________________________________________________________________
| 0| 1| 1| 1| 1| 1| 1| 1| 1| 1| | |
DAY ON TEST | 8| 0| 4| 4| 4| 4| 4| 4| 4| 4| | |
| 2| 8| 1| 1| 1| 1| 1| 1| 1| 1| | |
__________________________________________|__________________________________________________________________________| T (*) |
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | O |
TGAC (FVB/N) HEMIZYGOUS FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | T |
ANIMAL ID | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | A |
17.5 | 3| 4| 3| 3| 3| 3| 3| 3| 3| 3| | L |
MG/KG | 5| 0| 1| 2| 3| 4| 6| 7| 8| 9| | |
_____________________________________________________________________________________________________________________|____________|
HEMATOPOIETIC SYSTEM - cont | | |
| | |
|__________________________________________________________________________|____________|
Lymph Node | + | 1 |
|__________________________________________________________________________|____________|
Lymph Node, Mandibular | + M | 1 |
|__________________________________________________________________________|____________|
Lymph Node, Mesenteric | A + | 1 |
|__________________________________________________________________________|____________|
Spleen | A + + + | 3 |
|__________________________________________________________________________|____________|
Thymus | M M | |
_____________________________________________________________________________________________________________________| |
INTEGUMENTARY SYSTEM | | |
|__________________________________________________________________________|____________|
Mammary Gland | + + | 2 |
|__________________________________________________________________________|____________|
Skin | + + + + | 4 |
Squamous Cell Papilloma | X | 1 |
Skin, Site of Application, Squamous | | |
Cell Papilloma, Multiple | X | 1 |
_____________________________________________________________________________________________________________________| |
MUSCULOSKELETAL SYSTEM | | |
|__________________________________________________________________________|____________|
Bone | + + | 2 |
_____________________________________________________________________________________________________________________| |
NERVOUS SYSTEM | | |
|__________________________________________________________________________|____________|
Brain | + + | 2 |
_____________________________________________________________________________________________________________________| |
RESPIRATORY SYSTEM | | |
|__________________________________________________________________________|____________|
Lung | + + + | 3 |
|__________________________________________________________________________|____________|
_____________________________________________________________________________________________________________________|____________|
* : Total animals with tissue examined microscopically; total animals with tumor
+ : Tissue examined microscopically M : Missing tissue
X : Lesion present A : Autolysis precludes evaluation
I : Insufficient tissue BLANK : Not examined microscopically
Page 16
NTP Experiment-Test: 93020-05 NEOPLASMS BY INDIVIDUAL ANIMAL (SYSTEMIC LESIONS ABRIDGED) Report: PEIRPT17
Study Type: 150-DAY DIISOPROPYLCARBODIIMIDE Date: 03/28/05
Route: SKIN APPLICATION Time: 08:45:30
__________________________________________________________________________________________________________________________________
| 0| 1| 1| 1| 1| 1| 1| 1| 1| 1| | |
DAY ON TEST | 8| 0| 4| 4| 4| 4| 4| 4| 4| 4| | |
| 2| 8| 1| 1| 1| 1| 1| 1| 1| 1| | |
__________________________________________|__________________________________________________________________________| T (*) |
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | O |
TGAC (FVB/N) HEMIZYGOUS FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | T |
ANIMAL ID | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | A |
17.5 | 3| 4| 3| 3| 3| 3| 3| 3| 3| 3| | L |
MG/KG | 5| 0| 1| 2| 3| 4| 6| 7| 8| 9| | |
_____________________________________________________________________________________________________________________|____________|
RESPIRATORY SYSTEM - cont | | |
| | |
Nose | + + | 2 |
|__________________________________________________________________________|____________|
Trachea | + + | 2 |
_____________________________________________________________________________________________________________________| |
SPECIAL SENSES SYSTEM | | |
None | | |
_____________________________________________________________________________________________________________________| |
URINARY SYSTEM | | |
|__________________________________________________________________________|____________|
Kidney | + + | 2 |
|__________________________________________________________________________|____________|
Urinary Bladder | + + | 2 |
__________________________________________________________________________________________________________________________________
SYSTEMIC LESIONS | | |
__________________________________________________________________________|____________|
Multiple Organs | + + + + + + + + + | 9 |
__________________________________________________________________________________________________________________________________
* : Total animals with tissue examined microscopically; total animals with tumor
+ : Tissue examined microscopically M : Missing tissue
X : Lesion present A : Autolysis precludes evaluation
I : Insufficient tissue BLANK : Not examined microscopically
Page 17
NTP Experiment-Test: 93020-05 NEOPLASMS BY INDIVIDUAL ANIMAL (SYSTEMIC LESIONS ABRIDGED) Report: PEIRPT17
Study Type: 150-DAY DIISOPROPYLCARBODIIMIDE Date: 03/28/05
Route: SKIN APPLICATION Time: 08:45:30
__________________________________________________________________________________________________________________________________
| 0| 0| 0| 0| 1| 1| 1| 1| 1| 1| | |
DAY ON TEST | 4| 4| 5| 6| 4| 4| 4| 4| 4| 4| | |
| 5| 8| 4| 6| 1| 1| 1| 1| 1| 1| | |
__________________________________________|__________________________________________________________________________| T (*) |
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | O |
TGAC (FVB/N) HEMIZYGOUS FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | T |
ANIMAL ID | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | A |
35 | 4| 4| 5| 4| 4| 4| 4| 4| 4| 4| | L |
MG/KG | 4| 3| 0| 6| 1| 2| 5| 7| 8| 9| | |
_____________________________________________________________________________________________________________________|____________|
ALIMENTARY SYSTEM | | |
|__________________________________________________________________________|____________|
Esophagus | + + + M | 3 |
|__________________________________________________________________________|____________|
Gallbladder | M + M + | 2 |
|__________________________________________________________________________|____________|
Intestine Large, Colon | A + A + | 2 |
|__________________________________________________________________________|____________|
Intestine Large, Rectum | A + A + | 2 |
|__________________________________________________________________________|____________|
Intestine Large, Cecum | A + A + | 2 |
|__________________________________________________________________________|____________|
Intestine Small, Duodenum | A + A + | 2 |
|__________________________________________________________________________|____________|
Intestine Small, Jejunum | A + A + | 2 |
|__________________________________________________________________________|____________|
Intestine Small, Ileum | A + A + | 2 |
|__________________________________________________________________________|____________|
Liver | + + + + + + | 6 |
|__________________________________________________________________________|____________|
Pancreas | + + + + | 4 |
|__________________________________________________________________________|____________|
Salivary Glands | + + + + | 4 |
Duct, Squamous Cell Carcinoma | X | 1 |
|__________________________________________________________________________|____________|
Stomach, Forestomach | A + A + | 2 |
|__________________________________________________________________________|____________|
Stomach, Glandular | A + A + | 2 |
|__________________________________________________________________________|____________|
Tongue | + | 1 |
|__________________________________________________________________________|____________|
Tooth | + + + | 3 |
Odontoma | X | 1 |
_____________________________________________________________________________________________________________________| |
* : Total animals with tissue examined microscopically; total animals with tumor
+ : Tissue examined microscopically M : Missing tissue
X : Lesion present A : Autolysis precludes evaluation
I : Insufficient tissue BLANK : Not examined microscopically
Page 18
NTP Experiment-Test: 93020-05 NEOPLASMS BY INDIVIDUAL ANIMAL (SYSTEMIC LESIONS ABRIDGED) Report: PEIRPT17
Study Type: 150-DAY DIISOPROPYLCARBODIIMIDE Date: 03/28/05
Route: SKIN APPLICATION Time: 08:45:30
__________________________________________________________________________________________________________________________________
| 0| 0| 0| 0| 1| 1| 1| 1| 1| 1| | |
DAY ON TEST | 4| 4| 5| 6| 4| 4| 4| 4| 4| 4| | |
| 5| 8| 4| 6| 1| 1| 1| 1| 1| 1| | |
__________________________________________|__________________________________________________________________________| T (*) |
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | O |
TGAC (FVB/N) HEMIZYGOUS FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | T |
ANIMAL ID | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | A |
35 | 4| 4| 5| 4| 4| 4| 4| 4| 4| 4| | L |
MG/KG | 4| 3| 0| 6| 1| 2| 5| 7| 8| 9| | |
_____________________________________________________________________________________________________________________|____________|
CARDIOVASCULAR SYSTEM | | |
|__________________________________________________________________________|____________|
Blood Vessel | + + + + | 4 |
|__________________________________________________________________________|____________|
Heart | + + + + | 4 |
_____________________________________________________________________________________________________________________| |
ENDOCRINE SYSTEM | | |
|__________________________________________________________________________|____________|
Adrenal Cortex | + + + + + | 5 |
|__________________________________________________________________________|____________|
Adrenal Medulla | + + + + | 4 |
|__________________________________________________________________________|____________|
Islets, Pancreatic | + + + + | 4 |
|__________________________________________________________________________|____________|
Parathyroid Gland | M M M M | |
|__________________________________________________________________________|____________|
Pituitary Gland | M + M + | 2 |
|__________________________________________________________________________|____________|
Thyroid Gland | + + + + | 4 |
_____________________________________________________________________________________________________________________| |
GENERAL BODY SYSTEM | | |
None | | |
_____________________________________________________________________________________________________________________| |
GENITAL SYSTEM | | |
|__________________________________________________________________________|____________|
Clitoral Gland | M + M + | 2 |
|__________________________________________________________________________|____________|
Ovary | + + + + | 4 |
Teratoma Benign | X X | 2 |
|__________________________________________________________________________|____________|
Uterus | + + + + | 4 |
_____________________________________________________________________________________________________________________| |
HEMATOPOIETIC SYSTEM | | |
|__________________________________________________________________________|____________|
_____________________________________________________________________________________________________________________|____________|
* : Total animals with tissue examined microscopically; total animals with tumor
+ : Tissue examined microscopically M : Missing tissue
X : Lesion present A : Autolysis precludes evaluation
I : Insufficient tissue BLANK : Not examined microscopically
Page 19
NTP Experiment-Test: 93020-05 NEOPLASMS BY INDIVIDUAL ANIMAL (SYSTEMIC LESIONS ABRIDGED) Report: PEIRPT17
Study Type: 150-DAY DIISOPROPYLCARBODIIMIDE Date: 03/28/05
Route: SKIN APPLICATION Time: 08:45:30
__________________________________________________________________________________________________________________________________
| 0| 0| 0| 0| 1| 1| 1| 1| 1| 1| | |
DAY ON TEST | 4| 4| 5| 6| 4| 4| 4| 4| 4| 4| | |
| 5| 8| 4| 6| 1| 1| 1| 1| 1| 1| | |
__________________________________________|__________________________________________________________________________| T (*) |
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | O |
TGAC (FVB/N) HEMIZYGOUS FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | T |
ANIMAL ID | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | A |
35 | 4| 4| 5| 4| 4| 4| 4| 4| 4| 4| | L |
MG/KG | 4| 3| 0| 6| 1| 2| 5| 7| 8| 9| | |
_____________________________________________________________________________________________________________________|____________|
HEMATOPOIETIC SYSTEM - cont | | |
| | |
Bone Marrow | + + + + | 4 |
|__________________________________________________________________________|____________|
Lymph Node, Mandibular | + + + + | 4 |
|__________________________________________________________________________|____________|
Lymph Node, Mesenteric | + + A + + | 4 |
|__________________________________________________________________________|____________|
Spleen | A + + + + + + | 6 |
|__________________________________________________________________________|____________|
Thymus | + + A + | 3 |
_____________________________________________________________________________________________________________________| |
INTEGUMENTARY SYSTEM | | |
|__________________________________________________________________________|____________|
Mammary Gland | + M M + | 2 |
|__________________________________________________________________________|____________|
Skin | + + + + | 4 |
_____________________________________________________________________________________________________________________| |
MUSCULOSKELETAL SYSTEM | | |
|__________________________________________________________________________|____________|
Bone | + + + + | 4 |
_____________________________________________________________________________________________________________________| |
NERVOUS SYSTEM | | |
|__________________________________________________________________________|____________|
Brain | + + + + | 4 |
_____________________________________________________________________________________________________________________| |
RESPIRATORY SYSTEM | | |
|__________________________________________________________________________|____________|
Lung | + + + + | 4 |
|__________________________________________________________________________|____________|
Nose | + + + + | 4 |
|__________________________________________________________________________|____________|
Trachea | + + + + | 4 |
_____________________________________________________________________________________________________________________| |
SPECIAL SENSES SYSTEM | | |
None | | |
_____________________________________________________________________________________________________________________|____________|
* : Total animals with tissue examined microscopically; total animals with tumor
+ : Tissue examined microscopically M : Missing tissue
X : Lesion present A : Autolysis precludes evaluation
I : Insufficient tissue BLANK : Not examined microscopically
Page 20
NTP Experiment-Test: 93020-05 NEOPLASMS BY INDIVIDUAL ANIMAL (SYSTEMIC LESIONS ABRIDGED) Report: PEIRPT17
Study Type: 150-DAY DIISOPROPYLCARBODIIMIDE Date: 03/28/05
Route: SKIN APPLICATION Time: 08:45:30
__________________________________________________________________________________________________________________________________
| 0| 0| 0| 0| 1| 1| 1| 1| 1| 1| | |
DAY ON TEST | 4| 4| 5| 6| 4| 4| 4| 4| 4| 4| | |
| 5| 8| 4| 6| 1| 1| 1| 1| 1| 1| | |
__________________________________________|__________________________________________________________________________| T (*) |
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | O |
TGAC (FVB/N) HEMIZYGOUS FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | T |
ANIMAL ID | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | A |
35 | 4| 4| 5| 4| 4| 4| 4| 4| 4| 4| | L |
MG/KG | 4| 3| 0| 6| 1| 2| 5| 7| 8| 9| | |
_____________________________________________________________________________________________________________________|____________|
URINARY SYSTEM | | |
|__________________________________________________________________________|____________|
Kidney | + + + + | 4 |
|__________________________________________________________________________|____________|
Urinary Bladder | + + + + | 4 |
__________________________________________________________________________________________________________________________________
SYSTEMIC LESIONS | | |
__________________________________________________________________________|____________|
Multiple Organs | + + + + + + + + + | 9 |
__________________________________________________________________________________________________________________________________
* : Total animals with tissue examined microscopically; total animals with tumor
+ : Tissue examined microscopically M : Missing tissue
X : Lesion present A : Autolysis precludes evaluation
I : Insufficient tissue BLANK : Not examined microscopically
Page 21
NTP Experiment-Test: 93020-05 NEOPLASMS BY INDIVIDUAL ANIMAL (SYSTEMIC LESIONS ABRIDGED) Report: PEIRPT17
Study Type: 150-DAY DIISOPROPYLCARBODIIMIDE Date: 03/28/05
Route: SKIN APPLICATION Time: 08:45:30
__________________________________________________________________________________________________________________________________
| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| | |
DAY ON TEST | 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| | |
| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| | |
__________________________________________|__________________________________________________________________________| T (*) |
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | O |
TGAC (FVB/N) HEMIZYGOUS FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | T |
ANIMAL ID | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | A |
70 | 5| 5| 5| 5| 5| 5| 5| 5| 5| 6| | L |
MG/KG | 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| | |
_____________________________________________________________________________________________________________________|____________|
ALIMENTARY SYSTEM | | |
|__________________________________________________________________________|____________|
Esophagus | + + + + + + + + + + | 10 |
|__________________________________________________________________________|____________|
Gallbladder | + + + + + I + + + + | 9 |
|__________________________________________________________________________|____________|
Intestine Large, Colon | + + + + + + + + + + | 10 |
|__________________________________________________________________________|____________|
Intestine Large, Rectum | + + + + + + + + + + | 10 |
|__________________________________________________________________________|____________|
Intestine Large, Cecum | + + + + + + + + + + | 10 |
|__________________________________________________________________________|____________|
Intestine Small, Duodenum | + + + + + + + + + + | 10 |
|__________________________________________________________________________|____________|
Intestine Small, Jejunum | + + + + + + + + + + | 10 |
|__________________________________________________________________________|____________|
Intestine Small, Ileum | + + + + + + + + + + | 10 |
|__________________________________________________________________________|____________|
Liver | + + + + + + + + + + | 10 |
|__________________________________________________________________________|____________|
Pancreas | + + + + + + + + + + | 10 |
|__________________________________________________________________________|____________|
Salivary Glands | + + + + + + + + + + | 10 |
|__________________________________________________________________________|____________|
Stomach, Forestomach | + + + + + + + + + + | 10 |
Squamous Cell Papilloma | X X | 2 |
|__________________________________________________________________________|____________|
Stomach, Glandular | + + + + + + + + + + | 10 |
|__________________________________________________________________________|____________|
Tooth | + + + + + + + | 7 |
Odontoma | X X X X X X | 6 |
_____________________________________________________________________________________________________________________| |
CARDIOVASCULAR SYSTEM | | |
|__________________________________________________________________________|____________|
_____________________________________________________________________________________________________________________|____________|
* : Total animals with tissue examined microscopically; total animals with tumor
+ : Tissue examined microscopically M : Missing tissue
X : Lesion present A : Autolysis precludes evaluation
I : Insufficient tissue BLANK : Not examined microscopically
Page 22
NTP Experiment-Test: 93020-05 NEOPLASMS BY INDIVIDUAL ANIMAL (SYSTEMIC LESIONS ABRIDGED) Report: PEIRPT17
Study Type: 150-DAY DIISOPROPYLCARBODIIMIDE Date: 03/28/05
Route: SKIN APPLICATION Time: 08:45:30
__________________________________________________________________________________________________________________________________
| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| | |
DAY ON TEST | 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| | |
| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| | |
__________________________________________|__________________________________________________________________________| T (*) |
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | O |
TGAC (FVB/N) HEMIZYGOUS FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | T |
ANIMAL ID | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | A |
70 | 5| 5| 5| 5| 5| 5| 5| 5| 5| 6| | L |
MG/KG | 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| | |
_____________________________________________________________________________________________________________________|____________|
CARDIOVASCULAR SYSTEM - cont | | |
| | |
Blood Vessel | + + + + + + + + + + | 10 |
|__________________________________________________________________________|____________|
Heart | + + + + + + + + + + | 10 |
_____________________________________________________________________________________________________________________| |
ENDOCRINE SYSTEM | | |
|__________________________________________________________________________|____________|
Adrenal Cortex | + + + + + + + + + + | 10 |
|__________________________________________________________________________|____________|
Adrenal Medulla | + + + + + + + + + + | 10 |
|__________________________________________________________________________|____________|
Islets, Pancreatic | + + + + + + + + + + | 10 |
|__________________________________________________________________________|____________|
Parathyroid Gland | M M + M + + M M + + | 5 |
|__________________________________________________________________________|____________|
Pituitary Gland | + + M M + + + + M M | 6 |
|__________________________________________________________________________|____________|
Thyroid Gland | + + + + + + + M + + | 9 |
_____________________________________________________________________________________________________________________| |
GENERAL BODY SYSTEM | | |
None | | |
_____________________________________________________________________________________________________________________| |
GENITAL SYSTEM | | |
|__________________________________________________________________________|____________|
Clitoral Gland | + + + + + + + M + M | 8 |
|__________________________________________________________________________|____________|
Ovary | + + + + + + + + + + | 10 |
|__________________________________________________________________________|____________|
Uterus | + + + + + + + + + + | 10 |
_____________________________________________________________________________________________________________________| |
HEMATOPOIETIC SYSTEM | | |
|__________________________________________________________________________|____________|
Bone Marrow | + + + + + + + + + + | 10 |
_____________________________________________________________________________________________________________________|____________|
* : Total animals with tissue examined microscopically; total animals with tumor
+ : Tissue examined microscopically M : Missing tissue
X : Lesion present A : Autolysis precludes evaluation
I : Insufficient tissue BLANK : Not examined microscopically
Page 23
NTP Experiment-Test: 93020-05 NEOPLASMS BY INDIVIDUAL ANIMAL (SYSTEMIC LESIONS ABRIDGED) Report: PEIRPT17
Study Type: 150-DAY DIISOPROPYLCARBODIIMIDE Date: 03/28/05
Route: SKIN APPLICATION Time: 08:45:30
__________________________________________________________________________________________________________________________________
| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| | |
DAY ON TEST | 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| | |
| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| | |
__________________________________________|__________________________________________________________________________| T (*) |
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | O |
TGAC (FVB/N) HEMIZYGOUS FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | T |
ANIMAL ID | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | A |
70 | 5| 5| 5| 5| 5| 5| 5| 5| 5| 6| | L |
MG/KG | 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| | |
_____________________________________________________________________________________________________________________|____________|
HEMATOPOIETIC SYSTEM - cont | | |
| | |
|__________________________________________________________________________|____________|
Lymph Node, Mandibular | + + + + + + + + + + | 10 |
|__________________________________________________________________________|____________|
Lymph Node, Mesenteric | + + + + + + + + + + | 10 |
|__________________________________________________________________________|____________|
Spleen | + + + + + + + + + + | 10 |
|__________________________________________________________________________|____________|
Thymus | + + + + + + + + + + | 10 |
_____________________________________________________________________________________________________________________| |
INTEGUMENTARY SYSTEM | | |
|__________________________________________________________________________|____________|
Mammary Gland | + + + + + + + + + + | 10 |
|__________________________________________________________________________|____________|
Skin | + + + + + + + + + + | 10 |
Skin, Site of Application, Squamous | | |
Cell Papilloma | X | 1 |
_____________________________________________________________________________________________________________________| |
MUSCULOSKELETAL SYSTEM | | |
|__________________________________________________________________________|____________|
Bone | + + + + + + + + + + | 10 |
_____________________________________________________________________________________________________________________| |
NERVOUS SYSTEM | | |
|__________________________________________________________________________|____________|
Brain | + + + + + + + + + + | 10 |
_____________________________________________________________________________________________________________________| |
RESPIRATORY SYSTEM | | |
|__________________________________________________________________________|____________|
Lung | + + + + + + + + + + | 10 |
|__________________________________________________________________________|____________|
Nose | + + + + + + + + + + | 10 |
|__________________________________________________________________________|____________|
Trachea | + + + + + + + + + + | 10 |
_____________________________________________________________________________________________________________________| |
SPECIAL SENSES SYSTEM | | |
None | | |
_____________________________________________________________________________________________________________________|____________|
* : Total animals with tissue examined microscopically; total animals with tumor
+ : Tissue examined microscopically M : Missing tissue
X : Lesion present A : Autolysis precludes evaluation
I : Insufficient tissue BLANK : Not examined microscopically
Page 24
NTP Experiment-Test: 93020-05 NEOPLASMS BY INDIVIDUAL ANIMAL (SYSTEMIC LESIONS ABRIDGED) Report: PEIRPT17
Study Type: 150-DAY DIISOPROPYLCARBODIIMIDE Date: 03/28/05
Route: SKIN APPLICATION Time: 08:45:30
__________________________________________________________________________________________________________________________________
| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| | |
DAY ON TEST | 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| | |
| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| | |
__________________________________________|__________________________________________________________________________| T (*) |
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | O |
TGAC (FVB/N) HEMIZYGOUS FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | T |
ANIMAL ID | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| | A |
70 | 5| 5| 5| 5| 5| 5| 5| 5| 5| 6| | L |
MG/KG | 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| | |
_____________________________________________________________________________________________________________________|____________|
URINARY SYSTEM | | |
|__________________________________________________________________________|____________|
Kidney | + + + + + + + + + + | 10 |
|__________________________________________________________________________|____________|
Urinary Bladder | + + + + + + + + + + | 10 |
__________________________________________________________________________________________________________________________________
SYSTEMIC LESIONS | | |
__________________________________________________________________________|____________|
Multiple Organs | + + + + + + + + + + | 10 |
__________________________________________________________________________________________________________________________________
* : Total animals with tissue examined microscopically; total animals with tumor
+ : Tissue examined microscopically M : Missing tissue
X : Lesion present A : Autolysis precludes evaluation
I : Insufficient tissue BLANK : Not examined microscopically
Page 25
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