TDMS Study 88004-05 Pathology Tables
NTP Experiment-Test: 88004-05 INCIDENCE RATES OF NONNEOPLASTIC LESIONS BY ANATOMIC SITE (a) Report: PEIRPT18 Study Type: CHRONIC WITH AVERAGE SEVERITY GRADES[b] Date: 12/17/03 Route: RESPIRATORY EXPOSURE WHOLE BODY DIVINYLBENZENE Time: 12:01:01 FINAL #1 RATS Facility: Battelle Northwest Chemical CAS #: 1321-74-0 Lock Date: 04/16/02 Cage Range: All Reasons For Removal: All Removal Date Range: All Treatment Groups: Include All a Number of animals examined microscopically at site and number of animals with lesion b Average severity grade (1-minimal;2-mild;3-moderate;4-marked) Page 1 NTP Experiment-Test: 88004-05 INCIDENCE RATES OF NONNEOPLASTIC LESIONS BY ANATOMIC SITE (a) Report: PEIRPT18 Study Type: CHRONIC WITH AVERAGE SEVERITY GRADES[b] Date: 12/17/03 Route: RESPIRATORY EXPOSURE WHOLE BODY DIVINYLBENZENE Time: 12:01:01 ____________________________________________________________________________________________________________________________________ FISCHER 344 RATS FEMALE CONTROL 100 PPM 200 PPM 400 PPM ____________________________________________________________________________________________________________________________________ DISPOSITION SUMMARY Animals Initially In Study 50 50 50 50 Early Deaths Moribund Sacrifice 10 16 14 26 Natural Death 7 3 3 2 Accidently Killed 1 Survivors Terminal Sacrifice 33 30 33 22 Animals Examined Microscopically 50 50 50 50 ____________________________________________________________________________________________________________________________________ ALIMENTARY SYSTEM Intestine Large, Colon (50) (49) (49) (50) Epithelium, Metaplasia, Focal, Squamous 1 [3.0] Liver (50) (50) (50) (50) Clear Cell Focus 5 [2.0] 7 [2.4] 6 [2.8] Hepatodiaphragmatic Nodule 5 [4.0] 7 [4.0] 6 [3.5] 9 [4.0] Necrosis 1 [3.0] Vacuolization Cytoplasmic 4 [2.0] 3 [3.0] 3 [2.0] Bile Duct, Hyperplasia 1 [4.0] Hepatocyte, Regeneration 1 [4.0] 1 [4.0] Periportal, Inflammation, Chronic 3 [2.3] 2 [3.0] 1 [2.0] 2 [1.5] Portal, Bile Stasis 1 [3.0] 3 [3.7] 2 [3.5] 1 [3.0] Serosa, Fibrosis 1 [3.0] Mesentery (15) (20) (17) (6) Necrosis 14 [3.0] 20 [3.0] 16 [3.1] 6 [3.0] Oral Mucosa (1) Pharyngeal, Ulcer 1 [4.0] Pancreas (50) (49) (50) (50) Acinus, Atrophy 3 [1.7] 5 [1.2] 2 [1.0] 4 [2.8] Salivary Glands (50) (50) (50) (50) Inflammation, Chronic 1 [3.0] Stomach, Forestomach (50) (50) (49) (49) Hyperplasia, Focal, Squamous 1 [4.0] 1 [3.0] Ulcer 1 [4.0] 1 [3.0] 1 [4.0] 1 [4.0] Stomach, Glandular (50) (50) (49) (49) Erosion 1 [2.0] 1 [2.0] Ulcer 1 [4.0] Epithelium, Hyperplasia 1 [2.0] Tongue (1) (1) (3) (3) Epithelium, Hyperplasia 1 [4.0] 3 [2.7] 2 [4.0] a Number of animals examined microscopically at site and number of animals with lesion b Average severity grade (1-minimal;2-mild;3-moderate;4-marked) Page 2 NTP Experiment-Test: 88004-05 INCIDENCE RATES OF NONNEOPLASTIC LESIONS BY ANATOMIC SITE (a) Report: PEIRPT18 Study Type: CHRONIC WITH AVERAGE SEVERITY GRADES[b] Date: 12/17/03 Route: RESPIRATORY EXPOSURE WHOLE BODY DIVINYLBENZENE Time: 12:01:01 ____________________________________________________________________________________________________________________________________ FISCHER 344 RATS FEMALE CONTROL 100 PPM 200 PPM 400 PPM ____________________________________________________________________________________________________________________________________ ALIMENTARY SYSTEM - CONT Tooth (1) Peridontal Tissue, Inflammation 1 [4.0] Pulp, Inflammation, Suppurative 1 [4.0] ____________________________________________________________________________________________________________________________________ CARDIOVASCULAR SYSTEM Heart (50) (50) (50) (50) Cardiomyopathy 3 [1.7] Atrium, Thrombosis 1 [4.0] 2 [4.0] Pericardium, Infiltration Cellular, Lymphoid 1 [3.0] ____________________________________________________________________________________________________________________________________ ENDOCRINE SYSTEM Adrenal Cortex (50) (50) (50) (50) Accessory Adrenal Cortical Nodule 1 [4.0] Hemorrhage 1 [2.0] Hyperplasia 1 [2.0] Necrosis 1 [4.0] Vacuolization Cytoplasmic 14 [1.9] 5 [1.8] 7 [1.6] 12 [1.5] Adrenal Medulla (50) (50) (50) (50) Hyperplasia 1 [2.0] 1 [2.0] 5 [2.6] 2 [3.0] Parathyroid Gland (49) (49) (47) (49) Hyperplasia 1 [2.0] Pituitary Gland (50) (50) (50) (50) Cyst 6 [3.5] 6 [2.8] 1 [4.0] 5 [2.8] Pars Distalis, Angiectasis 1 [3.0] Pars Distalis, Hematocyst 1 [4.0] Pars Distalis, Hyperplasia 4 [3.0] 8 [2.9] 4 [3.0] 7 [2.3] Thyroid Gland (50) (50) (50) (50) Ultimobranchial Cyst 1 [2.0] C-Cell, Hyperplasia 5 [2.8] 8 [2.0] 6 [1.8] 1 [1.0] Follicular Cell, Hyperplasia 1 [2.0] 1 [2.0] ____________________________________________________________________________________________________________________________________ GENERAL BODY SYSTEM None ____________________________________________________________________________________________________________________________________ GENITAL SYSTEM a Number of animals examined microscopically at site and number of animals with lesion b Average severity grade (1-minimal;2-mild;3-moderate;4-marked) Page 3 NTP Experiment-Test: 88004-05 INCIDENCE RATES OF NONNEOPLASTIC LESIONS BY ANATOMIC SITE (a) Report: PEIRPT18 Study Type: CHRONIC WITH AVERAGE SEVERITY GRADES[b] Date: 12/17/03 Route: RESPIRATORY EXPOSURE WHOLE BODY DIVINYLBENZENE Time: 12:01:01 ____________________________________________________________________________________________________________________________________ FISCHER 344 RATS FEMALE CONTROL 100 PPM 200 PPM 400 PPM ____________________________________________________________________________________________________________________________________ GENITAL SYSTEM - CONT Clitoral Gland (50) (50) (50) (50) Cyst 3 [3.7] 1 [4.0] Hyperplasia 1 [3.0] 3 [4.0] 2 [2.5] 2 [4.0] Inflammation, Chronic 2 [3.5] 1 [2.0] 1 [3.0] Ovary (50) (50) (50) (50) Cyst 5 [3.6] 6 [2.7] 11 [3.2] 4 [2.8] Bilateral, Cyst 1 [3.0] Uterus (50) (50) (50) (50) Hemorrhage 1 [4.0] Necrosis 1 [4.0] Endometrium, Hyperplasia 2 [2.5] 1 [2.0] 1 [3.0] 2 [1.5] Myometrium, Hyperplasia 1 [3.0] Vagina (2) (3) Inflammation, Suppurative 1 [4.0] Muscularis, Hypertrophy 1 [4.0] ____________________________________________________________________________________________________________________________________ HEMATOPOIETIC SYSTEM Bone Marrow (50) (50) (50) (50) Myelofibrosis 1 [3.0] Lymph Node (6) (10) (9) (8) Deep Cervical, Infiltration Cellular, Histiocyte 3 [3.3] 1 [2.0] Pancreatic, Pigmentation 1 [4.0] 1 [4.0] Lymph Node, Bronchial (8) (9) (5) (14) Infiltration Cellular, Histiocyte 1 [3.0] Lymph Node, Mesenteric (50) (50) (50) (50) Infiltration Cellular, Histiocyte 2 [2.5] 1 [3.0] 2 [3.5] Pigmentation 1 [4.0] Lymph Node, Mediastinal (32) (37) (44) (34) Fibrosis 1 [3.0] Hyperplasia, Lymphoid 1 [4.0] 1 [3.0] Infiltration Cellular, Histiocyte 2 [3.0] 1 [3.0] Inflammation, Suppurative 1 [3.0] Spleen (50) (50) (50) (50) Accessory Spleen 2 1 1 Fibrosis 3 [3.0] 1 [4.0] 3 [3.3] 1 [2.0] Hematopoietic Cell Proliferation 1 [4.0] Hemorrhage 2 [3.5] 1 [4.0] 1 [4.0] 2 [4.0] Hyperplasia, Focal, Lymphoid 2 [3.5] Inflammation, Chronic Active 1 [3.0] Necrosis 1 [4.0] a Number of animals examined microscopically at site and number of animals with lesion b Average severity grade (1-minimal;2-mild;3-moderate;4-marked) Page 4 NTP Experiment-Test: 88004-05 INCIDENCE RATES OF NONNEOPLASTIC LESIONS BY ANATOMIC SITE (a) Report: PEIRPT18 Study Type: CHRONIC WITH AVERAGE SEVERITY GRADES[b] Date: 12/17/03 Route: RESPIRATORY EXPOSURE WHOLE BODY DIVINYLBENZENE Time: 12:01:01 ____________________________________________________________________________________________________________________________________ FISCHER 344 RATS FEMALE CONTROL 100 PPM 200 PPM 400 PPM ____________________________________________________________________________________________________________________________________ HEMATOPOIETIC SYSTEM - CONT Thymus (45) (41) (46) (39) Cyst 1 [4.0] ____________________________________________________________________________________________________________________________________ INTEGUMENTARY SYSTEM Mammary Gland (50) (50) (50) (50) Galactocele 1 [1.0] 2 [2.0] Hyperplasia 1 [3.0] Inflammation, Chronic 1 [3.0] Skin (50) (50) (50) (50) Cyst Epithelial Inclusion 2 [4.0] 1 [4.0] Hyperkeratosis 1 [3.0] Inflammation, Granulomatous 1 [4.0] Ulcer 1 [4.0] 1 [4.0] ____________________________________________________________________________________________________________________________________ MUSCULOSKELETAL SYSTEM Bone (50) (50) (50) (50) Joint, Fracture 1 [4.0] Tibia, Fracture 1 [4.0] Skeletal Muscle (2) (3) (7) (5) Inflammation, Chronic 1 [4.0] Necrosis 1 [4.0] 1 [3.0] ____________________________________________________________________________________________________________________________________ NERVOUS SYSTEM Brain (50) (50) (50) (50) Compression 9 [3.1] 10 [3.1] 11 [2.9] 7 [3.1] Congestion 1 [1.0] Hemorrhage 2 [1.0] 2 [4.0] 6 [2.8] 3 [3.7] Infarct 1 [2.0] ____________________________________________________________________________________________________________________________________ RESPIRATORY SYSTEM Larynx (50) (50) (49) (50) Foreign Body 1 [4.0] 3 [4.0] Inflammation, Suppurative 2 [2.0] 1 [2.0] Epiglottis, Metaplasia, Squamous 1 [2.0] Lung (50) (50) (50) (50) a Number of animals examined microscopically at site and number of animals with lesion b Average severity grade (1-minimal;2-mild;3-moderate;4-marked) Page 5 NTP Experiment-Test: 88004-05 INCIDENCE RATES OF NONNEOPLASTIC LESIONS BY ANATOMIC SITE (a) Report: PEIRPT18 Study Type: CHRONIC WITH AVERAGE SEVERITY GRADES[b] Date: 12/17/03 Route: RESPIRATORY EXPOSURE WHOLE BODY DIVINYLBENZENE Time: 12:01:01 ____________________________________________________________________________________________________________________________________ FISCHER 344 RATS FEMALE CONTROL 100 PPM 200 PPM 400 PPM ____________________________________________________________________________________________________________________________________ RESPIRATORY SYSTEM - CONT Atrophy 1 [4.0] Cyst 1 [4.0] Foreign Body 1 [2.0] Hemorrhage 1 [2.0] 1 [1.0] 1 [2.0] 1 [3.0] Infiltration Cellular, Histiocyte 1 [4.0] Inflammation, Chronic 1 [2.0] Inflammation, Chronic, Diffuse 1 [3.0] 1 [2.0] Inflammation, Chronic, Focal 27 [1.3] 22 [1.4] 26 [1.3] 33 [1.2] Alveolar Epithelium, Hyperplasia 4 [2.3] 2 [1.5] 3 [1.7] 1 [3.0] Alveolar Epithelium, Hypertrophy 1 [1.0] 1 [1.0] 1 [2.0] Alveolus, Infiltration Cellular, Focal, Histiocyte 8 [1.1] 3 [1.3] 6 [1.3] 5 [1.2] Interstitium, Fibrosis 1 [1.0] Mediastinum, Necrosis, Fatty 1 [4.0] Nose (50) (50) (49) (49) Foreign Body 1 [3.0] 5 [2.0] 1 [3.0] Inflammation, Suppurative 5 [2.4] 12 [1.7] 8 [1.3] 7 [1.6] Ulcer 1 [4.0] Glands, Dilatation 17 [1.3] 38 [1.3] 44 [1.7] Goblet Cell, Hyperplasia 1 [2.0] 3 [1.7] 1 [1.0] 4 [1.5] Nasolacrimal Duct, Inflammation, Suppurative 3 [2.0] 1 [3.0] 3 [2.3] 1 [2.0] Nasopharyngeal Duct, Inflammation, Suppurative 1 [3.0] Olfactory Epithelium, Degeneration 50 [1.5] 49 [1.8] 48 [2.0] Olfactory Epithelium, Degeneration, Hyaline 10 [1.5] 14 [1.1] 15 [1.1] 4 [1.0] Olfactory Epithelium, Hyperplasia, Basal Cell 25 [1.0] 42 [1.3] 45 [1.8] Olfactory Epithelium, Regeneration, Focal 1 [1.0] Respiratory Epithelium, Degeneration, Hyaline 5 [1.8] 3 [2.0] 4 [1.3] Respiratory Epithelium, Hyperplasia 1 [2.0] 1 [3.0] Respiratory Epithelium, Metaplasia, Squamous 1 [2.0] Pleura (50) (50) (50) (49) Fibrosis 1 [2.0] Infiltration Cellular, Lymphoid 1 [4.0] Trachea (50) (50) (50) (50) Glands, Degeneration, Cystic 1 [1.0] 1 [2.0] ____________________________________________________________________________________________________________________________________ SPECIAL SENSES SYSTEM Eye (50) (48) (49) (49) Atrophy 1 [4.0] Inflammation, Chronic 1 [1.0] Anterior Chamber, Hemorrhage 1 [4.0] a Number of animals examined microscopically at site and number of animals with lesion b Average severity grade (1-minimal;2-mild;3-moderate;4-marked) Page 6 NTP Experiment-Test: 88004-05 INCIDENCE RATES OF NONNEOPLASTIC LESIONS BY ANATOMIC SITE (a) Report: PEIRPT18 Study Type: CHRONIC WITH AVERAGE SEVERITY GRADES[b] Date: 12/17/03 Route: RESPIRATORY EXPOSURE WHOLE BODY DIVINYLBENZENE Time: 12:01:01 ____________________________________________________________________________________________________________________________________ FISCHER 344 RATS FEMALE CONTROL 100 PPM 200 PPM 400 PPM ____________________________________________________________________________________________________________________________________ SPECIAL SENSES SYSTEM - CONT Ciliary Body, Inflammation 1 [2.0] Cornea, Inflammation 1 [2.0] Lens, Cataract 1 [4.0] 3 [2.7] 4 [3.8] 1 [4.0] Harderian Gland (50) (50) (50) (50) Inflammation, Suppurative 1 [4.0] ____________________________________________________________________________________________________________________________________ URINARY SYSTEM Kidney (50) (50) (49) (50) Cyst 1 [4.0] Nephropathy, Chronic 19 [1.4] 21 [1.3] 19 [1.7] 10 [2.2] Bilateral, Cortex, Renal Tubule, Degeneration 1 [4.0] Cortex, Infarct 2 [2.0] Cortex, Renal Tubule, Accumulation, Hyaline Droplet 1 [4.0] Cortex, Renal Tubule, Hyperplasia 1 [3.0] 1 [1.0] Medulla, Renal Tubule, Degeneration 1 [3.0] Pelvis, Transitional Epithelium, Hyperplasia 1 [2.0] 1 [2.0] Pelvis, Transitional Epithelium, Mineralization 1 [2.0] Renal Tubule, Dilatation 1 [4.0] Urinary Bladder (50) (50) (49) (49) Transitional Epithelium, Hyperplasia 1 [4.0] a Number of animals examined microscopically at site and number of animals with lesion b Average severity grade (1-minimal;2-mild;3-moderate;4-marked) Page 7 NTP Experiment-Test: 88004-05 INCIDENCE RATES OF NONNEOPLASTIC LESIONS BY ANATOMIC SITE (a) Report: PEIRPT18 Study Type: CHRONIC WITH AVERAGE SEVERITY GRADES[b] Date: 12/17/03 Route: RESPIRATORY EXPOSURE WHOLE BODY DIVINYLBENZENE Time: 12:01:01 ____________________________________________________________________________________________________________________________________ FISCHER 344 RATS MALE CONTROL 100 PPM 200 PPM 400 PPM ____________________________________________________________________________________________________________________________________ DISPOSITION SUMMARY Animals Initially In Study 50 50 50 50 Early Deaths Moribund Sacrifice 15 9 12 13 Natural Death 4 6 6 5 Survivors Terminal Sacrifice 31 35 31 32 Natural Death 1 Animals Examined Microscopically 50 50 50 50 ____________________________________________________________________________________________________________________________________ ALIMENTARY SYSTEM Esophagus (50) (50) (50) (50) Foreign Body 1 Intestine Small, Jejunum (46) (47) (47) (46) Necrosis 1 [3.0] Intestine Small, Ileum (46) (47) (45) (46) Dilatation 1 [4.0] Liver (50) (49) (50) (50) Angiectasis 1 [4.0] 1 [3.0] Clear Cell Focus 2 [1.0] 5 [2.5] 1 [4.0] 1 [4.0] Hemorrhage 1 [3.0] Hepatodiaphragmatic Nodule 2 [4.0] 2 [4.0] 4 [4.0] 8 [4.0] Inflammation, Granulomatous 1 [3.0] Necrosis 1 [4.0] 1 [2.0] 3 [2.3] 2 [3.5] Vacuolization Cytoplasmic 1 [3.0] 2 [2.0] 3 [2.7] 3 [2.3] Bile Duct, Hyperplasia 3 [2.0] Hepatocyte, Regeneration 1 [4.0] Periportal, Inflammation, Chronic 2 [2.0] Serosa, Fibrosis 1 [4.0] 1 [4.0] Serosa, Hemorrhage 1 [4.0] Mesentery (12) (13) (18) (11) Necrosis 7 [2.9] 13 [2.9] 18 [2.9] 9 [3.0] Fat, Hemorrhage 1 [4.0] Oral Mucosa (1) (1) (4) Gingival, Cyst 1 [4.0] Gingival, Hyperplasia, Squamous 1 [1.0] Pancreas (50) (49) (50) (50) Thrombosis 1 [4.0] Acinus, Atrophy 15 [1.8] 18 [1.8] 27 [1.7] 21 [2.0] Acinus, Hyperplasia 1 [3.0] a Number of animals examined microscopically at site and number of animals with lesion b Average severity grade (1-minimal;2-mild;3-moderate;4-marked) Page 8 NTP Experiment-Test: 88004-05 INCIDENCE RATES OF NONNEOPLASTIC LESIONS BY ANATOMIC SITE (a) Report: PEIRPT18 Study Type: CHRONIC WITH AVERAGE SEVERITY GRADES[b] Date: 12/17/03 Route: RESPIRATORY EXPOSURE WHOLE BODY DIVINYLBENZENE Time: 12:01:01 ____________________________________________________________________________________________________________________________________ FISCHER 344 RATS MALE CONTROL 100 PPM 200 PPM 400 PPM ____________________________________________________________________________________________________________________________________ ALIMENTARY SYSTEM - CONT Acinus, Inflammation 1 [2.0] Duct, Cyst 1 [1.0] 2 [2.5] 3 [3.0] Stomach, Forestomach (50) (48) (50) (50) Diverticulum 1 [3.0] Hyperplasia, Squamous 1 [2.0] Inflammation, Suppurative 1 [1.0] Ulcer 4 [3.0] 1 [4.0] 1 [4.0] Stomach, Glandular (50) (48) (50) (49) Erosion 2 [2.5] 2 [2.5] 2 [2.5] Ulcer 1 [4.0] 2 [4.0] 1 [3.0] Epithelium, Hyperplasia 1 [2.0] Tongue (1) (1) Epithelium, Hyperplasia 1 [3.0] ____________________________________________________________________________________________________________________________________ CARDIOVASCULAR SYSTEM Blood Vessel (50) (50) (50) (50) Thrombosis 1 [3.0] Heart (50) (50) (50) (50) Cardiomyopathy 7 [1.6] 5 [2.2] 1 [2.0] 1 [2.0] Atrium, Thrombosis 2 [3.5] 1 [4.0] 2 [4.0] 1 [4.0] Pericardium, Inflammation 1 [3.0] Pericardium, Pigmentation 1 [4.0] Pericardium, Epicardium, Infiltration Cellular, Histiocyte 1 [4.0] ____________________________________________________________________________________________________________________________________ ENDOCRINE SYSTEM Adrenal Cortex (50) (50) (50) (50) Hyperplasia 1 [3.0] 2 [1.5] Necrosis 2 [2.5] Vacuolization Cytoplasmic 8 [2.1] 8 [1.8] 7 [1.7] 6 [1.8] Adrenal Medulla (50) (50) (50) (50) Hyperplasia 12 [3.2] 13 [2.7] 8 [2.4] 14 [2.3] Bilateral, Hyperplasia 1 [4.0] Islets, Pancreatic (50) (48) (50) (50) Hyperplasia 1 [1.0] 1 [1.0] 2 [2.0] 2 [3.0] Parathyroid Gland (46) (48) (49) (47) Hyperplasia 1 [2.0] 1 [3.0] Pituitary Gland (50) (50) (50) (49) Cyst 1 [2.0] 1 [4.0] 1 [4.0] 1 [3.0] a Number of animals examined microscopically at site and number of animals with lesion b Average severity grade (1-minimal;2-mild;3-moderate;4-marked) Page 9 NTP Experiment-Test: 88004-05 INCIDENCE RATES OF NONNEOPLASTIC LESIONS BY ANATOMIC SITE (a) Report: PEIRPT18 Study Type: CHRONIC WITH AVERAGE SEVERITY GRADES[b] Date: 12/17/03 Route: RESPIRATORY EXPOSURE WHOLE BODY DIVINYLBENZENE Time: 12:01:01 ____________________________________________________________________________________________________________________________________ FISCHER 344 RATS MALE CONTROL 100 PPM 200 PPM 400 PPM ____________________________________________________________________________________________________________________________________ ENDOCRINE SYSTEM - CONT Hemorrhage 1 [3.0] 1 [3.0] Pars Distalis, Hematocyst 1 [4.0] Pars Distalis, Hyperplasia 5 [2.2] 8 [2.3] 9 [2.6] 8 [2.8] Thyroid Gland (50) (50) (50) (49) C-Cell, Hyperplasia 2 [2.5] 4 [3.0] 9 [2.6] 7 [2.4] Follicular Cell, Hyperplasia 2 [2.0] 2 [2.5] 1 [1.0] ____________________________________________________________________________________________________________________________________ GENERAL BODY SYSTEM None ____________________________________________________________________________________________________________________________________ GENITAL SYSTEM Penis (2) Inflammation 1 [4.0] Preputial Gland (48) (50) (50) (49) Cyst 1 [3.0] 1 [4.0] 2 [4.0] 1 [4.0] Hyperplasia 1 [4.0] 4 [3.8] 1 [4.0] 1 [4.0] Prostate (50) (50) (50) (50) Hyperplasia 1 [1.0] Inflammation, Suppurative 5 [2.0] 1 [2.0] 4 [3.5] 2 [1.5] Seminal Vesicle (50) (49) (50) (50) Dilatation 1 [4.0] Hyperplasia 1 [3.0] Inflammation, Suppurative 1 [3.0] Testes (50) (50) (50) (50) Artery, Inflammation, Chronic Active 2 [3.0] Germinal Epithelium, Atrophy 16 [3.9] 12 [3.1] 11 [3.3] 9 [3.4] Interstitial Cell, Hyperplasia 7 [3.0] 6 [2.8] 2 [2.5] 3 [2.7] ____________________________________________________________________________________________________________________________________ HEMATOPOIETIC SYSTEM Lymph Node (11) (5) (11) (6) Deep Cervical, Angiectasis 1 [4.0] 1 [2.0] Deep Cervical, Cyst 1 [2.0] Deep Cervical, Hemorrhage 1 [3.0] Deep Cervical, Hyperplasia, Lymphoid 1 [3.0] Pancreatic, Ectasia 1 [3.0] Pancreatic, Hemorrhage 1 [3.0] Pancreatic, Infiltration Cellular, Histiocyte 1 [3.0] a Number of animals examined microscopically at site and number of animals with lesion b Average severity grade (1-minimal;2-mild;3-moderate;4-marked) Page 10 NTP Experiment-Test: 88004-05 INCIDENCE RATES OF NONNEOPLASTIC LESIONS BY ANATOMIC SITE (a) Report: PEIRPT18 Study Type: CHRONIC WITH AVERAGE SEVERITY GRADES[b] Date: 12/17/03 Route: RESPIRATORY EXPOSURE WHOLE BODY DIVINYLBENZENE Time: 12:01:01 ____________________________________________________________________________________________________________________________________ FISCHER 344 RATS MALE CONTROL 100 PPM 200 PPM 400 PPM ____________________________________________________________________________________________________________________________________ HEMATOPOIETIC SYSTEM - CONT Lymph Node, Bronchial (7) (6) (12) (5) Hemorrhage 1 [3.0] Infiltration Cellular 1 [3.0] Pigmentation 1 [3.0] Lymph Node, Mesenteric (49) (49) (50) (50) Angiectasis 1 [4.0] Ectasia 1 [4.0] Hemorrhage 1 [3.0] Hyperplasia, Lymphoid 1 [4.0] Infiltration Cellular, Histiocyte 1 [1.0] 1 [4.0] 3 [3.3] Lymph Node, Mediastinal (19) (23) (25) (38) Angiectasis 1 [4.0] Hyperplasia, Lymphoid 1 [3.0] Spleen (50) (49) (50) (50) Accessory Spleen 3 1 Fibrosis 2 [3.5] 6 [3.2] 4 [3.3] 1 [4.0] Hematopoietic Cell Proliferation 1 [4.0] Hemorrhage 2 [4.0] 1 [4.0] 1 [4.0] Hyperplasia, Focal, Lymphoid 1 [3.0] Necrosis 3 [4.0] 1 [4.0] 1 [4.0] 1 [4.0] Lymphocyte, Hyperplasia, Diffuse 1 [2.0] Thymus (48) (44) (46) (42) Hemorrhage 1 [3.0] ____________________________________________________________________________________________________________________________________ INTEGUMENTARY SYSTEM Mammary Gland (35) (43) (47) (48) Galactocele 3 [3.7] 2 [1.5] 6 [4.0] 3 [4.0] Skin (50) (50) (50) (50) Cyst Epithelial Inclusion 4 [4.0] 1 [4.0] 3 [4.0] 2 [4.0] Hyperkeratosis 2 [3.5] 1 [3.0] 2 [3.5] Inflammation, Acute 2 [4.0] Inflammation, Granulomatous 1 [4.0] Ulcer 2 [3.5] Subcutaneous Tissue, Thrombosis 1 [4.0] ____________________________________________________________________________________________________________________________________ MUSCULOSKELETAL SYSTEM Bone (50) (50) (50) (50) Hyperostosis 1 [3.0] Cartilage, Femur, Hyperplasia 1 [1.0] a Number of animals examined microscopically at site and number of animals with lesion b Average severity grade (1-minimal;2-mild;3-moderate;4-marked) Page 11 NTP Experiment-Test: 88004-05 INCIDENCE RATES OF NONNEOPLASTIC LESIONS BY ANATOMIC SITE (a) Report: PEIRPT18 Study Type: CHRONIC WITH AVERAGE SEVERITY GRADES[b] Date: 12/17/03 Route: RESPIRATORY EXPOSURE WHOLE BODY DIVINYLBENZENE Time: 12:01:01 ____________________________________________________________________________________________________________________________________ FISCHER 344 RATS MALE CONTROL 100 PPM 200 PPM 400 PPM ____________________________________________________________________________________________________________________________________ MUSCULOSKELETAL SYSTEM - CONT Femur, Fracture 1 [4.0] ____________________________________________________________________________________________________________________________________ NERVOUS SYSTEM Brain (49) (50) (50) (50) Compression 10 [2.9] 5 [2.4] 8 [2.9] 6 [3.5] Gliosis 1 [3.0] Hemorrhage 1 [4.0] 1 [3.0] ____________________________________________________________________________________________________________________________________ RESPIRATORY SYSTEM Larynx (49) (49) (50) (49) Foreign Body 1 [4.0] 2 [4.0] 3 [4.0] 2 [2.5] Inflammation, Suppurative 1 [2.0] 1 [4.0] 1 [1.0] Epiglottis, Metaplasia, Squamous 1 [3.0] 1 [2.0] Lung (50) (50) (50) (50) Congestion 1 [2.0] Hemorrhage 2 [3.0] 1 [2.0] 4 [1.8] 4 [1.5] Inflammation, Chronic 1 [3.0] Inflammation, Chronic, Diffuse 1 [2.0] Inflammation, Chronic, Focal 4 [1.0] 4 [1.5] 5 [1.6] 14 [1.1] Inflammation, Suppurative 1 [1.0] Necrosis 1 [2.0] 1 [4.0] Thrombosis 1 [4.0] Alveolar Epithelium, Hyperplasia 4 [2.5] 8 [1.8] 6 [1.7] 6 [3.2] Alveolar Epithelium, Hypertrophy 1 [1.0] 1 [1.0] 2 [1.0] Alveolus, Hypertrophy 1 [1.0] Alveolus, Infiltration Cellular, Focal, Histiocyte 9 [1.6] 12 [1.6] 11 [1.5] 4 [1.5] Interstitium, Fibrosis 1 [2.0] 1 [1.0] 1 [1.0] 1 [1.0] Mediastinum, Abscess 1 [3.0] Mediastinum, Inflammation, Chronic 1 [2.0] Mediastinum, Pigmentation 1 [4.0] Perivascular, Edema 1 [1.0] Perivascular, Infiltration Cellular, Eosinophil 1 [1.0] Nose (50) (48) (50) (49) Foreign Body 5 [2.0] 1 [3.0] 3 [1.7] Inflammation, Suppurative 5 [2.4] 9 [1.4] 17 [1.7] 10 [1.6] Glands, Dilatation 3 [1.7] 30 [1.2] 48 [1.5] 46 [1.5] Goblet Cell, Hyperplasia 1 [2.0] 3 [1.7] 7 [1.7] 16 [1.6] a Number of animals examined microscopically at site and number of animals with lesion b Average severity grade (1-minimal;2-mild;3-moderate;4-marked) Page 12 NTP Experiment-Test: 88004-05 INCIDENCE RATES OF NONNEOPLASTIC LESIONS BY ANATOMIC SITE (a) Report: PEIRPT18 Study Type: CHRONIC WITH AVERAGE SEVERITY GRADES[b] Date: 12/17/03 Route: RESPIRATORY EXPOSURE WHOLE BODY DIVINYLBENZENE Time: 12:01:01 ____________________________________________________________________________________________________________________________________ FISCHER 344 RATS MALE CONTROL 100 PPM 200 PPM 400 PPM ____________________________________________________________________________________________________________________________________ RESPIRATORY SYSTEM - CONT Nasolacrimal Duct, Inflammation, Suppurative 2 [1.0] 6 [1.7] 1 [1.0] 4 [2.3] Nasopharyngeal Duct, Cyst 1 [4.0] Nasopharyngeal Duct, Foreign Body 1 [1.0] Nasopharyngeal Duct, Inflammation, Suppurative 1 [2.0] Nasopharyngeal Duct, Respiratory Epithelium, Hyperplasia 1 [4.0] Olfactory Epithelium, Degeneration 47 [1.6] 49 [1.7] 49 [2.0] Olfactory Epithelium, Degeneration, Hyaline 4 [1.3] 2 [1.0] 1 [2.0] Olfactory Epithelium, Hyperplasia, Basal Cell 21 [1.0] 44 [1.4] 48 [1.7] Olfactory Epithelium, Metaplasia 1 [1.0] 2 [1.5] Respiratory Epithelium, Hyperplasia 1 [3.0] Turbinate, Cyst 1 [2.0] Pleura (50) (50) (50) (50) Mesothelium, Hyperplasia 1 [2.0] Trachea (50) (49) (50) (49) Glands, Degeneration, Cystic 1 [2.0] 5 [1.6] ____________________________________________________________________________________________________________________________________ SPECIAL SENSES SYSTEM Eye (50) (48) (48) (49) Anterior Chamber, Hemorrhage 1 [4.0] Cornea, Mineralization 1 [1.0] Lens, Cataract 2 [2.0] 1 [4.0] 3 [3.0] 1 [2.0] Retina, Atrophy 1 [4.0] Harderian Gland (50) (50) (50) (50) Atrophy 1 [4.0] Zymbal's Gland (1) (3) Inflammation, Suppurative 1 [4.0] ____________________________________________________________________________________________________________________________________ URINARY SYSTEM Kidney (50) (49) (50) (49) Cyst 1 [4.0] 1 [4.0] Nephropathy, Chronic 37 [1.8] 41 [1.5] 41 [2.1] 45 [1.8] Cortex, Infarct 1 [4.0] 1 [2.0] Cortex, Renal Tubule, Degeneration 1 [2.0] Cortex, Renal Tubule, Hyperplasia 1 [2.0] 2 [1.0] 2 [4.0] Cortex, Renal Tubule, Hypertrophy 1 [1.0] Medulla, Infarct 1 [4.0] Medulla, Infiltration Cellular, Lipocyte 1 [3.0] a Number of animals examined microscopically at site and number of animals with lesion b Average severity grade (1-minimal;2-mild;3-moderate;4-marked) Page 13 NTP Experiment-Test: 88004-05 INCIDENCE RATES OF NONNEOPLASTIC LESIONS BY ANATOMIC SITE (a) Report: PEIRPT18 Study Type: CHRONIC WITH AVERAGE SEVERITY GRADES[b] Date: 12/17/03 Route: RESPIRATORY EXPOSURE WHOLE BODY DIVINYLBENZENE Time: 12:01:01 ____________________________________________________________________________________________________________________________________ FISCHER 344 RATS MALE CONTROL 100 PPM 200 PPM 400 PPM ____________________________________________________________________________________________________________________________________ URINARY SYSTEM - CONT Papilla, Renal Tubule, Dilatation 1 [4.0] Pelvis, Transitional Epithelium, Hyperplasia 1 [4.0] 1 [2.0] Pelvis, Transitional Epithelium, Mineralization 1 [3.0] Urethra (1) Transitional Epithelium, Hyperplasia 1 [3.0] Urinary Bladder (50) (49) (50) (49) Calculus Micro Observation Only 4 [2.0] 2 [2.5] 4 [3.3] 4 [2.0] Hemorrhage 2 [3.0] 1 [4.0] 1 [3.0] Transitional Epithelium, Hyperplasia 1 [2.0] a Number of animals examined microscopically at site and number of animals with lesion b Average severity grade (1-minimal;2-mild;3-moderate;4-marked) Page 14 ------------------------------------------------------------ ---------- END OF REPORT ---------- ------------------------------------------------------------