TDMS Study 93020-06 Pathology Tables
NTP Experiment-Test: 93020-06 INCIDENCE RATES OF NEOPLASMS BY ANATOMIC SITE (a) Report: PEIRPT02 Study Type: SUBCHRON 26-WEEK DIISOPROPYLCARBODIIMIDE (DIC) Date: 01/10/01 Route: SKIN APPLICATION Time: 08:32:09 Final #1/Mice Facility: BIORELIANCE Chemical CAS #: 693-13-0 Lock Date: 02/24/00 Cage Range: All Reasons For Removal: All Removal Date Range: All Treatment Groups: Include All a Number of animals examined microscopically at site and number of animals with lesion Page 1 NTP Experiment-Test: 93020-06 INCIDENCE RATES OF NEOPLASMS BY ANATOMIC SITE (a) Report: PEIRPT02 Study Type: SUBCHRON 26-WEEK DIISOPROPYLCARBODIIMIDE (DIC) Date: 01/10/01 Route: SKIN APPLICATION Time: 08:32:09 ____________________________________________________________________________________________________________________________________ MICE:P53+/-(C57BL/6) FEMALE VEHICLE 4.38 8.75 17.5 35 MG/KG 70 MG/KG CONTROL MG/KG MG/KG MG/KG ____________________________________________________________________________________________________________________________________ DISPOSITION SUMMARY Animals Initially in Study 15 15 15 15 15 15 Early Deaths Survivors Terminal Sacrifice 15 15 15 15 15 15 Animals Examined Microscopically 15 15 15 15 15 15 ____________________________________________________________________________________________________________________________________ ALIMENTARY SYSTEM None ____________________________________________________________________________________________________________________________________ CARDIOVASCULAR SYSTEM None ____________________________________________________________________________________________________________________________________ ENDOCRINE SYSTEM None ____________________________________________________________________________________________________________________________________ GENERAL BODY SYSTEM None ____________________________________________________________________________________________________________________________________ GENITAL SYSTEM None ____________________________________________________________________________________________________________________________________ HEMATOPOIETIC SYSTEM Lymph Node, Mandibular (15) (15) (15) (14) (15) (15) Page 2 NTP Experiment-Test: 93020-06 INCIDENCE RATES OF NEOPLASMS BY ANATOMIC SITE (a) Report: PEIRPT02 Study Type: SUBCHRON 26-WEEK DIISOPROPYLCARBODIIMIDE (DIC) Date: 01/10/01 Route: SKIN APPLICATION Time: 08:32:09 ____________________________________________________________________________________________________________________________________ MICE:P53+/-(C57BL/6) FEMALE VEHICLE 4.38 8.75 17.5 35 MG/KG 70 MG/KG CONTROL MG/KG MG/KG MG/KG ____________________________________________________________________________________________________________________________________ HEMATOPOIETIC SYSTEM - cont Hemangioma 1 (7%) ____________________________________________________________________________________________________________________________________ INTEGUMENTARY SYSTEM None ____________________________________________________________________________________________________________________________________ MUSCULOSKELETAL SYSTEM None ____________________________________________________________________________________________________________________________________ NERVOUS SYSTEM None ____________________________________________________________________________________________________________________________________ RESPIRATORY SYSTEM None ____________________________________________________________________________________________________________________________________ SPECIAL SENSES SYSTEM None ____________________________________________________________________________________________________________________________________ URINARY SYSTEM None Page 3 NTP Experiment-Test: 93020-06 INCIDENCE RATES OF NEOPLASMS BY ANATOMIC SITE (a) Report: PEIRPT02 Study Type: SUBCHRON 26-WEEK DIISOPROPYLCARBODIIMIDE (DIC) Date: 01/10/01 Route: SKIN APPLICATION Time: 08:32:09 ____________________________________________________________________________________________________________________________________ MICE:P53+/-(C57BL/6) FEMALE VEHICLE 4.38 8.75 17.5 35 MG/KG 70 MG/KG CONTROL MG/KG MG/KG MG/KG ____________________________________________________________________________________________________________________________________ TUMOR SUMMARY Total Animals with Primary Neoplasms (b) 1 Total Primary Neoplasms 1 Total Animals with Benign Neoplasms 1 Total Benign Neoplasms 1 Total Animals with Malignant Neoplasms Total Malignant Neoplasms Total Animals with Metastatic Neoplasms Total Metastatic Neoplasm Total Animals with Malignant Neoplasms Uncertain Primary Site Total Animals with Neoplasms Uncertain- Benign or Malignant Total Uncertain Neoplasms ____________________________________________________________________________________________________________________________________ a Number of animals examined microscopically at site and number of animals with lesion b Primary tumors: all tumors except metastatic tumors Page 4 ------------------------------------------------------------ ---------- END OF REPORT ---------- ------------------------------------------------------------