TDMS Study 93020-06 Pathology Tables
NTP Experiment-Test: 93020-06 INCIDENCE RATES OF NONNEOPLASTIC LESIONS BY ANATOMIC SITE (a) Report: PEIRPT03
Study Type: SUBCHRON 26-WEEK DIISOPROPYLCARBODIIMIDE (DIC) Date: 01/10/01
Route: SKIN APPLICATION Time: 11:03:02
Final#1/Mice
Facility: BIORELIANCE
Chemical CAS #: 693-13-0
Lock Date: 02/24/00
Cage Range: All
Reasons For Removal: All
Removal Date Range: All
Treatment Groups: Include All
a Number of animals examined microscopically at site and number of animals with lesion
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NTP Experiment-Test: 93020-06 INCIDENCE RATES OF NONNEOPLASTIC LESIONS BY ANATOMIC SITE (a) Report: PEIRPT03
Study Type: SUBCHRON 26-WEEK DIISOPROPYLCARBODIIMIDE (DIC) Date: 01/10/01
Route: SKIN APPLICATION Time: 11:03:02
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MICE:P53+/-(C57BL/6) FEMALE VEHICLE 4.38 8.75 17.5 35 MG/KG 70 MG/KG
CONTROL MG/KG MG/KG MG/KG
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DISPOSITION SUMMARY
Animals Initially In Study 15 15 15 15 15 15
Early Deaths
Survivors
Terminal Sacrifice 15 15 15 15 15 15
Animals Examined Microscopically 15 15 15 15 15 15
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ALIMENTARY SYSTEM
Liver (15) (15) (15) (15) (15) (15)
Infiltration Cellular, Focal, Lymphocyte 4 (27%) 1 (7%) 1 (7%) 2 (13%) 5 (33%)
Infiltration Cellular, Lymphocyte 1 (7%)
Inflammation, Chronic Active, Focal 1 (7%)
Hepatocyte, Necrosis, Focal 1 (7%) 1 (7%) 3 (20%) 8 (53%) 4 (27%) 3 (20%)
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CARDIOVASCULAR SYSTEM
None
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ENDOCRINE SYSTEM
Adrenal Cortex (15) (15) (15) (14) (14) (15)
Subcapsular, Hyperplasia, Focal 12 (80%) 7 (47%) 10 (67%) 12 (86%) 12 (86%) 15 (100%)
Zona Glomerulosa, Hyperplasia, Focal 1 (7%)
Parathyroid Gland (10) (5) (4) (4) (9) (5)
Cyst 1 (20%)
Thyroid Gland (15) (14) (14) (15) (15) (15)
Ectopic Thymus 2 (13%) 1 (7%) 2 (13%) 1 (7%) 1 (7%)
Follicular Cell, Hyperplasia, Focal 1 (7%)
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GENERAL BODY SYSTEM
None
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GENITAL SYSTEM
Uterus (15) (15) (15) (15) (15) (15)
a Number of animals examined microscopically at site and number of animals with lesion
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NTP Experiment-Test: 93020-06 INCIDENCE RATES OF NONNEOPLASTIC LESIONS BY ANATOMIC SITE (a) Report: PEIRPT03
Study Type: SUBCHRON 26-WEEK DIISOPROPYLCARBODIIMIDE (DIC) Date: 01/10/01
Route: SKIN APPLICATION Time: 11:03:02
____________________________________________________________________________________________________________________________________
MICE:P53+/-(C57BL/6) FEMALE VEHICLE 4.38 8.75 17.5 35 MG/KG 70 MG/KG
CONTROL MG/KG MG/KG MG/KG
____________________________________________________________________________________________________________________________________
GENITAL SYSTEM - CONT
Hydrometra 1 (7%)
Endometrium, Hyperplasia, Cystic 14 (93%) 14 (93%) 14 (93%) 14 (93%) 14 (93%) 13 (87%)
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HEMATOPOIETIC SYSTEM
Bone Marrow (1) (1)
Myeloid Cell, Hyperplasia 1 (100%)
Lymph Node (1)
Inguinal, Hyperplasia, Lymphoid 1 (100%)
Lymph Node, Mandibular (15) (15) (15) (14) (15) (15)
Hyperplasia, Lymphoid 2 (13%) 2 (13%) 1 (7%)
Lymph Node, Mediastinal (15) (14) (13) (15) (12) (15)
Hyperplasia, Lymphoid 2 (13%)
Spleen (15) (15) (15) (15) (15) (15)
Hematopoietic Cell Proliferation 14 (93%) 15 (100%) 15 (100%) 15 (100%) 14 (93%) 15 (100%)
Pigmentation 1 (7%)
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INTEGUMENTARY SYSTEM
Skin (15) (15) (15) (15) (15) (15)
Dermis, Fibrosis 1 (7%)
Dermis, Infiltration Cellular, Mast Cell 2 (13%)
Epidermis, Control, Hyperplasia, Focal 1 (7%)
Epidermis, Skin, Site of Application,
Hyperplasia 8 (53%)
Epidermis, Skin, Site of Application,
Hyperplasia, Diffuse 1 (7%)
Epidermis, Skin, Site of Application,
Hyperplasia, Focal 1 (7%)
Sebaceous Gland, Hypertrophy 1 (7%)
Subcutaneous Tissue, Metaplasia, Focal,
Osseous 1 (7%)
Vulva, Degeneration 1 (7%)
Vulva, Ulcer, Chronic, Focal 1 (7%)
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MUSCULOSKELETAL SYSTEM
None
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a Number of animals examined microscopically at site and number of animals with lesion
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NTP Experiment-Test: 93020-06 INCIDENCE RATES OF NONNEOPLASTIC LESIONS BY ANATOMIC SITE (a) Report: PEIRPT03
Study Type: SUBCHRON 26-WEEK DIISOPROPYLCARBODIIMIDE (DIC) Date: 01/10/01
Route: SKIN APPLICATION Time: 11:03:02
____________________________________________________________________________________________________________________________________
MICE:P53+/-(C57BL/6) FEMALE VEHICLE 4.38 8.75 17.5 35 MG/KG 70 MG/KG
CONTROL MG/KG MG/KG MG/KG
____________________________________________________________________________________________________________________________________
NERVOUS SYSTEM
None
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RESPIRATORY SYSTEM
Lung (15) (15) (15) (15) (15) (15)
Alveolus, Hemorrhage, Focal 1 (7%) 1 (7%)
Alveolus, Inflammation, Chronic Active, Focal 1 (7%) 1 (7%)
Perivascular, Infiltration Cellular, Focal,
Lymphocyte 1 (7%)
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SPECIAL SENSES SYSTEM
None
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URINARY SYSTEM
Kidney (15) (15) (15) (15) (15) (15)
Infiltration Cellular, Focal, Lymphocyte 1 (7%) 2 (13%)
Pelvis, Infiltration Cellular, Focal,
Lymphocyte 1 (7%)
Renal Tubule, Degeneration, Focal 1 (7%)
Renal Tubule, Dilatation, Focal 4 (27%) 1 (7%) 1 (7%) 3 (20%)
Renal Tubule, Hyperplasia 1 (7%)
a Number of animals examined microscopically at site and number of animals with lesion
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