TDMS Study 88004-06 Pathology Tables
NTP Experiment-Test: 88004-06 INCIDENCE RATES OF NONNEOPLASTIC LESIONS BY ANATOMIC SITE (a) Report: PEIRPT18
Study Type: CHRONIC WITH AVERAGE SEVERITY GRADES[b] Date: 08/14/03
Route: RESPIRATORY EXPOSURE WHOLE BODY DIVINYLBENZENE Time: 13:13:26
FINAL #1 MICE
Facility: Battelle Northwest
Chemical CAS #: 1321-74-0
Lock Date: 06/17/02
Cage Range: All
Reasons For Removal: All
Removal Date Range: All
Treatment Groups: Include All
a Number of animals examined microscopically at site and number of animals with lesion
b Average severity grade (1-minimal;2-mild;3-moderate;4-marked)
Page 1
NTP Experiment-Test: 88004-06 INCIDENCE RATES OF NONNEOPLASTIC LESIONS BY ANATOMIC SITE (a) Report: PEIRPT18
Study Type: CHRONIC WITH AVERAGE SEVERITY GRADES[b] Date: 08/14/03
Route: RESPIRATORY EXPOSURE WHOLE BODY DIVINYLBENZENE Time: 13:13:26
____________________________________________________________________________________________________________________________________
B6C3F1 MICE FEMALE CONTROL 10 PPM 30 PPM 100 PPM
____________________________________________________________________________________________________________________________________
DISPOSITION SUMMARY
Animals Initially In Study 50 50 50 50
Early Deaths
Moribund Sacrifice 11 12 8 7
Natural Death 6 3 3 1
Accidently Killed 1
Survivors
Terminal Sacrifice 33 35 38 42
Animals Examined Microscopically 50 50 50 50
____________________________________________________________________________________________________________________________________
ALIMENTARY SYSTEM
Esophagus (50) (50) (50) (50)
Infiltration Cellular, Mixed Cell 1 [3.0]
Gallbladder (45) (41) (36) (41)
Hemorrhage, Chronic 1 [3.0]
Inflammation, Acute 1 [3.0]
Inflammation, Chronic 1 [2.0]
Intestine Large, Rectum (46) (48) (50) (50)
Artery, Inflammation, Chronic Active 1 [3.0]
Liver (49) (50) (50) (50)
Angiectasis 1 [1.0]
Basophilic Focus 4 2 2
Clear Cell Focus 4 2 3
Eosinophilic Focus 12 8 3 4
Fatty Change 2 [2.0] 1 [2.0]
Hematopoietic Cell Proliferation 1 [4.0] 1 [3.0] 1 [2.0]
Infarct 1
Inflammation, Acute 1 [3.0]
Inflammation, Chronic 1 [2.0]
Inflammation, Granulomatous 1 [3.0] 1 [1.0]
Mixed Cell Focus 1
Necrosis 1 [2.0] 3 [2.0] 1 [3.0]
Tension Lipidosis 1 [2.0] 5 [1.4] 2 [1.5] 4 [1.5]
Vacuolization Cytoplasmic, Focal 1 [3.0]
Centrilobular, Hypertrophy 1 [3.0]
Mesentery (17) (16) (4) (5)
Artery, Inflammation, Chronic Active 1 [2.0]
Fat, Congestion 1 [2.0]
Fat, Hemorrhage 1 [2.0]
Fat, Necrosis 17 [2.0] 15 [2.0] 3 [2.0] 5 [2.0]
a Number of animals examined microscopically at site and number of animals with lesion
b Average severity grade (1-minimal;2-mild;3-moderate;4-marked)
Page 2
NTP Experiment-Test: 88004-06 INCIDENCE RATES OF NONNEOPLASTIC LESIONS BY ANATOMIC SITE (a) Report: PEIRPT18
Study Type: CHRONIC WITH AVERAGE SEVERITY GRADES[b] Date: 08/14/03
Route: RESPIRATORY EXPOSURE WHOLE BODY DIVINYLBENZENE Time: 13:13:26
____________________________________________________________________________________________________________________________________
B6C3F1 MICE FEMALE CONTROL 10 PPM 30 PPM 100 PPM
____________________________________________________________________________________________________________________________________
ALIMENTARY SYSTEM - CONT
Pancreas (48) (50) (50) (50)
Atrophy 2 [4.0] 1 [4.0]
Basophilic Focus 1 [2.0]
Duct, Cyst 2 [4.0]
Stomach, Forestomach (50) (50) (50) (50)
Hyperplasia, Squamous 3 [1.7] 5 [2.2] 1 [2.0]
Inflammation, Chronic Active 1 [1.0] 2 [2.0]
Ulcer 1 [2.0] 1 [1.0]
Stomach, Glandular (49) (50) (49) (49)
Hemorrhage 1 [2.0]
Necrosis 1 [2.0]
Tooth (9) (13) (8) (15)
Incisor, Dysplasia 9 [1.7] 13 [1.7] 8 [1.5] 15 [1.7]
____________________________________________________________________________________________________________________________________
CARDIOVASCULAR SYSTEM
Blood Vessel (1)
Aorta, Mineralization 1 [2.0]
Heart (50) (50) (50) (50)
Cardiomyopathy 3 [1.0] 6 [1.0] 1 [1.0] 1 [1.0]
Infiltration Cellular, Polymorphonuclear 1 [2.0]
Inflammation, Suppurative 1 [2.0]
Mineralization 1 [1.0] 1 [2.0] 1 [1.0]
Necrosis 1 [2.0]
Thrombosis 1 [3.0]
Artery, Inflammation, Chronic Active 2 [2.0]
____________________________________________________________________________________________________________________________________
ENDOCRINE SYSTEM
Adrenal Cortex (50) (50) (50) (50)
Hematopoietic Cell Proliferation 1 [3.0]
Hyperplasia 1 [3.0] 2 [2.0] 5 [2.2] 4 [2.0]
Hypertrophy 3 [2.0] 2 [1.0] 8 [2.0]
Adrenal Medulla (49) (50) (49) (50)
Hyperplasia 1 [2.0] 1 [2.0] 2 [2.0]
Necrosis 1 [2.0]
Islets, Pancreatic (48) (49) (49) (50)
Hyperplasia 1 [3.0]
Pituitary Gland (47) (50) (49) (45)
Cyst 1 [2.0]
Pars Distalis, Angiectasis 3 [2.0]
a Number of animals examined microscopically at site and number of animals with lesion
b Average severity grade (1-minimal;2-mild;3-moderate;4-marked)
Page 3
NTP Experiment-Test: 88004-06 INCIDENCE RATES OF NONNEOPLASTIC LESIONS BY ANATOMIC SITE (a) Report: PEIRPT18
Study Type: CHRONIC WITH AVERAGE SEVERITY GRADES[b] Date: 08/14/03
Route: RESPIRATORY EXPOSURE WHOLE BODY DIVINYLBENZENE Time: 13:13:26
____________________________________________________________________________________________________________________________________
B6C3F1 MICE FEMALE CONTROL 10 PPM 30 PPM 100 PPM
____________________________________________________________________________________________________________________________________
ENDOCRINE SYSTEM - CONT
Pars Distalis, Hyperplasia 8 [2.4] 16 [2.1] 6 [1.7] 5 [2.2]
Thyroid Gland (49) (49) (50) (48)
C-Cell, Hyperplasia 1 [1.0]
Follicular Cell, Hyperplasia 1 [2.0] 2 [3.0] 1 [1.0]
____________________________________________________________________________________________________________________________________
GENERAL BODY SYSTEM
None
____________________________________________________________________________________________________________________________________
GENITAL SYSTEM
Ovary (48) (50) (49) (49)
Angiectasis 2 [2.5] 3 [2.7]
Cyst 9 [2.1] 14 [2.5] 10 [2.6] 9 [2.2]
Inflammation, Acute 1 [4.0]
Mineralization 1 [2.0]
Necrosis 1 [4.0]
Thrombosis 1 [3.0]
Uterus (49) (50) (50) (49)
Angiectasis 1 [3.0] 2 [3.0] 1 [4.0]
Endometrium, Hyperplasia, Cystic 2 [3.0] 8 [3.8] 5 [2.8] 8 [3.3]
____________________________________________________________________________________________________________________________________
HEMATOPOIETIC SYSTEM
Lymph Node (9) (3) (5) (2)
Ectasia 1 [3.0]
Deep Cervical, Hyperplasia, Lymphoid 1 [4.0]
Deep Cervical, Infiltration Cellular, Plasma
Cell 1 [3.0]
Iliac, Angiectasis 1 [3.0]
Iliac, Ectasia 1 [3.0]
Lumbar, Angiectasis 1 [3.0]
Renal, Angiectasis 1 [3.0]
Lymph Node, Mesenteric (49) (50) (49) (49)
Angiectasis 1 [3.0]
Ectasia 1 [3.0]
Inflammation, Granulomatous 1 [2.0]
Spleen (49) (50) (49) (49)
Hematopoietic Cell Proliferation 3 [2.7] 3 [3.0] 3 [2.7] 1 [3.0]
Inflammation, Acute 1 [3.0]
a Number of animals examined microscopically at site and number of animals with lesion
b Average severity grade (1-minimal;2-mild;3-moderate;4-marked)
Page 4
NTP Experiment-Test: 88004-06 INCIDENCE RATES OF NONNEOPLASTIC LESIONS BY ANATOMIC SITE (a) Report: PEIRPT18
Study Type: CHRONIC WITH AVERAGE SEVERITY GRADES[b] Date: 08/14/03
Route: RESPIRATORY EXPOSURE WHOLE BODY DIVINYLBENZENE Time: 13:13:26
____________________________________________________________________________________________________________________________________
B6C3F1 MICE FEMALE CONTROL 10 PPM 30 PPM 100 PPM
____________________________________________________________________________________________________________________________________
HEMATOPOIETIC SYSTEM - CONT
Necrosis 1 [3.0]
Sinusoid, Dilatation 1 [3.0]
____________________________________________________________________________________________________________________________________
INTEGUMENTARY SYSTEM
Skin (50) (50) (50) (50)
Inflammation, Chronic Active 3 [1.7] 2 [3.5] 1 [4.0]
____________________________________________________________________________________________________________________________________
MUSCULOSKELETAL SYSTEM
None
____________________________________________________________________________________________________________________________________
NERVOUS SYSTEM
Brain (50) (50) (50) (50)
Degeneration, Focal 1 [2.0]
Hemorrhage 1 [2.0]
Meninges, Infiltration Cellular, Mononuclear
Cell 1 [1.0] 1 [2.0]
____________________________________________________________________________________________________________________________________
RESPIRATORY SYSTEM
Larynx (48) (50) (50) (49)
Hyperplasia, Squamous 1 [2.0]
Inflammation, Suppurative 1 [2.0] 1 [1.0]
Lung (50) (50) (50) (49)
Hemorrhage 1 [1.0]
Infiltration Cellular, Polymorphonuclear 1 [2.0]
Inflammation, Acute 1 [2.0]
Thrombosis 1 [2.0]
Alveolar Epithelium, Hyperplasia 4 [1.8] 3 [1.7] 4 [2.3] 8 [2.5]
Alveolus, Granuloma 1 [1.0]
Alveolus, Infiltration Cellular, Histiocyte 3 [1.0] 6 [1.0] 9 [1.1] 17 [1.2]
Bronchiole, Hyperplasia 1 [4.0]
Bronchiole, Hyperplasia, Atypical 39 [1.3] 45 [1.8] 48 [2.1]
Nose (50) (50) (50) (49)
Inflammation, Suppurative 1 [1.0] 50 [1.7] 49 [2.0] 49 [2.4]
Glands, Respiratory Epithelium, Metaplasia 3 [1.0] 50 [3.1] 50 [3.6] 49 [4.0]
Olfactory Epithelium, Atrophy 8 [1.1]
a Number of animals examined microscopically at site and number of animals with lesion
b Average severity grade (1-minimal;2-mild;3-moderate;4-marked)
Page 5
NTP Experiment-Test: 88004-06 INCIDENCE RATES OF NONNEOPLASTIC LESIONS BY ANATOMIC SITE (a) Report: PEIRPT18
Study Type: CHRONIC WITH AVERAGE SEVERITY GRADES[b] Date: 08/14/03
Route: RESPIRATORY EXPOSURE WHOLE BODY DIVINYLBENZENE Time: 13:13:26
____________________________________________________________________________________________________________________________________
B6C3F1 MICE FEMALE CONTROL 10 PPM 30 PPM 100 PPM
____________________________________________________________________________________________________________________________________
RESPIRATORY SYSTEM - CONT
Olfactory Epithelium, Degeneration, Hyaline 2 [1.5] 50 [2.4] 40 [1.8] 8 [1.6]
Olfactory Epithelium, Respiratory Epithelium,
Metaplasia 50 [3.1] 50 [3.9] 49 [3.9]
Trachea (49) (50) (50) (50)
Inflammation, Suppurative 1 [2.0]
____________________________________________________________________________________________________________________________________
SPECIAL SENSES SYSTEM
Eye (50) (50) (50) (49)
Cataract 1 [3.0] 2 [2.5] 1 [2.0]
Inflammation 1 [2.0]
Phthisis Bulbi 1 [4.0] 1 [3.0]
Cornea, Hyperplasia, Squamous 1 [2.0]
Cornea, Inflammation, Chronic Active 1 [2.0] 3 [2.3] 3 [3.0]
Cornea, Inflammation, Suppurative 1 [3.0]
Cornea, Mineralization 6 [1.0]
Harderian Gland (50) (50) (50) (50)
Hyperplasia 1 [3.0] 4 [2.5] 2 [2.0] 3 [2.3]
Inflammation, Chronic Active 1 [4.0]
____________________________________________________________________________________________________________________________________
URINARY SYSTEM
Kidney (49) (50) (50) (50)
Amyloid Deposition 1 [3.0]
Infarct 1 [4.0]
Inflammation, Suppurative 2 [2.5] 2 [3.5]
Metaplasia, Osseous 2 [1.5] 3 [1.3] 3 [1.0] 1 [1.0]
Mineralization 1 [1.0]
Nephropathy 25 [1.3] 31 [1.3] 22 [1.2] 17 [1.1]
Artery, Inflammation, Chronic Active 1 [2.0]
Urinary Bladder (49) (50) (50) (49)
Inflammation, Suppurative 1 [2.0]
Artery, Inflammation, Chronic Active 1 [2.0]
a Number of animals examined microscopically at site and number of animals with lesion
b Average severity grade (1-minimal;2-mild;3-moderate;4-marked)
Page 6
NTP Experiment-Test: 88004-06 INCIDENCE RATES OF NONNEOPLASTIC LESIONS BY ANATOMIC SITE (a) Report: PEIRPT18
Study Type: CHRONIC WITH AVERAGE SEVERITY GRADES[b] Date: 08/14/03
Route: RESPIRATORY EXPOSURE WHOLE BODY DIVINYLBENZENE Time: 13:13:26
____________________________________________________________________________________________________________________________________
B6C3F1 MICE MALE CONTROL 10 PPM 30 PPM 100 PPM
____________________________________________________________________________________________________________________________________
DISPOSITION SUMMARY
Animals Initially In Study 50 50 50 50
Early Deaths
Moribund Sacrifice 7 6 5 4
Natural Death 2 6 3 3
Survivors
Terminal Sacrifice 41 38 42 43
Animals Examined Microscopically 50 50 50 50
____________________________________________________________________________________________________________________________________
ALIMENTARY SYSTEM
Liver (50) (50) (50) (50)
Angiectasis 1 [1.0]
Basophilic Focus 3 6 7 4
Clear Cell Focus 9 11 6 5
Eosinophilic Focus 8 7 2
Fatty Change 2 [1.5] 1 [2.0]
Infarct 2 1
Inflammation, Granulomatous 1 [1.0]
Mineralization 1 [1.0]
Mixed Cell Focus 2 1 2 1
Necrosis 1 [1.0] 2 [1.5] 2 [3.0] 2 [3.0]
Tension Lipidosis 2 [2.0] 1 [2.0] 2 [1.5] 1 [2.0]
Vacuolization Cytoplasmic, Focal 2 [2.5]
Mesentery (11) (4) (4) (5)
Fat, Necrosis 10 [2.0] 4 [2.0] 4 [2.0] 5 [2.0]
Pancreas (49) (48) (50) (50)
Duct, Cyst 2 [3.5]
Stomach, Forestomach (49) (50) (49) (50)
Hyperplasia, Squamous 1 [2.0] 4 [2.5] 2 [1.0] 4 [2.3]
Inflammation 1 [2.0]
Inflammation, Acute 2 [1.5] 1 [1.0]
Inflammation, Chronic Active 1 [2.0] 1 [2.0] 3 [2.3]
Mineralization 1 [1.0]
Ulcer 2 [2.5] 1 [2.0] 1 [3.0]
Stomach, Glandular (48) (48) (47) (49)
Inflammation, Acute 1 [1.0]
Mineralization 1 [2.0]
Necrosis 1 [2.0] 1 [1.0]
Tooth (41) (43) (41) (35)
Incisor, Dysplasia 41 [2.2] 43 [2.6] 41 [2.5] 35 [2.3]
a Number of animals examined microscopically at site and number of animals with lesion
b Average severity grade (1-minimal;2-mild;3-moderate;4-marked)
Page 7
NTP Experiment-Test: 88004-06 INCIDENCE RATES OF NONNEOPLASTIC LESIONS BY ANATOMIC SITE (a) Report: PEIRPT18
Study Type: CHRONIC WITH AVERAGE SEVERITY GRADES[b] Date: 08/14/03
Route: RESPIRATORY EXPOSURE WHOLE BODY DIVINYLBENZENE Time: 13:13:26
____________________________________________________________________________________________________________________________________
B6C3F1 MICE MALE CONTROL 10 PPM 30 PPM 100 PPM
____________________________________________________________________________________________________________________________________
CARDIOVASCULAR SYSTEM
Heart (50) (49) (50) (50)
Cardiomyopathy 14 [1.1] 5 [1.0] 5 [1.0] 5 [1.0]
Mineralization 1 [1.0] 1 [1.0] 1 [1.0]
Artery, Inflammation, Chronic Active 1 [3.0]
____________________________________________________________________________________________________________________________________
ENDOCRINE SYSTEM
Adrenal Cortex (49) (49) (50) (50)
Hyperplasia 9 [2.0] 10 [1.9] 6 [1.7] 5 [2.0]
Hypertrophy 24 [2.0] 25 [1.9] 26 [2.0] 24 [1.6]
Adrenal Medulla (49) (49) (50) (50)
Hyperplasia 1 [2.0] 2 [2.0] 2 [2.5]
Parathyroid Gland (35) (39) (36) (35)
Hyperplasia 1 [3.0]
Pituitary Gland (48) (47) (47) (46)
Cyst 1 [3.0]
Pars Distalis, Hyperplasia 2 [2.5] 1 [2.0] 2 [1.5] 1 [1.0]
Thyroid Gland (49) (49) (50) (50)
Follicular Cell, Hyperplasia 2 [1.5] 1 [3.0]
____________________________________________________________________________________________________________________________________
GENERAL BODY SYSTEM
None
____________________________________________________________________________________________________________________________________
GENITAL SYSTEM
Epididymis (50) (50) (50) (50)
Granuloma Sperm 1 [2.0] 2 [1.5]
Penis (1)
Inflammation, Acute 1 [4.0]
Preputial Gland (50) (50) (50) (50)
Ectasia 1 [2.0] 3 [2.3] 2 [3.0] 1 [3.0]
Inflammation, Chronic Active 2 [3.0]
Seminal Vesicle (49) (48) (50) (49)
Inflammation, Chronic 1 [3.0]
Testes (50) (50) (50) (50)
Atrophy 2 [3.0]
Mineralization 1 [4.0]
a Number of animals examined microscopically at site and number of animals with lesion
b Average severity grade (1-minimal;2-mild;3-moderate;4-marked)
Page 8
NTP Experiment-Test: 88004-06 INCIDENCE RATES OF NONNEOPLASTIC LESIONS BY ANATOMIC SITE (a) Report: PEIRPT18
Study Type: CHRONIC WITH AVERAGE SEVERITY GRADES[b] Date: 08/14/03
Route: RESPIRATORY EXPOSURE WHOLE BODY DIVINYLBENZENE Time: 13:13:26
____________________________________________________________________________________________________________________________________
B6C3F1 MICE MALE CONTROL 10 PPM 30 PPM 100 PPM
____________________________________________________________________________________________________________________________________
GENITAL SYSTEM - CONT
Interstitial Cell, Hyperplasia 1 [2.0]
____________________________________________________________________________________________________________________________________
HEMATOPOIETIC SYSTEM
Bone Marrow (50) (48) (50) (50)
Necrosis 1 [4.0]
Spleen (49) (48) (50) (50)
Hematopoietic Cell Proliferation 1 [3.0] 1 [2.0]
____________________________________________________________________________________________________________________________________
INTEGUMENTARY SYSTEM
Skin (50) (50) (50) (50)
Cyst Epithelial Inclusion 1 [3.0]
Inflammation, Chronic Active 3 [2.0] 1 [1.0] 2 [3.5]
Inflammation, Granulomatous 1 [2.0]
Subcutaneous Tissue, Cyst Epithelial
Inclusion 1
____________________________________________________________________________________________________________________________________
MUSCULOSKELETAL SYSTEM
None
____________________________________________________________________________________________________________________________________
NERVOUS SYSTEM
Brain (50) (50) (50) (50)
Necrosis, Focal 1 [2.0]
Artery, Inflammation, Chronic Active 1 [2.0]
____________________________________________________________________________________________________________________________________
RESPIRATORY SYSTEM
Larynx (50) (50) (50) (50)
Inflammation, Suppurative 1 [3.0]
Lung (49) (49) (49) (49)
Hemorrhage 1 [2.0] 1 [4.0]
Mineralization 1 [2.0]
Alveolar Epithelium, Hyperplasia 1 [1.0] 5 [3.2] 5 [2.0] 7 [2.0]
Alveolus, Infiltration Cellular, Histiocyte 2 [1.5] 4 [1.0] 5 [1.0] 1 [1.0]
Bronchiole, Hyperplasia 1 [1.0]
a Number of animals examined microscopically at site and number of animals with lesion
b Average severity grade (1-minimal;2-mild;3-moderate;4-marked)
Page 9
NTP Experiment-Test: 88004-06 INCIDENCE RATES OF NONNEOPLASTIC LESIONS BY ANATOMIC SITE (a) Report: PEIRPT18
Study Type: CHRONIC WITH AVERAGE SEVERITY GRADES[b] Date: 08/14/03
Route: RESPIRATORY EXPOSURE WHOLE BODY DIVINYLBENZENE Time: 13:13:26
____________________________________________________________________________________________________________________________________
B6C3F1 MICE MALE CONTROL 10 PPM 30 PPM 100 PPM
____________________________________________________________________________________________________________________________________
RESPIRATORY SYSTEM - CONT
Bronchiole, Hyperplasia, Atypical 38 [1.1] 46 [1.8] 46 [1.9]
Bronchiole, Inflammation, Chronic Active 1 [3.0]
Nose (50) (50) (49) (50)
Inflammation, Suppurative 3 [1.0] 47 [1.4] 49 [1.9] 49 [1.9]
Glands, Necrosis 1 [2.0]
Glands, Respiratory Epithelium, Metaplasia 12 [1.0] 50 [2.9] 49 [4.0] 50 [3.9]
Olfactory Epithelium, Atrophy 14 [1.1]
Olfactory Epithelium, Degeneration, Hyaline 5 [1.0] 50 [1.9] 48 [1.8] 11 [1.1]
Olfactory Epithelium, Respiratory Epithelium,
Metaplasia 1 [2.0] 50 [3.1] 49 [4.0] 50 [3.9]
Respiratory Epithelium, Metaplasia, Squamous 1 [2.0]
Sinus, Foreign Body 1
____________________________________________________________________________________________________________________________________
SPECIAL SENSES SYSTEM
Eye (49) (47) (47) (50)
Phthisis Bulbi 1 [4.0] 1 [3.0]
Cornea, Inflammation, Chronic Active 2 [2.0] 1 [3.0] 1 [2.0]
Cornea, Mineralization 2 [1.0]
Harderian Gland (50) (49) (50) (50)
Hyperplasia 2 [2.0] 2 [2.0] 3 [2.7] 2 [1.5]
____________________________________________________________________________________________________________________________________
URINARY SYSTEM
Kidney (50) (50) (50) (50)
Cyst 1 [2.0] 2 [2.0]
Infarct 1 [3.0] 2 [2.5] 1 [2.0]
Inflammation, Suppurative 1 [2.0]
Metaplasia, Osseous 7 [1.0] 3 [1.0] 5 [1.0] 1 [1.0]
Nephropathy 45 [1.6] 43 [1.5] 40 [1.3] 34 [1.3]
Capsule, Fibrosis 1 [1.0]
Papilla, Necrosis 1 [2.0]
Pelvis, Dilatation 1 [2.0]
Renal Tubule, Hyperplasia 2 [1.0] 1 [1.0]
Renal Tubule, Necrosis 1 [2.0]
Urinary Bladder (48) (48) (49) (49)
Transitional Epithelium, Hyperplasia 1 [3.0]
a Number of animals examined microscopically at site and number of animals with lesion
b Average severity grade (1-minimal;2-mild;3-moderate;4-marked)
Page 10
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