https://ntp.niehs.nih.gov/go/20584

TDMS Study 93020-07 Pathology Tables

NTP  EXP/TEST: 93020-07                             DIISOPROPYLCARBODIIMIDE                                       PAGE: 1
TEST TYPE: CHRONIC               DERMAL CLINICAL OBSERVATIONS AT SITE OF APPLICATION BY ANIMAL                    DATE: 06/30/04
ROUTE: SKIN APPLICATION                                                                                           TIME: 11:15:09
                                                         EIS REPORT 37
       FACILITY:  Southern Research Institute
       NTP C#:  93020D
       CONTRACT NUMBER:  N01-ES 05451
       CAS NUMBER:  693-13-0
       ANIMAL SUPPLIER:  TACONIC FARMS
       CAGE RANGE:  ALL
       DATE RANGE: ALL
       REASONS FOR REMOVAL:    ALL
       REMOVAL DATE RANGE:     ALL
       TREATMENT GROUPS:       INCLUDE ALL
NTP  EXP/TEST: 93020-07                             DIISOPROPYLCARBODIIMIDE                                       PAGE: 2
TEST TYPE: CHRONIC               DERMAL CLINICAL OBSERVATIONS AT SITE OF APPLICATION BY ANIMAL                    DATE: 06/30/04
ROUTE: SKIN APPLICATION                                     EISRPT37                                              TIME: 11:15:09
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 SPECIES-STRAIN: RATS-F 344                          TRT#: 2                      ROOM/AREA:     21         FIRST DOSE: 04/24/00
            SEX: FEMALE                               TRT: 0 MG/KG            PROCEDURE SET:      2
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                FIRST OCCUR'D  LAST  OCCUR'D  FREQ/
CAGE     ANIMAL  DAY    DATE    DAY    DATE  TOT OBS      CLINICAL OBSERVATION
----     ------ -------------  ------------- ------- ------------------------------
                              THERE WERE NO DERMAL OBSERVATIONS FOR THIS SPECIES, STRAIN, SEX, AND TREATMENT GROUP.
NTP  EXP/TEST: 93020-07                             DIISOPROPYLCARBODIIMIDE                                       PAGE: 3
TEST TYPE: CHRONIC               DERMAL CLINICAL OBSERVATIONS AT SITE OF APPLICATION BY ANIMAL                    DATE: 06/30/04
ROUTE: SKIN APPLICATION                                     EISRPT37                                              TIME: 11:15:09
------------------------------------------------------------------------------------------------------------------------------------
 SPECIES-STRAIN: RATS-F 344                          TRT#: 4                      ROOM/AREA:     21         FIRST DOSE: 04/24/00
            SEX: FEMALE                               TRT: 10 MG/KG           PROCEDURE SET:      2
------------------------------------------------------------------------------------------------------------------------------------
                FIRST OCCUR'D  LAST  OCCUR'D  FREQ/
CAGE     ANIMAL  DAY    DATE    DAY    DATE  TOT OBS      CLINICAL OBSERVATION
----     ------ -------------  ------------- ------- ------------------------------
                              THERE WERE NO DERMAL OBSERVATIONS FOR THIS SPECIES, STRAIN, SEX, AND TREATMENT GROUP.
NTP  EXP/TEST: 93020-07                             DIISOPROPYLCARBODIIMIDE                                       PAGE: 4
TEST TYPE: CHRONIC               DERMAL CLINICAL OBSERVATIONS AT SITE OF APPLICATION BY ANIMAL                    DATE: 06/30/04
ROUTE: SKIN APPLICATION                                     EISRPT37                                              TIME: 11:15:09
------------------------------------------------------------------------------------------------------------------------------------
 SPECIES-STRAIN: RATS-F 344                          TRT#: 6                      ROOM/AREA:     21         FIRST DOSE: 04/24/00
            SEX: FEMALE                               TRT: 20 MG/KG           PROCEDURE SET:      2
------------------------------------------------------------------------------------------------------------------------------------
                FIRST OCCUR'D  LAST  OCCUR'D  FREQ/
CAGE     ANIMAL  DAY    DATE    DAY    DATE  TOT OBS      CLINICAL OBSERVATION
----     ------ -------------  ------------- ------- ------------------------------
                              THERE WERE NO DERMAL OBSERVATIONS FOR THIS SPECIES, STRAIN, SEX, AND TREATMENT GROUP.
NTP  EXP/TEST: 93020-07                             DIISOPROPYLCARBODIIMIDE                                       PAGE: 5
TEST TYPE: CHRONIC               DERMAL CLINICAL OBSERVATIONS AT SITE OF APPLICATION BY ANIMAL                    DATE: 06/30/04
ROUTE: SKIN APPLICATION                                     EISRPT37                                              TIME: 11:15:09
------------------------------------------------------------------------------------------------------------------------------------
 SPECIES-STRAIN: RATS-F 344                          TRT#: 8                      ROOM/AREA:     21         FIRST DOSE: 04/24/00
            SEX: FEMALE                               TRT: 40 MG/KG           PROCEDURE SET:      2
------------------------------------------------------------------------------------------------------------------------------------
                FIRST OCCUR'D  LAST  OCCUR'D  FREQ/
CAGE     ANIMAL  DAY    DATE    DAY    DATE  TOT OBS      CLINICAL OBSERVATION
----     ------ -------------  ------------- ------- ------------------------------
                              THERE WERE NO DERMAL OBSERVATIONS FOR THIS SPECIES, STRAIN, SEX, AND TREATMENT GROUP.
NTP  EXP/TEST: 93020-07                             DIISOPROPYLCARBODIIMIDE                                       PAGE: 6
TEST TYPE: CHRONIC               DERMAL CLINICAL OBSERVATIONS AT SITE OF APPLICATION BY ANIMAL                    DATE: 06/30/04
ROUTE: SKIN APPLICATION                                     EISRPT37                                              TIME: 11:15:09
------------------------------------------------------------------------------------------------------------------------------------
 SPECIES-STRAIN: RATS-F 344                          TRT#: 1                      ROOM/AREA:     21         FIRST DOSE: 04/24/00
            SEX: MALE                                 TRT: 0 MG/KG            PROCEDURE SET:      1
------------------------------------------------------------------------------------------------------------------------------------
                FIRST OCCUR'D  LAST  OCCUR'D  FREQ/
CAGE     ANIMAL  DAY    DATE    DAY    DATE  TOT OBS      CLINICAL OBSERVATION
----     ------ -------------  ------------- ------- ------------------------------
                              THERE WERE NO DERMAL OBSERVATIONS FOR THIS SPECIES, STRAIN, SEX, AND TREATMENT GROUP.
NTP  EXP/TEST: 93020-07                             DIISOPROPYLCARBODIIMIDE                                       PAGE: 7
TEST TYPE: CHRONIC               DERMAL CLINICAL OBSERVATIONS AT SITE OF APPLICATION BY ANIMAL                    DATE: 06/30/04
ROUTE: SKIN APPLICATION                                     EISRPT37                                              TIME: 11:15:09
------------------------------------------------------------------------------------------------------------------------------------
 SPECIES-STRAIN: RATS-F 344                          TRT#: 3                      ROOM/AREA:     21         FIRST DOSE: 04/24/00
            SEX: MALE                                 TRT: 10 MG/KG           PROCEDURE SET:      1
------------------------------------------------------------------------------------------------------------------------------------
                FIRST OCCUR'D  LAST  OCCUR'D  FREQ/
CAGE     ANIMAL  DAY    DATE    DAY    DATE  TOT OBS      CLINICAL OBSERVATION
----     ------ -------------  ------------- ------- ------------------------------
                              THERE WERE NO DERMAL OBSERVATIONS FOR THIS SPECIES, STRAIN, SEX, AND TREATMENT GROUP.
NTP  EXP/TEST: 93020-07                             DIISOPROPYLCARBODIIMIDE                                       PAGE: 8
TEST TYPE: CHRONIC               DERMAL CLINICAL OBSERVATIONS AT SITE OF APPLICATION BY ANIMAL                    DATE: 06/30/04
ROUTE: SKIN APPLICATION                                     EISRPT37                                              TIME: 11:15:09
------------------------------------------------------------------------------------------------------------------------------------
 SPECIES-STRAIN: RATS-F 344                          TRT#: 5                      ROOM/AREA:     21         FIRST DOSE: 04/24/00
            SEX: MALE                                 TRT: 20 MG/KG           PROCEDURE SET:      1
------------------------------------------------------------------------------------------------------------------------------------
                FIRST OCCUR'D  LAST  OCCUR'D  FREQ/
CAGE     ANIMAL  DAY    DATE    DAY    DATE  TOT OBS      CLINICAL OBSERVATION
----     ------ -------------  ------------- ------- ------------------------------
143         143  617 12/31/01   645 01/28/02   2/22  Ulcer Site Of Application
  REMOVED  **  CID   143 **   REASON - MSAC
                                649 02/01/02         Ulcer/Abscess Appendage 2
                                649 02/01/02         Lethargic
                                649 02/01/02         Nasal/Eye Discharge
                                649 02/01/02         Ulcer Site Of Application
NTP  EXP/TEST: 93020-07                             DIISOPROPYLCARBODIIMIDE                                       PAGE: 9
TEST TYPE: CHRONIC               DERMAL CLINICAL OBSERVATIONS AT SITE OF APPLICATION BY ANIMAL                    DATE: 06/30/04
ROUTE: SKIN APPLICATION                                     EISRPT37                                              TIME: 11:15:09
------------------------------------------------------------------------------------------------------------------------------------
 SPECIES-STRAIN: RATS-F 344                          TRT#: 7                      ROOM/AREA:     21         FIRST DOSE: 04/24/00
            SEX: MALE                                 TRT: 40 MG/KG           PROCEDURE SET:      1
------------------------------------------------------------------------------------------------------------------------------------
                FIRST OCCUR'D  LAST  OCCUR'D  FREQ/
CAGE     ANIMAL  DAY    DATE    DAY    DATE  TOT OBS      CLINICAL OBSERVATION
----     ------ -------------  ------------- ------- ------------------------------
                              THERE WERE NO DERMAL OBSERVATIONS FOR THIS SPECIES, STRAIN, SEX, AND TREATMENT GROUP.
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